MCID: CHR281
MIFTS: 22

Chronic Hiccups malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Chronic Hiccups

Aliases & Descriptions for Chronic Hiccups:

Name: Chronic Hiccups 50
Intractable Singultus 50
Hiccups, Intractable 50
Intractable Hiccups 50
Persistent Hiccups 50
Chronic Hiccough 56
Chronic Hiccup 56

Characteristics:

Orphanet epidemiological data:

56
chronic hiccup
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA396

Summaries for Chronic Hiccups

NIH Rare Diseases : 50 chronic hiccups are unintentional movements (spasms) of the diaphragm followed by rapid closure of the vocal cords that persist for an extended period of time. hiccups often develop for no apparent reason and typically go away on their own after a couple minutes. however, chronic hiccups last over two days and in rare cases, may continue for over a month. hiccups that recur over long periods of time are also considered "chronic." depending on how long the hiccups last, affected people may become exhausted, dehydrated and/or lose weight due to interruptions in sleep and normal eating patterns. other complications may include irregular heart beat and gastroesophageal reflux. the exact underlying cause is often unknown; some cases may be caused by surgery, certain medications and/or a variety of health problems such as central nervous system (brain and spinal cord) abnormalities, psychological problems, conditions that irritate the diaphragm, and metabolic diseases. treatment of chronic hiccups varies but may include medications and/or surgery. last updated: 12/23/2014

MalaCards based summary : Chronic Hiccups, also known as intractable singultus, is related to neuromyelitis optica and hemangioblastoma. The drugs Dopamine and Chlorpromazine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and spinal cord.

Related Diseases for Chronic Hiccups

Graphical network of the top 20 diseases related to Chronic Hiccups:



Diseases related to Chronic Hiccups

Symptoms & Phenotypes for Chronic Hiccups

Drugs & Therapeutics for Chronic Hiccups

Drugs for Chronic Hiccups (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 1 51-61-6, 62-31-7 681
2
Chlorpromazine Approved, Vet_approved Phase 1 50-53-3 2726
3 Neurotransmitter Agents Phase 1
4 Gastrointestinal Agents Phase 1
5 Tranquilizing Agents Phase 1
6 Peripheral Nervous System Agents Phase 1
7 Dopamine Agents Phase 1
8 Dopamine Antagonists Phase 1
9 Antiemetics Phase 1
10 Psychotropic Drugs Phase 1
11 Antipsychotic Agents Phase 1
12 Autonomic Agents Phase 1
13 Central Nervous System Depressants Phase 1
14
Baclofen Approved 1134-47-0 2284
15 GABA Agents
16
gamma-Aminobutyric Acid 56-12-2 119

Interventional clinical trials:


id Name Status NCT ID Phase
1 Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride Completed NCT02943213 Phase 1
2 Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis Unknown status NCT02221570

Search NIH Clinical Center for Chronic Hiccups

Genetic Tests for Chronic Hiccups

Anatomical Context for Chronic Hiccups

MalaCards organs/tissues related to Chronic Hiccups:

39
Heart, Brain, Spinal Cord, Testes

Publications for Chronic Hiccups

Articles related to Chronic Hiccups:

(show all 12)
id Title Authors Year
1
A case of obstructive sleep apnea, gastroesophageal reflux disease, and chronic hiccups: will CPAP help? ( 23319912 )
2013
2
Treatment of chronic hiccups in cancer patients: a systematic review. ( 22891647 )
2012
3
General anesthesia or phrenic nerve block for treatment of chronic hiccups? ( 12598292 )
2003
4
Severe respiratory depression by low-dose baclofen in the treatment of chronic hiccups in a patient undergoing CAPD. ( 11124626 )
2000
5
Japanese electro-acustim in the treatment of chronic hiccups. ( 10201504 )
1999
6
The use of baclofen for treatment of chronic hiccups. ( 10439566 )
1999
7
Chronic hiccups following chemotherapy. ( 10641462 )
1999
8
Korean hand acupuncture in the treatment of chronic hiccups. ( 9820436 )
1998
9
Chronic hiccups and sleep. ( 8723381 )
1996
10
Baclofen for chronic hiccups. ( 8858705 )
1996
11
Chronic hiccups. ( 3022571 )
1986
12
Chronic hiccups and gastroesophageal reflux disease: the acid perfusion test as a provocative maneuver. ( 3729205 )
1986

Variations for Chronic Hiccups

Expression for Chronic Hiccups

Search GEO for disease gene expression data for Chronic Hiccups.

Pathways for Chronic Hiccups

GO Terms for Chronic Hiccups

Sources for Chronic Hiccups

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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