CRF
MCID: CHR089
MIFTS: 68

Chronic Kidney Failure (CRF) malady

Nephrological category

Summaries for Chronic Kidney Failure

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 You have two kidneys, each about the size of your fist. their main job is to filter wastes and excess water out of your blood to make urine. they also keep the body's chemical balance, help control blood pressure, and make hormones. chronic kidney disease (ckd) means that your kidneys are damaged and can't filter blood as they should. this damage can cause wastes to build up in your body. it can also cause other problems that can harm your health. diabetes and high blood pressure are the most common causes of ckd. treatment may include medicines to lower blood pressure, control blood glucose, and lower blood cholesterol. ckd can get worse over time. ckd may lead to kidney failure. the only treatment options for kidney failure are dialysis or a kidney transplantation. you can take steps to keep your kidneys healthier longer: choose foods with less salt (sodium) keep your blood pressure below 130/80 keep your blood glucose in the target range, if you have diabetes nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Chronic Kidney Failure, also known as chronic renal failure syndrome, is related to vascular disease and metabolic acidosis. An important gene associated with Chronic Kidney Failure is APOC2 (apolipoprotein C-II), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). The drugs bumetanide and calcium carbonate and the compounds glutamate and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and renal/urinary system.

Wikipedia:64 Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

Aliases & Classifications for Chronic Kidney Failure

Sources:
8Disease Ontology, 31LifeMap Discovery™, 45Novoseek, 34MedlinePlus, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

chronic kidney failure 8 31
chronic renal failure syndrome 8
chronic kidney insufficiency 61
renal failure - chronic 8
kidney failure, chronic 61
chronic kidney disease 34
chronic renal disease 8
renal failure chronic 45
crf 8


External Ids:

Disease Ontology8 DOID:784
MeSH35 D007676
ICD9CM27 585.6
ICD1025 N18

Related Diseases for Chronic Kidney Failure

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Chronic Kidney Failure family:

acute kidney failure kidney disease

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 418)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease31.2HMGCR, NR1H2, LPL, APOC2, SOD1
2metabolic acidosis30.8ALB, REN, B2M
3deficiency anemia30.7ALB, TTR, EPO, CD79A, B2M, LPL
4fatty liver disease30.6LEP
5iron deficiency anemia30.6EPO, LTF, TF
6short stature30.4LEP
7uremia30.4ALB, LEP, EPO, VDR, B2M, LPL
8nephrolithiasis30.3VDR
9peripheral vascular disease30.3ALB, CD79A
10arteriosclerosis30.3HMGCR, LPL, SOD1
11hepatitis c30.2ALB, HMGCR, LPL, TF
12acute myocardial infarction30.2HMGCR
13aplastic anemia30.2FAN1
14lupus nephritis30.2ALB, CD79A
15coronary heart disease30.2HMGCR, LEP, LPL, APOC2, APOC3
16hypertriglyceridemia30.2HMGCR, LEP, LPL, APOC2, APOC3
17hyperhomocysteinemia30.2ALB, TTR, SOD1
18amenorrhea30.2LEP
19sepsis30.2ALB, TTR, LTF, LPL, CALCA
20renal osteodystrophy30.0VDR, CALCA
21nephritis30.0ALB, CD79A, B2M
22acute kidney failure30.0ALB, HMGCR, REN, B2M
23focal segmental glomerulosclerosis30.0ALB, HMGCR, REN, CD79A
24amyloidosis30.0ALB, TTR, CD79A, B2M, LPL
25arthritis30.0ALB, PTGS2, HMGCR, LEP, VDR, LTF
26lipoprotein lipase deficiency30.0LPL
27growth hormone deficiency30.0LEP
28thalassemia30.0EPO, TF
29sickle cell disease30.0EPO, TF
30anorexia nervosa30.0TTR, LEP
31asthma30.0CD79A, VDR, NR1H2
32acute pancreatitis30.0LPL, APOC2, SOD1
33amyloidosis, secondary30.0TTR, B2M
34vasculitis30.0ALB, CD79A, LTF
35cushing's syndrome30.0REN
36glucose intolerance30.0LEP, LPL, APOC2
37tuberculosis30.0ALB, CD79A, VDR
38autonomic neuropathy30.0ALB, TTR, REN, EPO
39hepatitis b30.0ALB, CD79A, VDR, LTF
40pancreatitis, chronic30.0TTR, LTF, LPL, APOC2, SOD1
41primary biliary cirrhosis29.9ALB, CD79A, VDR, LTF, NR1H2
42osteoporosis29.9HMGCR, LEP, CYP27B1, VDR, NR1H2, CALCA
43type 1 diabetes29.9ALB, LEP, CYP27B1, CD79A, VDR, B2M
44osteitis fibrosa29.9B2M
45atherosclerosis29.9ALB, PTGS2, HMGCR, LEP, NR1H2, LPL
46diabetic nephropathy29.9ALB, HMGCR, REN, EPO, NR1H2, B2M
47insulin resistance29.9ALB, HMGCR, TTR, LEP, NR1H2, LPL
48hemoglobin d disease10.6
49hemoglobin c disease10.6
50kidney hypertrophy10.5

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to chronic kidney failure

Clinical Features for Chronic Kidney Failure

Drugs & Therapeutics for Chronic Kidney Failure

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Kidney Failure

Drug clinical trials:

Search ClinicalTrials for Chronic Kidney Failure

Search NIH Clinical Center for Chronic Kidney Failure

Search CenterWatch for Chronic Kidney Failure

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Kidney Failure

Anatomical Context for Chronic Kidney Failure

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 KidneyProximal TubuleProximal Tubule Cells Potential therapeutic candidate, affected by disease
4 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Chronic Kidney Failure or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Chronic Kidney Failure

Sources:
51PubMed
See all sources

Articles related to Chronic Kidney Failure:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Convective Versus Diffusive Dialysis Therapies for Chronic Kidney Failure: An Updated Systematic Review of Randomized Controlled Trials. (24434188)
2014
2
Polycystic kidney disease and chronic renal failure in tuberous sclerosis. (24092520)
2013
3
Effectiveness of a nurse-led intensive educational programme on chronic kidney failure patients with hyperphosphataemia: randomised controlled trial. (23480506)
2013
4
Comment on the question 'Are the aims of the K/DOQI guidelines for mineral metabolism disorders in predialysis chronic kidney failure unachievable or inadequate?'. (23712231)
2013
5
Activities of lipogenic enzymes in subcutaneous adipose tissue are not increased in patients with chronic kidney failure. (23160012)
2013
6
Micromolecular multiple myeloma with chronic kidney failure in a young female patient on continuous hemodialysis. (23529328)
2013
7
Tissue Doppler-derived E/e' ratio as a parameter for assessing diastolic heart failure and as a predictor of mortality in patients with chronic kidney disease. (23345995)
2013
8
Paraoxonase 1 in chronic kidney failure. (22523692)
2012
9
ECG of the month. Electrocardiogram in a man with chronic kidney failure. ECG is abnormal and indicative of heart disease. (23362595)
2012
10
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. (22772369)
2012
11
Epidemiology and survival of the five stages of chronic kidney disease in a systolic heart failure population. (20484366)
2010
12
Etanercept treatment in rheumatoid arthritis patients with chronic kidney failure on predialysis. (19705121)
2010
13
Induction of chronic kidney failure in a long-term peritoneal exposure model in the rat: effects on functional and structural peritoneal alterations. (20421431)
2010
14
Graft inflammation and histologic indicators of kidney chronic allograft failure: low-expressing interleukin-10 genotypes cannot be ignored. (20622753)
2010
15
Negative effects of chronic kidney failure on lung function and functional capacity. (20464163)
2010
16
The correction of anemia in patients with the combination of chronic kidney disease and congestive heart failure may prevent progression of both conditions. (18670732)
2009
17
Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. (18446719)
2008
18
Recombinant human Epo treatment: beneficial in chronic kidney disease, chronic heart failure, or both? Editorial to: "Correction of anemia with erythropoietin in chronic kidney disease (stage 3 or 4): effects on cardiac performance by Pappas et al.". (18219567)
2008
19
Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study. (17261405)
2007
20
Combined therapy with L-carnitine and erythropoietin of anemia in chronic kidney failure patients undergoing hemodialysis]. (17642201)
2007
21
Statins and cardiovascular risk reduction in patients with chronic kidney disease and end-stage renal failure. (17383281)
2007
22
Arteriosclerotic changes in the myocardium, lung, and kidney in dogs with chronic congestive heart failure and myxomatous mitral valve disease. (16844549)
2006
23
Cardiovascular disease in chronic kidney failure: the role of VDR activators. (16555680)
2006
24
Statins in patients with kidney failure: efficacy, tolerance, and prescription guidelines in patients with chronic kidney disease and renal transplant]. (16493350)
2006
25
Fluvastatin in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation. (15957541)
2005
26
Replicative senescence in patients with chronic kidney failure. (16336562)
2005
27
Therapy insight: congestive heart failure, chronic kidney disease and anemia, the cardio-renal-anemia syndrome. (16265380)
2005
28
Cardiovascular disease in chronic kidney failure: is there a role for vitamin D analogs? (15816500)
2005
29
The phenomenon of altered risk factor patterns or reverse epidemiology in persons with advanced chronic kidney failure. (15941874)
2005
30
State-specific trends in chronic kidney failure--United States, 1990-2001. (15470324)
2004
31
Possible relation of leptin with kidney and chronic renal failure]. (15265449)
2004
32
Lipoprotein disorders in chronic kidney failure, nephrotic syndrome and dialysis]. (12679979)
2002
33
Modes of intensive therapy for arterial hypertension in children with terminal chronic kidney failure]. (12180062)
2002
34
Chronic renal failure in a patient with Sotos syndrome due to autosomal dominant polycystic kidney disease. (12074220)
2002
35
Neonatal chronic kidney failure associated with cyclo-oxygenase-2 inhibitors administered during pregnancy]. (11455321)
2001
36
Severely reduced production of klotho in human chronic renal failure kidney. (11162628)
2001
37
Hepatitis C viral in patients with terminal chronic kidney failure. I. Prevalence]. (10953607)
2000
38
Lipoproteins and vascular changes in chronic kidney failure. (11068644)
2000
39
Case of early pronounced anemia and its effective treatment with human recombinant erythropoietin in a female patient with polycystic kidney in a conservative stage of chronic renal failure]. (10420463)
1999
40
Pathophysiological role of leptin in patients with chronic renal failure, in kidney transplant patients, in patients with essential hypertension, and in pregnant women with preeclampsia. (9950182)
1999
41
Reasons for producing guidelines on anemia of chronic renal failure: dialysis outcome quality initiative of the National Kidney Foundation. (9894755)
1998
42
Proteinuria, hypertension and chronic renal failure in X-linked Kallmann's syndrome, a defined genetic cause of solitary functioning kidney. (9719154)
1998
43
The effect of angiotensin-converting enzyme inhibitors on left ventricular hypertrophy in patients with chronic glomerulonephritis and pronounced kidney failure]. (9297267)
1997
44
Chronic renal failure secondary to 2,8-dihydroxyadenine deposition: the first report of recurrence in a kidney transplant. (8023815)
1994
45
The insulin therapy of patients with terminal chronic kidney failure]. (8067036)
1994
46
Application of recombinant human erythropoietin in patients with polycystic kidney disease and chronic renal failure. (1339766)
1992
47
Determination of lactoferrin in the diagnosis of pancreatopathy in patients with chronic kidney failure]. (1561772)
1992
48
Vasopressin-dependent kidney hypertrophy: role of urinary concentration in protein-induced hypertrophy and in the progression of chronic renal failure. (2042645)
1991
49
Does chronic kidney failure lead to mental failure? A neuropsychologic survey of self-sufficient outpatients. (6797387)
1981
50
On renal failure complicating surgical diseases (laparotomy etc.), with special regard to conservative treatment, and the need for the artificial kidney (dialyser, ultrafilter) in rational renal therapy; acute tubular nephritis, chronic pyelonephritis and prostatic hypertrophy with urinary retention. (14398036)
1954

Genetic Variations for Chronic Kidney Failure

Expression for genes affiliated with Chronic Kidney Failure

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Kidney Failure

Search GEO for disease gene expression data for Chronic Kidney Failure.

Pathways for genes affiliated with Chronic Kidney Failure

Sources:
12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Compounds for genes affiliated with Chronic Kidney Failure

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Chronic Kidney Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 243)
idCompoundScoreTop Affiliating Genes
1glutamate4510.6LPL
2pge24510.2PTGS2, REN
3indomethacin45 60 29 1112.9CALCA, LTF, LEP, REN
4captopril45 29 50 60 1113.8CALCA, REN, CD79A, B2M
5norepinephrine45 11 2411.8TTR, LTF, LPL, CALCA
6alpha tocopherol459.8TTR, NR1H2, LPL, TF
7glucose459.8REN, LPL, APOC2, APOC3, CYP27B1
8hydrocortisone45 2 60 1112.7NR1H2, EPO, REN, CALCA, LTF
9thiazide459.6LPL, HMGCR, REN, VDR, CALCA
10ribavirin45 50 1111.5TF, LEP, HMGCR, EPO
11estrogen459.5LTF, CD79A, TTR, APOC3, VDR
12vitamin a45 11 2411.5CYP27B1, VDR, LTF, NR1H2, LPL, APOC3
13ramipril45 1110.5ALB, REN, CD79A, HMGCR
14fenofibrate45 50 1111.5LEP, HMGCR, NR1H2, LPL, APOC3
15telmisartan45 29 1111.3REN, NR1H2, LEP, ALB
16theophylline45 29 11 2412.3B2M, EPO, CD79A, LPL, TTR, HMGCR
17probucol45 1110.2HMGCR, LTF, LPL, SOD1
18phosphorus459.2B2M, VDR, CYP27B1, CALCA, ALB, TTR
19vitamin d459.2CYP27B1, VDR, CD79A, NR1H2, CALCA, LPL
20troglitazone45 29 60 1112.2HMGCR, VDR, NR1H2, LPL, PTGS2
21heparin45 29 11 2412.2APOC2, APOC3, LTF, HMGCR, CD79A, NR1H2
22pmma459.2CALCA, CD79A, LTF, B2M
23tocopherol459.1HMGCR, TTR, LPL, NR1H2, TF, SOD1
24suprofen45 1110.1SOD1, TF, PTGS2, ALB
25carbohydrates459.0TTR, TF, LPL, APOC3, LTF, LEP
26iron45 249.9TF, B2M, PTGS2, TTR, EPO, LTF
2725-hydroxyvitamin d458.9B2M, CALCA, CYP27B1, LEP, TTR, ALB
28vitamin b12458.9CD79A, TTR, EPO, LTF, TF, B2M
29celecoxib45 60 29 50 11 2413.8ALB, PTGS2, HMGCR, REN, EPO
30hyaluronic acid45 249.8LTF, CD79A, LEP, TTR, ALB, B2M
31dexamethasone45 50 29 1111.8LTF, NR1H2, VDR, CD79A, LPL, PTGS2
32methotrexate45 50 1110.7ALB, HMGCR, TF, LEP, EPO, CD79A
33calcitriol45 60 11 2411.7NR1H2, CYP27B1, CALCA, LPL, ALB, B2M
34epinephrine45 11 2410.7TF, CALCA, REN, CD79A, TTR, LEP
35tacrolimus45 50 1110.7TF, ALB, HMGCR, REN, CD79A, VDR
36folate458.6NR1H2, TF, B2M, VDR, CD79A, EPO
37fibrinogen458.5ALB, TTR, LEP, CD79A, APOC3, TF
38betacarotene458.4VDR, SOD1, TF, LPL, NR1H2, CD79A
39prostacyclin458.2HMGCR, PTGS2, LEP, REN, LTF, NR1H2
40n acetylcysteine458.2CD79A, LEP, LTF, PTGS2, HMGCR, TF
41lactate458.0CD79A, EPO, LPL, HMGCR, CALCA, ALB
42ascorbic acid45 248.9SOD1, ALB, TTR, LEP, TF, LTF
43cyclosporin a45 29 609.9B2M, LPL, TF, CALCA, NR1H2, LTF
44cholesterol45 29 11 2410.8B2M, LEP, CYP27B1, REN, NR1H2, TTR
45testosterone45 60 11 2410.8CYP27B1, B2M, TTR, CALCA, APOC3, LPL
46alanine457.8VDR, CD79A, LTF, NR1H2, B2M, TTR
47vegf457.7CALCA, EPO, TF, B2M, HMGCR, LEP
48cysteine457.7SOD1, LTF, APOC2, NR1H2, B2M, VDR
49thyroxine45 248.6CD79A, REN, LEP, VDR, NR1H2, B2M
50creatinine457.2ALB, HMGCR, TTR, LEP, REN, EPO

GO Terms for genes affiliated with Chronic Kidney Failure

Sources:
16Gene Ontology
See all sources

Cellular components related to Chronic Kidney Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spherical high-density lipoprotein particleGO:03436610.1APOC3, APOC2
2intermediate-density lipoprotein particleGO:03436310.0APOC3, APOC2
3chylomicronGO:0426279.9APOC2, APOC3, LPL
4very-low-density lipoprotein particleGO:0343619.9APOC3, APOC2, LPL
5protein complexGO:0432348.5ALB, PTGS2, TTR, SOD1
6extracellular spaceGO:0056157.6CALCA, SOD1, APOC3, APOC2, LPL, B2M
7extracellular regionGO:0055767.1ALB, CALCA, SOD1, APOC3, APOC2, TF

Biological processes related to Chronic Kidney Failure according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid metabolic processGO:04583310.4APOC3, APOC2
2negative regulation of very-low-density lipoprotein particle clearanceGO:01091610.4APOC3, APOC2
3chylomicron remodelingGO:03437110.4APOC2, LPL
4chylomicron remnant clearanceGO:03438210.4APOC2, APOC3
5negative regulation of receptor-mediated endocytosisGO:04826110.3APOC2, APOC3
6negative regulation of calcium ion transport into cytosolGO:01052310.3CALCA, EPO
7positive regulation of vitamin D 24-hydroxylase activityGO:01098010.3VDR, CYP27B1
8very-low-density lipoprotein particle remodelingGO:03437210.3LPL, APOC2
9positive regulation of fatty acid biosynthetic processGO:04572310.2NR1H2, APOC2
10triglyceride homeostasisGO:07032810.2APOC3, APOC2, LPL
11positive regulation of lipoprotein lipase activityGO:05100610.2APOC2, NR1H2
12cholesterol homeostasisGO:04263210.2APOC3, APOC2, NR1H2
13positive regulation of keratinocyte differentiationGO:04561810.0VDR, CYP27B1
14phospholipid effluxGO:03370010.0APOC2, APOC3
15negative regulation of smooth muscle contractionGO:04598610.0PTGS2, CALCA
16retinoid metabolic processGO:00152310.0APOC3, APOC2, LPL, TTR
17phototransduction, visible lightGO:0076039.9APOC3, APOC2, LPL, TTR
18lipoprotein metabolic processGO:0421579.8APOC3, APOC2, LPL, ALB
19decidualizationGO:0466979.8PTGS2, CYP27B1, VDR
20response to nutrientGO:0075849.8APOC3, HMGCR, ALB
21response to vitamin DGO:0332809.8PTGS2, CYP27B1
22response to lipopolysaccharideGO:0324969.7PTGS2, REN, CYP27B1, EPO
23embryo implantationGO:0075669.5CALCA, SOD1, EPO, PTGS2
24regulation of blood pressureGO:0082179.1PTGS2, LEP, REN, SOD1, CALCA
25response to drugGO:0424939.0SOD1, APOC3, APOC2, LPL, B2M, PTGS2
26platelet degranulationGO:0025769.0SOD1, TF, ALB
27small molecule metabolic processGO:0442818.5APOC3, APOC2, LPL, CYP27B1, HMGCR, PTGS2

Molecular functions related to Chronic Kidney Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipase inhibitor activityGO:0551029.8APOC2, APOC3
2hormone activityGO:0051799.3TTR, LEP, EPO, CALCA
3protein bindingGO:0055156.9TTR, ALB, CALCA, SOD1, FAN1, TF

Products for genes affiliated with Chronic Kidney Failure

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Kidney Failure

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet