MCID: CHR418
MIFTS: 30

Chronic Leukemia malady

Cancer diseases category

Summaries for Chronic Leukemia

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Wikipedia:63 Chronic leukemia is an increase of abnormal white blood cells. It differs from acute leukemia, and is... more...

MalaCards based summary: Chronic Leukemia is related to leukemia and chronic lymphocytic leukemia. An important gene associated with Chronic Leukemia is WT1 (Wilms tumor 1), and among its related pathways is ABC-family proteins mediated transport. The compounds gemtuzumab ozogamicin and estradiol-17beta-glucuronide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Disease Ontology:9 A leukemia that develops slowly.

Aliases & Classifications for Chronic Leukemia

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS
See all sources

Chronic Leukemia, Aliases & Descriptions:

Name: Chronic Leukemia 9 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:1036

Related Diseases for Chronic Leukemia

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Diseases in the Leukemia family:

Acute Leukemia chronic leukemia
Subacute Leukemia

Diseases related to Chronic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.4WT1, BCR, ABCC1, ABCB4
2chronic lymphocytic leukemia29.9ABCB4, BCR
3myeloid leukemia29.8WT1, ABCC1, BCR
4wilms tumor29.7ABCC1, WT1
5myelodysplastic syndrome10.2
6rhabdoid tumor10.1WT1, BCR
7chronic myelomonocytic leukemia10.1
8ewing sarcoma10.1BCR, WT1
9acute myeloid leukemia, adult10.0WT1, ABCC1
10intrahepatic cholestasis10.0ABCB4, ABCC1
11cholestasis10.0ABCB4, ABCC1
12rhabdomyosarcoma9.9ABCC1, WT1
13acute lymphoblastic leukemia, childhood9.9ABCC1, BCR
14wiskott-aldrich syndrome9.9
15shwachman-bodian-diamond syndrome9.9
16multiple myeloma9.9
17myelofibrosis9.9
18systemic mastocytosis9.9
19waldenstrom macroglobulinemia9.9
20richter's syndrome9.9
21hemorrhagic thrombocythemia9.9
22erythromelalgia9.9
23hcl-v9.9
24parotitis9.9
25herpes zoster9.9
26subacute leukemia9.9
27juvenile xanthogranuloma9.9
28aggressive systemic mastocytosis9.9
29diffuse cutaneous mastocytosis9.9
30leopard syndrome9.9
31childhood leukemia9.9
32disseminated intravascular coagulation9.9
33myeloma9.9
34prostatitis9.9
35essential thrombocythemia9.9
36leukemia, t-cell, chronic9.9
37endotheliitis9.9
38deafness - lymphedema - leukemia9.9
39liver cirrhosis9.9ABCB4, ABCC1
40acute erythroid leukemia9.8ABCB4, ABCC1
41precursor t-cell acute lymphoblastic leukemia9.8BCR, ABCC1, WT1
42hematologic cancer9.8BCR, ABCC1, WT1
43leukemia, chronic myeloid9.8ABCC1, WT1, BCR
44leukemia, acute lymphoblastic9.8ABCC1, BCR, WT1
45retinoblastoma9.7BCR, WT1, ABCC1
46hepatocellular carcinoma9.7ABCC1, BCR, ABCB4
47acute leukemia9.6BCR, ABCB4, ABCC1, WT1

Graphical network of the top 20 diseases related to Chronic Leukemia:



Diseases related to chronic leukemia

Symptoms for Chronic Leukemia

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Drugs & Therapeutics for Chronic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Chronic Leukemia

Search NIH Clinical Center for Chronic Leukemia

Genetic Tests for Chronic Leukemia

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Anatomical Context for Chronic Leukemia

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MalaCards organs/tissues related to Chronic Leukemia:

31
Myeloid, Bone marrow, Bone, Prostate, Endothelial

Animal Models for Chronic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Chronic Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9WT1, BCR, ABCB4
2MP:00053977.8ABCC1, GFI1B, BCR, WT1
3MP:00053877.5ABCB4, ABCC1, GFI1B, BCR, WT1
4MP:00053767.4WT1, ABCC1, ABCB4, GFI1B, BCR

Publications for Chronic Leukemia

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Articles related to Chronic Leukemia:

(show all 39)
idTitleAuthorsYear
1
Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells. (25058688)
2014
2
Pleural effusions in acute and chronic leukemia and myelodysplastic syndrome. (24811835)
2014
3
Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy. (23936692)
2013
4
Chronic leukemia. (24267282)
2013
5
Exaggerated insect bite reaction related to chronic leukemia. (23541024)
2013
6
Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation. (22547610)
2012
7
Incidental diagnosis of a retroperitoneal schwannoma in a patient with chronic leukemia undergoing prostatic biopsy. (22760935)
2012
8
Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: the MMVAR/IFM 2005-04 Randomized Phase III Trial from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. (22585692)
2012
9
Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/I^-catenin function. (22708678)
2012
10
Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan. (21392127)
2011
11
Regulation of wild type PTEN gene on Survivin, Xiap and Smac in chronic leukemia cells]. (22333553)
2011
12
Understanding and Targeting the Wnt/I^-Catenin Signaling Pathway in Chronic Leukemia. (23213540)
2011
13
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia. (21678379)
2011
14
Specific function of STAT5 in regulation of proliferation of chronic leukemia K562 cells: inhibitory effect of WHI-P131]. (20352702)
2010
15
Inhibition of cell growth by Stellera chamaejasme extract is associated with induction of autophagy and differentiation in chronic leukemia K562 cells. (20547324)
2010
16
Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients. (20376582)
2010
17
Detection, analysis and clinical validation of chromosomal aberrations by multiplex ligation-dependent probe amplification in chronic leukemia. (21049055)
2010
18
Outcome of patients developing GVHD after DLI given to treat CML relapse: a study by the Chronic Leukemia Working Party of the EBMT. (19633691)
2010
19
Treatment of myeloproliferative neoplasms other than chronic leukemia]. (19860198)
2009
20
Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia. (19360458)
2009
21
Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. (19812383)
2009
22
How I treat acute and chronic leukemia in pregnancy. (18472198)
2008
23
Assessment of circulating proteasome chymotrypsin-like activity in plasma of patients with acute and chronic leukemias. (18773885)
2008
24
A retrospective comparison of autologous and unrelated donor hematopoietic cell transplantation in myelodysplastic syndrome and secondary acute myeloid leukemia: a report on behalf of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). (17611571)
2007
25
Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance]. (17956662)
2007
26
PRAME mRNA levels in cases with chronic leukemia: Clinical importance and review of the literature. (16914202)
2007
27
Comparison of mRNA abundance quantified by gene expression profiling and percentage of positive cells using immunophenotyping for diagnostic antigens in acute and chronic leukemias. (17041886)
2006
28
Clinical implications of angiogenic factors in patients with acute or chronic leukemia: hepatocyte growth factor levels have prognostic impact, especially in patients with acute myeloid leukemia. (16019534)
2005
29
Expression and cellular localization of vascular endothelial growth factor A and its receptors in acute and chronic leukemias: an immunohistochemical study. (16084950)
2005
30
TNR/11q#1 trinucleotide (GCC)n repeat alleles and predisposition to acute and chronic leukemia. (15225161)
2004
31
Proliferation and apoptosis in acute and chronic leukemias and myelodysplastic syndrome. (12007503)
2002
32
Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture. (10676644)
2000
33
Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. (10979972)
2000
34
Expression of the MDR1 and MDR3 gene products in acute and chronic leukemias. (9150348)
1997
35
MDR1, MRP, topoisomerase IIalpha/beta, and cyclin A gene expression in acute and chronic leukemias. (8656699)
1996
36
Interferon DNA polymorphism in chronic leukemia. (7912973)
1994
37
Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. (7911548)
1994
38
Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. (1972761)
1990
39
Herpes zoster with a varicelliform eruption and parotitis in chronic leukemia. (14794487)
1951

Variations for Chronic Leukemia

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Expression for genes affiliated with Chronic Leukemia

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Search GEO for disease gene expression data for Chronic Leukemia.

Pathways for genes affiliated with Chronic Leukemia

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Pathways related to Chronic Leukemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ABCB4, ABCC1

Compounds for genes affiliated with Chronic Leukemia

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Compounds related to Chronic Leukemia according to GeneCards Suite gene sharing:

(show all 21)
idCompoundScoreTop Affiliating Genes
1gemtuzumab ozogamicin49 43 1211.5WT1, ABCC1
2estradiol-17beta-glucuronide439.5ABCB4, ABCC1
3glycocholate439.5ABCB4, ABCC1
4rhodamine 12343 4910.4ABCC1, ABCB4
5taurocholate439.4ABCB4, ABCC1
6daunorubicin43 49 1211.4ABCB4, ABCC1
7homoharringtonine43 49 1211.3ABCC1, BCR
8colchicine43 59 2 28 1213.3ABCC1, ABCB4
9verapamil43 28 49 24 1213.2ABCB4, ABCC1
10adriamycin439.2ABCB4, ABCC1
11cytarabine43 49 1211.2BCR, ABCC1
12methotrexate49 43 1211.1ABCB4, ABCC1
13curcumin439.1ABCC1, WT1
14oligonucleotide439.1ABCB4, WT1, BCR
15vincristine43 49 1211.0ABCB4, ABCC1, WT1
16etoposide43 49 59 1212.0ABCC1, ABCB4, WT1
17doxorubicin43 49 1210.9WT1, ABCC1, ABCB4
18cyclosporin a43 28 5910.9WT1, ABCB4, ABCC1
19imatinib43 49 1210.9WT1, ABCC1, BCR
20arsenite43 249.9WT1, ABCC1
21atp43 289.5ABCB4, ABCC1, BCR

GO Terms for genes affiliated with Chronic Leukemia

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Molecular functions related to Chronic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATPase activity, coupled to transmembrane movement of substancesGO:00426269.1ABCB4, ABCC1

Products for genes affiliated with Chronic Leukemia

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Chronic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet