MCID: CHR089
MIFTS: 57

Chronic Kidney Failure malady

Genetic diseases (common), Nephrological diseases categories

Summaries for Chronic Kidney Failure

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MedlinePlus:32 You have two kidneys, each about the size of your fist. their main job is to filter wastes and excess water out of your blood to make urine. they also keep the body's chemical balance, help control blood pressure, and make hormones. chronic kidney disease (ckd) means that your kidneys are damaged and can't filter blood as they should. this damage can cause wastes to build up in your body. it can also cause other problems that can harm your health. diabetes and high blood pressure are the most common causes of ckd. treatment may include medicines to lower blood pressure, control blood glucose, and lower blood cholesterol. ckd can get worse over time. ckd may lead to kidney failure. the only treatment options for kidney failure are dialysis or a kidney transplantation. you can take steps to keep your kidneys healthier longer: choose foods with less salt (sodium) keep your blood pressure below 130/80 keep your blood glucose in the target range, if you have diabetes nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Chronic Kidney Failure, also known as chronic kidney disease, is related to coronary artery disease and hypertriglyceridemia. An important gene associated with Chronic Kidney Failure is FAN1 (FANCD2/FANCI-associated nuclease 1), and among its related pathways are Diseases associated with visual transduction and Lipoprotein metabolism. The drugs bumetanide and calcium carbonate and the compounds gemfibrozil and triacylglycerol have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow.

Wikipedia:63 Chronic kidney disease (CKD), also known as chronic renal disease, is a progressive loss in renal... more...

Aliases & Classifications for Chronic Kidney Failure

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Chronic Kidney Failure, Aliases & Descriptions:

Name: Chronic Kidney Failure 30 9
Chronic Kidney Disease 32 3
Chronic Renal Failure Syndrome 9
Chronic Kidney Insufficiency 60
Renal Failure - Chronic 9
 
Kidney Failure, Chronic 60
Chronic Kidney Diseases 60
Chronic Renal Disease 9
Renal Failure Chronic 43
Crf 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:784
ICD9CM27 585.6
MeSH33 D007676
ICD1025 N18

Related Diseases for Chronic Kidney Failure

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Diseases in the Kidney Disease family:

Acute Kidney Failure chronic kidney failure
Renal Infectious Disease Ren-Related Kidney Disease

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 295)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease30.5APOC3, APOC2
2hypertriglyceridemia30.3APOC2, APOC3
3myocardial infarction30.2REN, APOC3
4proteinuria29.6APOC3, APOC2, REN
5metabolic acidosis10.5
6vascular disease10.5
7neuronitis10.5
8gout10.5
9systolic heart failure10.4
10calciphylaxis10.4
11artery disease10.4
12renal cell carcinoma10.4
13deficiency anemia10.4
14iron deficiency anemia10.4
15polycystic kidney disease10.4
16sagliker syndrome10.4
17diastolic heart failure10.3
18peritonitis10.3
19peripheral vascular disease10.3
20liver disease10.3
21nephrolithiasis10.3
22fatty liver disease10.3
23restless legs syndrome10.3
24hypothyroidism10.3
25sleep apnea10.3
26uremia10.3
27blindness10.3
28hepatitis10.2
29hepatitis c10.2
30nephrocalcinosis10.2
31kidney disease10.2
32fabry disease10.2
33focal segmental glomerulosclerosis10.2
34arteriolosclerosis10.2
35obstructive sleep apnea10.2
36cerebritis10.2
37arteriosclerosis10.2
38glomerulosclerosis10.2
39neuropathy10.2
40testicular cancer10.2
41nephrogenic systemic fibrosis10.2
42hypoxia10.2
43hyperphosphatemia10.2
44amenorrhea10.1
45anxiety disorder10.1
46congenital anomalies of kidney and urinary tract10.1
47pulmonary function10.1
48papillorenal syndrome10.1
49aplastic anemia10.1
50acute myocardial infarction10.1

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to chronic kidney failure

Symptoms for Chronic Kidney Failure

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Drugs & Therapeutics for Chronic Kidney Failure

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Drug clinical trials:

Search ClinicalTrials for Chronic Kidney Failure

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Kidney Failure

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Anatomical Context for Chronic Kidney Failure

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MalaCards organs/tissues related to Chronic Kidney Failure:

31
Kidney, Bone, Bone marrow, Heart, Liver, Lung, Neutrophil

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 KidneyProximal TubuleProximal Tubule Cells Potential therapeutic candidate, affected by disease
4 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Chronic Kidney Failure or affiliated genes

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Publications for Chronic Kidney Failure

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Articles related to Chronic Kidney Failure:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
Peritoneal dialysis in China: meeting the challenge of chronic kidney failure. (25446022)
2015
2
Association of PTH and carotid thickness in patients with chronic kidney failure and secondary hyperparathyroidism. (25317613)
2014
3
Understanding discordant meta-analyses of convective dialytic therapies for chronic kidney failure. (24856616)
2014
4
Patient engagement and patient-centred care in the management of advanced chronic kidney disease and chronic kidney failure. (25780613)
2014
5
Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. (24856028)
2014
6
Convective therapies versus low-flux hemodialysis for chronic kidney failure: a meta-analysis of randomized controlled trials. (24081858)
2013
7
Effectiveness of a nurse-led intensive educational programme on chronic kidney failure patients with hyperphosphataemia: randomised controlled trial. (23480506)
2013
8
Comment on the question 'Are the aims of the K/DOQI guidelines for mineral metabolism disorders in predialysis chronic kidney failure unachievable or inadequate?'. (23712231)
2013
9
Activities of lipogenic enzymes in subcutaneous adipose tissue are not increased in patients with chronic kidney failure. (23160012)
2013
10
Changes in bone matrix mineralization after growth hormone treatment in children and adolescents with chronic kidney failure treated by dialysis: a paired biopsy study. (23465957)
2013
11
Micromolecular multiple myeloma with chronic kidney failure in a young female patient on continuous hemodialysis. (23529328)
2013
12
Paraoxonase 1 in chronic kidney failure. (22523692)
2012
13
ECG of the month. Electrocardiogram in a man with chronic kidney failure. ECG is abnormal and indicative of heart disease. (23362595)
2012
14
Ask the doctors. I am 71 years old, have chronic kidney failure, and am on dialysis. I know my overall outlook is not good, and I wonder whether it is worth it to take a statin to control my cholesterol. (23476941)
2012
15
Peginesatide (Omontys) for anemia in chronic kidney failure. (22683926)
2012
16
High-flux and low-flux dialysis membranes and levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in children with chronic kidney failure. (22976263)
2012
17
Pathology in practice. Chronic kidney failure. (21401426)
2011
18
Etanercept treatment in rheumatoid arthritis patients with chronic kidney failure on predialysis. (19705121)
2010
19
Hemolysis in a patient with alkaptonuria and chronic kidney failure. (20207456)
2010
20
Malnutrition in chronic kidney failure: what is the best diagnostic method to assess?]. (21448521)
2010
21
Induction of chronic kidney failure in a long-term peritoneal exposure model in the rat: effects on functional and structural peritoneal alterations. (20421431)
2010
22
71-year-old man with chronic kidney failure and sudden change of mental status. (19880683)
2009
23
Causes and prevention of protein-energy wasting in chronic kidney failure. (19121473)
2009
24
Genotype 1 hepatitis C virus infection predominates among patients with chronic kidney failure and renal allograft recipients in India. (19937412)
2009
25
Leptin and lipid metabolism in chronic kidney failure. (19148833)
2009
26
How do families adjust to having a child with chronic kidney failure? A systematic review. (18472684)
2008
27
Metabolic disorders in patients with chronic kidney failure. (17298212)
2007
28
Phenylalanine and tyrosine metabolism in chronic kidney failure. (17513431)
2007
29
Vascular calcification in chronic kidney failure: role of vitamin D receptor. (17408120)
2007
30
Combined therapy with L-carnitine and erythropoietin of anemia in chronic kidney failure patients undergoing hemodialysis]. (17642201)
2007
31
Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure. (16871242)
2006
32
Cardiovascular disease in chronic kidney failure: the role of VDR activators. (16555680)
2006
33
Fluvastatin in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation. (15957541)
2005
34
The effects of serum calcium and parathyroid hormone and the interaction between them on blood pressure in normal subjects and in patients with chronic kidney failure. (15648029)
2005
35
Replicative senescence in patients with chronic kidney failure. (16336562)
2005
36
State-specific trends in chronic kidney failure--United States, 1990-2001. (15470324)
2004
37
Medical nutrition therapy in chronic kidney failure: integrating clinical practice guidelines. (14993863)
2004
38
A comparison of clinically useful phosphorus binders for patients with chronic kidney failure. (15296504)
2004
39
Lipoprotein disorders in chronic kidney failure, nephrotic syndrome and dialysis]. (12679979)
2002
40
Modes of intensive therapy for arterial hypertension in children with terminal chronic kidney failure]. (12180062)
2002
41
Extraskeletal calcification in patients with chronic kidney failure. (11068650)
2000
42
Relation between parathormone and 1,25-dihydroxyvitamin D3 in chronic kidney failure]. (9750473)
1997
43
The characteristics of disorders in carbohydrate metabolism and insulin and C-peptide secretion in patients with chronic glomerulonephritis in developing chronic kidney failure]. (8771677)
1996
44
The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. (7532880)
1994
45
Iron stores in patients with chronic kidney failure treated with recombinant human erythropoietin]. (8184571)
1994
46
Gastric intramucosal acidosis in patients with chronic kidney failure. (8488469)
1993
47
Effect of hemodialysis on levels of parathormone in blood of patients with chronic kidney failure]. (8249416)
1993
48
The treatment of severe arterial hypertension in patients with chronic kidney failure with captopril and beta-adrenoblockaders]. (1871923)
1991
49
Metabolic consequences of feeding a high-carbohydrate, high-fiber diet to diabetic patients with chronic kidney failure. (2841839)
1988
50
Does chronic kidney failure lead to mental failure? A neuropsychologic survey of self-sufficient outpatients. (6797387)
1981

Variations for Chronic Kidney Failure

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Expression for genes affiliated with Chronic Kidney Failure

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Search GEO for disease gene expression data for Chronic Kidney Failure.

Pathways for genes affiliated with Chronic Kidney Failure

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Compounds for genes affiliated with Chronic Kidney Failure

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Compounds related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

(show all 15)
idCompoundScoreTop Affiliating Genes
1gemfibrozil28 43 1211.7APOC2, APOC3
2triacylglycerol439.7APOC2, APOC3
3homocysteine43 2410.6APOC2, APOC3
4methionine439.4APOC2, APOC3
5polyacrylamide439.3APOC3, APOC2
6nacl439.2APOC2, REN
7calcitriol43 59 24 1212.1REN, CYP27B1
8vitamin a43 24 1211.1APOC2, APOC3, CYP27B1
9chloramphenicol43 2 49 1212.0APOC3, CYP27B1
10retinoic acid43 2410.0APOC2, APOC3, CYP27B1
11creatinine438.8APOC3, APOC2, REN
12lipid438.8APOC2, APOC3, CYP27B1
13steroid438.7CYP27B1, APOC3, REN
14cholesterol43 28 24 1211.3REN, APOC2, APOC3, CYP27B1
15glucose438.3CYP27B1, APOC3, APOC2, REN

GO Terms for genes affiliated with Chronic Kidney Failure

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Cellular components related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:00343639.6APOC3, APOC2
2spherical high-density lipoprotein particleGO:00343669.5APOC3, APOC2
3chylomicronGO:00426279.5APOC3, APOC2
4very-low-density lipoprotein particleGO:00343619.4APOC3, APOC2
5early endosomeGO:00057699.3APOC3, APOC2
6extracellular regionGO:00055768.6APOC3, APOC2, REN
7extracellular spaceGO:00056158.3APOC3, APOC2, REN

Biological processes related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of very-low-density lipoprotein particle clearanceGO:00109169.7APOC2, APOC3
2negative regulation of lipid metabolic processGO:00458339.7APOC2, APOC3
3chylomicron remnant clearanceGO:00343829.7APOC2, APOC3
4negative regulation of receptor-mediated endocytosisGO:00482619.7APOC2, APOC3
5phospholipid effluxGO:00337009.7APOC3, APOC2
6lipoprotein transportGO:00429539.7APOC2, APOC3
7reverse cholesterol transportGO:00436919.7APOC2, APOC3
8triglyceride homeostasisGO:00703289.6APOC2, APOC3
9cholesterol effluxGO:00333449.6APOC3, APOC2
10lipoprotein metabolic processGO:00421579.6APOC2, APOC3
11retinoid metabolic processGO:00015239.5APOC2, APOC3
12cholesterol homeostasisGO:00426329.5APOC2, APOC3
13phototransduction, visible lightGO:00076039.4APOC3, APOC2
14response to drugGO:00424939.4APOC2, APOC3
15response to lipopolysaccharideGO:00324968.9REN, CYP27B1
16small molecule metabolic processGO:00442818.5APOC2, APOC3, CYP27B1

Molecular functions related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipase inhibitor activityGO:00551029.4APOC2, APOC3

Products for genes affiliated with Chronic Kidney Failure

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Sources for Chronic Kidney Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet