CLL
MCID: CHR090
MIFTS: 89

Chronic Lymphocytic Leukemia (CLL) malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories
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Summaries for Chronic Lymphocytic Leukemia

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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic lymphocytic leukemia (cll), there are too many lymphocytes, a type of white blood cell. cll is the second most common type of leukemia in adults. it often occurs during or after middle age, and is rare in children. usually cll does not cause any symptoms. if you have symptoms, they may include painless swelling of the lymph nodes in the neck, underarm, stomach, or groin fatigue pain or a feeling of fullness below the ribs fever and infection weight loss tests that examine the blood, bone marrow, and lymph nodes diagnose cll. your doctor may choose to just monitor you until symptoms appear or change. treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Chronic Lymphocytic Leukemia, also known as b-cell chronic lymphocytic leukemia, is related to leukemia and prolymphocytic leukemia, and has symptoms including An important gene associated with Chronic Lymphocytic Leukemia is ATM (ataxia telangiectasia mutated), and among its related pathways are TP53 network and Cell cycle Role of 14 3 3 proteins in cell cycle regulation. The drugs immunoglobulins, intravenous and cyclophosphamide and the compounds aphidicolin and melphalan have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow, and related mouse phenotypes are hematopoietic system and embryogenesis.

Disease Ontology:8 A lymphoblastic leukemia characterized by over production of b-cells and their accumulation in bone marrow and blood.

Wikipedia:65 B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most... more...

Descriptions from OMIM:46 609630, 612559, 109543, 612558, 151400 612557 more

Aliases & Classifications for Chronic Lymphocytic Leukemia

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 33MedlinePlus, 62UMLS, 48Orphanet, 46OMIM, 22GTR, 44Novoseek, 34MeSH, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
See all sources

Chronic Lymphocytic Leukemia, Aliases & Descriptions:

Name: Chronic Lymphocytic Leukemia 30 8 42 10 33 62
B-Cell Chronic Lymphocytic Leukemia 8 48 46
Lymphoplasmacytic Leukemia 8 48 62
B-Cell Chronic Lymphoid Leukemia 48 62
Leukemia, Lymphocytic, Chronic 42 22
Cll 8 42
B-Cell Chronic Lymphocytic Leukaemia 62
Lymphocytic Leukemia Chronic B-Cell 44
 
Lymphoplasmacytoid Immunocytoma 48
Leukemia Lymphocytic Chronic 44
Lymphoma, Small Lymphocytic 62
Chronic Lymphatic Leukaemia 62
Small Lymphocytic Lymphoma 48
Chronic Lymphatic Leukemia 8
B-Cll 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
b-cell chronic lymphocytic leukemia:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:1040
MeSH34 D015451
ICD10 via Orphanet26 C91.1
UMLS via Orphanet63 C0023434
MESH via Orphanet35 D015451
ICD1025 C91.1

Related Diseases for Chronic Lymphocytic Leukemia

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Diseases in the Chronic Lymphocytic Leukemia family:

Acute Lymphocytic Leukemia Adult Acute Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 281)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.7ATM, TP53, CXCR4, CCND1, RAD51, CD38
2prolymphocytic leukemia31.5CD38, CCND1, ATM
3mantle cell lymphoma31.5ATM, CCND1
4myeloma31.5TNFSF13B, CXCR4, CCND1, CD38
5non-hodgkin lymphoma31.4ATM, TNFSF13B, CXCR4, CCND1, CD38
6b-cell lymphomas31.1ATM, TNFSF13B, TP53, CCND1
7multiple myeloma31.0CD38, CCND1, TP53
8ataxia telangiectasia31.0RAD51, TP53, ATM
9burkitt's lymphoma30.4CCND1, ATM
10adenoma30.4ATM, TP53, CXCR4, CCND1, RAD51
11glioblastoma30.1ATM, TP53, CXCR4, CCND1
12non-small cell lung carcinoma30.1TP53, CXCR4, CCND1, RAD51
13prostate cancer29.9RAD51, CCND1, CXCR4, TP53, ATM
14breast cancer29.9ATM, TP53, CXCR4, CCND1, BTG1, RAD51
15richter's syndrome10.9
16hemolytic anemia10.9
17autoimmune hemolytic anemia10.9
18familial chronic lymphocytic leukemia10.9
19hodgkin's lymphoma10.8
20hairy cell leukemia10.7
21endotheliitis10.7
22pure red-cell aplasia10.7
23glomerulonephritis10.6
24pemphigus10.6
25merkel cell carcinoma10.6
26cll/sll10.6
27bilateral breast cancer10.6ATM, RAD51
28lymphoid leukemia10.6
29follicular lymphoma10.6
30herpes simplex10.6
31myeloid leukemia10.6
32diffuse large b-cell lymphoma10.5
33thrombocytopenia10.5
34paraneoplastic pemphigus10.5
35agammaglobulinemia10.5CD38, CXCR4
36macroglobulinemia10.5
37human immunodeficiency virus infectious disease10.5CD38, CXCR4
38acute lymphoblastic leukemia10.5
39acute myeloid leukemia10.5
40cryoglobulinemia10.5
41progressive multifocal leukoencephalopathy10.5
42lymphoblastic leukemia10.5
43essential thrombocythemia10.5
44chronic myelomonocytic leukemia10.4
45graft versus host disease10.4
46hemophagocytic lymphohistiocytosis10.4
47postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
48membranoproliferative glomerulonephritis10.4
49pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
50melanoma10.4

Graphical network of the top 20 diseases related to Chronic Lymphocytic Leukemia:



Diseases related to chronic lymphocytic leukemia

Symptoms for Chronic Lymphocytic Leukemia

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Symptoms by clinical synopsis from OMIM:

109543

Clinical features from OMIM:

609630,612559,109543,612558,151400,612557

HPO human phenotypes related to Chronic Lymphocytic Leukemia:

(show all 6)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 chronic lymphatic leukemia HP:0005550
3 somatic mutation HP:0001428
4 autosomal dominant somatic cell mutation HP:0001444
5 abnormality of metabolism/homeostasis HP:0001939
6 chronic lymphatic leukemia HP:0005550

Drugs & Therapeutics for Chronic Lymphocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Chronic Lymphocytic Leukemia

Search NIH Clinical Center for Chronic Lymphocytic Leukemia

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Lymphocytic Leukemia

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Genetic tests related to Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Chronic Lymphocytic Leukemia22

Anatomical Context for Chronic Lymphocytic Leukemia

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MalaCards organs/tissues related to Chronic Lymphocytic Leukemia:

32
B cells, Bone, Bone marrow, T cells, Lymph node, Testes, Spleen, Endothelial, Myeloid, Skin, Nk cells, Colon, Monocytes, Liver, Lung, Breast, Whole blood, Kidney, Thyroid, Prostate, Tonsil, Neutrophil, Brain, Heart, Smooth muscle, Testis, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Chronic Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Chronic Lymphocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Chronic Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.3CD38, CCND1, CXCR4, TP53, TNFSF13B, IGHG1
2MP:000538010.2RAD51, CXCR4, BRWD3, POT1, TP53, ATM
3MP:000538210.0TP53, BRWD3, CHST11, CXCR4, CCND1

Publications for Chronic Lymphocytic Leukemia

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Articles related to Chronic Lymphocytic Leukemia:

(show top 50)    (show all 2410)
idTitleAuthorsYear
1
Population Pharmacokinetics of Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma and Exposure-Response in CLL. (25353187)
2014
2
Reply to myelosuppression after frontline fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia: Analysis of Persistent and New-Onset Cytopenia. (24151154)
2013
3
Increased frequency of CD8+ and CD4+ regulatory T cells in chronic lymphocytic leukemia: association with disease progression. (23286587)
2013
4
Improving but inferior survival in patients with chronic lymphocytic leukemia in taiwan: a population-based study, 1990-2004. (23638168)
2013
5
Concomitant JAK2 V617F-positive polycythemia vera and B-cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells. (23280542)
2013
6
DNA repair initiation induces expression of ribonucleotide reductase in human chronic lymphocytic leukemia cells. (23772636)
2013
7
Richter syndrome: chronic lymphocytic leukemia transformation into Hodgkin's disease. (24266095)
2013
8
Ibrutinib in relapsed chronic lymphocytic leukemia. (24066758)
2013
9
The significance of stereotyped B-cell receptors in chronic lymphocytic leukemia. (23561471)
2013
10
High CD74 expression correlates with ZAP70 expression in B cell chronic lymphocytic leukemia patients. (23572149)
2013
11
Cutaneous metastasis of gallbladder adenocarcinoma in a patient with chronic lymphocytic leukemia: a case report and review of the literature. (23467457)
2013
12
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions. (23071276)
2012
13
miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. (22350415)
2012
14
CD69 is independently prognostic in chronic lymphocytic leukemia: a comprehensive clinical and biological profiling study. (21993667)
2012
15
Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia. (21908424)
2011
16
TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. (20861914)
2010
17
IGHV3-21 gene usage is associated with high TCL1 expression in chronic lymphocytic leukemia. (19889012)
2010
18
Infrequent occurrence of PIK3CA mutations in chronic lymphocytic leukemia. (19330652)
2009
19
Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade. (18838168)
2009
20
Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. (19509140)
2009
21
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. (17928528)
2008
22
Familial chronic lymphocytic leukemia. (20425469)
2008
23
Construction, expression and in vitro biological effects of idiotype Ig Fab fragment of B-chronic lymphocytic leukemia. (18846324)
2008
24
Expression of CLLU1 in patients with chronic lymphocytic leukemia and its prognostic significance]. (18457263)
2007
25
Aberrant expression of T-cell-associated markers CD4 and CD7 on B-cell chronic lymphocytic leukemia. (17019687)
2007
26
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a. (17496928)
2007
27
Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis. (17526459)
2007
28
Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells. (18035318)
2007
29
The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia. (16923552)
2006
30
Sequential fluorescence in situ hybridization analysis for trisomy 12 in B-cell chronic lymphocytic leukemia. (15998971)
2005
31
Circulating vascular endothelial growth factor (VEGF) and its soluble receptors in patients with chronic lymphocytic leukemia. (15809205)
2005
32
Cyclin D expression in chronic lymphocytic leukemia. (16109604)
2005
33
Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. (15068894)
2004
34
Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. (15370211)
2004
35
ATM mutations in B-cell chronic lymphocytic leukemia. (14754616)
2004
36
Cyclic lymphocytic vasculitis associated with chronic lymphocytic leukemia. (15160961)
2004
37
TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. (15545599)
2004
38
Hodgkin's type of Richter's syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide. (12802926)
2003
39
Cytokine modulation of nuclear factor-kappaB activity in B-chronic lymphocytic leukemia. (12644014)
2003
40
Homologous recombinational repair vis-A -vis chlorambucil resistance in chronic lymphocytic leukemia. (12007561)
2002
41
Peripheral blood CD38 expression predicts time to progression in B-cell chronic lymphocytic leukemia after first-line therapy with high-dose chlorambucil. (11836173)
2002
42
CAMPATH (alemtuzumab) for the treatment of chronic lymphocytic leukemia and beyond. (12113063)
2002
43
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. (11929788)
2002
44
Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome. (11133769)
2001
45
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. (11313271)
2001
46
The activation of intracellular tyrosine kinases by interferon-alpha (IFNalpha) correlates with its antiproliferative activity in B-lymphoid cell lines, but not in B-cell chronic lymphocytic leukemia patients. (10803933)
2000
47
p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. (9596683)
1998
48
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
49
Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. (8786328)
1996
50
Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by fluorescence in situ hybridization. (7627948)
1995

Variations for Chronic Lymphocytic Leukemia

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Expression for genes affiliated with Chronic Lymphocytic Leukemia

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Expression patterns in normal tissues for genes affiliated with Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with Chronic Lymphocytic Leukemia

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Pathways related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.4ATM, TP53
2
Show member pathways
10.4TP53, ATM
310.4TP53, ATM
410.4ATM, TP53
510.4TP53, CCND1
6
Show member pathways
Homologous recombination37
10.4RAD51, ATM
7
Show member pathways
10.4RAD51, ATM
8
Show member pathways
10.4CCND1, TP53, ATM
910.4CCND1, TP53, ATM
10
Show member pathways
Cell cycle37
10.4CCND1, TP53, ATM
11
Show member pathways
10.4ATM, TP53, CCND1
1210.4ATM, TP53, CCND1
13
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
10.4CCND1, TP53, ATM
14
Show member pathways
Signaling Pathways in Glioblastoma37
10.4ATM, TP53, CCND1
15
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
10.4ATM, TP53, CCND1
1610.4CCND1, TP53, ATM
1710.4CCND1, POT1, ATM
18
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
10.4IGHG1, TP53, CCND1
19
Show member pathways
ATM Signaling Pathway37
10.4ATM, TP53, RAD51
2010.4ATM, TP53, RAD51
21
Show member pathways
10.4RAD51, TP53, ATM
2210.4RAD51, TP53, ATM
23
Show member pathways
10.4ATM, POT1, RAD51
24
Show member pathways
10.4RAD51, CCND1, TP53
25
Show member pathways
10.4CCND1, POT1, TP53, ATM
26
Show member pathways
DNA damage response37
10.4ATM, TP53, CCND1, RAD51
2710.4ATM, TP53, CCND1, RAD51
28
Show member pathways
10.4ATM, TP53, CCND1, RAD51
29
Show member pathways
10.4ATM, TP53, CCND1, RAD51
3010.4ATM, TP53, CCND1, RAD51
31
Show member pathways
10.4BTG1, CCND1, TP53, ATM
3210.4CCND1, CHST11, TP53, TNFSF13B
33
Show member pathways
10.3RAD51, CCND1, CXCR4, TP53, TNFSF13B, ATM

Compounds for genes affiliated with Chronic Lymphocytic Leukemia

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Compounds related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1aphidicolin4410.8RAD51, TP53, ATM
2melphalan44 50 1112.8TP53, CCND1, RAD51
3adpribose4410.7TP53, CCND1, CD38
4hydroxyurea44 50 1112.7RAD51, TP53, ATM
5gemcitabine44 50 1112.7RAD51, CCND1, TP53
6paclitaxel44 50 1112.7RAD51, CCND1, CXCR4, TP53
7cisplatin44 50 61 1113.7RAD51, CCND1, CXCR4, TP53, ATM
8mitomycin c4410.7RAD51, TP53, ATM
9ly2940024410.7ATM, TP53, CXCR4, CCND1
10oligonucleotide4410.7TP53, POT1, CXCR4, CCND1, RAD51
11lactacystin4410.7TP53, CXCR4, CCND1
12thymidylate4410.7RAD51, CCND1, TP53
13wortmannin4410.7ATM, CXCR4, CCND1, RAD51
14bpde4410.7ATM, TP53
15caffeine44 28 2 50 24 1115.7ATM, TP53, RAD51
16camptothecin44 61 1112.6RAD51, TP53, ATM
17chlorambucil44 1111.6RAD51, TP53
18olomoucine44 1111.6CCND1, TP53
19thymidine44 2411.5TNFSF13B, TP53, CCND1, RAD51
20imatinib44 50 1112.5CXCR4, CCND1, RAD51
21estrogen4410.4RAD51, CCND1, CXCR4, TP53, ATM
22cycloheximide4410.4RAD51, CCND1, CXCR4, TP53
23sulindac sulfide4410.3CCND1, TP53
24retinoic acid44 2411.3TP53, CXCR4, CCND1, BTG1, CD38
25o6-methylguanine4410.1TP53, RAD51

GO Terms for genes affiliated with Chronic Lymphocytic Leukemia

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Biological processes related to Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cellular response to DNA damage stimulusGO:00697410.6RAD51, CCND1, TP53, ATM
2mitotic G1 DNA damage checkpointGO:03157110.6CCND1, TP53
3double-strand break repairGO:00630210.6ATM, TP53, RAD51
4replicative senescenceGO:09039910.6TP53, ATM
5response to X-rayGO:01016510.5TP53, CCND1
6reciprocal meiotic recombinationGO:00713110.4RAD51, ATM
7response to hypoxiaGO:00166610.4CD38, CXCR4, ATM
8cellular response to ionizing radiationGO:07147910.3TP53, RAD51
9response to gamma radiationGO:01033210.1TRIM13, TP53

Products for genes affiliated with Chronic Lymphocytic Leukemia

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Sources for Chronic Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet