CFS
MCID: CHR066
MIFTS: 64

Chronic Fatigue Syndrome (CFS) malady

Rare diseases, Neuronal diseases categories
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Summaries for Chronic Fatigue Syndrome

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Chronic fatigue syndrome (cfs) is a disorder that causes extreme fatigue. this fatigue is not the kind of tired feeling that goes away after you rest. instead, it lasts a long time and limits your ability to do ordinary daily activities. the main symptom of cfs is severe fatigue that lasts for 6 months or more. you also have at least four of these other symptoms: feeling unwell for more than 24 hours after physical activity muscle pain memory problems headaches pain in multiple joints sleep problems sore throat tender lymph nodes cfs is hard to diagnose. there are no tests for it, and other illnesses can cause similar symptoms. your doctor has to rule out other diseases before making a diagnosis of cfs. no one knows what causes cfs. it is most common in women in their 40s and 50s, but anyone can have it. it can last for years. there is no cure for cfs, so the goal of treatment is to improve symptoms. medicine may treat pain, sleep disorders, and other problems. lifestyle changes, coping techniques, and a special, gradual exercise program can also help. centers for disease control and prevention

MalaCards: Chronic Fatigue Syndrome, also known as myalgic encephalomyelitis, is related to fibromyalgia and prostate cancer. An important gene associated with Chronic Fatigue Syndrome is RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Monoamine Transport. The drugs fish oils and venlafaxine and the compounds p-chloroamphetamine and carbon-11 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and prostate, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:8 A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to extertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.

NIH Rare Diseases:43 Chronic fatigue syndrome is a condition that causes extreme, long-lasting fatigue which can limit the ability to participate in ordinary, daily activities. it generally occurs in young adults between the ages of 20 and 40. the main symptom of this condition is disabling fatigue that does not improve with rest. other signs and symptoms may include muscle pain; joint pain; concentration and memory problems; headaches; sleep problems; fever; sore throat; and/or tender lymph nodes. the exact cause of chronic fatigue syndrome is not known, but it has been proposed that infectious agents, immune system impairment and/or hormonal system deregulation may be involved. there is no cure for this condition; the goal of treatment is to improve symptoms. medications may be used to treat pain, sleep disorders and other associated problems. last updated: 10/14/2013

CDC:4 Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms affect several body systems and may include weakness, muscle pain, impaired memory and/or mental concentration, and insomnia, which can result in reduced participation in daily activities.

Wikipedia:65 Chronic fatigue syndrome (CFS) is the common name for a group of significantly debilitating medical... more...

Aliases & Classifications for Chronic Fatigue Syndrome

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

chronic fatigue syndrome 8 43 10 45 34 62
myalgic encephalomyelitis 8 43
postviral fatigue syndrome 8
myalgic encephalitis 8
cfs 8


Related Diseases for Chronic Fatigue Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chronic Fatigue Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1fibromyalgia31.4CRH, SLC6A4
2prostate cancer30.7IGFBP1, RNASEL, ADCYAP1, MAOA, NR3C1
3addison's disease30.6CRH, POMC
4seasonal affective disorder30.5HTR1A, CRH, SLC6A4
5rheumatoid arthritis30.4NR3C1, CRH, ADCYAP1, LBR
6personality disorder30.4MAOA, SLC6A4
7attention deficit hyperactivity disorder30.4MAOA, SLC6A4
8multiple sclerosis30.3ADCYAP1, POMC, LBR
9migraine30.2ADCYAP1, HTR1A, MAOA, SLC6A4
10generalized anxiety disorder30.2SLC6A4, HTR1A
11anorexia nervosa30.2IGFBP1, POMC, HTR1A, MAOA, CRH, SLC6A4
12irritable bowel syndrome30.2CRH, SLC6A4
13hypoglycemia30.1CRH, POMC, IGFBP1
14dementia30.1HTR1A, MAOA, NR3C1
15anxiety disorder30.1SLC6A4, CRH, MAOA, HTR1A
16schizophrenia29.8LBR, ADCYAP1, HTR1A, MAOA, NR3C1, SLC6A4
17encephalomyelitis11.0
18leukemia10.7
19prostatitis10.6
20orthostatic intolerance10.6
21multiple chemical sensitivity10.5
22blindness10.5
23myofascial pain syndrome10.5
24paine syndrome10.5
25bronchiectasis10.5
26borna disease10.4
27infectious mononucleosis10.4
28arthritis10.4
29postural orthostatic tachycardia syndrome10.4
30cerebritis10.4
31encephalitis10.4
32sleep disorder10.3
33dysautonomia10.3
34orchitis10.3
35meconium ileus10.3
36sick building syndrome10.2
37cystic fibrosis10.2
38major depressive disorder10.2
39giardiasis10.2
40ehlers-danlos syndrome10.2
41influenza10.2
42rhinitis10.2
43macrophagic myofasciitis10.2
44autonomic dysfunction10.2
45chronic pain10.2
46infertility10.2
47esophageal cancer10.2
48esophagitis10.2
49pancreatitis10.2
50cftr-related disorders10.2

Graphical network of the top 20 diseases related to Chronic Fatigue Syndrome:



Diseases related to chronic fatigue syndrome

Symptoms for Chronic Fatigue Syndrome

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Drugs & Therapeutics for Chronic Fatigue Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Chronic Fatigue Syndrome

Search NIH Clinical Center for Chronic Fatigue Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Chronic Fatigue Syndrome

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Anatomical Context for Chronic Fatigue Syndrome

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33MalaCards
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MalaCards organs/tissues related to Chronic Fatigue Syndrome:

33
Lymph node, Testes, Prostate, Pituitary, Heart, Brain, Whole blood, Eye, Skeletal muscle, T cells, B cells, Endothelial, Skin

Animal Models for Chronic Fatigue Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Chronic Fatigue Syndrome:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3LBR, POMC, ADCYAP1, NR3C1
2MP:00107718.2SLC6A4, NR3C1, CRH, POMC, LBR
3MP:00053797.9LBR, POMC, CRH, NR3C1, SLC6A4
4MP:00053977.7LBR, POMC, RNASEL, ADCYAP1, CRH, NR3C1
5MP:00053877.3LBR, IGFBP1, POMC, RNASEL, ADCYAP1, CRH
6MP:00053847.3LBR, IGFBP1, POMC, RNASEL, ADCYAP1, CRH
7MP:00053787.2LBR, SUN2, POMC, ADCYAP1, CRH, NR3C1
8MP:00107687.0LBR, SUN2, POMC, ADCYAP1, HTR1A, NR3C1
9MP:00053866.8LBR, POMC, ADCYAP1, HTR1A, MAOA, CRH
10MP:00036316.8LBR, POMC, ADCYAP1, HTR1A, MAOA, CRH
11MP:00053766.5SLC6A4, LBR, SUN2, POMC, ADCYAP1, HTR1A

Publications for Chronic Fatigue Syndrome

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Sources:
52PubMed
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Articles related to Chronic Fatigue Syndrome:

(show top 50)    (show all 651)
idTitleAuthorsYear
1
Attention network test: Assessment of cognitive function in chronic fatigue syndrome. (24112872)
2013
2
Letter to the editor: comments on 'recovery from chronic fatigue syndrome after treatments given in the PACE trial'. (23866110)
2013
3
A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome. (22718491)
2013
4
Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome. (23959519)
2013
5
Effects of qigong exercise on fatigue, anxiety, and depressive symptoms of patients with chronic fatigue syndrome-like illness: a randomized controlled trial. (23983785)
2013
6
Detection of mycotoxins in patients with chronic fatigue syndrome. (23580077)
2013
7
The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome. (23639303)
2013
8
Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial. (23967878)
2013
9
Understanding medical students' views of Chronic Fatigue Syndrome: A qualitative study. (24058124)
2013
10
Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome. (24182640)
2013
11
Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document. (22181560)
2012
12
Factors affecting duration of chronic fatigue syndrome in pediatric patients. (21617905)
2012
13
Comparison of chronic fatigue syndrome/myalgic encephalopathy with other disorders: an observational study. (22666529)
2012
14
Prevalence, incidence, and classification of chronic fatigue syndrome in Olmsted County, Minnesota, as estimated using the Rochester Epidemiology Project. (23140977)
2012
15
A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. (22431963)
2012
16
Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity. (21205027)
2011
17
Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. (20890710)
2011
18
Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data. (21584188)
2011
19
Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. (21334061)
2011
20
Finding the right balance of physical activity: a focus group study about experiences among patients with chronic fatigue syndrome. (20580520)
2011
21
Gynecological history in chronic fatigue syndrome: a population-based case-control study. (21091051)
2011
22
Immunologic and psychosocial status in chronic fatigue syndrome. (21585130)
2011
23
Self-investigation in adolescent chronic fatigue syndrome: narrative changes and health improvement. (20579832)
2011
24
The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome. (21600664)
2011
25
Chronic fatigue syndrome: where to PACE from here? (21334060)
2011
26
Role of infection and neurologic dysfunction in chronic fatigue syndrome. (21964849)
2011
27
Psychopathology and physical activity as predictors of chronic fatigue syndrome in the 1958 british birth cohort: a replication study of the 1946 and 1970 birth cohorts. (21458727)
2011
28
Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. (20550693)
2010
29
Biochemical and vascular aspects of pediatric chronic fatigue syndrome. (20819963)
2010
30
Possible detrimental effects of cognitive behaviour therapy for chronic fatigue syndrome. (20502065)
2010
31
Chronic fatigue syndrome is not caused by XMRV virus, study shows. (21177733)
2010
32
Criteria used to define chronic fatigue syndrome questioned. (20530190)
2010
33
Chronic fatigue syndrome and fibromyalgia: a status report in 2010. (21250522)
2010
34
Sleep stage transitions in chronic fatigue syndrome patients with or without fibromyalgia. (21096267)
2010
35
A case of chronic fatigue syndrome triggered by influenza H1N1 (swine influenza). (19858526)
2010
36
Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: are they associated with age at onset and specific symptoms? (19758204)
2009
37
Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications. (18269338)
2008
38
Defining the occurrence and influence of alpha-delta sleep in chronic fatigue syndrome. (17301585)
2007
39
Orthostatic intolerance in chronic fatigue syndrome. (17349421)
2007
40
Erythrocyte oxidative damage in chronic fatigue syndrome. (17174731)
2007
41
Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635. (15691524)
2005
42
Chronic fatigue syndrome: exercise performance related to immune dysfunction. (16260962)
2005
43
Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism. (15554358)
2004
44
Dysautonomia in chronic fatigue syndrome: facts, hypotheses, implications. (14962627)
2004
45
Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. (11477286)
2001
46
IgE levels are the same in chronic fatigue syndrome (CFS) and control subjects when stratified by allergy skin test results and rhinitis types. (11570618)
2001
47
Vitamin B status in patients with chronic fatigue syndrome. (10450194)
1999
48
Structure and Determinants of Illness Representations in Chronic Disease: A Comparison of Addison's Disease and Chronic Fatigue Syndrome. (22021411)
1998
49
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome. (7893988)
1994
50
Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome. (1606197)
1992

Variations for Chronic Fatigue Syndrome

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Expression for genes affiliated with Chronic Fatigue Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Fatigue Syndrome

Search GEO for disease gene expression data for Chronic Fatigue Syndrome.

Pathways for genes affiliated with Chronic Fatigue Syndrome

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Sources:
50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 53QIAGEN, 30KEGG
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Pathways related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
2
Show member pathways
Serotonin Transporter Activity38
9.5SLC6A4, MAOA
39.3NR3C1, IGFBP1
49.2HTR1A, MAOA, SLC6A4
59.0CRH, ADCYAP1, POMC
6
Show member pathways
9.0POMC, ADCYAP1, CRH
7
Show member pathways
8.0POMC, ADCYAP1, HTR1A, CRH, NR3C1
87.7SLC6A4, NR3C1, MAOA, HTR1A, ADCYAP1

Compounds for genes affiliated with Chronic Fatigue Syndrome

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1p-chloroamphetamine459.6SLC6A4, MAOA, HTR1A
2carbon-11459.6HTR1A, MAOA, SLC6A4
35-hydroxytryptophan459.5HTR1A, CRH, SLC6A4
411 deoxycortisol459.5CRH, POMC, NR3C1
5mdma459.5MAOA, SLC6A4, HTR1A
6mhpg459.5CRH, SLC6A4, MAOA
7naratriptan45 29 1111.4NR3C1, MAOA, HTR1A
8betamethasone45 1110.4NR3C1, POMC, CRH
9homovanillic acid45 2410.4SLC6A4, CRH, MAOA
10mianserin45 29 1111.4SLC6A4, MAOA, HTR1A
11naltrexone45 29 51 1112.4LBR, POMC, CRH
12fenfluramine45 29 1111.3HTR1A, CRH, SLC6A4, POMC
13Serotonin249.3HTR1A, SLC6A4, MAOA
145-hydroxyindoleacetic acid45 2410.3MAOA, CRH, SLC6A4
15maoa459.3HTR1A, MAOA, SLC6A4, POMC
16fluvoxamine45 51 1111.2SLC6A4, MAOA, HTR1A
17clomipramine45 51 1111.2HTR1A, MAOA, SLC6A4, CRH
18fluoxetine45 51 29 1112.2MAOA, CRH, SLC6A4, HTR1A
19citalopram45 51 24 1112.2HTR1A, MAOA, CRH, SLC6A4
20metyrapone45 61 1111.2NR3C1, POMC, CRH
21mirtazapine45 51 1111.1SLC6A4, NR3C1, CRH, POMC
22ribonucleic acid459.0RNASEL, CRH, POMC, ADCYAP1
23opiate459.0SLC6A4, NR3C1, CRH, POMC
24dhea459.0POMC, CRH, NR3C1, IGFBP1
25sertraline45 29 51 24 1112.9HTR1A, MAOA, CRH, SLC6A4, POMC
26imipramine45 29 51 24 1112.9SLC6A4, MAOA, HTR1A, NR3C1
27cortisone45 249.9NR3C1, CRH, POMC
28hydrocortisone45 3 61 1111.9POMC, IGFBP1, NR3C1, CRH
29catecholamine458.8CRH, POMC, MAOA, ADCYAP1
30progestin458.8SLC6A4, NR3C1, POMC, IGFBP1
31haloperidol45 51 29 3 1112.7SLC6A4, HTR1A, ADCYAP1, POMC
32desipramine45 51 1110.6CRH, HTR1A, MAOA, NR3C1, SLC6A4
33mifepristone45 29 61 1111.6NR3C1, LBR, CRH, POMC, IGFBP1
34gnrh458.3POMC, IGFBP1, ADCYAP1, CRH, SLC6A4
35forskolin45 51 1110.2LBR, IGFBP1, POMC, ADCYAP1, CRH
365-hydroxytryptamine458.1SLC6A4, CRH, MAOA, HTR1A, ADCYAP1, POMC
37acetylcholine45 51 29 24 1111.9HTR1A, LBR, CRH, ADCYAP1, NR3C1, POMC
38acth457.9IGFBP1, HTR1A, ADCYAP1, CRH, NR3C1, POMC
39gaba457.9NR3C1, ADCYAP1, POMC, CRH, SLC6A4, MAOA
40progesterone45 29 61 24 1111.7LBR, CRH, ADCYAP1, POMC, NR3C1, IGFBP1
41steroid457.7POMC, ADCYAP1, IGFBP1, LBR, NR3C1, CRH
42arginine457.6RNASEL, POMC, IGFBP1, CRH, SLC6A4, LBR
43cycloheximide457.5CRH, POMC, NR3C1, ADCYAP1, RNASEL, IGFBP1
44epinephrine45 24 119.5MAOA, IGFBP1, ADCYAP1, POMC, SLC6A4, CRH
45dopamine45 29 24 1110.5MAOA, ADCYAP1, SLC6A4, HTR1A, NR3C1, CRH
46corticosterone45 61 249.4CRH, POMC, ADCYAP1, HTR1A, NR3C1, SLC6A4
47dexamethasone45 51 29 1110.4IGFBP1, LBR, POMC, ADCYAP1, CRH, NR3C1
48norepinephrine45 24 119.2CRH, MAOA, POMC, HTR1A, ADCYAP1, LBR
49serine456.8NR3C1, IGFBP1, SLC6A4, CRH, ADCYAP1, POMC
50testosterone45 61 24 119.6LBR, NR3C1, CRH, MAOA, ADCYAP1, SLC6A4

GO Terms for genes affiliated with Chronic Fatigue Syndrome

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16Gene Ontology
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Biological processes related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:0140629.8CRH, HTR1A
2vasoconstrictionGO:0423109.6SLC6A4, HTR1A
3adrenal gland developmentGO:0303259.4NR3C1, CRH
4behavioral fear responseGO:0016629.0ADCYAP1, HTR1A
5signal transductionGO:0071658.7NR3C1, CRH, POMC, IGFBP1

Molecular functions related to Chronic Fatigue Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lamin bindingGO:0055219.6SUN2, LBR
2neuropeptide hormone activityGO:0051849.0CRH, ADCYAP1
3receptor bindingGO:0051029.0CRH, ADCYAP1, POMC

Products for genes affiliated with Chronic Fatigue Syndrome

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  • Antibodies
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Sources for Chronic Fatigue Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet