CKD
MCID: CHR089
MIFTS: 66

Chronic Kidney Failure (CKD) malady

Categories: Nephrological diseases, Genetic diseases

Aliases & Classifications for Chronic Kidney Failure

Aliases & Descriptions for Chronic Kidney Failure:

Name: Chronic Kidney Failure 38 12
Chronic Kidney Disease 12 41 3 14
Renal Failure - Chronic 12 29
Kidney Failure, Chronic 42 69
Chronic Renal Disease 12 14
Ckd 12 3
Chronic Renal Failure Syndrome 12
Chronic Kidney Diseases 69
Renal Failure Chronic 52
Crf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:784
ICD10 33 N18.9 N18
ICD9CM 35 585.6
MeSH 42 D007676
NCIt 47 C9438
UMLS 69 C0022661

Summaries for Chronic Kidney Failure

MedlinePlus : 41 you have two kidneys, each about the size of your fist. their main job is to filter wastes and excess water out of your blood to make urine. they also keep the body's chemical balance, help control blood pressure, and make hormones. chronic kidney disease (ckd) means that your kidneys are damaged and can't filter blood as they should. this damage can cause wastes to build up in your body. it can also cause other problems that can harm your health. diabetes and high blood pressure are the most common causes of ckd. the kidney damage occurs slowly over many years. many people don't have any symptoms until their kidney disease is very advanced. blood and urine tests are the only way to know if you have kidney disease. treatment may include medicines to lower blood pressure, control blood glucose, and lower blood cholesterol. ckd can get worse over time. ckd may lead to kidney failure. the only treatment options for kidney failure are dialysis or a kidney transplantation. you can take steps to keep your kidneys healthier longer: choose foods with less salt (sodium) keep your blood pressure below 130/80 keep your blood glucose in the target range, if you have diabetes nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Chronic Kidney Failure, also known as chronic kidney disease, is related to pyelonephritis and end stage renal failure, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Failure is MKS1 (Meckel Syndrome, Type 1), and among its related pathways/superpathways are Folate Metabolism and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Capsaicin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 71 Chronic kidney disease (CKD), also known as chronic renal disease, is progressive loss in kidney... more...

Related Diseases for Chronic Kidney Failure

Diseases in the Kidney Disease family:

Acute Kidney Failure Chronic Kidney Failure
Renal Infectious Disease Ren-Related Kidney Disease

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
id Related Disease Score Top Affiliating Genes
1 pyelonephritis 29.6 ACE CRP REN
2 end stage renal failure 11.8
3 nephrocalcinosis 11.0
4 dent disease 10.7
5 uremic pruritus 10.7
6 hypouricemia, renal, 2 10.6
7 hypouricemia, renal 10.6
8 phaeochromocytoma 10.4 ALB TTR
9 hypotrichosis simplex 10.4 ACE REN
10 male genital organ stricture 10.4 ALB TF TTR
11 female infertility of uterine origin 10.4 ALB TF TTR
12 cerebral sarcoidosis 10.4 ALB EPO TF
13 tmem231-related joubert syndrome 10.4 INS TF VDR
14 choriodal dystrophy, central areolar 2 10.4 B2M TF TTR
15 bacteriuria 10.4 B2M TF TTR
16 dientamoebiasis 10.4 ACE EPO REN
17 basal ganglia cerebrovascular disease 10.4 ALB EPO INS
18 gilles de la tourette syndrome 10.3 ALB B2M
19 hemopericardium 10.3 ALB INS TTR
20 acute infection of pinna 10.3 CRP INS
21 poems syndrome 10.3 CRP EPO TF
22 y chromosome detection 10.3 CYP27B1 PTH VDR
23 focal epithelial hyperplasia 10.3 ALB TF TTR
24 erythema infectiosum 10.3 ALB CRP TTR
25 penile cancer, childhood 10.3 ACE AGT
26 iris disease 10.3 ACE AGT REN
27 hemorrhoid 10.3 B2M CRP REN
28 breast metaplastic carcinoma 10.3 B2M EPO PTH
29 fissured tongue 10.3 ALB EPO INS
30 ehlers-danlos syndrome, periodontal type 1 10.3 ALB TTR
31 glycogen storage disease viii 10.3 B2M CRP REN
32 anaplastic ganglioglioma 10.3 B2M CRP TTR
33 acute necrotizing encephalitis 10.3 ALB B2M REN
34 cascade stomach 10.3 ACE AGT REN
35 paranasal sinus sarcoma 10.3 ALB REN TTR
36 plummer's disease 10.3 ALB B2M CRP
37 hyperuricemic nephropathy, familial juvenile 2 10.3 ACE AGT REN
38 prostate cancer, hereditary, x-linked 2 10.3 CYP27B1 FGF23 VDR
39 bladder sarcoma 10.3 ALB LEP TF TTR
40 eastern equine encephalitis 10.3 ACE AGT REN
41 congenital nystagmus 10.3 ACE ALB B2M REN
42 hyperinsulinemic hypoglycemia, familial, 3 10.3 ACE REN
43 mental retardation hypocupremia hypobetalipoproteinemia 10.3 AGT SOD1 TTR
44 petrositis 10.3 ACE ALB EPO REN
45 flat umbilicus familial 10.3 ACE AGT REN
46 osteochondrodysplasia 10.3 HMGCR PTH VDR
47 uterine ligament serous adenocarcinoma 10.3 ALB B2M INS TTR
48 neurological manifestations of pompe disease 10.3 ALB SOD1
49 blind hypotensive eye 10.3 CRP EPO TF
50 cetp-related hyperalphalipoproteinemia 10.3 ACE AGT INS

Comorbidity relations with Chronic Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 114)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Alcoholic Liver Cirrhosis
Amyloidosis Aplastic Anemia
Bacteremia Benign Essential Hypertension
Benign Hypertensive Renal Disease Benign Renovascular Hypertension
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Myocardial Ischemia
Chronic Rapidly Progressive Glomerulonephritis Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Disseminated Intravascular Coagulation Duodenitis
Encephalopathy Esophageal Candidiasis
Esophageal Disease Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Goodpasture Syndrome
Gout Heart Conduction Disease
Heart Disease Hemolytic-Uremic Syndrome
Hepatic Encephalopathy Hepatorenal Syndrome
Hydronephrosis Hyperparathyroidism
Hypertension, Essential Hypertensive Encephalopathy

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to Chronic Kidney Failure

Symptoms & Phenotypes for Chronic Kidney Failure

UMLS symptoms related to Chronic Kidney Failure:


cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to Chronic Kidney Failure:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 ACE AGT ALB B2M CRP CST3
2 cardiovascular system MP:0005385 10.42 ACE AGT B2M CRP CST3 CYP27B1
3 growth/size/body region MP:0005378 10.36 PTH REN SOD1 TF VDR ACE
4 hematopoietic system MP:0005397 10.31 ACE B2M CYP27B1 EPO FGF23 INS
5 endocrine/exocrine gland MP:0005379 10.3 ACE ALB B2M CYP27B1 FGF23 INS
6 immune system MP:0005387 10.3 ACE AGT B2M CRP CYP27B1 EPO
7 mortality/aging MP:0010768 10.22 MKS1 PTH REN SOD1 TF VDR
8 integument MP:0010771 10.09 B2M CYP27B1 EPO FGF23 INS LEP
9 digestive/alimentary MP:0005381 10.08 ALB B2M FGF23 INS LEP MKS1
10 liver/biliary system MP:0005370 10.07 B2M EPO HMGCR INS LEP MKS1
11 limbs/digits/tail MP:0005371 9.95 VDR CYP27B1 EPO FGF23 LEP MKS1
12 muscle MP:0005369 9.91 AGT ALB CST3 EPO INS LEP
13 renal/urinary system MP:0005367 9.9 ACE AGT ALB CYP27B1 FGF23 INS
14 reproductive system MP:0005389 9.77 ACE AGT B2M CST3 CYP27B1 FGF23
15 skeleton MP:0005390 9.28 CYP27B1 EPO FGF23 INS LEP MKS1

Drugs & Therapeutics for Chronic Kidney Failure

Drugs for Chronic Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 952)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
3
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
4
Peginterferon alfa-2b Approved Phase 4,Phase 1 99210-65-8, 215647-85-1
5
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
6
Digoxin Approved Phase 4,Phase 2 20830-75-5 30322 2724385
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
8
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
9
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
10
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 159351-69-6 6442177
11
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 22916-47-8 4189
12
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 53123-88-9 5284616 6436030 46835353
13
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 104987-11-3 445643 439492
14
Spironolactone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1952-01-7, 52-01-7 5833
15
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 616-91-1 12035
16
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
17
Ticagrelor Approved Phase 4,Phase 3,Phase 1,Phase 2 274693-27-5 9871419
18
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1 55142-85-3 5472
19
Candesartan Approved Phase 4,Phase 3,Phase 1,Phase 2 139481-59-7 2541
20
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 75847-73-3 5362032 40466924
21
Enalaprilat Approved Phase 4,Phase 3,Phase 2,Phase 1 76420-72-9 6917719
22
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
23
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
24
Icodextrin Approved, Investigational Phase 4,Phase 3,Phase 2 337376-15-5
25
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2 216503-57-0
26
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
27
Daclizumab Approved, Investigational Phase 4,Phase 3,Phase 2 152923-56-3
28
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
29
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
30
Alprostadil Approved, Investigational Phase 4 745-65-3 149351
31
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
32
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
33
Febuxostat Approved Phase 4,Phase 2,Phase 3 144060-53-7 134018
34
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
35
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 54-31-9 3440
36
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Early Phase 1 58-93-5 3639
37
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
38
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
39
Ezetimibe Approved Phase 4 163222-33-1 150311
40
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 128794-94-5 5281078
41
Mycophenolic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 24280-93-1 446541
42
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
43
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137862-53-4 60846
44
Basiliximab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 152923-56-3, 179045-86-4
45
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
46
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
47
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
48
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
49
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
50
Methyltestosterone Approved Phase 4,Phase 3,Phase 1 58-18-4 6010

Interventional clinical trials:

(show top 50) (show all 3279)
id Name Status NCT ID Phase
1 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4
2 Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4
3 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
4 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
5 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4
6 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4
7 Aspirin in the Prevention of Cardiovascular Events in Hemodialysis Patients Unknown status NCT01198379 Phase 4
8 Efficacy Study of Everolimus on Renal Function in Heart Transplant Recipients With Established Chronic Renal Failure Unknown status NCT00716573 Phase 4
9 Mineralocorticoid Receptor Antagonist and Kidney Allograft Histology Unknown status NCT01510795 Phase 4
10 Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction Unknown status NCT01580046 Phase 4
11 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4
12 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4
13 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4
14 Intravenous Iron in Patients With Anemia of Chronic Kidney Disease Unknown status NCT00204256 Phase 4
15 Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
16 Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients Unknown status NCT02459288 Phase 4
17 Value Antiproteinuric Effects From Vitamin D Derivatives in Patient With Chronic Kidney Illness and the Lack of Vitamin D Unknown status NCT01442272 Phase 4
18 Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
19 Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease Unknown status NCT00235287 Phase 4
20 Body Composition Monitor in Hemodialysis Patients Unknown status NCT01103167 Phase 4
21 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4
22 Open-label, Randomized Trial to Determine the Effect of Icodextrin Versus Dextrose (Dianeal 2.5%) in HOMA IR Unknown status NCT01093547 Phase 4
23 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4
24 Egg Albumin-Based Protein Supplement Versus Renal-specific Supplement in Hemodialysis Patients Unknown status NCT01981083 Phase 4
25 Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Unknown status NCT00807144 Phase 4
26 More Frequent Dialysis (>3 Treatments Per Week) Unknown status NCT00575497 Phase 4
27 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4
28 Morbidity and Mortality Among Dialysis Patients After Treatment for Depression Unknown status NCT00442429 Phase 4
29 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4
30 Cardiovascular Protective Effect of Spironolactone in Hemodialysis Unknown status NCT00277693 Phase 4
31 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
32 Hypervolemia in ESRD Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
33 Fibrosis in Renal Allografts Unknown status NCT00493194 Phase 4
34 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4
35 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
36 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4
37 Efficacy and Safety of Alprostadil Prevent Contrast Induced Nephropathy Unknown status NCT01722513 Phase 4
38 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
39 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
40 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4
41 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4
42 The Effect of Uric Acid Lowering in Type 1 Diabetes Unknown status NCT02344602 Phase 4
43 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
44 Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function Unknown status NCT01977430 Phase 4
45 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4
46 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4
47 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4
48 Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy Unknown status NCT00861731 Phase 4
49 Hemocontrol's Effectiveness on the Reduction of Cardiovascular Long-term EventS Unknown status NCT01515878 Phase 4
50 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: kidney failure, chronic

Genetic Tests for Chronic Kidney Failure

Genetic tests related to Chronic Kidney Failure:

id Genetic test Affiliating Genes
1 Chronic Kidney Disease 29

Anatomical Context for Chronic Kidney Failure

MalaCards organs/tissues related to Chronic Kidney Failure:

39
Kidney, Bone, Testes, Bone Marrow, Heart, Neutrophil, Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Potential therapeutic candidate, affected by disease
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Chronic Kidney Failure

Articles related to Chronic Kidney Failure:

(show top 50) (show all 107)
id Title Authors Year
1
Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia. ( 28042744 )
2017
2
Latinos With Chronic Kidney Failure Treated by Dialysis: Understanding Their Palliative Care Perspectives. ( 26612276 )
2016
3
NEW INSIGHTS INTO THE EFFECTS OF CHRONIC KIDNEY FAILURE AND DIALYSATE EXPOSURE ON THE PERITONEUM. ( 27147290 )
2016
4
Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load. ( 26769003 )
2016
5
Assessment of erythropoietin for treatment of anemia in chronic kidney failure- ESRD patients. ( 27470337 )
2016
6
Reappraisal in two European cohorts ofA theA prognostic power of left ventricular massA indexA in chronic kidney failure. ( 28010886 )
2016
7
Checkpoint inhibitors in chronic kidney failure and an organ transplant recipient. ( 27614165 )
2016
8
Brown tumour in phalanx of the ring finger due to chronic kidney failure. A case report. ( 27894859 )
2016
9
Indication for Dialysis Initiation and Mortality in Patients With Chronic Kidney Failure: A Retrospective Cohort Study. ( 27637132 )
2016
10
Icariin protects rats against 5/6 nephrectomy-induced chronic kidney failure by increasing the number of renal stem cells. ( 26490949 )
2015
11
Sudden Visual Deterioration as the First Symptom of Chronic Kidney Failure. ( 26955339 )
2015
12
Lymphangiogenesis and Lymphatic Absorption Are Related and Increased in Chronic Kidney Failure, Independent of Exposure to Dialysis Solutions. ( 26714383 )
2015
13
Neutrophil gelatinase-associated lipocalin as early predictor of acute kidney injury after cardiac surgery in adults with chronic kidney failure. ( 25595830 )
2015
14
Association of dialysis adequacy with nutritional and inflammatory status in patients with chronic kidney failure. ( 26586053 )
2015
15
Peritoneal dialysis in China: meeting the challenge of chronic kidney failure. ( 25446022 )
2015
16
Grover's disease in chronic kidney failure. ( 26299177 )
2015
17
Enhanced Psychosocial Support for Caregiver Burden forA Patients With Chronic Kidney Failure Choosing NotA toA BeA Treated by Dialysis or Transplantation: A Pilot Randomized Controlled Trial. ( 26549852 )
2015
18
Reduced Cardiovascular Reserve in Chronic Kidney Failure: AA Matched Cohort Study. ( 25900597 )
2015
19
Does the Stage of Chronic Kidney Failure Influence the Outcome in Cardiac Surgery? ( 26768636 )
2015
20
Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure. ( 26221597 )
2015
21
Patient engagement and patient-centred care in the management of advanced chronic kidney disease and chronic kidney failure. ( 25780613 )
2014
22
Convective Versus Diffusive Dialysis Therapies for Chronic Kidney Failure: An Updated Systematic Review of Randomized Controlled Trials. ( 24434188 )
2014
23
Understanding discordant meta-analyses of convective dialytic therapies for chronic kidney failure. ( 24856616 )
2014
24
Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. ( 24856028 )
2014
25
Improving integrated care in chronic kidney failure patients with a standard-based interoperability framework. ( 25160260 )
2014
26
Understanding by Older Patients of Dialysis and Conservative Management for Chronic Kidney Failure. ( 25304984 )
2014
27
Familial mixed nephrocalcinosis as a cause of chronic kidney failure: two case reports. ( 25346103 )
2014
28
Effect of hemodiafiltration or hemofiltration compared with hemodialysis on mortality and cardiovascular disease in chronic kidney failure: a systematic review and meta-analysis of randomized trials. ( 24685515 )
2014
29
Association of PTH and carotid thickness in patients with chronic kidney failure and secondary hyperparathyroidism. ( 25317613 )
2014
30
Understanding iron: promoting its safe use in patients with chronic kidney failure treated by hemodialysis. ( 23375852 )
2013
31
Changes in bone matrix mineralization after growth hormone treatment in children and adolescents with chronic kidney failure treated by dialysis: a paired biopsy study. ( 23465957 )
2013
32
Micromolecular multiple myeloma with chronic kidney failure in a young female patient on continuous hemodialysis. ( 23529328 )
2013
33
Convective therapies versus low-flux hemodialysis for chronic kidney failure: a meta-analysis of randomized controlled trials. ( 24081858 )
2013
34
Activities of lipogenic enzymes in subcutaneous adipose tissue are not increased in patients with chronic kidney failure. ( 23160012 )
2013
35
Comment on the question 'Are the aims of the K/DOQI guidelines for mineral metabolism disorders in predialysis chronic kidney failure unachievable or inadequate?'. ( 23712231 )
2013
36
Low estimated glomerular filtration rate and chronic kidney failure following liver transplant: a retrospective cohort study. ( 23897230 )
2013
37
Effectiveness of a nurse-led intensive educational programme on chronic kidney failure patients with hyperphosphataemia: randomised controlled trial. ( 23480506 )
2013
38
Non-albuminuric renal disease among subjects with advanced stages of chronic kidney failure related to type 2 diabetes mellitus. ( 24059817 )
2013
39
Paraoxonase 1 in chronic kidney failure. ( 22523692 )
2012
40
Peginesatide (Omontys) for anemia in chronic kidney failure. ( 22683926 )
2012
41
High-flux and low-flux dialysis membranes and levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in children with chronic kidney failure. ( 22976263 )
2012
42
Ask the doctors. I am 71 years old, have chronic kidney failure, and am on dialysis. I know my overall outlook is not good, and I wonder whether it is worth it to take a statin to control my cholesterol. ( 23476941 )
2012
43
ECG of the month. Electrocardiogram in a man with chronic kidney failure. ECG is abnormal and indicative of heart disease. ( 23362595 )
2012
44
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. ( 22772369 )
2012
45
Successful treatment of peritonitis by C. bertholletiae in a chronic kidney failure patient on continuous ambulatory peritoneal dialysis after kidney rejection. ( 22584986 )
2012
46
Pathology in practice. Chronic kidney failure. ( 21401426 )
2011
47
Etanercept treatment in rheumatoid arthritis patients with chronic kidney failure on predialysis. ( 19705121 )
2010
48
Hemolysis in a patient with alkaptonuria and chronic kidney failure. ( 20207456 )
2010
49
Induction of chronic kidney failure in a long-term peritoneal exposure model in the rat: effects on functional and structural peritoneal alterations. ( 20421431 )
2010
50
Negative effects of chronic kidney failure on lung function and functional capacity. ( 20464163 )
2010

Variations for Chronic Kidney Failure

ClinVar genetic disease variations for Chronic Kidney Failure:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MKS1 NM_017777.3(MKS1): c.1115_1117delCCT (p.Ser372del) deletion Pathogenic rs754279998 GRCh37 Chromosome 17, 56285514: 56285516
2 PKD2 NM_000297.3(PKD2): c.357_364delCCCGGGCAinsTAGGACG (p.Pro120Argfs) indel Pathogenic rs1057518797 GRCh38 Chromosome 4, 88008090: 88008097

Expression for Chronic Kidney Failure

Search GEO for disease gene expression data for Chronic Kidney Failure.

Pathways for Chronic Kidney Failure

GO Terms for Chronic Kidney Failure

Cellular components related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 ACE AGT ALB B2M CRP CST3
2 endoplasmic reticulum lumen GO:0005788 9.63 ALB B2M CST3 FGF23 INS TF
3 extracellular space GO:0005615 9.5 ACE AGT ALB B2M CRP CST3
4 HFE-transferrin receptor complex GO:1990712 9.26 B2M TF

Biological processes related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 AGT CST3 EPO HMGCR INS LEP
2 response to drug GO:0042493 9.98 B2M CST3 PTH REN SOD1
3 aging GO:0007568 9.91 AGT EPO HMGCR SOD1
4 response to ethanol GO:0045471 9.85 HMGCR LEP PTH SOD1
5 response to nutrient GO:0007584 9.82 EPO HMGCR LEP
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.79 AGT INS LEP
7 embryo implantation GO:0007566 9.77 CST3 EPO SOD1
8 positive regulation of DNA replication GO:0045740 9.75 CST3 EPO INS
9 acute-phase response GO:0006953 9.73 CRP EPO INS
10 response to nutrient levels GO:0031667 9.73 CST3 LEP PTH SOD1
11 intestinal absorption GO:0050892 9.67 LEP VDR
12 positive regulation of glycogen biosynthetic process GO:0045725 9.67 INS PTH
13 response to axon injury GO:0048678 9.67 CST3 EPO SOD1
14 heart contraction GO:0060047 9.66 ACE SOD1
15 positive regulation of keratinocyte differentiation GO:0045618 9.66 CYP27B1 VDR
16 beta-amyloid metabolic process GO:0050435 9.65 ACE REN
17 positive regulation of insulin receptor signaling pathway GO:0046628 9.65 INS LEP
18 positive regulation of cytokine production GO:0001819 9.65 AGT LEP SOD1
19 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.64 AGT HMGCR
20 vitamin D metabolic process GO:0042359 9.63 CYP27B1 FGF23
21 cellular response to leptin stimulus GO:0044320 9.63 FGF23 LEP
22 negative regulation of lipid storage GO:0010888 9.62 CRP LEP
23 retina homeostasis GO:0001895 9.62 ALB B2M SOD1 TF
24 cellular response to iron ion GO:0071281 9.61 B2M TF
25 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.6 ACE AGT
26 angiotensin maturation GO:0002003 9.58 ACE AGT REN
27 renin-angiotensin regulation of aldosterone production GO:0002018 9.57 AGT REN
28 regulation of blood pressure GO:0008217 9.55 ACE AGT LEP REN SOD1
29 regulation of blood volume by renin-angiotensin GO:0002016 9.54 AGT REN
30 positive regulation of superoxide anion generation GO:0032930 9.54 AGT CRP SOD1
31 vitamin D catabolic process GO:0042369 9.52 CYP27B1 FGF23
32 regulation of renal output by angiotensin GO:0002019 9.46 ACE AGT
33 negative regulation of vasodilation GO:0045908 9.43 CRP HMGCR INS
34 cellular protein metabolic process GO:0044267 9.17 ALB B2M CST3 FGF23 INS TF
35 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.13 CYP27B1 FGF23 VDR
36 negative regulation of apoptotic process GO:0043066 10.04 ALB EPO HMGCR LEP SOD1

Molecular functions related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 ALB B2M CST3 INS SOD1 TTR
2 hormone activity GO:0005179 9.1 AGT EPO INS LEP PTH TTR
3 peptide hormone receptor binding GO:0051428 8.96 LEP PTH

Sources for Chronic Kidney Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO