MCID: CHR089
MIFTS: 65

Chronic Kidney Failure

Categories: Nephrological diseases, Genetic diseases

Aliases & Classifications for Chronic Kidney Failure

MalaCards integrated aliases for Chronic Kidney Failure:

Name: Chronic Kidney Failure 38 12
Chronic Kidney Disease 12 29 41 3 14
Kidney Failure, Chronic 42 69
Ckd 12 3
Chronic Renal Failure Syndrome 12
Renal Failure - Chronic 12
Chronic Kidney Diseases 69
Chronic Renal Disease 12
Renal Failure Chronic 52
Crf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:784
ICD10 33 N18.9 N18
ICD9CM 35 585.6
MeSH 42 D007676
NCIt 47 C9438
UMLS 69 C0022661

Summaries for Chronic Kidney Failure

MedlinePlus : 41 you have two kidneys, each about the size of your fist. their main job is to filter wastes and excess water out of your blood to make urine. they also keep the body's chemical balance, help control blood pressure, and make hormones. chronic kidney disease (ckd) means that your kidneys are damaged and can't filter blood as they should. this damage can cause wastes to build up in your body. it can also cause other problems that can harm your health. diabetes and high blood pressure are the most common causes of ckd. the kidney damage occurs slowly over many years. many people don't have any symptoms until their kidney disease is very advanced. blood and urine tests are the only way to know if you have kidney disease. treatment may include medicines to lower blood pressure, control blood glucose, and lower blood cholesterol. ckd can get worse over time. ckd may lead to kidney failure. the only treatment options for kidney failure are dialysis or a kidney transplantation. you can take steps to keep your kidneys healthier longer: choose foods with less salt (sodium) keep your blood pressure below 130/80 keep your blood glucose in the target range, if you have diabetes nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Chronic Kidney Failure, also known as chronic kidney disease, is related to pyelonephritis and cystinosis, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Failure is PKD2 (Polycystin 2, Transient Receptor Potential Cation Channel), and among its related pathways/superpathways are HIF-1 signaling pathway and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Heparin and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Chronic kidney disease (CKD) is progressive loss in kidney function over a period of months or years.... more...

Related Diseases for Chronic Kidney Failure

Diseases in the Kidney Disease family:

Acute Kidney Failure Chronic Kidney Failure
Renal Infectious Disease Ren-Related Kidney Disease

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
id Related Disease Score Top Affiliating Genes
1 pyelonephritis 30.5 ACE CRP REN
2 cystinosis 30.2 ACE AGT ALB CRP REN
3 midface dysplasia 11.1 ALB TTR
4 male genital organ stricture 11.1 ALB TF TTR
5 female infertility of uterine origin 11.1 ALB TF TTR
6 cerebral sarcoidosis 11.1 ALB EPO TF
7 bacteriuria 11.1 B2M TF TTR
8 cataract 11.1 ALB INS TTR
9 hypothyroidism due to iodide transport defect 11.1 ACE REN
10 tinf2-related dyskeratosis congenita 11.0 INS TF VDR
11 early-onset severe reducing body myopathy, x-linked 11.0 ALB TTR
12 macular dystrophy, patterned, 1 11.0 B2M TF TTR
13 conjunctival vascular disease 11.0 ALB EPO INS
14 nephrocalcinosis 11.0
15 hemopericardium 11.0 ALB INS TTR
16 clitoris cancer 11.0 ACE EPO REN
17 sleep disorder 11.0 ALB TF TTR
18 wernicke-korsakoff syndrome 11.0 ALB REN
19 chronic fungal otitis externa 11.0 CRP INS
20 histiocytoid hemangioma 11.0 ALB FGF23 VDR
21 poems syndrome 11.0 CRP EPO TF
22 cataract 25 11.0 ALB B2M
23 chronic inflammatory demyelinating polyradiculoneuropathy 11.0 ALB B2M REN
24 speech and communication disorders 11.0 ALB CRP TTR
25 milker's nodule 11.0 ALB CRP TTR
26 primary hyperoxaluria 11.0 ACE REN
27 breast mucoepidermoid carcinoma 11.0 B2M EPO PTH
28 paranasal sinus sarcoma 11.0 ALB REN TTR
29 glycogen storage disease viii 11.0 B2M CRP REN
30 eustachian tube disease 11.0 B2M CRP REN
31 amyloidosis nodular localized cutaneous 11.0 B2M CRP TTR
32 pelizaeus-merzbacher-like disease 11.0 ACE AGT
33 bladder sarcoma 11.0 ALB LEP TF TTR
34 plummer's disease 11.0 ALB B2M CRP
35 fissured tongue 10.9 ALB EPO INS
36 spastic monoplegia 10.9 ALB NPHS2 TF
37 non-congenital cyst of kidney 10.9 ACE ALB B2M REN
38 osteochondrodysplasia 10.9 HMGCR PTH VDR
39 broad ligament malignant neoplasm 10.9 ACE ALB EPO REN
40 chylocele of tunica vaginalis 10.9 ACE AGT REN
41 cataract, autosomal dominant congenital 4 10.9 ACE AGT INS
42 fibular aplasia ectrodactyly 10.9 ACE AGT REN
43 blind hypotensive eye 10.9 CRP EPO TF
44 iga glomerulonephritis 10.9 ALB REN
45 chondroma 10.9 CRP INS LEP
46 cascade stomach 10.9 ACE AGT REN
47 spastic entropion 10.9 ALB CRP TF TTR
48 renal tubular dysgenesis 10.9 ACE AGT REN
49 pyogenic arthritis, pyoderma gangrenosum and acne 10.9 ACE EPO REN TTR
50 ischemic heart disease 10.9 ACE ALB CRP

Comorbidity relations with Chronic Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 114)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Alcoholic Liver Cirrhosis
Amyloidosis Aplastic Anemia
Bacteremia Benign Essential Hypertension
Benign Hypertensive Renal Disease Benign Renovascular Hypertension
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Myocardial Ischemia
Chronic Rapidly Progressive Glomerulonephritis Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Disseminated Intravascular Coagulation Duodenitis
Encephalopathy Esophageal Candidiasis
Esophageal Disease Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Goodpasture Syndrome
Gout Heart Conduction Disease
Heart Disease Hemolytic-Uremic Syndrome
Hepatic Encephalopathy Hepatorenal Syndrome
Hydronephrosis Hyperparathyroidism
Hypertension, Essential Hypertensive Encephalopathy

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to Chronic Kidney Failure

Symptoms & Phenotypes for Chronic Kidney Failure

UMLS symptoms related to Chronic Kidney Failure:


cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to Chronic Kidney Failure:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.39 ACE AGT B2M CRP CST3 EPO
2 homeostasis/metabolism MP:0005376 10.38 TTR VDR ACE AGT ALB B2M
3 growth/size/body region MP:0005378 10.3 ACE AGT B2M FGF23 HMGCR INS
4 endocrine/exocrine gland MP:0005379 10.22 ALB B2M FGF23 INS LEP MKS1
5 hematopoietic system MP:0005397 10.21 ACE B2M EPO FGF23 INS LEP
6 mortality/aging MP:0010768 10.19 MKS1 NPHS2 PKD2 PTH REN TF
7 immune system MP:0005387 10.18 EPO FGF23 INS LEP MKS1 PKD2
8 digestive/alimentary MP:0005381 10.1 MKS1 PKD2 VDR ALB B2M FGF23
9 liver/biliary system MP:0005370 10.02 ACE AGT ALB B2M EPO HMGCR
10 muscle MP:0005369 9.76 AGT ALB CST3 EPO INS LEP
11 renal/urinary system MP:0005367 9.73 ACE AGT ALB FGF23 INS LEP
12 reproductive system MP:0005389 9.36 AGT B2M CST3 FGF23 INS LEP

Drugs & Therapeutics for Chronic Kidney Failure

Drugs for Chronic Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 846)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
2
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
3
Ezetimibe Approved Phase 4 163222-33-1 150311
4
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
5
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
6
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
7
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 104987-11-3 445643 439492
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-78-2 2244
9
Digoxin Approved Phase 4 20830-75-5 30322 2724385
10
Colchicine Approved Phase 4,Phase 2 64-86-8 6167 2833
11
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
12
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 54-31-9 3440
13
Mycophenolic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 24280-93-1 446541
14
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 128794-94-5 5281078
15
Nifedipine Approved Phase 4,Phase 2,Phase 1 21829-25-4 4485
16
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 75847-73-3 5362032 40466924
17
Ramipril Approved Phase 4,Phase 3,Phase 2 87333-19-5 5362129
18
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
19
Fosinopril Approved Phase 4,Phase 3 98048-97-6 55891
20
Enalaprilat Approved Phase 4,Phase 3,Phase 1,Phase 2 76420-72-9 6917719
21
Losartan Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 114798-26-4 3961
22
Spironolactone Approved Phase 4,Phase 3,Phase 2,Phase 1 1952-01-7, 52-01-7 5833
23
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
24
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 1 58-93-5 3639
25
Candesartan Approved Phase 4,Phase 3 139481-59-7 2541
26
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
27
Bisoprolol Approved Phase 4 66722-44-9 2405
28
Eplerenone Approved Phase 4,Phase 3,Phase 2,Phase 1 107724-20-9 150310 443872
29
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
30
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
31
Ribavirin Approved Phase 4,Phase 3,Phase 1,Phase 2 36791-04-5 37542
32
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
33
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 174722-31-7 10201696
34
Ticlopidine Approved Phase 4,Phase 3,Phase 1 55142-85-3 5472
35
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2 58-61-7 60961
36
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
37
Icodextrin Approved, Investigational Phase 4,Phase 3,Phase 2 337376-15-5
38
Capsaicin Approved Phase 4 404-86-4 1548943
39
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
40
Sevelamer Approved Phase 4,Phase 3,Phase 2,Phase 1 52757-95-6, 152751-57-0 3085017
41
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
42
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
43
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
44
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
45
Basiliximab Approved, Investigational Phase 4,Phase 2,Phase 3 152923-56-3, 179045-86-4
46
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2 216503-57-0
47
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
48
Daclizumab Approved, Investigational Phase 4,Phase 3 152923-56-3
49
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
50
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603

Interventional clinical trials:

(show top 50) (show all 2856)

id Name Status NCT ID Phase Drugs
1 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
2 Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
3 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
4 Effect of Sodium Rinsing Fluid on Blood Pressure and Interdialytic Weight Change in Hemodialysis Patients Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
5 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
6 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
7 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
8 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
9 Aspirin in the Prevention of Cardiovascular Events in Hemodialysis Patients Unknown status NCT01198379 Phase 4 aspirin;Placebo
10 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
11 Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
12 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
13 Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
14 Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
15 Body Composition Monitor in Hemodialysis Patients Unknown status NCT01103167 Phase 4
16 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
17 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4 Oxycodone
18 Cardiovascular Protective Effect of Spironolactone in Hemodialysis Unknown status NCT00277693 Phase 4 Spironolactone (drug)
19 Hypervolemia in ESRD Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
20 More Frequent Dialysis (>3 Treatments Per Week) Unknown status NCT00575497 Phase 4
21 Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Unknown status NCT00807144 Phase 4 Tacrolimus (Kidney transplant maintenance immunosuppression);Kidney transplant maintenance immunosuppression
22 Open-label, Randomized Trial to Determine the Effect of Icodextrin Versus Dextrose (Dianeal 2.5%) in HOMA IR Unknown status NCT01093547 Phase 4
23 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4 N-acetylcysteine
24 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
25 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
26 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
27 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
28 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
29 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
30 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
31 The Effect of Uric Acid Lowering in Type 1 Diabetes Unknown status NCT02344602 Phase 4 Febuxostat
32 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
33 Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function Unknown status NCT01977430 Phase 4 Hydrochlorothiazide and furosemide
34 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
35 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
36 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
37 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
38 Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
39 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
40 Intravenous Iron in Patients With Anemia of Chronic Kidney Disease Unknown status NCT00204256 Phase 4 Iron sucrose
41 Value Antiproteinuric Effects From Vitamin D Derivatives in Patient With Chronic Kidney Illness and the Lack of Vitamin D Unknown status NCT01442272 Phase 4 Hidroferol®;Paricalcitol: Zemplar®;Habitual medication
42 Mineralocorticoid Receptor Antagonist and Kidney Allograft Histology Unknown status NCT01510795 Phase 4 spironolactone
43 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
44 Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease Unknown status NCT00235287 Phase 4 Candesartan and enalapril;candesartan and enalapril;candesartan and enalapril;candesartan and enalapril
45 Effects of Spironolactone in Dialysis Unknown status NCT01128101 Phase 4 Spironolactone
46 Effect of 3g Versus 2 g MMF in Combination With Tacrolimus on Progression of Renal Allograft Interstitial Fibrosis Unknown status NCT01860183 Phase 4 Mycophenolate mofetil
47 Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction Unknown status NCT01580046 Phase 4 iodixanol;iopromide
48 The Prevention of Contrast Induced Nephropathy by Sarpogrelate in Patients With Chronic Kidney Disease Unknown status NCT01165567 Phase 4 sarpogrelate
49 Hemocontrol's Effectiveness on the Reduction of Cardiovascular Long-term EventS Unknown status NCT01515878 Phase 4
50 Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease Unknown status NCT02299310 Phase 4 Valsartan;Perindopril

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: kidney failure, chronic

Genetic Tests for Chronic Kidney Failure

Genetic tests related to Chronic Kidney Failure:

id Genetic test Affiliating Genes
1 Chronic Kidney Disease 29

Anatomical Context for Chronic Kidney Failure

MalaCards organs/tissues related to Chronic Kidney Failure:

39
Kidney, Heart, Bone, Endothelial, Testes, Liver, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Potential therapeutic candidate, affected by disease
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Chronic Kidney Failure

Articles related to Chronic Kidney Failure:

(show top 50) (show all 112)
id Title Authors Year
1
Effects of Intradialytic Neuromuscular Electrical Stimulation on Strength and Muscle Architecture in Patients With Chronic Kidney Failure: Randomized Clinical Trial. ( 28621488 )
2017
2
Polyomavirus BK and JC in individuals with chronic kidney failure, kidney transplantation, and healthy controls. ( 28189092 )
2017
3
Osthole protects against inflammation in a rat model of chronic kidney failure via suppression of nuclear factor-I_B, transforming growth factor-I^1 and activation of phosphoinositide 3-kinase/protein kinase B/nuclear factor (erythroid-derived 2)-like 2 signaling. ( 28765904 )
2017
4
Mechanism Underlying Linezolid-induced Thrombocytopenia in a Chronic Kidney Failure Mouse Model. ( 28405130 )
2017
5
Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia. ( 28042744 )
2017
6
Impact of Gate 99mTc DTPA GFR, Serum Creatinine and Urea in Diagnosis of Patients with Chronic Kidney Failure. ( 28883673 )
2017
7
Checkpoint inhibitors in chronic kidney failure and an organ transplant recipient. ( 27614165 )
2016
8
Brown tumour in phalanx of the ring finger due to chronic kidney failure. A case report. ( 27894859 )
2016
9
NEW INSIGHTS INTO THE EFFECTS OF CHRONIC KIDNEY FAILURE AND DIALYSATE EXPOSURE ON THE PERITONEUM. ( 27147290 )
2016
10
Indication for Dialysis Initiation and Mortality in Patients With Chronic Kidney Failure: A Retrospective Cohort Study. ( 27637132 )
2016
11
Reappraisal in two European cohorts ofA theA prognostic power of left ventricular massA indexA in chronic kidney failure. ( 28010886 )
2016
12
Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load. ( 26769003 )
2016
13
Assessment of erythropoietin for treatment of anemia in chronic kidney failure- ESRD patients. ( 27470337 )
2016
14
Latinos With Chronic Kidney Failure Treated by Dialysis: Understanding Their Palliative Care Perspectives. ( 26612276 )
2016
15
Lymphangiogenesis and Lymphatic Absorption Are Related and Increased in Chronic Kidney Failure, Independent of Exposure to Dialysis Solutions. ( 26714383 )
2015
16
Sudden Visual Deterioration as the First Symptom of Chronic Kidney Failure. ( 26955339 )
2015
17
Grover's disease in chronic kidney failure. ( 26299177 )
2015
18
Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure. ( 26221597 )
2015
19
Does the Stage of Chronic Kidney Failure Influence the Outcome in Cardiac Surgery? ( 26768636 )
2015
20
Enhanced Psychosocial Support for Caregiver Burden forA Patients With Chronic Kidney Failure Choosing NotA toA BeA Treated by Dialysis or Transplantation: A Pilot Randomized Controlled Trial. ( 26549852 )
2015
21
Icariin protects rats against 5/6 nephrectomy-induced chronic kidney failure by increasing the number of renal stem cells. ( 26490949 )
2015
22
Neutrophil gelatinase-associated lipocalin as early predictor of acute kidney injury after cardiac surgery in adults with chronic kidney failure. ( 25595830 )
2015
23
Association of dialysis adequacy with nutritional and inflammatory status in patients with chronic kidney failure. ( 26586053 )
2015
24
Peritoneal dialysis in China: meeting the challenge of chronic kidney failure. ( 25446022 )
2015
25
Reduced Cardiovascular Reserve in Chronic Kidney Failure: AA Matched Cohort Study. ( 25900597 )
2015
26
Familial mixed nephrocalcinosis as a cause of chronic kidney failure: two case reports. ( 25346103 )
2014
27
Association of PTH and carotid thickness in patients with chronic kidney failure and secondary hyperparathyroidism. ( 25317613 )
2014
28
Understanding by Older Patients of Dialysis and Conservative Management for Chronic Kidney Failure. ( 25304984 )
2014
29
Effect of hemodiafiltration or hemofiltration compared with hemodialysis on mortality and cardiovascular disease in chronic kidney failure: a systematic review and meta-analysis of randomized trials. ( 24685515 )
2014
30
Convective Versus Diffusive Dialysis Therapies for Chronic Kidney Failure: An Updated Systematic Review of Randomized Controlled Trials. ( 24434188 )
2014
31
Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. ( 24856028 )
2014
32
Patient engagement and patient-centred care in the management of advanced chronic kidney disease and chronic kidney failure. ( 25780613 )
2014
33
Improving integrated care in chronic kidney failure patients with a standard-based interoperability framework. ( 25160260 )
2014
34
Understanding discordant meta-analyses of convective dialytic therapies for chronic kidney failure. ( 24856616 )
2014
35
Low estimated glomerular filtration rate and chronic kidney failure following liver transplant: a retrospective cohort study. ( 23897230 )
2013
36
Effectiveness of a nurse-led intensive educational programme on chronic kidney failure patients with hyperphosphataemia: randomised controlled trial. ( 23480506 )
2013
37
Understanding iron: promoting its safe use in patients with chronic kidney failure treated by hemodialysis. ( 23375852 )
2013
38
Micromolecular multiple myeloma with chronic kidney failure in a young female patient on continuous hemodialysis. ( 23529328 )
2013
39
Convective therapies versus low-flux hemodialysis for chronic kidney failure: a meta-analysis of randomized controlled trials. ( 24081858 )
2013
40
Activities of lipogenic enzymes in subcutaneous adipose tissue are not increased in patients with chronic kidney failure. ( 23160012 )
2013
41
Non-albuminuric renal disease among subjects with advanced stages of chronic kidney failure related to type 2 diabetes mellitus. ( 24059817 )
2013
42
Changes in bone matrix mineralization after growth hormone treatment in children and adolescents with chronic kidney failure treated by dialysis: a paired biopsy study. ( 23465957 )
2013
43
Comment on the question 'Are the aims of the K/DOQI guidelines for mineral metabolism disorders in predialysis chronic kidney failure unachievable or inadequate?'. ( 23712231 )
2013
44
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. ( 22772369 )
2012
45
High-flux and low-flux dialysis membranes and levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in children with chronic kidney failure. ( 22976263 )
2012
46
Ask the doctors. I am 71 years old, have chronic kidney failure, and am on dialysis. I know my overall outlook is not good, and I wonder whether it is worth it to take a statin to control my cholesterol. ( 23476941 )
2012
47
ECG of the month. Electrocardiogram in a man with chronic kidney failure. ECG is abnormal and indicative of heart disease. ( 23362595 )
2012
48
Paraoxonase 1 in chronic kidney failure. ( 22523692 )
2012
49
Peginesatide (Omontys) for anemia in chronic kidney failure. ( 22683926 )
2012
50
Successful treatment of peritonitis by C. bertholletiae in a chronic kidney failure patient on continuous ambulatory peritoneal dialysis after kidney rejection. ( 22584986 )
2012

Variations for Chronic Kidney Failure

ClinVar genetic disease variations for Chronic Kidney Failure:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MKS1 NM_017777.3(MKS1): c.1115_1117delCCT (p.Ser372del) deletion Pathogenic rs754279998 GRCh37 Chromosome 17, 56285514: 56285516
2 PKD2 NM_000297.3(PKD2): c.357_364delCCCGGGCAinsTAGGACG (p.Pro120Argfs) indel Pathogenic rs1057518797 GRCh38 Chromosome 4, 88008090: 88008097

Expression for Chronic Kidney Failure

Search GEO for disease gene expression data for Chronic Kidney Failure.

Pathways for Chronic Kidney Failure

GO Terms for Chronic Kidney Failure

Cellular components related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ACE AGT ALB B2M CRP CST3
2 endoplasmic reticulum lumen GO:0005788 9.63 ALB B2M CST3 FGF23 INS