Aliases & Classifications for Chronic Kidney Failure

MalaCards integrated aliases for Chronic Kidney Failure:

Name: Chronic Kidney Failure 37 12
Chronic Kidney Disease 12 28 40 3 14
Kidney Failure, Chronic 41 69
Ckd 12 3
Chronic Renal Failure Syndrome 12
Chronic Kidney Disease Stage 5 69
Renal Failure - Chronic 12
Chronic Kidney Diseases 69
Chronic Renal Disease 12
Chronic Renal Failure 72
Renal Failure Chronic 51
Crf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:784
ICD10 32 N18.9 N18
ICD9CM 34 585.6
MeSH 41 D007676
NCIt 46 C9438

Summaries for Chronic Kidney Failure

MedlinePlus : 40 You have two kidneys, each about the size of your fist. Their main job is to filter your blood. They remove wastes and extra water, which become urine. They also keep the body's chemicals balanced, help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged and can't filter blood as they should. This damage can cause wastes to build up in your body. It can also cause other problems that can harm your health. Diabetes and high blood pressure are the most common causes of CKD. The kidney damage occurs slowly over many years. Many people don't have any symptoms until their kidney disease is very advanced. Blood and urine tests are the only way to know if you have kidney disease. Treatments cannot cure kidney disease, but they may slow kidney disease. They include medicines to lower blood pressure, control blood sugar, and lower cholesterol. CKD may still get worse over time. Sometimes it can lead to kidney failure. If your kidneys fail, you will need dialysis or a kidney transplantation. You can take steps to keep your kidneys healthier longer: Choose foods with less salt (sodium) Control your blood pressure; your health care provider can tell you what your blood pressure should be Keep your blood sugar in the target range, if you have diabetes Limit the amount of alcohol you drink Choose foods that are healthy for your heart: fruits, vegetables, whole grains, and low-fat dairy foods Lose weight if you are overweight Be physically active Don't smoke NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Chronic Kidney Failure, also known as chronic kidney disease, is related to end stage renal failure and peritonitis, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Failure is PKD2 (Polycystin 2, Transient Receptor Potential Cation Channel), and among its related pathways/superpathways are HIF-1 signaling pathway and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Capsaicin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney... more...

Related Diseases for Chronic Kidney Failure

Diseases in the Kidney Disease family:

Acute Kidney Failure Chronic Kidney Failure
Renal Infectious Disease

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 end stage renal failure 32.9 ACE AGT ALB CRP CST3 EPO
2 peritonitis 30.6 ALB B2M CRP
3 hyporeninemic hypoaldosteronism 30.6 ACE REN
4 hyperphosphatemia 30.5 FGF23 PTH VDR
5 hypoaldosteronism 30.4 ACE REN
6 pyelonephritis 30.3 ACE ALB CRP
7 renal osteodystrophy 30.3 FGF23 PTH VDR
8 hyperuricemia 30.2 CRP INS REN
9 hyperparathyroidism 30.2 EPO FGF23 PTH VDR
10 secondary hyperparathyroidism of renal origin 30.1 ALB EPO FGF23 PTH VDR
11 interstitial nephritis 30.1 ACE AGT ALB CRP REN
12 diabetes mellitus 29.9 ACE AGT ALB CRP INS LEP
13 heart disease 29.8 ACE ALB CRP CST3 HMGCR INS
14 kidney disease 29.3 ACE ALB B2M CST3 EPO FGF23
15 nephrocalcinosis 11.1
16 dent disease 1 10.8
17 focal segmental glomerulosclerosis 10.8
18 uremic pruritus 10.8
19 paramyloidosis 10.8 ALB TTR
20 marasmus 10.7 ALB TF TTR
21 kwashiorkor 10.7 ALB TF TTR
22 short-rib thoracic dysplasia 9 with or without polydactyly 10.7
23 hypouricemia, renal, 1 10.7
24 hypouricemia, renal, 2 10.7
25 pure red-cell aplasia 10.7 ALB EPO TF
26 median rhomboid glossitis 10.7 B2M TF TTR
27 burns 10.7 ALB INS TTR
28 fetal erythroblastosis 10.7 ALB EPO INS
29 autonomic nervous system disease 10.7 ALB INS TTR
30 retinitis pigmentosa 7 10.7 B2M TF TTR
31 renal artery disease 10.7 ACE EPO REN
32 testicular yolk sac tumor 10.7 ALB TF TTR
33 malignant otitis externa 10.7 CRP INS
34 folic acid deficiency anemia 10.7 CRP EPO TF
35 urinary tract obstruction 10.7 ALB B2M REN
36 renal artery obstruction 10.7 ACE REN
37 decubitus ulcer 10.7 ALB CRP TTR
38 immunodeficiency 43 10.7 ALB B2M
39 benign essential hypertension 10.7 ALB REN
40 uremic neuropathy 10.7 B2M EPO PTH
41 pyelitis 10.7 B2M CRP REN
42 renal tuberculosis 10.7 B2M CRP REN
43 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.7 CRP INS LEP
44 obstructive jaundice 10.7 ALB REN TTR
45 amyloidosis aa 10.7 B2M CRP TTR
46 protein-energy malnutrition 10.7 ALB LEP TF TTR
47 pediatric hypertension 10.7 ACE AGT
48 hemorrhagic fever with renal syndrome 10.7 ALB B2M CRP
49 autonomic neuropathy 10.7 ALB EPO INS
50 orthostatic proteinuria 10.7 ACE ALB B2M REN

Comorbidity relations with Chronic Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 116)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Acute Vascular Insufficiency of Intestine
Alcoholic Liver Cirrhosis Amyloidosis
Aortic Valve Disease 1 Bacteremia 2
Benign Essential Hypertension Benign Hypertensive Renal Disease
Benign Renovascular Hypertension Bladder Cancer
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Myocardial Ischemia Chronic Rapidly Progressive Glomerulonephritis
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Duodenitis Encephalopathy
Esophageal Candidiasis Esophageal Disease
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Goodpasture Syndrome Gout
Heart Disease Hemolytic-Uremic Syndrome
Hepatic Encephalopathy Hepatorenal Syndrome
Hydronephrosis Hyperparathyroidism

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to Chronic Kidney Failure

Symptoms & Phenotypes for Chronic Kidney Failure

UMLS symptoms related to Chronic Kidney Failure:


cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to Chronic Kidney Failure:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.39 VDR PTH REN FGF23 PKD2 B2M
2 homeostasis/metabolism MP:0005376 10.38 TF TTR VDR PTH REN PKD2
3 growth/size/body region MP:0005378 10.3 TF PKD2 VDR PTH REN LEP
4 endocrine/exocrine gland MP:0005379 10.22 PKD2 VDR PTH ALB LEP FGF23
5 hematopoietic system MP:0005397 10.21 TF PKD2 VDR PTH REN LEP
6 mortality/aging MP:0010768 10.19 TF VDR PTH REN LEP FGF23
7 immune system MP:0005387 10.18 PKD2 VDR PTH REN LEP FGF23
8 digestive/alimentary MP:0005381 10.1 PKD2 VDR ALB LEP FGF23 B2M
9 liver/biliary system MP:0005370 10.02 PKD2 LEP B2M ACE HMGCR MKS1
10 muscle MP:0005369 9.76 VDR REN ALB LEP CST3 AGT
11 renal/urinary system MP:0005367 9.73 VDR REN LEP FGF23 PKD2 ACE
12 reproductive system MP:0005389 9.36 VDR REN LEP FGF23 B2M ACE

Drugs & Therapeutics for Chronic Kidney Failure

Drugs for Chronic Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 909)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
3
Peginterferon alfa-2b Approved Phase 4,Phase 1 215647-85-1, 99210-65-8
4
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
5
Nitric Oxide Approved Phase 4,Phase 2,Phase 1,Not Applicable 10102-43-9 145068
6
Digoxin Approved Phase 4 20830-75-5 2724385 30322
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
8
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 616-91-1 12035
9
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1 120202-66-6, 113665-84-2 60606
10
Ticagrelor Approved Phase 4,Phase 3,Phase 1,Phase 2 274693-27-5 9871419
11
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1 55142-85-3 5472
12
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 76631-46-4, 113775-47-6 5311068 56032 68602
13
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
14
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
15
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
16
Spironolactone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1952-01-7, 52-01-7 5833
17
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 216503-57-0
18
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
19
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 104987-11-3 445643 439492
20
Bupivacaine Approved, Investigational Phase 4,Phase 3 38396-39-3, 2180-92-9 2474
21
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
22
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
23
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
24
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 54-31-9 3440
25
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 58-93-5 3639
26
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
27
Pioglitazone Approved, Investigational Phase 4,Phase 2,Not Applicable 111025-46-8 4829
28
Ezetimibe Approved Phase 4 163222-33-1 150311
29
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
30
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
31
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137862-53-4 60846
32 Benidipine Approved, Investigational Phase 4 105979-17-7
33
Fosinopril Approved Phase 4,Phase 3 98048-97-6 55891
34
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 7439-89-6 23925
35
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
36
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 75847-73-3 40466924 5362032
37
Enalaprilat Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 76420-72-9 6917719
38
Pitavastatin Approved Phase 4,Phase 1 147511-69-1, 147526-32-7 5282452 6366718
39
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 46507594 772
40
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable 88150-42-9 2162
41
Allopurinol Approved Phase 4,Phase 3,Not Applicable 315-30-0 2094
42
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 159351-69-6 6442177
43
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
44
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
45
Colchicine Approved Phase 4,Phase 2 64-86-8 2833 6167
46
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 128794-94-5 5281078
47
Mycophenolic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 24280-93-1 446541
48 Taurolidine Approved, Investigational Phase 4,Phase 3 19388-87-5
49
Basiliximab Approved, Investigational Phase 4,Phase 3,Phase 2 179045-86-4, 152923-56-3
50
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865

Interventional clinical trials:

(show top 50) (show all 3331)

# Name Status NCT ID Phase Drugs
1 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
2 Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
3 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
4 Effect of Sodium Rinsing Fluid on Blood Pressure and Interdialytic Weight Change in Hemodialysis Patients Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
5 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
6 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
7 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
8 Aspirin in the Prevention of Cardiovascular Events in Hemodialysis Patients Unknown status NCT01198379 Phase 4 aspirin;Placebo
9 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
10 Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
11 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
12 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
13 Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
14 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Unknown status NCT02661295 Phase 4 Ferric Citrate
15 Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis Unknown status NCT02338635 Phase 4 Ursodeoxycholic Acid
16 Body Composition Monitor in Hemodialysis Patients Unknown status NCT01103167 Phase 4
17 Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
18 Anesthetic Technique for AV Fistulae Creation Unknown status NCT01727557 Phase 4
19 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4 Oxycodone
20 Hypervolemia in ESRD Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
21 Cardiovascular Protective Effect of Spironolactone in Hemodialysis Unknown status NCT00277693 Phase 4 Spironolactone (drug)
22 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
23 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4 N-acetylcysteine
24 Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Unknown status NCT00807144 Phase 4 Tacrolimus (Kidney transplant maintenance immunosuppression);Kidney transplant maintenance immunosuppression
25 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
26 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
27 More Frequent Dialysis (>3 Treatments Per Week) Unknown status NCT00575497 Phase 4
28 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
29 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
30 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
31 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
32 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
33 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
34 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
35 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
36 Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function Unknown status NCT01977430 Phase 4 Hydrochlorothiazide and furosemide
37 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
38 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
39 Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
40 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
41 Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease Unknown status NCT02299310 Phase 4 Valsartan;Perindopril
42 Keto-/Amino Acid Supplemented Low Protein Diet in Patients With Chronic Kidney Disease Unknown status NCT00364884 Phase 4 ketoaminoacid
43 Efficacy and Safety of Simvast Controlled Release (CR) and Zocor in Chronic Kidney Disease(CKD) Stage 3, 4 and 5 Patients With Hyperlipidemia Unknown status NCT01564875 Phase 4 Simvast CR;Zocor
44 Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension Unknown status NCT02646397 Phase 4 Fosinopril;Benidipine;Hydrochlorothiazide
45 Pure Red Cell Aplasia in Patients With Chronic Kidney Disease and in Use of Epoetin Alfa Unknown status NCT02648126 Phase 4
46 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
47 Intravenous Iron in Patients With Anemia of Chronic Kidney Disease Unknown status NCT00204256 Phase 4 Iron sucrose
48 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
49 The Prevention of Contrast Induced Nephropathy by Sarpogrelate in Patients With Chronic Kidney Disease Unknown status NCT01165567 Phase 4 sarpogrelate
50 Renal Effects of Meditarranean Diet and Low-protein Diet With Ketoacids on Physiological Intestinal Mibrobiota in CKD Unknown status NCT02302287 Phase 4

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: kidney failure, chronic

Genetic Tests for Chronic Kidney Failure

Genetic tests related to Chronic Kidney Failure:

# Genetic test Affiliating Genes
1 Chronic Kidney Disease 28

Anatomical Context for Chronic Kidney Failure

MalaCards organs/tissues related to Chronic Kidney Failure:

38
Kidney, Bone, Heart, Endothelial, Testes, Bone Marrow, Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Potential therapeutic candidate, affected by disease
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Chronic Kidney Failure

Articles related to Chronic Kidney Failure:

(show top 50) (show all 1991)
# Title Authors Year
1
Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique? ( 29405657 )
2018
2
Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care. ( 29444881 )
2018
3
Urinary orosomucoid is associated with progressive chronic kidney disease stage in patients with sickle cell anemia. ( 29327376 )
2018
4
Alkaline Phosphatases in the Complex Chronic Kidney Disease-Mineral and Bone Disorders. ( 29445837 )
2018
5
The prevalence and association of chronic kidney disease and diabetes in liver cirrhosis using different estimated glomerular filtration rate equation. ( 29416767 )
2018
6
Hepcidin and proinflammatory markers inA children with chronic kidney disease: AA case-control studya8c. ( 29451472 )
2018
7
Treatment of Hyperuricemia in Chronic Kidney Disease. ( 29393124 )
2018
8
Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease. ( 29447254 )
2018
9
Efficacy and safety of dual antiplatelet therapy after coronary stenting in patients with chronic kidney disease. ( 29447770 )
2018
10
Plasma triglycerides as a risk factor for chronic kidney disease in type 2 diabetes mellitus: Evidence from the northeastern of Thailand. ( 29448006 )
2018
11
EQ-5D-Y for the assessment of health-related quality of life among Taiwanese youth with mild-to-moderate chronic kidney disease. ( 29447362 )
2018
12
Chronic kidney disease mortality trends in selected Central America countries, 1997-2013: clues to an epidemic of chronic interstitial nephritis of agricultural communities. ( 29437864 )
2018
13
A novel UMOD gene mutation associated with chronic kidney failure at a young age. ( 29424336 )
2018
14
Differential Clinical Outcomes Between Angiographic Complete Versus Incomplete Coronary Revascularization, According to the Presence of Chronic Kidney Disease in the Drug-Eluting Stent Era. ( 29449272 )
2018
15
Evaluation of Serum Symmetric Dimethylarginine Concentration as a Marker for Masked Chronic Kidney Disease in Cats With Hyperthyroidism. ( 29377360 )
2018
16
Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells. ( 29393109 )
2018
17
Proton Pump Inhibitors and Chronic Kidney Disease: Is It Related to the Accumulation of Toxic Breakdown Products Spontaneously Formed in the Enteric-Protected Tablets? ( 29452088 )
2018
18
Chronic kidney disease and acquired mitochondrial myopathy. ( 29266014 )
2018
19
Cinacalcet versus Placebo for secondary hyperparathyroidism in chronic kidney disease patients: a meta-analysis of randomized controlled trials and trial sequential analysis. ( 29449603 )
2018
20
Influence of concurrent chronic kidney disease on intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism. ( 29128188 )
2018
21
Cardiac Magnetic Resonance Imaging of the Myocardium in Chronic Kidney Disease. ( 29444516 )
2018
22
Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. ( 28055049 )
2017
23
Serum adiponectin and protein-energy wasting in predialysis chronic kidney disease. ( 27692989 )
2017
24
CE: Improving Outcomes for Patients with Chronic Kidney Disease: Part 1. ( 28085685 )
2017
25
Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease. ( 29032332 )
2017
26
Role of Hepcidin-25 in Chronic Kidney Disease: Anemia and Beyond. ( 28302014 )
2017
27
Mild cognitive impairment in older adults with pre-dialysis patients with chronic kidney disease: Prevalence and association with physical function. ( 28949427 )
2017
28
Correlations of Plasma Desphosphorylated Uncarboxylated Matrix Gla Protein with Vascular Calcification and Vascular Stiffness in Chronic Kidney Disease. ( 27951533 )
2017
29
IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival. ( 28614418 )
2017
30
Development of a novel chronic kidney disease mouse model to evaluate the progression of hyperphosphatemia and associated mineral bone disease. ( 28533541 )
2017
31
Plasma Urotensin II levels in children and adolescents with chronic kidney disease: a single-centre study. ( 28359257 )
2017
32
Management of the Metabolic Acidosis of Chronic Kidney Disease. ( 29031356 )
2017
33
Association of genetic variants of pentraxin 3 rs3816527 with hypertension in Chronic kidney disease patients. ( 27838804 )
2017
34
Restenosis in Hemodialytic Fistulas and Chronic Kidney Disease-Associated Vascular Disease: Two Pathologies Driven by Metakaryotic Stem Cells. ( 28535522 )
2017
35
Metabolic acidosis is common and associates with disease progression in children with chronic kidney disease. ( 28729033 )
2017
36
Trends in healthcare expenditure in United States adults with chronic kidney disease: 2002-2011. ( 28532412 )
2017
37
The prevalence, subtypes and associated factors of hyperuricemia in lupus nephritis patients at chronic kidney disease stages 1-3. ( 28915657 )
2017
38
Chronic kidney disease in the BCR-ABL1-negative myeloproliferative neoplasm: a single-center retrospective study. ( 28298076 )
2017
39
CD36 in chronic kidney disease: novel insights and therapeutic opportunities. ( 28919632 )
2017
40
Mechanism Underlying Linezolid-induced Thrombocytopenia in a Chronic Kidney Failure Mouse Model. ( 28405130 )
2017
41
Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease. ( 28087576 )
2017
42
MMP-2 and 9 in Chronic Kidney Disease. ( 28397744 )
2017
43
Drug disposition model of radiolabeled etelcalcetide in patients with chronic kidney disease and secondary hyperparathyroidism on hemodialysis. ( 28063122 )
2017
44
Leptospirosis Renal Disease: Emerging Culprit of Chronic Kidney Disease Unknown Etiology. ( 28926845 )
2017
45
The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. ( 28951066 )
2017
46
Sodium and fluid management in the conservative management of Chronic Kidney Disease. ( 28090763 )
2017
47
The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury. ( 29241624 )
2017
48
Association of H. pylori infection with chronic kidney disease among Chinese adults. ( 28044235 )
2017
49
Urine Ammonium, Metabolic Acidosis and Progression of Chronic Kidney Disease. ( 29050011 )
2017
50
A tripartite complex of suPAR, APOL1 risk variants and I+vI^3 integrin on podocytes mediates chronic kidney disease. ( 28650456 )
2017

Variations for Chronic Kidney Failure

ClinVar genetic disease variations for Chronic Kidney Failure:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MKS1 NM_017777.3(MKS1): c.1115_1117delCCT (p.Ser372del) deletion Pathogenic rs754279998 GRCh37 Chromosome 17, 56285514: 56285516
2 PKD2 NM_000297.3(PKD2): c.357_364delCCCGGGCAinsTAGGACG (p.Pro120Argfs) indel Pathogenic rs1057518797 GRCh38 Chromosome 4, 88008090: 88008097

Expression for Chronic Kidney Failure

Search GEO for disease gene expression data for Chronic Kidney Failure.

Pathways for Chronic Kidney Failure

GO Terms for Chronic Kidney Failure

Cellular components related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ACE AGT ALB B2M CRP CST3
2 endoplasmic reticulum lumen GO:0005788 9.63 ALB B2M CST3 FGF23 INS TF
3 extracellular space GO:0005615 9.47 ACE AGT ALB B2M CRP CST3
4 HFE-transferrin receptor complex GO:1990712 9.26 B2M TF
5 extracellular exosome GO:0070062 10.02 ACE AGT ALB B2M CRP CST3

Biological processes related to Chronic Kidney Failure according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.95 AGT CST3 EPO HMGCR INS LEP
2 response to estradiol GO:0032355 9.82 AGT CST3 LEP
3 cellular calcium ion homeostasis GO:0006874 9.81 PKD2 PTH VDR
4 response to nutrient GO:0007584 9.78 EPO HMGCR LEP
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 AGT INS LEP
6 response to nutrient levels GO:0031667