MCID: CHR057
MIFTS: 34

Chronic Laryngitis

Categories: Respiratory diseases, Infectious diseases

Aliases & Classifications for Chronic Laryngitis

MalaCards integrated aliases for Chronic Laryngitis:

Name: Chronic Laryngitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11797
ICD10 32 J37.0
ICD9CM 34 476.0
NCIt 46 C26975
UMLS 69 C0155836

Summaries for Chronic Laryngitis

Disease Ontology : 12 A laryngitis in which symptoms last longer than three weeks. Gastroesophageal reflux, and lingering bronchitis can cause the disease.

MalaCards based summary : Chronic Laryngitis is related to laryngitis and acute laryngitis. An important gene associated with Chronic Laryngitis is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Salivary secretion and Secretion of Hydrochloric Acid in Parietal Cells. The drugs Amitriptyline and Perphenazine have been mentioned in the context of this disorder. Affiliated tissues include trachea, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chronic Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Chronic Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 laryngitis 31.2 ATP12A ATP4A HRH2
2 acute laryngitis 30.1 ATP12A ATP4A
3 fungal esophagitis 10.6 ATP12A ATP4A
4 bladder calculus 10.6 ATP12A ATP4A
5 gastrointestinal neuroendocrine benign tumor 10.6 ATP12A ATP4A
6 gastric neuroendocrine neoplasm 10.6 ATP12A ATP4A
7 neonatal candidiasis 10.6 ATP12A ATP4A
8 photoallergic dermatitis 10.6 ATP12A ATP4A
9 squamous papillomatosis 10.6 ATP12A ATP4A
10 gastroduodenal crohn's disease 10.6 ATP12A ATP4A
11 toxic megacolon 10.6 ATP12A ATP4A
12 gastric antral vascular ectasia 10.6 ATP12A ATP4A
13 postsurgical hypothyroidism 10.6 ATP12A ATP4A
14 rumination disorder 10.6 ATP12A ATP4A
15 duodenitis 10.6 ATP12A ATP4A
16 congenital disorder of deglycosylation 10.5 ATP12A ATP4A
17 bile reflux 10.5 ATP12A ATP4A
18 granulomatous gastritis 10.5 ATP12A ATP4A
19 dyskinesia of esophagus 10.5 ATP12A ATP4A
20 ischemic neuropathy 10.5 ATP12A ATP4A
21 anismus 10.5 ATP12A ATP4A
22 capillary disease 10.5 ATP12A ATP4A
23 duodenal disease 10.5 ATP12A ATP4A
24 esophageal atresia/tracheoesophageal fistula 10.5 ATP12A ATP4A
25 lymphocytic colitis 10.5 ATP12A ATP4A
26 chronic intestinal vascular insufficiency 10.5 ATP12A ATP4A
27 clostridium difficile colitis 10.5 ATP12A ATP4A
28 lower urinary tract calculus 10.5 ATP12A ATP4A
29 diarrhea 1, secretory chloride, congenital 10.5 ATP12A ATP4A
30 aspiration pneumonia 10.5 ATP12A ATP4A
31 esophageal varix 10.5 ATP12A ATP4A
32 eosinophilic gastritis 10.4 ATP12A ATP4A
33 aspiration pneumonitis 10.4 ATP12A ATP4A HRH2
34 active peptic ulcer disease 10.4 ATP12A ATP4A HRH2
35 functional gastric disease 10.4 ATP12A ATP4A HRH2
36 peptic ulcer perforation 10.4 ATP12A ATP4A HRH2
37 esophageal candidiasis 10.4 ATP12A ATP4A CYP2C19
38 stomach disease 10.4 ATP12A ATP4A HRH2
39 myopathy, x-linked, with excessive autophagy 10.4 ATP12A ATP4A
40 hernia, hiatus 10.4 ATP12A ATP4A CYP2C19
41 esophagus adenocarcinoma 10.4 ATP12A ATP4A
42 peptic ulcer disease 10.4 ATP4A CYP2C19 HRH2
43 laryngeal disease 10.4 ATP12A ATP4A LVRN
44 jejunoileitis 10.4 ATP12A ATP4A
45 pancreatic steatorrhea 10.3 ATP12A ATP4A
46 pneumatosis cystoides intestinalis 10.3 ATP12A ATP4A
47 lateral medullary syndrome 10.3 ATP12A ATP4A
48 peptic esophagitis 10.3 ATP12A ATP4A CYP2C19 HRH2
49 esophageal disease 10.2 ATP12A ATP4A CYP2C19 HRH2
50 laryngeal tuberculosis 10.2 ATP12A ATP4A CDK9 LYZ

Comorbidity relations with Chronic Laryngitis via Phenotypic Disease Network (PDN):


Bronchitis

Graphical network of the top 20 diseases related to Chronic Laryngitis:



Diseases related to Chronic Laryngitis

Symptoms & Phenotypes for Chronic Laryngitis

GenomeRNAi Phenotypes related to Chronic Laryngitis according to GeneCards Suite gene sharing:

25 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.72 GMPS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.72 CDK9
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.72 GMPS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.72 GMPS KRT19
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.72 GMPS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.72 GMPS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.72 GMPS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.72 GMPS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.72 CDK9
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.72 CDK9 GMPS KRT19 SLC4A1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.72 GMPS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.72 GMPS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.72 GMPS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.72 GMPS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.72 GMPS
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.72 KRT19 SLC4A1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.72 KRT19
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.72 GMPS
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.72 CDK9
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.72 GMPS

Drugs & Therapeutics for Chronic Laryngitis

Drugs for Chronic Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amitriptyline Approved Phase 2, Phase 3 50-48-6 2160
2
Perphenazine Approved Phase 2, Phase 3 58-39-9 4748
3 Adrenergic Agents Phase 2, Phase 3
4 Amitriptyline, perphenazine drug combination Phase 2, Phase 3
5 Analgesics Phase 2, Phase 3
6 Analgesics, Non-Narcotic Phase 2, Phase 3
7 Antidepressive Agents Phase 2, Phase 3
8 Antidepressive Agents, Tricyclic Phase 2, Phase 3
9 Antipsychotic Agents Phase 2, Phase 3
10 Central Nervous System Depressants Phase 2, Phase 3
11 Neurotransmitter Agents Phase 2, Phase 3
12 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
13 Peripheral Nervous System Agents Phase 2, Phase 3
14 Psychotropic Drugs Phase 2, Phase 3
15 Tranquilizing Agents Phase 2, Phase 3
16
Omeprazole Approved, Investigational, Vet_approved 73590-58-6 4594
17 Mitogens
18 Antacids
19 Anti-Ulcer Agents
20 Gastrointestinal Agents
21 Proton pump inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Chronic Laryngitis With Amitriptyline Suspended NCT02552225 Phase 2, Phase 3 Amitriptyline
2 Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
3 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220
4 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis Completed NCT01389401 omeprazole

Search NIH Clinical Center for Chronic Laryngitis

Genetic Tests for Chronic Laryngitis

Anatomical Context for Chronic Laryngitis

MalaCards organs/tissues related to Chronic Laryngitis:

38
Trachea

Publications for Chronic Laryngitis

Articles related to Chronic Laryngitis:

(show top 50) (show all 52)
# Title Authors Year
1
Korean survey data reveals an association of chronic laryngitis with tinnitus in men. ( 29324903 )
2018
2
Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. ( 27749540 )
2016
3
Association between Obesity and Chronic Laryngitis in Women--Data from the Korea National Health and Nutrition Examination Survey. ( 26138994 )
2015
4
Metabolic Syndrome and Chronic Laryngitis: The Korean National Health and Nutrition Examination Survey 2008 to 2010. ( 26512606 )
2015
5
Association between Chronic Laryngitis and Particulate Matter Based on the Korea National Health and Nutrition Examination Survey 2008-2012. ( 26177353 )
2015
6
The role of biofilm in chronic laryngitis and in head and neck cancer. ( 26371604 )
2015
7
Detection of Chronic Laryngitis due to Laryngopharyngeal Reflux Using Color and Texture Analysis of Laryngoscopic Images. ( 24314831 )
2014
8
An oropharyngeal pH monitoring device to evaluate patients with chronic laryngitis. ( 23495894 )
2013
9
Incidence of chronic laryngitis. ( 24592580 )
2013
10
Acute laryngitis superimposed on chronic laryngitis. ( 23460211 )
2013
11
Predictors of acid suppression success in patients with chronic laryngitis. ( 22276941 )
2012
12
Comparison of patients of chronic laryngitis with and without troublesome reflux symptoms. ( 21793907 )
2012
13
Bacterial biofilm associated with chronic laryngitis. ( 22652944 )
2012
14
GERD-related chronic laryngitis: pro. ( 20855685 )
2010
15
Gastroesophageal reflux-related chronic laryngitis. Commentary. ( 20855686 )
2010
16
Effect of pantoprazole in patients with chronic laryngitis and pharyngitis related to gastroesophageal reflux disease: clinical, proximal, and distal pH monitoring results. ( 20002704 )
2010
17
Gastroesophageal reflux-related chronic laryngitis: con. ( 20855684 )
2010
18
Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. ( 20735783 )
2010
19
Benefit of acid-suppressive therapy in chronic laryngitis: the devil is in the details. ( 20621625 )
2010
20
Salivary egf concentration in adults with reflux chronic laryngitis before and after treatment: preliminary results. ( 17589721 )
2007
21
Gastro-oesophageal reflux disease in chronic laryngitis: prevalence and response to acid-suppressive therapy. ( 17269990 )
2007
22
Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. ( 17037995 )
2006
23
Chronic laryngitis associated with gastroesophageal reflux: prospective assessment of differences in practice patterns between gastroenterologists and ENT physicians. ( 16542282 )
2006
24
Chronic laryngitis in glassblowers. ( 15895845 )
2005
25
Improvement in clinical course and laryngeal appearance in selected patients with chronic laryngitis after eight weeks of therapy with rabeprazole. ( 15448612 )
2004
26
Severe chronic laryngitis mimicking a granulomatous disease. ( 15628624 )
2004
27
Interaction of sleep disturbances and gastroesophageal reflux in chronic laryngitis. ( 11791245 )
2002
28
Absence of bacterial infection in the mucosal secretion in chronic laryngitis. ( 11081617 )
2000
29
Diagnosis and management of chronic laryngitis associated with reflux. ( 10718463 )
2000
30
Role of esophageal pH recording in management of chronic laryngitis: an overview. ( 11051423 )
2000
31
A possible role of helicobacter pylori infection in the etiology of chronic laryngitis. ( 23119449 )
1998
32
A possible role of Helicobacter pylori infection in the etiology of chronic laryngitis. ( 9438124 )
1997
33
Langerhans and other immunocompetent cells in vocal cord epithelial hyperplastic lesions of patients with chronic laryngitis. ( 9197489 )
1997
34
[Serum dihydrotestosterone versus total testosterone values of patients with laryngeal carcinomas and chronic laryngitis]. ( 8766382 )
1996
35
Outcomes of antireflux therapy for the treatment of chronic laryngitis. ( 7598368 )
1995
36
Herpes simplex chronic laryngitis and vocal cord lesions in a patient with acquired immunodeficiency syndrome. ( 8085735 )
1994
37
The aetiology of chronic laryngitis. ( 1031354 )
1976
38
Chronic laryngitis. ( 1031346 )
1976
39
Vitamin A and chronic laryngitis. ( 4109003 )
1972
40
CHRONIC LARYNGITIS. ( 14302922 )
1965
41
The importance of chronic laryngitis. ( 13825824 )
1960
42
Contribution to treatment of chronic laryngitis in persons who use their voices professionally. ( 21024466 )
1945
43
Prominence of the Cartilages of Santorini and Wrisberg accompanied by Chronic Laryngitis. ( 19988473 )
1931
44
Slide showing Section of a Gland removed from a man with Chronic Laryngitis and an Enlarged Gland in the Neck. ( 19983734 )
1924
45
Case of Chronic Laryngitis of Long Standing. ( 19982948 )
1923
46
Chronic Laryngitis in an Unusual Form. ( 19977894 )
1914
47
Chronic Laryngitis. ( 19975088 )
1911
48
Chronic Laryngitis in a Man aged 26.? Prolapse of Ventricle on Right Side. ( 19974415 )
1910
49
Two Lectures on Chronic Laryngitis and Chronic Pharyngitis: Their Pathology, Symptoms, and Treatment. ( 20751315 )
1885
50
Two Lectures on Chronic Laryngitis and Chronic Pharyngitis: Their Pathology, Symptoms, and Treatment. ( 20751317 )
1885

Variations for Chronic Laryngitis

Expression for Chronic Laryngitis

Search GEO for disease gene expression data for Chronic Laryngitis.

Pathways for Chronic Laryngitis

Pathways related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 ATP4A HRH2 LYZ
2 9.32 ATP4A HRH2

GO Terms for Chronic Laryngitis

Cellular components related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 8.8 KRT19 PDLIM1 SLC4A1

Biological processes related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Chronic Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....