MCID: CHR281
MIFTS: 25

Chronic Hiccups malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Chronic Hiccups

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NIH Rare Diseases:42 Chronic hiccups are hiccups that persist for a long period of time or recur frequently over an extended period of time. a hiccup is an unintentional movement (spasm) of the diaphragm, the muscle at the base of the lungs. the spasm is followed by the rapid closure of the vocal cords, which produces a distinctive sound. hiccups often start for no apparent reason and usually disappear after a few minutes. hiccups that last for more than two days and less than a month are sometimes called persistent or protracted hiccups. on rare occasions, hiccups persist even longer than a month or recur frequently over an extended period of time, and are called intractable hiccups. intractable hiccups are difficult to treat and often indicate the presence of another medical problem. last updated: 6/21/2013

MalaCards based summary: Chronic Hiccups, also known as intractable singultus, is related to hemangioblastoma and gastroesophageal reflux disease, and has symptoms including functional anomalies of the respiratory system and diaphragm, chronic hiccup and movement disorder. Affiliated tissues include lung and testes.

Aliases & Classifications for Chronic Hiccups

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Chronic Hiccups, Aliases & Descriptions:

Name: Chronic Hiccups 42
Intractable Singultus 42
Hiccups, Intractable 42
Intractable Hiccups 42
 
Persistent Hiccups 42
Chronic Hiccough 48
Chronic Hiccup 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
chronic hiccough:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Related Diseases for Chronic Hiccups

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Graphical network of the top 20 diseases related to Chronic Hiccups:



Diseases related to chronic hiccups

Symptoms for Chronic Hiccups

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Symptoms:

48 (show all 14)
  • functional anomalies of the respiratory system and diaphragm
  • chronic hiccup
  • movement disorder
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • angor pectoris/myocardial infarction
  • renal failure
  • diabetes insipidus
  • transient cerebral ischemia/stroke
  • sleep and vigilance disorders
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • fever/chilling
  • dehydration/hydroelectrolytic loss

HPO human phenotypes related to Chronic Hiccups:

(show all 11)
id Description Frequency HPO Source Accession
1 functional respiratory abnormality hallmark (90%) HP:0002795
2 abnormality of movement hallmark (90%) HP:0100022
3 recurrent singultus hallmark (90%) HP:0100247
4 renal insufficiency occasional (7.5%) HP:0000083
5 diabetes insipidus occasional (7.5%) HP:0000873
6 coronary artery disease occasional (7.5%) HP:0001677
7 dehydration occasional (7.5%) HP:0001944
8 sleep disturbance occasional (7.5%) HP:0002360
9 cerebral ischemia occasional (7.5%) HP:0002637
10 abnormality of temperature regulation occasional (7.5%) HP:0004370
11 neoplasm of the nervous system occasional (7.5%) HP:0004375

Drugs & Therapeutics for Chronic Hiccups

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Drug clinical trials:

Search ClinicalTrials for Chronic Hiccups

Search NIH Clinical Center for Chronic Hiccups

Genetic Tests for Chronic Hiccups

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Anatomical Context for Chronic Hiccups

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MalaCards organs/tissues related to Chronic Hiccups:

32
Lung, Testes

Animal Models for Chronic Hiccups or affiliated genes

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Publications for Chronic Hiccups

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Articles related to Chronic Hiccups:

(show all 12)
idTitleAuthorsYear
1
A case of obstructive sleep apnea, gastroesophageal reflux disease, and chronic hiccups: will CPAP help? (23319912)
2013
2
Treatment of chronic hiccups in cancer patients: a systematic review. (22891647)
2012
3
General anesthesia or phrenic nerve block for treatment of chronic hiccups? (12598292)
2003
4
Severe respiratory depression by low-dose baclofen in the treatment of chronic hiccups in a patient undergoing CAPD. (11124626)
2000
5
Japanese electro-acustim in the treatment of chronic hiccups. (10201504)
1999
6
The use of baclofen for treatment of chronic hiccups. (10439566)
1999
7
Chronic hiccups following chemotherapy. (10641462)
1999
8
Korean hand acupuncture in the treatment of chronic hiccups. (9820436)
1998
9
Chronic hiccups and sleep. (8723381)
1996
10
Baclofen for chronic hiccups. (8858705)
1996
11
Chronic hiccups and gastroesophageal reflux disease: the acid perfusion test as a provocative maneuver. (3729205)
1986
12
Chronic hiccups. (3022571)
1986

Variations for Chronic Hiccups

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Expression for genes affiliated with Chronic Hiccups

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Search GEO for disease gene expression data for Chronic Hiccups.

Pathways for genes affiliated with Chronic Hiccups

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Compounds for genes affiliated with Chronic Hiccups

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GO Terms for genes affiliated with Chronic Hiccups

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Products for genes affiliated with Chronic Hiccups

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  • Antibodies
  • Proteins
  • Lysates

Sources for Chronic Hiccups

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet