CLL
MCID: CHR090
MIFTS: 63

Chronic Lymphocytic Leukemia (CLL) malady

Immune diseases category

Summaries for Chronic Lymphocytic Leukemia

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic lymphocytic leukemia (cll), there are too many lymphocytes, a type of white blood cell. cll is the second most common type of leukemia in adults. it often occurs during or after middle age, and is rare in children. usually cll does not cause any symptoms. if you have symptoms, they may include painless swelling of the lymph nodes in the neck, underarm, stomach, or groin fatigue pain or a feeling of fullness below the ribs fever and infection weight loss tests that examine the blood, bone marrow, and lymph nodes diagnose cll. your doctor may choose to just monitor you until symptoms appear or change. treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Chronic Lymphocytic Leukemia, also known as leukemia, lymphocytic, chronic, is related to leukemia and prolymphocytic leukemia. An important gene associated with Chronic Lymphocytic Leukemia is SETDB2 (SET domain, bifurcated 2), and among its related pathways is Homologous Recombination Repair. The drugs mercaptopurine and chlorambucil and the compound imatinib have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow.

Wikipedia:63 B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most... more...

Aliases & Classifications for Chronic Lymphocytic Leukemia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

chronic lymphocytic leukemia 8 42 10 33 30 60
leukemia, lymphocytic, chronic 42 22
leukemia lymphocytic chronic 44
cll 42


External Ids:

Disease Ontology8 DOID:1040
MeSH34 D015451

Related Diseases for Chronic Lymphocytic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia chronic lymphocytic leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.6TCL1A, ZAP70, ATM, CD38, CXCR4, RAD51
2prolymphocytic leukemia31.1ZAP70, ATM, CD38, TCL1A
3myeloma31.1TCL1A, CXCR4, CD38, IGHM
4hodgkin's lymphoma31.0TCL1A, IGHM, ATM, ZAP70
5non-hodgkin lymphoma31.0ATM, CD38, CXCR4, TCL1A
6multiple myeloma31.0CD38
7myeloid leukemia30.9CD38
8b-cell chronic lymphocytic leukemia30.9IGHM, ZAP70
9breast cancer30.3RAD51, ATM
10burkitt's lymphoma30.1ATM, TCL1A
11t-cell leukemia11.0
12richter's syndrome10.8
13hemolytic anemia10.8
14autoimmune hemolytic anemia10.8
15acute leukemia10.8
16acute lymphocytic leukemia10.8
17mantle cell lymphoma10.7
18hairy cell leukemia10.7
19pure red-cell aplasia10.6
20chronic myeloid leukemia10.6
21lymphoid leukemia10.6
22glomerulonephritis10.5
23pemphigus10.5
24cll/sll10.5
25herpes simplex10.5
26acute myeloid leukemia10.5
27merkel cell carcinoma10.5
28diffuse large b-cell lymphoma10.5
29thrombocytopenia10.5
30macroglobulinemia10.5
31central nervous system leukemia10.5
32progressive multifocal leukoencephalopathy10.5
33lymphoblastic leukemia10.5
34cryoglobulinemia10.4
35chronic monocytic leukemia10.4
36composite lymphoma10.4
37b cell deficiency10.4
38monocytic leukemia10.4
39membranoproliferative glomerulonephritis10.4
40postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
41hemophagocytic lymphohistiocytosis10.4
42natural killer cell leukemia10.4
43pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
44melanoma10.4
45squamous cell carcinoma10.4
46graft versus host disease10.3
47polycythemia vera10.3
48gaucher's disease10.3
49central nervous system lymphoma10.3
50ataxia telangiectasia10.3

Graphical network of the top 20 diseases related to Chronic Lymphocytic Leukemia:



Diseases related to chronic lymphocytic leukemia

Clinical Features for Chronic Lymphocytic Leukemia

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Drugs & Therapeutics for Chronic Lymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Chronic Lymphocytic Leukemia

Search NIH Clinical Center for Chronic Lymphocytic Leukemia

Search CenterWatch for Chronic Lymphocytic Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Lymphocytic Leukemia

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22GTR
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Genetic tests related to Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Chronic Lymphocytic Leukemia22

Anatomical Context for Chronic Lymphocytic Leukemia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Chronic Lymphocytic Leukemia:

32
B cells, Bone, Bone marrow, T cells, Lymph node, Testes, Spleen, Myeloid, Endothelial, Skin, Nk cells, Colon, Monocytes, Breast, Kidney, Lung, Liver, Whole blood, Thyroid, Tonsil, Prostate, Testis, Smooth muscle, Heart, Brain, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Chronic Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Chronic Lymphocytic Leukemia or affiliated genes

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Publications for Chronic Lymphocytic Leukemia

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50PubMed
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Articles related to Chronic Lymphocytic Leukemia:

(show top 50)    (show all 2461)
idTitleAuthorsYear
1
Utility of positron emission tomography/computed tomography for nodal staging of cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia. (24051234)
2014
2
Morphology and expression status investigations of specific surface markers on B-cell chronic lymphocytic leukemia cells. (23963997)
2013
3
Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients. (23860447)
2013
4
IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. (23840319)
2013
5
miR-29c down-regulation is associated with disease aggressiveness and poor survival in Chinese patients with chronic lymphocytic leukemia. (24138306)
2013
6
Clonal evolution in chronic lymphocytic leukemia: analysis of correlations with IGHV mutational status, NOTCH1 mutations and clinical significance. (23893575)
2013
7
Signaling the end of chronic lymphocytic leukemia: new frontline treatment strategies. (24319175)
2013
8
Uncoupling endoplasmic reticulum stress and autophagy: a potential implication for chronic lymphocytic leukemia therapy. (23656199)
2013
9
B-cell antigen receptor signaling in chronic lymphocytic leukemia: therapeutic targets and translational opportunities. (23886341)
2013
10
The role of bone marrow biopsy examination at diagnosis of chronic lymphocytic leukemia: a reappraisal. (23485170)
2013
11
MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. (22234685)
2012
12
A rare case of B-cell chronic lymphocytic leukemia with t(2;14)(p13;q32), +X, +11, +12, +13,+der(1p) karyotype. (21921357)
2011
13
Concurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma treated with fludarabine: a dimorphic presentation of iatrogenic immunodeficiency-associated lymphoproliferative disorder with evidence suggestive of multiclonal transformability of B cells by Epstein-Barr virus. (20869749)
2010
14
High expression of lymphocyte-activation gene 3 (LAG3) in chronic lymphocytic leukemia cells is associated with unmutated immunoglobulin variable heavy chain region (IGHV) gene and reduced treatment-free survival. (20228263)
2010
15
Analysis of the REL, BCL11A, and MYCN proto-oncogenes belonging to the 2p amplicon in chronic lymphocytic leukemia. (20575024)
2010
16
Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia. (20487546)
2010
17
Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia. (19452318)
2009
18
Translocation t(2;8)(p12;q24) in two patients with B Cell chronic lymphocytic leukemia. (19246886)
2008
19
Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia. (18618518)
2008
20
Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia. (18695923)
2008
21
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. (17875758)
2007
22
Fludarabine-associated autoimmune hemolytic anemia occurring in B-cell chronic lymphocytic leukemia. (16542723)
2006
23
Significance of zeta-associated protein (ZAP-70) and CD38 expression in chronic lymphocytic leukemia. (18689273)
2006
24
The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. (15802533)
2005
25
Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival. (15738539)
2005
26
ZAP-70 staining in chronic lymphocytic leukemia. (18770822)
2005
27
Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. (15905192)
2005
28
Therapy of chronic lymphocytic leukemia with purine analogs and monoclonal antibodies. (15737872)
2005
29
ZAP-70 methylation and expression status in chronic lymphocytic leukemia. (16079094)
2005
30
Equilibrative nucleoside transporter-2 (hENT2) protein expression correlates with ex vivo sensitivity to fludarabine in chronic lymphocytic leukemia (CLL) cells. (15510196)
2005
31
PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia. (16225771)
2004
32
Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. (12411296)
2003
33
The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro. (12446453)
2003
34
Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia. (12689926)
2003
35
Alkylating agents and nucleoside analogues in the treatment of B cell chronic lymphocytic leukemia. (12040433)
2002
36
Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells. (12454749)
2002
37
Rituximab-based chemotherapy for steroid-refractory autoimmune hemolytic anemia of chronic lymphocytic leukemia. (12357362)
2002
38
Immunoglobulin heavy chain variable region (VH) genes of B cell chronic lymphocytic leukemia cells from lymph nodes show somatic mutations and intraclonal diversity irrespective of follicular dendritic cell network. (11699415)
2001
39
Plasmablastic lymphoma in a patient with chronic lymphocytic leukemia heavily pretreated with cladribine (2-CdA): an unusual variant of Richter's syndrome. (11872081)
2001
40
Laboratory, morphologic, and immunophenotypic correlates of surface immunoglobulin heavy chain isotype expression in B-cell chronic lymphocytic leukemia. (11764081)
2001
41
Broad alterations of self-reactive antibody-repertoires of plasma IgM and IgG in B-cell chronic lymphocytic leukemia (B-CLL) and B-CLL related target-restricted autoimmunity. (11699204)
2001
42
Angiogenesis in B-cell chronic lymphocytic leukemia: methods of study, clinical significance and prognostic implications. (11697488)
2001
43
Chronic lymphocytic leukemia and hairy-cell leukemia-diagnosis and treatment: results of a consensus meeting of the German CLL Co-operative Group. (9178830)
1997
44
Pure red-cell aplasia requiring cytotoxic chemotherapy: presence of clonal T-lymphocytes without characteristics of chronic lymphocytic leukemia. (8892747)
1996
45
Clinical and hematologic response of chronic lymphocytic and prolymphocytic leukemia persisting after allogeneic bone marrow transplantation with the onset of acute graft-versus-host disease: possible role of graft-versus-leukemia. (8704689)
1996
46
Immunophenotypic and molecular genetic characterization of a case of CD8+ B cell chronic lymphocytic leukemia. (8751478)
1996
47
A unique spectrum of p53 mutations in B-cell chronic lymphocytic leukemia distinct from that of other lymphoid malignancies. (8519411)
1995
48
CD5+, CD11C+, trap-positive chronic lymphocytic leukemia/prolymphocytic leukemia. (1379851)
1992
49
CD5 negative IGM rheumatoid factor B cells in B-chronic lymphocytic leukemia and benign mixed cryoglobulinemia. (1282064)
1992
50
Clonal analysis of bcr-abl rearrangement in T lymphocytes from patients with chronic myelogenous leukemia. (1371078)
1992

Genetic Variations for Chronic Lymphocytic Leukemia

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Expression for genes affiliated with Chronic Lymphocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with Chronic Lymphocytic Leukemia

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53Reactome
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Pathways related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8RAD51, ATM

Compounds for genes affiliated with Chronic Lymphocytic Leukemia

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1imatinib44 49 1113.0RAD51, CXCR4, ZAP70

GO Terms for genes affiliated with Chronic Lymphocytic Leukemia

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16Gene Ontology
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Biological processes related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00166611.0CXCR4, CD38, ATM

Products for genes affiliated with Chronic Lymphocytic Leukemia

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Sources for Chronic Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet