MCID: CHR066
MIFTS: 65

Chronic Fatigue Syndrome malady

Rare diseases, Neuronal diseases categories

Summaries for Chronic Fatigue Syndrome

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MedlinePlus:34 Chronic fatigue syndrome (cfs) is a disorder that causes extreme fatigue. this fatigue is not the kind of tired feeling that goes away after you rest. instead, it lasts a long time and limits your ability to do ordinary daily activities. the main symptom of cfs is severe fatigue that lasts for 6 months or more. you also have at least four of these other symptoms: feeling unwell for more than 24 hours after physical activity muscle pain memory problems headaches pain in multiple joints sleep problems sore throat tender lymph nodes cfs is hard to diagnose. there are no tests for it, and other illnesses can cause similar symptoms. your doctor has to rule out other diseases before making a diagnosis of cfs. no one knows what causes cfs. it is most common in women in their 40s and 50s, but anyone can have it. it can last for years. there is no cure for cfs, so the goal of treatment is to improve symptoms. medicine may treat pain, sleep disorders, and other problems. lifestyle changes, coping techniques, and a special, gradual exercise program can also help. centers for disease control and prevention

MalaCards based summary: Chronic Fatigue Syndrome, also known as postviral fatigue syndrome, is related to fibromyalgia and prostate cancer. An important gene associated with Chronic Fatigue Syndrome is RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Monoamine Transport. The drugs fish oils and coenzyme q10 and the compounds p-chloroamphetamine and carbon-11 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and prostate, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:10 A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.

NIH Rare Diseases:43 Chronic fatigue syndrome is a condition that causes extreme, long-lasting fatigue which can limit the ability to participate in ordinary, daily activities. it generally occurs in young adults between the ages of 20 and 40. the main symptom of this condition is disabling fatigue that does not improve with rest. other signs and symptoms may include muscle pain; joint pain; concentration and memory problems; headaches; sleep problems; fever; sore throat; and/or tender lymph nodes. the exact cause of chronic fatigue syndrome is not known, but it has been proposed that infectious agents, immune system impairment and/or hormonal system deregulation may be involved. there is no cure for this condition; the goal of treatment is to improve symptoms. medications may be used to treat pain, sleep disorders and other associated problems. last updated: 10/14/2013

CDC:4 Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms affect several body systems and may include weakness, muscle pain, impaired memory and/or mental concentration, and insomnia, which can result in reduced participation in daily activities.

Wikipedia:65 Chronic fatigue syndrome (CFS) is the common name for a group of debilitating medical conditions... more...

Aliases & Classifications for Chronic Fatigue Syndrome

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Chronic Fatigue Syndrome, Aliases & Descriptions:

Name: Chronic Fatigue Syndrome 10 43 12 45 34 4 62
Postviral Fatigue Syndrome 10 62
Myalgic Encephalomyelitis 10 43
 
Cfs 10 4
Encephalomyelitis, Myalgic 62
Myalgic Encephalitis 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Related Diseases for Chronic Fatigue Syndrome

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Diseases related to Chronic Fatigue Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1fibromyalgia31.4CRH, SLC6A4
2prostate cancer30.8IGFBP1, ADCYAP1, NR3C1, MAOA, RNASEL
3addison's disease30.6POMC, CRH
4personality disorder30.5MAOA, SLC6A4
5irritable bowel syndrome30.5CRH, SLC6A4
6rheumatoid arthritis30.5NR3C1, CRH, ADCYAP1, LBR
7attention deficit-hyperactivity disorder30.4SLC6A4, MAOA
8anxiety disorder30.3SLC6A4, CRH, MAOA, HTR1A
9migraine30.3MAOA, SLC6A4, ADCYAP1, HTR1A
10anorexia nervosa30.2SLC6A4, MAOA, IGFBP1, CRH, POMC, HTR1A
11generalized anxiety disorder30.2SLC6A4, HTR1A
12hypoglycemia30.1IGFBP1, CRH, POMC
13dementia30.1NR3C1, HTR1A, MAOA
14obesity30.0HTR1A, POMC, NR3C1, CRH, IGFBP1, MAOA
15schizophrenia30.0LBR, SLC6A4, NR3C1, ADCYAP1, HTR1A, MAOA
16pulmonary disease, chronic obstructive29.9SLC6A4, NR3C1, ADCYAP1
17leukemia10.7
18orthostatic intolerance10.6
19prostatitis10.6
20bronchiectasis10.6
21myofascial pain syndrome10.5
22multiple chemical sensitivity10.5
23blindness10.5
24arthritis10.5
25borna disease10.4
26cerebritis10.4
27postural orthostatic tachycardia syndrome10.4
28encephalitis10.4
29sleep disorder10.3
30dysautonomia10.3
31orchitis10.3
32meconium ileus10.3
33sick building syndrome10.2
34giardiasis10.2
35lyme disease10.2
36ehlers-danlos syndrome10.2
37influenza10.2
38rhinitis10.2
39macrophagic myofasciitis10.2
40autonomic dysfunction10.2
41chronic pain10.2
42esophageal cancer10.2
43infertility10.2
44esophagitis10.2
45pancreatitis10.2
46cftr-related disorders10.2
47ileus10.2
48lassa fever10.1
49arthropathy10.1
50kidney disease10.1

Graphical network of the top 20 diseases related to Chronic Fatigue Syndrome:



Diseases related to chronic fatigue syndrome

Symptoms for Chronic Fatigue Syndrome

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Drugs & Therapeutics for Chronic Fatigue Syndrome

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Drug clinical trials:

Search ClinicalTrials for Chronic Fatigue Syndrome

Search NIH Clinical Center for Chronic Fatigue Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Chronic Fatigue Syndrome

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Anatomical Context for Chronic Fatigue Syndrome

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MalaCards organs/tissues related to Chronic Fatigue Syndrome:

33
Lymph node, Testes, Prostate, Brain, Pituitary, Heart, Eye, Whole blood, Skeletal muscle, Skin, Neutrophil, T cells, B cells, Endothelial

Animal Models for Chronic Fatigue Syndrome or affiliated genes

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Publications for Chronic Fatigue Syndrome

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Articles related to Chronic Fatigue Syndrome:

(show top 50)    (show all 691)
idTitleAuthorsYear
1
Chronic fatigue syndrome: Features of a population of patients from northern Italy. (25816406)
2015
2
Treatment Outcome and Metacognitive Change in CBT and GET for Chronic Fatigue Syndrome. (25895437)
2015
3
Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. (25824300)
2015
4
Anti-neural antibody response in patients with post-treatment Lyme disease symptoms versus those with myalgic encephalomyelitis/chronic fatigue syndrome. (25866194)
2015
5
QR (Quercus Robur Extract, Robuvit) supplementation in subjects with chronic fatigue syndrome (CFS) and increased oxidative stress. A pilot registry. (25394351)
2014
6
Response to: reports of recovery in chronic fatigue syndrome may present less than meets the eye. (25239244)
2014
7
Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome. (25277740)
2014
8
Perfectionism and maladaptive coping styles in patients with chronic fatigue syndrome, irritable bowel syndrome and fibromyalgia/arthritis and in healthy controls. (25323951)
2014
9
Attention network test: Assessment of cognitive function in chronic fatigue syndrome. (24112872)
2013
10
Letter to the editor: comments on 'recovery from chronic fatigue syndrome after treatments given in the PACE trial'. (23866110)
2013
11
A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome. (22718491)
2013
12
Effects of qigong exercise on fatigue, anxiety, and depressive symptoms of patients with chronic fatigue syndrome-like illness: a randomized controlled trial. (23983785)
2013
13
Detection of mycotoxins in patients with chronic fatigue syndrome. (23580077)
2013
14
The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome. (23639303)
2013
15
Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial. (23967878)
2013
16
Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document. (22181560)
2012
17
Factors affecting duration of chronic fatigue syndrome in pediatric patients. (21617905)
2012
18
Comparison of chronic fatigue syndrome/myalgic encephalopathy with other disorders: an observational study. (22666529)
2012
19
Prevalence, incidence, and classification of chronic fatigue syndrome in Olmsted County, Minnesota, as estimated using the Rochester Epidemiology Project. (23140977)
2012
20
A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. (22431963)
2012
21
Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity. (21205027)
2011
22
Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. (20890710)
2011
23
Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data. (21584188)
2011
24
Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. (21334061)
2011
25
Finding the right balance of physical activity: a focus group study about experiences among patients with chronic fatigue syndrome. (20580520)
2011
26
Gynecological history in chronic fatigue syndrome: a population-based case-control study. (21091051)
2011
27
Immunologic and psychosocial status in chronic fatigue syndrome. (21585130)
2011
28
Self-investigation in adolescent chronic fatigue syndrome: narrative changes and health improvement. (20579832)
2011
29
The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome. (21600664)
2011
30
Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. (20550693)
2010
31
Biochemical and vascular aspects of pediatric chronic fatigue syndrome. (20819963)
2010
32
Possible detrimental effects of cognitive behaviour therapy for chronic fatigue syndrome. (20502065)
2010
33
Chronic fatigue syndrome is not caused by XMRV virus, study shows. (21177733)
2010
34
Criteria used to define chronic fatigue syndrome questioned. (20530190)
2010
35
Chronic fatigue syndrome and fibromyalgia: a status report in 2010. (21250522)
2010
36
Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: are they associated with age at onset and specific symptoms? (19758204)
2009
37
Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications. (18269338)
2008
38
Defining the occurrence and influence of alpha-delta sleep in chronic fatigue syndrome. (17301585)
2007
39
Orthostatic intolerance in chronic fatigue syndrome. (17349421)
2007
40
Erythrocyte oxidative damage in chronic fatigue syndrome. (17174731)
2007
41
Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635. (15691524)
2005
42
Chronic fatigue syndrome: exercise performance related to immune dysfunction. (16260962)
2005
43
Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism. (15554358)
2004
44
Dysautonomia in chronic fatigue syndrome: facts, hypotheses, implications. (14962627)
2004
45
Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. (11477286)
2001
46
Chronic Fatigue Syndrome (25905324)
2000
47
Vitamin B status in patients with chronic fatigue syndrome. (10450194)
1999
48
Structure and Determinants of Illness Representations in Chronic Disease: A Comparison of Addison's Disease and Chronic Fatigue Syndrome. (22021411)
1998
49
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome. (7893988)
1994
50
Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome. (1606197)
1992

Variations for Chronic Fatigue Syndrome

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Expression for genes affiliated with Chronic Fatigue Syndrome

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Search GEO for disease gene expression data for Chronic Fatigue Syndrome.

Pathways for genes affiliated with Chronic Fatigue Syndrome

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Pathways related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
2
Show member pathways
Serotonin Transporter Activity38
9.5MAOA, SLC6A4
39.3IGFBP1, NR3C1
49.2HTR1A, MAOA, SLC6A4
59.0CRH, ADCYAP1, POMC
6
Show member pathways
9.0POMC, ADCYAP1, CRH
7
Show member pathways
8.0NR3C1, CRH, ADCYAP1, POMC, HTR1A
87.7NR3C1, SLC6A4, MAOA, ADCYAP1, HTR1A

Compounds for genes affiliated with Chronic Fatigue Syndrome

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Compounds related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1p-chloroamphetamine459.6SLC6A4, MAOA, HTR1A
2carbon-11459.6HTR1A, MAOA, SLC6A4
35-hydroxytryptophan459.5HTR1A, CRH, SLC6A4
411 deoxycortisol459.5CRH, POMC, NR3C1
5mdma459.5MAOA, SLC6A4, HTR1A
6mhpg459.5CRH, SLC6A4, MAOA
7naratriptan45 30 1311.4NR3C1, MAOA, HTR1A
8betamethasone45 1310.4NR3C1, POMC, CRH
9homovanillic acid45 2610.4SLC6A4, CRH, MAOA
10mianserin45 30 1311.4SLC6A4, MAOA, HTR1A
11naltrexone45 30 51 1312.4LBR, POMC, CRH
12fenfluramine45 30 1311.3HTR1A, CRH, SLC6A4, POMC
13Serotonin269.3HTR1A, SLC6A4, MAOA
145-hydroxyindoleacetic acid45 2610.3MAOA, CRH, SLC6A4
15maoa459.3HTR1A, MAOA, SLC6A4, POMC
16fluvoxamine45 51 1311.2SLC6A4, MAOA, HTR1A
17clomipramine45 51 1311.2HTR1A, MAOA, SLC6A4, CRH
18fluoxetine45 51 30 1312.2MAOA, CRH, SLC6A4, HTR1A
19citalopram45 51 26 1312.2HTR1A, MAOA, CRH, SLC6A4
20metyrapone45 61 1311.2NR3C1, POMC, CRH
21mirtazapine45 51 1311.1SLC6A4, NR3C1, CRH, POMC
22ribonucleic acid459.0RNASEL, CRH, POMC, ADCYAP1
23opiate459.0SLC6A4, NR3C1, CRH, POMC
24dhea459.0POMC, CRH, NR3C1, IGFBP1
25sertraline45 30 51 26 1312.9HTR1A, MAOA, CRH, SLC6A4, POMC
26imipramine45 30 51 26 1312.9SLC6A4, MAOA, HTR1A, NR3C1
27cortisone45 269.9NR3C1, CRH, POMC
28hydrocortisone45 3 61 1311.9POMC, IGFBP1, NR3C1, CRH
29catecholamine458.8CRH, POMC, MAOA, ADCYAP1
30progestin458.8SLC6A4, NR3C1, POMC, IGFBP1
31haloperidol45 51 30 3 1312.7SLC6A4, HTR1A, ADCYAP1, POMC
32desipramine45 51 1310.6CRH, HTR1A, MAOA, NR3C1, SLC6A4
33mifepristone45 30 61 1311.6NR3C1, LBR, CRH, POMC, IGFBP1
34gnrh458.3POMC, IGFBP1, ADCYAP1, CRH, SLC6A4
35forskolin45 51 1310.2LBR, IGFBP1, POMC, ADCYAP1, CRH
365-hydroxytryptamine458.1SLC6A4, CRH, MAOA, HTR1A, ADCYAP1, POMC
37acetylcholine45 51 30 26 1311.9HTR1A, LBR, CRH, ADCYAP1, NR3C1, POMC
38acth457.9IGFBP1, HTR1A, ADCYAP1, CRH, NR3C1, POMC
39gaba457.9NR3C1, ADCYAP1, POMC, CRH, SLC6A4, MAOA
40progesterone45 30 61 26 1311.7LBR, CRH, ADCYAP1, POMC, NR3C1, IGFBP1
41steroid457.7POMC, ADCYAP1, IGFBP1, LBR, NR3C1, CRH
42arginine457.6RNASEL, POMC, IGFBP1, CRH, SLC6A4, LBR
43cycloheximide457.5CRH, POMC, NR3C1, ADCYAP1, RNASEL, IGFBP1
44epinephrine45 26 139.5MAOA, IGFBP1, ADCYAP1, POMC, SLC6A4, CRH
45dopamine45 30 26 1310.5MAOA, ADCYAP1, SLC6A4, HTR1A, NR3C1, CRH
46corticosterone45 61 269.4CRH, POMC, ADCYAP1, HTR1A, NR3C1, SLC6A4
47dexamethasone45 51 30 1310.4IGFBP1, LBR, POMC, ADCYAP1, CRH, NR3C1
48norepinephrine45 26 139.2CRH, MAOA, POMC, HTR1A, ADCYAP1, LBR
49serine456.8NR3C1, IGFBP1, SLC6A4, CRH, ADCYAP1, POMC
50testosterone45 61 26 139.6LBR, NR3C1, CRH, MAOA, ADCYAP1, SLC6A4

GO Terms for genes affiliated with Chronic Fatigue Syndrome

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Biological processes related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:00140629.8CRH, HTR1A
2vasoconstrictionGO:00423109.6SLC6A4, HTR1A
3adrenal gland developmentGO:00303259.4NR3C1, CRH
4behavioral fear responseGO:00016629.0ADCYAP1, HTR1A
5signal transductionGO:00071658.7POMC, IGFBP1, CRH, NR3C1

Molecular functions related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lamin bindingGO:00055219.6SUN2, LBR
2neuropeptide hormone activityGO:00051849.0CRH, ADCYAP1
3receptor bindingGO:00051029.0CRH, ADCYAP1, POMC

Products for genes affiliated with Chronic Fatigue Syndrome

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Sources for Chronic Fatigue Syndrome

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet