CLL
MCID: CHR090
MIFTS: 56

Chronic Lymphocytic Leukemia (CLL) malady

Summaries for Chronic Lymphocytic Leukemia

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic lymphocytic leukemia (cll), there are too many lymphocytes, a type of white blood cell. cll is the second most common type of leukemia in adults. it often occurs during or after middle age, and is rare in children. usually cll does not cause any symptoms. if you have symptoms, they may include painless swelling of the lymph nodes in the neck, underarm, stomach, or groin fatigue pain or a feeling of fullness below the ribs fever and infection weight loss tests that examine the blood, bone marrow, and lymph nodes diagnose cll. your doctor may choose to just monitor you until symptoms appear or change. treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Chronic Lymphocytic Leukemia, also known as leukemia, lymphocytic, chronic, is related to b-cell chronic lymphocytic leukemia and follicular lymphoma. An important gene associated with Chronic Lymphocytic Leukemia is SETDB2 (SET domain, bifurcated 2), and among its related pathways is Homologous Recombination Repair. The drugs mercaptopurine and chlorambucil and the compound imatinib have been mentioned in the context of this disorder.

Wikipedia:64 B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most... more...

Aliases & Classifications for Chronic Lymphocytic Leukemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 22GTR, 45Novoseek, 35MeSH
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Aliases & Descriptions:

chronic lymphocytic leukemia 8 43 10 34 31 61
leukemia, lymphocytic, chronic 43 22
leukemia lymphocytic chronic 45
cll 43


External Ids:

Disease Ontology8 DOID:1040
MeSH35 D015451

Related Diseases for Chronic Lymphocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell chronic lymphocytic leukemia31.8IGHM, ZAP70
2follicular lymphoma30.8ZAP70, IGHM, TCL1A
3b-cell lymphomas30.5ZAP70, ATM, IGHM, TCL1A
4burkitt's lymphoma30.1ZAP70, ATM, IGHM, CD38, CXCR4, TCL1A
5t-cell leukemia11.3
6leukemia, t-cell, chronic11.3
7leukemia, b-cell, chronic11.2
8richter's syndrome11.0
9leukemia, chronic lymphocytic 111.0
10familial chronic lymphocytic leukemia10.9
11autoimmune hemolytic anemia10.8
12leukemia/lymphoma, t-cell10.8
13acute leukemia10.8
14acute lymphocytic leukemia10.8
15mantle cell lymphoma10.7
16plasma cell leukemia10.7
17leukemia, chronic lymphocytic 210.7
18chronic myeloid leukemia10.6
19n syndrome10.6
20lymphoid leukemia10.6
21refractory anemia10.6
22pemphigus10.5
23acute myeloid leukemia10.5
24merkel cell carcinoma10.5
25thrombocytopenia10.5
26chronic myelomonocytic leukemia10.5
27lymphoma, diffuse large cell10.5
28macroglobulinemia10.5
29central nervous system leukemia10.5
30progressive multifocal leukoencephalopathy10.5
31paraneoplastic pemphigus10.5
32cryoglobulinemia10.4
33composite lymphoma10.4
34essential thrombocythemia10.4
35leukemia, chronic lymphocytic 310.4
36membranoproliferative glomerulonephritis10.4
37postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
38hemophagocytic lymphohistiocytosis10.4
39natural killer cell leukemia10.4
40pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
41squamous cell carcinoma10.4
42acute myelomonocytic leukemia10.4
43angiomatosis10.4
44leukemia, chronic lymphocytic 410.4
45t-cell prolymphocytic leukemia10.4
46graft versus host disease10.3
47colon lymphoma10.3
48polycythemia vera10.3
49hepatitis c10.3
50central nervous system lymphoma10.3

Graphical network of the top 20 diseases related to Chronic Lymphocytic Leukemia:



Diseases related to chronic lymphocytic leukemia

Clinical Features for Chronic Lymphocytic Leukemia

Drugs & Therapeutics for Chronic Lymphocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Chronic Lymphocytic Leukemia

Search NIH Clinical Center for Chronic Lymphocytic Leukemia

Search CenterWatch for Chronic Lymphocytic Leukemia

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Lymphocytic Leukemia

Sources:
22GTR
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Genetic tests related to Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Chronic Lymphocytic Leukemia22

Anatomical Context for Chronic Lymphocytic Leukemia

Sources:
31LifeMap Discovery™
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LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Chronic Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Chronic Lymphocytic Leukemia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Chronic Lymphocytic Leukemia

Sources:
51PubMed
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Articles related to Chronic Lymphocytic Leukemia:

(show top 50)    (show all 2433)
idTitleAuthorsYear
1
Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia. (23974981)
2014
2
Minimal residual disease quantification using consensus primers and high-throughput IGH sequencing predicts post-transplant relapse in chronic lymphocytic leukemia. (23419792)
2013
3
Chlorambucil plus Rituximab as Front-Line Therapy in Elderly/Unfit Patients Affected by B-Cell Chronic Lymphocytic Leukemia: Results of a Single-Centre Experience. (23667729)
2013
4
Improvement of paraneoplastic limbic encephalitis after systemic treatment with rituximab in a patient with B-cell chronic lymphocytic leukemia. (23984126)
2013
5
Use of Positron Emission Tomography-Computerized Tomography (PET-CT) in the Management of Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL). (24286263)
2013
6
ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin. (23585524)
2013
7
Autoimmune Cytopenias in Chronic Lymphocytic Leukemia, Facts and Myths. (24363883)
2013
8
MDM2 promoter SNP309 is associated with an increased susceptibility to chronic lymphocytic leukemia and correlates with MDM2 mRNA expression in Chinese patients with CLL. (21647873)
2012
9
Hemophagocytic lymphohistiocytosis associated with influenza A (H1N1) infection in a patient with chronic lymphocytic leukemia: an autopsy case report and review of the literature. (21724431)
2012
10
The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells. (22289918)
2012
11
Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia. (22374828)
2012
12
Frequency and prognostic impact of the aberrant CD8 expression in 5,523 patients with chronic lymphocytic leukemia. (22143984)
2012
13
Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia. (22460735)
2012
14
Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia. (21908424)
2011
15
TOSO is overexpressed and correlated with disease progression in Chinese patients with chronic lymphocytic leukemia. (21133733)
2011
16
An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737. (21772052)
2011
17
Chronic lymphocytic leukemia/small lymphocytic lymphoma with pancytopenia and chylothorax. (21421106)
2011
18
TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. (20861914)
2010
19
ZAP-70 intron1 DNA methylation status: determination by pyrosequencing in B chronic lymphocytic leukemia. (19944462)
2010
20
An unbalanced t(15;18)(q21-q22;p11) as the sole cytogenetic aberration in a patient with B-cell chronic lymphocytic leukemia. (20513537)
2010
21
Most morphologic features in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) do not reliably predict underlying FISH genetics or immunoglobulin heavy chain variable region somatic mutational status. (19826250)
2010
22
The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. (19581935)
2009
23
Familial chronic lymphocytic leukemia: what does it mean to me? (19778840)
2009
24
The MDM2 -309 T/G promoter single nucleotide polymorphism does not alter disease characteristics in chronic lymphocytic leukemia. (18508789)
2008
25
Characterising the TP53-deleted subgroup of chronic lymphocytic leukemia: an analysis of additional cytogenetic abnormalities detected by interphase fluorescence in situ hybridisation and array-based comparative genomic hybridisation. (18949611)
2008
26
Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis. (17526459)
2007
27
The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells. (17339184)
2007
28
HS1 complexes with cytoskeleton adapters in normal and malignant chronic lymphocytic leukemia B cells. (17508001)
2007
29
Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia. (17545520)
2007
30
Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. (16849395)
2006
31
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. (17178851)
2006
32
Flow cytometry for ZAP-70: New colors for chronic lymphocytic leukemia. (16906579)
2006
33
CD38 expression level and pattern of expression remains a reliable and robust marker of progressive disease in chronic lymphocytic leukemia. (17107912)
2006
34
Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia. (16832816)
2006
35
In vitro screening for synergism of high-linear energy transfer 213Bi-radiotherapy with other therapeutic agents for the treatment of B-cell chronic lymphocytic leukemia. (16999602)
2006
36
Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia. (16601244)
2006
37
Recurrent chemotherapy-induced tumor lysis syndrome (TLS) with renal failure in a patient with chronic lymphocytic leukemia - successful treatment and prevention of TLS with low-dose rasburicase. (16313266)
2005
38
Efficacy and tolerability of alemtuzumab (CAMPATH-1H) in the salvage treatment of B-cell chronic lymphocytic leukemia--change of regimen needed? (15101722)
2004
39
The prognostic value of CD38 expression and its quantification in B cell chronic lymphocytic leukemia (B-CLL). (15160906)
2004
40
Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation. (12521993)
2003
41
Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia. (12592341)
2003
42
Importance of prognostic factors in patients with chronic B-lymphocytic leukemia at the time of diagnosis]. (12688180)
2002
43
BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like. (11072235)
2000
44
Revealing some oncofetal antigens in peripheral blood mononuclear cells of donors and patients with B-chronic lymphocytic leukemia. (9783803)
1998
45
Protection from apoptotic cell death by interleukin-4 is increased in previously treated chronic lymphocytic leukemia patients. (9029180)
1997
46
CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM. (9108402)
1997
47
Incidence of 5' bcl-2 rearrangement in patients with B cell chronic lymphocytic leukemia from India. (8947590)
1996
48
Expression of cell cycle regulatory proteins in chronic lymphocytic leukemias. Comparison with non-Hodgkin's lymphomas and non-neoplastic lymphoid tissue. (7643628)
1995
49
Clinicopathological and immunophenotypic studies on 12 cases with B cell chronic lymphocytic leukemia. (7834079)
1994
50
Differential effects of the stimulation of complement receptors CR1 (CD35) and CR2 (CD21) on cell proliferation and intracellular Ca2+ mobilization of chronic lymphocytic leukemia B cells. (1826011)
1991

Genetic Variations for Chronic Lymphocytic Leukemia

Expression for genes affiliated with Chronic Lymphocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with Chronic Lymphocytic Leukemia

Sources:
54Reactome
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Pathways related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8RAD51, ATM

Compounds for genes affiliated with Chronic Lymphocytic Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1imatinib45 50 1113.0RAD51, CXCR4, ZAP70

GO Terms for genes affiliated with Chronic Lymphocytic Leukemia

Sources:
16Gene Ontology
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Biological processes related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00166611.0CXCR4, CD38, ATM

Products for genes affiliated with Chronic Lymphocytic Leukemia

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Sources for Chronic Lymphocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet