CLL
MCID: CHR418
MIFTS: 47

Chronic Leukemia (CLL) malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Chronic Leukemia

Aliases & Descriptions for Chronic Leukemia:

Name: Chronic Leukemia 12 52 14 69
Adult Chronic Leukemia 12
Cll 12
Cml 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1036

Summaries for Chronic Leukemia

Disease Ontology : 12 A leukemia that develops slowly.

MalaCards based summary : Chronic Leukemia, also known as adult chronic leukemia, is related to leukemia and chronic lymphocytic leukemia. An important gene associated with Chronic Leukemia is WT1 (Wilms Tumor 1), and among its related pathways/superpathways are Focal Adhesion and Development HGF signaling pathway. The drugs Arzerra and Campath have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and monocytes, and related phenotypes are Decreased sensitivity to paclitaxel and cellular

Wikipedia : 71 Chronic leukemia is an increase of abnormal white blood cells. It differs from acute leukemia, and is... more...

Related Diseases for Chronic Leukemia

Diseases in the Leukemia family:

Acute Leukemia Chronic Leukemia
Subacute Leukemia

Diseases related to Chronic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 leukemia 11.1
2 chronic lymphocytic leukemia 11.0
3 chronic myelomonocytic leukemia 11.0
4 leukemia, chronic myeloid, somatic 10.9
5 leukemia, t-cell, chronic 10.8
6 childhood leukemia 10.7
7 subacute leukemia 10.7
8 breast ductal carcinoma 10.1 PTEN WT1
9 cellular phase chronic idiopathic myelofibrosis 10.0 STAT3 STAT5B
10 small intestinal sarcoma 10.0 PTEN WT1
11 hemorrhagic fever 10.0 PTEN WT1
12 peroxisome biogenesis disorder 7a 9.9 BCR STAT5B WT1
13 focal epilepsy 9.9 BCR STAT3 STAT5B
14 hemophagocytic lymphohistiocytosis 9.9 BCR STAT5B WT1
15 urethral verrucous carcinoma 9.9 HGF PTEN PTGS2
16 basilar artery insufficiency 9.9 BCR STAT3 STAT5B
17 lower lip cancer 9.8 PTEN PTGS2 STAT3
18 proctitis 9.8 PTEN PTGS2 STAT3
19 cranioectodermal dysplasia 1 9.8 BCR STAT3 STAT5B WT1
20 hypogonadotropic hypogonadism 20 with or without anosmia 9.7 PTEN PTGS2 STAT3
21 myelodysplastic syndrome 9.7
22 cardiomyopathy, dilated, 1h 9.6 ABCB4 HGF PTEN PTGS2 STAT3
23 multiple myeloma 9.5
24 myeloid leukemia 9.5
25 lymphoma 9.5
26 disseminated intravascular coagulation 9.5
27 chronic venous leg ulcers 9.4 ABCB4 ARL11 BCR STAT3
28 pneumonia 9.4
29 glucocorticoid resistance 9.4
30 herpes zoster 9.4
31 endotheliitis 9.4
32 myelofibrosis 9.4
33 parotitis 9.4
34 prostatitis 9.4
35 lymphadenitis 9.4
36 richter's syndrome 9.4
37 myeloproliferative neoplasm 9.4
38 human herpesvirus 8 9.4
39 epididymis adenocarcinoma 8.5 ABCB4 ARL11 BCR GFI1B HGF PTEN

Comorbidity relations with Chronic Leukemia via Phenotypic Disease Network (PDN):


Acute Cystitis Leukemia, B-Cell, Chronic

Graphical network of the top 20 diseases related to Chronic Leukemia:



Diseases related to Chronic Leukemia

Symptoms & Phenotypes for Chronic Leukemia

GenomeRNAi Phenotypes related to Chronic Leukemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 PTEN WT1

MGI Mouse Phenotypes related to Chronic Leukemia:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ABCB4 BCR GFI1B HGF PTEN PTGS2
2 hematopoietic system MP:0005397 10.16 ABCB4 BCR GFI1B HGF PTEN PTGS2
3 cardiovascular system MP:0005385 10.14 ABCB4 GFI1B HGF PTEN PTGS2 SOAT1
4 homeostasis/metabolism MP:0005376 10.09 ABCB4 BCR GFI1B PTEN PTGS2 SOAT1
5 growth/size/body region MP:0005378 10.08 ABCB4 BCR HGF PTEN PTGS2 STAT3
6 immune system MP:0005387 10.06 STAT5B WT1 ABCB4 BCR GFI1B PTEN
7 endocrine/exocrine gland MP:0005379 10.04 ABCB4 PTEN PTGS2 SOAT1 STAT3 STAT5B
8 embryo MP:0005380 9.99 GFI1B HGF PTEN PTGS2 STAT3 WT1
9 liver/biliary system MP:0005370 9.97 ABCB4 BCR HGF PTEN PTGS2 SOAT1
10 integument MP:0010771 9.85 STAT3 STAT5B GFI1B PTEN PTGS2 SOAT1
11 neoplasm MP:0002006 9.73 ABCB4 PTEN PTGS2 SOAT1 STAT3 WT1
12 normal MP:0002873 9.63 BCR PTEN PTGS2 STAT3 STAT5B WT1
13 renal/urinary system MP:0005367 9.43 STAT5B BCR PTEN PTGS2 STAT3 WT1
14 reproductive system MP:0005389 9.1 ABCB4 PTEN PTGS2 STAT3 STAT5B WT1

Drugs & Therapeutics for Chronic Leukemia

FDA approved drugs:

(show all 7)
id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Arzerra 17 46 OFATUMUMAB GlaxoSmithKline Approved October 2009
2
Campath 17 46 ALEMTUZUMAB Berlex Laboratories Approved May 2001
3
Imbruvica 17 46 IBRUTINIB Pharmacyclics Approved November of 2013/Approved February 2014
4
Revlimid 17 46 LENALIDOMIDE Celgene Approved June 2013
5
Rituxan 17 46 RITUXIMAB Biogen IDEC, Genentech Approved November 1997
6
Treanda 17 46 BENDAMUSTINE HYDROCHLORIDE Cephalon Approved October 2008
7
Zydelig 17 46 IDELALISIB Gilead Approved July 2014

Drugs for Chronic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 636)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
2
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
3
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 104987-11-3 445643 439492
4
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
5
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
6
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
7
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
8
Dasatinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 302962-49-8 3062316
9
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
10
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53910-25-1 40926 439693
11
Vidarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 24356-66-9 32326 21704
12
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 55-98-1 2478
13
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
14
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
16
Diphenhydramine Approved Phase 4,Phase 2,Phase 1 58-73-1, 147-24-0 3100
17
alemtuzumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216503-57-0
18
Acitretin Approved Phase 4 55079-83-9 6437841 5284513
19
Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
20
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
21
Promethazine Approved Phase 4,Phase 2,Phase 1 60-87-7 4927
22
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
23
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
25
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
26
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
27
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
28
Pancrelipase Approved Phase 4,Phase 2,Phase 1 53608-75-6
29
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 54575, 6560146 143
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
31 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
32 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
33 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
34 Imatinib Mesylate Phase 4,Phase 3,Phase 2,Phase 1 123596
35 Epoetin alfa Phase 4,Phase 3,Phase 2 113427-24-0
36 interferons Phase 4,Phase 3,Phase 2,Phase 1
37 Alkylating Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
38 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Hematinics Phase 4,Phase 3,Phase 2
43 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2,Phase 1
47
Treosulfan Phase 4,Phase 3,Phase 2 299-75-2 9296
48 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
50 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 2634)
id Name Status NCT ID Phase
1 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4
2 Compliance: Role Emerges for Success in Chronic Myelogenous Leukaemia (CML): Evaluation aND Optimisation Unknown status NCT01243489 Phase 4
3 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
4 Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects? Unknown status NCT01228409 Phase 4
5 Analysis of Data Collected in the European Group for Blood and Marrow Transplantation (EBMT) Registry for Off-Label Transplant Use of Plerixafor Completed NCT01362985 Phase 4
6 Study to Evaluate Nilotinib in Chronic Myelogenous Leukemia (CML) Patients With SubOptimal Response Completed NCT01043874 Phase 4
7 Observational Study in Participants With Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM) and Non-Hodgkin's Lymphoma (NHL) in Latin America Completed NCT02559583 Phase 4
8 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4
9 Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec®-Interferon Alpha in the Treatment of Chronic-Phase Chronic Myeloid Leukaemia Completed NCT00390897 Phase 4
10 An Exploratory Trial to Assess the Improvement of Adverse Events in Chronic Myelogenous Leukemia Patients Treated With Imatinib When Switched to Nilotinib Treatment Completed NCT00980018 Phase 4
11 Study of Oral AMN107 (Nilotinib) in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Previously Enrolled to CAMN107A2109 Trial Completed NCT01368523 Phase 4
12 Study of Molecular Response in Adult Patients on Nilotinib With Philadelphia Chromosome Positive Chronic Myelogenous Leukemia (Ph+ CML) in Chronic Phase and a Suboptimal Molecular Response to Imatinib Completed NCT00644878 Phase 4
13 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4
14 A Study of Rituximab in Combination With Fludarabine and Cyclophosphamide in Participants With Chronic Lymphocytic Leukemia and Favorable Somatic Status Completed NCT01271010 Phase 4
15 Phase IV, Open-label, Multicenter Study of Dasatinib in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients With Chronic, Low-grade Non-Hematologic Toxicity to Imatinib Completed NCT01660906 Phase 4
16 A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status Completed NCT01283386 Phase 4
17 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4
18 Study Comparing Standard Dose and High-dose Imatinib Mesylate in Patients With Chronic Phase Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia (CML) Completed NCT00171899 Phase 4
19 Study of Treatment With Nilotinib in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Completed NCT00786812 Phase 4
20 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4
21 Gleevec Trial in Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia Completed NCT00081926 Phase 4
22 CMR Rate of Newly Diagnosed CML-CP Patients Treated With Nilotinib Completed NCT01227577 Phase 4
23 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4
24 Glivec in Pediatric Chronic Myeloid Leukemia (CML) Completed NCT00845221 Phase 4
25 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
26 Effect of Epoetin Alfa on Hemoglobin, Symptom Distress, and Quality of Life in Patients Receiving Chemotherapy Completed NCT00524407 Phase 4
27 Tasigna in Glivec-resistant or Intolerant Patients in CML Completed NCT01206088 Phase 4
28 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4
29 Safety And Efficacy Study Of Bosutinib In Patients With Philadelphia Chromosome Positive Chronic Myeloid Leukemia Previously Treated With One Or More Tyrosine Kinase Inhibitors Recruiting NCT02228382 Phase 4
30 Therapy of Early Chronic Phase Chronic Myelogenous Leukemia (CML) With Dasatinib Recruiting NCT02689440 Phase 4
31 Study Assessing Deep Molecular Response in Adult Patients With CML in Chronic Phase Treated With Nilotinib Firstline. Recruiting NCT02546674 Phase 4
32 Anti-thymocyte Globulins for Graft-versus-host Disease Prophylaxis Recruiting NCT01856803 Phase 4
33 Low Grade Lymphoma Recruiting NCT01698866 Phase 4
34 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
35 Steroid Treatment for Hypereosinophilic Syndrome Recruiting NCT01524536 Phase 4
36 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4
37 A Study to Evaluate Efficacy and Safety of Glinib in Newly Diagnosed CML Patients Active, not recruiting NCT02204722 Phase 4
38 Validation of Digital-PCR Analysis Through Programmed Imatinib Interruption in PCR Negative CML Patients Active, not recruiting NCT01578213 Phase 4
39 Study of Alemtuzumab Versus Anti-thymocyte Globulin to Help Prevent Rejection in Kidney and Pancreas Transplantation Active, not recruiting NCT00331162 Phase 4
40 Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT) Not yet recruiting NCT01339988 Phase 4
41 Efficacy and Safety of Imatinib Mesylate as First-line Treatment for the Patients With Chronic Phase of Chronic Myeloid Leukemia Not yet recruiting NCT02317159 Phase 4
42 Sustained Treatment-free Remission in BCR-ABL+ Chronic Myeloid Leukemia Not yet recruiting NCT02602314 Phase 4
43 Multicenter, PhaseⅣ, Open Label Trial of Nilotinib in Adult Patients Diagnosed Philadelphia Chromosome Positive(Ph+) Chronic Myeloid Leukemia in CP/AP Intolerant to Dasatinib Not yet recruiting NCT02389920 Phase 4
44 Study of Nilotinib in Ph+ CML-CP Patients With Low Imatinib Trough Plasma Concentrations Terminated NCT01131325 Phase 4
45 Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on Imatinib Terminated NCT00461929 Phase 4
46 Efficacy and Safety Assessment of NIlotinib in CML Patients With Suboptimal Response on Imatinib Therapy Terminated NCT02086487 Phase 4
47 A Study to Assess the Hematopoyetic Response of Anemic Patients With Hematologic Malignancies Treated With Erythropoietin B Terminated NCT02608060 Phase 4
48 A Study of Safety and Effectiveness of Bendamustine Hydrochloride in Adult Filipino Patients With Chronic Lymphocytic Leukemia Withdrawn NCT01739491 Phase 4
49 Trial Evaluating Nilotinib as Treatment for Newly Diagnosed CML Patients in Accelerated Phase. Withdrawn NCT01605981 Phase 4
50 Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation Unknown status NCT01800643 Phase 2, Phase 3

Search NIH Clinical Center for Chronic Leukemia

Genetic Tests for Chronic Leukemia

Anatomical Context for Chronic Leukemia

MalaCards organs/tissues related to Chronic Leukemia:

39
B Cells, T Cells, Monocytes, Nk Cells, Lymph Node, Myeloid, Endothelial

Publications for Chronic Leukemia

Articles related to Chronic Leukemia:

(show all 49)
id Title Authors Year
1
Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells. ( 27579615 )
2016
2
Correlation of Cadmium and Magnesium in the Blood and Serum Samples of Smokers and Non-Smokers Chronic Leukemia Patients. ( 27511371 )
2016
3
Advances in the diagnosis and treatment of acute and chronic leukemia in Mexico. ( 27557388 )
2016
4
Your patient has chronic leukemia: Now what? ( 27505878 )
2016
5
Pregnancy and Accelerated Phase of Myeloid Chronic Leukemia Treated with Imatinib: A Case Report from a Developing Country. ( 27123350 )
2016
6
Outcomes of unrelated cord blood transplantation in patients with multiple myeloma: a survey on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobiology Working Party, and the Chronic Leukemia Working Party of the EBMT. ( 27229716 )
2016
7
Organizing pneumonia appearing in B-cell chronic leukemia malignancy progression - a case report. ( 25985790 )
2015
8
Nodal monoclonal CD5-positive B-lymphocytosis and toxoplasma lymphadenitis: another variant in the spectrum of infectious lymphadenitis in patients with chronic leukemia/small lymphocytic lymphoma. ( 26295844 )
2015
9
Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines. ( 26613081 )
2015
10
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia. ( 26107113 )
2015
11
Pleural effusions in acute and chronic leukemia and myelodysplastic syndrome. ( 24811835 )
2014
12
Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells. ( 25058688 )
2014
13
Exaggerated insect bite reaction related to chronic leukemia. ( 23541024 )
2013
14
Chronic leukemia. ( 24267282 )
2013
15
Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy. ( 23936692 )
2013
16
Incidental diagnosis of a retroperitoneal schwannoma in a patient with chronic leukemia undergoing prostatic biopsy. ( 22760935 )
2012
17
Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation. ( 22547610 )
2012
18
Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/I^-catenin function. ( 22708678 )
2012
19
Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: the MMVAR/IFM 2005-04 Randomized Phase III Trial from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. ( 22585692 )
2012
20
Understanding and Targeting the Wnt/I^-Catenin Signaling Pathway in Chronic Leukemia. ( 23213540 )
2011
21
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia. ( 21678379 )
2011
22
Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan. ( 21392127 )
2011
23
[Regulation of wild type PTEN gene on Survivin, Xiap and Smac in chronic leukemia cells]. ( 22333553 )
2011
24
[Specific function of STAT5 in regulation of proliferation of chronic leukemia K562 cells: inhibitory effect of WHI-P131]. ( 20352702 )
2010
25
Inhibition of cell growth by Stellera chamaejasme extract is associated with induction of autophagy and differentiation in chronic leukemia K562 cells. ( 20547324 )
2010
26
Outcome of patients developing GVHD after DLI given to treat CML relapse: a study by the Chronic Leukemia Working Party of the EBMT. ( 19633691 )
2010
27
Detection, analysis and clinical validation of chromosomal aberrations by multiplex ligation-dependent probe amplification in chronic leukemia. ( 21049055 )
2010
28
Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients. ( 20376582 )
2010
29
Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. ( 19812383 )
2009
30
[Treatment of myeloproliferative neoplasms other than chronic leukemia]. ( 19860198 )
2009
31
Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia. ( 19360458 )
2009
32
How I treat acute and chronic leukemia in pregnancy. ( 18472198 )
2008
33
Assessment of circulating proteasome chymotrypsin-like activity in plasma of patients with acute and chronic leukemias. ( 18773885 )
2008
34
PRAME mRNA levels in cases with chronic leukemia: Clinical importance and review of the literature. ( 16914202 )
2007
35
[Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance]. ( 17956662 )
2007
36
A retrospective comparison of autologous and unrelated donor hematopoietic cell transplantation in myelodysplastic syndrome and secondary acute myeloid leukemia: a report on behalf of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). ( 17611571 )
2007
37
Comparison of mRNA abundance quantified by gene expression profiling and percentage of positive cells using immunophenotyping for diagnostic antigens in acute and chronic leukemias. ( 17041886 )
2006
38
Expression and cellular localization of vascular endothelial growth factor A and its receptors in acute and chronic leukemias: an immunohistochemical study. ( 16084950 )
2005
39
Clinical implications of angiogenic factors in patients with acute or chronic leukemia: hepatocyte growth factor levels have prognostic impact, especially in patients with acute myeloid leukemia. ( 16019534 )
2005
40
TNR/11q#1 trinucleotide (GCC)n repeat alleles and predisposition to acute and chronic leukemia. ( 15225161 )
2004
41
Proliferation and apoptosis in acute and chronic leukemias and myelodysplastic syndrome. ( 12007503 )
2002
42
Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. ( 10979972 )
2000
43
Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture. ( 10676644 )
2000
44
Expression of the MDR1 and MDR3 gene products in acute and chronic leukemias. ( 9150348 )
1997
45
MDR1, MRP, topoisomerase IIalpha/beta, and cyclin A gene expression in acute and chronic leukemias. ( 8656699 )
1996
46
Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. ( 7911548 )
1994
47
Interferon DNA polymorphism in chronic leukemia. ( 7912973 )
1994
48
Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. ( 1972761 )
1990
49
Herpes zoster with a varicelliform eruption and parotitis in chronic leukemia. ( 14794487 )
1951

Variations for Chronic Leukemia

Expression for Chronic Leukemia

Search GEO for disease gene expression data for Chronic Leukemia.

Pathways for Chronic Leukemia

Pathways related to Chronic Leukemia according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 HGF PTEN PTGS2 STAT3
2
Show member pathways
12.52 HGF PTEN PTGS2 STAT3
3
Show member pathways
12.16 PTEN STAT3 STAT5B
4 12.12 GFI1B PTGS2 STAT3 STAT5B
5
Show member pathways
12.1 PTEN STAT3 STAT5B
6 11.9 PTEN STAT3 STAT5B
7
Show member pathways
11.88 PTEN STAT3 STAT5B
8
Show member pathways
11.85 BCR STAT3 STAT5B
9
Show member pathways
11.76 BCR STAT3 STAT5B
10 11.71 HGF STAT3 WT1
11 11.7 BCR HGF PTEN PTGS2 STAT3 STAT5B
12 11.6 HGF PTGS2 STAT3
13
Show member pathways
11.39 BCR STAT3 STAT5B
14
Show member pathways
11.2 STAT3 STAT5B
15 11.2 STAT3 STAT5B
16
Show member pathways
11.17 STAT3 STAT5B
17 11.06 PTEN STAT3 STAT5B
18
Show member pathways
11.01 STAT3 STAT5B
19 10.98 HGF STAT5B
20
Show member pathways
10.76 HGF STAT3 STAT5B
21 10.74 STAT3 STAT5B

GO Terms for Chronic Leukemia

Biological processes related to Chronic Leukemia according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 9.9 GFI1B STAT3 STAT5B WT1
2 lipid metabolic process GO:0006629 9.87 ABCB4 PTEN PTGS2 SOAT1
3 negative regulation of cell proliferation GO:0008285 9.81 PTEN PTGS2 STAT3 WT1
4 negative regulation of apoptotic process GO:0043066 9.77 HGF PTEN STAT3 STAT5B WT1
5 cell proliferation GO:0008283 9.76 GFI1B HGF PTEN STAT3
6 aging GO:0007568 9.75 PTEN PTGS2 STAT3
7 response to drug GO:0042493 9.73 ABCB4 PTEN PTGS2 STAT3
8 positive regulation of cell proliferation GO:0008284 9.72 HGF PTEN PTGS2 STAT3 STAT5B
9 peptidyl-tyrosine phosphorylation GO:0018108 9.71 BCR HGF STAT5B
10 regulation of cell cycle GO:0051726 9.67 BCR PTEN STAT3
11 JAK-STAT cascade GO:0007259 9.59 STAT3 STAT5B
12 platelet-derived growth factor receptor signaling pathway GO:0048008 9.58 BCR PTEN
13 regulation of multicellular organism growth GO:0040014 9.56 STAT3 STAT5B
14 positive regulation of erythrocyte differentiation GO:0045648 9.55 STAT3 STAT5B
15 response to vitamin D GO:0033280 9.52 ABCB4 PTGS2
16 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.48 STAT3 STAT5B
17 response to organic cyclic compound GO:0014070 9.46 ABCB4 PTEN PTGS2 STAT3
18 cellular response to leptin stimulus GO:0044320 9.4 PTEN STAT3
19 maintenance of permeability of blood-brain barrier GO:0035633 9.26 ABCB4 PTGS2
20 response to organic substance GO:0010033 9.26 ABCB4 PTEN PTGS2 STAT3
21 response to estradiol GO:0032355 9.02 ABCB4 PTEN PTGS2 STAT3 STAT5B

Molecular functions related to Chronic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.7 ABCB4 ARL11 BCR GFI1B HGF PTEN
2 protein tyrosine kinase activity GO:0004713 9.33 BCR HGF STAT5B
3 glucocorticoid receptor binding GO:0035259 8.62 STAT3 STAT5B

Sources for Chronic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....