MCID: CHR057
MIFTS: 30

Chronic Laryngitis

Categories: Respiratory diseases, Infectious diseases

Aliases & Classifications for Chronic Laryngitis

MalaCards integrated aliases for Chronic Laryngitis:

Name: Chronic Laryngitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11797
ICD10 33 J37.0
ICD9CM 35 476.0
NCIt 47 C26975
UMLS 69 C0155836

Summaries for Chronic Laryngitis

Disease Ontology : 12 A laryngitis in which symptoms last longer than three weeks. Gastroesophageal reflux, and lingering bronchitis can cause the disease.

MalaCards based summary : Chronic Laryngitis is related to rhabdomyosarcoma and scrotum melanoma. An important gene associated with Chronic Laryngitis is ATP4A (ATPase H+/K+ Transporting Alpha Subunit), and among its related pathways/superpathways are Salivary secretion and Secretion of Hydrochloric Acid in Parietal Cells. The drugs Esomeprazole and Antacids have been mentioned in the context of this disorder. Affiliated tissues include trachea.

Related Diseases for Chronic Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Chronic Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 10.8 ATP4A HRH2
2 scrotum melanoma 10.7 ATP12A ATP4A
3 congenital aphakia 10.7 ATP12A ATP4A
4 brain ependymoma 10.7 ATP4A HRH2
5 shwartzman phenomenon 10.7 ATP12A ATP4A
6 primary syphilis 10.7 ATP12A ATP4A
7 bone giant cell sarcoma 10.7 ATP12A ATP4A
8 urethral calculus 10.7 ATP12A ATP4A
9 breast ductal adenoma 10.7 ATP12A ATP4A
10 scrotum squamous cell carcinoma 10.7 ATP4A CYP2C19
11 hypopituitarism 10.7 ATP12A ATP4A
12 amyotrophic lateral sclerosis type 5 10.7 ATP12A ATP4A
13 scrotal carcinoma 10.7 ATP4A HRH2
14 abnormal pupillary function 10.7 ATP12A ATP4A
15 atheroembolism of kidney 10.7 ATP12A ATP4A
16 microphthalmia, syndromic 12 10.7 ATP12A ATP4A
17 synostosis 10.7 ATP12A ATP4A
18 muscle cancer 10.7 ATP12A ATP4A
19 polysyndactyly with cardiac malformation 10.6 ATP12A ATP4A
20 paracoccidioidomycosis 10.6 ATP4A CYP2C19
21 focal hand dystonia 10.6 ATP12A ATP4A
22 cloacal exstrophy 10.6 ATP12A ATP4A
23 proliferative fasciitis 10.6 ATP12A ATP4A
24 hodgkin's paragranuloma 10.6 ATP12A ATP4A
25 spinocerebellar ataxia 18 10.6 ATP12A ATP4A
26 lacrimal apparatus disease 10.5 ATP4A CYP2C19 HRH2
27 fungal gastritis 10.5 ATP12A ATP4A
28 extrahepatic bile duct papillary adenoma 10.5 ATP4A CYP2C19 HRH2
29 cubitus valgus with mental retardation and unusual facies 10.5 ATP12A ATP4A
30 adult xanthogranuloma 10.5 ATP12A ATP4A HRH2
31 scleral staphyloma 10.5 ATP12A ATP4A HRH2
32 pediatric infratentorial ependymoblastoma 10.5 ATP12A ATP4A HRH2
33 fibrosarcomatous osteosarcoma 10.5 ATP12A ATP4A HRH2
34 villous adenocarcinoma 10.5 ATP12A ATP4A
35 ileocolitis 10.5 ATP12A ATP4A
36 allergic urticaria 10.4 ATP12A ATP4A
37 mesenteric vascular occlusion 10.4 ATP12A ATP4A
38 anterior cerebral artery infarction 10.3 ATP12A ATP4A
39 gnathomiasis 10.3 ATP12A ATP4A
40 laryngitis 10.3
41 frontal sinus schneiderian papilloma 10.2 ATP12A ATP4A CYP2C19 HRH2
42 intracranial sinus thrombosis 10.2 ATP12A ATP4A KRT19
43 hepatic veno-occlusive disease 10.2 ATP12A ATP4A
44 thrombocytopenia due to platelet alloimmunization 10.2 ATP12A ATP4A CDK9 LYZ
45 prostatic cyst 10.0 ATP12A ATP4A
46 laryngotracheitis 10.0
47 gastroesophageal reflux 9.8
48 urethra clear cell adenocarcinoma 9.7 GP5 KRT19
49 pharyngitis 9.7
50 esophagitis 9.5

Comorbidity relations with Chronic Laryngitis via Phenotypic Disease Network (PDN):


Bronchitis

Graphical network of the top 20 diseases related to Chronic Laryngitis:



Diseases related to Chronic Laryngitis

Symptoms & Phenotypes for Chronic Laryngitis

Drugs & Therapeutics for Chronic Laryngitis

Drugs for Chronic Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
2 Antacids Phase 4
3 Anti-Ulcer Agents Phase 4
4 Gastrointestinal Agents Phase 4
5
Proton pump inhibitors Phase 4
6
Amitriptyline Approved Phase 2, Phase 3 50-48-6 2160
7
Perphenazine Approved Phase 2, Phase 3 58-39-9 4748
8 Adrenergic Agents Phase 2, Phase 3
9 Amitriptyline, perphenazine drug combination Phase 2, Phase 3
10 Analgesics Phase 2, Phase 3
11 Analgesics, Non-Narcotic Phase 2, Phase 3
12 Antidepressive Agents Phase 2, Phase 3
13 Antidepressive Agents, Tricyclic Phase 2, Phase 3
14 Antipsychotic Agents Phase 2, Phase 3
15 Central Nervous System Depressants Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3
19 Psychotropic Drugs Phase 2, Phase 3
20 Tranquilizing Agents Phase 2, Phase 3
21
Omeprazole Approved, Investigational, Vet_approved 73590-58-6 4594
22 Mitogens

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux Completed NCT00628667 Phase 4 Esomeprazole;Placebo
2 Treatment of Chronic Laryngitis With Amitriptyline Recruiting NCT02552225 Phase 2, Phase 3 Amitriptyline
3 Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
4 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220
5 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis Completed NCT01389401 omeprazole

Search NIH Clinical Center for Chronic Laryngitis

Genetic Tests for Chronic Laryngitis

Anatomical Context for Chronic Laryngitis

MalaCards organs/tissues related to Chronic Laryngitis:

39
Trachea

Publications for Chronic Laryngitis

Articles related to Chronic Laryngitis:

(show top 50) (show all 51)
id Title Authors Year
1
Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. ( 27749540 )
2016
2
Metabolic Syndrome and Chronic Laryngitis: The Korean National Health and Nutrition Examination Survey 2008 to 2010. ( 26512606 )
2015
3
The role of biofilm in chronic laryngitis and in head and neck cancer. ( 26371604 )
2015
4
Association between Chronic Laryngitis and Particulate Matter Based on the Korea National Health and Nutrition Examination Survey 2008-2012. ( 26177353 )
2015
5
Association between Obesity and Chronic Laryngitis in Women--Data from the Korea National Health and Nutrition Examination Survey. ( 26138994 )
2015
6
Detection of Chronic Laryngitis due to Laryngopharyngeal Reflux Using Color and Texture Analysis of Laryngoscopic Images. ( 24314831 )
2014
7
Acute laryngitis superimposed on chronic laryngitis. ( 23460211 )
2013
8
Incidence of chronic laryngitis. ( 24592580 )
2013
9
An oropharyngeal pH monitoring device to evaluate patients with chronic laryngitis. ( 23495894 )
2013
10
Predictors of acid suppression success in patients with chronic laryngitis. ( 22276941 )
2012
11
Comparison of patients of chronic laryngitis with and without troublesome reflux symptoms. ( 21793907 )
2012
12
Bacterial biofilm associated with chronic laryngitis. ( 22652944 )
2012
13
Effect of pantoprazole in patients with chronic laryngitis and pharyngitis related to gastroesophageal reflux disease: clinical, proximal, and distal pH monitoring results. ( 20002704 )
2010
14
Benefit of acid-suppressive therapy in chronic laryngitis: the devil is in the details. ( 20621625 )
2010
15
GERD-related chronic laryngitis: pro. ( 20855685 )
2010
16
Gastroesophageal reflux-related chronic laryngitis. Commentary. ( 20855686 )
2010
17
Gastroesophageal reflux-related chronic laryngitis: con. ( 20855684 )
2010
18
Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. ( 20735783 )
2010
19
Salivary egf concentration in adults with reflux chronic laryngitis before and after treatment: preliminary results. ( 17589721 )
2007
20
Gastro-oesophageal reflux disease in chronic laryngitis: prevalence and response to acid-suppressive therapy. ( 17269990 )
2007
21
Chronic laryngitis associated with gastroesophageal reflux: prospective assessment of differences in practice patterns between gastroenterologists and ENT physicians. ( 16542282 )
2006
22
Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. ( 17037995 )
2006
23
Chronic laryngitis in glassblowers. ( 15895845 )
2005
24
Severe chronic laryngitis mimicking a granulomatous disease. ( 15628624 )
2004
25
Improvement in clinical course and laryngeal appearance in selected patients with chronic laryngitis after eight weeks of therapy with rabeprazole. ( 15448612 )
2004
26
Interaction of sleep disturbances and gastroesophageal reflux in chronic laryngitis. ( 11791245 )
2002
27
Absence of bacterial infection in the mucosal secretion in chronic laryngitis. ( 11081617 )
2000
28
Role of esophageal pH recording in management of chronic laryngitis: an overview. ( 11051423 )
2000
29
Diagnosis and management of chronic laryngitis associated with reflux. ( 10718463 )
2000
30
A possible role of helicobacter pylori infection in the etiology of chronic laryngitis. ( 23119449 )
1998
31
Langerhans and other immunocompetent cells in vocal cord epithelial hyperplastic lesions of patients with chronic laryngitis. ( 9197489 )
1997
32
A possible role of Helicobacter pylori infection in the etiology of chronic laryngitis. ( 9438124 )
1997
33
[Serum dihydrotestosterone versus total testosterone values of patients with laryngeal carcinomas and chronic laryngitis]. ( 8766382 )
1996
34
Outcomes of antireflux therapy for the treatment of chronic laryngitis. ( 7598368 )
1995
35
Herpes simplex chronic laryngitis and vocal cord lesions in a patient with acquired immunodeficiency syndrome. ( 8085735 )
1994
36
Chronic laryngitis. ( 1031346 )
1976
37
The aetiology of chronic laryngitis. ( 1031354 )
1976
38
Vitamin A and chronic laryngitis. ( 4109003 )
1972
39
CHRONIC LARYNGITIS. ( 14302922 )
1965
40
The importance of chronic laryngitis. ( 13825824 )
1960
41
Contribution to treatment of chronic laryngitis in persons who use their voices professionally. ( 21024466 )
1945
42
Prominence of the Cartilages of Santorini and Wrisberg accompanied by Chronic Laryngitis. ( 19988473 )
1931
43
Slide showing Section of a Gland removed from a man with Chronic Laryngitis and an Enlarged Gland in the Neck. ( 19983734 )
1924
44
Case of Chronic Laryngitis of Long Standing. ( 19982948 )
1923
45
Chronic Laryngitis in an Unusual Form. ( 19977894 )
1914
46
Chronic Laryngitis. ( 19975088 )
1911
47
Chronic Laryngitis in a Man aged 26.? Prolapse of Ventricle on Right Side. ( 19974415 )
1910
48
Two Lectures on Chronic Laryngitis and Chronic Pharyngitis: Their Pathology, Symptoms, and Treatment. ( 20751315 )
1885
49
Two Lectures on Chronic Laryngitis and Chronic Pharyngitis: Their Pathology, Symptoms, and Treatment. ( 20751317 )
1885
50
Case of Aneurism of the Thoracic Aorta: Bursting into the Trachea, Simulating Chronic Laryngitis. ( 20795146 )
1852

Variations for Chronic Laryngitis

Expression for Chronic Laryngitis

Search GEO for disease gene expression data for Chronic Laryngitis.

Pathways for Chronic Laryngitis

Pathways related to Chronic Laryngitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 ATP4A HRH2 LYZ
2 9.32 ATP4A HRH2

GO Terms for Chronic Laryngitis

Biological processes related to Chronic Laryngitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Chronic Laryngitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Chronic Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....