CLL
MCID: CHR090
MIFTS: 67

Chronic Lymphocytic Leukemia (CLL) malady

Genetic diseases, Rare diseases, Cancer diseases, Immune diseases, Blood diseases categories

Summaries for Chronic Lymphocytic Leukemia

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35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic lymphocytic leukemia (cll), there are too many lymphocytes, a type of white blood cell. cll is the second most common type of leukemia in adults. it often occurs during or after middle age, and is rare in children. usually cll does not cause any symptoms. if you have symptoms, they may include painless swelling of the lymph nodes in the neck, underarm, stomach, or groin fatigue pain or a feeling of fullness below the ribs fever and infection weight loss tests that examine the blood, bone marrow, and lymph nodes diagnose cll. your doctor may choose to just monitor you until symptoms appear or change. treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Chronic Lymphocytic Leukemia, also known as leukemia, lymphocytic, chronic, is related to leukemia and b-cell chronic lymphocytic leukemia. An important gene associated with Chronic Lymphocytic Leukemia is SETDB2 (SET domain, bifurcated 2), and among its related pathways are Homologous recombination and BARD1 signaling events. The drugs immunoglobulins, intravenous and cyclophosphamide and the compounds rituximab and imatinib have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow.

Wikipedia:66 B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most... more...

Aliases & Classifications for Chronic Lymphocytic Leukemia

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 23GTR, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 36MeSH
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Classifications:



Aliases & Descriptions:

chronic lymphocytic leukemia 9 44 11 35 32 63
leukemia, lymphocytic, chronic 44 23
leukemia lymphocytic chronic 46
cll 44


External Ids:

Disease Ontology9 DOID:1040
MeSH36 D015451

Related Diseases for Chronic Lymphocytic Leukemia

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia chronic lymphocytic leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 249)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.7ATM, IGH, CXCR4, RAD51, ZAP70, CD38
2b-cell chronic lymphocytic leukemia32.3IGH, IGHM, ZAP70
3prolymphocytic leukemia31.3CD38, ZAP70, ATM
4myeloma31.2CD38, CXCR4, TNFSF13B, IGHM, IGH
5non-hodgkin lymphoma31.2ATM, IGH, TNFSF13B, CXCR4, CD38
6hodgkin's lymphoma31.1ATM, IGH, IGHM, TNFSF13B, ZAP70
7b-cell lymphomas31.1ATM, IGH, IGHM, TNFSF13B, ZAP70
8follicular lymphoma30.9ZAP70, IGHM, IGH
9t-cell leukemia30.6ZAP70, IGH, ATM
10acute lymphocytic leukemia30.4IGH, CXCR4, ZAP70, CD38
11acute leukemia30.4ATM, IGH, CXCR4
12breast cancer30.3ATM, RAD51
13severe combined immunodeficiency30.3CXCR4, ZAP70, CD38
14burkitt's lymphoma30.1ATM, IGH, IGHM, TNFSF13B, CXCR4, ZAP70
15richter's syndrome10.9
16hemolytic anemia10.9
17autoimmune hemolytic anemia10.8
18familial chronic lymphocytic leukemia10.8
19mantle cell lymphoma10.7
20hairy cell leukemia10.7
21multiple myeloma10.7
22endotheliitis10.7
23pure red-cell aplasia10.7
24pemphigus10.5
25cll/sll10.5
26glomerulonephritis10.5
27herpes simplex10.5
28myeloid leukemia10.5
29diffuse large b-cell lymphoma10.5
30merkel cell carcinoma10.5
31thrombocytopenia10.5
32progressive multifocal leukoencephalopathy10.5
33macroglobulinemia10.5
34paraneoplastic pemphigus10.5
35cryoglobulinemia10.4
36acute myeloid leukemia10.4
37lymphoblastic leukemia10.4
38essential thrombocythemia10.4
39postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
40pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
41hemophagocytic lymphohistiocytosis10.4
42melanoma10.4
43chronic myelomonocytic leukemia10.4
44angiomatosis10.4
45graft versus host disease10.3
46gaucher's disease10.3
47polycythemia vera10.3
48membranoproliferative glomerulonephritis10.3
49chronic myeloid leukemia10.3
50hypercalcemia10.3

Graphical network of the top 20 diseases related to Chronic Lymphocytic Leukemia:



Diseases related to chronic lymphocytic leukemia

Symptoms for Chronic Lymphocytic Leukemia

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Drugs & Therapeutics for Chronic Lymphocytic Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Chronic Lymphocytic Leukemia

Search NIH Clinical Center for Chronic Lymphocytic Leukemia

Search CenterWatch for Chronic Lymphocytic Leukemia

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Lymphocytic Leukemia

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23GTR
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Genetic tests related to Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Chronic Lymphocytic Leukemia23

Anatomical Context for Chronic Lymphocytic Leukemia

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Chronic Lymphocytic Leukemia:

34
B cells, Bone, Bone marrow, T cells, Lymph node, Testes, Spleen, Endothelial, Myeloid, Skin, Nk cells, Colon, Monocytes, Breast, Lung, Liver, Thyroid, Whole blood, Kidney, Tonsil, Prostate, Testis, Smooth muscle, Heart, Brain, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Chronic Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Chronic Lymphocytic Leukemia or affiliated genes

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Publications for Chronic Lymphocytic Leukemia

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53PubMed
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Articles related to Chronic Lymphocytic Leukemia:

(show top 50)    (show all 2373)
idTitleAuthorsYear
1
Reply to myelosuppression after frontline fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia: Analysis of Persistent and New-Onset Cytopenia. (24151154)
2013
2
Increased frequency of CD8+ and CD4+ regulatory T cells in chronic lymphocytic leukemia: association with disease progression. (23286587)
2013
3
Improving but inferior survival in patients with chronic lymphocytic leukemia in taiwan: a population-based study, 1990-2004. (23638168)
2013
4
Concomitant JAK2 V617F-positive polycythemia vera and B-cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells. (23280542)
2013
5
DNA repair initiation induces expression of ribonucleotide reductase in human chronic lymphocytic leukemia cells. (23772636)
2013
6
Richter syndrome: chronic lymphocytic leukemia transformation into Hodgkin's disease. (24266095)
2013
7
Ibrutinib in relapsed chronic lymphocytic leukemia. (24066758)
2013
8
The significance of stereotyped B-cell receptors in chronic lymphocytic leukemia. (23561471)
2013
9
High CD74 expression correlates with ZAP70 expression in B cell chronic lymphocytic leukemia patients. (23572149)
2013
10
Cutaneous metastasis of gallbladder adenocarcinoma in a patient with chronic lymphocytic leukemia: a case report and review of the literature. (23467457)
2013
11
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions. (23071276)
2012
12
miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. (22350415)
2012
13
CD69 is independently prognostic in chronic lymphocytic leukemia: a comprehensive clinical and biological profiling study. (21993667)
2012
14
Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia. (21908424)
2011
15
TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. (20861914)
2010
16
IGHV3-21 gene usage is associated with high TCL1 expression in chronic lymphocytic leukemia. (19889012)
2010
17
Infrequent occurrence of PIK3CA mutations in chronic lymphocytic leukemia. (19330652)
2009
18
Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade. (18838168)
2009
19
Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. (19509140)
2009
20
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. (17928528)
2008
21
Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. (18396212)
2008
22
Familial chronic lymphocytic leukemia. (20425469)
2008
23
Construction, expression and in vitro biological effects of idiotype Ig Fab fragment of B-chronic lymphocytic leukemia. (18846324)
2008
24
Expression of CLLU1 in patients with chronic lymphocytic leukemia and its prognostic significance]. (18457263)
2007
25
Aberrant expression of T-cell-associated markers CD4 and CD7 on B-cell chronic lymphocytic leukemia. (17019687)
2007
26
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a. (17496928)
2007
27
Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis. (17526459)
2007
28
Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells. (18035318)
2007
29
The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia. (16923552)
2006
30
Sequential fluorescence in situ hybridization analysis for trisomy 12 in B-cell chronic lymphocytic leukemia. (15998971)
2005
31
Circulating vascular endothelial growth factor (VEGF) and its soluble receptors in patients with chronic lymphocytic leukemia. (15809205)
2005
32
Cyclin D expression in chronic lymphocytic leukemia. (16109604)
2005
33
Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. (15068894)
2004
34
Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. (15370211)
2004
35
ATM mutations in B-cell chronic lymphocytic leukemia. (14754616)
2004
36
Cyclic lymphocytic vasculitis associated with chronic lymphocytic leukemia. (15160961)
2004
37
TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. (15545599)
2004
38
Hodgkin's type of Richter's syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide. (12802926)
2003
39
Cytokine modulation of nuclear factor-kappaB activity in B-chronic lymphocytic leukemia. (12644014)
2003
40
Homologous recombinational repair vis-A -vis chlorambucil resistance in chronic lymphocytic leukemia. (12007561)
2002
41
Peripheral blood CD38 expression predicts time to progression in B-cell chronic lymphocytic leukemia after first-line therapy with high-dose chlorambucil. (11836173)
2002
42
CAMPATH (alemtuzumab) for the treatment of chronic lymphocytic leukemia and beyond. (12113063)
2002
43
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. (11929788)
2002
44
Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome. (11133769)
2001
45
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. (11313271)
2001
46
The activation of intracellular tyrosine kinases by interferon-alpha (IFNalpha) correlates with its antiproliferative activity in B-lymphoid cell lines, but not in B-cell chronic lymphocytic leukemia patients. (10803933)
2000
47
p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. (9596683)
1998
48
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
49
Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. (8786328)
1996
50
Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by fluorescence in situ hybridization. (7627948)
1995

Variations for Chronic Lymphocytic Leukemia

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Expression for genes affiliated with Chronic Lymphocytic Leukemia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with Chronic Lymphocytic Leukemia

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 54QIAGEN
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Pathways related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Homologous recombination39
10.2RAD51, ATM
210.2RAD51, ATM
3
Show member pathways
10.2ATM, RAD51
410.0ATM, TNFSF13B, ZAP70
5
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
9.9ZAP70, IGHM, IGH
6
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.8ZAP70, CXCR4, IGHM, IGH
7
Show member pathways
9.7TNFSF13B, CXCR4, RAD51, ZAP70, ATM

Compounds for genes affiliated with Chronic Lymphocytic Leukemia

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR
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Compounds related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rituximab46 52 1212.2CD38, ZAP70, TNFSF13B
2imatinib46 52 1212.1ZAP70, RAD51, CXCR4
3aphidicolin4610.1RAD51, ATM
4polyacrylamide469.9RAD51, IGH, ATM
5atp46 3010.8ATM, CXCR4, RAD51, ZAP70, CD38
6ethidium bromide469.8IGH, RAD51
7tyrosine469.6ATM, FCRL2, CXCR4, RAD51, ZAP70, CD38

GO Terms for genes affiliated with Chronic Lymphocytic Leukemia

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17Gene Ontology
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Biological processes related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adaptive immune responseGO:00225010.2ZAP70, IGHM
2reciprocal meiotic recombinationGO:00713110.1RAD51, ATM
3response to hypoxiaGO:00166610.1CD38, CXCR4, ATM
4positive regulation of B cell proliferationGO:0308909.9CD38, TNFSF13B

Products for genes affiliated with Chronic Lymphocytic Leukemia

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  • Antibodies
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Sources for Chronic Lymphocytic Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet