CFS
MCID: CHR066
MIFTS: 65

Chronic Fatigue Syndrome (CFS) malady

Neuronal diseases category

Summaries for Chronic Fatigue Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Chronic fatigue syndrome (cfs) is a disorder that causes extreme fatigue. this fatigue is not the kind of tired feeling that goes away after you rest. instead, it lasts a long time and limits your ability to do ordinary daily activities. the main symptom of cfs is severe fatigue that lasts for 6 months or more. you also have at least four of these other symptoms: feeling unwell for more than 24 hours after physical activity muscle pain memory problems headaches pain in multiple joints sleep problems sore throat tender lymph nodes cfs is hard to diagnose. there are no tests for it, and other illnesses can cause similar symptoms. your doctor has to rule out other diseases before making a diagnosis of cfs. no one knows what causes cfs. it is most common in women in their 40s and 50s, but anyone can have it. it can last for years. there is no cure for cfs, so the goal of treatment is to improve symptoms. medicine may treat pain, sleep disorders, and other problems. lifestyle changes, coping techniques, and a special, gradual exercise program can also help. centers for disease control and prevention

MalaCards: Chronic Fatigue Syndrome, also known as myalgic encephalomyelitis, is related to leukemia and arthritis. An important gene associated with Chronic Fatigue Syndrome is RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and SIDS Susceptibility Pathways. The drugs fish oils and coenzyme q10 and the compounds testosterone and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and prostate, and related mouse phenotypes are immune system and behavior/neurological.

Disease Ontology:8 A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to extertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.

NIH Rare Diseases:42 Chronic fatigue syndrome is a condition that causes extreme, long-lasting fatigue which can limit the ability to participate in ordinary, daily activities. it generally occurs in young adults between the ages of 20 and 40. the main symptom of this condition is disabling fatigue that does not improve with rest. other signs and symptoms may include muscle pain; joint pain; concentration and memory problems; headaches; sleep problems; fever; sore throat; and/or tender lymph nodes. the exact cause of chronic fatigue syndrome is not known, but it has been proposed that infectious agents, immune system impairment and/or hormonal system deregulation may be involved. there is no cure for this condition; the goal of treatment is to improve symptoms. medications may be used to treat pain, sleep disorders and other associated problems. last updated: 10/14/2013

CDC:3 Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms affect several body systems and may include weakness, muscle pain, impaired memory and/or mental concentration, and insomnia, which can result in reduced participation in daily activities.

Wikipedia:63 Chronic fatigue syndrome (CFS) is the common name for a group of significantly debilitating medical... more...

Aliases & Classifications for Chronic Fatigue Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

chronic fatigue syndrome 8 42 10 44 33 60
myalgic encephalomyelitis 8 42
postviral fatigue syndrome 8
myalgic encephalitis 8
cfs 8


Related Diseases for Chronic Fatigue Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chronic Fatigue Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0EIF2AK2, RNASEL, IGFBP1, NR3C1, LBR
2arthritis30.5ADCYAP1, POMC, VIP
3rheumatoid arthritis30.5ADCYAP1, NR3C1, CRH, LBR, TNFRSF17, VIP
4addison's disease30.5POMC, CRH
5seasonal affective disorder30.4HTR1A, CRH, SLC6A4
6anorexia nervosa30.2HTR1A, CRH, IGFBP1, POMC, MAOA, SLC6A4
7multiple sclerosis30.2ADCYAP1, EIF2AK2, POMC, LBR, TNFRSF17
8migraine30.2ADCYAP1, SLC6A4, MAOA, HTR1A, HTR2B, VIP
9attention deficit hyperactivity disorder30.2SLC6A4, MAOA
10personality disorder30.2MAOA, SLC6A4
11obesity30.0MAOA, POMC, IGFBP1, NR3C1, CRH, HTR1A
12dementia30.0MAOA, NR3C1, HTR1A
13anxiety disorder30.0HTR1A, CRH, MAOA, SLC6A4
14hepatitis30.0IGFBP1
15ischemia30.0ADCYAP1, HTR1A, VIP
16schizophrenia30.0HTR1A, LBR, NR3C1, MAOA, SLC6A4, ADCYAP1
17irritable bowel syndrome30.0SLC6A4, CRH
18generalized anxiety disorder30.0HTR1A, SLC6A4
19persian gulf syndrome30.0VIP, ADCYAP1
20hypoglycemia30.0POMC, IGFBP1, CRH
21encephalomyelitis10.9
22prostate cancer10.5
23prostatitis10.5
24myofascial pain syndrome10.5
25multiple chemical sensitivity10.5
26bronchiectasis10.4
27adult syndrome10.4
28borna disease10.4
29infectious mononucleosis10.4
30cerebritis10.3
31encephalitis10.3
32arts syndrome10.3
33sleep disorder10.3
34image syndrome10.3
35orchitis10.2
36major depressive disorder10.2
37cystic fibrosis10.2
38sick building syndrome10.2
39chronic rhinitis10.2
40giardiasis10.2
41ehlers-danlos syndrome10.2
42influenza10.2
43rhinitis10.2
44infertility10.1
45esophageal cancer10.1
46esophagitis10.1
47pancreatitis10.1
48cftr-related disorders10.1
49lassa fever10.0
50arthropathy10.0

Graphical network of the top 20 diseases related to Chronic Fatigue Syndrome:



Diseases related to chronic fatigue syndrome

Clinical Features for Chronic Fatigue Syndrome

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Drugs & Therapeutics for Chronic Fatigue Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Fatigue Syndrome

Drug clinical trials:

Search ClinicalTrials for Chronic Fatigue Syndrome

Search NIH Clinical Center for Chronic Fatigue Syndrome

Search CenterWatch for Chronic Fatigue Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Chronic Fatigue Syndrome

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Anatomical Context for Chronic Fatigue Syndrome

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32MalaCards
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MalaCards organs/tissues related to Chronic Fatigue Syndrome:

32
Lymph node, Testes, Prostate, Pituitary, Brain, Heart, Whole blood, Skin, Skeletal muscle, B cells, Endothelial, Eye, T cells

Animal Models for Chronic Fatigue Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chronic Fatigue Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6ADCYAP1, VIP, TNFRSF17, LBR, CRH, NR3C1
2MP:000538610.6LBR, HTR5A, HTR1A, VIP, CRH, NR3C1
3MP:000537610.5HTR1A, LBR, CRH, NR3C1, POMC, MAOA
4MP:000287310.5VIP, CST7, TNFRSF17, HTR2B, HTR5A, CRH
5MP:000539710.4TNFRSF17, LBR, CRH, NR3C1, POMC, RNASEL
6MP:001076810.2VIP, HTR2B, HTR1A, LBR, NR3C1, POMC

Publications for Chronic Fatigue Syndrome

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Sources:
50PubMed
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Articles related to Chronic Fatigue Syndrome:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome. (23952563)
2014
2
Effects of qigong exercise on fatigue, anxiety, and depressive symptoms of patients with chronic fatigue syndrome-like illness: a randomized controlled trial. (23983785)
2013
3
Neuromuscular strain as a contributor to cognitive and other symptoms in chronic fatigue syndrome: hypothesis and conceptual model. (23720638)
2013
4
The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome. (23963977)
2013
5
Letter to the editor: 'recovery from chronic fatigue syndrome after treatments given in the PACE trial': an appropriate threshold for a recovery? (23866113)
2013
6
Allostatic overload in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (23850395)
2013
7
'Sometimes it feels as if the world goes on without me': adolescents' experiences of living with chronic fatigue syndrome. (24354631)
2013
8
Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology. (23570606)
2013
9
Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document. (22181560)
2012
10
A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM). (23032646)
2012
11
Coping styles in chronic fatigue syndrome: findings from a population-based study. (22301698)
2012
12
Response to valganciclovir in chronic fatigue syndrome patients with human herpesvirus 6 and Epstein-Barr virus IgG antibody titers. (23080504)
2012
13
Can persistent Epstein-Barr virus infection induce chronic fatigue syndrome as a Pavlov reflex of the immune response? (22873615)
2012
14
Chronic fatigue syndrome, the immune system and viral infection. (21756995)
2012
15
Family-focused cognitive behaviour therapy versus psycho-education for adolescents with chronic fatigue syndrome: long-term follow-up of an RCT. (22985998)
2012
16
Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor. (23240035)
2012
17
Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome. (23061432)
2012
18
Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running. (21884774)
2012
19
Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study. (21911849)
2012
20
Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis. (22583968)
2012
21
Chronic fatigue syndrome: a qualitative investigation of young patient's beliefs and coping strategies. (21473686)
2011
22
Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome. (21543496)
2011
23
Chronic fatigue syndrome. (21615974)
2011
24
What stops children with a chronic illness accessing health care: a mixed methods study in children with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). (22078101)
2011
25
Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome. (21294212)
2011
26
Dietary salt restriction and chronic fatigue syndrome: a hypothesis. (21680102)
2011
27
Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature. (21576403)
2011
28
Paper linking XMRV to chronic fatigue syndrome stirs controversy. (21905071)
2011
29
Biochemical and vascular aspects of pediatric chronic fatigue syndrome. (20819963)
2010
30
Use of adaptol in the treatment of chronic fatigue syndrome in patients with chronic cerebral ischemia. (20635214)
2010
31
Nitric oxide concentrations are normal and unrelated to activity level in chronic fatigue syndrome: a case-control study. (21164046)
2010
32
Nitric oxide metabolite production during exercise in chronic fatigue syndrome: a case-control study. (20469961)
2010
33
Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome. (20676841)
2010
34
Effectiveness of stepped care for chronic fatigue syndrome: a randomized noninferiority trial. (20873907)
2010
35
Gut inflammation in chronic fatigue syndrome. (20939923)
2010
36
Chronic fatigue syndrome/myalgic encephalomyelitis: an update. (21244747)
2010
37
Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate. (20629967)
2010
38
Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. (20008700)
2009
39
Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications. (18269338)
2008
40
Lower frequency of IL-17F sequence variant (His161Arg) in chronic fatigue syndrome patients. (18774769)
2008
41
Orthostatic intolerance in chronic fatigue syndrome. (17349421)
2007
42
Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome. (16610957)
2006
43
Dysautonomia in chronic fatigue syndrome: facts, hypotheses, implications. (14962627)
2004
44
Say NO to fibromyalgia and chronic fatigue syndrome: an alternative and complementary therapy to aerobic exercise. (15193362)
2004
45
Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome. (12851722)
2003
46
Chronic fatigue syndrome: a form of Addison's disease. (10886497)
2000
47
Borna disease virus infection in two family clusters of patients with chronic fatigue syndrome. (10529109)
1999
48
Similarity of symptoms in chronic fatigue syndrome and Addison's disease. (9466137)
1997
49
Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome. (9243369)
1997
50
Increased prolactin response to buspirone in chronic fatigue syndrome. (8938208)
1996

Genetic Variations for Chronic Fatigue Syndrome

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Expression for genes affiliated with Chronic Fatigue Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Fatigue Syndrome

Search GEO for disease gene expression data for Chronic Fatigue Syndrome.

Pathways for genes affiliated with Chronic Fatigue Syndrome

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Chronic Fatigue Syndrome

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2414.0POMC, IGFBP1, NR3C1, CRH, LBR, VIP
2norepinephrine44 11 2413.0IGFBP1, CRH, POMC, MAOA, SLC6A4, ADCYAP1
3corticosterone44 59 2413.0NR3C1, HTR1A, VIP, CRH, IGFBP1, POMC
45-hydroxytryptamine4411.0HTR1A, CRH, POMC, MAOA, SLC6A4, ADCYAP1
5epinephrine44 11 2413.0LBR, MAOA, SLC6A4, VIP, CRH, IGFBP1
6dopamine44 28 11 2414.0NR3C1, HTR2B, HTR1A, CRH, POMC, MAOA
7sertraline44 28 49 11 2414.9HTR1A, CRH, MAOA, SLC6A4, POMC
8fenfluramine28 44 1112.9SLC6A4, POMC, CRH, HTR2B, HTR1A
9acth4410.9CRH, ADCYAP1, POMC, IGFBP1, NR3C1, HTR1A
10clomipramine44 49 1112.9SLC6A4, HTR2B, HTR1A, CRH, MAOA
11gaba4410.9NR3C1, ADCYAP1, SLC6A4, MAOA, VIP, POMC
12desipramine44 49 1112.9HTR1A, CRH, NR3C1, MAOA, SLC6A4
13haloperidol44 28 2 49 1114.9VIP, HTR2B, ADCYAP1, HTR1A, POMC, SLC6A4
14sumatriptan44 28 59 49 11 2415.9VIP, HTR2B, HTR1A, MAOA, HTR5A
15arginine4410.9LBR, CRH, RNASEL, IGFBP1, POMC, SLC6A4
16fluoxetine49 44 28 1113.9MAOA, HTR1A, HTR2B, CRH, SLC6A4
17acetylcholine44 49 28 11 2414.9LBR, ADCYAP1, POMC, NR3C1, CRH, HTR1A
18mirtazapine49 44 1112.9SLC6A4, POMC, NR3C1, CRH
19methiothepin44 2811.9NR3C1, HTR1A, HTR2B, HTR5A
20metergoline44 2811.9NR3C1, HTR5A, HTR2B, HTR1A
21maoa4410.9MAOA, SLC6A4, HTR1A, POMC
22methysergide44 28 1112.9MAOA, HTR1A, HTR5A, HTR2B
23mianserin28 44 1112.9MAOA, HTR1A, SLC6A4, HTR2B
245-hydroxyindoleacetic acid44 2411.9VIP, CRH, MAOA, SLC6A4
25cycloheximide4410.9IGFBP1
26ketanserin28 4411.9SLC6A4, HTR1A, HTR2B, HTR5A
27mifepristone44 59 28 1113.9POMC, CRH, NR3C1, IGFBP1, LBR
28dexamethasone44 49 28 1113.9IGFBP1, POMC, NR3C1, MAOA, CRH, VIP
29clozapine44 28 49 1113.8POMC, HTR1A, HTR2B, HTR5A, SLC6A4
30catecholamine4410.8VIP, ADCYAP1, MAOA, POMC, CRH
31gnrh4410.8IGFBP1, ADCYAP1, VIP
32carbon-114410.8HTR1A, MAOA, SLC6A4
33p-chloroamphetamine4410.8SLC6A4, MAOA, HTR1A
34yohimbine44 28 2 1113.8HTR2B, CRH, HTR5A, HTR1A
35aspartate4410.8VIP, ADCYAP1, EIF2AK2, SLC6A4, POMC, NR3C1
36m-chlorophenylpiperazine4410.8HTR2B, SLC6A4, HTR1A
37naratriptan44 28 1112.8NR3C1, HTR1A, MAOA
38serine4410.8ADCYAP1, POMC, EIF2AK2, SLC6A4, VIP
39mcpp4410.7HTR2B, SLC6A4, HTR1A
40carbachol44 28 1112.7NR3C1, CRH, LBR, VIP, ADCYAP1
41ru 2496928 4411.7HTR1A, HTR5A, HTR2B
42dihydrotestosterone44 28 11 2413.7ADCYAP1, IGFBP1, NR3C1, VIP, SLC6A4
43bromocriptine28 44 1112.7POMC, VIP, HTR1A
44citalopram49 44 11 2413.6SLC6A4, MAOA, HTR1A
458-oh-dpat2810.6HTR1A, HTR5A, HTR2B
46astressin44 28 5912.6VIP, ADCYAP1, CRH
47mdma4410.5SLC6A4, MAOA, HTR1A
48minaprine44 1111.5HTR2B, MAOA, SLC6A4
495-ct2810.4HTR5A, HTR1A, HTR2B
50pindolol44 28 1112.2SLC6A4, HTR2B, HTR1A

GO Terms for genes affiliated with Chronic Fatigue Syndrome

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16Gene Ontology
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Cellular components related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5SLC6A4, P2RX5, CD300C, HTR5A, HTR1A, HTR2B
2extracellular regionGO:00557610.2ADCYAP1, VIP, CST7, CRH, IGFBP1, POMC

Biological processes related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.7HTR5A, HTR1A, HTR2B
2vasoconstrictionGO:04231010.7SLC6A4, HTR1A, HTR2B
3regulation of serotonin secretionGO:01406210.6HTR1A, CRH
4positive regulation of cell proliferationGO:00828410.6ADCYAP1, CRH, HTR1A, HTR2B, VIP
5positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5VIP, ADCYAP1
6signal transductionGO:00716510.5P2RX5, POMC, IGFBP1, NR3C1, CRH, TNFRSF17
7G-protein coupled receptor signaling pathwayGO:00718610.5HTR5A, HTR1A, HTR2B, VIP
8regulation of behaviorGO:05079510.4HTR2B, HTR1A
9negative regulation of potassium ion transportGO:04326710.2VIP, ADCYAP1

Molecular functions related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.5POMC, CRH, VIP
2neuropeptide hormone activityGO:00518410.5ADCYAP1, CRH, VIP
3serotonin receptor activityGO:00499310.4HTR2B, HTR1A, HTR5A
4lamin bindingGO:00552110.2SUN2, LBR

Products for genes affiliated with Chronic Fatigue Syndrome

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  • Antibodies
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Sources for Chronic Fatigue Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet