CFS
MCID: CHR066
MIFTS: 66

Chronic Fatigue Syndrome (CFS) malady

Rare diseases, Neuronal diseases categories
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Summaries for Chronic Fatigue Syndrome

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MedlinePlus:33 Chronic fatigue syndrome (cfs) is a disorder that causes extreme fatigue. this fatigue is not the kind of tired feeling that goes away after you rest. instead, it lasts a long time and limits your ability to do ordinary daily activities. the main symptom of cfs is severe fatigue that lasts for 6 months or more. you also have at least four of these other symptoms: feeling unwell for more than 24 hours after physical activity muscle pain memory problems headaches pain in multiple joints sleep problems sore throat tender lymph nodes cfs is hard to diagnose. there are no tests for it, and other illnesses can cause similar symptoms. your doctor has to rule out other diseases before making a diagnosis of cfs. no one knows what causes cfs. it is most common in women in their 40s and 50s, but anyone can have it. it can last for years. there is no cure for cfs, so the goal of treatment is to improve symptoms. medicine may treat pain, sleep disorders, and other problems. lifestyle changes, coping techniques, and a special, gradual exercise program can also help. centers for disease control and prevention

MalaCards based summary: Chronic Fatigue Syndrome, also known as postviral fatigue syndrome, is related to fibromyalgia and addison's disease. An important gene associated with Chronic Fatigue Syndrome is RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Monoamine Transport. The drugs fish oils and coenzyme q10 and the compounds p-chloroamphetamine and carbon-11 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and prostate, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:8 A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.

NIH Rare Diseases:42 Chronic fatigue syndrome is a condition that causes extreme, long-lasting fatigue which can limit the ability to participate in ordinary, daily activities. it generally occurs in young adults between the ages of 20 and 40. the main symptom of this condition is disabling fatigue that does not improve with rest. other signs and symptoms may include muscle pain; joint pain; concentration and memory problems; headaches; sleep problems; fever; sore throat; and/or tender lymph nodes. the exact cause of chronic fatigue syndrome is not known, but it has been proposed that infectious agents, immune system impairment and/or hormonal system deregulation may be involved. there is no cure for this condition; the goal of treatment is to improve symptoms. medications may be used to treat pain, sleep disorders and other associated problems. last updated: 10/14/2013

CDC:3 Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms affect several body systems and may include weakness, muscle pain, impaired memory and/or mental concentration, and insomnia, which can result in reduced participation in daily activities.

Wikipedia:65 Chronic fatigue syndrome (CFS) is the common name for a group of significantly debilitating medical... more...

Aliases & Classifications for Chronic Fatigue Syndrome

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Chronic Fatigue Syndrome, Aliases & Descriptions:

Name: Chronic Fatigue Syndrome 8 42 10 44 33 62
Postviral Fatigue Syndrome 8 62
Myalgic Encephalomyelitis 8 42
 
Encephalomyelitis, Myalgic 62
Myalgic Encephalitis 8
Cfs 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Related Diseases for Chronic Fatigue Syndrome

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Diseases related to Chronic Fatigue Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1fibromyalgia31.7CRH, SLC6A4
2addison's disease31.0CRH, POMC
3personality disorder30.7MAOA, SLC6A4
4seasonal affective disorder30.7HTR1A, CRH, SLC6A4
5irritable bowel syndrome30.7CRH, SLC6A4
6attention deficit hyperactivity disorder30.6MAOA, SLC6A4
7generalized anxiety disorder30.5SLC6A4, HTR1A
8multiple sclerosis30.2ADCYAP1, POMC, LBR
9dementia30.1HTR1A, MAOA, NR3C1
10prostate cancer30.1IGFBP1, RNASEL, ADCYAP1, MAOA, NR3C1
11anxiety disorder30.1SLC6A4, CRH, MAOA, HTR1A
12rheumatoid arthritis30.0NR3C1, CRH, ADCYAP1, LBR
13migraine30.0ADCYAP1, HTR1A, MAOA, SLC6A4
14anorexia nervosa29.7IGFBP1, POMC, HTR1A, MAOA, CRH, SLC6A4
15chronic obstructive pulmonary disease29.6ADCYAP1, NR3C1, SLC6A4
16obesity29.4IGFBP1, POMC, HTR1A, MAOA, CRH, NR3C1
17schizophrenia29.0LBR, ADCYAP1, HTR1A, MAOA, NR3C1, SLC6A4
18leukemia10.7
19prostatitis10.6
20orthostatic intolerance10.6
21bronchiectasis10.5
22myofascial pain syndrome10.5
23multiple chemical sensitivity10.5
24blindness10.5
25adrenal carcinoma10.5POMC
26pituitary carcinoma10.5POMC
27reynolds syndrome10.5LBR
28neuroleptic malignant syndrome10.5HTR1A
29arthritis10.5
30borna disease10.4
31infectious mononucleosis10.4
32cerebritis10.4
33postural orthostatic tachycardia syndrome10.4
34sheehan syndrome10.4POMC, CRH
35gonadal disease10.4POMC, CRH
36encephalitis10.4
37hypoadrenalism10.4POMC, CRH
38infantile epileptic encephalopathy10.4POMC, CRH
39pituitary gland disease10.4POMC, CRH
40amnestic disorder10.4POMC, HTR1A
41acth deficiency10.3POMC, CRH
42serotonin syndrome10.3MAOA, HTR1A
43amenorrhea10.3CRH, POMC
44adrenal adenoma10.3POMC, CRH
45hyperprolactinemia10.3CRH, POMC
46sleep disorder10.3
47dysautonomia10.3
48agoraphobia10.3HTR1A, MAOA
49hypopituitarism10.3CRH, POMC
50orchitis10.3

Graphical network of the top 20 diseases related to Chronic Fatigue Syndrome:



Diseases related to chronic fatigue syndrome

Symptoms for Chronic Fatigue Syndrome

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Drugs & Therapeutics for Chronic Fatigue Syndrome

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Drug clinical trials:

Search ClinicalTrials for Chronic Fatigue Syndrome

Search NIH Clinical Center for Chronic Fatigue Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Chronic Fatigue Syndrome

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Anatomical Context for Chronic Fatigue Syndrome

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MalaCards organs/tissues related to Chronic Fatigue Syndrome:

32
Lymph node, Testes, Prostate, Brain, Pituitary, Heart, Eye, Whole blood, Skin, Neutrophil, Skeletal muscle, T cells, B cells, Endothelial

Animal Models for Chronic Fatigue Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Chronic Fatigue Syndrome:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3LBR, POMC, ADCYAP1, NR3C1
2MP:00107718.2SLC6A4, NR3C1, CRH, POMC, LBR
3MP:00053797.9LBR, POMC, CRH, NR3C1, SLC6A4
4MP:00053977.7LBR, POMC, RNASEL, ADCYAP1, CRH, NR3C1
5MP:00053877.3LBR, IGFBP1, POMC, RNASEL, ADCYAP1, CRH
6MP:00053847.3LBR, IGFBP1, POMC, RNASEL, ADCYAP1, CRH
7MP:00053787.2LBR, SUN2, POMC, ADCYAP1, CRH, NR3C1
8MP:00107687.0LBR, SUN2, POMC, ADCYAP1, HTR1A, NR3C1
9MP:00053866.8LBR, POMC, ADCYAP1, HTR1A, MAOA, CRH
10MP:00036316.8LBR, POMC, ADCYAP1, HTR1A, MAOA, CRH
11MP:00053766.5SLC6A4, LBR, SUN2, POMC, ADCYAP1, HTR1A

Publications for Chronic Fatigue Syndrome

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Articles related to Chronic Fatigue Syndrome:

(show top 50)    (show all 672)
idTitleAuthorsYear
1
QR (Quercus Robur Extract, Robuvit) supplementation in subjects with chronic fatigue syndrome (CFS) and increased oxidative stress. A pilot registry. (25394351)
2014
2
Response to: reports of recovery in chronic fatigue syndrome may present less than meets the eye. (25239244)
2014
3
Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome. (25277740)
2014
4
Perfectionism and maladaptive coping styles in patients with chronic fatigue syndrome, irritable bowel syndrome and fibromyalgia/arthritis and in healthy controls. (25323951)
2014
5
Attention network test: Assessment of cognitive function in chronic fatigue syndrome. (24112872)
2013
6
Letter to the editor: comments on 'recovery from chronic fatigue syndrome after treatments given in the PACE trial'. (23866110)
2013
7
A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome. (22718491)
2013
8
Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome. (23959519)
2013
9
Effects of qigong exercise on fatigue, anxiety, and depressive symptoms of patients with chronic fatigue syndrome-like illness: a randomized controlled trial. (23983785)
2013
10
Detection of mycotoxins in patients with chronic fatigue syndrome. (23580077)
2013
11
The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome. (23639303)
2013
12
Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial. (23967878)
2013
13
Understanding medical students' views of Chronic Fatigue Syndrome: A qualitative study. (24058124)
2013
14
Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document. (22181560)
2012
15
Factors affecting duration of chronic fatigue syndrome in pediatric patients. (21617905)
2012
16
Comparison of chronic fatigue syndrome/myalgic encephalopathy with other disorders: an observational study. (22666529)
2012
17
Prevalence, incidence, and classification of chronic fatigue syndrome in Olmsted County, Minnesota, as estimated using the Rochester Epidemiology Project. (23140977)
2012
18
A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. (22431963)
2012
19
Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity. (21205027)
2011
20
Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. (20890710)
2011
21
Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data. (21584188)
2011
22
Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. (21334061)
2011
23
Finding the right balance of physical activity: a focus group study about experiences among patients with chronic fatigue syndrome. (20580520)
2011
24
Gynecological history in chronic fatigue syndrome: a population-based case-control study. (21091051)
2011
25
Immunologic and psychosocial status in chronic fatigue syndrome. (21585130)
2011
26
Self-investigation in adolescent chronic fatigue syndrome: narrative changes and health improvement. (20579832)
2011
27
The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome. (21600664)
2011
28
Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. (20550693)
2010
29
Biochemical and vascular aspects of pediatric chronic fatigue syndrome. (20819963)
2010
30
Possible detrimental effects of cognitive behaviour therapy for chronic fatigue syndrome. (20502065)
2010
31
Chronic fatigue syndrome is not caused by XMRV virus, study shows. (21177733)
2010
32
Criteria used to define chronic fatigue syndrome questioned. (20530190)
2010
33
Chronic fatigue syndrome and fibromyalgia: a status report in 2010. (21250522)
2010
34
Sleep stage transitions in chronic fatigue syndrome patients with or without fibromyalgia. (21096267)
2010
35
Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: are they associated with age at onset and specific symptoms? (19758204)
2009
36
Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications. (18269338)
2008
37
Defining the occurrence and influence of alpha-delta sleep in chronic fatigue syndrome. (17301585)
2007
38
Orthostatic intolerance in chronic fatigue syndrome. (17349421)
2007
39
Erythrocyte oxidative damage in chronic fatigue syndrome. (17174731)
2007
40
Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635. (15691524)
2005
41
Chronic fatigue syndrome: exercise performance related to immune dysfunction. (16260962)
2005
42
Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism. (15554358)
2004
43
Dysautonomia in chronic fatigue syndrome: facts, hypotheses, implications. (14962627)
2004
44
Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. (11477286)
2001
45
IgE levels are the same in chronic fatigue syndrome (CFS) and control subjects when stratified by allergy skin test results and rhinitis types. (11570618)
2001
46
Vitamin B status in patients with chronic fatigue syndrome. (10450194)
1999
47
Structure and Determinants of Illness Representations in Chronic Disease: A Comparison of Addison's Disease and Chronic Fatigue Syndrome. (22021411)
1998
48
Fibromyalgia, chronic fatigue syndrome, and myofascial pain. (9567202)
1998
49
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome. (7893988)
1994
50
Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome. (1606197)
1992

Variations for Chronic Fatigue Syndrome

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Expression for genes affiliated with Chronic Fatigue Syndrome

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Expression patterns in normal tissues for genes affiliated with Chronic Fatigue Syndrome

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Pathways for genes affiliated with Chronic Fatigue Syndrome

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Pathways related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
2
Show member pathways
Serotonin Transporter Activity37
9.5SLC6A4, MAOA
39.3NR3C1, IGFBP1
49.2HTR1A, MAOA, SLC6A4
59.0CRH, ADCYAP1, POMC
6
Show member pathways
9.0POMC, ADCYAP1, CRH
7
Show member pathways
8.0POMC, ADCYAP1, HTR1A, CRH, NR3C1
87.7SLC6A4, NR3C1, MAOA, HTR1A, ADCYAP1

Compounds for genes affiliated with Chronic Fatigue Syndrome

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Compounds related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1p-chloroamphetamine449.6SLC6A4, MAOA, HTR1A
2carbon-11449.6HTR1A, MAOA, SLC6A4
35-hydroxytryptophan449.5HTR1A, CRH, SLC6A4
411 deoxycortisol449.5CRH, POMC, NR3C1
5mdma449.5MAOA, SLC6A4, HTR1A
6mhpg449.5CRH, SLC6A4, MAOA
7naratriptan44 28 1111.4NR3C1, MAOA, HTR1A
8betamethasone44 1110.4NR3C1, POMC, CRH
9homovanillic acid44 2410.4SLC6A4, CRH, MAOA
10mianserin44 28 1111.4SLC6A4, MAOA, HTR1A
11naltrexone44 28 50 1112.4LBR, POMC, CRH
12fenfluramine44 28 1111.3HTR1A, CRH, SLC6A4, POMC
13Serotonin249.3HTR1A, SLC6A4, MAOA
145-hydroxyindoleacetic acid44 2410.3MAOA, CRH, SLC6A4
15maoa449.3HTR1A, MAOA, SLC6A4, POMC
16fluvoxamine44 50 1111.2SLC6A4, MAOA, HTR1A
17clomipramine44 50 1111.2HTR1A, MAOA, SLC6A4, CRH
18fluoxetine44 50 28 1112.2MAOA, CRH, SLC6A4, HTR1A
19citalopram44 50 24 1112.2HTR1A, MAOA, CRH, SLC6A4
20metyrapone44 61 1111.2NR3C1, POMC, CRH
21mirtazapine44 50 1111.1SLC6A4, NR3C1, CRH, POMC
22ribonucleic acid449.0RNASEL, CRH, POMC, ADCYAP1
23opiate449.0SLC6A4, NR3C1, CRH, POMC
24dhea449.0POMC, CRH, NR3C1, IGFBP1
25sertraline44 28 50 24 1112.9HTR1A, MAOA, CRH, SLC6A4, POMC
26imipramine44 28 50 24 1112.9SLC6A4, MAOA, HTR1A, NR3C1
27cortisone44 249.9NR3C1, CRH, POMC
28hydrocortisone44 2 61 1111.9POMC, IGFBP1, NR3C1, CRH
29catecholamine448.8CRH, POMC, MAOA, ADCYAP1
30progestin448.8SLC6A4, NR3C1, POMC, IGFBP1
31haloperidol44 50 28 2 1112.7SLC6A4, HTR1A, ADCYAP1, POMC
32desipramine44 50 1110.6CRH, HTR1A, MAOA, NR3C1, SLC6A4
33mifepristone44 28 61 1111.6NR3C1, LBR, CRH, POMC, IGFBP1
34gnrh448.3POMC, IGFBP1, ADCYAP1, CRH, SLC6A4
35forskolin44 50 1110.2LBR, IGFBP1, POMC, ADCYAP1, CRH
365-hydroxytryptamine448.1SLC6A4, CRH, MAOA, HTR1A, ADCYAP1, POMC
37acetylcholine44 50 28 24 1111.9HTR1A, LBR, CRH, ADCYAP1, NR3C1, POMC
38acth447.9IGFBP1, HTR1A, ADCYAP1, CRH, NR3C1, POMC
39gaba447.9NR3C1, ADCYAP1, POMC, CRH, SLC6A4, MAOA
40progesterone44 28 61 24 1111.7LBR, CRH, ADCYAP1, POMC, NR3C1, IGFBP1
41steroid447.7POMC, ADCYAP1, IGFBP1, LBR, NR3C1, CRH
42arginine447.6RNASEL, POMC, IGFBP1, CRH, SLC6A4, LBR
43cycloheximide447.5CRH, POMC, NR3C1, ADCYAP1, RNASEL, IGFBP1
44epinephrine44 24 119.5MAOA, IGFBP1, ADCYAP1, POMC, SLC6A4, CRH
45dopamine44 28 24 1110.5MAOA, ADCYAP1, SLC6A4, HTR1A, NR3C1, CRH
46corticosterone44 61 249.4CRH, POMC, ADCYAP1, HTR1A, NR3C1, SLC6A4
47dexamethasone44 50 28 1110.4IGFBP1, LBR, POMC, ADCYAP1, CRH, NR3C1
48norepinephrine44 24 119.2CRH, MAOA, POMC, HTR1A, ADCYAP1, LBR
49serine446.8NR3C1, IGFBP1, SLC6A4, CRH, ADCYAP1, POMC
50testosterone44 61 24 119.6LBR, NR3C1, CRH, MAOA, ADCYAP1, SLC6A4

GO Terms for genes affiliated with Chronic Fatigue Syndrome

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Biological processes related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:0140629.8CRH, HTR1A
2vasoconstrictionGO:0423109.6SLC6A4, HTR1A
3adrenal gland developmentGO:0303259.4NR3C1, CRH
4behavioral fear responseGO:0016629.0ADCYAP1, HTR1A
5signal transductionGO:0071658.7NR3C1, CRH, POMC, IGFBP1

Molecular functions related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lamin bindingGO:0055219.6SUN2, LBR
2neuropeptide hormone activityGO:0051849.0CRH, ADCYAP1
3receptor bindingGO:0051029.0CRH, ADCYAP1, POMC

Products for genes affiliated with Chronic Fatigue Syndrome

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Sources for Chronic Fatigue Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet