CIDP
MCID: CHR283
MIFTS: 54

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) malady

Neuronal category

Summaries for Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. The disorder, which is sometimes called chronic relapsing polyneuropathy, is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves. Although it can occur at any age and in both genders, CIDP is more common in young adults, and in men more so than women. It often presents with symptoms that include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes (areflexia), fatigue, and abnormal sensations. CIDP is closely related to Guillain-Barre syndrome and it is considered the chronic counterpart of that acute disease.

MalaCards: Chronic Inflammatory Demyelinating Polyneuropathy, also known as CIDP, is related to diabetic polyneuropathy and hepatitis d. An important gene associated with Chronic Inflammatory Demyelinating Polyneuropathy is AIF1 (allograft inflammatory factor 1), and among its related pathways are Axonal growth inhibition (RHOA activation) and Hematopoietic cell lineage. The drug immunoglobulins, intravenous and the compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and spinal cord, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

NIH Rare Diseases:43 Chronic inflammatory demyelinating polyneuropathy (cidp) is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. the disorder is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves. it often presents with symptoms that include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes, fatigue, and abnormal sensations. cidp is closely related to guillain-barre syndrome and it is considered the chronic counterpart of that acute disease. treatment may include corticosteroids, immunosuppressant drugs, plasma exchange, physiotherapy, and/or intravenous immunoglobulin (ivig) therapy. last updated: 8/1/2012

Wikipedia:64 Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory... more...

Aliases & Classifications for Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
49Orphanet, 43NIH Rare Diseases, 44NINDS, 31LifeMap Discovery™, 61UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
chronic inflammatory demyelinating polyneuropathy:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

chronic inflammatory demyelinating polyneuropathy 43 44 49 31
cidp 43 49
polyradiculoneuropathy, chronic inflammatory demyelinating 61
chronic inflammatory demyelinating polyradiculoneuropathy 49


External Ids:

ICD10 via Orphanet26 G61.8

Related Diseases for Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Chronic Inflammatory Demyelinating Polyneuropathy family:

demyelinating polyneuropathy subacute inflammatory demyelinating polyneuropathy

Diseases related to Chronic Inflammatory Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy31.0NGF
2hepatitis d30.8IFNA1, IFNA2
3hepatitis c30.8TNF, CTLA4, IFNA2, CD28, IFNA1
4arthritis30.6FCGR2B, CTLA4, CSF1, TNF, CXCL9
5systemic lupus erythematosus30.6FCGR2B, IFNA1, TNF, CTLA4, CD28
6graft versus host disease30.5TNF, CTLA4, CD28
7alopecia30.4AIRE
8macroglobulinemia30.4MAG
9thyroiditis30.4CTLA4, IFNA1
10thrombocytopenia30.4IFNA2, IFNA1, CSF1, FCGR2B
11amyotrophic lateral sclerosis30.4CSF1, NGF, MAG, GDNF, CNTF
12chronic inflammatory demyelinating polyradiculoneuropathy11.5
13guillain-barr� syndrome10.9
14neuropathy, inflammatory demyelinating10.9
15n syndrome10.6
16poems syndrome10.5
17tooth disease10.5
18multifocal motor neuropathy10.5
19autonomic dysfunction10.5
20mononeuritis multiplex10.4
21carpal tunnel syndrome10.4
22hepatitis a10.4
23tuberculosis10.4
24amyloid neuropathy10.4
25chronic pain10.4
26neurofibromatosis10.3
27evans' syndrome10.3
28radiculopathy10.3
29aseptic meningitis10.3
30cauda equina syndrome10.3
31arthropathy10.3
32neurologic diseases10.3
33castleman's disease10.3
34chronic graft versus host disease10.3
35encephalomyopathy10.3
36ataxia10.3
37myokymia10.3
38lewis-sumner syndrome10.3
39hematopoietic stem cell transplantation10.3
40marfan syndrome10.3
41membranous glomerulonephritis10.3
42focal segmental glomerulosclerosis10.3
43pulmonary tuberculosis10.3
44lateral sclerosis10.3
45granulomatous dermatitis10.3
46hepatitis e10.3
47mixed connective tissue disease10.3
48primary biliary cirrhosis10.3
49hypoparathyroidism10.3
50restless legs syndrome10.3

Graphical network of the top 20 diseases related to Chronic Inflammatory Demyelinating Polyneuropathy:



Diseases related to chronic inflammatory demyelinating polyneuropathy

Clinical Features for Chronic Inflammatory Demyelinating Polyneuropathy

Drugs & Therapeutics for Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Inflammatory Demyelinating Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Chronic Inflammatory Demyelinating Polyneuropathy

Search NIH Clinical Center for Chronic Inflammatory Demyelinating Polyneuropathy

Search CenterWatch for Chronic Inflammatory Demyelinating Polyneuropathy

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Chronic Inflammatory Demyelinating Polyneuropathy:
Hematopoietic stem cells for treatment of chronic inflammatory demyelinating polyneuropathy
Embryonic/Adult Cultured Cells Related to Chronic Inflammatory Demyelinating Polyneuropathy:
Bone marrow-derived hematopoietic stem cells, PMID: 17277794

Genetic Tests for Chronic Inflammatory Demyelinating Polyneuropathy

Anatomical Context for Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Chronic Inflammatory Demyelinating Polyneuropathy:

33
Bone marrow, Brain, Spinal cord, Liver, Thyroid, Skin, Nk cells, T cells, B cells, Endothelial, Dorsal root ganglion, Trigeminal ganglion

Animal Models for Chronic Inflammatory Demyelinating Polyneuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
51PubMed
See all sources

Articles related to Chronic Inflammatory Demyelinating Polyneuropathy:

(show top 50)    (show all 429)
idTitleAuthorsYear
1
Distal acquired demyelinating symmetric polyneuropathy progressing to classic chronic inflammatory demyelinating polyneuropathy and response to fludarabine and cyclophosphamide. (23168526)
2013
2
Antibodies to contactin-1 in chronic inflammatory demyelinating polyneuropathy. (23280477)
2013
3
Long-term outcome in chronic inflammatory demyelinating polyneuropathy patients treated with intravenous immunoglobulin: a retrospective study. (23512566)
2013
4
Chronic inflammatory demyelinating polyneuropathy following malignant melanoma. (22465895)
2012
5
Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy. (22462668)
2012
6
Diagnostic and therapeutic challenges in chronic inflammatory demyelinating polyneuropathy and other immune-mediated neuropathies. (21157311)
2011
7
Modulatory effects on axonal function after intravenous immunoglobulin therapy in chronic inflammatory demyelinating polyneuropathy. (21747028)
2011
8
Coexistence of two chronic neuropathies in a young child: Charcot-Marie-Tooth disease type 1A and chronic inflammatory demyelinating polyneuropathy. (20878740)
2010
9
Long-term regular plasmapheresis as a maintenance treatment for chronic inflammatory demyelinating polyneuropathy. (20626778)
2010
10
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (19915301)
2009
11
Chronic inflammatory demyelinating polyneuropathy associated with metastatic malignant melanoma of unknown primary origin. (19266164)
2009
12
Demyelinating findings in typical and atypical chronic inflammatory demyelinating polyneuropathy: sensitivity and specificity. (19494726)
2009
13
Early neurophysiological evolution of chronic inflammatory demyelinating polyneuropathy in a patient with Hashimoto's thyroiditis. (18932195)
2008
14
Electrophysiological predictors of steroid-responsiveness in chronic inflammatory demyelinating polyneuropathy. (18438699)
2008
15
A subset of fibromyalgia patients have findings suggestive of chronic inflammatory demyelinating polyneuropathy and appear to respond to IVIg. (18208823)
2008
16
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy. (17306302)
2007
17
Chronic inflammatory demyelinating polyneuropathy: a 6-year retrospective clinical study of a hospital-based population. (17258131)
2007
18
Analysing the favourable effects of physical exercise: relationships between physical fitness, fatigue and functioning in Guillain-BarrAc syndrome and chronic inflammatory demyelinating polyneuropathy. (17351693)
2007
19
Chronic inflammatory demyelinating polyneuropathy in an HCV-related cirrhotic patient with acute hepatitis B superinfection. (17449405)
2007
20
Dispersion of compound muscle action potential in hereditary neuropathies and chronic inflammatory demyelinating polyneuropathy. (16823858)
2006
21
The occurrence of carpal tunnel syndrome in chronic inflammatory demyelinating polyneuropathy. (16029960)
2005
22
Optimizing the use of electrophysiology in the diagnosis of chronic inflammatory demyelinating polyneuropathy: a study of 20 cases. (16221287)
2005
23
Treatment of refractory chronic inflammatory demyelinating polyneuropathy with interferon beta 1B. (15944862)
2005
24
AMSAN variant of Guillain Barre syndrome progressing to chronic inflammatory demyelinating polyneuropathy in a patient with Marfan's syndrome and pulmonary tuberculosis. (16515122)
2005
25
Interferon beta-1a in chronic inflammatory demyelinating polyneuropathy: case report. (15476092)
2004
26
Acute myocardial infarction following intravenous immunoglobulin therapy for chronic inflammatory demyelinating polyneuropathy in association with a monoclonal immunoglobulin G paraprotein. (14639034)
2004
27
A prospective evaluation of phrenic nerve conduction in multifocal motor neuropathy and chronic inflammatory demyelinating polyneuropathy. (12929191)
2003
28
Diagnostic value of nerve biopsy for atypical chronic inflammatory demyelinating polyneuropathy: evaluation of eight cases. (12661050)
2003
29
88th ENMC international workshop: childhood chronic inflammatory demyelinating polyneuropathy (including revised diagnostic criteria), Naarden, The Netherlands, December 8-10, 2000. (11738363)
2002
30
Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy. (12370473)
2002
31
Clinical and magnetic resonance imaging evidence of brain and spinal cord demyelination in a case of chronic inflammatory demyelinating polyneuropathy. (11437170)
2001
32
Chronic inflammatory demyelinating polyneuropathy and membranous glomerulonephropathy: report of two cases. (19078657)
2001
33
Chronic inflammatory demyelinating polyneuropathy in childhood. (11301217)
2001
34
Childhood chronic inflammatory demyelinating polyneuropathy: clinical course and long-term outcome. (10899445)
2000
35
Chronic inflammatory demyelinating polyneuropathy with papillodema and response to immunoglobulins. (24276666)
2000
36
Matrix metalloproteinase upregulation in chronic inflammatory demyelinating polyneuropathy and nonsystemic vasculitic neuropathy. (10408538)
1999
37
The diagnostic value of sural nerve T cells in chronic inflammatory demyelinating polyneuropathy. (10489051)
1999
38
Chronic inflammatory demyelinating polyneuropathy (CIDP) associated with seminoma. (9476725)
1998
39
Treatment of chronic inflammatory demyelinating polyneuropathy with interferon-alpha 2a. (9443462)
1998
40
Chronic inflammatory demyelinating polyneuropathy accompanied by carcinoma. (9728965)
1998
41
Prominent effect of immunoadsorption plasmapheresis therapy in a patient with chronic inflammatory demyelinating polyneuropathy associated with hepatitis B infection. (10227761)
1998
42
Micturitional disturbance in patients with chronic inflammatory demyelinating polyneuropathy. (9566423)
1998
43
Anti-beta-tubulin antibodies have no diagnostic value in patients with chronic inflammatory demyelinating polyneuropathy. (8551323)
1995
44
Chronic inflammatory demyelinating polyneuropathy mimicking a lumbar spinal stenosis syndrome. (7629539)
1995
45
Interferon-alpha may benefit steroid unresponsive chronic inflammatory demyelinating polyneuropathy. (7745420)
1995
46
Intravenous immunoglobulin therapy for chronic inflammatory demyelinating polyneuropathy recalcitrant to conventional therapy. (1948229)
1991
47
Intravenous immunoglobulin treatment in patients with chronic inflammatory demyelinating polyneuropathy. Clinical and laboratory characteristics associated with improvement. (1847041)
1991
48
Involvement of the central nervous system in chronic inflammatory demyelinating polyneuropathy: a clinical, electrophysiological and magnetic resonance imaging study. (2174078)
1990
49
Chronic inflammatory demyelinating polyneuropathy. (4086221)
1985
50
Apheresis in chronic inflammatory demyelinating polyneuropathy and in renal transplantation. Health and Public Policy Committee, American College of Physicians. (3898956)
1985

Genetic Variations for Chronic Inflammatory Demyelinating Polyneuropathy

Expression for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

Search GEO for disease gene expression data for Chronic Inflammatory Demyelinating Polyneuropathy.

Pathways for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
54Reactome, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Pathways related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0NGF, MAG
29.8CSF1, TNF, CD1D
3
Hide members
9.8TNF, IFNA1, IFNA2
49.8IFNA1, IFNA2, TNF
59.7TNF, GDNF, MAG, AIF1
6
Hide members
9.6FCGR2B, IFNA1, IFNA2, TNF
79.6TNF, IFNA1, IFNA2, FCGR2B
89.6CD28, CTLA4, TNF, CSF1
99.5IFNA2, CLDN5, IFNA1, TNF
10
Hide members
9.5TNF, IFNA2, IFNA1, CXCL9
11
Hide members
9.4CXCL9, CD28, GAS6, TNF, CSF1
12
Hide members
9.4CXCL9, CD28, CSF1, TNF, GAS6
139.3CLDN5, CTLA4, MAG, CD28, CNTN2
14
Hide members
9.3TNF, IFNA1, IFNA2, CD28, FCGR2B
15
Hide members
9.3FYB, CD28, CTLA4, TNF, FCGR2B
16
Hide members
9.3CTLA4, TNF, IFNA1, IFNA2, CD28
17
Hide members
8.7GDNF, IFNA2, IFNA1, CXCL9, CSF1, TNF

Compounds for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.3IFNA1
2estrogen4510.3CNTN2, FCGR2B
3pegasys4510.2IFNA1, IFNA2
4etanercept45 50 1112.1FCGR2B, IFNA2, CSF1, TNF
5superoxide45 2411.1CNTF, IFNA2, FCGR2B, TNF
6imiquimod45 29 60 1113.0IFNA2, IFNA1, TNF
7bromodeoxyuridine4510.0CNTN2, CNTF, TUBB, AIF1, GDNF
8ivig4510.0TNF, MAG, FCGR2B, CSF1
9il 104510.0CSF1, CTLA4, CXCL9, TNF
10rantes4510.0GDNF, TNF, CSF1, IFNA1
11bcnu4510.0IFNA2, IFNA1, CSF1
12zidovudine45 1110.9CSF1, IFNA1, IFNA2, CNTN2
13dexamethasone45 50 29 1112.9IFNA1, CXCL9, GDNF, CTLA4
14neopterin459.9CSF1, IFNA1, IFNA2, TNF
15ifn-alpha459.9CSF1, IFNA2, IFNA1, CXCL9
16thalidomide45 50 60 1112.9IFNA1, CTLA4, TNF, IFNA2
17ganglioside459.9CTLA4, MAG, CNTF, NGF, GDNF
1812-o-tetradecanoylphorbol 13-acetate459.9CSF1, NGF, CNTN2, IFNA2, CNTF
19cytarabine45 50 1111.8IFNA1, CSF1, IFNA2, NGF
20acetylcholine45 50 29 11 2413.8MAG, CTLA4, GDNF, NGF, CNTF
21prednisolone45 29 1111.8IFNA1, IFNA2, CSF1, TNF, NGF
22choline45 11 2411.8CNTF, CNTN2, NGF, GDNF
23con a459.7CD28, CTLA4, IFNA2
24ceramide459.7CNTN2, TNF, CD1D, NGF, CD28
25retinoid459.7CNTN2, CD1D, IFNA2, IFNA1, CSF1
26cyclic amp45 2410.6CNTF, MAG, CNTN2, GDNF, CD28
27tacrolimus45 50 1111.6GDNF, IFNA1, TNF, CD28, CTLA4
28ionomycin459.6TNF, CXCL9, CSF1, CD28, CNTN2, CTLA4
29actinomycin d459.6IFNA1, TNF, CNTF, NGF, CSF1, GDNF
30histamine45 29 2411.5IFNA2, TNF, NGF, CXCL9, FCGR2B, CNTF
31wortmannin459.5CNTF, GAS6, CD28, GDNF, NGF, CSF1
32pd 98,059459.5NGF, CNTF, TNF, CSF1, GDNF
33serine459.5TNF, GDNF, CSF1, MAG, CTLA4, FCGR2B
34genistein45 29 60 2 11 2414.5FCGR2B, CD28, GDNF, NGF, CNTF, CSF1
35cyclosporin a45 29 6011.4NGF, CTLA4, TNF, IFNA1, CD28, CNTN2
36phosphotyrosine459.4MAG, TUBB, CSF1, CD28, NGF, FYB
37h2o2459.4GDNF, CNTF, TNF, CSF1, CNTN2, TUBB
38rituximab45 50 1111.4CSF1, IFNA2, TNF, IFNA1, CTLA4, MAG
39tgf beta1459.4GDNF, CTLA4, CSF1, TNF
40ly294002459.3CSF1, TNF, CNTF, CTLA4, GAS6, NGF
41threonine459.3CD28, NGF, CNTN2, MAG, CNTF, CTLA4
42cysteine459.0CSF1, MAG, IFNA2, CD28, TUBB, GDNF
43retinoic acid45 249.9CNTF, AIF1, TNF, NGF, CD1D, GDNF
44phosphatidylinositol458.9CTLA4, GAS6, CSF1, CNTF, NGF, CD28
45vegf458.9NGF, IFNA2, CXCL9, GDNF, CNTF, CNTN2
46alanine458.9IFNA2, IFNA1, CSF1, CTLA4, MAG, NGF
47lipid458.8TNF, GDNF, FCGR2B, TUBB, CD28, CD1D
48thymidine45 249.7CTLA4, IFNA2, IFNA1, FCGR2B, NGF, CNTN2
49calcium45 50 11 2411.3CXCL9, FCGR2B, CLDN5, CD28, GDNF, AIF1
50tyrosine457.6NGF, AIRE, FCGR2B, FYB, CXCL9, GDNF

GO Terms for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.1AIF1, TNF
2paranode region of axonGO:03327010.0CLDN5, MAG
3Schmidt-Lanterman incisureGO:0432209.9MAG, CLDN5
4external side of plasma membraneGO:0098979.6TNF, CTLA4, CD28, CXCL9
5extracellular spaceGO:0056159.2CXCL9, NGF, CNTF, GAS6, TNF, CSF1
6plasma membraneGO:0058868.1TUBB, CSF1, TNF, CTLA4, AIRE, MAG

Biological processes related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.9GDNF, NGF, CNTF
2humoral immune responseGO:0069599.8TNF, AIRE, CD28
3positive regulation of T cell proliferationGO:0421029.7CD28, CD1D, AIF1
4immune responseGO:0069559.5CTLA4, AIRE, CXCL9, FYB, FCGR2B
5inflammatory responseGO:0069549.4CXCL9, NGF, AIF1, TNF, CSF1, IFNA2
6signal transductionGO:0071659.0GAS6, CNTF, GDNF, CXCL9, FYB, FCGR2B

Molecular functions related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.6GDNF, NGF, CNTF, CSF1
2identical protein bindingGO:0428029.4CLDN5, CD28, CNTN2, AIRE, TNF
3cytokine activityGO:0051259.4IFNA2, CSF1, TNF, CXCL9

Products for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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Sources for Chronic Inflammatory Demyelinating Polyneuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet