Chronic Fatigue Syndrome malady

MedlinePlus: Chronic fatigue syndrome (cfs) is a disorder that causes extreme fatigue. this fatigue is not the kind of tired feeling that goes away after you rest. instead, it lasts a long time and limits your ability to do ordinary daily activities. symptoms of cfs include fatigue for 6 months or more and experiencing other problems such as muscle pain, memory problems, headaches, pain in multiple joints, sleep problems, sore throat and tender lymph nodes. since other illnesses can cause similar symptoms, cfs is hard to diagnose. no one knows what causes cfs. it is most common in women in their 40s and 50s, but anyone can have it. it can last for years. there is no cure for cfs, so the goal of treatment is to improve symptoms. medicines may treat pain, sleep disorders and other problems. centers for disease control and prevention²³

MalaCards: Chronic Fatigue Syndrome, also known as postviral fatigue syndrome (disorder), is related to encephalitis and allergic rhinitis. An important gene associated with Chronic Fatigue Syndrome is RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Graft-versus-host disease. The drugs fish oil and coenzyme q10 and the compounds bromocriptine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are respiratory system and hematopoietic system.

Disease Ontology: A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to extertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.⁶

Genetics Home Reference: Cystic fibrosis is an inherited disease characterized by the buildup of thick, sticky mucus that can damage many of the body's organs. The disorder's most common signs and symptoms include progressive damage to the respiratory system and chronic digestive system problems. The features of the disorder and their severity varies among affected individuals.¹⁷

CDC: Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms affect several body systems and may include weakness, muscle pain, impaired memory and/or mental concentration, and insomnia, which can result in reduced participation in daily activities.²

Wikipedia: Chronic fatigue syndrome (CFS) is the most common name used to designate a significantly...⁴⁴ more...

Aliases & Descriptions:

chronic fatigue syndrome 6 8 32 23 43 postviral fatigue syndrome (disorder) 6 myalgic encephalomyelitis 6 myalgic encephalitis 6

encephalitis 43 cfs 6

Diseases related to chronic fatigue syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 930)

id	Related Disease	Score	Top Affiliating Genes
1	encephalitis	32.4	B2M, CD4, GSR, IL10, IL2RB, IL4
2	allergic rhinitis	29.9	VIP, IL4, IGHE, NR3C1, RNASE3
3	seasonal affective disorder	29.6	HTR1A, HTR2A, HTR2C, CRH, PRL, POMC
4	sleeping sickness	28.5	GSR, IL10, IL6, IFNG, NOS2
5	hepatitis	28.3	GSR, IL2RB, HLA-DRB1, LTF, TF, SLC17A5
6	rheumatoid arthritis	28.0	IL1R1, IL1R2, HLA-DRB1, LTA
7	immunodeficiency	27.8	VIP, CD69, CD4, INS, IL10, IL17F
8	herpes simplex	27.7	LMNB1, LBR, CD4, IL10, IL1R1, IL2
9	meningoencephalitis	27.6	B2M, CD4, IL6, TNF, SLC17A5
10	fibromyalgia	27.3	INS, IL10, IL2, IL4, IL6, MAOA
11	acquired immunodeficiency syndrome	27.1	LBR, B2M, CD69, CD4, GSR, IL1R1
12	acute disseminated encephalomyelitis	27.1	IL10, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, POMC
13	parkinson's disease	26.9	GSR, MAOA, HTR1A, HTR2A, HTR2C, HTR3A
14	panhypopituitarism	26.9	IGFBP1, IGF2, IGF1, GH1, ELANE, PRL
15	allergic bronchopulmonary aspergillosis	26.7	IL10, IL4, IGHE, IFNG, HLA-DRB1
16	hypersomnia	26.6	INS, GH1, HLA-DQB1, HLA-DRB1
17	cerebral malaria	26.6	IL10, IL1R1, IFNG, TNF, NOS2
18	rabies	26.5	VIP, IL10, IL4, IGHE, IFNG, HTR1A
19	bacterial meningitis	26.5	IL10, IGHE, TNF, TLR4, SLC17A5
20	subacute sclerosing panencephalitis	26.4	IL10, IL1R1, IL2, IL4, IL6, IFNG
21	temporal lobe epilepsy	26.4	GRIK2, IL6, MAOA, HTR1A, HTR2C, CRH
22	diabetes insipidus	26.3	INS, IGF1, CRH, PRL, POMC
23	alcoholism	26.3	LBR, GSR, MAOA, HTR1A, HTR2A, HTR2C
24	paine syndrome	26.1	IL10, IL2, IL6, IFNG, HLA-DQB1, HLA-DRB1
25	was-related disorders	25.8	B2M, INS, IL6, IGF1, HTR2A, GH1
26	thymoma	25.8	VIP, LBR, B2M, CD69, CD4, IL1R1
27	lymphocytic choriomeningitis	25.6	CD4, IL2, IFNG, TNF
28	hepatic encephalopathy	25.6	IL6, MAOA, TNF, DRD2, SLC17A5
29	medulloblastoma	25.2	VIP, INS, GSR, IL17F, IL6R, IL6ST
30	malaria	25.1	IL10, IL4, IFNG, TNF, NOS2
31	hypoglycemia	25.0	SERPINA6, P2RX4, INS, IL6, IGFBP1, IGF2
32	lyme disease	24.9	IL6, IFNG, HLA-DQB1, HLA-DRB1, TNF
33	neurologic diseases	24.7	B2M, IL2, IL6, IFNG, TNF, CRH
34	febrile seizures	24.4	IL10, IL1R1, IL4, IL6, TNF, TLR4
35	trypanosomiasis	24.3	GSR, IL10, IL2, IL4, IL6, IFNG
36	rhinitis	24.1	VIP, CD4, IL10, IL1R1, IL4, IL6
37	hepatitis a	23.6	B2M, CD4, IL10, IL2, IGHE, IFNG
38	encephalomyelitis	23.6	PDCD2, VIP, IL10, IL1R1, IL2, IL2RB
39	meningitis	23.5	VIP, B2M, CD4, GSR, IL10, IL1R1
40	aspergillosis	23.4	CD4, IL10, IL1R1, IL4, IL6, IGHE
41	measles	23.2	LBR, CD4, IL10, IL2, IL2RB, IL4
42	hepatitis c	22.9	CD69, GSR, IL10, IL2, IL4, IL6R
43	cholera	22.9	VIP, CD4, INS, IL10, IL2, IL4
44	seizures	22.8	VIP, LBR, INS, GRIK2, IL10, IL1R1
45	anorexia nervosa	22.5	LBR, INS, GSR, IL6, MAOA, IGFBP1
46	neurodegeneration	22.0	VIP, CD4, INS, GSR, IL10, APLP1
47	infertility	21.4	SERPINA6, CD69, INS, GSR, IL10, IL1R2
48	colon carcinoma	21.1	VIP, B2M, CD4, INS, GSR, IL10
49	astrocytoma	20.8	SERPINA6, CHRM1, CD4, IL10, IL2, IL4
50	cystic fibrosis	20.2	VIP, LBR, CD4, INS, GSR, IL10

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 coenzyme q10, fish oil, venlafaxine, venlafaxine hydrochloride

MalaCards organs/tissues related to chronic fatigue syndrome:

²²

MGI Mouse Phenotypes related to chronic fatigue syndrome:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	CRH, DRD2, TPH2, IL17F, CHRM1
2	hematopoietic system phenotype	MP:0005397	10.0	HLA-DQB1, HLA-DQA1, IGHE, IGF2, CD69, P2RX5
3	endocrine/exocrine gland phenotype	MP:0005379	9.7	DPP4, TKT, LTA, HTR2A, IFNG, IL2RB
4	renal/urinary system phenotype	MP:0005367	8.9	TKT, NOS3, DRD2, HTR3A, INS, P2RX4
5	integument phenotype	MP:0010771	8.5	TPH2, DRD2, NR3C1, CRH, TLR4, PRL
6	no phenotypic analysis	MP:0003012	8.0	ADRB1, ADRB2, POMC, AGER, PTGS2, DRD2
7	skeleton phenotype	MP:0005390	7.9	HTR2B, DRD2, PTGS2, NR3C1, ADRB1, IGF1
8	digestive/alimentary phenotype	MP:0005381	7.8	NPY, NOS3, NOS2, NR3C1, DRD2, HTR2A
9	liver/biliary system phenotype	MP:0005370	7.4	ADCYAP1, PRL, TLR4, NOS3, DRD2, GH1
10	nervous system phenotype	MP:0003631	7.1	TLR4, GRIK2, INS, CD4, P2RX4, LBR
11	immune system phenotype	MP:0005387	6.8	MASP2, IL6R, IL6, IL2, CD4, P2RX5
12	mortality/aging	MP:0010768	6.7	EIF2AK2, LTA, NOS3, NOS2, NR3C1, SUN2
13	growth/size phenotype	MP:0005378	6.7	TKT, TLR4, AGER, LTA, NOS3, CRH
14	normal phenotype	MP:0002873	6.6	HLA-DQB1, TNFRSF17, PTGS2, SUN2, NR3C1, CRH
15	reproductive system phenotype	MP:0005389	6.3	DRD2, PTGS2, SUN2, NOS2, COMT, TLR4
16	tumorigenesis	MP:0002006	6.0	PTGS2, NOS2, EIF2AK2, ELANE, TLR4, PRL
17	adipose tissue phenotype	MP:0005375	6.0	ADCYAP1, HTR2C, IGF1, IGFBP3, IL6R, IL6
18	muscle phenotype	MP:0005369	5.7	DRD2, PTGS2, SUN2, NOS2, NOS3, AGER
19	vision/eye phenotype	MP:0005391	5.5	TNF, PTGS2, NOS2, NOS3, LTA, TLR4
20	cardiovascular system phenotype	MP:0005385	4.5	LTA, COMT, NOS3, NOS2, NR3C1, PTGS2
21	homeostasis/metabolism phenotype	MP:0005376	4.4	NPAS2, POMC, SOCS7, PRL, TF, DPP4
22	cellular phenotype	MP:0005384	4.1	NOS2, CRH, NR3C1, PTGS2, DRD2, TNF
23	behavior/neurological phenotype	MP:0005386	3.2	ADCYAP1, ADRB2, SLC6A4, SLC17A5, NPY, NPAS2

Articles related to chronic fatigue syndrome:

(show top 50)    (show all 101)

id	Title	Authors	Year	Affiliating Genes
1	Convergent genomic studies identify association of GR IK2 and NPAS2 with chronic fatigue syndrome. (21912186)	Smith A.K.... Rajeevan M.S.	2011	GRIK2, NPAS2
2	Polymorphisms of adrenergic cardiovascular control ge nes are associated with adolescent chronic fatigue syndrome. (21059181)	Sommerfeldt L.... Wyller V.B.	2010	COMT, ADRB2, ADRB1
3	Plasma neuropeptide Y: a biomarker for symptom severi ty in chronic fatigue syndrome. (21190576)	Fletcher M.A.... Klimas N.G.	2010	NPY
4	Raltegravir is a potent inhibitor of XMRV, a virus im plicated in prostate cancer and chronic fatigue syndrome. (20376347)	Singh I.R.... Schinazi R.F.	2010	ERVK-6
5	A functional polymorphism in the disrupted-in schizop hrenia 1 gene is associated with chronic fatigue syndrome. (20227423)	Fukuda S.... Watanabe Y.	2010	DISC1
6	Glucocorticoid receptor mediated negative feedback in chronic fatigue syndrome using the low dose (0.5 mg) dexamethasone suppression test. (18573538)	Papadopoulos A.... Cleare A.J.	2009	NR3C1
7	Molecular study of receptor for advanced glycation en dproduct gene promoter and identification of specific HLA haplotypes possibly i nvolved in chronic fatigue syndrome. (19822091)	Carlo-Stella N.... Cuccia M.	2009	AGER, HLA-DRB1
8	Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue? (20032425)	Meeus M.... Nijs J.	2009	RNASEL
9	Coenzyme Q10 deficiency in myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocog nitive symptoms and is another risk factor explaining the early mortality in ME /CFS due to cardiovascular disorder. (20010505)	Maes M.... Bosmans E.	2009	PDSS1
10	Autoantibodies, polymorphisms in the serotonin pathwa y, and human leukocyte antigen class II alleles in chronic fatigue syndrome: ar e they associated with age at onset and specific symptoms? (19758204)	Ortega-Hernandez O.D.... Shoenfeld Y.	2009	HTR2A, HLA-DRB1
11	Chronic fatigue syndrome combines increased exercise- induced oxidative stress and reduced cytokine and Hsp responses. (19457057)	Jammes Y.... BrAcgeon F.	2009	HSPB1
12	Identification of marker genes for differential diagn osis of chronic fatigue syndrome. (18596870)	Saiki T.... Ban N.	2008	ATP5J2
13	Combined dexamethasone/corticotropin-releasing factor test in chronic fatigue syndrome. (17803834)	Van Den Eede F.... Claes S.J.	2008	CRH
14	Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance. (18396793)	Meeus M.... De Meirleir K.	2008	RNASEL
15	Genetic evaluation of the serotonergic system in chronic fatigue syndrome. (18079067)	Smith A.K.... Rajeevan M.S.	2008	HTR2C, MAOA, HTR7
16	Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome. (16740143)	Rajeevan M.S.... Reeves W.C.	2007	NR3C1
17	Overlap between atypical depression, seasonal affective disorder and chronic fatigue syndrome (17546343)	Juruena M.F.... Cleare A.J.	2007	POMC
18	Variability of the RNase L isoform ratio (37 kiloDaltons/83 kiloDaltons) in diagnosis of chronic fatigue syndrome. (15699437)	Tiev K.P.... Lebleu B.	2005	RNASEL
19	Chronic ACTH autoantibodies are a significant pathological factor in the disruption of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome, anorexia nervosa and major depression. (15885924)	Wheatland R.	2005	POMC
20	Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation? (15617866)	Nijs J.... De Meirleir K.	2005	RNASEL
21	Association of chronic fatigue syndrome with human leucocyte antigen class II alleles. (16049290)	Smith J.... Mattey D.L.	2005	HLA-DQA1, HLA-DQB1, HLA-DRB1
22	Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635. (15691524)	Cleare A.J.... Grasby P.M.	2005	HTR1A
23	A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid. (16321154)	Baraniuk J.N.... Hess S S.	2005	APLP1
24	Levels of DHEA and DHEAS and responses to CRH stimulation and hydrocortisone treatment in chronic fatigue syndrome. (15110921)	Cleare A.J.... Miell J.P.	2004	CRH
25	Say NO to fibromyalgia and chronic fatigue syndrome: an alternative and complementary therapy to aerobic exercise. (15193362)	Sackner M.A.... Adams J.A.	2004	NOS3
26	Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndrome. (15490094)	Steinau M.... Rajeevan M.S.	2004	CST7
27	The neuroendocrinology of chronic fatigue syndrome. (12700181)	Cleare A.J.	2003	NR3C1
28	The effect of granisetron, a 5-HT3 receptor antagonis t, in the treatment of chronic fatigue syndrome patients--a pilot study. (14692441)	The G.K.... Van der Meer J.W.	2003	HTR3A
29	Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome. (12851722)	Tanaka S.... Amino N.	2003	DRD2, OPRM1, CHRM1
30	Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome. (12073768)	Snell C.R.... Stevens S.R.	2002	RNASEL
31	Utility of the blood for gene expression profiling and biomarker discovery in chronic fatigue syndrome. (12590173)	Vernon S.D.... Reeves W.C.	2002	CD300C
32	Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy. (11502777)	Cleare A.J.... O'Keane V.	2001	INS, CRH
33	Serum concentrations of some metals and steroids in patients with chronic fatigue syndrome with reference to neurological and cognitive abnormalities. (11470334)	van Rensburg S.J.... Taljaard J.J.	2001	TF
34	Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome. (10751014)	Buskila D.	2000	POMC
35	Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. (10790736)	Pall M.L.	2000	TNF, IFNG
36	A 37 kDa 2-5A binding protein as a potential biochemical marker for chronic fatigue syndrome. (11126321)	De Meirleir K.... Lebleu B.	2000	RNASEL
37	Vitamin B status in patients with chronic fatigue syndrome. (10450194)	Heap L.C.... Wessely S.	1999	GSR, TKT, SLC17A5
38	Dysthymia: clinical picture, extent of overlap with chronic fatigue syndrome, neuropharmacological considerations, and new therapeutic vistas. (10357046)	Brunello N.... Wessely S.	1999	MAOA
39	Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome. (10319275)	Vojdani A.... Lapp C.W.	1999	EIF2AK2
40	Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. (9989716)	Cleare A.J.... Miell J.	1999	INS
41	Desmopressin augments pituitary-adrenal responsivity to corticotropin-releasing hormone in subjects with chronic fatigue syndrome and in healthy volunteers. (10356627)	Scott L.V.... Dinan T.G.	1999	CRH
42	A study of the immunology of the chronic fatigue syndrome: correlation of immunologic parameters to health dysfunction. (9576011)	Hassan I.S.... Bofill M.	1998	LBR
43	The low dose ACTH test in chronic fatigue syndrome and in health. (9713562)	Scott L.V.... Dinan T.G.	1998	POMC
44	Hormonal influences on stress-induced neutrophil mobilization in health and chronic fatigue syndrome. (9710746)	Cannon J.G.... Komaroff A.L.	1998	LTF
45	Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome. (9034999)	Buchwald D.... Kith P.	1997	IL6, IL2, B2M
46	High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome. (9041942)	von Mikecz A.... Tan E.M.	1997	LMNB1
47	Investigation by polymerase chain reaction of enterov iral infection in patients with chronic fatigue syndrome. (8777836)	McArdle A.... Edwards R.H.	1996	CS
48	Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome. (7711161)	Bearn J.... Wessely S.	1995	PRL
49	Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome. (8148461)	Suhadolnik R.J.... Carter W.A.	1994	RNASEL
50	Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome. (1316417)	Linde A.... Lindwall A.	1992	IL2

Genes related to chronic fatigue syndrome according to GeneCards:

(show top 50)    (show all 104)

id	Symbol	Description	Score	GeneCards Section Context
1	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	11.0	Publications
2	SUN2	Sad1 and UNC84 domain containing 2	11.0	Publications
3	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0
4	MAOA	monoamine oxidase A	11.0	Publications
5	CRH	corticotropin releasing hormone	11.0	Publications
6	EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	11.0	Publications
7	LBR	lamin B receptor	11.0	Publications
8	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
9	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
10	POMC	proopiomelanocortin	11.0	Publications
11	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Publications
12	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
13	VIP	vasoactive intestinal peptide	11.0
14	CD300C	CD300c molecule	11.0	Publications
15	CST7	cystatin F (leukocystatin)	11.0	Publications
16	P2RX5	purinergic receptor P2X, ligand-gated ion channel, 5	11.0	Publications
17	ATP5J2	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2	11.0	Publications
18	FCN1	ficolin (collagen/fibrinogen domain containing) 1	11.0	Publications
19	PDCD2	programmed cell death 2	11.0
20	TSPAN3	tetraspanin 3	11.0
21	MRPL23	mitochondrial ribosomal protein L23	11.0
22	TNFRSF17	tumor necrosis factor receptor superfamily, member 17	11.0	Publications
23	P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	11.0	Publications
24	APLP1	amyloid beta (A4) precursor-like protein 1	11.0	Publications
25	IL17F	interleukin 17F	11.0	Publications
26	HTR2B	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	11.0	Publications
27	HTR5A	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	11.0	Publications
28	DUT	deoxyuridine triphosphatase	11.0	Publications
29	SOCS7	suppressor of cytokine signaling 7	11.0
30	IL1R2	interleukin 1 receptor, type II	11.0	Publications
31	HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	11.0	Publications
32	HTR1E	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	11.0	Publications
33	HTR3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	11.0	Publications
34	PDSS1	prenyl (decaprenyl) diphosphate synthase, subunit 1	11.0	Publications
35	PGK1	phosphoglycerate kinase 1	11.0	Publications
36	CHRM1	cholinergic receptor, muscarinic 1	11.0	Publications
37	DISC1	disrupted in schizophrenia 1	11.0	Publications
38	APOBEC3F	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F	11.0
39	MASP2	mannan-binding lectin serine peptidase 2	11.0	Publications
40	HTR7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	11.0	Publications
41	RPLP0	ribosomal protein, large, P0	11.0	Publications
42	LMNB1	lamin B1	11.0	Publications
43	TPH2	tryptophan hydroxylase 2	11.0	Publications
44	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	11.0	Publications
45	SESN1	sestrin 1	11.0
46	NPAS2	neuronal PAS domain protein 2	11.0	Publications
47	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	11.0	Publications
48	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
49	AQPEP	laeverin	11.0
50	CD69	CD69 molecule	11.0	Publications

Pathways related to chronic fatigue syndrome according to GeneDecks:

(show top 50)    (show all 87)

id	Pathway	Score	Top Affiliating Genes
1	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.6	MAOA, SLC6A4, TPH2, HTR6, HTR1A, HTR1E
2	Graft-versus-host disease20	10.5	IL2, HLA-DQA1
3	Bacterial infections in CF airways41	10.5	IL1R1
4	OX40 Pathway36	10.4	LTA, IL4
5	Development Ligand-independent activation of ESR1 and ESR210	10.1	HTR4, ADRB2, HTR7, HTR6, ADRB1
6	PGC1Alpha Pathway36	10.1	CD4, IL4, TNFRSF17, IL2RB, IL1R1, IL2
7	Amine ligand-binding receptors38	10.0	ADRA2A, HTR6, HTR5A, HTR4, HTR2C, HTR2B
8	Antigen processing and presentation20	9.9	CD4, HLA-DRB1, HLA-DQB1, HLA-DQA1
9	Development_Ligand-independent activation of ESR1 and ESR241	9.9	ADRB1, ADRB2, HTR7, HTR6, HTR4, IGF1
10	Calcium signaling pathway20	9.7	CHRM1, HTR6, HTR5A, HTR4, HTR2B, HTR2A
11	Th17 Differentiation37	9.7	TLR4, IL1R1, IL17F, IL6ST, IL6R, IL6
12	Amoebiasis20	9.5	HSPB1, IL6, IL1R2, TLR4, NOS2, IL1R1
13	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	IL6ST, TLR4, IFNG, IL6R, IL6, IL17F
14	Immune response IL-22 signaling pathway10	9.4	CD4, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL2RB, IL2
15	Immune System38	9.2	AGER, IL6ST, IL1R1, IL1R2, IL6R, IFNG
16	Jak-STAT signaling pathway20	9.0	IL10, SOCS7, PRL, GH1, IL6ST, IL6R
17	Hematopoietic cell lineage20	9.0	IL1R1, CD4, IL4, IL6, HLA-DRB1, TNF
18	Autoimmune thyroid disease20	9.0	HLA-DQA1, IL10, IL2, IL4, HLA-DRB1, HLA-DQB1
19	Asthma20	8.9	IL10, IL4, HLA-DQB1, HLA-DRB1, TNF, RNASE3
20	Neuroactive ligand-receptor interaction20	8.9	CHRM1, NR3C1, DRD2, GH1, HTR7, HTR6
21	Th1 Differentiation37	8.9	IFNG, TNF, IL10, CD4, TLR4, IL6ST
22	Glucocorticoid Receptor Signaling36	8.8	IL10, IL1R1, IL2, IL2RB, IL4, IL6
23	Intestinal immune network for IgA production20	8.7	IL10, IL2, IL4, IL6, HLA-DQA1, HLA-DQB1
24	Intracellular Calcium Signaling36	8.7	HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4
25	NF-KappaB (p50-p65) Pathway36	8.7	TLR4, GH1, IL6, IL1R2, IL1R1, IGF1
26	NF-KappaB Family Pathway36	8.6	IL1R2, IL2, IL6, IGF2, IGF1, GH1
27	Immune response MIF-mediated glucocorticoid regulation10	8.6	IL2, IL6, IFNG, NOS2, NR3C1, PTGS2
28	Immune response_MIF-mediated glucocorticoid regulation41	8.6	NOS2, NR3C1, PTGS2, TNF, IFNG, IL6
29	Influenza A20	8.6	HLA-DRB1, TLR4, EIF2AK2, IL6, IFNG, HLA-DQA1
30	Immune response_MIF in innate immunity response41	8.5	TLR4, NOS2, PTGS2, TNF, IFNG, IL6
31	Immune response MIF in innate immunity response10	8.5	NOS2, TLR4, PTGS2, TNF, IL6, IFNG
32	Akt Signaling36	8.5	IL2, LTA, TNF, IL6, IL4, IL2RB
33	Cytokine Network36	8.5	IL2, IFNG, LTA, TNF, IL6, IL4
34	Allograft rejection20	8.5	IL10, HLA-DRB1, IL2, TNF, IL4, HLA-DQA1
35	THC Differentiation Pathway36	8.5	IL10, TNF, IL2, IL4, IFNG, HLA-DQA1
36	Rheumatoid arthritis20	8.4	TNF, HLA-DRB1, TLR4, HLA-DQB1, HLA-DQA1, IFNG
37	Type I diabetes mellitus20	8.4	TNF, HLA-DRB1, IL2, HLA-DQB1, HLA-DQA1, LTA
38	STAT3 Pathway36	8.3	IL2RB, IL1R1, IL10, TNF, IL4, IL6R
39	TGF-Beta Pathway36	8.2	IGF2, IL1R1, CD4, IL2, IL2RB, IL10
40	MIF Mediated Glucocorticoid Regulation36	8.2	IL4, TNF, IL10, IL2, NR3C1, TLR4
41	Toxoplasmosis20	8.1	HLA-DQB1, HLA-DQA1, TNF, NOS2, TLR4, IL10
42	MIF Regulation of Innate Immune Cells36	8.1	TLR4, LTA, PTGS2, TNF, IL4, IL6
43	Leishmaniasis20	7.8	HLA-DQA1, HLA-DRB1, PTGS2, TLR4, TNF, NOS2
44	Antioxidant Action of Vitamin-C36	7.7	CD4, IL6R, LTA, IL10, IL1R1, IL2
45	Tuberculosis20	7.7	HLA-DRB1, TNF, NOS2, TLR4, HLA-DQB1, IL10
46	Tec Kinases Signaling36	7.7	GH1, IL6, IGF1, TLR4, TNFRSF17, TNF
47	MAPK Family Pathway36	7.6	IL6, IL4, IL2RB, IL2, IL1R1, IL10
48	p38 Signaling36	7.6	IL2, IL1R2, IL1R1, IL10, CD4, IGF2
49	Cytokine-cytokine receptor interaction20	7.5	IL6R, IL1R1, TNF, IL10, PRL, LTA
50	JAK-STAT Pathway36	7.5	IL6R, IL4, GH1, IL6, TNFRSF17, PRL

Compounds related to chronic fatigue syndrome according to GeneDecks:

(show top 50)    (show all 465)

id	Compound	Score	Top Affiliating Genes
1	bromocriptine32 9 9	11.8	VIP, HTR1A, HTR2A, HTR2B, HTR2C, HTR7
2	pge232	9.8	VIP, CD69, CD4, GSR, IL1R1, CRH
3	corticosterone32 18	10.7	SERPINA6, VIP, IL1R1, IGFBP1, IGF2, GH1
4	mirtazapine32 34 9 9	12.6	HTR2A, HTR2C, HTR3A, TPH2, NR3C1, CRH
5	testosterone32 9 18 9	12.5	SERPINA6, VIP, LBR, B2M, IL1R1, IL6R
6	quetiapine32 9 18 9	12.4	CHRM1, HTR1A, HTR1E, HTR2A, HTR2B, HTR2C
7	fenfluramine32 9 9	11.3	IGF2, IGFBP3, HTR1A, HTR2A, HTR2B, HTR2C
8	gaba32 42	10.3	VIP, CHRM1, GSR, GRIK2, MAOA, HTR2C
9	dopamine32 9 18 9	12.2	VIP, CHRM1, GRIK2, MAOA, HTR1A, HTR2B
10	risperidone32 34 9 18 9	13.1	HTR1A, HTR2A, HTR2C, HTR3A, HTR6, DRD2
11	ziprasidone32 9 9	11.1	CHRM1, HTR1A, HTR1E, HTR2A, HTR2C, HTR3A
12	aspartate32	9.1	VIP, B2M, GSR, IL2RB, GH1, ERVK-6
13	5-hydroxytryptamine32	9.1	VIP, CHRM1, MAOA, HTR1A, HTR1E, HTR2A
14	cysteine32	9.1	SERPINA6, LMNB1, LBR, CD4, IGF2, IGFBP3
15	fluticasone propionate32 42 9 9	12.0	SERPINA6, IL4, IGFBP3, IGHE, IFNG, TNF
16	aripiprazole32 34 9 18 9	12.9	CHRM1, HTR1A, HTR1E, HTR2A, HTR2C, HTR3A
17	gnrh32	8.9	CD69, INS, IGFBP1, IGFBP3, IGF1, HTR2C
18	naltrexone32 34 9 9	11.8	LBR, IGFBP3, IGF1, GH1, CRH, PRL
19	ascorbic acid32 18	9.6	IL1R1, ANXA5, MAOA, IGF2, IGFBP3, IGHE
20	cabergoline32 9 9	10.6	IGFBP3, IGF1, HTR1A, HTR2A, HTR2B, HTR2C
21	creatinine32	8.5	B2M, CD69, IL1R1, IL2RB, IL6R, IGFBP1
22	acetylcholine32 9 18 9	11.5	VIP, CHRM1, LBR, IGHE, HTR1A, HTR2C
23	olanzapine32 34 9 18 9	12.2	CHRM1, INS, HTR1A, HTR1E, HTR2A, HTR2B
24	octreotide32 42 9 9	11.2	VIP, INS, IGFBP1, IGF2, IGFBP3, IGF1
25	epinephrine32 9 18 9	11.1	VIP, LBR, CD69, INS, GSR, IGFBP1
26	acth32	8.0	SERPINA6, VIP, INS, IL1R1, IL2RB, IL6
27	infliximab32 9 9	9.9	LBR, IL10, IL1R1, IL2RB, IL4, IL6
28	glutamine32	7.8	VIP, B2M, GRIK2, IL6R, IGF2, IGFBP3
29	cyclosporin a32 42	8.8	VIP, LBR, B2M, CD69, IL10, IL1R1
30	vegf32	7.8	VIP, IL1R1, IL6R, IL6ST, IGFBP1, IGF2
31	adenylate32	7.6	SERPINA6, VIP, CHRM1, GSR, IL1R1, IL4
32	nitric oxide32 9 18 9	10.6	CHRM1, IL10, IL1R1, IL2RB, IL6, IGFBP1
33	glutamate32	7.5	VIP, CHRM1, CD4, INS, GSR, GRIK2
34	histamine32 18	8.2	VIP, LBR, IL10, IL2, IL2RB, IL4
35	arginine32	6.9	SERPINA6, VIP, CHRM1, LBR, INS, GSR
36	methotrexate32 34 42 9 9	10.9	CD69, GSR, IL10, IL1R1, IL2RB, IL6
37	alanine32	6.9	SERPINA6, VIP, CHRM1, B2M, CD4, INS
38	thyroxine32 18	7.8	SERPINA6, VIP, B2M, INS, GSR, IL10
39	prednisolone32 9 9	8.8	SERPINA6, VIP, IL10, IL1R1, IL2, IL2RB
40	thymidine32 18	7.8	VIP, LBR, B2M, CD69, IL10, IL1R1
41	genistein32 9 18 9	9.7	CHRM1, LBR, B2M, CD69, CD4, GSR
42	actinomycin d32	6.6	CD69, IL1R1, IL2, IL4, IL6, ANXA5
43	indomethacin32 9 9	8.6	VIP, B2M, GSR, IL1R1, IL2, IL4
44	lactate32	6.3	VIP, B2M, INS, GSR, IL1R1, IL2RB
45	retinoic acid32 42 18	8.2	LBR, B2M, GRIK2, IL1R1, IL2RB, IL6
46	norepinephrine32 9 18 9	9.1	VIP, LBR, INS, IL1R1, IL2RB, IL6
47	serine32	6.0	SERPINA6, VIP, LBR, B2M, CD69, CD4
48	hydrocortisone32 9 9	7.9	SERPINA6, INS, IL10, IL1R1, IL2, IL4
49	tyrosine32	5.4	VIP, LMNB1, CHRM1, LBR, CD69, CD4
50	cycloheximide32	5.4	LBR, B2M, CD69, CD4, IL10, IL1R1

Cellular components related to chronic fatigue syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-6 receptor complex	GO:005896	9.5	IL6ST, IL6R, IL6
2	secretory granule	GO:030141	9.2	INS, LTF, ELANE, TF, POMC
3	external side of plasma membrane	GO:009897	8.4	TLR4, TNF, HLA-DRB1, IFNG, ANXA5, IL6ST
4	integral to plasma membrane	GO:005887	7.1	ADRA2A, HTR6, HTR7, HLA-DQA1, HLA-DRB1, TNF
5	extracellular region	GO:005576	6.1	ELANE, LTF, RNASE3, CRH, GH1, AGER
6	extracellular space	GO:005615	6.0	IGFBP3, IGF1, IFNG, GH1, TNF, CRH
7	plasma membrane	GO:005886	5.7	DISC1, DRD2, TNFRSF17, TNF, HLA-DRB1, HLA-DQB1

Biological processes related to chronic fatigue syndrome according to GeneDecks:

(show all 45)

id	Name	GO ID	Score	Top Affiliating Genes
1	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:007187	10.6	NPY, HTR1E, HTR4, HTR5A, HTR6, HTR7
2	serotonin receptor signaling pathway	GO:007210	10.4	HTR1E, HTR5A, HTR4, HTR3A, HTR2C, HTR2B
3	release of sequestered calcium ion into cytosol	GO:051209	10.2	DRD2, HTR2C, HTR2B, HTR2A
4	positive regulation of activated T cell proliferation	GO:042104	10.1	IGF1, IGF2, IL4, IL2
5	interleukin-6-mediated signaling pathway	GO:070102	10.1	IL6ST, IL6R, IL6
6	positive regulation of isotype switching to IgG isotypes	GO:048304	10.1	IL2, IL4, IFNG
7	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.1	GH1, IGF1, IL4, IL2
8	positive regulation of interleukin-8 biosynthetic process	GO:045416	10.0	TNF, ELANE, TLR4
9	negative regulation of synaptic transmission, glutamatergic	GO:051967	10.0	DRD2, HTR2A, GRIK2
10	positive regulation of MAP kinase activity	GO:043406	9.9	ADRA2A, ELANE, TNF, GH1, HTR2B, HTR2A
11	synaptic transmission	GO:007268	9.9	NPY, COMT, CRH, HTR7, HTR6, HTR3B
12	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	9.9	GH1, IL6ST, IL6R, IL6
13	feeding behavior	GO:007631	9.8	NPY, CRH, DRD2, HTR2C
14	negative regulation of smooth muscle cell proliferation	GO:048662	9.8	COMT, NOS3, IFNG, IGFBP3
15	response to cytokine stimulus	GO:034097	9.8	NOS3, PTGS2, IL6ST, IL6R, IL4
16	positive regulation of interferon-gamma production	GO:032729	9.8	TLR4, LTA, TNF, IL2
17	positive regulation of chemokine biosynthetic process	GO:045080	9.7	IL4, IFNG, TNF
18	positive regulation of chemokine production	GO:032722	9.7	TLR4, TNF, IL6R, IL6
19	G-protein coupled receptor signaling pathway	GO:007186	9.7	ADRA2A, HTR5A, HTR4, HTR2B, HTR1E, HTR1A
20	defense response to Gram-negative bacterium	GO:050829	9.7	TLR4, NOS2, IL6R, IL6, CD4
21	T cell costimulation	GO:031295	9.6	DPP4, HLA-DRB1, HLA-DQB1, HLA-DQA1, CD4
22	response to activity	GO:014823	9.6	TLR4, NR3C1, TNF, TPH2, IL10
23	positive regulation of MHC class II biosynthetic process	GO:045348	9.5	TLR4, IFNG, IL4, IL10
24	cellular component movement	GO:006928	9.5	ADRA2A, NPY, PTGS2, HSPB1, IFNG, IGF1
25	interferon-gamma-mediated signaling pathway	GO:060333	9.5	B2M, IFNG, HLA-DQA1, HLA-DQB1, HLA-DRB1
26	defense response to Gram-positive bacterium	GO:050830	9.4	IL6, IL6R, TNF, LTA
27	negative regulation of growth of symbiont in host	GO:044130	9.3	ELANE, LTA, TNF, IFNG, IL10
28	humoral immune response	GO:006959	9.3	LTF, LTA, TNF, IFNG, IL6
29	positive regulation of interleukin-6 production	GO:032755	9.3	TLR4, TNF, IL6R, IL6
30	response to hypoxia	GO:001666	9.3	SLC6A4, DPP4, TLR4, LTA, NOS3, NOS2
31	immune response	GO:006955	9.2	CST7, TLR4, HLA-DRB1, HLA-DQB1, HLA-DQA1, IGHE
32	positive regulation of smooth muscle cell proliferation	GO:048661	9.1	ELANE, PTGS2, TNF, IGF1, IL6R, IL6
33	defense response to bacterium	GO:042742	9.1	TLR4, LTF, RNASE3, NOS2, IFNG, IL10
34	positive regulation of mitosis	GO:045840	9.1	TNF, IGF1, IGF2, INS
35	cytokine-mediated signaling pathway	GO:019221	9.0	RNASEL, HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG, IL6ST
36	anti-apoptosis	GO:006916	8.9	NOS3, NR3C1, TNF, HSPB1, IGF1, ANXA5
37	positive regulation of cytokine secretion	GO:050715	8.9	TNF, HTR2B, IL10, INS
38	positive regulation of MAPK cascade	GO:043410	8.8	ADRB2, IGF1, IGFBP3, IGF2, IL6R, IL6
39	positive regulation of nitric oxide biosynthetic process	GO:045429	8.7	TLR4, PTGS2, TNF, IFNG, INS, P2RX4
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.7	TLR4, AGER, TNF, IL6R, IL6, INS
41	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.5	TLR4, GH1, IGF1, IGF2, IL6R, IL6
42	positive regulation of apoptotic process	GO:043065	8.5	ADRB2, TLR4, NOS3, PTGS2, TNF, IGFBP3
43	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.3	ADRB2, NPAS2, POMC, TLR4, RNASEL, DRD2
44	positive regulation of cell proliferation	GO:008284	8.3	HTR1A, HTR2A, HTR2B, HTR4, DPP4, ADRB2
45	response to drug	GO:042493	7.7	DRD2, PTGS2, NOS3, COMT, LTA, SLC6A4

Molecular functions related to chronic fatigue syndrome according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	10.5	ADCYAP1, NPY, CRH, VIP
2	norepinephrine binding	GO:051380	10.4	ADRB2, ADRB1, ADRA2A
3	epinephrine binding	GO:051379	10.4	ADRA2A, ADRB1, ADRB2
4	serotonin binding	GO:051378	10.4	HTR3A, HTR2C, HTR2B, HTR2A, HTR1E, HTR1A
5	serotonin receptor activity	GO:004993	10.2	HTR1A, HTR7, HTR5A, HTR4, HTR3B, HTR3A
6	phosphatidylinositol phospholipase C activity	GO:004435	10.1	CHRM1, HTR2A, HTR2B, HTR2C
7	transmembrane signaling receptor activity	GO:004888	10.0	TLR4, AGER, IL1R1, CD300C, CD4, CD69
8	interleukin-6 receptor binding	GO:005138	10.0	IL6ST, IL6R, IL6
9	receptor binding	GO:005102	9.9	ADCYAP1, NPY, POMC, DPP4, LTA, NOS2
10	drug binding	GO:008144	9.9	ADRB1, ADRB2, DRD2, HTR2C, HTR2B, HTR2A
11	dopamine binding	GO:035240	9.7	ADRB1, ADRB2, DRD2
12	protease binding	GO:002020	9.1	DPP4, ELANE, TNF, IL1R1, INS
13	hormone activity	GO:005179	9.0	POMC, PRL, CRH, GH1, IGF1, IGF2
14	protein homodimerization activity	GO:042803	8.8	NOS2, TKT, DPP4, SLC6A4, ADRB2, ADRA2A
15	cytokine activity	GO:005125	8.3	LTA, TNF, IFNG, IL6, IL4, IL2
16	growth factor activity	GO:008083	8.2	GH1, IGF1, IGF2, IL6, IL4, IL2
17	protein binding	GO:005515	5.3	EIF2AK2, LTF, RPLP0, NOS3, NOS2, CRH