CGD
MCID: CHR012
MIFTS: 63

Chronic Granulomatous Disease (CGD) malady

Immune category

Summaries for Chronic Granulomatous Disease

Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Chronic granulomatous disease (cgd) is a rare, inherited, primary immune deficiency disorder that affects certain white blood cells. it is characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. symptoms usually begin in infancy or childhood and include life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones; swollen areas of inflamed tissues known as granulomas; and other symptoms. it is caused by mutations in any one of four different genes and is usually inherited in an autosomal recessive or x-linked recessive manner. treatment consists of continuous antibiotic therapy to help prevent infections and corticosteroid drugs for treating granulomatous complications. last updated: 5/12/2011

MalaCards: Chronic Granulomatous Disease, also known as granulomatous disease, chronic, is related to aspergillosis and tuberculosis. An important gene associated with Chronic Granulomatous Disease is CYBB (cytochrome b-245, beta polypeptide), and among its related pathways are Cytoskeleton remodeling CDC42 in cellular processes and G-protein signaling Rac2 regulation pathway. The compounds flavin and apocynin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and brain, and related mouse phenotypes are homeostasis/metabolism and immune system.

Genetics Home Reference:21 Chronic granulomatous disease is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Immunodeficiencies are conditions in which the immune system is not able to protect the body effectively from foreign invaders such as bacteria and fungi. Individuals with chronic granulomatous disease have recurrent bacterial and fungal infections. People with this condition often have areas of inflammation (granulomas) in various tissues that can be damaging to those tissues. The features of chronic granulomatous disease usually first appear in childhood, although some individuals do not show symptoms until later in life.

Wikipedia:64 Chronic granulomatous disease (CGD) (also known as Bridges–Good syndrome, Chronic granulomatous... more...

Description from OMIM:47 306400,233710,233700,233690

GeneReviews summary for cgd

Aliases & Classifications for Chronic Granulomatous Disease

Sources:
8Disease Ontology, 64Wikipedia, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

chronic granulomatous disease 8 19 43 21 10 31
granulomatous disease, chronic 43 20 22 21 61
cgd 8 19 21
autosomal recessive chronic granulomatous disease 21
granulomatous disease, chronic, x-linked 61
chronic granulomatous disease, x-linked 47
x-linked chronic granulomatous disease 21
chronic granulomatous disorder 64
granulomatous disease chronic 45
immunodeficiency with thymoma 61
congenital dysphagocytosis 8
bridges-good syndrome 8
quie syndrome 8


External Ids:

Disease Ontology8 DOID:3265
NCIt40 C26788
MeSH35 D006105

Related Diseases for Chronic Granulomatous Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Chronic Granulomatous Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis31.0IFNG, MT-CYB, NCF2
2tuberculosis30.4PRF1, IFNG, CCR1
3hemophagocytic lymphohistiocytosis30.4PRF1, STX11
4autosomal recessive disease10.8
5invasive aspergillosis10.6
6discoid lupus erythematosus10.6
7hematopoietic stem cell transplantation10.5
8brain disease10.5
9mcleod syndrome10.4
10job's syndrome10.4
11mu chain disease10.4
12chronic granulomatous disease, autosomal recessive, cytochrome b-positive, type iii10.4
13chronic granulomatous disease, autosomal, due to deficiency of cyba10.4
14chronic granulomatous disease, autosomal recessive, cytochrome b-negative10.4
15chronic granulomatous disease, x-linked10.4
16m�ni�re disease10.4
17lip disease10.4
18good syndrome10.3
19nocardiosis10.3
20kawasaki disease10.3
21n syndrome10.3
22splenic disease10.3
23williams syndrome10.3
24chronic granulomatous disease, autosomal recessive, cytochrome b-positive, type i10.3
25chronic granulomatous disease, autosomal recessive, cytochrome b-positive, type ii10.3
26mcleod syndrome with or without chronic granulomatous disease10.3
27gastric outlet obstruction10.3
28acalculous cholecystitis10.2
29chediak-higashi syndrome10.2
30visceral leishmaniasis10.2
31leukocyte adhesion deficiency10.2
32retinitis pigmentosa10.2
33splenic abscess10.2
34celiac disease10.2
35duchenne muscular dystrophy10.2
36acne10.2
37autosomal genetic disease10.2
38thrombocytopenia10.2
39uveitis10.2
40eosinophilic cystitis10.2
41chronic granulomatous disease due to deficiency of ncf-210.2
42chronic granulomatous disease due to deficiency of ncf-110.2
43primary immunodeficiency disease10.2
44thymoma10.1
45swyer syndrome10.1
46nr5a1-related 46,xy dsd and 46,xy cgd10.1
47dhh-related 46,xy dsd and 46,xy cgd10.1
48nr0b1-related 46,xy dsd and 46,xy cgd10.1
49wnt4-related 46,xy dsd and 46,xy cgd10.1
50map3k1-related 46,xy dsd and 46,xy cgd10.1

Graphical network of the top 20 diseases related to Chronic Granulomatous Disease:



Diseases related to chronic granulomatous disease

Clinical Features for Chronic Granulomatous Disease

Sources:
47OMIM
See all sources

Clinical features from OMIM:

306400,233710,233700,233690

Clinical synopsis from OMIM:

306400

Drugs & Therapeutics for Chronic Granulomatous Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Granulomatous Disease

Drug clinical trials:

Search ClinicalTrials for Chronic Granulomatous Disease

Search NIH Clinical Center for Chronic Granulomatous Disease

Search CenterWatch for Chronic Granulomatous Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Granulomatous Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Granulomatous Disease:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Embryonic/Adult Cultured Cells Related to Chronic Granulomatous Disease:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905

Genetic Tests for Chronic Granulomatous Disease

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Chronic Granulomatous Disease:

id Genetic test Affiliating Genes
1 Chronic Granulomatous Disease20 22 NCF4

Anatomical Context for Chronic Granulomatous Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Chronic Granulomatous Disease:

33
Bone marrow, Thymus, Brain, Spinal cord, Colon, Liver, Lung, Skin, Prostate, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Fetal brain, Fetal liver, Fetal lung

Animal Models for Chronic Granulomatous Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Chronic Granulomatous Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8IFNG, STX11, PRF1, DECR1, NCF1C, LTBR
2MP:00053879.4NOX1, CORO1A, CCR1, IFNG, STX11, ITGAX

Publications for Chronic Granulomatous Disease

Sources:
51PubMed
See all sources

Articles related to Chronic Granulomatous Disease:

(show top 50)    (show all 720)
idTitleAuthorsYear
1
Refractory invasive aspergillosis controlled with posaconazole and pulmonary surgery in a patient with chronic granulomatous disease: case report. (24401677)
2014
2
Pulmonary computed tomography scan findings in chronic granulomatous disease. (23850120)
2013
3
Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis. (23808662)
2013
4
Successful treatment of Aspergillus flavus spondylodiscitis with epidural abscess in a patient with chronic granulomatous disease. (21873929)
2012
5
Residual NADPH oxidase activity and isolated lung involvement in x-linked chronic granulomatous disease. (23193493)
2012
6
PEGylated D-amino acid oxidase restores bactericidal activity of neutrophils in chronic granulomatous disease via hypochlorite. (22715431)
2012
7
Actinomycosis and nocardiosis co-infection in chronic granulomatous disease. (23029749)
2012
8
Adenosine A(2A) receptor activation limits chronic granulomatous disease-induced hyperinflammation. (21130984)
2011
9
Chronic granulomatous disease of childhood: an unusual cause of recurrent uncommon infections in a 61-year-old man. (21623884)
2011
10
Successful treatment with percutaneous transhepatic alcoholization of a liver abscess in a child with chronic granulomatous disease. (21849867)
2011
11
Hyperinflammatory pulmonary disease in chronic granulomatous disease. (21730887)
2011
12
Atypical presentation of chronic granulomatous disease in an adolescent boy with frontal lobe located Aspergillus abscess mimicking intracranial tumor. (19859718)
2010
13
PPARI^ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease. (20693431)
2010
14
Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease. (20495074)
2010
15
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. (20098431)
2010
16
Rapid genetic analysis of x-linked chronic granulomatous disease by high-resolution melting. (20228266)
2010
17
Carriers of X-linked chronic granulomatous disease at risk. (19004669)
2009
18
Identification of deletion carriers in X-linked chronic granulomatous disease by real-time PCR. (19839755)
2009
19
Actinomyces in chronic granulomatous disease: an emerging and unanticipated pathogen. (19874205)
2009
20
Alternaria infectoria brain abscess in a child with chronic granulomatous disease. (18815820)
2009
21
Visceral leishmaniasis associated hemophagocytic syndrome in patients with chronic granulomatous disease. (19633526)
2009
22
A chronic granulomatous disease of childhood. (22303514)
2009
23
Respiratory complications after haematopoietic stem cell transplantation in a patient with chronic granulomatous disease. (19320854)
2009
24
Clinical features, long-term follow-up and outcome of a large cohort of patients with Chronic Granulomatous Disease: an Italian multicenter study. (18037347)
2008
25
Transfusion support for a patient with McLeod phenotype without chronic granulomatous disease and with antibodies to Kx and Km. (18167163)
2008
26
Fulminant mulch pneumonitis: an emergency presentation of chronic granulomatous disease. (17712749)
2007
27
Chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency both yield strongly reduced dihydrorhodamine 123 test signals but can be easily discerned in routine testing for CGD. (17384005)
2007
28
Bacteria-associated haemophagocytic syndrome and septic pulmonary embolism caused by Burkholderia cepacia complex in a woman with chronic granulomatous disease. (17446299)
2007
29
Severe X-linked chronic granulomatous disease in two unrelated females. (17089090)
2007
30
Clinical and laboratory aspects of chronic granulomatous disease in description of eighteen patients. (15693905)
2005
31
Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. (15889369)
2005
32
Outpatient treatment with corticosteroids and antibiotics for acalculous cholecystitis in chronic granulomatous disease. (16303712)
2005
33
Francisella philomiragia adenitis and pulmonary nodules in a child with chronic granulomatous disease. (18159552)
2005
34
Successful treatment of Paecilomyces variotii splenic abscesses: a rare complication in a previously unrecognized chronic granulomatous disease child. (16168619)
2005
35
Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells. (15338276)
2004
36
Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease. (14688376)
2004
37
Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis. (14645984)
2003
38
Rapid prenatal diagnosis of X-linked chronic granulomatous disease using a denaturing high-performance liquid chromatography (DHPLC) system. (14691999)
2003
39
Therapeutic effect of interferon-gamma for prevention of severe infection in X-linked chronic granulomatous disease. (12783137)
2003
40
Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils. (12421972)
2002
41
Characterization of 11 novel mutations in the X-linked chronic granulomatous disease (CYBB gene). (11462241)
2001
42
Molecular analysis of 9 new families with chronic granulomatous disease caused by mutations in CYBA, the gene encoding p22(phox). (10910929)
2000
43
Chronic granulomatous disease in Japan: incidence and natural history. The Study Group of Phagocyte Disorders of Japan. (10530081)
1999
44
Sensitization to Aspergillus species in the congenital neutrophil disorders chronic granulomatous disease and hyper-IgE syndrome. (10589011)
1999
45
Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood. (8188451)
1993
46
Chronic Granulomatous Disease (22876374)
1993
47
Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox). (1415254)
1992
48
Granulocyte-macrophage colony stimulating factor does not improve neutrophil oxidative metabolism in a patient with variant X-linked chronic granulomatous disease. (1659535)
1991
49
Disseminated infection with Pseudallescheria boydii in a patient with chronic granulomatous disease: response to gamma-interferon plus antifungal chemotherapy. (1908570)
1991
50
Discoid lupus erythematosus and X-linked chronic granulomatous disease. (3809020)
1986

Genetic Variations for Chronic Granulomatous Disease

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Chronic Granulomatous Disease:

63 (show all 59)
id Symbol AA change Variation SNP ID
1CYBBp.His101ArgVAR_002432rs137854591
2CYBBp.Ala156ThrVAR_002433rs137854590
3CYBBp.His209TyrVAR_002434rs137854587
4CYBBp.Glu225ValVAR_002435rs151344494
5CYBBp.Cys244SerVAR_002436rs137854589
6CYBBp.Cys244TyrVAR_002437rs137854589
7CYBBp.Pro339HisVAR_002438rs151344470
8CYBBp.Gly389AlaVAR_002439rs137854586
9CYBBp.Pro415HisVAR_002440rs137854585
10CYBBp.Asp500GlyVAR_002441rs137854593
11CYBBp.Gly20ArgVAR_007873rs151344455
12CYBBp.Arg54SerVAR_007874rs151344456
13CYBBp.Cys59ArgVAR_007875rs151344457
14CYBBp.His101TyrVAR_007876rs137854594
15CYBBp.His119ArgVAR_007877rs151344458
16CYBBp.His209GlnVAR_007878rs151344459
17CYBBp.His222AsnVAR_007880rs151344460
18CYBBp.His222ArgVAR_007881rs151344462
19CYBBp.His222TyrVAR_007882rs151344460
20CYBBp.Gly223LeuVAR_007883rs151344463
21CYBBp.Cys244ArgVAR_007884rs151344465
22CYBBp.Glu309LysVAR_007885rs151344466
23CYBBp.Gly322GluVAR_007886rs151344467
24CYBBp.Ile325PheVAR_007887rs151344468
25CYBBp.Ser333ProVAR_007888rs151344469
26CYBBp.Arg356ProVAR_007889rs151344471
27CYBBp.Met405ArgVAR_007890rs151344472
28CYBBp.Gly408GluVAR_007891rs151344474
29CYBBp.Gly408ArgVAR_007892rs151344473
30CYBBp.Pro415LeuVAR_007893rs137854585
31CYBBp.Ser422ProVAR_007894rs151344475
32CYBBp.Trp453ArgVAR_007895rs151344476
33CYBBp.Trp516CysVAR_007896rs151344477
34CYBBp.Val534AspVAR_007897rs151344478
35CYBBp.Cys537ArgVAR_007898rs151344454
36CYBBp.Ala57GluVAR_008845rs151344481
37CYBBp.His303AsnVAR_016880rs137854595
38CYBBp.Pro304ArgVAR_016881rs137854596
39CYBBp.Tyr41AspVAR_025613rs151344453
40CYBBp.Arg54MetVAR_025614rs151344479
41CYBBp.Ala55AspVAR_025615rs151344480
42CYBBp.His209ArgVAR_025616rs151344482
43CYBBp.Ala224GlyVAR_025617rs151344483
44CYBBp.His338TyrVAR_025618rs151344484
45CYBBp.Ser344PheVAR_025619rs151344485
46CYBBp.Gly389GluVAR_025621rs137854586
47CYBBp.Leu420ProVAR_025622rs151344486
48CYBBp.Trp516ArgVAR_025623rs151344487
49CYBBp.Trp18CysVAR_047264
50CYBBp.Cys59TrpVAR_047266rs151344488
51CYBBp.Gly179ArgVAR_047267rs151344491
52CYBBp.Ser193PheVAR_047268rs151344493
53CYBBp.Phe205IleVAR_047269rs151344496
54CYBBp.Thr307ProVAR_047271rs151344489
55CYBBp.Leu342GlnVAR_047273rs151344495
56CYBBp.Leu505ArgVAR_047275rs151344490
57CYBBp.Leu546ProVAR_047276rs151344492
58CYBBp.Ala488AspVAR_068012
59CYBBp.Asp500GluVAR_068013

Expression for genes affiliated with Chronic Granulomatous Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Granulomatous Disease

Search GEO for disease gene expression data for Chronic Granulomatous Disease.

Pathways for genes affiliated with Chronic Granulomatous Disease

Sources:
12EMD Millipore, 54Reactome, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Chronic Granulomatous Disease according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cytoskeleton remodeling CDC42 in cellular processes
Hide members
10.3CYBB, CYBA, NCF2, NCF1
210.3NCF1, NCF2, CYBA, CYBB
3
Immune response CCR3 signaling in eosinophils
Hide members
10.3NCF1, NCF2, CYBA, CYBB
410.2CYBB, CYBA, NCF4, NCF2, NCF1
5
Hide members
10.2NCF1, NCF2, NCF4, CYBA, CYBB
6
Hide members
10.2NCF1, NCF2, NCF4, CYBA, CYBB
7
Inhibitory action of Lipoxins on Superoxide production in neutrophils
10.2NCF1, NCF2, NCF4, CYBA, CYBB
8
Hide members
10.2IFNG, NCF1, NCF2, NCF4, CYBA
910.2NOX1, CYBB, LTBR, IFNG
10
Hide members
10.2NOX1, CYBB, CYBA, NCF2, NCF1
11
Hide members
10.2CYBB, CYBA, NCF4, NCF2, NCF1, IFNG
12
Hide members
10.2IFNG, NCF1, NCF2, NCF4, CYBA, CYBB
1310.2STX11, NCF1, NCF2, NCF4, CYBA, CYBB
1410.2NCF1, NCF2, NCF4, CYBA, CYBB, NOX1
15
Hide members
10.1CCR1, NCF1, NCF2, NCF4, CYBB, NOX1
1610.1IFNG, NCF1, NCF2, NCF4, CYBA, CYBB
1710.1CORO1A, NCF1, NCF2, NCF4, CYBA, CYBB
18
Hide members
10.0CCR1, ITGAX, NCF1, NCF2, NCF4, CYBA

Compounds for genes affiliated with Chronic Granulomatous Disease

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Chronic Granulomatous Disease according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1flavin4510.6MT-CYB, NCF2, CYBA, CYBB
2apocynin45 6011.6NCF2, CYBA, CYBB, NOX1
3diphenyleneiodonium4510.5NCF2, CYBA, CYBB, NOX1
4butyrate4510.4CCR1, IFNG, ITGAX, NCF2, CYBB
5fmlp4510.4ITGAX, MT-CYB, NCF2, NCF4
6n-formylmethionyl-leucylphenylalanine4510.4ITGAX, NCF2, CYBA
7heme29 11 2412.4NOX1, CYBB, CYBA, MT-CYB
8arachidonic acid45 29 11 2413.4ITGAX, NCF2, NCF4, CYBA, CYBB
9fumarate45 1111.4MT-CYB, IFNG
10histidine4510.3MT-CYB, PRF1, CYBA, CYBB
11oxygen45 2411.3ITGAX, MT-CYB, NCF2, NCF4, CYBA, CYBB
12nitric oxide45 11 2412.3CCR1, IFNG, ITGAX, MT-CYB, NCF2, CYBA
13retinoic acid45 2411.3CCR1, IFNG, ITGAX, NCF2, LTBR, CYBB
14cycloheximide4510.3PRF1, MT-CYB, ITGAX, IFNG, CCR1
15superoxide45 2411.2PRF1, MT-CYB, ITGAX, CCR1, NCF2, NCF4
16h2o24510.2MT-CYB, NCF2, CYBA, CYBB, NOX1
17nadh45 11 2412.2MT-CYB, NCF2, CYBA, CYBB
18hocl4510.1CYBA, NCF2
19nadph45 2411.1NOX1, CORO1A, MT-CYB, DECR1, NCF1, NCF2

GO Terms for genes affiliated with Chronic Granulomatous Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Chronic Granulomatous Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:03067010.3CYBB, CYBA, CORO1A
2NADPH oxidase complexGO:04302010.1NOX1, CYBB, CYBA, NCF4, NCF2, NCF1
3phagolysosomeGO:03201010.0NCF1, NCF2, NCF4

Biological processes related to Chronic Granulomatous Disease according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1hydrogen peroxide biosynthetic processGO:05066510.5CYBB, CYBA, NCF1
2respiratory burstGO:04573010.5NOX1, CYBB, CYBA, NCF2, NCF1
3interaction with hostGO:05170110.5NCF1, NCF2, NCF4, CYBA, CYBB
4superoxide anion generationGO:04255410.5NCF1, NCF2, CYBA, CYBB, NOX1
5phagosome maturationGO:09038210.5CYBB, CYBA, NCF4, NCF2, NCF1
6superoxide metabolic processGO:00680110.5NOX1, CYBB, CYBA, NCF2, NCF1
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.5NCF1, NCF2, NCF4, CYBA, CYBB
8antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.5NCF1, NCF2, NCF4, CYBA, CYBB
9antigen processing and presentation of peptide antigen via MHC class IGO:00247410.4NCF1, NCF2, NCF4, CYBA, CYBB
10cell communicationGO:00715410.4NCF1, NCF1C, NCF4, NCF1B
11oxidation-reduction processGO:05511410.4NOX1, CYBB, CYBA, NCF4
12cellular defense responseGO:00696810.3NCF2, NCF1, PRF1
13defense response to virusGO:05160710.3PRF1, ITGAX, IFNG
14inflammatory responseGO:00695410.3CCR1, NCF1, CYBA, CYBB, NOX1
15innate immune responseGO:04508710.1CORO1A, NCF1, NCF2, CYBA, CYBB
16positive regulation of osteoclast differentiationGO:04567210.1IFNG, CCR1

Molecular functions related to Chronic Granulomatous Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Rac GTPase bindingGO:04836510.3NOX1, NCF2
2phosphatidylinositol bindingGO:03509110.2NCF1, NCF1C, NCF4, NCF1B
3superoxide-generating NADPH oxidase activityGO:01617510.1NOX1, CYBB, CYBA, NCF1B, NCF1C, NCF2
4electron carrier activityGO:00905510.0CYBB, CYBA, NCF2, NCF1
5protein bindingGO:0055159.5XK, CORO1A, CCR1, KEL, STX11, ITGAX

Products for genes affiliated with Chronic Granulomatous Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Granulomatous Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet