CIDP
MCID: CHR283
MIFTS: 45

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) malady

Neuronal diseases category

Summaries for Chronic Inflammatory Demyelinating Polyneuropathy

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42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. The disorder, which is sometimes called chronic relapsing polyneuropathy, is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves. Although it can occur at any age and in both genders, CIDP is more common in young adults, and in men more so than women. It often presents with symptoms that include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes (areflexia), fatigue, and abnormal sensations. CIDP is closely related to Guillain-Barre syndrome and it is considered the chronic counterpart of that acute disease.

MalaCards: Chronic Inflammatory Demyelinating Polyneuropathy, also known as CIDP, is related to demyelinating polyneuropathy and polyneuropathy. An important gene associated with Chronic Inflammatory Demyelinating Polyneuropathy is AIF1 (allograft inflammatory factor 1), and among its related pathways are Axonal growth inhibition (RHOA activation) and Hematopoietic cell lineage. The drug immunoglobulins, intravenous and the compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

NIH Rare Diseases:42 Chronic inflammatory demyelinating polyneuropathy (cidp) is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. the disorder is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves. it often presents with symptoms that include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes, fatigue, and abnormal sensations. cidp is closely related to guillain-barre syndrome and it is considered the chronic counterpart of that acute disease. treatment may include corticosteroids, immunosuppressant drugs, plasma exchange, physiotherapy, and/or intravenous immunoglobulin (ivig) therapy. last updated: 8/1/2012

Wikipedia:63 Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory... more...

Aliases & Classifications for Chronic Inflammatory Demyelinating Polyneuropathy

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48Orphanet, 42NIH Rare Diseases, 43NINDS, 30LifeMap Discovery™, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
chronic inflammatory demyelinating polyneuropathy:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

chronic inflammatory demyelinating polyneuropathy 42 43 48 30
cidp 42 48
polyradiculoneuropathy, chronic inflammatory demyelinating 60
chronic inflammatory demyelinating polyradiculoneuropathy 48


External Ids:

ICD10 via Orphanet26 G61.8
SNOMED-CT via Orphanet57 128209004

Related Diseases for Chronic Inflammatory Demyelinating Polyneuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Chronic Inflammatory Demyelinating Polyneuropathy family:

Demyelinating Polyneuropathy Subacute Inflammatory Demyelinating Polyneuropathy

Diseases related to Chronic Inflammatory Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1demyelinating polyneuropathy32.3CNTN2
2polyneuropathy32.3TUBB, IFNA2, MAG, CNTF, CD28, GDNF
3neuropathy31.3NGF, MAG
4diabetic polyneuropathy31.2NGF
5myasthenia gravis30.9CTLA4, AIRE, MAG, CD28
6diabetes mellitus30.9AIRE, CTLA4, TNF, NGF
7melanoma30.8CTLA4, IFNA2, CSF1, CXCL9, IFNA1, TNF
8hepatitis30.8IFNA2, CTLA4, AIRE, IFNA1
9multiple sclerosis30.8CXCL9, IFNA1, CSF1, TNF, CTLA4, MAG
10lupus erythematosus30.6FCGR2B
11myopathy30.6NGF
12glomerulonephritis30.6CXCL9, CD28, GAS6
13hepatitis b30.6CTLA4, IFNA2, IFNA1
14arthritis30.6FCGR2B, CTLA4, CSF1, TNF, CXCL9
15hepatitis c30.6TNF, CTLA4, IFNA2, CD28, IFNA1
16systemic lupus erythematosus30.6FCGR2B, IFNA1, TNF, CTLA4, CD28
17meningitis30.4GDNF
18crohn's disease30.4TNF
19graft versus host disease30.4TNF, CTLA4, CD28
20alopecia30.4AIRE
21peritonitis30.4TNF
22pneumonia30.4TNF
23macroglobulinemia30.4MAG
24guillain-barre syndrome30.4TUBB
25dermatitis30.4CTLA4, CXCL9
26thyroiditis30.4CTLA4, IFNA1
27diabetic neuropathy30.3NGF, CNTF, GDNF
28influenza30.3IFNA1, CD28, CXCL9
29hepatocellular carcinoma30.3CTLA4, IFNA2, IFNA1, CXCL9
30thrombocytopenia30.3IFNA2, IFNA1, CSF1, FCGR2B
31connective tissue disease30.3IFNA1, FCGR2B, CTLA4, TNF
32amyotrophic lateral sclerosis30.3CSF1, NGF, MAG, GDNF, CNTF
33psoriasis30.3CXCL9, TNF, CTLA4, NGF, CD28
34rheumatoid arthritis30.3CSF1, TNF, CTLA4, CNTN2, CD1D, CD28
35leukemia30.3IFNA2, GDNF, TNF, GAS6, CNTN2, CSF1
36neuritis29.8AIF1
37sarcoma29.8CSF1
38myeloma29.8CSF1, CNTF, MAG, IFNA1, CD28, IFNA2
39chronic polyneuropathy11.6
40poems syndrome10.5
41charcot-marie-tooth disease10.5
42respiratory failure10.5
43tooth disease10.5
44polyradiculoneuropathy10.5
45chronic inflammatory demyelinating polyradiculoneuropathy10.4
46mononeuritis multiplex10.4
47carpal tunnel syndrome10.4
48neuronitis10.4
49hypertension10.4
50intracranial hypertension10.4

Graphical network of the top 20 diseases related to Chronic Inflammatory Demyelinating Polyneuropathy:



Diseases related to chronic inflammatory demyelinating polyneuropathy

Clinical Features for Chronic Inflammatory Demyelinating Polyneuropathy

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Drugs & Therapeutics for Chronic Inflammatory Demyelinating Polyneuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Inflammatory Demyelinating Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Chronic Inflammatory Demyelinating Polyneuropathy

Search NIH Clinical Center for Chronic Inflammatory Demyelinating Polyneuropathy

Search CenterWatch for Chronic Inflammatory Demyelinating Polyneuropathy

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Chronic Inflammatory Demyelinating Polyneuropathy:
Hematopoietic stem cells for treatment of chronic inflammatory demyelinating polyneuropathy
Embryonic/Adult Cultured Cells Related to Chronic Inflammatory Demyelinating Polyneuropathy:
Bone marrow-derived hematopoietic stem cells, PMID: 17277794

Genetic Tests for Chronic Inflammatory Demyelinating Polyneuropathy

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Anatomical Context for Chronic Inflammatory Demyelinating Polyneuropathy

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Sources:
32MalaCards
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MalaCards organs/tissues related to Chronic Inflammatory Demyelinating Polyneuropathy:

32
Bone

Animal Models for Chronic Inflammatory Demyelinating Polyneuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chronic Inflammatory Demyelinating Polyneuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.4CSF1, TNF, GDNF, FCGR2B
2MP:00053709.3FCGR2B, CD1D, AIRE, CTLA4, TNF, CSF1
3MP:00036318.6CNTN2, MAG, AIRE, CSF1, CNTF, CD1D
4MP:00053858.5GAS6, CTLA4, TNF, CSF1, NGF, CD1D
5MP:00053978.4GAS6, CTLA4, TNF, CSF1, AIRE, CNTF
6MP:00053768.4GAS6, CTLA4, TNF, CSF1, AIRE, CNTF
7MP:00053868.4MAG, AIRE, TNF, CSF1, CNTN2, CNTF
8MP:00107688.3GAS6, CTLA4, TNF, CSF1, AIRE, NGF
9MP:00053848.3GAS6, CTLA4, TNF, CSF1, AIRE, CNTF
10MP:00053878.2FCGR2B, CSF1, TNF, CTLA4, GAS6, AIRE

Publications for Chronic Inflammatory Demyelinating Polyneuropathy

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Genetic Variations for Chronic Inflammatory Demyelinating Polyneuropathy

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Expression for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

Search GEO for disease gene expression data for Chronic Inflammatory Demyelinating Polyneuropathy.

Pathways for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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Sources:
53Reactome, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0MAG, NGF
29.8CD1D, TNF, CSF1
3
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9.8IFNA2, IFNA1, TNF
49.8TNF, IFNA1, IFNA2
59.7TNF, AIF1, MAG, GDNF
6
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9.6FCGR2B, TNF, IFNA1, IFNA2
79.6FCGR2B, TNF, IFNA1, IFNA2
89.6CD28, CTLA4, TNF, CSF1
99.5IFNA2, IFNA1, TNF, CLDN5
10
Hide members
9.5IFNA2, IFNA1, TNF, CXCL9
11
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9.4CSF1, TNF, GAS6, CD28, CXCL9
12
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9.4CSF1, TNF, GAS6, CD28, CXCL9
139.3CTLA4, MAG, CNTN2, CD28, CLDN5
14
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9.3FCGR2B, CD28, TNF, IFNA1, IFNA2
15
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9.3TNF, CTLA4, CD28, FYB, FCGR2B
16
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9.3CD28, CTLA4, TNF, IFNA1, IFNA2
17
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8.7CXCL9, IFNA2, IFNA1, CSF1, TNF, CNTF

Compounds for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.3IFNA1
2estrogen4410.3CNTN2, FCGR2B
3pegasys4410.2IFNA1, IFNA2
4etanercept44 49 1112.1FCGR2B, IFNA2, CSF1, TNF
5superoxide44 2411.1CNTF, IFNA2, FCGR2B, TNF
6imiquimod44 28 59 1113.0IFNA2, IFNA1, TNF
7bromodeoxyuridine4410.0CNTN2, CNTF, TUBB, AIF1, GDNF
8ivig4410.0TNF, MAG, FCGR2B, CSF1
9il 104410.0CSF1, CTLA4, CXCL9, TNF
10rantes4410.0GDNF, TNF, CSF1, IFNA1
11bcnu4410.0IFNA2, IFNA1, CSF1
12zidovudine44 1110.9CSF1, IFNA1, IFNA2, CNTN2
13dexamethasone44 49 28 1112.9IFNA1, CXCL9, GDNF, CTLA4
14neopterin449.9CSF1, IFNA1, IFNA2, TNF
15ifn-alpha449.9CSF1, IFNA2, IFNA1, CXCL9
16thalidomide44 49 59 1112.9IFNA1, CTLA4, TNF, IFNA2
17ganglioside449.9CTLA4, MAG, CNTF, NGF, GDNF
1812-o-tetradecanoylphorbol 13-acetate449.9CSF1, NGF, CNTN2, IFNA2, CNTF
19cytarabine44 49 1111.8IFNA1, CSF1, IFNA2, NGF
20acetylcholine44 49 28 11 2413.8MAG, CTLA4, GDNF, NGF, CNTF
21prednisolone44 28 1111.8IFNA1, IFNA2, CSF1, TNF, NGF
22choline44 11 2411.8CNTF, CNTN2, NGF, GDNF
23con a449.7CD28, CTLA4, IFNA2
24ceramide449.7CNTN2, TNF, CD1D, NGF, CD28
25retinoid449.7CNTN2, CD1D, IFNA2, IFNA1, CSF1
26cyclic amp44 2410.6CNTF, MAG, CNTN2, GDNF, CD28
27tacrolimus44 49 1111.6GDNF, IFNA1, TNF, CD28, CTLA4
28ionomycin449.6TNF, CXCL9, CSF1, CD28, CNTN2, CTLA4
29actinomycin d449.6IFNA1, TNF, CNTF, NGF, CSF1, GDNF
30histamine44 28 2411.5IFNA2, TNF, NGF, CXCL9, FCGR2B, CNTF
31wortmannin449.5CNTF, GAS6, CD28, GDNF, NGF, CSF1
32pd 98,059449.5NGF, CNTF, TNF, CSF1, GDNF
33serine449.5TNF, GDNF, CSF1, MAG, CTLA4, FCGR2B
34genistein44 28 59 2 11 2414.5FCGR2B, CD28, GDNF, NGF, CNTF, CSF1
35cyclosporin a44 28 5911.4NGF, CTLA4, TNF, IFNA1, CD28, CNTN2
36phosphotyrosine449.4MAG, TUBB, CSF1, CD28, NGF, FYB
37h2o2449.4GDNF, CNTF, TNF, CSF1, CNTN2, TUBB
38rituximab44 49 1111.4CSF1, IFNA2, TNF, IFNA1, CTLA4, MAG
39tgf beta1449.4GDNF, CTLA4, CSF1, TNF
40ly294002449.3CSF1, TNF, CNTF, CTLA4, GAS6, NGF
41threonine449.3CD28, NGF, CNTN2, MAG, CNTF, CTLA4
42cysteine449.0CSF1, MAG, IFNA2, CD28, TUBB, GDNF
43retinoic acid44 249.9CNTF, AIF1, TNF, NGF, CD1D, GDNF
44phosphatidylinositol448.9CTLA4, GAS6, CSF1, CNTF, NGF, CD28
45vegf448.9NGF, IFNA2, CXCL9, GDNF, CNTF, CNTN2
46alanine448.9IFNA2, IFNA1, CSF1, CTLA4, MAG, NGF
47lipid448.8TNF, GDNF, FCGR2B, TUBB, CD28, CD1D
48thymidine44 249.7CTLA4, IFNA2, IFNA1, FCGR2B, NGF, CNTN2
49calcium44 49 11 2411.3CXCL9, FCGR2B, CLDN5, CD28, GDNF, AIF1
50tyrosine447.6NGF, AIRE, FCGR2B, FYB, CXCL9, GDNF

GO Terms for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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16Gene Ontology
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Cellular components related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.1AIF1, TNF
2paranode region of axonGO:03327010.0CLDN5, MAG
3Schmidt-Lanterman incisureGO:0432209.9MAG, CLDN5
4external side of plasma membraneGO:0098979.6TNF, CTLA4, CD28, CXCL9
5extracellular spaceGO:0056159.2CXCL9, NGF, CNTF, GAS6, TNF, CSF1
6plasma membraneGO:0058868.1TUBB, CSF1, TNF, CTLA4, AIRE, MAG

Biological processes related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.9GDNF, NGF, CNTF
2humoral immune responseGO:0069599.8TNF, AIRE, CD28
3positive regulation of T cell proliferationGO:0421029.7CD28, CD1D, AIF1
4immune responseGO:0069559.5CTLA4, AIRE, CXCL9, FYB, FCGR2B
5inflammatory responseGO:0069549.4CXCL9, NGF, AIF1, TNF, CSF1, IFNA2
6signal transductionGO:0071659.0GAS6, CNTF, GDNF, CXCL9, FYB, FCGR2B

Molecular functions related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.6GDNF, NGF, CNTF, CSF1
2identical protein bindingGO:0428029.4CLDN5, CD28, CNTN2, AIRE, TNF
3cytokine activityGO:0051259.4IFNA2, CSF1, TNF, CXCL9

Products for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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  • Antibodies
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  • Antibodies

Sources for Chronic Inflammatory Demyelinating Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet