Chronic Granulomatous Disease malady

NIH Rare Diseases: Chronic granulomatous disease (CGD) is a rare, inherited, primary immune deficiency disorder that affects certain white blood cells. It is characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Symptoms usually begin in infancy or childhood and include life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones; swollen areas of inflamed tissues known as granulomas; and other symptoms. It is caused by mutations in any one of four different genes and is usually inherited in an autosomal recessive or X-linked recessive manner. Treatment consists of continuous antibiotic therapy to help prevent infections and corticosteroid drugs for treating granulomatous complications.³⁰

MalaCards: Chronic Granulomatous Disease, also known as granulomatous disease, chronic, is related to chronic granulomatous disease due to deficiency of ncf and myeloperoxidase deficiency. An important gene associated with Chronic Granulomatous Disease is NCF1 (neutrophil cytosolic factor 1), and among its related pathways are Bacterial infections in CF airways and G-protein signaling_Rac2 regulation pathway. The compounds budesonide and nadph have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and brain, and related mouse phenotypes are respiratory system and liver/biliary system.

Genetics Home Reference: Chronic granulomatous disease is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Immunodeficiencies are conditions in which the immune system is not able to protect the body effectively from foreign invaders such as bacteria and fungi. Individuals with chronic granulomatous disease have recurrent bacterial and fungal infections. People with this condition often have areas of inflammation (granulomas) in various tissues that can be damaging to those tissues. The features of chronic granulomatous disease usually first appear in childhood, although some individuals do not show symptoms until later in life.¹⁷

Wikipedia: Chronic granulomatous disease (CGD) (also known as Bridges–Good syndrome, Chronic granulomatous...⁴⁴ more...

OMIM: 306400

GeneReviews summary for cgd

Aliases & Descriptions:

chronic granulomatous disease 6 7 15 30 17 8 granulomatous disease, chronic 30 16 17 43 cgd 6 15 16 17 autosomal recessive chronic granulomatous disease 17 granulomatous disease, chronic, x-linked 43 chronic granulomatous disease, x-linked 33 x-linked chronic granulomatous disease 17 chronic granulomatous disorder 44

immunodeficiency with thymoma 43 granulomatous disease chronic 32 congenital dysphagocytosis 6 granulomatous disorder 43 bridges-good syndrome 6 chronic disease 43 quie syndrome 6

Diseases related to chronic granulomatous disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 595)

id	Related Disease	Score	Top Affiliating Genes
1	chronic granulomatous disease due to deficiency of ncf	31.7	NCF1, NCF2
2	myeloperoxidase deficiency	31.3	MPO, CAT
3	osteomyelitis	30.5	CD79A, CD40LG, IL8, IFNG, CAT, TNF
4	combined immunodeficiency	28.2	CD40LG, IL4R, CCR1, IFNG, CORO1A, LTF
5	severe combined immunodeficiency	28.2	CD40LG, IL4R, CCR1, IFNG, CORO1A, LTF
6	acute lymphoblastic leukemia	28.1	MPO, MLL, IL4R, G6PD, CSF2, CSF3
7	immunodeficiency	28.1	CD79A, CD40LG, IL4R, IFNG, IDO1, TNF
8	mediastinitis	27.7	SELE, MPO, CD79A, MLL, CYBB, CSF3
9	respiratory failure	26.8	PDE4A, CAT, ELANE, G6PD
10	bronchitis	26.7	S100A8, S100A9, MPO, IL8, LTF, ELANE
11	hemophagocytic lymphohistiocytosis	26.7	IL8, GPT, IFNG, TNF, CYCS, STX11
12	primary biliary cirrhosis	26.4	CD79A, CD40LG, GPT, LTF, SLPI
13	iron deficiency anemia	26.4	CAT, TNF, LTF, G6PD, HBG2, CSF3
14	asthma	26.3	MPO, CD14, IL4R, IFNG, TNF
15	fabry disease	26.1	SELE, S100A8, S100A9, MPO, TNF
16	hemochromatosis	26.0	MT-CYB, MPO, GPT, TNF, EPO
17	systemic lupus erythematosus	26.0	SELE, S100A8, S100A9, MPO, CD79A, CD40LG
18	iron overload	25.9	GPT, CAT, TNF, SLPI, SLC11A1, EPO
19	hepatitis c	25.9	CD40LG, GPT, IFNG, IDO1, TNF, LTF
20	eczema	25.3	SELE, MPO, CD79A, CD14, CD40LG, IL4R
21	pemphigus	25.2	CD79A, CD40LG, IL1RAPL2, IL4R, IFNG, CAT
22	amyloidosis	25.0	CD79A, CD14, CD40LG, IL1RAPL2, IFNG, TNF
23	crohn's disease	25.0	MPO, IL1RAPL2, IL8, IFNG, IDO1, TNF
24	myelodysplastic syndrome	24.9	PDE4A, MPO, MLL, MECOM, PRDM16, CSF2
25	thrombocytopenia	24.8	SELE, CD79A, CD40LG, IL8, GPT, IFNG
26	celiac disease	24.2	SELE, MT-CYB, CD79A, CD14, CD40LG, IL4R
27	rheumatoid arthritis, association with	23.9	SELE, CD79A, IL8, GPT, IFNG, TNF
28	meningitis	23.9	SELE, MPO, CD79A, CD14, CD40LG, IL4R
29	thalassemia	23.7	SELE, GPT, IFNG, CAT, TNF, CYCS
30	sarcoidosis	23.2	SELE, S100A8, S100A9, CD79A, CD14, IL1RAPL2
31	anemia	23.2	SELE, CLEC11A, MPO, CD79A, CD14, CD40LG
32	leprosy	22.9	S100A8, S100A9, CD79A, CD40LG, IL8, IFNG
33	lymphoblastic leukemia	22.8	MPO, CD79A, CD40LG, MLL, MECOM, IL4R
34	inflammatory bowel disease	22.7	PDE4A, SELE, S100A8, S100A9, MPO, CD14
35	hepatitis	22.7	NCF2, SELE, RAC1, S100A9, MPO, CD79A
36	hypertension	22.3	NCF1C, NCF4, PDE4A, SELE, RAC1, MPO
37	rheumatoid arthritis	22.1	NCF4, PDE4A, SELE, RAC1, S100A8, S100A9
38	arthritis	21.7	NCF1, NCF1C, NCF4, PDE4A, SELE, RAC1
39	lupus erythematosus	21.5	NCF2, SELE, S100A8, S100A9, MPO, CD79A
40	nephropathy	21.0	SELE, S100A8, S100A9, MPO, CD79A, CD14
41	myeloid leukemia	20.0	SELE, RAC1, CLEC11A, MPO, CD79A, CD14
42	obesity	19.9	SELE, RAC1, MT-CYB, S100A8, S100A9, MPO
43	blindness	19.8	PDE4A, SELE, MPO, CD79A, CD40LG, IL1RAPL2
44	hypoxia	19.8	PDE4A, SELE, RAC1, MT-CYB, MPO, CD40LG
45	pneumonia	19.8	PDE4A, SELE, RAC1, KEL, MT-CYB, S100A8
46	multiple myeloma	19.5	RAC1, MT-CYB, MPO, CD79A, CD14, CD40LG
47	hepatocellular carcinoma	18.9	SELE, RAC1, S100A8, S100A9, MPO, CD14
48	myeloma	18.6	PDE4A, RAC1, MT-CYB, MPO, CD79A, CD14
49	pancreatitis	18.3	NCF2, PDE4A, SELE, RAC1, S100A8, S100A9
50	thyroiditis	17.7	PDE4A, SELE, RAC1, MT-CYB, S100A8, S100A9

Clinical features from OMIM: 306400

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to chronic granulomatous disease:

²²

MGI Mouse Phenotypes related to chronic granulomatous disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.2	ADA, PRDM16, CYBA, CD14, NCF1C
2	liver/biliary system phenotype	MP:0005370	8.7	EPO, ADA, DECR1, TLR5, IFNG, CCR1
3	tumorigenesis	MP:0002006	8.3	CSF2, PRF1, ELANE, CYBB, TNF, CAT
4	hematopoietic system phenotype	MP:0005397	7.7	EPO, MECOM, IL4R, CCR1, IDO1, CYCS
5	immune system phenotype	MP:0005387	7.2	SLC11A1, CSF2, PRDM16, NCF1C, NCF4, PDE4A
6	mortality/aging	MP:0010768	6.7	CYBB, LTBR, ELANE, G6PD, PRDM16, PRF1
7	cardiovascular system phenotype	MP:0005385	6.4	CYCS, NOX1, G6PD, TLR5, PRDM16, CXCL1
8	cellular phenotype	MP:0005384	6.3	CAT, CYCS, CORO1A, G6PD, TLR5, PRF1
9	homeostasis/metabolism phenotype	MP:0005376	4.8	ELANE, LTF, LTBR, NOX1, CYBB, DUOX2

Articles related to chronic granulomatous disease:

(show top 50)    (show all 219)

id	Title	Authors	Year	Affiliating Genes
1	Inheritance pattern and clinical aspects of 93 Irania n patients with chronic granulomatous disease. (21789723)	Fattahi F.... Moin M.	2011	NCF1
2	Hematologically important mutations: the autosomal re cessive forms of chronic granulomatous disease (second update). (20167518)	Roos D.... Stasia M.J.	2010	NCF2, NCF4, CYBA
3	Hematologically important mutations: X-linked chronic granulomatous disease (third update). (20729109)	Roos D.... Gallin J.I.	2010	CYBB
4	A novel point mutation in the CYBB gene promoter lead ing to a rare X minus chronic granulomatous disease variant--impact on the micr obicidal activity of neutrophils. (19708127)	Defendi F.... Stasia M.J.	2009	CYBB
5	Transfusion support for a patient with McLeod phenotype without chronic granulomatous disease and with antibodies to Kx and Km. (18167163)	Bansal I.... Baron B.W.	2008	KEL, XK
6	Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease. (18422995)	Teimourian S.... Parvaneh N.	2008	CYBA
7	Chronic granulomatous disease (CGD) mimicking neoplasms: a suspected mediastinal teratoma unmasking as thymic granulomas due to X-linked CGD, and 2 related cases. (19131770)	Hauck F.... Roesler J.	2008	CYBB
8	X-linked chronic granulomatous disease (CGD) caused by an intra-exonic splice mutation (CYBB exon 3, c.262G->A) is mimicking juvenile sarcoidosis. (17543165)	Brunner J.... Roesler J.	2007	CYBB
9	Genetic and mutational heterogeneity of autosomal recessive chronic granulomatous disease in Tunisia. (16937026)	El Kares R.... Dellagi M.K.	2006	NCF2, CYBA
10	Unusual polyclonal anti-gp91 peptide antibody interac tions with X-linked chronic granulomatous disease-derived human neutrophils are not from compensatory expression of Nox proteins 1, 3, or 4. (15693794)	Baniulis D.... Jesaitis A.J.	2005	CYBB, NOX1
11	Chronic granulomatous disease and other disorders of phagocyte function. (16304364)	Dinauer M.C.	2005	IFNG
12	Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells. (15338276)	Bionda C.... Stasia M.J.	2004	NCF2, CYBB
13	Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease. (14688376)	Kobayashi S.D.... DeLeo F.R.	2004	CD14, TLR5, CCR1
14	Itraconazole to prevent fungal infections in chronic granulomatous disease. (12802027)	Gallin J.I.... Holland S.M.	2003	IFNG
15	A case of Williams syndrome with p47-phox-deficient chronic granulomatous disease (14635404)	Kabuki T.... Oh-Ishi T.	2003	PDLIM1
16	Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils. (12421972)	Clark S.R.... O'Donnell V.B.	2002	MPO
17	Accelerated calcium influx and hyperactivation of neutrophils in chronic granulomatous disease. (11207656)	Tintinger G.R.... Anderson R.	2001	PDE4A, ELANE
18	Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells. (11045425)	Saulnier S.O.... Hossle J.P.	2000	CYBB
19	Treatment of hepatic abscesses in chronic granulomatous disease with granulocyte-macrophage colony-stimulating factor. (10619768)	Martino S.... Tovo P.A.	2000	CSF2
20	Elf-1 and PU.1 induce expression of gp91(phox) via a promoter element mutated in a subset of chronic granulomatous disease patients. (10233904)	Voo K.S.... Skalnik D.G.	1999	CYBB
21	Disseminated infection due to Chrysosporium zonatum in a patient with chronic granulomatous disease and review of non-Aspergillus fungal infections in patients with this disease. (9854057)	Roilides E.... Panteliadis C.	1999	IFNG
22	Autosomal recessive chronic granulomatous disease caused by novel mutations in NCF-2, the gene encoding the p67-phox component of phagocyte NADPH oxidase. (10598813)	Noack D.... Heyworth P.G.	1999	NCF2
23	Genetic analysis of 13 families with X-linked chronic granulomatous disease reveals a low proportion of sporadic patients and a high proportion of sporadic carriers. (9667376)	Ariga T.... Sakiyama Y.	1998	CYBB
24	Somatic triple mosaicism in a carrier of X-linked chronic granulomatous disease. (9414292)	de Boer M.... Roos D.	1998	CYBB
25	Dose-dependent enhancements by interferon-gamma on functional responses of neutrophils from chronic granulomatous disease patients. (9129047)	Ahlin A.... Palmblad J.	1997	IFNG
26	Identification of a double mutation (D160V-K161E) (sic) in the p67phox gene of a chronic granulomatous disease patient. (9070911)	Bonizzato A.... Dusi S.	1997	NCF2
27	Deficiency of p67phox, p47phox or gp91phox in chronic granulomatous disease does not impair leucocyte chemotaxis or motility. (9054662)	Zicha D.... Segal A.W.	1997	NCF2, CYBB
28	Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease. (8879195)	Leusen J.H.... Roos D.	1996	RAC1, NCF2
29	Interferon-gamma therapy for infection control in chronic granulomatous disease. (7645379)	Ohga S.... Ueda K.	1995	IFNG
30	Recombinant human interferon-gamma in patients with chronic granulomatous disease--European follow up study. (7607280)	Weening R.S.... Seger R.A.	1995	IFNG
31	Treatment with granulocyte colony-stimulating factor for pneumonia in a patient with a variant form of X-linked chronic granulomatous disease. (7542203)	Fukuda T.... Aoki N.	1995	CSF3
32	A new mutation in exon 12 of the gp91-phox gene leading to cytochrome b-positive X-linked chronic granulomatous disease. (7756659)	Azuma H.... Okuno A.	1995	CYBB
33	A 15-base pair (bp) palindromic insertion associated with a 3-bp deletion in exon 10 of the gp91-phox gene, detected in two patients with X-linked chronic granulomatous disease. (7607656)	Ariga T.... Matsumoto S.	1995	CYBB
34	Neutrophils and mononuclear cells from patients with chronic granulomatous disease release nitric oxide. (8390277)	Condino-Neto A.... de Nucci G.	1993	CYCS
35	Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. (8234321)	Zhen L.... Dinauer M.C.	1993	CYBB
36	Resolution of hepatic abscess after interferon gamma in chronic granulomatous disease. (8259876)	Hague R.A.... Cant A.J.	1993	IFNG
37	X-linked chronic granulomatous disease: correction of NADPH oxidase defect by retrovirus-mediated expression of gp91-phox. (8400270)	Porter C.D.... Kinnon C.	1993	CYBB
38	Decreased CD4+CD29+ (memory T) cells in patients with chronic granulomatous disease. (8450264)	Hasui M.... Kobayashi Y.	1993	IFNG
39	Chronic granulomatous disease presenting with osteomyelitis: favorable response to treatment with interferon-gamma. (1573009)	Gill P.J.... Hoffman E.B.	1992	IFNG
40	Treatment of patients with chronic granulomatous disease with recombinant human interferon-gamma does not improve neutrophil oxidative metabolism, cytochrome b558 content or levels of four anti-microbial proteins. (1572085)	MA1hlebach T.J.... Seger R.A.	1992	IFNG
41	Chronic granulomatous disease 100% corrected by displ acement bone marrow transplantation from a volunteer unrelated donor. (1468453)	Hobbs J.R.... el Tumi M.	1992	IFNG
42	Increased phagocytic activity of polymorphonuclear leukocytes of chronic granulomatous disease as determined with flow cytometric assay. (1849170)	Hasui M.... Kobayashi Y.	1991	MPO, CAT
43	In vivo interferon-gamma therapy augments the in vitro ability of chronic granulomatous disease neutrophils to damage Aspergillus hyphae. (1901332)	Rex J.H.... Melnick D.A.	1991	IFNG
44	Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat. (2011585)	Casimir C.M.... Segal A.W.	1991	NCF1
45	A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease. The International Chronic Granulomatous Disease Cooperative Study Group. (1846940)		1991	IFNG
46	Disseminated infection with Pseudallescheria boydii i n a patient with chronic granulomatous disease: response to gamma-interferon pl us antifungal chemotherapy. (1908570)	Phillips P.... Speert D.P.	1991	IFNG
47	Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid. (2398896)	Rodaway A.R.F.... Bentley D.L.	1990	NCF1, CLEC11A
48	Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. (2243141)	Dinauer M.C.... Orkin S.H.	1990	CYBB, CYBA, MT-CYB
49	Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease. (2547247)	Lomax K.J.... Malech H.L.	1989	NCF1
50	A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. (2556453)	Dinauer M.C.... Orkin S.H.	1989	CYBB

Genes related to chronic granulomatous disease according to GeneCards:

(show top 50)    (show all 58)

id	Symbol	Description	Score	GeneCards Section Context
1	NCF1	neutrophil cytosolic factor 1	11.1	Aliases & Descriptions, Publications, Summaries
2	NCF2	neutrophil cytosolic factor 2	11.1	Aliases & Descriptions, Publications, Summaries
3	CYBB	cytochrome b-245, beta polypeptide	11.1	Aliases & Descriptions, Publications, Orthologs, Summaries
4	CYBA	cytochrome b-245, alpha polypeptide	11.1	Publications, Summaries
5	NCF1C	neutrophil cytosolic factor 1C pseudogene	11.1	Summaries, Publications
6	NCF1B	neutrophil cytosolic factor 1B pseudogene	11.0	Publications
7	MT-CYB	mitochondrially encoded cytochrome b	11.0	Publications
8	CLEC11A	C-type lectin domain family 11, member A	11.0	Publications
9	XK	X-linked Kx blood group (McLeod syndrome)	11.0	Publications
10	NCF4	neutrophil cytosolic factor 4, 40kDa	11.0	Publications
11	CORO1A	coronin, actin binding protein, 1A	11.0	Publications
12	KEL	Kell blood group, metallo-endopeptidase	11.0	Publications
13	LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)	11.0	Publications
14	STX11	syntaxin 11	11.0	Publications
15	NOX1	NADPH oxidase 1	11.0	Publications
16	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	11.0	Publications
17	DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	11.0	Publications
18	DUOX2	dual oxidase 2	11.0
19	TLR5	toll-like receptor 5	11.0	Publications
20	PDLIM1	PDZ and LIM domain 1	11.0	Publications
21	CCR1	chemokine (C-C motif) receptor 1	11.0	Publications
22	S100A9	S100 calcium binding protein A9	11.0	Publications
23	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Publications
24	PRF1	perforin 1 (pore forming protein)	11.0	Publications
25	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0	Publications
26	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	11.0	Publications
27	DUOX1	dual oxidase 1	11.0
28	IFNG	interferon, gamma	11.0	Publications, UniProt Related
29	TSPO	translocator protein (18kDa)	11.0	Publications
30	IDO1	indoleamine 2,3-dioxygenase 1	11.0	Publications
31	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
32	HBG2	hemoglobin, gamma G	11.0	Publications
33	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0	Publications
34	S100A8	S100 calcium binding protein A8	11.0	Publications
35	MPO	myeloperoxidase	11.0	Publications
36	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
37	IL4R	interleukin 4 receptor	11.0	Publications
38	SELE	selectin E	11.0	Publications
39	CYCS	cytochrome c, somatic	11.0	Publications
40	ADA	adenosine deaminase	11.0	Publications
41	SETBP1	SET binding protein 1	11.0	Publications
42	RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	11.0	Publications
43	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
44	CAT	catalase	11.0	Publications
45	CD14	CD14 molecule	11.0	Publications
46	CD40LG	CD40 ligand	11.0	Publications
47	ELANE	elastase, neutrophil expressed	11.0	Publications
48	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
49	MECOM	MDS1 and EVI1 complex locus	11.0	Publications
50	LTF	lactotransferrin	11.0	Publications

Pathways related to chronic granulomatous disease according to GeneDecks:

(show all 40)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	TLR5
2	G-protein signaling_Rac2 regulation pathway41	10.6	CYBB, CYBA, NCF2, NCF1
3	G-protein signaling Rac2 regulation pathway10	10.6	CYBB, CYBA, NCF2, NCF1
4	Disease38	10.5	SLC11A1, CYBB, CYBA, NCF4, NCF2, NCF1
5	G-protein signaling_RAC1 in cellular process41	10.4	CYBB, CYBA, RAC1, NCF2, NCF1
6	G-protein signaling RAC1 in cellular process10	10.4	CYBB, CYBA, RAC1, NCF2, NCF1
7	Lymphocyte Signaling3	10.3	MECOM, NCF4, NCF2, NCF1
8	Leukocyte transendothelial migration20	10.3	NOX1, CYBB, CYBA, RAC1, NCF4, NCF2
9	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.2	CSF2
10	Immune response _CCR3 signaling in eosinophils41	10.2	CYBB, CYBA, RAC1, NCF2, NCF1
11	Immune response CCR3 signaling in eosinophils10	10.1	CYBB, CYBA, RAC1, NCF2, NCF1
12	Molecular Mechanisms of Cancer36	10.0	CXCL1, CYCS, CCR1, IL4R, ITGAX
13	Leishmaniasis20	10.0	CYBA, TNF, IFNG, NCF4, NCF2, NCF1
14	Phagosome20	9.8	CORO1A, NOX1, CYBB, CYBA, CD14, MPO
15	African trypanosomiasis20	9.8	TNF, IDO1, IFNG, SELE
16	Inhibitory action of Lipoxins on Superoxide production in neutrophils41	9.8	CYBB, CYBA, IL8, NCF4, NCF2, NCF1
17	Allograft rejection20	9.8	CD40LG, IFNG, TNF, PRF1
18	Osteoclast differentiation20	9.6	NOX1, CYBB, CYBA, TNF, IFNG, RAC1
19	Akt Signaling36	9.6	CSF2, CXCL1, TNF, CCR1, IL4R, ITGAX
20	Amoebiasis20	9.5	CSF2, CXCL1, IL8, CD14
21	Tuberculosis20	9.5	CORO1A, CYCS, TNF, IFNG, ITGAX, CD14
22	Amyotrophic lateral sclerosis (ALS)20	9.4	CYCS, TNF, CAT, RAC1
23	Immune response_Bacterial infections in normal airways41	9.4	CD14, IL8, IFNG, TLR5
24	Natural killer cell mediated cytotoxicity20	9.3	RAC1, IFNG, TNF, PRF1, CSF2
25	Transendothelial Migration of Leukocytes36	9.2	CYBA, CYBB, NOX1, CXCL1, CCR1, IL8
26	Immune response_MIF in innate immunity response41	9.0	TNF, IFNG, IL8, CD14
27	Immune response MIF in innate immunity response10	9.0	TNF, IFNG, IL8, CD14
28	Rheumatoid arthritis20	9.0	CSF2, CXCL1, TNF, IFNG, IL8
29	Cytokine production by Th17 cells in CF41	9.0	CSF3, CSF2, CXCL1, IL8, CD14
30	Cytokine production by Th17 cells in CF (Mouse model)41	9.0	CD14, IL8, CXCL1, CSF2, CSF3
31	Hematopoietic cell lineage20	8.8	CD14, IL4R, TNF, CSF2, CSF3, EPO
32	Toll-like receptor signaling pathway20	8.8	TLR5, TNF, IL8, CD14, RAC1
33	Malaria20	8.5	CSF3, TNF, IFNG, IL8, CD40LG, SELE
34	MIF Mediated Glucocorticoid Regulation36	8.4	CSF3, CSF2, CXCL1, TNF, IL8, CD14
35	MIF Regulation of Innate Immune Cells36	8.4	CSF3, CSF2, CXCL1, TNF, IL8, CD14
36	STAT3 Pathway36	8.2	CSF3, CSF2, CXCL1, TNF, CCR1, IL8
37	Rho Family GTPases36	8.2	CSF3, CSF2, CXCL1, IL8, ITGAX, RAC1
38	p38 Signaling36	7.8	CSF3, CSF2, CXCL1, TNF, CCR1, IL8
39	Antioxidant Action of Vitamin-C36	7.8	NCF1, CSF3, CSF2, CXCL1, NOX5, NOX1
40	Cytokine-cytokine receptor interaction20	7.6	EPO, CSF3, CSF2, CXCL1, LTBR, TNF

Compounds related to chronic granulomatous disease according to GeneDecks:

(show top 50)    (show all 241)

id	Compound	Score	Top Affiliating Genes
1	budesonide32 42 9 9	13.1	CSF2, LTF, PDE4A
2	nadph32 18	11.0	NCF1, NCF1B, NCF1C, NCF4, CLEC11A, CYBA
3	apocynin32	9.8	NCF2, SELE, RAC1, CYBA, MPO, CAT
4	n acetylcysteine32	9.6	SELE, CD79A, GPT, LTF, HBG2, CYBA
5	dmso32	9.5	G6PD, CYBB, S100A9, CCR1
6	phosphatidylserine32 9 9	11.4	LTF, SELE, RAC1, CYCS, CD14, CD79A
7	Heme9 18 9	11.4	CYCS, CYBB, CYBA, CAT, IDO1, MPO
8	ascorbic acid32 18	10.0	LTF, SLPI, G6PD, CD40LG, RAC1, MT-CYB
9	heparin32 9 18 9	11.8	IL1RAPL2, ITGAX, CD79A, CXCL1, SLPI, CSF2
10	zymosan32	8.8	LTF, TNF, MPO, PDE4A, CD14, ELANE
11	pge232	8.8	SLPI, CXCL1, LTF, IDO1, PDE4A, SELE
12	vitamin b1232	8.7	EPO, CD79A, ADA, G6PD, LTF, CD40LG
13	epinephrine32 9 18 9	11.6	HBG2, ADA, PDE4A, SELE, CD79A, IL1RAPL2
14	mycophenolate mofetil32 9 9	10.5	CD79A, CD40LG, GPT, CSF3, SELE, EPO
15	rolipram32 42	9.5	PDE4A, IL8, IFNG, TNF, ELANE, ADA
16	fluticasone propionate32 42 9 9	11.4	TNF, SELE, MPO, IL8, IFNG, ELANE
17	endotoxin32	8.4	IL1RAPL2, SLPI, S100A8, S100A9, CD14, LTF
18	arachidonic acid32 9 18 9	11.3	IL1RAPL2, RAC1, S100A9, ITGAX, TNF, IL4R
19	ribavirin32 34 9 9	11.1	CD40LG, GPT, EPO, ADA, CSF3, CSF2
20	cysteine32	8.0	CD40LG, RAC1, XK, SLPI, CSF2, HBG2
21	diphenyleneiodonium32	8.0	CYCS, NOX1, G6PD, CYBB, CYBA, DUOX1
22	sulfasalazine32 9 9	9.9	SELE, CXCL1, IL8, IL1RAPL2, TNF, CD40LG
23	n-formylmethionyl-leucylphenylalanine32	7.9	NCF2, LTF, CYBA, TNF, IL8, ITGAX
24	h2o232	7.9	CYBB, CYBA, DUOX2, DUOX1, IL1RAPL2, CD79A
25	oxygen32 18	8.8	NOX1, SLC11A1, CYCS, CYBB, ELANE, G6PD
26	norepinephrine32 9 18 9	10.8	CD40LG, CD14, LTF, ADA, CD79A, SELE
27	gm-csf32	7.8	CSF3, CSF2, CD14, IL8, IFNG, TNF
28	indomethacin32 9 9	9.8	TSPO, CYBB, ADA, PDE4A, MPO, CD79A
29	rantes32	7.7	TLR5, CXCL1, CSF2, CSF3, SLPI, SELE
30	butyrate32	7.7	EPO, SLPI, CYBB, CD14, IFNG, CYCS
31	cyclosporin a32 42	8.6	TSPO, CXCL1, SLPI, ELANE, LTF, GPT
32	pentoxifylline32 9 9	9.5	LTF, ELANE, CSF2, TNF, PDE4A, MPO
33	prednisolone32 9 9	9.4	MPO, MLL, IL1RAPL2, GPT, CD14, IFNG
34	methotrexate32 34 42 9 9	11.4	CXCL1, CSF3, IL1RAPL2, CD79A, TNF, GPT
35	hydrocortisone32 9 9	9.4	EPO, SLPI, CSF2, LTF, ELANE, TNF
36	fibrinogen32	7.3	CD40LG, ITGAX, SELE, RAC1, S100A9, CD79A
37	vegf32	7.2	PDE4A, SELE, CSF3, SLPI, EPO, CSF2
38	leukotriene b432 42 18	9.2	PDE4A, RAC1, MPO, ITGAX, IL1RAPL2, IL8
39	creatinine32	6.9	CD14, MPO, CD79A, MT-CYB, SELE, CD40LG
40	neopterin32	6.7	CD40LG, IL1RAPL2, IL8, GPT, IFNG, IDO1
41	nitric oxide32 9 18 9	9.5	CYCS, CYBB, CYBA, TNF, CAT, IDO1
42	histamine32 18	7.2	LTF, TSPO, CXCL1, CSF2, SLPI, ADA
43	fmlp32	6.2	NCF2, NCF4, PDE4A, RAC1, MT-CYB, S100A9
44	actinomycin d32	6.2	LTF, G6PD, CXCL1, CSF2, SLPI, CYCS
45	cycloheximide32	6.0	IL8, TNF, CYCS, PRF1, CXCL1, CSF2
46	dexamethasone32 42 34 9 9	9.7	PDE4A, S100A8, S100A9, CD79A, CD14, CD40LG
47	retinoic acid32 42 18	7.5	CCR1, IFNG, TNF, CYBB, LTBR, LTF
48	lactate32	5.4	CD40LG, IL1RAPL2, IL8, GPT, CAT, TNF
49	serine32	5.1	S100A8, CYBB, CYCS, LTBR, ELANE, G6PD
50	superoxide32 18	5.3	NOX5, LTF, ELANE, G6PD, HBG2, PRF1

Cellular components related to chronic granulomatous disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	NADPH oxidase complex	GO:043020	10.2	NCF1, NCF2, NCF4, CYBA, CYBB, NOX1
2	phagolysosome	GO:032010	10.2	NCF1, NCF2, NCF4
3	phagocytic cup	GO:001891	10.2	RAC1, CORO1A
4	phagocytic vesicle membrane	GO:030670	9.9	SLC11A1, CORO1A, CYBB, CYBA
5	external side of plasma membrane	GO:009897	9.0	ADA, TNF, IFNG, CCR1, ITGAX, CD40LG
6	extracellular space	GO:005615	6.6	TNF, CXCL1, CSF2, CSF3, ADA, EPO

Biological processes related to chronic granulomatous disease according to GeneDecks:

(show all 26)

id	Name	GO ID	Score	Top Affiliating Genes
1	hydrogen peroxide biosynthetic process	GO:050665	10.5	DUOX1, CYBA, CYBB
2	superoxide metabolic process	GO:006801	10.5	NOX1, CYBB, CYBA, NCF2, NCF1
3	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	10.5	CYBB, CYBA, NCF4, NCF2, NCF1
4	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	10.5	CYBB, CYBA, NCF4, NCF2, NCF1
5	respiratory burst	GO:045730	10.4	SLC11A1, NOX1, CYBB, CYBA, NCF2, NCF1
6	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	10.4	CYBB, CYBA, NCF4, NCF2, NCF1
7	electron transport chain	GO:022900	10.4	CYBA, CYBB, NOX1, NOX5
8	superoxide anion generation	GO:042554	10.3	NOX5, NOX1, CYBB, CYBA, DUOX1, NCF2
9	cuticle development	GO:042335	10.3	DUOX1, DUOX2
10	hydrogen peroxide catabolic process	GO:042744	10.2	DUOX2, DUOX1, CAT, MPO
11	interaction with host	GO:051701	10.1	SLC11A1, LTF, CYBB, CYBA, NCF4, NCF2
12	phagosome maturation	GO:090382	10.1	SLC11A1, LTF, CYBB, CYBA, NCF4, NCF2
13	phagocytosis	GO:006909	10.0	SLC11A1, ELANE, CORO1A, CD14
14	response to hyperoxia	GO:055093	10.0	NCF2, CAT, EPO
15	positive regulation of interleukin-12 production	GO:032735	10.0	CD40LG, IFNG, IDO1
16	positive regulation of osteoclast differentiation	GO:045672	9.9	TNF, IFNG, CCR1
17	positive regulation of vitamin D biosynthetic process	GO:060557	9.7	IFNG, TNF
18	oxidation-reduction process	GO:055114	9.7	G6PD, NOX5, NOX1, CYBB, CYBA, DUOX2
19	negative regulation of growth of symbiont in host	GO:044130	9.7	ELANE, TNF, IFNG
20	innate immune response	GO:045087	9.5	TLR5, CORO1A, CYBB, CYBA, IL1RAPL2, CD14
21	response to lipopolysaccharide	GO:032496	9.4	EPO, SLC11A1, ELANE, IDO1, S100A9, S100A8
22	cellular response to lipopolysaccharide	GO:071222	9.2	TSPO, IFNG, IL8, CD14
23	embryonic digestive tract development	GO:048566	9.1	ADA, TNF, IL8
24	immune response	GO:006955	8.2	CSF3, CSF2, CXCL1, CCR1, IL8, IL4R
25	apoptotic process	GO:006915	8.2	LTBR, TSPO, PRF1, EPO, CYCS, TNF
26	inflammatory response	GO:006954	7.7	SELE, SLC11A1, CXCL1, TLR5, NOX1, CYBB

Molecular functions related to chronic granulomatous disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol binding	GO:035091	10.2	NCF1, NCF1B, NCF1C, NCF4
2	superoxide-generating NADPH oxidase activity	GO:016175	10.1	NCF1, NOX5, NOX1, CYBB, CYBA, NCF1C
3	peroxidase activity	GO:004601	9.8	MPO, DUOX1, DUOX2
4	NADP binding	GO:050661	9.4	G6PD, NOX5, NOX1, DUOX1, CAT
5	heme binding	GO:020037	9.2	HBG2, NOX5, CYCS, CYBB, CYBA, DUOX2
6	protein binding	GO:005515	4.4	LTBR, CORO1A, NOX1, CYCS, CYBB, CYBA