CIDP
MCID: CHR283
MIFTS: 52

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) malady

Rare diseases, Neuronal diseases categories
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Summaries for Chronic Inflammatory Demyelinating Polyneuropathy

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43NIH Rare Diseases, 44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. The disorder, which is sometimes called chronic relapsing polyneuropathy, is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves. Although it can occur at any age and in both genders, CIDP is more common in young adults, and in men more so than women. It often presents with symptoms that include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes (areflexia), fatigue, and abnormal sensations. CIDP is closely related to Guillain-Barre syndrome and it is considered the chronic counterpart of that acute disease.

MalaCards: Chronic Inflammatory Demyelinating Polyneuropathy, also known as chronic inflammatory demyelinating polyradiculoneuropathy, is related to polyneuropathy and hepatitis. An important gene associated with Chronic Inflammatory Demyelinating Polyneuropathy is AIF1 (allograft inflammatory factor 1), and among its related pathways are Tuberculosis and Jak-STAT signaling pathway. The drug immunoglobulins, intravenous and the compounds etanercept and rituximab have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and endothelial, and related mouse phenotypes are nervous system and behavior/neurological.

NIH Rare Diseases:43 Chronic inflammatory demyelinating polyneuropathy (cidp) is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. the disorder is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves. it often presents with symptoms that include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes, fatigue, and abnormal sensations. cidp is closely related to guillain-barre syndrome and it is considered the chronic counterpart of that acute disease. treatment may include corticosteroids, immunosuppressant drugs, plasma exchange, physiotherapy, and/or intravenous immunoglobulin (ivig) therapy. last updated: 8/1/2012

Wikipedia:65 Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory... more...

Aliases & Classifications for Chronic Inflammatory Demyelinating Polyneuropathy

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43NIH Rare Diseases, 49Orphanet, 44NINDS, 31LifeMap Discovery™, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
chronic inflammatory demyelinating polyneuropathy:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

chronic inflammatory demyelinating polyneuropathy 43 44 49 31
chronic inflammatory demyelinating polyradiculoneuropathy 43 49
cidp 43 49
polyradiculoneuropathy, chronic inflammatory demyelinating 62


External Ids:

ICD10 via Orphanet26 G61.8
UMLS via Orphanet63 C0393819
SNOMED-CT via Orphanet59 128209004

Related Diseases for Chronic Inflammatory Demyelinating Polyneuropathy

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17GeneCards, 18GeneDecks
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Diseases in the Chronic Inflammatory Demyelinating Polyneuropathy family:

Demyelinating Polyneuropathy Subacute Inflammatory Demyelinating Polyneuropathy

Diseases related to Chronic Inflammatory Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy32.4CNTF, IFNA2
2hepatitis30.9IFNA2, AIRE
3thrombocytopenia30.4IFNA2, FCGR2B
4type 1 diabetes mellitus30.4APOA4, AIRE
5demyelinating polyneuropathy11.6
6chronic inflammatory demyelinating polyradiculoneuropathy11.5
7polyradiculoneuropathy11.5
8neuropathy10.9
9diabetes mellitus10.6
10melanoma10.6
11myasthenia gravis10.6
12multiple sclerosis10.6
13blindness10.6
14poems syndrome10.5
15charcot-marie-tooth disease10.5
16respiratory failure10.5
17tooth disease10.5
18neuritis10.5
19autonomic dysfunction10.5
20hepatitis c10.4
21mononeuritis multiplex10.4
22neuronitis10.4
23hepatitis b10.4
24diabetic polyneuropathy10.4
25systemic lupus erythematosus10.4
26carpal tunnel syndrome10.4
27arthritis10.4
28glomerulonephritis10.4
29hypertension10.4
30intracranial hypertension10.4
31lupus erythematosus10.4
32mononeuritis10.4
33myopathy10.4
34tuberculosis10.4
35amyloid neuropathy10.4
36multifocal motor neuropathy10.4
37endotheliitis10.4
38graft versus host disease10.3
39crohn's disease10.3
40neurofibromatosis10.3
41evans' syndrome10.3
42cauda equina syndrome10.3
43radiculopathy10.3
44aseptic meningitis10.3
45arthropathy10.3
46inflammatory bowel disease10.3
47meningitis10.3
48optic neuritis10.3
49hereditary neuropathy with liability to pressure palsies10.3
50castleman's disease10.3

Graphical network of the top 20 diseases related to Chronic Inflammatory Demyelinating Polyneuropathy:



Diseases related to chronic inflammatory demyelinating polyneuropathy

Symptoms for Chronic Inflammatory Demyelinating Polyneuropathy

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Drugs & Therapeutics for Chronic Inflammatory Demyelinating Polyneuropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Chronic Inflammatory Demyelinating Polyneuropathy

Search NIH Clinical Center for Chronic Inflammatory Demyelinating Polyneuropathy

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Chronic Inflammatory Demyelinating Polyneuropathy:
Hematopoietic stem cells for treatment of chronic inflammatory demyelinating polyneuropathy
Embryonic/Adult Cultured Cells Related to Chronic Inflammatory Demyelinating Polyneuropathy:
Bone marrow-derived hematopoietic stem cells, PMID: 17277794

Genetic Tests for Chronic Inflammatory Demyelinating Polyneuropathy

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Anatomical Context for Chronic Inflammatory Demyelinating Polyneuropathy

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33MalaCards
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MalaCards organs/tissues related to Chronic Inflammatory Demyelinating Polyneuropathy:

33
T cells, Bone, Endothelial, Spinal cord, B cells, Skin, Thyroid, Liver, Brain, Dorsal root ganglion

Animal Models for Chronic Inflammatory Demyelinating Polyneuropathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Chronic Inflammatory Demyelinating Polyneuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1CNTF, FCGR2B, APOA4, AIRE
2MP:00053868.0AIRE, APOA4, FCGR2B, CNTF
3MP:00053847.8AIRE, APOA4, FCGR2B, CNTF
4MP:00053977.7CNTF, FCGR2B, APOA4, AIRE, AIF1
5MP:00053877.6AIF1, AIRE, APOA4, FCGR2B, CNTF

Publications for Chronic Inflammatory Demyelinating Polyneuropathy

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52PubMed
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Articles related to Chronic Inflammatory Demyelinating Polyneuropathy:

(show top 50)    (show all 421)
idTitleAuthorsYear
1
Distal acquired demyelinating symmetric polyneuropathy progressing to classic chronic inflammatory demyelinating polyneuropathy and response to fludarabine and cyclophosphamide. (23168526)
2013
2
Chronic inflammatory demyelinating polyneuropathy and metastatic melanoma. (23968958)
2013
3
Efficacy and safety of Privigen(Ar) in patients with chronic inflammatory demyelinating polyneuropathy: results of a prospective, single-arm, open-label Phase III study (the PRIMA study). (23781960)
2013
4
Brucellosis manifesting as chronic inflammatory demyelinating polyneuropathy. (22728867)
2012
5
Amyloid neuropathy mimicking chronic inflammatory demyelinating polyneuropathy. (22190302)
2012
6
Comment on acute-onset chronic inflammatory demyelinating polyneuropathy versus fluctuating Guillain-BarrAc syndrome. (21922476)
2011
7
Diagnostic and therapeutic challenges in chronic inflammatory demyelinating polyneuropathy and other immune-mediated neuropathies. (21157311)
2011
8
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. (19922956)
2010
9
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
10
Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. (20049473)
2010
11
Chronic inflammatory demyelinating polyneuropathy responsive to mycophenolate mofetil therapy. (20176598)
2010
12
The expression pattern of inflammatory mediators in cerebrospinal fluid differentiates Guillain-BarrAc syndrome from chronic inflammatory demyelinating polyneuropathy. (20538476)
2010
13
Chronic inflammatory demyelinating polyneuropathy disease activity status: recommendations for clinical research standards and use in clinical practice. (21199104)
2010
14
Coincident chronic inflammatory demyelinating polyneuropathy and focal segmental glomerulosclerosis: a common autoimmunity? (20049621)
2010
15
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
16
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (19915301)
2009
17
Fatigue in chronic inflammatory demyelinating polyneuropathy. (19347932)
2009
18
Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha. (19252365)
2009
19
Motor variant of chronic inflammatory demyelinating polyneuropathy in a child. (18486826)
2008
20
Post-influenza vaccine chronic inflammatory demyelinating polyneuropathy. (17993473)
2008
21
Neurophysiological evaluation of trigeminal and facial nerves in patients with chronic inflammatory demyelinating polyneuropathy. (18949780)
2008
22
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy. (17306302)
2007
23
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
24
Treatment-responsive pudendal dysfunction in chronic inflammatory demyelinating polyneuropathy. (17372137)
2007
25
High-dose cyclophosphamide results in long-term disease remission with restoration of a normal quality of life in patients with severe refractory chronic inflammatory demyelinating polyneuropathy. (15703014)
2005
26
Intractable chronic inflammatory demyelinating polyneuropathy treated successfully with ciclosporin. (16024890)
2005
27
Chronic inflammatory demyelinating polyneuropathy in patients with systemic lupus erythematosus: prognosis and outcome. (16325658)
2005
28
Chronic inflammatory demyelinating polyneuropathy after Campylobacter jejuni infection mimicking vasculitic mononeuritis multiplex in a diabetic. (15104697)
2004
29
Chronic Inflammatory Demyelinating Polyneuropathy. (12895398)
2003
30
Current concepts and controversy in chronic inflammatory demyelinating polyneuropathy. (12507413)
2003
31
Subarachnoid block for a patient with progressive chronic inflammatory demyelinating polyneuropathy. (11682419)
2001
32
Clinical and magnetic resonance imaging evidence of brain and spinal cord demyelination in a case of chronic inflammatory demyelinating polyneuropathy. (11437170)
2001
33
Treatment with interferon-alpha 2a in a patient with chronic inflammatory demyelinating polyneuropathy]. (10835937)
2000
34
Activity-dependent excitability changes in chronic inflammatory demyelinating polyneuropathy: A microneurographic study. (10398208)
1999
35
Advances in chronic inflammatory demyelinating polyneuropathy: disease variants and inflammatory response mediators and modifiers. (10555828)
1999
36
Chronic inflammatory demyelinating polyneuropathy (CIDP). (10689499)
1999
37
Clinicopathologic findings and prognosis of chronic inflammatory demyelinating polyneuropathy. (10025777)
1999
38
Focal lesions area feature of chronic inflammatory demyelinating polyneuropathy (CIDP). (9845290)
1998
39
Magnetic resonance imaging at the demyelinative foci in chronic inflammatory demyelinating polyneuropathy. (9109870)
1997
40
Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics. (8902721)
1996
41
Treatment of patients with chronic inflammatory demyelinating polyneuropathy. (8881435)
1996
42
Chronic inflammatory demyelinating polyneuropathy. (8907837)
1994
43
Magnetic resonance imaging of the cauda equina in chronic inflammatory demyelinating polyneuropathy. (8388677)
1993
44
Serum and CSF anti-GM1 antibodies in patients with Guillain-BarrAc syndrome and chronic inflammatory demyelinating polyneuropathy. (8433097)
1993
45
Chronic inflammatory demyelinating polyneuropathy in childhood: clinical and electrophysiological features. (1657385)
1991
46
CNS involvement in chronic inflammatory demyelinating polyneuropathy: an electrophysiological and MRI study. (1935761)
1991
47
Chronic inflammatory demyelinating polyneuropathy. Conduction failure before and during immunoglobulin or plasma therapy. (2597997)
1989
48
Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder. (3017185)
1986
49
Plasma exchange as sole treatment for chronic inflammatory demyelinating polyneuropathy. (3702800)
1986
50
Chronic inflammatory demyelinating polyneuropathy. (4086221)
1985

Variations for Chronic Inflammatory Demyelinating Polyneuropathy

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Expression for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

Search GEO for disease gene expression data for Chronic Inflammatory Demyelinating Polyneuropathy.

Pathways for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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50PathCards, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IFNA2, FCGR2B
2
Show member pathways
Type III interferon signaling38
9.1CNTF, IFNA2

Compounds for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1etanercept45 51 1111.7IFNA2, FCGR2B
2rituximab45 51 1111.5IFNA2, FCGR2B
3agarose459.4IFNA2, APOA4
4bromodeoxyuridine459.2AIF1, CNTF
5vitamin-e459.2CNTF, IFNA2
6histidine459.0CNTF, IFNA2, APOA4
7fatty acid458.9APOA4, IFNA2, CNTF
8histamine45 29 2410.9FCGR2B, IFNA2, CNTF
9superoxide45 249.8FCGR2B, IFNA2, CNTF
10thymidine45 249.8CNTF, IFNA2, FCGR2B
11glucose458.7CNTF, IFNA2, APOA4
12retinoic acid45 249.4CNTF, IFNA2, AIF1
13lipid458.4CNTF, IFNA2, FCGR2B, APOA4
14serine458.2AIRE, APOA4, FCGR2B, CNTF
15tyrosine458.1AIRE, FCGR2B, IFNA2, CNTF

GO Terms for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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16Gene Ontology
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Cellular components related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7CNTF, IFNA2, APOA4

Biological processes related to Chronic Inflammatory Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.1CNTF, IFNA2

Products for genes affiliated with Chronic Inflammatory Demyelinating Polyneuropathy

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Sources for Chronic Inflammatory Demyelinating Polyneuropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet