MCID: CHR418
MIFTS: 37

Chronic Leukemia malady

Cancer diseases category
Download this MalaCard

Summaries for Chronic Leukemia

About this section


Fully expand this MalaCard
Wikipedia:65 Chronic leukemia is an increase of abnormal white blood cells. It differs from acute leukemia, and is... more...

MalaCards based summary: Chronic Leukemia, also known as chronic leukaemia, is related to leukemia and chronic lymphocytic leukemia. An important gene associated with Chronic Leukemia is WT1 (Wilms tumor 1), and among its related pathways is ABC-family proteins mediated transport. The compounds gemtuzumab ozogamicin and estradiol-17beta-glucuronide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Disease Ontology:8 A leukemia that develops slowly.

Aliases & Classifications for Chronic Leukemia

About this section
Sources:
8Disease Ontology, 44Novoseek, 62UMLS
See all sources

Chronic Leukemia, Aliases & Descriptions:

Name: Chronic Leukemia 8 44
 
Chronic Leukaemia 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:1036

Related Diseases for Chronic Leukemia

About this section

Diseases in the Leukemia family:

Acute Leukemia chronic leukemia
Subacute Leukemia

Diseases related to Chronic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.4WT1, BCR, ABCC1, ABCB4
2chronic lymphocytic leukemia29.9ABCB4, BCR
3myeloid leukemia29.8WT1, ABCC1, BCR
4wilms tumor29.7ABCC1, WT1
5chronic myeloid leukemia29.5ABCC1, WT1, BCR
6myelodysplastic syndromes10.2
7rhabdoid tumor10.1WT1, BCR
8peripheral primitive neuroectodermal tumor10.1BCR, WT1
9acute myeloid leukemia10.1
10chronic myelomonocytic leukemia10.1
11leukemia, t-cell, chronic10.1
12thrombocythemia 110.1
13acute myeloid leukemia, adult10.0WT1, ABCC1
14intrahepatic cholestasis10.0ABCB4, ABCC1
15cholestasis10.0ABCB4, ABCC1
16rhabdomyosarcoma9.9ABCC1, WT1
17acute lymphoblastic leukemia, childhood9.9ABCC1, BCR
18juvenile myelomonocytic leukemia9.9
19multiple myeloma9.9
20myelofibrosis9.9
21shwachman-diamond syndrome9.9
22wiskott-aldrich syndrome9.9
23richter's syndrome9.9
24hcl-v9.9
25erythromelalgia9.9
26juvenile xanthogranuloma9.9
27neurofibromatosis9.9
28aggressive systemic mastocytosis9.9
29parotitis9.9
30herpes zoster9.9
31subacute leukemia9.9
32diffuse cutaneous mastocytosis9.9
33childhood leukemia9.9
34disseminated intravascular coagulation9.9
35myeloma9.9
36prostatitis9.9
37macroglobulinemia, waldenstrom, somatic9.9
38emberger syndrome9.9
39leopard syndrome 19.9
40endotheliitis9.9
41systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease9.9
42liver cirrhosis9.9ABCB4, ABCC1
43acute erythroid leukemia9.8ABCB4, ABCC1
44precursor t-cell acute lymphoblastic leukemia9.8BCR, ABCC1, WT1
45hematologic cancer9.8BCR, ABCC1, WT1
46acute lymphoblastic leukemia9.8ABCC1, BCR, WT1
47retinoblastoma9.7BCR, WT1, ABCC1
48liver cancer9.7ABCC1, BCR, ABCB4
49acute leukemia9.6BCR, ABCB4, ABCC1, WT1

Graphical network of the top 20 diseases related to Chronic Leukemia:



Diseases related to chronic leukemia

Symptoms for Chronic Leukemia

About this section

Drugs & Therapeutics for Chronic Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Chronic Leukemia

Search NIH Clinical Center for Chronic Leukemia

Genetic Tests for Chronic Leukemia

About this section

Anatomical Context for Chronic Leukemia

About this section

MalaCards organs/tissues related to Chronic Leukemia:

32
Myeloid, Bone marrow, Bone, Prostate, Endothelial

Animal Models for Chronic Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Chronic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9WT1, BCR, ABCB4
2MP:00053977.8ABCC1, GFI1B, BCR, WT1
3MP:00053877.5ABCB4, ABCC1, GFI1B, BCR, WT1
4MP:00053767.4WT1, ABCC1, ABCB4, GFI1B, BCR

Publications for Chronic Leukemia

About this section

Articles related to Chronic Leukemia:

(show all 39)
idTitleAuthorsYear
1
Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells. (25058688)
2014
2
Pleural effusions in acute and chronic leukemia and myelodysplastic syndrome. (24811835)
2014
3
Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy. (23936692)
2013
4
Chronic leukemia. (24267282)
2013
5
Exaggerated insect bite reaction related to chronic leukemia. (23541024)
2013
6
Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation. (22547610)
2012
7
Incidental diagnosis of a retroperitoneal schwannoma in a patient with chronic leukemia undergoing prostatic biopsy. (22760935)
2012
8
Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: the MMVAR/IFM 2005-04 Randomized Phase III Trial from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. (22585692)
2012
9
Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/I^-catenin function. (22708678)
2012
10
Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan. (21392127)
2011
11
Regulation of wild type PTEN gene on Survivin, Xiap and Smac in chronic leukemia cells]. (22333553)
2011
12
Understanding and Targeting the Wnt/I^-Catenin Signaling Pathway in Chronic Leukemia. (23213540)
2011
13
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia. (21678379)
2011
14
Specific function of STAT5 in regulation of proliferation of chronic leukemia K562 cells: inhibitory effect of WHI-P131]. (20352702)
2010
15
Inhibition of cell growth by Stellera chamaejasme extract is associated with induction of autophagy and differentiation in chronic leukemia K562 cells. (20547324)
2010
16
Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients. (20376582)
2010
17
Detection, analysis and clinical validation of chromosomal aberrations by multiplex ligation-dependent probe amplification in chronic leukemia. (21049055)
2010
18
Outcome of patients developing GVHD after DLI given to treat CML relapse: a study by the Chronic Leukemia Working Party of the EBMT. (19633691)
2010
19
Treatment of myeloproliferative neoplasms other than chronic leukemia]. (19860198)
2009
20
Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia. (19360458)
2009
21
Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. (19812383)
2009
22
How I treat acute and chronic leukemia in pregnancy. (18472198)
2008
23
Assessment of circulating proteasome chymotrypsin-like activity in plasma of patients with acute and chronic leukemias. (18773885)
2008
24
A retrospective comparison of autologous and unrelated donor hematopoietic cell transplantation in myelodysplastic syndrome and secondary acute myeloid leukemia: a report on behalf of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). (17611571)
2007
25
Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance]. (17956662)
2007
26
PRAME mRNA levels in cases with chronic leukemia: Clinical importance and review of the literature. (16914202)
2007
27
Comparison of mRNA abundance quantified by gene expression profiling and percentage of positive cells using immunophenotyping for diagnostic antigens in acute and chronic leukemias. (17041886)
2006
28
Clinical implications of angiogenic factors in patients with acute or chronic leukemia: hepatocyte growth factor levels have prognostic impact, especially in patients with acute myeloid leukemia. (16019534)
2005
29
Expression and cellular localization of vascular endothelial growth factor A and its receptors in acute and chronic leukemias: an immunohistochemical study. (16084950)
2005
30
TNR/11q#1 trinucleotide (GCC)n repeat alleles and predisposition to acute and chronic leukemia. (15225161)
2004
31
Proliferation and apoptosis in acute and chronic leukemias and myelodysplastic syndrome. (12007503)
2002
32
Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture. (10676644)
2000
33
Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. (10979972)
2000
34
Expression of the MDR1 and MDR3 gene products in acute and chronic leukemias. (9150348)
1997
35
MDR1, MRP, topoisomerase IIalpha/beta, and cyclin A gene expression in acute and chronic leukemias. (8656699)
1996
36
Interferon DNA polymorphism in chronic leukemia. (7912973)
1994
37
Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. (7911548)
1994
38
Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. (1972761)
1990
39
Herpes zoster with a varicelliform eruption and parotitis in chronic leukemia. (14794487)
1951

Variations for Chronic Leukemia

About this section

Expression for genes affiliated with Chronic Leukemia

About this section
Expression patterns in normal tissues for genes affiliated with Chronic Leukemia

Search GEO for disease gene expression data for Chronic Leukemia.

Pathways for genes affiliated with Chronic Leukemia

About this section

Pathways related to Chronic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ABCB4, ABCC1

Compounds for genes affiliated with Chronic Leukemia

About this section

Compounds related to Chronic Leukemia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1gemtuzumab ozogamicin50 44 1111.5WT1, ABCC1
2estradiol-17beta-glucuronide449.5ABCB4, ABCC1
3glycocholate449.5ABCB4, ABCC1
4rhodamine 12344 5010.4ABCC1, ABCB4
5taurocholate449.4ABCB4, ABCC1
6daunorubicin44 50 1111.4ABCB4, ABCC1
7homoharringtonine44 50 1111.3ABCC1, BCR
8colchicine44 61 2 28 1113.3ABCC1, ABCB4
9verapamil44 28 50 24 1113.2ABCB4, ABCC1
10adriamycin449.2ABCB4, ABCC1
11cytarabine44 50 1111.2BCR, ABCC1
12methotrexate50 44 1111.1ABCB4, ABCC1
13curcumin449.1ABCC1, WT1
14oligonucleotide449.1ABCB4, WT1, BCR
15vincristine44 50 1111.0ABCB4, ABCC1, WT1
16etoposide44 50 61 1112.0ABCC1, ABCB4, WT1
17doxorubicin44 50 1110.9WT1, ABCC1, ABCB4
18cyclosporin a44 28 6110.9WT1, ABCB4, ABCC1
19imatinib44 50 1110.9WT1, ABCC1, BCR
20arsenite44 249.9WT1, ABCC1
21atp44 289.5ABCB4, ABCC1, BCR

GO Terms for genes affiliated with Chronic Leukemia

About this section

Molecular functions related to Chronic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATPase activity, coupled to transmembrane movement of substancesGO:0426269.1ABCB4, ABCC1

Products for genes affiliated with Chronic Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Chronic Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet