CFS
MCID: CHR066
MIFTS: 63

Chronic Fatigue Syndrome (CFS) malady

Neuronal category

Summaries for Chronic Fatigue Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Chronic fatigue syndrome (cfs) is a disorder that causes extreme fatigue. this fatigue is not the kind of tired feeling that goes away after you rest. instead, it lasts a long time and limits your ability to do ordinary daily activities. the main symptom of cfs is severe fatigue that lasts for 6 months or more. you also have at least four of these other symptoms: feeling unwell for more than 24 hours after physical activity muscle pain memory problems headaches pain in multiple joints sleep problems sore throat tender lymph nodes cfs is hard to diagnose. there are no tests for it, and other illnesses can cause similar symptoms. your doctor has to rule out other diseases before making a diagnosis of cfs. no one knows what causes cfs. it is most common in women in their 40s and 50s, but anyone can have it. it can last for years. there is no cure for cfs, so the goal of treatment is to improve symptoms. medicine may treat pain, sleep disorders, and other problems. lifestyle changes, coping techniques, and a special, gradual exercise program can also help. centers for disease control and prevention

MalaCards: Chronic Fatigue Syndrome, also known as myalgic encephalomyelitis, is related to fibromyalgia and arthritis. An important gene associated with Chronic Fatigue Syndrome is RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and SIDS Susceptibility Pathways. The drugs fish oils and venlafaxine and the compounds testosterone and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are immune system and behavior/neurological.

Disease Ontology:8 A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to extertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.

NIH Rare Diseases:43 Chronic fatigue syndrome is a condition that causes extreme, long-lasting fatigue which can limit the ability to participate in ordinary, daily activities. it generally occurs in young adults between the ages of 20 and 40. the main symptom of this condition is disabling fatigue that does not improve with rest. other signs and symptoms may include muscle pain; joint pain; concentration and memory problems; headaches; sleep problems; fever; sore throat; and/or tender lymph nodes. the exact cause of chronic fatigue syndrome is not known, but it has been proposed that infectious agents, immune system impairment and/or hormonal system deregulation may be involved. there is no cure for this condition; the goal of treatment is to improve symptoms. medications may be used to treat pain, sleep disorders and other associated problems. last updated: 10/14/2013

CDC:3 Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms affect several body systems and may include weakness, muscle pain, impaired memory and/or mental concentration, and insomnia, which can result in reduced participation in daily activities.

Wikipedia:64 Chronic fatigue syndrome (CFS) is the common name for a group of significantly debilitating medical... more...

Aliases & Classifications for Chronic Fatigue Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

chronic fatigue syndrome 8 43 10 45 34 61
myalgic encephalomyelitis 8 43
postviral fatigue syndrome 8
myalgic encephalitis 8
cfs 8


Related Diseases for Chronic Fatigue Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Chronic Fatigue Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1fibromyalgia31.3SLC6A4, CRH
2arthritis30.6ADCYAP1, POMC, VIP
3serotonin syndrome30.5HTR1A, MAOA
4addison's disease30.5POMC, CRH
5seasonal affective disorder30.4HTR1A, SLC6A4, CRH
6anorexia nervosa30.3MAOA, CRH, IGFBP1, POMC, SLC6A4, HTR1A
7attention deficit hyperactivity disorder30.3MAOA, SLC6A4
8anxiety disorder30.0MAOA, SLC6A4, HTR1A, CRH
9irritable bowel syndrome30.0SLC6A4, CRH
10generalized anxiety disorder30.0HTR1A, SLC6A4
11persian gulf syndrome30.0VIP, ADCYAP1
12hepatitis c30.0RNASEL, EIF2AK2
13hypoglycemia30.0CRH, IGFBP1, POMC
14pulmonary disease, chronic obstructive29.8ADCYAP1, SLC6A4, NR3C1
15n syndrome11.0
16chronic pain10.7
17char syndrome10.6
18chronic orthostatic intolerance10.6
19orthostatic intolerance10.6
20myofascial pain syndrome10.5
21multiple chemical sensitivity10.5
22bronchiectasis10.4
23adult syndrome10.4
24postural orthostatic tachycardia syndrome10.4
25borna disease10.4
26infectious mononucleosis10.4
27micro syndrome10.3
28young syndrome10.3
29sleep disorder10.3
30autonomic dysfunction10.3
31dysautonomia10.3
32orchitis10.3
33meconium ileus10.3
34major depressive disorder10.2
35cystic fibrosis10.2
36sick building syndrome10.2
37chronic rhinitis10.2
38giardiasis10.2
39ehlers–danlos syndrome10.2
40short syndrome10.2
41macrophagic myofasciitis10.2
42immune-mediated encephalomyelitis10.2
43cftr-related disorders10.1
44ileus10.1
45lassa fever10.1
46arthropathy10.1
47cramp-fasciculation syndrome10.1
48sweat chloride elevation without cf10.1
49coronary artery disease,10.0
50chronic interstitial cystitis10.0

Graphical network of the top 20 diseases related to Chronic Fatigue Syndrome:



Diseases related to chronic fatigue syndrome

Clinical Features for Chronic Fatigue Syndrome

Drugs & Therapeutics for Chronic Fatigue Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Fatigue Syndrome

Drug clinical trials:

Search ClinicalTrials for Chronic Fatigue Syndrome

Search NIH Clinical Center for Chronic Fatigue Syndrome

Search CenterWatch for Chronic Fatigue Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Chronic Fatigue Syndrome

Anatomical Context for Chronic Fatigue Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Chronic Fatigue Syndrome:

33
Whole blood, Lymph node, Brain, Heart, Skeletal muscle, Small intestine, Skin, Prostate, Nk cells, T cells, B cells, Endothelial, Pituitary

Animal Models for Chronic Fatigue Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Chronic Fatigue Syndrome

Sources:
51PubMed
See all sources

Articles related to Chronic Fatigue Syndrome:

(show top 50)    (show all 678)
idTitleAuthorsYear
1
Attention processes in chronic fatigue syndrome: Attentional bias for health-related threat and the role of attentional control. (24262484)
2014
2
The epidemiology of chronic fatigue syndrome/myalgic encephalitis in children. (24146285)
2014
3
Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome. (23959519)
2013
4
Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome. (24182640)
2013
5
Examining the impact of obesity on individuals with chronic fatigue syndrome. (23799656)
2013
6
Discriminative validity of metabolic and workload measurements for identifying people with chronic fatigue syndrome. (23813081)
2013
7
The prevalence of chronic fatigue syndrome/ myalgic encephalomyelitis: a meta-analysis. (23576883)
2013
8
Psychological stress contributed to the development of low-grade fever in a patient with chronic fatigue syndrome: a case report. (23497734)
2013
9
Letter to the editor: response to correspondence concerning 'recovery from chronic fatigue syndrome after treatments in the PACE trial'. (23866117)
2013
10
Letter to the editor: 'recovery from chronic fatigue syndrome after treatments given in the PACE trial': data on the recovery groups as a whole would be useful. (23866114)
2013
11
Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome. (22932430)
2013
12
The Impact of Fatigue and Fibromyalgia on Sexual Dysfunction in Women with Chronic Fatigue Syndrome. (24274008)
2013
13
Prevalence, incidence, and classification of chronic fatigue syndrome in Olmsted County, Minnesota, as estimated using the Rochester Epidemiology Project. (23140977)
2012
14
Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome. (23166694)
2012
15
Therapist effects and the dissemination of cognitive behavior therapy for chronic fatigue syndrome in community-based mental health care. (22504122)
2012
16
Ultra-slow delta power in chronic fatigue syndrome. (22771174)
2012
17
Adolescent chronic fatigue syndrome; a follow-up study displays concurrent improvement of circulatory abnormalities and clinical symptoms. (22436201)
2012
18
Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. (22795611)
2012
19
Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. (22572093)
2012
20
Chronic Fatigue Syndrome (CFS) and Cancer Related Fatigue (CRF): two "fatigue" syndromes with overlapping symptoms and possibly related aetiologies. (23182646)
2012
21
Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. (20890710)
2011
22
Gynecological history in chronic fatigue syndrome: a population-based case-control study. (21091051)
2011
23
Chronic fatigue syndrome could be costing UK economy pound 100m a year, study says. (21930818)
2011
24
Amitriptyline and prochlorperazine inhibit proinflammatory mediator release from human mast cells: possible relevance to chronic fatigue syndrome. (21532369)
2011
25
Emotional expression, self-silencing, and distress tolerance in anorexia nervosa and chronic fatigue syndrome. (21810109)
2011
26
Listen to the story: chronic fatigue syndrome patients do not live in a vacuum. (21212717)
2011
27
Chronic fatigue syndrome in the media: a content analysis of newspaper articles. (21637403)
2011
28
Serotonin-selective reuptake inhibitors and nonsteroidal anti-inflammatory drugs--important considerations of adverse interactions especially for the treatment of myalgic encephalomyelitis/chronic fatigue syndrome. (21694612)
2011
29
Up-regulation of TGF-I^1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome. (22118314)
2011
30
Health-related quality of life in patients with chronic fatigue syndrome: group cognitive behavioural therapy and graded exercise versus usual treatment. A randomised controlled trial with 1A year of follow-up. (21234629)
2011
31
Metacognitions and negative emotions as predictors of symptom severity in chronic fatigue syndrome. (21414450)
2011
32
Researchers get 1.6m pound to look at scientific basis of chronic fatigue syndrome. (22188947)
2011
33
A case of chronic fatigue syndrome triggered by influenza H1N1 (swine influenza). (19858526)
2010
34
Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome. (20836869)
2010
35
Chronic fatigue syndrome poses management challenge. (21049784)
2010
36
High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome. (21092175)
2010
37
A controlled study of the effect of a mindfulness-based stress reduction technique in women with multiple chemical sensitivity, chronic fatigue syndrome, and fibromyalgia. (21197347)
2009
38
Combined dexamethasone/corticotropin-releasing factor test in chronic fatigue syndrome. (17803834)
2008
39
Chronic fatigue syndrome: exercise performance related to immune dysfunction. (16260962)
2005
40
Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. (11461161)
2001
41
Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors. (11288761)
2001
42
Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome. (10751014)
2000
43
A 37 kDa 2-5A binding protein as a potential biochemical marker for chronic fatigue syndrome. (11126321)
2000
44
Vitamin B status in patients with chronic fatigue syndrome. (10450194)
1999
45
Naloxone-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome. (9572086)
1998
46
High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome. (9041942)
1997
47
Changes in growth hormone, insulin, insulinlike growth factors (IGFs), and IGF-binding protein-1 in chronic fatigue syndrome. (9046989)
1997
48
Assessing somatization disorder in the chronic fatigue syndrome. (8677289)
1996
49
Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents. (8033924)
1994
50
Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome. (2064904)
1991

Genetic Variations for Chronic Fatigue Syndrome

Expression for genes affiliated with Chronic Fatigue Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Fatigue Syndrome

Search GEO for disease gene expression data for Chronic Fatigue Syndrome.

Pathways for genes affiliated with Chronic Fatigue Syndrome

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Compounds for genes affiliated with Chronic Fatigue Syndrome

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1testosterone45 60 11 2414.0POMC, IGFBP1, NR3C1, CRH, LBR, VIP
2norepinephrine45 11 2413.0IGFBP1, CRH, POMC, MAOA, SLC6A4, ADCYAP1
3corticosterone45 60 2413.0NR3C1, HTR1A, VIP, CRH, IGFBP1, POMC
45-hydroxytryptamine4511.0HTR1A, CRH, POMC, MAOA, SLC6A4, ADCYAP1
5epinephrine45 11 2413.0LBR, MAOA, SLC6A4, VIP, CRH, IGFBP1
6dopamine45 29 11 2414.0NR3C1, HTR2B, HTR1A, CRH, POMC, MAOA
7sertraline45 29 50 11 2414.9HTR1A, CRH, MAOA, SLC6A4, POMC
8fenfluramine29 45 1112.9SLC6A4, POMC, CRH, HTR2B, HTR1A
9acth4510.9CRH, ADCYAP1, POMC, IGFBP1, NR3C1, HTR1A
10clomipramine45 50 1112.9SLC6A4, HTR2B, HTR1A, CRH, MAOA
11gaba4510.9NR3C1, ADCYAP1, SLC6A4, MAOA, VIP, POMC
12desipramine45 50 1112.9HTR1A, CRH, NR3C1, MAOA, SLC6A4
13haloperidol45 29 2 50 1114.9VIP, HTR2B, ADCYAP1, HTR1A, POMC, SLC6A4
14sumatriptan45 29 60 50 11 2415.9VIP, HTR2B, HTR1A, MAOA, HTR5A
15arginine4510.9LBR, CRH, RNASEL, IGFBP1, POMC, SLC6A4
16fluoxetine50 45 29 1113.9MAOA, HTR1A, HTR2B, CRH, SLC6A4
17acetylcholine45 50 29 11 2414.9LBR, ADCYAP1, POMC, NR3C1, CRH, HTR1A
18mirtazapine50 45 1112.9SLC6A4, POMC, NR3C1, CRH
19methiothepin45 2911.9NR3C1, HTR1A, HTR2B, HTR5A
20metergoline45 2911.9NR3C1, HTR5A, HTR2B, HTR1A
21maoa4510.9MAOA, SLC6A4, HTR1A, POMC
22methysergide45 29 1112.9MAOA, HTR1A, HTR5A, HTR2B
23mianserin29 45 1112.9MAOA, HTR1A, SLC6A4, HTR2B
245-hydroxyindoleacetic acid45 2411.9VIP, CRH, MAOA, SLC6A4
25cycloheximide4510.9IGFBP1
26ketanserin29 4511.9SLC6A4, HTR1A, HTR2B, HTR5A
27mifepristone45 60 29 1113.9POMC, CRH, NR3C1, IGFBP1, LBR
28dexamethasone45 50 29 1113.9IGFBP1, POMC, NR3C1, MAOA, CRH, VIP
29clozapine45 29 50 1113.8POMC, HTR1A, HTR2B, HTR5A, SLC6A4
30catecholamine4510.8VIP, ADCYAP1, MAOA, POMC, CRH
31gnrh4510.8IGFBP1, ADCYAP1, VIP
32carbon-114510.8HTR1A, MAOA, SLC6A4
33p-chloroamphetamine4510.8SLC6A4, MAOA, HTR1A
34yohimbine45 29 2 1113.8HTR2B, CRH, HTR5A, HTR1A
35aspartate4510.8VIP, ADCYAP1, EIF2AK2, SLC6A4, POMC, NR3C1
36m-chlorophenylpiperazine4510.8HTR2B, SLC6A4, HTR1A
37naratriptan45 29 1112.8NR3C1, HTR1A, MAOA
38serine4510.8ADCYAP1, POMC, EIF2AK2, SLC6A4, VIP
39mcpp4510.7HTR2B, SLC6A4, HTR1A
40carbachol45 29 1112.7NR3C1, CRH, LBR, VIP, ADCYAP1
41ru 2496929 4511.7HTR1A, HTR5A, HTR2B
42dihydrotestosterone45 29 11 2413.7ADCYAP1, IGFBP1, NR3C1, VIP, SLC6A4
43bromocriptine29 45 1112.7POMC, VIP, HTR1A
44citalopram50 45 11 2413.6SLC6A4, MAOA, HTR1A
458-oh-dpat2910.6HTR1A, HTR5A, HTR2B
46astressin45 29 6012.6VIP, ADCYAP1, CRH
47mdma4510.5SLC6A4, MAOA, HTR1A
48minaprine45 1111.5HTR2B, MAOA, SLC6A4
495-ct2910.4HTR5A, HTR1A, HTR2B
50pindolol45 29 1112.2SLC6A4, HTR2B, HTR1A

GO Terms for genes affiliated with Chronic Fatigue Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5SLC6A4, P2RX5, CD300C, HTR5A, HTR1A, HTR2B
2extracellular regionGO:00557610.2ADCYAP1, VIP, CST7, CRH, IGFBP1, POMC

Biological processes related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.7HTR5A, HTR1A, HTR2B
2vasoconstrictionGO:04231010.7HTR2B, HTR1A, SLC6A4
3regulation of serotonin secretionGO:01406210.6CRH, HTR1A
4positive regulation of cell proliferationGO:00828410.6ADCYAP1, CRH, HTR2B, VIP, HTR1A
5positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5VIP, ADCYAP1
6signal transductionGO:00716510.5P2RX5, POMC, IGFBP1, NR3C1, CRH, TNFRSF17
7G-protein coupled receptor signaling pathwayGO:00718610.5HTR5A, HTR1A, HTR2B, VIP
8negative regulation of potassium ion transportGO:04326710.4ADCYAP1, VIP
9regulation of behaviorGO:05079510.2HTR1A, HTR2B

Molecular functions related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.5CRH, POMC, VIP
2neuropeptide hormone activityGO:00518410.5VIP, CRH, ADCYAP1
3serotonin receptor activityGO:00499310.4HTR5A, HTR1A, HTR2B
4lamin bindingGO:00552110.2SUN2, LBR

Products for genes affiliated with Chronic Fatigue Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Fatigue Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet