MCID: CHR066
MIFTS: 55

Chronic Fatigue Syndrome malady

Rare diseases, Neuronal diseases categories

Summaries for Chronic Fatigue Syndrome

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MedlinePlus:32 Chronic fatigue syndrome (cfs) is a disorder that causes extreme fatigue. this fatigue is not the kind of tired feeling that goes away after you rest. instead, it lasts a long time and limits your ability to do ordinary daily activities. the main symptom of cfs is severe fatigue that lasts for 6 months or more. you also have at least four of these other symptoms: feeling unwell for more than 24 hours after physical activity muscle pain memory problems headaches pain in multiple joints sleep problems sore throat tender lymph nodes cfs is hard to diagnose. there are no tests for it, and other illnesses can cause similar symptoms. your doctor has to rule out other diseases before making a diagnosis of cfs. no one knows what causes cfs. it is most common in women in their 40s and 50s, but anyone can have it. it can last for years. there is no cure for cfs, so the goal of treatment is to improve symptoms. medicine may treat pain, sleep disorders, and other problems. lifestyle changes, coping techniques, and a special, gradual exercise program can also help. centers for disease control and prevention

MalaCards based summary: Chronic Fatigue Syndrome, also known as myalgic encephalomyelitis, is related to fibromyalgia and addison's disease. An important gene associated with Chronic Fatigue Syndrome is RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Monoamine Transport. The drugs fish oils and coenzyme q10 and the compounds p-chloroamphetamine and carbon-11 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and prostate, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:9 A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.

NIH Rare Diseases:41 Chronic fatigue syndrome is a condition that causes extreme, long-lasting fatigue which can limit the ability to participate in ordinary, daily activities. it generally occurs in young adults between the ages of 20 and 40. the main symptom of this condition is disabling fatigue that does not improve with rest. other signs and symptoms may include muscle pain; joint pain; concentration and memory problems; headaches; sleep problems; fever; sore throat; and/or tender lymph nodes. the exact cause of chronic fatigue syndrome is not known, but it has been proposed that infectious agents, immune system impairment and/or hormonal system deregulation may be involved. there is no cure for this condition; the goal of treatment is to improve symptoms. medications may be used to treat pain, sleep disorders and other associated problems. last updated: 10/14/2013

CDC:3 Chronic fatigue syndrome, or CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Symptoms affect several body systems and may include weakness, muscle pain, impaired memory and/or mental concentration, and insomnia, which can result in reduced participation in daily activities.

Wikipedia:63 Chronic fatigue syndrome (CFS) is the common name for a group of debilitating medical conditions... more...

Aliases & Classifications for Chronic Fatigue Syndrome

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Chronic Fatigue Syndrome, Aliases & Descriptions:

Name: Chronic Fatigue Syndrome 9 41 11 43 32 3 60
Myalgic Encephalomyelitis 9 41
Cfs 9 3
 
Postviral Fatigue Syndrome 9
Myalgic Encephalitis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Related Diseases for Chronic Fatigue Syndrome

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Diseases related to Chronic Fatigue Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1fibromyalgia31.8CRH, SLC6A4
2addison's disease31.0POMC, CRH
3personality disorder30.8MAOA, SLC6A4
4irritable bowel syndrome30.8CRH, SLC6A4
5attention deficit-hyperactivity disorder30.6SLC6A4, MAOA
6generalized anxiety disorder30.5SLC6A4, HTR1A
7hypoglycemia30.3IGFBP1, CRH, POMC
8anxiety disorder30.3SLC6A4, CRH, MAOA, HTR1A
9dementia30.1NR3C1, HTR1A, MAOA
10prostate cancer30.1IGFBP1, ADCYAP1, NR3C1, MAOA, RNASEL
11rheumatoid arthritis30.0NR3C1, CRH, ADCYAP1, LBR
12migraine30.0MAOA, SLC6A4, ADCYAP1, HTR1A
13anorexia nervosa29.7SLC6A4, MAOA, IGFBP1, CRH, POMC, HTR1A
14pulmonary disease, chronic obstructive29.6SLC6A4, NR3C1, ADCYAP1
15obesity29.4HTR1A, POMC, NR3C1, CRH, IGFBP1, MAOA
16schizophrenia29.0LBR, SLC6A4, NR3C1, ADCYAP1, HTR1A, MAOA
17leukemia10.7
18orthostatic intolerance10.6
19prostatitis10.6
20bronchiectasis10.6
21myofascial pain syndrome10.5
22multiple chemical sensitivity10.5
23blindness10.5
24adrenal carcinoma10.5POMC
25pituitary carcinoma10.5POMC
26reynolds syndrome10.5LBR
27arthritis10.5
28neuroleptic malignant syndrome10.5HTR1A
29borna disease10.4
30cerebritis10.4
31postural orthostatic tachycardia syndrome10.4
32sheehan syndrome10.4CRH, POMC
33encephalitis10.4
34gonadal disease10.4CRH, POMC
35hypoadrenalism10.4CRH, POMC
36west syndrome10.4POMC, CRH
37pituitary gland disease10.4POMC, CRH
38amnestic disorder10.3POMC, HTR1A
39acth deficiency10.3POMC, CRH
40serotonin syndrome10.3MAOA, HTR1A
41amenorrhea10.3POMC, CRH
42adrenal adenoma10.3POMC, CRH
43hyperprolactinemia10.3CRH, POMC
44sleep disorder10.3
45dysautonomia10.3
46orchitis10.3
47agoraphobia10.3MAOA, HTR1A
48hypopituitarism10.3POMC, CRH
49substance abuse10.3CRH, SLC6A4
50meconium ileus10.3

Graphical network of the top 20 diseases related to Chronic Fatigue Syndrome:



Diseases related to chronic fatigue syndrome

Symptoms for Chronic Fatigue Syndrome

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Drugs & Therapeutics for Chronic Fatigue Syndrome

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Drug clinical trials:

Search ClinicalTrials for Chronic Fatigue Syndrome

Search NIH Clinical Center for Chronic Fatigue Syndrome

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Chronic Fatigue Syndrome

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Anatomical Context for Chronic Fatigue Syndrome

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MalaCards organs/tissues related to Chronic Fatigue Syndrome:

31
Lymph node, Testes, Prostate, Brain, Pituitary, Heart, Eye, Whole blood, Skeletal muscle, Skin, Neutrophil, T cells, B cells, Endothelial

Animal Models for Chronic Fatigue Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Chronic Fatigue Syndrome:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.3LBR, POMC, ADCYAP1, NR3C1
2MP:00107718.2SLC6A4, NR3C1, CRH, POMC, LBR
3MP:00053797.9LBR, POMC, CRH, NR3C1, SLC6A4
4MP:00053977.7LBR, POMC, RNASEL, ADCYAP1, CRH, NR3C1
5MP:00053877.3LBR, IGFBP1, POMC, RNASEL, ADCYAP1, CRH
6MP:00053847.3LBR, IGFBP1, POMC, RNASEL, ADCYAP1, CRH
7MP:00053787.2LBR, SUN2, POMC, ADCYAP1, CRH, NR3C1
8MP:00107687.0LBR, SUN2, POMC, ADCYAP1, HTR1A, NR3C1
9MP:00053866.8LBR, POMC, ADCYAP1, HTR1A, MAOA, CRH
10MP:00036316.8LBR, POMC, ADCYAP1, HTR1A, MAOA, CRH
11MP:00053766.5SLC6A4, LBR, SUN2, POMC, ADCYAP1, HTR1A

Publications for Chronic Fatigue Syndrome

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Articles related to Chronic Fatigue Syndrome:

(show top 50)    (show all 691)
idTitleAuthorsYear
1
Chronic fatigue syndrome: Features of a population of patients from northern Italy. (25816406)
2015
2
Treatment Outcome and Metacognitive Change in CBT and GET for Chronic Fatigue Syndrome. (25895437)
2015
3
Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. (25824300)
2015
4
Anti-neural antibody response in patients with post-treatment Lyme disease symptoms versus those with myalgic encephalomyelitis/chronic fatigue syndrome. (25866194)
2015
5
QR (Quercus Robur Extract, Robuvit) supplementation in subjects with chronic fatigue syndrome (CFS) and increased oxidative stress. A pilot registry. (25394351)
2014
6
Response to: reports of recovery in chronic fatigue syndrome may present less than meets the eye. (25239244)
2014
7
Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome. (25277740)
2014
8
Perfectionism and maladaptive coping styles in patients with chronic fatigue syndrome, irritable bowel syndrome and fibromyalgia/arthritis and in healthy controls. (25323951)
2014
9
Attention network test: Assessment of cognitive function in chronic fatigue syndrome. (24112872)
2013
10
Letter to the editor: comments on 'recovery from chronic fatigue syndrome after treatments given in the PACE trial'. (23866110)
2013
11
A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome. (22718491)
2013
12
Effects of qigong exercise on fatigue, anxiety, and depressive symptoms of patients with chronic fatigue syndrome-like illness: a randomized controlled trial. (23983785)
2013
13
Detection of mycotoxins in patients with chronic fatigue syndrome. (23580077)
2013
14
The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome. (23639303)
2013
15
Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial. (23967878)
2013
16
Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document. (22181560)
2012
17
Factors affecting duration of chronic fatigue syndrome in pediatric patients. (21617905)
2012
18
Comparison of chronic fatigue syndrome/myalgic encephalopathy with other disorders: an observational study. (22666529)
2012
19
Prevalence, incidence, and classification of chronic fatigue syndrome in Olmsted County, Minnesota, as estimated using the Rochester Epidemiology Project. (23140977)
2012
20
A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. (22431963)
2012
21
Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity. (21205027)
2011
22
Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. (20890710)
2011
23
Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data. (21584188)
2011
24
Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. (21334061)
2011
25
Finding the right balance of physical activity: a focus group study about experiences among patients with chronic fatigue syndrome. (20580520)
2011
26
Gynecological history in chronic fatigue syndrome: a population-based case-control study. (21091051)
2011
27
Immunologic and psychosocial status in chronic fatigue syndrome. (21585130)
2011
28
Self-investigation in adolescent chronic fatigue syndrome: narrative changes and health improvement. (20579832)
2011
29
The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome. (21600664)
2011
30
Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. (20550693)
2010
31
Biochemical and vascular aspects of pediatric chronic fatigue syndrome. (20819963)
2010
32
Possible detrimental effects of cognitive behaviour therapy for chronic fatigue syndrome. (20502065)
2010
33
Chronic fatigue syndrome is not caused by XMRV virus, study shows. (21177733)
2010
34
Criteria used to define chronic fatigue syndrome questioned. (20530190)
2010
35
Chronic fatigue syndrome and fibromyalgia: a status report in 2010. (21250522)
2010
36
Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: are they associated with age at onset and specific symptoms? (19758204)
2009
37
Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications. (18269338)
2008
38
Defining the occurrence and influence of alpha-delta sleep in chronic fatigue syndrome. (17301585)
2007
39
Orthostatic intolerance in chronic fatigue syndrome. (17349421)
2007
40
Erythrocyte oxidative damage in chronic fatigue syndrome. (17174731)
2007
41
Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635. (15691524)
2005
42
Chronic fatigue syndrome: exercise performance related to immune dysfunction. (16260962)
2005
43
Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism. (15554358)
2004
44
Dysautonomia in chronic fatigue syndrome: facts, hypotheses, implications. (14962627)
2004
45
Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. (11477286)
2001
46
Chronic Fatigue Syndrome (25905324)
2000
47
Vitamin B status in patients with chronic fatigue syndrome. (10450194)
1999
48
Structure and Determinants of Illness Representations in Chronic Disease: A Comparison of Addison's Disease and Chronic Fatigue Syndrome. (22021411)
1998
49
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome. (7893988)
1994
50
Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome. (1606197)
1992

Variations for Chronic Fatigue Syndrome

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Expression for genes affiliated with Chronic Fatigue Syndrome

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Search GEO for disease gene expression data for Chronic Fatigue Syndrome.

Pathways for genes affiliated with Chronic Fatigue Syndrome

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Pathways related to Chronic Fatigue Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRH, POMC
2
Show member pathways
Serotonin Transporter Activity36
9.5SLC6A4, MAOA
39.3NR3C1, IGFBP1
49.2HTR1A, MAOA, SLC6A4
59.0CRH, ADCYAP1, POMC
6
Show member pathways
9.0POMC, ADCYAP1, CRH
7
Show member pathways
8.0POMC, ADCYAP1, HTR1A, CRH, NR3C1
87.7SLC6A4, NR3C1, MAOA, HTR1A, ADCYAP1

Compounds for genes affiliated with Chronic Fatigue Syndrome

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Compounds related to Chronic Fatigue Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1p-chloroamphetamine439.6SLC6A4, MAOA, HTR1A
2carbon-11439.6HTR1A, MAOA, SLC6A4
35-hydroxytryptophan439.5HTR1A, CRH, SLC6A4
411 deoxycortisol439.5CRH, POMC, NR3C1
5mdma439.5MAOA, SLC6A4, HTR1A
6mhpg439.5CRH, SLC6A4, MAOA
7naratriptan43 28 1211.4NR3C1, MAOA, HTR1A
8betamethasone43 1210.4NR3C1, POMC, CRH
9homovanillic acid43 2410.4SLC6A4, CRH, MAOA
10mianserin43 28 1211.4SLC6A4, MAOA, HTR1A
11naltrexone43 28 49 1212.4LBR, POMC, CRH
12fenfluramine43 28 1211.3HTR1A, CRH, SLC6A4, POMC
13Serotonin249.3HTR1A, SLC6A4, MAOA
145-hydroxyindoleacetic acid43 2410.3MAOA, CRH, SLC6A4
15maoa439.3HTR1A, MAOA, SLC6A4, POMC
16fluvoxamine43 49 1211.2SLC6A4, MAOA, HTR1A
17clomipramine43 49 1211.2HTR1A, MAOA, SLC6A4, CRH
18fluoxetine43 49 28 1212.2MAOA, CRH, SLC6A4, HTR1A
19citalopram43 49 24 1212.2HTR1A, MAOA, CRH, SLC6A4
20metyrapone43 59 1211.2NR3C1, POMC, CRH
21mirtazapine43 49 1211.1SLC6A4, NR3C1, CRH, POMC
22ribonucleic acid439.0RNASEL, CRH, POMC, ADCYAP1
23opiate439.0SLC6A4, NR3C1, CRH, POMC
24dhea439.0POMC, CRH, NR3C1, IGFBP1
25sertraline43 28 49 24 1212.9HTR1A, MAOA, CRH, SLC6A4, POMC
26imipramine43 28 49 24 1212.9SLC6A4, MAOA, HTR1A, NR3C1
27cortisone43 249.9NR3C1, CRH, POMC
28hydrocortisone43 2 59 1211.9POMC, IGFBP1, NR3C1, CRH
29catecholamine438.8CRH, POMC, MAOA, ADCYAP1
30progestin438.8SLC6A4, NR3C1, POMC, IGFBP1
31haloperidol43 49 28 2 1212.7SLC6A4, HTR1A, ADCYAP1, POMC
32desipramine43 49 1210.6CRH, HTR1A, MAOA, NR3C1, SLC6A4
33mifepristone43 28 59 1211.6NR3C1, LBR, CRH, POMC, IGFBP1
34gnrh438.3POMC, IGFBP1, ADCYAP1, CRH, SLC6A4
35forskolin43 49 1210.2LBR, IGFBP1, POMC, ADCYAP1, CRH
365-hydroxytryptamine438.1SLC6A4, CRH, MAOA, HTR1A, ADCYAP1, POMC
37acetylcholine43 49 28 24 1211.9HTR1A, LBR, CRH, ADCYAP1, NR3C1, POMC
38acth437.9IGFBP1, HTR1A, ADCYAP1, CRH, NR3C1, POMC
39gaba437.9NR3C1, ADCYAP1, POMC, CRH, SLC6A4, MAOA
40progesterone43 28 59 24 1211.7LBR, CRH, ADCYAP1, POMC, NR3C1, IGFBP1
41steroid437.7POMC, ADCYAP1, IGFBP1, LBR, NR3C1, CRH
42arginine437.6RNASEL, POMC, IGFBP1, CRH, SLC6A4, LBR
43cycloheximide437.5CRH, POMC, NR3C1, ADCYAP1, RNASEL, IGFBP1
44epinephrine43 24 129.5MAOA, IGFBP1, ADCYAP1, POMC, SLC6A4, CRH
45dopamine43 28 24 1210.5MAOA, ADCYAP1, SLC6A4, HTR1A, NR3C1, CRH
46corticosterone43 59 249.4CRH, POMC, ADCYAP1, HTR1A, NR3C1, SLC6A4
47dexamethasone43 49 28 1210.4IGFBP1, LBR, POMC, ADCYAP1, CRH, NR3C1
48norepinephrine43 24 129.2CRH, MAOA, POMC, HTR1A, ADCYAP1, LBR
49serine436.8NR3C1, IGFBP1, SLC6A4, CRH, ADCYAP1, POMC
50testosterone43 59 24 129.6LBR, NR3C1, CRH, MAOA, ADCYAP1, SLC6A4

GO Terms for genes affiliated with Chronic Fatigue Syndrome

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Biological processes related to Chronic Fatigue Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:00140629.8CRH, HTR1A
2vasoconstrictionGO:00423109.6SLC6A4, HTR1A
3adrenal gland developmentGO:00303259.4NR3C1, CRH
4behavioral fear responseGO:00016629.0ADCYAP1, HTR1A
5signal transductionGO:00071658.7NR3C1, CRH, POMC, IGFBP1

Molecular functions related to Chronic Fatigue Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lamin bindingGO:00055219.6SUN2, LBR
2neuropeptide hormone activityGO:00051849.0CRH, ADCYAP1
3receptor bindingGO:00051029.0CRH, ADCYAP1, POMC

Products for genes affiliated with Chronic Fatigue Syndrome

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Sources for Chronic Fatigue Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet