CRF
MCID: CHR089
MIFTS: 66

Chronic Kidney Failure (CRF) malady

Genetic diseases, Nephrological diseases, Rare diseases, Fetal diseases categories
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Summaries for Chronic Kidney Failure

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MedlinePlus:33 You have two kidneys, each about the size of your fist. their main job is to filter wastes and excess water out of your blood to make urine. they also keep the body's chemical balance, help control blood pressure, and make hormones. chronic kidney disease (ckd) means that your kidneys are damaged and can't filter blood as they should. this damage can cause wastes to build up in your body. it can also cause other problems that can harm your health. diabetes and high blood pressure are the most common causes of ckd. treatment may include medicines to lower blood pressure, control blood glucose, and lower blood cholesterol. ckd can get worse over time. ckd may lead to kidney failure. the only treatment options for kidney failure are dialysis or a kidney transplantation. you can take steps to keep your kidneys healthier longer: choose foods with less salt (sodium) keep your blood pressure below 130/80 keep your blood glucose in the target range, if you have diabetes nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Chronic Kidney Failure, also known as chronic renal failure syndrome, is related to hypertriglyceridemia and myocardial infarction. An important gene associated with Chronic Kidney Failure is FAN1 (FANCD2/FANCI-associated nuclease 1), and among its related pathways are Diseases associated with visual transduction and Lipoprotein metabolism. The drugs cholecalciferol and calcium carbonate and the compounds gemfibrozil and triacylglycerol have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow.

Wikipedia:65 Chronic kidney disease (CKD), also known as chronic renal disease (CRD), is a progressive loss in renal... more...

Aliases & Classifications for Chronic Kidney Failure

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Chronic Kidney Failure, Aliases & Descriptions:

Name: Chronic Kidney Failure 30 8
Chronic Renal Failure Syndrome 8 62
Chronic Kidney Insufficiency 62
Renal Failure - Chronic 8
Kidney Failure, Chronic 62
 
Chronic Kidney Disease 33
Chronic Renal Disease 8
Renal Failure Chronic 44
Crf 8


Classifications:



External Ids:

Disease Ontology8 DOID:784
MeSH34 D007676
ICD9CM27 585.6
ICD1025 N18

Related Diseases for Chronic Kidney Failure

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Diseases in the Chronic Kidney Failure family:

Acute Kidney Failure Kidney Disease
Renal Infectious Disease Ren-Related Kidney Disease
Renal Dysplasia

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1hypertriglyceridemia30.3APOC2, APOC3
2myocardial infarction30.2APOC3, REN
3type 2 diabetes mellitus30.0APOC2, APOC3
4proteinuria29.6REN, APOC2, APOC3
5diabetes mellitus29.4CYP27B1, APOC3, APOC2, REN
6metabolic acidosis10.5
7vascular disease10.5
8neuronitis10.5
9gout10.4
10systolic heart failure10.4
11calciphylaxis10.4
12deficiency anemia10.4
13iron deficiency anemia10.4
14alzheimer's disease10.3
15renal cell carcinoma10.3
16diastolic heart failure10.3
17polycystic kidney disease10.3
18artery disease10.3
19sagliker syndrome10.3
20peripheral vascular disease10.3
21liver disease10.3
22fatty liver disease10.3
23restless legs syndrome10.3
24sleep apnea10.3
25uremia10.3
26short stature10.3
27blindness10.3
28hepatitis10.2
29hypertension10.2
30hepatitis c10.2
31nephrocalcinosis10.2
32peritonitis10.2
33focal segmental glomerulosclerosis10.2
34nephrolithiasis10.2
35fabry disease10.2
36obstructive sleep apnea10.2
37familial juvenile hyperuricemic nephropathy10.2
38cerebritis10.2
39arteriosclerosis10.2
40essential hypertension10.2
41glomerulosclerosis10.2
42hypothyroidism10.2
43neuropathy10.2
44testicular cancer10.2
45nephrogenic systemic fibrosis10.2
46hypoxia10.2
47hyperphosphatemia10.2
48amenorrhea10.1
49anxiety disorder10.1
50familial hypertriglyceridemia10.1APOC2, APOC3

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to chronic kidney failure

Symptoms for Chronic Kidney Failure

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Drugs & Therapeutics for Chronic Kidney Failure

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Drug clinical trials:

Search ClinicalTrials for Chronic Kidney Failure

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Kidney Failure

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Anatomical Context for Chronic Kidney Failure

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MalaCards organs/tissues related to Chronic Kidney Failure:

32
Kidney, Bone, Bone marrow, Heart, Liver, Lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 KidneyProximal TubuleProximal Tubule Cells Potential therapeutic candidate, affected by disease
4 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Chronic Kidney Failure or affiliated genes

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Publications for Chronic Kidney Failure

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Articles related to Chronic Kidney Failure:

(show top 50)    (show all 85)
idTitleAuthorsYear
1
Association of PTH and carotid thickness in patients with chronic kidney failure and secondary hyperparathyroidism. (25317613)
2014
2
Understanding discordant meta-analyses of convective dialytic therapies for chronic kidney failure. (24856616)
2014
3
Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. (24856028)
2014
4
Convective therapies versus low-flux hemodialysis for chronic kidney failure: a meta-analysis of randomized controlled trials. (24081858)
2013
5
Effectiveness of a nurse-led intensive educational programme on chronic kidney failure patients with hyperphosphataemia: randomised controlled trial. (23480506)
2013
6
Comment on the question 'Are the aims of the K/DOQI guidelines for mineral metabolism disorders in predialysis chronic kidney failure unachievable or inadequate?'. (23712231)
2013
7
Activities of lipogenic enzymes in subcutaneous adipose tissue are not increased in patients with chronic kidney failure. (23160012)
2013
8
Changes in bone matrix mineralization after growth hormone treatment in children and adolescents with chronic kidney failure treated by dialysis: a paired biopsy study. (23465957)
2013
9
Micromolecular multiple myeloma with chronic kidney failure in a young female patient on continuous hemodialysis. (23529328)
2013
10
Paraoxonase 1 in chronic kidney failure. (22523692)
2012
11
ECG of the month. Electrocardiogram in a man with chronic kidney failure. ECG is abnormal and indicative of heart disease. (23362595)
2012
12
Ask the doctors. I am 71 years old, have chronic kidney failure, and am on dialysis. I know my overall outlook is not good, and I wonder whether it is worth it to take a statin to control my cholesterol. (23476941)
2012
13
Peginesatide (Omontys) for anemia in chronic kidney failure. (22683926)
2012
14
High-flux and low-flux dialysis membranes and levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in children with chronic kidney failure. (22976263)
2012
15
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. (22772369)
2012
16
Pathology in practice. Chronic kidney failure. (21401426)
2011
17
Etanercept treatment in rheumatoid arthritis patients with chronic kidney failure on predialysis. (19705121)
2010
18
Hemolysis in a patient with alkaptonuria and chronic kidney failure. (20207456)
2010
19
Malnutrition in chronic kidney failure: what is the best diagnostic method to assess?]. (21448521)
2010
20
Induction of chronic kidney failure in a long-term peritoneal exposure model in the rat: effects on functional and structural peritoneal alterations. (20421431)
2010
21
71-year-old man with chronic kidney failure and sudden change of mental status. (19880683)
2009
22
Causes and prevention of protein-energy wasting in chronic kidney failure. (19121473)
2009
23
Genotype 1 hepatitis C virus infection predominates among patients with chronic kidney failure and renal allograft recipients in India. (19937412)
2009
24
Leptin and lipid metabolism in chronic kidney failure. (19148833)
2009
25
How do families adjust to having a child with chronic kidney failure? A systematic review. (18472684)
2008
26
Metabolic disorders in patients with chronic kidney failure. (17298212)
2007
27
Phenylalanine and tyrosine metabolism in chronic kidney failure. (17513431)
2007
28
Vascular calcification in chronic kidney failure: role of vitamin D receptor. (17408120)
2007
29
Combined therapy with L-carnitine and erythropoietin of anemia in chronic kidney failure patients undergoing hemodialysis]. (17642201)
2007
30
Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure. (16871242)
2006
31
Fluvastatin in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation. (15957541)
2005
32
The effects of serum calcium and parathyroid hormone and the interaction between them on blood pressure in normal subjects and in patients with chronic kidney failure. (15648029)
2005
33
Replicative senescence in patients with chronic kidney failure. (16336562)
2005
34
Cardiovascular disease in chronic kidney failure: is there a role for vitamin D analogs? (15816500)
2005
35
State-specific trends in chronic kidney failure--United States, 1990-2001. (15470324)
2004
36
Medical nutrition therapy in chronic kidney failure: integrating clinical practice guidelines. (14993863)
2004
37
A comparison of clinically useful phosphorus binders for patients with chronic kidney failure. (15296504)
2004
38
Lipoprotein disorders in chronic kidney failure, nephrotic syndrome and dialysis]. (12679979)
2002
39
Modes of intensive therapy for arterial hypertension in children with terminal chronic kidney failure]. (12180062)
2002
40
Extraskeletal calcification in patients with chronic kidney failure. (11068650)
2000
41
Relation between parathormone and 1,25-dihydroxyvitamin D3 in chronic kidney failure]. (9750473)
1997
42
The characteristics of disorders in carbohydrate metabolism and insulin and C-peptide secretion in patients with chronic glomerulonephritis in developing chronic kidney failure]. (8771677)
1996
43
The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. (7532880)
1994
44
Iron stores in patients with chronic kidney failure treated with recombinant human erythropoietin]. (8184571)
1994
45
Gastric intramucosal acidosis in patients with chronic kidney failure. (8488469)
1993
46
Effect of hemodialysis on levels of parathormone in blood of patients with chronic kidney failure]. (8249416)
1993
47
Determination of lactoferrin in the diagnosis of pancreatopathy in patients with chronic kidney failure]. (1561772)
1992
48
The treatment of severe arterial hypertension in patients with chronic kidney failure with captopril and beta-adrenoblockaders]. (1871923)
1991
49
Metabolic consequences of feeding a high-carbohydrate, high-fiber diet to diabetic patients with chronic kidney failure. (2841839)
1988
50
Does chronic kidney failure lead to mental failure? A neuropsychologic survey of self-sufficient outpatients. (6797387)
1981

Variations for Chronic Kidney Failure

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Expression for genes affiliated with Chronic Kidney Failure

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Expression patterns in normal tissues for genes affiliated with Chronic Kidney Failure

Search GEO for disease gene expression data for Chronic Kidney Failure.

Pathways for genes affiliated with Chronic Kidney Failure

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Compounds for genes affiliated with Chronic Kidney Failure

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Compounds related to Chronic Kidney Failure according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1gemfibrozil28 44 1111.7APOC2, APOC3
2triacylglycerol449.7APOC2, APOC3
3homocysteine44 2410.6APOC2, APOC3
4methionine449.4APOC2, APOC3
5polyacrylamide449.3APOC3, APOC2
6nacl449.2APOC2, REN
7calcitriol44 61 24 1112.1REN, CYP27B1
8vitamin a44 24 1111.1APOC2, APOC3, CYP27B1
9chloramphenicol44 2 50 1112.0APOC3, CYP27B1
10retinoic acid44 2410.0APOC2, APOC3, CYP27B1
11creatinine448.8APOC3, APOC2, REN
12lipid448.8APOC2, APOC3, CYP27B1
13steroid448.7CYP27B1, APOC3, REN
14cholesterol44 28 24 1111.3REN, APOC2, APOC3, CYP27B1
15glucose448.3CYP27B1, APOC3, APOC2, REN

GO Terms for genes affiliated with Chronic Kidney Failure

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Cellular components related to Chronic Kidney Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:0343639.6APOC3, APOC2
2spherical high-density lipoprotein particleGO:0343669.5APOC3, APOC2
3chylomicronGO:0426279.5APOC3, APOC2
4very-low-density lipoprotein particleGO:0343619.4APOC3, APOC2
5early endosomeGO:0057699.3APOC3, APOC2
6extracellular regionGO:0055768.6APOC3, APOC2, REN
7extracellular spaceGO:0056158.3APOC3, APOC2, REN

Biological processes related to Chronic Kidney Failure according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of very-low-density lipoprotein particle clearanceGO:0109169.7APOC2, APOC3
2negative regulation of lipid metabolic processGO:0458339.7APOC2, APOC3
3chylomicron remnant clearanceGO:0343829.7APOC2, APOC3
4negative regulation of receptor-mediated endocytosisGO:0482619.7APOC2, APOC3
5phospholipid effluxGO:0337009.7APOC3, APOC2
6lipoprotein transportGO:0429539.7APOC2, APOC3
7reverse cholesterol transportGO:0436919.7APOC2, APOC3
8triglyceride homeostasisGO:0703289.6APOC2, APOC3
9cholesterol effluxGO:0333449.6APOC3, APOC2
10lipoprotein metabolic processGO:0421579.6APOC2, APOC3
11retinoid metabolic processGO:0015239.5APOC2, APOC3
12cholesterol homeostasisGO:0426329.5APOC2, APOC3
13phototransduction, visible lightGO:0076039.4APOC3, APOC2
14response to drugGO:0424939.4APOC2, APOC3
15response to lipopolysaccharideGO:0324968.9REN, CYP27B1
16small molecule metabolic processGO:0442818.5APOC2, APOC3, CYP27B1

Molecular functions related to Chronic Kidney Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipase inhibitor activityGO:0551029.4APOC2, APOC3

Products for genes affiliated with Chronic Kidney Failure

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Sources for Chronic Kidney Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet