CLL
MCID: CHR090
MIFTS: 63

Chronic Lymphocytic Leukemia (CLL) malady

Immune diseases category

Summaries for Chronic Lymphocytic Leukemia

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic lymphocytic leukemia (cll), there are too many lymphocytes, a type of white blood cell. cll is the second most common type of leukemia in adults. it often occurs during or after middle age, and is rare in children. usually cll does not cause any symptoms. if you have symptoms, they may include painless swelling of the lymph nodes in the neck, underarm, stomach, or groin fatigue pain or a feeling of fullness below the ribs fever and infection weight loss tests that examine the blood, bone marrow, and lymph nodes diagnose cll. your doctor may choose to just monitor you until symptoms appear or change. treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Chronic Lymphocytic Leukemia, also known as leukemia, lymphocytic, chronic, is related to leukemia and prolymphocytic leukemia. An important gene associated with Chronic Lymphocytic Leukemia is SETDB2 (SET domain, bifurcated 2), and among its related pathways is Homologous Recombination Repair. The drugs immunoglobulins, intravenous and cyclophosphamide and the compound imatinib have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow.

Wikipedia:63 B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most... more...

Aliases & Classifications for Chronic Lymphocytic Leukemia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 22GTR, 44Novoseek, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

chronic lymphocytic leukemia 8 42 10 33 30 60
leukemia, lymphocytic, chronic 42 22
leukemia lymphocytic chronic 44
cll 42


External Ids:

Disease Ontology8 DOID:1040
MeSH34 D015451

Related Diseases for Chronic Lymphocytic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia chronic lymphocytic leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.6TCL1A, ZAP70, ATM, CD38, CXCR4, RAD51
2prolymphocytic leukemia31.1ZAP70, ATM, CD38, TCL1A
3myeloma31.1TCL1A, CXCR4, CD38, IGHM
4hodgkin's lymphoma31.0TCL1A, IGHM, ATM, ZAP70
5non-hodgkin lymphoma31.0ATM, CD38, CXCR4, TCL1A
6multiple myeloma31.0CD38
7myeloid leukemia30.9CD38
8b-cell chronic lymphocytic leukemia30.9IGHM, ZAP70
9breast cancer30.3RAD51, ATM
10burkitt's lymphoma30.1ATM, TCL1A
11t-cell leukemia11.0
12richter's syndrome10.8
13hemolytic anemia10.8
14autoimmune hemolytic anemia10.8
15acute leukemia10.8
16acute lymphocytic leukemia10.8
17mantle cell lymphoma10.7
18hairy cell leukemia10.7
19pure red-cell aplasia10.6
20chronic myeloid leukemia10.6
21lymphoid leukemia10.6
22glomerulonephritis10.5
23pemphigus10.5
24cll/sll10.5
25herpes simplex10.5
26acute myeloid leukemia10.5
27merkel cell carcinoma10.5
28diffuse large b-cell lymphoma10.5
29thrombocytopenia10.5
30macroglobulinemia10.5
31central nervous system leukemia10.5
32progressive multifocal leukoencephalopathy10.5
33lymphoblastic leukemia10.5
34cryoglobulinemia10.4
35chronic monocytic leukemia10.4
36composite lymphoma10.4
37b cell deficiency10.4
38monocytic leukemia10.4
39membranoproliferative glomerulonephritis10.4
40postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
41hemophagocytic lymphohistiocytosis10.4
42natural killer cell leukemia10.4
43pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
44melanoma10.4
45squamous cell carcinoma10.4
46graft versus host disease10.3
47polycythemia vera10.3
48gaucher's disease10.3
49central nervous system lymphoma10.3
50ataxia telangiectasia10.3

Graphical network of the top 20 diseases related to Chronic Lymphocytic Leukemia:



Diseases related to chronic lymphocytic leukemia

Clinical Features for Chronic Lymphocytic Leukemia

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Drugs & Therapeutics for Chronic Lymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Chronic Lymphocytic Leukemia

Search NIH Clinical Center for Chronic Lymphocytic Leukemia

Search CenterWatch for Chronic Lymphocytic Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Lymphocytic Leukemia

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22GTR
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Genetic tests related to Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Chronic Lymphocytic Leukemia22

Anatomical Context for Chronic Lymphocytic Leukemia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Chronic Lymphocytic Leukemia:

32
B cells, Bone, Bone marrow, T cells, Lymph node, Testes, Spleen, Myeloid, Endothelial, Skin, Nk cells, Colon, Monocytes, Lung, Kidney, Liver, Breast, Whole blood, Tonsil, Thyroid, Prostate, Smooth muscle, Pituitary, Brain, Testis, Heart

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Chronic Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Chronic Lymphocytic Leukemia or affiliated genes

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Publications for Chronic Lymphocytic Leukemia

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50PubMed
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Articles related to Chronic Lymphocytic Leukemia:

(show top 50)    (show all 2461)
idTitleAuthorsYear
1
Alemtuzumab in chronic lymphocytic leukemia: final results of a large observational multicenter study in mostly pretreated patients. (24292560)
2014
2
Improved detection rate of cytogenetic abnormalities in chronic lymphocytic leukemia and other mature B-cell neoplasms with use of CpG-oligonucleotide DSP30 and interleukin 2 stimulation. (23596118)
2013
3
The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation. (23349302)
2013
4
IgD cross-linking induces gene expression profiling changes and enhances apoptosis in chronic lymphocytic leukemia cells. (23337402)
2013
5
Leukemia Cutis Coexisting With Dermatofibroma as the Initial Presentation of B-cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. (23974225)
2013
6
Atypical Presentation of Genital Herpes Simplex (HSV-2) in Two Patients with Chronic Lymphocytic Leukemia. (23975187)
2013
7
Long-term molecular remission with lenalidomide treatment of relapsed chronic lymphocytic leukemia. (23281656)
2013
8
Toll-like receptor 4 and 9 expression in B-chronic lymphocytic leukemia: relationship with infections, autoimmunity and disease progression. (24144314)
2013
9
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. (23782158)
2013
10
Lenalidomide reduces survival of chronic lymphocytic leukemia cells in primary cocultures by altering the myeloid microenvironment. (23349394)
2013
11
Germline allele-specific expression of DAPK1 in chronic lymphocytic leukemia. (23383130)
2013
12
Expression of miR-15a and miR-16-1 in patients with chronic lymphocytic leukemia. (24026141)
2013
13
Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model. (24100449)
2013
14
Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B-cell receptor signaling. (23264597)
2013
15
Hemophagocytic lymphohistiocytosis associated with influenza A (H1N1) infection in a patient with chronic lymphocytic leukemia: an autopsy case report and review of the literature. (21724431)
2012
16
IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia. (22464020)
2012
17
TOSO is overexpressed and correlated with disease progression in Chinese patients with chronic lymphocytic leukemia. (21133733)
2011
18
Splenic infarction associated with rapidly progressive chronic lymphocytic leukemia with complex karyotype and ATM mutation. (21185599)
2011
19
Accurate reporting of adverse events in chronic lymphocytic leukemia and non-Hodgkin lymphoma. (22361879)
2011
20
Primary cutaneous follicle center lymphoma in the setting of chronic lymphocytic leukemia. (21508570)
2011
21
Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. (21079155)
2011
22
Graft-versus-leukemia effects of Wilms' tumor 1 protein-specific cytotoxic T lymphocytes in patients with chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation. (20497687)
2010
23
Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. (19509140)
2009
24
CD40 ligand, Bcl-2 and apoptosis in B-chronic lymphocytic leukemia. (22059351)
2009
25
Expression of ZAP-70 in patients with chronic lymphocytic leukemia may change significantly during the course of the disease. (18479306)
2008
26
4-arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients. (18922614)
2008
27
The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with thalidomide. (17657216)
2008
28
The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine. (19088025)
2008
29
The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia. (17707831)
2007
30
Development of a Richter syndrome with a monoclonal component from a true B-cell chronic lymphocytic leukemia (B-CLL) treated with fludarabine. (17356849)
2007
31
Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia. (17051526)
2007
32
Comparison of methods for determining zeta-chain associated protein - 70 (ZAP-70) expression in patients with B-cell chronic lymphocytic leukemia (B-CLL). (16906577)
2006
33
Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. (16849395)
2006
34
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. (17178851)
2006
35
Alemtuzumab therapy for severe autoimmune hemolysis in a patient with B-cell chronic lymphocytic leukemia. (16645240)
2006
36
Bone marrow angiogenesis and proliferation in B-cell chronic lymphocytic leukemia. (15560532)
2004
37
Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family. (12781453)
2003
38
Homologous recombinational repair vis-A -vis chlorambucil resistance in chronic lymphocytic leukemia. (12007561)
2002
39
Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. (12010828)
2002
40
Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells. (12384529)
2002
41
Parathyroid hormone-related protein (PTH-rP)-associated hypercalcemia in a patient with an atypical chronic lymphocytic leukemia. (10048292)
1999
42
Chronic neutrophilic leukemia associated with chronic lymphocytic leukemia. (9713172)
1998
43
Revealing some oncofetal antigens in peripheral blood mononuclear cells of donors and patients with B-chronic lymphocytic leukemia. (9783803)
1998
44
CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules. (9096698)
1997
45
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
46
Hypercalcemia in a patient with chronic lymphocytic leukemia evolving into Richter's syndrome. (9172822)
1996
47
Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4. (7919349)
1994
48
Distinct characteristics of lymphokine-activated killer (LAK) cells derived from patients with B-cell chronic lymphocytic leukemia (B-CLL). A factor in B-CLL serum promotes natural killer cell-like LAK cell growth. (2207313)
1990
49
Hepatorenal syndrome complicating chronic lymphocytic leukemia. (3946451)
1986
50
Congestive heart failure and endocardial fibroelastosis caused by chronic lymphocytic leukemia. (7417948)
1980

Genetic Variations for Chronic Lymphocytic Leukemia

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Expression for genes affiliated with Chronic Lymphocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with Chronic Lymphocytic Leukemia

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53Reactome
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Pathways related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8RAD51, ATM

Compounds for genes affiliated with Chronic Lymphocytic Leukemia

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1imatinib44 49 1113.0RAD51, CXCR4, ZAP70

GO Terms for genes affiliated with Chronic Lymphocytic Leukemia

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16Gene Ontology
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Biological processes related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00166611.0CXCR4, CD38, ATM

Products for genes affiliated with Chronic Lymphocytic Leukemia

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Sources for Chronic Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet