MCID: CHR281
MIFTS: 25

Chronic Hiccups malady

Rare diseases, Gastrointestinal diseases categories

Summaries for Chronic Hiccups

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NIH Rare Diseases:41 Chronic hiccups are unintentional movements (spasms) of the diaphragm followed by rapid closure of the vocal cords that persist for an extended period of time. hiccups often develop for no apparent reason and typically go away on their own after a couple minutes. however, chronic hiccups last over two days and in rare cases, may continue for over a month. hiccups that recur over long periods of time are also considered "chronic." depending on how long the hiccups last, affected people may become exhausted, dehydrated and/or lose weight due to interruptions in sleep and normal eating patterns. other complications may include irregular heart beat and gastroesophageal reflux. the exact underlying cause is often unknown; some cases may be caused by surgery, certain medications and/or a variety of health problems such as central nervous system (brain and spinal cord) abnormalities, psychological problems, conditions that irritate the diaphragm, and metabolic diseases. treatment of chronic hiccups varies but may include medications and/or surgery. last updated: 12/23/2014

MalaCards based summary: Chronic Hiccups, also known as chronic hiccough, is related to hemangioblastoma and neuromyelitis optica, and has symptoms including functional respiratory abnormality, abnormality of movement and recurrent singultus. Affiliated tissues include brain, spinal cord and heart.

Aliases & Classifications for Chronic Hiccups

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Chronic Hiccups, Aliases & Descriptions:

Name: Chronic Hiccups 41
Chronic Hiccough 41 47
Chronic Hiccup 41 47
Intractable Singultus 41
 
Hiccups, Intractable 41
Intractable Hiccups 41
Persistent Hiccups 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

47
chronic hiccough:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


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Related Diseases for Chronic Hiccups

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Graphical network of the top 20 diseases related to Chronic Hiccups:



Diseases related to chronic hiccups

Symptoms for Chronic Hiccups

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Symptoms:

 47 (show all 14)
  • functional anomalies of the respiratory system and diaphragm
  • chronic hiccup
  • movement disorder
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • angor pectoris/myocardial infarction
  • renal failure
  • diabetes insipidus
  • transient cerebral ischemia/stroke
  • sleep and vigilance disorders
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • fever/chilling
  • dehydration/hydroelectrolytic loss

HPO human phenotypes related to Chronic Hiccups:

(show all 11)
id Description Frequency HPO Source Accession
1 functional respiratory abnormality hallmark (90%) HP:0002795
2 abnormality of movement hallmark (90%) HP:0100022
3 recurrent singultus hallmark (90%) HP:0100247
4 renal insufficiency occasional (7.5%) HP:0000083
5 diabetes insipidus occasional (7.5%) HP:0000873
6 coronary artery disease occasional (7.5%) HP:0001677
7 dehydration occasional (7.5%) HP:0001944
8 sleep disturbance occasional (7.5%) HP:0002360
9 cerebral ischemia occasional (7.5%) HP:0002637
10 abnormality of temperature regulation occasional (7.5%) HP:0004370
11 neoplasm of the nervous system occasional (7.5%) HP:0004375

Drugs & Therapeutics for Chronic Hiccups

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Drug clinical trials:

Search ClinicalTrials for Chronic Hiccups

Search NIH Clinical Center for Chronic Hiccups

Genetic Tests for Chronic Hiccups

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Anatomical Context for Chronic Hiccups

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MalaCards organs/tissues related to Chronic Hiccups:

31
Brain, Spinal cord, Heart, Testes

Animal Models for Chronic Hiccups or affiliated genes

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Publications for Chronic Hiccups

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Articles related to Chronic Hiccups:

(show all 12)
idTitleAuthorsYear
1
A case of obstructive sleep apnea, gastroesophageal reflux disease, and chronic hiccups: will CPAP help? (23319912)
2013
2
Treatment of chronic hiccups in cancer patients: a systematic review. (22891647)
2012
3
General anesthesia or phrenic nerve block for treatment of chronic hiccups? (12598292)
2003
4
Severe respiratory depression by low-dose baclofen in the treatment of chronic hiccups in a patient undergoing CAPD. (11124626)
2000
5
Japanese electro-acustim in the treatment of chronic hiccups. (10201504)
1999
6
The use of baclofen for treatment of chronic hiccups. (10439566)
1999
7
Chronic hiccups following chemotherapy. (10641462)
1999
8
Korean hand acupuncture in the treatment of chronic hiccups. (9820436)
1998
9
Chronic hiccups and sleep. (8723381)
1996
10
Baclofen for chronic hiccups. (8858705)
1996
11
Chronic hiccups and gastroesophageal reflux disease: the acid perfusion test as a provocative maneuver. (3729205)
1986
12
Chronic hiccups. (3022571)
1986

Variations for Chronic Hiccups

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Expression for genes affiliated with Chronic Hiccups

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Search GEO for disease gene expression data for Chronic Hiccups.

Pathways for genes affiliated with Chronic Hiccups

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Compounds for genes affiliated with Chronic Hiccups

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GO Terms for genes affiliated with Chronic Hiccups

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Products for genes affiliated with Chronic Hiccups

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Chronic Hiccups

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet