CRF
MCID: CHR089
MIFTS: 65

Chronic Kidney Failure (CRF) malady

Genetic diseases, Nephrological diseases, Rare diseases, Fetal diseases categories
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Summaries for Chronic Kidney Failure

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 You have two kidneys, each about the size of your fist. their main job is to filter wastes and excess water out of your blood to make urine. they also keep the body's chemical balance, help control blood pressure, and make hormones. chronic kidney disease (ckd) means that your kidneys are damaged and can't filter blood as they should. this damage can cause wastes to build up in your body. it can also cause other problems that can harm your health. diabetes and high blood pressure are the most common causes of ckd. treatment may include medicines to lower blood pressure, control blood glucose, and lower blood cholesterol. ckd can get worse over time. ckd may lead to kidney failure. the only treatment options for kidney failure are dialysis or a kidney transplantation. you can take steps to keep your kidneys healthier longer: choose foods with less salt (sodium) keep your blood pressure below 130/80 keep your blood glucose in the target range, if you have diabetes nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Chronic Kidney Failure, also known as chronic renal failure syndrome, is related to coronary artery disease and myocardial infarction. An important gene associated with Chronic Kidney Failure is FAN1 (FANCD2/FANCI-associated nuclease 1), and among its related pathways are Diseases associated with visual transduction and Lipoprotein metabolism. The drugs cholecalciferol and calcium carbonate and the compounds gemfibrozil and triacylglycerol have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow.

Wikipedia:65 Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

Aliases & Classifications for Chronic Kidney Failure

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Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 27ICD9CM, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

chronic kidney failure 8 31
chronic renal failure syndrome 8
chronic kidney insufficiency 62
renal failure - chronic 8
kidney failure, chronic 62
chronic kidney disease 34
renal failure chronic 45
chronic renal disease 8
crf 8


External Ids:

Disease Ontology8 DOID:784
ICD9CM27 585.6
MeSH35 D007676
ICD1025 N18

Related Diseases for Chronic Kidney Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Chronic Kidney Failure family:

Acute Kidney Failure Kidney Disease
Renal Infectious Disease Ren-Related Kidney Disease
Renal Dysplasia

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease30.5APOC3, APOC2
2myocardial infarction30.4REN, APOC3
3hypertriglyceridemia30.2APOC2, APOC3
4type 2 diabetes mellitus30.1APOC3, APOC2
5diabetes mellitus29.9APOC3, REN, APOC2, CYP27B1
6proteinuria29.8APOC3, APOC2, REN
7metabolic acidosis10.5
8neuronitis10.5
9vascular disease10.5
10systolic heart failure10.4
11gout10.4
12deficiency anemia10.3
13iron deficiency anemia10.3
14calciphylaxis10.3
15artery disease10.3
16alzheimer's disease10.3
17polycystic kidney disease10.3
18diastolic heart failure10.3
19sagliker syndrome10.3
20fatty liver disease10.3
21liver disease10.3
22uremia10.3
23short stature10.3
24hepatitis c10.2
25hepatitis10.2
26hypertension10.2
27peritonitis10.2
28peripheral vascular disease10.2
29focal segmental glomerulosclerosis10.2
30nephrolithiasis10.2
31cerebritis10.2
32restless legs syndrome10.2
33arteriosclerosis10.2
34essential hypertension10.2
35glomerulosclerosis10.2
36hypothyroidism10.2
37neuropathy10.2
38renal cell carcinoma10.2
39nephrogenic systemic fibrosis10.2
40blindness10.2
41hyperphosphatemia10.2
42amenorrhea10.1
43anxiety disorder10.1
44bardet-biedl syndrome10.1
45familial juvenile hyperuricemic nephropathy10.1
46arteriolosclerosis10.1
47obstructive sleep apnea10.1
48fanconi syndrome10.1
49hyperhomocysteinemia10.1
50hypokalemia10.1

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to chronic kidney failure

Symptoms for Chronic Kidney Failure

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Drugs & Therapeutics for Chronic Kidney Failure

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Chronic Kidney Failure

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Kidney Failure

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Anatomical Context for Chronic Kidney Failure

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Chronic Kidney Failure:

33
Kidney, Bone, Bone marrow, Heart, Liver, Lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 KidneyProximal TubuleProximal Tubule Cells Potential therapeutic candidate, affected by disease
4 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Chronic Kidney Failure or affiliated genes

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Publications for Chronic Kidney Failure

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52PubMed
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Articles related to Chronic Kidney Failure:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Convective therapies versus low-flux hemodialysis for chronic kidney failure: a meta-analysis of randomized controlled trials. (24081858)
2013
2
Effectiveness of a nurse-led intensive educational programme on chronic kidney failure patients with hyperphosphataemia: randomised controlled trial. (23480506)
2013
3
Comment on the question 'Are the aims of the K/DOQI guidelines for mineral metabolism disorders in predialysis chronic kidney failure unachievable or inadequate?'. (23712231)
2013
4
Activities of lipogenic enzymes in subcutaneous adipose tissue are not increased in patients with chronic kidney failure. (23160012)
2013
5
Changes in bone matrix mineralization after growth hormone treatment in children and adolescents with chronic kidney failure treated by dialysis: a paired biopsy study. (23465957)
2013
6
Micromolecular multiple myeloma with chronic kidney failure in a young female patient on continuous hemodialysis. (23529328)
2013
7
Paraoxonase 1 in chronic kidney failure. (22523692)
2012
8
ECG of the month. Electrocardiogram in a man with chronic kidney failure. ECG is abnormal and indicative of heart disease. (23362595)
2012
9
Ask the doctors. I am 71 years old, have chronic kidney failure, and am on dialysis. I know my overall outlook is not good, and I wonder whether it is worth it to take a statin to control my cholesterol. (23476941)
2012
10
Peginesatide (Omontys) for anemia in chronic kidney failure. (22683926)
2012
11
High-flux and low-flux dialysis membranes and levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in children with chronic kidney failure. (22976263)
2012
12
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. (22772369)
2012
13
Pathology in practice. Chronic kidney failure. (21401426)
2011
14
Etanercept treatment in rheumatoid arthritis patients with chronic kidney failure on predialysis. (19705121)
2010
15
Hemolysis in a patient with alkaptonuria and chronic kidney failure. (20207456)
2010
16
Malnutrition in chronic kidney failure: what is the best diagnostic method to assess?]. (21448521)
2010
17
Induction of chronic kidney failure in a long-term peritoneal exposure model in the rat: effects on functional and structural peritoneal alterations. (20421431)
2010
18
71-year-old man with chronic kidney failure and sudden change of mental status. (19880683)
2009
19
Causes and prevention of protein-energy wasting in chronic kidney failure. (19121473)
2009
20
Genotype 1 hepatitis C virus infection predominates among patients with chronic kidney failure and renal allograft recipients in India. (19937412)
2009
21
Leptin and lipid metabolism in chronic kidney failure. (19148833)
2009
22
How do families adjust to having a child with chronic kidney failure? A systematic review. (18472684)
2008
23
Metabolic disorders in patients with chronic kidney failure. (17298212)
2007
24
Phenylalanine and tyrosine metabolism in chronic kidney failure. (17513431)
2007
25
Vascular calcification in chronic kidney failure: role of vitamin D receptor. (17408120)
2007
26
Combined therapy with L-carnitine and erythropoietin of anemia in chronic kidney failure patients undergoing hemodialysis]. (17642201)
2007
27
Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure. (16871242)
2006
28
Cardiovascular disease in chronic kidney failure: the role of VDR activators. (16555680)
2006
29
Fluvastatin in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation. (15957541)
2005
30
The effects of serum calcium and parathyroid hormone and the interaction between them on blood pressure in normal subjects and in patients with chronic kidney failure. (15648029)
2005
31
Replicative senescence in patients with chronic kidney failure. (16336562)
2005
32
Cardiovascular disease in chronic kidney failure: is there a role for vitamin D analogs? (15816500)
2005
33
State-specific trends in chronic kidney failure--United States, 1990-2001. (15470324)
2004
34
Medical nutrition therapy in chronic kidney failure: integrating clinical practice guidelines. (14993863)
2004
35
A comparison of clinically useful phosphorus binders for patients with chronic kidney failure. (15296504)
2004
36
Relationships of race and ethnicity to progression of kidney dysfunction and clinical outcomes in patients with chronic kidney failure. (14730535)
2004
37
Lipoprotein disorders in chronic kidney failure, nephrotic syndrome and dialysis]. (12679979)
2002
38
Modes of intensive therapy for arterial hypertension in children with terminal chronic kidney failure]. (12180062)
2002
39
Extraskeletal calcification in patients with chronic kidney failure. (11068650)
2000
40
Relation between parathormone and 1,25-dihydroxyvitamin D3 in chronic kidney failure]. (9750473)
1997
41
Severity of acquired cystic kidney disease determines improvement in chronic kidney failure anemia]. (9224984)
1997
42
The characteristics of disorders in carbohydrate metabolism and insulin and C-peptide secretion in patients with chronic glomerulonephritis in developing chronic kidney failure]. (8771677)
1996
43
The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. (7532880)
1994
44
Iron stores in patients with chronic kidney failure treated with recombinant human erythropoietin]. (8184571)
1994
45
Gastric intramucosal acidosis in patients with chronic kidney failure. (8488469)
1993
46
Effect of hemodialysis on levels of parathormone in blood of patients with chronic kidney failure]. (8249416)
1993
47
Determination of lactoferrin in the diagnosis of pancreatopathy in patients with chronic kidney failure]. (1561772)
1992
48
The treatment of severe arterial hypertension in patients with chronic kidney failure with captopril and beta-adrenoblockaders]. (1871923)
1991
49
Metabolic consequences of feeding a high-carbohydrate, high-fiber diet to diabetic patients with chronic kidney failure. (2841839)
1988
50
Does chronic kidney failure lead to mental failure? A neuropsychologic survey of self-sufficient outpatients. (6797387)
1981

Variations for Chronic Kidney Failure

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Expression for genes affiliated with Chronic Kidney Failure

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Kidney Failure

Search GEO for disease gene expression data for Chronic Kidney Failure.

Pathways for genes affiliated with Chronic Kidney Failure

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB
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Compounds for genes affiliated with Chronic Kidney Failure

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Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB, 51PharmGKB
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Compounds related to Chronic Kidney Failure according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1gemfibrozil29 45 1111.7APOC2, APOC3
2triacylglycerol459.7APOC2, APOC3
3homocysteine45 2410.6APOC2, APOC3
4methionine459.4APOC2, APOC3
5polyacrylamide459.3APOC3, APOC2
6nacl459.2APOC2, REN
7calcitriol45 61 24 1112.1REN, CYP27B1
8vitamin a45 24 1111.1APOC2, APOC3, CYP27B1
9chloramphenicol45 3 51 1112.0APOC3, CYP27B1
10retinoic acid45 2410.0APOC2, APOC3, CYP27B1
11creatinine458.8APOC3, APOC2, REN
12lipid458.8APOC2, APOC3, CYP27B1
13steroid458.7CYP27B1, APOC3, REN
14cholesterol45 29 24 1111.3REN, APOC2, APOC3, CYP27B1
15glucose458.3CYP27B1, APOC3, APOC2, REN

GO Terms for genes affiliated with Chronic Kidney Failure

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16Gene Ontology
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Cellular components related to Chronic Kidney Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:0343639.6APOC3, APOC2
2spherical high-density lipoprotein particleGO:0343669.5APOC3, APOC2
3chylomicronGO:0426279.5APOC3, APOC2
4very-low-density lipoprotein particleGO:0343619.4APOC3, APOC2
5early endosomeGO:0057699.3APOC3, APOC2
6extracellular regionGO:0055768.6APOC3, APOC2, REN
7extracellular spaceGO:0056158.3APOC3, APOC2, REN

Biological processes related to Chronic Kidney Failure according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of very-low-density lipoprotein particle clearanceGO:0109169.7APOC3, APOC2
2negative regulation of lipid metabolic processGO:0458339.7APOC3, APOC2
3chylomicron remnant clearanceGO:0343829.7APOC2, APOC3
4negative regulation of receptor-mediated endocytosisGO:0482619.7APOC3, APOC2
5phospholipid effluxGO:0337009.7APOC2, APOC3
6lipoprotein transportGO:0429539.7APOC3, APOC2
7reverse cholesterol transportGO:0436919.7APOC3, APOC2
8triglyceride homeostasisGO:0703289.6APOC2, APOC3
9cholesterol effluxGO:0333449.6APOC3, APOC2
10lipoprotein metabolic processGO:0421579.6APOC2, APOC3
11retinoid metabolic processGO:0015239.5APOC3, APOC2
12cholesterol homeostasisGO:0426329.5APOC3, APOC2
13phototransduction, visible lightGO:0076039.4APOC2, APOC3
14response to drugGO:0424939.4APOC3, APOC2
15response to lipopolysaccharideGO:0324968.9REN, CYP27B1
16small molecule metabolic processGO:0442818.5CYP27B1, APOC3, APOC2

Molecular functions related to Chronic Kidney Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipase inhibitor activityGO:0551029.4APOC2, APOC3

Products for genes affiliated with Chronic Kidney Failure

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Kidney Failure

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet