MCID: CHR067
MIFTS: 29

Chronic Intestinal Vascular Insufficiency

Categories: Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Chronic Intestinal Vascular Insufficiency

MalaCards integrated aliases for Chronic Intestinal Vascular Insufficiency:

Name: Chronic Intestinal Vascular Insufficiency 12 14
Chronic Mesenteric Ischemia 12 69
Cmi - Chronic Mesenteric Ischaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8633
ICD9CM 34 557.1
UMLS 69 C0311262

Summaries for Chronic Intestinal Vascular Insufficiency

MalaCards based summary : Chronic Intestinal Vascular Insufficiency, also known as chronic mesenteric ischemia, is related to fungal esophagitis and bladder calculus, and has symptoms including abdominal angina An important gene associated with Chronic Intestinal Vascular Insufficiency is NCR3 (Natural Cytotoxicity Triggering Receptor 3), and among its related pathways/superpathways are Ferroptosis and Fatty Acid Biosynthesis (WikiPathways).

Related Diseases for Chronic Intestinal Vascular Insufficiency

Diseases related to Chronic Intestinal Vascular Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 fungal esophagitis 10.4 ATP12A ATP4A
2 bladder calculus 10.4 ATP12A ATP4A
3 gastrointestinal neuroendocrine benign tumor 10.4 ATP12A ATP4A
4 gastric neuroendocrine neoplasm 10.4 ATP12A ATP4A
5 neonatal candidiasis 10.4 ATP12A ATP4A
6 photoallergic dermatitis 10.4 ATP12A ATP4A
7 squamous papillomatosis 10.4 ATP12A ATP4A
8 acute laryngitis 10.4 ATP12A ATP4A
9 gastroduodenal crohn's disease 10.4 ATP12A ATP4A
10 toxic megacolon 10.4 ATP12A ATP4A
11 aspiration pneumonitis 10.4 ATP12A ATP4A
12 gastric antral vascular ectasia 10.4 ATP12A ATP4A
13 esophageal candidiasis 10.4 ATP12A ATP4A
14 postsurgical hypothyroidism 10.4 ATP12A ATP4A
15 rumination disorder 10.4 ATP12A ATP4A
16 laryngeal disease 10.4 ATP12A ATP4A
17 duodenitis 10.4 ATP12A ATP4A
18 congenital disorder of deglycosylation 10.4 ATP12A ATP4A
19 bile reflux 10.4 ATP12A ATP4A
20 granulomatous gastritis 10.4 ATP12A ATP4A
21 active peptic ulcer disease 10.4 ATP12A ATP4A
22 dyskinesia of esophagus 10.4 ATP12A ATP4A
23 ischemic neuropathy 10.4 ATP12A ATP4A
24 anismus 10.3 ATP12A ATP4A
25 capillary disease 10.3 ATP12A ATP4A
26 peptic esophagitis 10.3 ATP12A ATP4A
27 duodenal disease 10.3 ATP12A ATP4A
28 hernia, hiatus 10.3 ATP12A ATP4A
29 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
30 laryngitis 10.3 ATP12A ATP4A
31 laryngeal tuberculosis 10.3 ATP12A ATP4A
32 lymphocytic colitis 10.3 ATP12A ATP4A
33 clostridium difficile colitis 10.3 ATP12A ATP4A
34 lower urinary tract calculus 10.3 ATP12A ATP4A
35 diarrhea 1, secretory chloride, congenital 10.3 ATP12A ATP4A
36 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 ATP12A ATP4A
37 aspiration pneumonia 10.3 ATP12A ATP4A
38 chronic laryngitis 10.3 ATP12A ATP4A
39 esophageal varix 10.3 ATP12A ATP4A
40 eosinophilic gastritis 10.3 ATP12A ATP4A
41 myopathy, x-linked, with excessive autophagy 10.3 ATP12A ATP4A
42 esophagus adenocarcinoma 10.3 ATP12A ATP4A
43 jejunoileitis 10.3 ATP12A ATP4A
44 pancreatic steatorrhea 10.2 ATP12A ATP4A
45 pneumatosis cystoides intestinalis 10.2 ATP12A ATP4A
46 superior mesenteric artery syndrome 10.2 ATP12A ATP4A
47 lateral medullary syndrome 10.2 ATP12A ATP4A
48 functional gastric disease 10.2 ATP12A ATP4A SPAG7
49 paine syndrome 10.2 ATP12A ATP4A
50 ischemia 10.2

Comorbidity relations with Chronic Intestinal Vascular Insufficiency via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Aortic Valve Disease 1 Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Intestinal Obstruction Iron Deficiency Anemia
Ischemic Heart Disease Mitral Valve Disease
Paralytic Ileus Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Chronic Intestinal Vascular Insufficiency:



Diseases related to Chronic Intestinal Vascular Insufficiency

Symptoms & Phenotypes for Chronic Intestinal Vascular Insufficiency

UMLS symptoms related to Chronic Intestinal Vascular Insufficiency:


abdominal angina

Drugs & Therapeutics for Chronic Intestinal Vascular Insufficiency

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of Chronic Intestinal Ischemia Recruiting NCT02914912 Phase 1, Phase 2

Search NIH Clinical Center for Chronic Intestinal Vascular Insufficiency

Genetic Tests for Chronic Intestinal Vascular Insufficiency

Anatomical Context for Chronic Intestinal Vascular Insufficiency

Publications for Chronic Intestinal Vascular Insufficiency

Articles related to Chronic Intestinal Vascular Insufficiency:

# Title Authors Year
1
Ascending Aorta to Hepatic and Mesenteric Artery Bypassing, in Patients with Chronic Mesenteric Ischemia and Extensive Aortic Disease-A Case Report and Review of the Literature. ( 27908818 )
2016
2
Acute acalculous cholecystitis as a rare manifestation of chronic mesenteric ischemia. A case report. ( 27394394 )
2016
3
Prolonged idiopathic gastric dilatation following revascularization for chronic mesenteric ischemia. ( 24975870 )
2014
4
Median arcuate ligament syndrome: Use of fractional flow reserve in documentation of chronic mesenteric ischemia. ( 24939929 )
2014
5
Ileocolic to right iliac arterial transposition for the treatment of chronic mesenteric ischemia. ( 24436624 )
2013
6
A rare cause of chronic mesenteric ischemia from fibromuscular dysplasia: a case report. ( 21092091 )
2010
7
Three cases of chronic mesenteric ischemia presenting as abdominal pain and Helicobacter pylori-negative gastric ulcer. ( 15628740 )
2004

Variations for Chronic Intestinal Vascular Insufficiency

Expression for Chronic Intestinal Vascular Insufficiency

Search GEO for disease gene expression data for Chronic Intestinal Vascular Insufficiency.

Pathways for Chronic Intestinal Vascular Insufficiency

Pathways related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.76 ACSL5 ACSL6
2 10.3 ACSL5 ACSL6
3 9.74 ACSL5 ACSL6

GO Terms for Chronic Intestinal Vascular Insufficiency

Biological processes related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mesoderm formation GO:0001707 9.26 GPI WLS
2 long-chain fatty acid metabolic process GO:0001676 9.16 ACSL5 ACSL6
3 long-chain fatty-acyl-CoA biosynthetic process GO:0035338 8.96 ACSL5 ACSL6
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-chain fatty acid-CoA ligase activity GO:0004467 9.26 ACSL5 ACSL6
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 decanoate--CoA ligase activity GO:0102391 8.96 ACSL5 ACSL6
4 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Chronic Intestinal Vascular Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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