CFS
MCID: CHR066
MIFTS: 65

Chronic Fatigue Syndrome (CFS) malady

Neuronal diseases category

Summaries for Chronic Fatigue Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Chronic fatigue syndrome (cfs) is a disorder that causes extreme fatigue. this fatigue is not the kind of tired feeling that goes away after you rest. instead, it lasts a long time and limits your ability to do ordinary daily activities. the main symptom of cfs is severe fatigue that lasts for 6 months or more. you also have at least four of these other symptoms: feeling unwell for more than 24 hours after physical activity muscle pain memory problems headaches pain in multiple joints sleep problems sore throat tender lymph nodes cfs is hard to diagnose. there are no tests for it, and other illnesses can cause similar symptoms. your doctor has to rule out other diseases before making a diagnosis of cfs. no one knows what causes cfs. it is most common in women in their 40s and 50s, but anyone can have it. it can last for years. there is no cure for cfs, so the goal of treatment is to improve symptoms. medicine may treat pain, sleep disorders, and other problems. lifestyle changes, coping techniques, and a special, gradual exercise program can also help. centers for disease control and prevention

MalaCards: Chronic Fatigue Syndrome, also known as myalgic encephalomyelitis, is related to leukemia and arthritis. An important gene associated with Chronic Fatigue Syndrome is RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and SIDS Susceptibility Pathways. The drugs fish oils and coenzyme q10 and the compounds testosterone and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and prostate, and related mouse phenotypes are immune system and behavior/neurological.

Disease Ontology:8 A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to extertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.

NIH Rare Diseases:42 Chronic fatigue syndrome is a condition that causes extreme, long-lasting fatigue which can limit the ability to participate in ordinary, daily activities. it generally occurs in young adults between the ages of 20 and 40. the main symptom of this condition is disabling fatigue that does not improve with rest. other signs and symptoms may include muscle pain; joint pain; concentration and memory problems; headaches; sleep problems; fever; sore throat; and/or tender lymph nodes. the exact cause of chronic fatigue syndrome is not known, but it has been proposed that infectious agents, immune system impairment and/or hormonal system deregulation may be involved. there is no cure for this condition; the goal of treatment is to improve symptoms. medications may be used to treat pain, sleep disorders and other associated problems. last updated: 10/14/2013

CDC:3 Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms affect several body systems and may include weakness, muscle pain, impaired memory and/or mental concentration, and insomnia, which can result in reduced participation in daily activities.

Wikipedia:63 Chronic fatigue syndrome (CFS) is the common name for a group of significantly debilitating medical... more...

Aliases & Classifications for Chronic Fatigue Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

chronic fatigue syndrome 8 42 10 44 33 60
myalgic encephalomyelitis 8 42
postviral fatigue syndrome 8
myalgic encephalitis 8
cfs 8


Related Diseases for Chronic Fatigue Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chronic Fatigue Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0EIF2AK2, RNASEL, IGFBP1, NR3C1, LBR
2arthritis30.5ADCYAP1, POMC, VIP
3rheumatoid arthritis30.5ADCYAP1, NR3C1, CRH, LBR, TNFRSF17, VIP
4addison's disease30.5POMC, CRH
5seasonal affective disorder30.4HTR1A, CRH, SLC6A4
6anorexia nervosa30.2HTR1A, CRH, IGFBP1, POMC, MAOA, SLC6A4
7multiple sclerosis30.2ADCYAP1, EIF2AK2, POMC, LBR, TNFRSF17
8migraine30.2ADCYAP1, SLC6A4, MAOA, HTR1A, HTR2B, VIP
9attention deficit hyperactivity disorder30.2SLC6A4, MAOA
10personality disorder30.2MAOA, SLC6A4
11obesity30.0MAOA, POMC, IGFBP1, NR3C1, CRH, HTR1A
12dementia30.0MAOA, NR3C1, HTR1A
13anxiety disorder30.0HTR1A, CRH, MAOA, SLC6A4
14hepatitis30.0IGFBP1
15ischemia30.0ADCYAP1, HTR1A, VIP
16schizophrenia30.0HTR1A, LBR, NR3C1, MAOA, SLC6A4, ADCYAP1
17irritable bowel syndrome30.0SLC6A4, CRH
18generalized anxiety disorder30.0HTR1A, SLC6A4
19persian gulf syndrome30.0VIP, ADCYAP1
20hypoglycemia30.0POMC, IGFBP1, CRH
21encephalomyelitis10.9
22prostate cancer10.5
23prostatitis10.5
24myofascial pain syndrome10.5
25multiple chemical sensitivity10.5
26bronchiectasis10.4
27adult syndrome10.4
28borna disease10.4
29infectious mononucleosis10.4
30cerebritis10.3
31encephalitis10.3
32arts syndrome10.3
33sleep disorder10.3
34image syndrome10.3
35orchitis10.2
36major depressive disorder10.2
37cystic fibrosis10.2
38sick building syndrome10.2
39chronic rhinitis10.2
40giardiasis10.2
41ehlers-danlos syndrome10.2
42influenza10.2
43rhinitis10.2
44infertility10.1
45esophageal cancer10.1
46esophagitis10.1
47pancreatitis10.1
48cftr-related disorders10.1
49lassa fever10.0
50arthropathy10.0

Graphical network of the top 20 diseases related to Chronic Fatigue Syndrome:



Diseases related to chronic fatigue syndrome

Clinical Features for Chronic Fatigue Syndrome

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Drugs & Therapeutics for Chronic Fatigue Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Fatigue Syndrome

Drug clinical trials:

Search ClinicalTrials for Chronic Fatigue Syndrome

Search NIH Clinical Center for Chronic Fatigue Syndrome

Search CenterWatch for Chronic Fatigue Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Chronic Fatigue Syndrome

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Anatomical Context for Chronic Fatigue Syndrome

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32MalaCards
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MalaCards organs/tissues related to Chronic Fatigue Syndrome:

32
Lymph node, Testes, Prostate, Pituitary, Brain, Heart, Whole blood, Endothelial, B cells, T cells, Skin, Skeletal muscle, Eye

Animal Models for Chronic Fatigue Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Chronic Fatigue Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6ADCYAP1, VIP, TNFRSF17, LBR, CRH, NR3C1
2MP:000538610.6LBR, HTR5A, HTR1A, VIP, CRH, NR3C1
3MP:000537610.5HTR1A, LBR, CRH, NR3C1, POMC, MAOA
4MP:000287310.5VIP, CST7, TNFRSF17, HTR2B, HTR5A, CRH
5MP:000539710.4TNFRSF17, LBR, CRH, NR3C1, POMC, RNASEL
6MP:001076810.2VIP, HTR2B, HTR1A, LBR, NR3C1, POMC

Publications for Chronic Fatigue Syndrome

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Sources:
50PubMed
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Articles related to Chronic Fatigue Syndrome:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort. (24206536)
2013
2
Depression in paediatric chronic fatigue syndrome. (23619200)
2013
3
Chronic fatigue syndrome. (23312650)
2013
4
Dyspnea in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies. (23445698)
2013
5
In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation. (23664637)
2013
6
Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome. (24054763)
2013
7
News from the CDC: chronic fatigue syndrome (CFS) and standardized patient videosa88-a88a novel approach to educating medical students about CFS. (24294321)
2013
8
Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis. (23794547)
2013
9
Mindfulness-based cognitive therapy for people with chronic fatigue syndrome still experiencing excessive fatigue after cognitive behaviour therapy: a pilot randomized study. (21983916)
2013
10
Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course. (23399438)
2013
11
Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome. (24027260)
2013
12
Factors affecting duration of chronic fatigue syndrome in pediatric patients. (21617905)
2012
13
Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins. (22112145)
2012
14
Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome. (22842604)
2012
15
A review of the definitional criteria for chronic fatigue syndrome. (21029269)
2012
16
Test effort in persons with Chronic Fatigue Syndrome when assessed using the Validity Indicator Profile. (22440059)
2012
17
Attention-deficit hyperactivity disorder in chronic fatigue syndrome patients. (22648008)
2012
18
Stress management skills, neuroimmune processes and fatigue levels in persons with chronic fatigue syndrome. (22417946)
2012
19
Immunologic and psychosocial status in chronic fatigue syndrome. (21585130)
2011
20
Researcher into chronic fatigue syndrome is released on bail. (22121165)
2011
21
Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome. (21912186)
2011
22
Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus. (21472770)
2011
23
The role of acceptance in chronic fatigue syndrome. (22118384)
2011
24
Science asks researchers to withdraw paper on chronic fatigue syndrome and infectious retrovirus. (21646307)
2011
25
The PACE trial in chronic fatigue syndrome. (21592560)
2011
26
Failure to confirm XMRV/MLVs in the blood of patients with chronic fatigue syndrome: a multi-laboratory study. (21940862)
2011
27
Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis. (22044797)
2011
28
Dangers of research into chronic fatigue syndrome. (21697226)
2011
29
Fatigue In Teenagers on the interNET--the FITNET Trial. A randomized clinical trial of web-based cognitive behavioural therapy for adolescents with chronic fatigue syndrome: study protocol. [ISRCTN59878666]. (21333021)
2011
30
Premorbid risk markers for chronic fatigue syndrome in the 1958 British birth cohort. (21852302)
2011
31
Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression. (21552194)
2011
32
Sleep-wake behavior in chronic fatigue syndrome. (21532961)
2011
33
Sleep stage transitions in chronic fatigue syndrome patients with or without fibromyalgia. (21096267)
2010
34
Nurse-delivered, home-based pragmatic rehabilitation has a short-term effect on improving fatigue in people with chronic fatigue syndrome compared with usual GP care, but effects were not sustained at 1 year. (20855345)
2010
35
Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26. (20520837)
2010
36
No differences in cardiovascular autonomic responses to mental stress in chronic fatigue syndrome adolescents as compared to healthy controls. (21156045)
2010
37
Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome. (21190576)
2010
38
Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study. (20878051)
2010
39
Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder. (20661876)
2010
40
Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome. (19015737)
2009
41
Plasma cytokines in women with chronic fatigue syndrome. (19909538)
2009
42
Defining the occurrence and influence of alpha-delta sleep in chronic fatigue syndrome. (17301585)
2007
43
Overlap between atypical depression, seasonal affective disorder and chronic fatigue syndrome]. (17546343)
2007
44
The neuroendocrinology of chronic fatigue syndrome. (12700181)
2003
45
Abnormalities in response to vasopressin infusion in chronic fatigue syndrome. (11087963)
2001
46
Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. (12000033)
2001
47
Fibromyalgia, chronic fatigue syndrome, and myofascial pain. (9567202)
1998
48
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome. (7893988)
1994
49
Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome. (8024971)
1994
50
Serum angiotensin-converting enzyme as a marker for the chronic fatigue-immune dysfunction syndrome: a comparison to serum angiotensin-converting enzyme in sarcoidosis. (8213873)
1993

Genetic Variations for Chronic Fatigue Syndrome

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Expression for genes affiliated with Chronic Fatigue Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Fatigue Syndrome

Search GEO for disease gene expression data for Chronic Fatigue Syndrome.

Pathways for genes affiliated with Chronic Fatigue Syndrome

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Chronic Fatigue Syndrome

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2414.0POMC, IGFBP1, NR3C1, CRH, LBR, VIP
2norepinephrine44 11 2413.0IGFBP1, CRH, POMC, MAOA, SLC6A4, ADCYAP1
3corticosterone44 59 2413.0NR3C1, HTR1A, VIP, CRH, IGFBP1, POMC
45-hydroxytryptamine4411.0HTR1A, CRH, POMC, MAOA, SLC6A4, ADCYAP1
5epinephrine44 11 2413.0LBR, MAOA, SLC6A4, VIP, CRH, IGFBP1
6dopamine44 28 11 2414.0NR3C1, HTR2B, HTR1A, CRH, POMC, MAOA
7sertraline44 28 49 11 2414.9HTR1A, CRH, MAOA, SLC6A4, POMC
8fenfluramine28 44 1112.9SLC6A4, POMC, CRH, HTR2B, HTR1A
9acth4410.9CRH, ADCYAP1, POMC, IGFBP1, NR3C1, HTR1A
10clomipramine44 49 1112.9SLC6A4, HTR2B, HTR1A, CRH, MAOA
11gaba4410.9NR3C1, ADCYAP1, SLC6A4, MAOA, VIP, POMC
12desipramine44 49 1112.9HTR1A, CRH, NR3C1, MAOA, SLC6A4
13haloperidol44 28 2 49 1114.9VIP, HTR2B, ADCYAP1, HTR1A, POMC, SLC6A4
14sumatriptan44 28 59 49 11 2415.9VIP, HTR2B, HTR1A, MAOA, HTR5A
15arginine4410.9LBR, CRH, RNASEL, IGFBP1, POMC, SLC6A4
16fluoxetine49 44 28 1113.9MAOA, HTR1A, HTR2B, CRH, SLC6A4
17acetylcholine44 49 28 11 2414.9LBR, ADCYAP1, POMC, NR3C1, CRH, HTR1A
18mirtazapine49 44 1112.9SLC6A4, POMC, NR3C1, CRH
19methiothepin44 2811.9NR3C1, HTR1A, HTR2B, HTR5A
20metergoline44 2811.9NR3C1, HTR5A, HTR2B, HTR1A
21maoa4410.9MAOA, SLC6A4, HTR1A, POMC
22methysergide44 28 1112.9MAOA, HTR1A, HTR5A, HTR2B
23mianserin28 44 1112.9MAOA, HTR1A, SLC6A4, HTR2B
245-hydroxyindoleacetic acid44 2411.9VIP, CRH, MAOA, SLC6A4
25cycloheximide4410.9IGFBP1
26ketanserin28 4411.9SLC6A4, HTR1A, HTR2B, HTR5A
27mifepristone44 59 28 1113.9POMC, CRH, NR3C1, IGFBP1, LBR
28dexamethasone44 49 28 1113.9IGFBP1, POMC, NR3C1, MAOA, CRH, VIP
29clozapine44 28 49 1113.8POMC, HTR1A, HTR2B, HTR5A, SLC6A4
30catecholamine4410.8VIP, ADCYAP1, MAOA, POMC, CRH
31gnrh4410.8IGFBP1, ADCYAP1, VIP
32carbon-114410.8HTR1A, MAOA, SLC6A4
33p-chloroamphetamine4410.8SLC6A4, MAOA, HTR1A
34yohimbine44 28 2 1113.8HTR2B, CRH, HTR5A, HTR1A
35aspartate4410.8VIP, ADCYAP1, EIF2AK2, SLC6A4, POMC, NR3C1
36m-chlorophenylpiperazine4410.8HTR2B, SLC6A4, HTR1A
37naratriptan44 28 1112.8NR3C1, HTR1A, MAOA
38serine4410.8ADCYAP1, POMC, EIF2AK2, SLC6A4, VIP
39mcpp4410.7HTR2B, SLC6A4, HTR1A
40carbachol44 28 1112.7NR3C1, CRH, LBR, VIP, ADCYAP1
41ru 2496928 4411.7HTR1A, HTR5A, HTR2B
42dihydrotestosterone44 28 11 2413.7ADCYAP1, IGFBP1, NR3C1, VIP, SLC6A4
43bromocriptine28 44 1112.7POMC, VIP, HTR1A
44citalopram49 44 11 2413.6SLC6A4, MAOA, HTR1A
458-oh-dpat2810.6HTR1A, HTR5A, HTR2B
46astressin44 28 5912.6VIP, ADCYAP1, CRH
47mdma4410.5SLC6A4, MAOA, HTR1A
48minaprine44 1111.5HTR2B, MAOA, SLC6A4
495-ct2810.4HTR5A, HTR1A, HTR2B
50pindolol44 28 1112.2SLC6A4, HTR2B, HTR1A

GO Terms for genes affiliated with Chronic Fatigue Syndrome

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16Gene Ontology
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Cellular components related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5SLC6A4, P2RX5, CD300C, HTR5A, HTR1A, HTR2B
2extracellular regionGO:00557610.2ADCYAP1, VIP, CST7, CRH, IGFBP1, POMC

Biological processes related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.7HTR5A, HTR1A, HTR2B
2vasoconstrictionGO:04231010.7SLC6A4, HTR1A, HTR2B
3regulation of serotonin secretionGO:01406210.6HTR1A, CRH
4positive regulation of cell proliferationGO:00828410.6ADCYAP1, CRH, HTR1A, HTR2B, VIP
5positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5VIP, ADCYAP1
6signal transductionGO:00716510.5P2RX5, POMC, IGFBP1, NR3C1, CRH, TNFRSF17
7G-protein coupled receptor signaling pathwayGO:00718610.5HTR5A, HTR1A, HTR2B, VIP
8regulation of behaviorGO:05079510.4HTR2B, HTR1A
9negative regulation of potassium ion transportGO:04326710.2VIP, ADCYAP1

Molecular functions related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.5POMC, CRH, VIP
2neuropeptide hormone activityGO:00518410.5ADCYAP1, CRH, VIP
3serotonin receptor activityGO:00499310.4HTR2B, HTR1A, HTR5A
4lamin bindingGO:00552110.2SUN2, LBR

Products for genes affiliated with Chronic Fatigue Syndrome

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  • Antibodies
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  • Antibodies

Sources for Chronic Fatigue Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet