MCID: CHR281
MIFTS: 23

Chronic Hiccups

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Chronic Hiccups

MalaCards integrated aliases for Chronic Hiccups:

Name: Chronic Hiccups 49
Intractable Singultus 49
Hiccups, Intractable 49
Intractable Hiccups 49
Persistent Hiccups 49
Chronic Hiccup 55

Characteristics:

Orphanet epidemiological data:

55
chronic hiccup
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Orphanet 55 ORPHA396

Summaries for Chronic Hiccups

NIH Rare Diseases : 49 Chronic hiccups are unintentional movements (spasms) of the diaphragm followed by rapid closure of the vocal cords that persist for an extended period of time. Hiccups often develop for no apparent reason and typically go away on their own after a couple minutes. However, chronic hiccups last over two days and in rare cases, may continue for over a month. Hiccups that recur over long periods of time are also considered "chronic." Depending on how long the hiccups last, affected people may become exhausted, dehydrated and/or lose weight due to interruptions in sleep and normal eating patterns. Other complications may include irregular heart beat and gastroesophageal reflux. The exact underlying cause is often unknown; some cases may be caused by surgery, certain medications and/or a variety of health problems such as central nervous system (brain and spinal cord) abnormalities, psychological problems, conditions that irritate the diaphragm, and metabolic diseases. Treatment of chronic hiccups varies but may include medications and/or surgery. Last updated: 12/23/2014

MalaCards based summary : Chronic Hiccups, also known as intractable singultus, is related to neuromyelitis optica and hemangioblastoma. The drugs Dopamine and Chlorpromazine have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and brain.

Related Diseases for Chronic Hiccups

Diseases related to Chronic Hiccups via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 neuromyelitis optica 10.0
2 hemangioblastoma 10.0
3 gastroesophageal reflux 9.9
4 systemic lupus erythematosus 9.8
5 myocardial infarction 9.8
6 hemangioma 9.8
7 arteriovenous malformation 9.8
8 esophagitis 9.8
9 aseptic meningitis 9.8
10 astrocytoma 9.8
11 demyelinating disease 9.8
12 syringomyelia 9.8
13 laryngitis 9.8
14 gastritis 9.8
15 cavernous hemangioma 9.8
16 pilocytic astrocytoma 9.8
17 herpes zoster 9.8
18 lupus erythematosus 9.8
19 meningitis 9.8
20 neuromyelitis optica spectrum disorder 9.8
21 syringobulbia 9.8
22 cavernous malformation 9.8
23 dysphagia 9.8
24 pheochromocytoma 9.7
25 apnea, obstructive sleep 9.7
26 sleep apnea 9.7
27 aneurysm 9.7

Graphical network of the top 20 diseases related to Chronic Hiccups:



Diseases related to Chronic Hiccups

Symptoms & Phenotypes for Chronic Hiccups

Drugs & Therapeutics for Chronic Hiccups

Drugs for Chronic Hiccups (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 1 51-61-6, 62-31-7 681
2
Chlorpromazine Approved, Investigational, Vet_approved Phase 1 50-53-3 2726
3 Neurotransmitter Agents Phase 1
4 Central Nervous System Depressants Phase 1
5 Gastrointestinal Agents Phase 1
6 Tranquilizing Agents Phase 1
7 Dopamine Agents Phase 1
8 Dopamine Antagonists Phase 1
9 Peripheral Nervous System Agents Phase 1
10 Antiemetics Phase 1
11 Psychotropic Drugs Phase 1
12 Antipsychotic Agents Phase 1
13 Autonomic Agents Phase 1
14
Baclofen Approved 1134-47-0 2284
15
gamma-Aminobutyric acid Approved, Investigational 56-12-2 119
16 GABA Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride Completed NCT02943213 Phase 1 Chlorpromazine Hydrochloride
2 Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis Unknown status NCT02221570 Baclofen

Search NIH Clinical Center for Chronic Hiccups

Genetic Tests for Chronic Hiccups

Anatomical Context for Chronic Hiccups

MalaCards organs/tissues related to Chronic Hiccups:

38
Heart, Spinal Cord, Brain, Testes

Publications for Chronic Hiccups

Articles related to Chronic Hiccups:

(show all 14)
# Title Authors Year
1
Chronic Hiccups: An Underestimated Problem. ( 28759492 )
2017
2
Huge left atrial appendage aneurysm revealed by chronic hiccups. ( 28983173 )
2017
3
A case of obstructive sleep apnea, gastroesophageal reflux disease, and chronic hiccups: will CPAP help? ( 23319912 )
2013
4
Treatment of chronic hiccups in cancer patients: a systematic review. ( 22891647 )
2012
5
General anesthesia or phrenic nerve block for treatment of chronic hiccups? ( 12598292 )
2003
6
Severe respiratory depression by low-dose baclofen in the treatment of chronic hiccups in a patient undergoing CAPD. ( 11124626 )
2000
7
Chronic hiccups following chemotherapy. ( 10641462 )
1999
8
The use of baclofen for treatment of chronic hiccups. ( 10439566 )
1999
9
Japanese electro-acustim in the treatment of chronic hiccups. ( 10201504 )
1999
10
Korean hand acupuncture in the treatment of chronic hiccups. ( 9820436 )
1998
11
Baclofen for chronic hiccups. ( 8858705 )
1996
12
Chronic hiccups and sleep. ( 8723381 )
1996
13
Chronic hiccups. ( 3022571 )
1986
14
Chronic hiccups and gastroesophageal reflux disease: the acid perfusion test as a provocative maneuver. ( 3729205 )
1986

Variations for Chronic Hiccups

Expression for Chronic Hiccups

Search GEO for disease gene expression data for Chronic Hiccups.

Pathways for Chronic Hiccups

GO Terms for Chronic Hiccups

Sources for Chronic Hiccups

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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