MCID: CHR281
MIFTS: 27

Chronic Hiccups malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Chronic Hiccups

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Aliases & Descriptions for Chronic Hiccups:

Name: Chronic Hiccups 45
Intractable Singultus 45
Hiccups, Intractable 45
Intractable Hiccups 45
 
Persistent Hiccups 45
Chronic Hiccough 51
Chronic Hiccup 51

Characteristics:

Orphanet epidemiological data:

51
chronic hiccough:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 396

Summaries for Chronic Hiccups

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NIH Rare Diseases:45 Chronic hiccups are unintentional movements (spasms) of the diaphragm followed by rapid closure of the vocal cords that persist for an extended period of time. hiccups often develop for no apparent reason and typically go away on their own after a couple minutes. however, chronic hiccups last over two days and in rare cases, may continue for over a month. hiccups that recur over long periods of time are also considered "chronic." depending on how long the hiccups last, affected people may become exhausted, dehydrated and/or lose weight due to interruptions in sleep and normal eating patterns. other complications may include irregular heart beat and gastroesophageal reflux. the exact underlying cause is often unknown; some cases may be caused by surgery, certain medications and/or a variety of health problems such as central nervous system (brain and spinal cord) abnormalities, psychological problems, conditions that irritate the diaphragm, and metabolic diseases. treatment of chronic hiccups varies but may include medications and/or surgery. last updated: 12/23/2014

MalaCards based summary: Chronic Hiccups, also known as intractable singultus, is related to neuromyelitis optica and hemangioblastoma, and has symptoms including functional respiratory abnormality, abnormality of movement and recurrent singultus. Affiliated tissues include brain, spinal cord and heart.

Related Diseases for Chronic Hiccups

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Graphical network of the top 20 diseases related to Chronic Hiccups:



Diseases related to chronic hiccups

Symptoms for Chronic Hiccups

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Symptoms:

 51 (show all 14)
  • functional anomalies of the respiratory system and diaphragm
  • chronic hiccup
  • movement disorder
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • angor pectoris/myocardial infarction
  • renal failure
  • diabetes insipidus
  • transient cerebral ischemia/stroke
  • sleep and vigilance disorders
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • fever/chilling
  • dehydration/hydroelectrolytic loss

HPO human phenotypes related to Chronic Hiccups:

(show all 11)
id Description Frequency HPO Source Accession
1 functional respiratory abnormality hallmark (90%) HP:0002795
2 abnormality of movement hallmark (90%) HP:0100022
3 recurrent singultus hallmark (90%) HP:0100247
4 renal insufficiency occasional (7.5%) HP:0000083
5 diabetes insipidus occasional (7.5%) HP:0000873
6 coronary artery disease occasional (7.5%) HP:0001677
7 dehydration occasional (7.5%) HP:0001944
8 sleep disturbance occasional (7.5%) HP:0002360
9 cerebral ischemia occasional (7.5%) HP:0002637
10 abnormality of temperature regulation occasional (7.5%) HP:0004370
11 neoplasm of the nervous system occasional (7.5%) HP:0004375

Drugs & Therapeutics for Chronic Hiccups

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Drugs for Chronic Hiccups (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Baclofenapproved911134-47-02284
Synonyms:
( inverted question mark)-Baclofen
(+-)-Baclofen
(+/-)- beta-(Aminoethyl)-4- chlorobenzenepropanoic acid
(+/-)-BACLOFEN
(+/-)-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
(?)-Baclofen
1134-47-0
4-Amino-3-(4-chlorophenyl)butanoic acid
4-Amino-3-(4-chlorophenyl)butyric acid
62594-36-9
AB00051921
AC-4530
AC1L1DC6
ASTA Medica Brand of Baclofen
AWD, Baclofen
Alphapharm Brand of Baclofen
Apo Baclofen
Apo-Baclofen
ApoBaclofen
Apotex Brand of Baclofen
Ashbourne Brand of Baclofen
Athena Brand of Baclofen
Atrofen
B 5399
B3343
B5399_SIGMA
BPBio1_000012
BPBio1_000750
BRD-A84174873-001-05-2
BRN 2104494
BSPBio_000010
BSPBio_001880
Ba 34647
Ba-34,647
Ba-34647
Ba34,647
Ba34647
Baclofen
Baclofen (JP15/USP/INN)
Baclofen (R,S)
Baclofen AWD
Baclofen Alphapharm Brand
Baclofen Apotex Brand
Baclofen Ashbourne Brand
Baclofen Athena Brand
Baclofen Ciba-Geigy Brand
Baclofen Irex Brand
Baclofen Isis Brand
Baclofen Medtronic Brand
Baclofen Novartis Brand
Baclofen Nu-Pharm Brand
Baclofen Pharmascience Brand
Baclofen [USAN:INN:BAN:JAN]
Baclofene
Baclofene Irex
Baclofene [INN-French]
Baclofene-Irex
BaclofeneIrex
Baclofeno
Baclofeno [INN-Spanish]
Baclofenum
Baclofenum [INN-Latin]
Baclon
Baclophen
Baclospas
Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-(9CI)
Biomol-NT_000251
C 34647Ba
C10H12ClNO2
CCRIS 3722
CHEBI:2972
CHEMBL701
CIBA-34,647-BA
CIBA34,647BA
CID2284
Chlorophenyl GABA
Ciba 34,647-Ba
Ciba Geigy Brand of Baclofen
Ciba-Geigy Brand of Baclofen
Clofen
D001418
D00241
DB00181
DL-4-Amino-3-P-chlorophenylbutanoic acid
DL-4-Amino-3-p-chlorophenylbutanoic acid
DL-Baclofen
 
DivK1c_000001
EINECS 214-486-9
EU-0100163
GABA, Chlorophenyl
Gabalon
Gablofen
Gen Baclofen
Gen-Baclofen
GenBaclofen
Genpharm
HMS1568A12
HMS1920E21
HMS2091M03
HMS500A03
I01-1934
IDI1_000001
Irex Brand of Baclofen
Isis Brand of Baclofen
KBio1_000001
KBio2_000466
KBio2_003034
KBio2_005602
KBio3_001380
KBioGR_000650
KBioSS_000466
Kemstro
Kemstro (TN)
L000002
LS-77134
Lebic
Lioresal
Lioresal (TN)
Lioresal Intrathecal
Lopac0_000163
MLS000028480
Medtronic Brand of Baclofen
MolPort-002-051-370
NCGC00015156-05
NCGC00015156-12
NCGC00023843-03
NCGC00024579-03
NCGC00024579-04
NCGC00024579-05
NCGC00024579-06
NINDS_000001
NSC329137
Novartis Brand of Baclofen
Nu Baclo
Nu Pharm Brand of Baclofen
Nu-Baclo
Nu-Baclofen
Nu-Pharm Brand of Baclofen
NuBaclo
Oprea1_440627
PCP-GABA
PMS Baclofen
PMSBaclofen
Pharmascience Brand of Baclofen
Pms-Baclofen
Prestwick0_000085
Prestwick1_000085
Prestwick2_000085
Prestwick3_000085
Prestwick_85
SMP1_000036
SMR000058294
SPBio_000044
SPBio_001949
SPECTRUM1500135
STK535284
STOCK2S-30552
Spectrum2_000092
Spectrum3_000310
Spectrum4_000245
Spectrum5_000852
Spectrum_000066
UNII-H789N3FKE8
UPCMLD-DP142
UPCMLD-DP142:001
baclofen
beta-(4-Chlorophenyl)gaba
beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
beta-(Aminomethyl)-P-chlorohydrocinnamic acid
beta-(Aminomethyl)-p-chlorohydrocinnamic acid
beta-(P-Chlorophenyl)-gamma-aminobutyric acid
beta-(p-Chlorophenyl)-gamma-aminobutyric acid
gamma-Amino-beta-(P-chlorophenyl)butyric acid
gamma-Amino-beta-(p-chlorophenyl)butyric acid
2Neurotransmitter Agents14795
3
Gamma-Aminobutyric acid7556-12-2119
Synonyms:
3-Carboxypropylamine
4-Aminobutanoate
4-Aminobutanoic acid
4-Aminobutyrate
4-Aminobutyric acid
Aminalon
GABA
Gaballon
Gamarex
Gammalon
Gammalone
Gammar
Gammasol
 
Mielogen
Mielomade
Omega-Aminobutyrate
Omega-Aminobutyric acid
Piperidate
Piperidic acid
Piperidinate
Piperidinic acid
gamma Aminobutyrate
gamma Aminobutyric acid
gamma-Aminobutyrate
gamma-Aminobutyric acid
w-Aminobutyrate
w-Aminobutyric acid

Interventional clinical trials:

idNameStatusNCT IDPhase
1Baclofen in the Treatment of Muscle Cramps in Patients With CirrhosisRecruitingNCT02221570

Search NIH Clinical Center for Chronic Hiccups

Genetic Tests for Chronic Hiccups

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Anatomical Context for Chronic Hiccups

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MalaCards organs/tissues related to Chronic Hiccups:

33
Brain, Spinal cord, Heart, Breast, Lung, Myeloid, Endothelial

Animal Models for Chronic Hiccups or affiliated genes

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Publications for Chronic Hiccups

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Articles related to Chronic Hiccups:

(show all 12)
idTitleAuthorsYear
1
A case of obstructive sleep apnea, gastroesophageal reflux disease, and chronic hiccups: will CPAP help? (23319912)
2013
2
Treatment of chronic hiccups in cancer patients: a systematic review. (22891647)
2012
3
General anesthesia or phrenic nerve block for treatment of chronic hiccups? (12598292)
2003
4
Severe respiratory depression by low-dose baclofen in the treatment of chronic hiccups in a patient undergoing CAPD. (11124626)
2000
5
Japanese electro-acustim in the treatment of chronic hiccups. (10201504)
1999
6
The use of baclofen for treatment of chronic hiccups. (10439566)
1999
7
Chronic hiccups following chemotherapy. (10641462)
1999
8
Korean hand acupuncture in the treatment of chronic hiccups. (9820436)
1998
9
Chronic hiccups and sleep. (8723381)
1996
10
Baclofen for chronic hiccups. (8858705)
1996
11
Chronic hiccups and gastroesophageal reflux disease: the acid perfusion test as a provocative maneuver. (3729205)
1986
12
Chronic hiccups. (3022571)
1986

Variations for Chronic Hiccups

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Expression for genes affiliated with Chronic Hiccups

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Search GEO for disease gene expression data for Chronic Hiccups.

Pathways for genes affiliated with Chronic Hiccups

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GO Terms for genes affiliated with Chronic Hiccups

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Sources for Chronic Hiccups

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet