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CLL
MCID: CHR090

Chronic Lymphocytic Leukemia malady
12 drugs, 874 genes, 18 tissues, 820 related diseases, 29 phenotypes, 1080 articles, clinical trials.

Summaries for Chronic Lymphocytic Leukemia

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23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic lymphocytic leukemia (cll), there are too many of a specific type of white blood cell called a lymphocyte. cll is the second most common form of leukemia in adults. it often occurs during or after middle age and rarely occurs in children. usually cll does not cause any symptoms at all. if you have symptoms, they may include: painless swelling of the lymph nodes in the neck, underarm, stomach or groin feeling very tired pain or a feeling of fullness below the ribs fever and infection weight loss tests that examine the blood, bone marrow, and lymph nodes diagnose cll. your doctor may choose to just monitor you until you have symptoms. treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted immune therapy. nih: national cancer institute23

MalaCards: Chronic Lymphocytic Leukemia, also known as leukemia, lymphocytic, chronic, is related to leukemia and lymphocytic leukemia. An important gene associated with Chronic Lymphocytic Leukemia is TRIM13 (tripartite motif containing 13), and among its related pathways are Molecular Mechanisms of Cancer and p38 Signaling. The drugs chlorambucil and cyclophosphamide and the compounds calcium and oxygen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are muscle and cellular.

Wikipedia: B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most...44 more...

Aliases & Descriptions for Chronic Lymphocytic Leukemia

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6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 23MedlinePlus, 43UMLS, 32Novoseek , 24MeSH
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Aliases & Descriptions:

chronic lymphocytic leukemia 6 30 8 23 43
leukemia, lymphocytic, chronic 30
leukemia lymphocytic chronic 32
cll 30

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Related Diseases for Chronic Lymphocytic Leukemia

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13GeneCards, 14GeneDecks
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Disease types for chronic lymphocytic leukemia family:

leukemia, chronic lymphocytic 1 leukemia, chronic lymphocytic 3
leukemia, chronic lymphocytic 5 leukemia, chronic lymphocytic 4
leukemia, chronic lymphocytic 2

Diseases related to chronic lymphocytic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 812)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia167.9PIK3CD, PIM2, PIK3CA, PIK3CG, PIGU, RFX7
2lymphocytic leukemia167.9PIK3CD, PIM2, PIK3CA, PIK3CG, PIGU, RFX7
3carcinoma110.7PIK3CD, PIM2, PIK3CA, PIK3CG, PIGU, NCL
4prostatitis87.0PIK3CD, PIM2, PIK3CA, PIK3CG, NCL, PDE4A
5myeloma73.4PIM2, PIK3CA, PIK3CG, PDE4A, RECK, REL
6myeloid leukemia66.3PIK3CD, PIM2, PIK3CA, PIK3CG, NCL, RECK
7lymphoblastic leukemia62.2PIK3CA, PIK3CG, RECK, RELA, KITLG, KIR3DL1
8acute myeloid leukemia56.3PIK3CD, PIM2, PIK3CA, PIK3CG, NCL, RECK
9non-hodgkin lymphoma55.4KITLG, NBN, SELL, NAT1, NAT2, MYC
10mantle cell lymphoma54.2PIM2, PIK3CA, PIK3CG, SFRP1, RB1, SELL
11diffuse large b-cell lymphoma51.6PIK3CA, PIK3CG, PDE4A, PDE4B, REL, RELA
12acute leukemia50.7PIK3CA, NCL, KITLG, RB1, SELL, SELP
13anemia49.0RELA, REV1, KITLG, RB1, NBN, SELL
14b-cell lymphomas48.5REL, BTK, RB1, NBN, MYC, MYCN
15acute lymphoblastic leukemia47.0RECK, KITLG, KIR3DL1, BTK, RB1, NBN
16hodgkin's lymphoma46.9PIK3CG, REL, SELP, BRCA2, RAG1, BLZF1
17burkitt's lymphoma45.1MYC, MYCN, MYB, MYBL1, BMP6, RAG1
18t-cell leukemia44.7PIK3CG, REL, RELA, MYC, MYB, RAG1
19neuronitis43.8PIK3CD, PIK3CA, PIK3CG, NCL, PDE3B, PDE4A
20leukemia/lymphoma43.8PIM2, PIK3CA, PIK3CG, PDCD1LG2, REL, KITLG
21pancreatitis43.2PIK3CD, PIK3CA, PIK3CG, NCL, PDCD1LG2, PDE3B
22melanoma42.7PIK3CD, PIK3CA, PIK3CG, PIGU, NCL, PDCD1LG2
23retinoblastoma42.6PIK3CD, PIK3CA, PIK3CG, NCL, PDE3B, RECK
24immunodeficiency42.4PIK3CD, KIR3DL1, BTK, SELL, MYD88, BMP6
25ataxia42.4PIM2, PIK3CA, PIK3CG, SGCE, BYSL, NBN
26lung carcinoma41.4PIK3CA, PIK3CG, PDE4A, RELA, KITLG, RB1
27adenocarcinoma40.7PIM2, PIK3CA, PIK3CG, NCL, RECK, RELA
28arthritis40.5PIK3CD, PIK3CG, PDCD1LG2, PDE4A, RECK, REL
29b-cell non-hodgkin lymphoma40.0RB1, VEGFA, MYC, BIRC5, PAX5, BCL10
30renal cell carcinoma39.9PIK3CA, RELA, SFRP1, SELP, VIM, BRAF
31follicular lymphoma39.2REL, MYC, MYB, BIRC2, BIRC3, PAX5
32hepatocellular carcinoma39.1PIK3CD, PIM2, PIK3CA, PIK3CG, NCL, PDCD1LG2
33familial chronic lymphocytic leukemia38.5SFRP1, SFRP4, RAD51, RAD52, RAD54L, ATM
34macroglobulinemia38.5PIK3CG, KITLG, VEGFA, LPL, BLNK, BIRC3
35gastric cancer37.4PIK3CA, PIK3CG, NCL, RECK, RELA, REV3L
36myelodysplastic syndrome36.6PDE4A, KITLG, KIR3DL1, SELL, RAN, BIRC5
37hairy cell leukemia36.4BCL6, CD80, CD5, CD40, ITGA4, ITGAX
38ataxia telangiectasia36.3PIK3CA, PIK3CG, NBN, VIM, BRCA2, MYC
39multiple myeloma35.9BCL2L1, CD19, CD44, ITGA4, FGFR3, IL6
40acute lymphocytic leukemia35.9RB1, VEGFA, LPL, MYC, BIRC5, BIRC7
41richter's syndrome35.8BCR, ATM, CDKN1A, CDKN2A, CD5, CD38
42ptosis35.7LPL, BMF, BIRC2, BIRC3, BIRC5, PARP1
43waldenstrom macroglobulinemia35.3PIK3CG, KITLG, VEGFA, BLNK, BIRC3, PAX5
44thrombocytopenia35.2RECK, KITLG, SELL, SELP, MYB, BMP6
45hemolytic anemia35.0MYC, LAG3, MPO, CD59, CD40LG, CD52
46prolymphocytic leukemia34.3MYC, ZAP70, ATM, CD5, CD38, FCER2
47autoimmune hemolytic anemia34.0MYC, LAG3, MPO, CD79A, CD59, CD40LG
48t-cell prolymphocytic leukemia33.7VEGFA, CHEK2, ZAP70, MS4A1, ATM, CDKN1B
49neutropenia33.7KITLG, BTK, BLZF1, BIRC5, BCL2, LEF1
50gonococcal synovitis33.6PIK3CA, PIK3CG, PDE3B, PDE4A, RECK, REL

Graphical network of the top 20 diseases related to chronic lymphocytic leukemia:



Graphical network of diseases related to chronic lymphocytic leukemia

Clinical Features for Chronic Lymphocytic Leukemia

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Drugs & Therapeutics for Chronic Lymphocytic Leukemia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for chronic lymphocytic leukemia

Drug clinical trials:

Search ClinicalTrials for chronic lymphocytic leukemia

Search NIH Clinical Center for chronic lymphocytic leukemia

Search CenterWatch for chronic lymphocytic leukemia

Inferred drug relations via UMLS/NDF-RT:

43 28 alemtuzumab, chlorambucil, cladribine, cyclophosphamide, etoposide phosphate, fludarabine, fludarabine phosphate, globulin,immune (iv), ifosfamide, mercaptopurine, pegaspargase, uracil mustard

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for chronic lymphocytic leukemia:
Blood stem cell transplantation in Hodgkin's/non-Hodgkin's lymphoma, multiple myeloma or chronic lymphocytic leukemia patients
Embryonic/Adult Cultured Cells Related to chronic lymphocytic leukemia:
Peripheral blood/mobilized hematopoietic stem cells, PMIDs: 19015394, 17916744, 18794548

Genetic Tests for Chronic Lymphocytic Leukemia

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Anatomical Context for Chronic Lymphocytic Leukemia

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21LifeMap Discovery™, 22MalaCards
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MalaCards organs/tissues related to chronic lymphocytic leukemia:

22
Bone marrow, Whole blood, Lymph node, Spleen, Liver, Lung, Skin, Prostate, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Embryonic and adult cells/anatomical compartments related to chronic lymphocytic leukemia:
id Organ / Tissue -> Anatomical Compartment -> Cell Relevance
1 Bone -> Bone Marrow -> Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood -> Peripheral Blood -> Mature B Cells Potential therapeutic candidate, affected by disease
3 Blood -> Peripheral Blood -> Pre-B Cells Potential therapeutic candidate, affected by disease

Phenotypes for genes affiliated with Chronic Lymphocytic Leukemia

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25MGI
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MGI Mouse Phenotypes related to chronic lymphocytic leukemia:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1muscle phenotypeMP:0005369INFPIK3CA, PIK3CG, RELA, RELB, SGCE, SFRP2
2cellular phenotypeMP:000538444.9PIK3CD, PIM2, PIK3CA, PIK3CG, NCKAP1L, PDCD1LG2
3mortality/agingMP:001076839.6PIK3CA, PDCD1LG2, PDE4B, RECK, REL, RELA
4hematopoietic system phenotypeMP:000539737.8PIM2, NCKAP1L, PDCD1LG2, REV1, REV3L, SFN
5immune system phenotypeMP:000538734.9PIK3CD, PIM2, NCKAP1L, PDE4A, PDE4B, REL
6growth/size phenotypeMP:000537832.9PIM2, PIK3CA, PIK3CG, NCKAP1L, PDE3B, RECK
7nervous system phenotypeMP:000363127.2PDE4A, PDE4B, RECK, REL, RELA, REV3L
8embryogenesis phenotypeMP:000538023.6PIK3CA, RECK, REL, REV3L, SFN, SFRP1
9normal phenotypeMP:000287323.5RELA, REV1, SFRP2, SFRP5, RBL2, SEPN1
10integument phenotypeMP:001077123.5PIK3CG, PDE3B, RECK, REL, RELA, RELB
11tumorigenesisMP:000200622.4PIK3CA, PDCD1LG2, REV3L, KITLG, SFN, RCAN1
12behavior/neurological phenotypeMP:000538622.4PIK3CA, RELB, SGCE, RCAN1, RB1, NBN
13reproductive system phenotypeMP:000538920.5PIK3CA, NCKAP1L, SFN, SFRP2, SFRP4, SFRP5
14skeleton phenotypeMP:000539020.2PIK3CD, PIK3CG, RECK, REL, RELA, KITLG
15renal/urinary system phenotypeMP:000536719.7NCKAP1L, SFRP4, SELP, SELPLG, SEMA4D, BRAF
16digestive/alimentary phenotypeMP:000538119.7REL, RELB, KITLG, SFN, SFRP4, BTK
17limbs/digits/tail phenotypeMP:000537118.0RECK, RELA, RELB, KITLG, SFN, SFRP1
18craniofacial phenotypeMP:000538217.4REV3L, KITLG, NBN, BRWD3, LPAR1, LPAR4
19vision/eye phenotypeMP:000539117.3PIK3CA, RELA, KITLG, SFN, BUB1B, RB1
20respiratory system phenotypeMP:000538816.4NCKAP1L, REL, RELB, SFRP4, SELL, SELP
21hearing/vestibular/ear phenotypeMP:000537713.1KITLG, SFN, RB1, MYC, MYD88, RAG1
22other phenotypeMP:000539512.0NCKAP1L, RECK, RELB, KDR, LAMA5, MRE11A
23pigmentation phenotypeMP:000118611.9PDE3B, KITLG, RB1, BRAF, MYC, RAG1
24adipose tissue phenotypeMP:0005375INFPIK3CA, PDE3B, SFRP1, BUB1B, RB1, BRAF
25cardiovascular system phenotypeMP:0005385INFPIK3CD, PIK3CA, PIK3CG, NCKAP1L, PDE4A, PDE4B
26endocrine/exocrine gland phenotypeMP:0005379INFRELB, SFN, SFRP2, SFRP5, RCAN1, RBL2
27homeostasis/metabolism phenotypeMP:0005376INFPIK3CD, PIK3CA, PIK3CG, NCKAP1L, PDCD1LG2, PDE3B
28no phenotypic analysisMP:0003012INFPIK3CD, PDCD1LG2, SFRP1, SFRP2, RB1, RBL2
29liver/biliary system phenotypeMP:0005370INFNCKAP1L, RECK, REL, RELB, SFN, SEP15

Publications for genes affiliated with Chronic Lymphocytic Leukemia

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35PubMed
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Articles related to chronic lymphocytic leukemia:

(show top 50)    (show all 1080)
idTitleAuthorsYearAffiliating Genes
1Polymorphisms and haplotypes in multidrug resistance 1 gene are not associated with chronic lymphocytic leukemia susceptibility and prognostic parameters of chronic lymphocytic leukemia in Chinese population. (21463115)Dong H.J.... Li J.Y.2011ZAP70, TP53, ABCB1
2CD5 promotes IL-10 production in chronic lymphocytic leukemia B cells through STAT3 and NFAT2 activation. (21398617)Garaud S.... Youinou P.2011STAT3, CD5, IL10
3Involvement of RhoH GTPase in the development of B-ce ll chronic lymphocytic leukemia. (19847197)Sanchez-Aguilera A.... Williams D.A.2010ZAP70, RHOH
4Impaired expression of p66Shc, a novel regulator of B -cell survival, in chronic lymphocytic leukemia. (20061561)Capitani N.... Baldari C.T.2010SHC1, IGHV@
5Differential genome-wide array-based methylation prof iles in prognostic subsets of chronic lymphocytic leukemia. (19897574)Kanduri M.... Rosenquist R.2010VHL, PRF1, CADM1
6Activation-induced cytidine deaminase splicing patter ns in chronic lymphocytic leukemia. (20117026)Marantidou F.... Patsouris E.2010AICDA
7Chromosome study on chronic lymphocytic leukemia usi ng CpG-oligodeoxynucleotide as immunostimulant agent (20140876)Wu Y.... Bai S.2010IGH@
8Stereotyped B-cell receptor is an independent risk fa ctor of chronic lymphocytic leukemia transformation to Richter syndrome. (19509140)Rossi D.... Gaidano G.2009BCR
9Subcutaneous alemtuzumab in fludarabine-refractory ch ronic lymphocytic leukemia: clinical results and prognostic marker analyses fro m the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. (19597025)Stilgenbauer S.... DAPhner H.2009TP53, TKT
10Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study . (19828698)Tsai H.T.... Landgren O.2009MYOM2
11PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. (19168795)Holler C.... Egle A.2009BCR, PRKCB, TCL1A
12Monoallelic and biallelic inactivation of TP53 gene i n chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage. (19850740)Malcikova J.... Trbusek M.2009TP53
13Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. (19008458)Vogler M.... Cohen G.M.2009BCL2L1
14ZAP-70 protein expression and CD38 positivity in B-cell chronic lymphocytic leukemia. (18322442)Ertault-Daneshpouy M.... Mounier N.2008ZAP70, CD38
154-arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients. (18922614)Billard C.... Kolb J.P.2008CDKN1B
16Characterising the TP53-deleted subgroup of chronic lymphocytic leukemia: an analysis of additional cytogenetic abnormalities detected by interphase fluorescence in situ hybridisation and array-based comparative genomic hybridisation. (18949611)Rudenko H.C.... Morgan G.J.2008TP53
17Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation. (18474259)Hammadi A.... Kolb J.P.2008NFKB1, NOS2, TLR7
18Immunophenotypic features distinguishing familial chronic lymphocytic leukemia from sporadic chronic lymphocytic leukemia. (18431797)Ahmad E.... Stetler-Stevenson M.2008ANPEP, CD2, CD38
19CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? (18424664)Aydin S.... Deaglio S.2008CD38
20The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. (18227347)Hewamana S.... Pepper C.2008RELA
21Combined molecular biological and molecular cytogenetic analysis of genomic changes in 146 patients with B-cell chronic lymphocytic leukemia. (18665750)Berkova A.... Michalova K.2008ATM
22Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells. (17151701)Iglesias-Serret D.... Pons G.2007BCL2L11
23The soluble transferrin receptor reflects tumor load in chronic lymphocytic leukemia. (17727315)Metzgeroth G.... Hastka J.2007TFRC
24Translocations as a mechanism for homozygous deletion of 13q14 and loss of the ATM gene in a patient with B-cell chronic lymphocytic leukemia. (17350468)Herholz H.... Haferlach C.2007ATM
25In vitro sensitivity of B-cell chronic lymphocytic leukemia to cladribine and its combinations with mafosfamide and/or mitoxantrone. (17089066)Kobylinska A.... Kilianska Z.M.2006BCL2, CASP3, PARP1
26CLLU1 expression levels predict time to initiation of therapy and overall survival in chronic lymphocytic leukemia. (16529606)Buhl A.M.... Leffers H.2006ZAP70, CD38, CLLU1
27Germline mutations in Dok1 do not predispose to chronic lymphocytic leukemia. (15541476)Sellick G.S.... Houlston R.S.2005DOK1
28Expression of adhesion molecules on leukemic B cells from chronic lymphocytic leukemia patients with predominantly splenic manifestations. (15055269)Bairey O.... Shaklai M.2004ITGAX
29Serum angiogenin is not elevated in patients with early B-cell chronic lymphocytic leukemia but is prognostic factor for disease progression. (15182336)Molica S.... Digiesi G.2004ANG
30TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. (15545599)Zapata J.M.... Reed J.C.2004BCL2, TRAF2, TRAF1
31Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia. (12592341)Fulop Z.... Matolcsy A.2003MLH1
32Some genomic aberrations in B-cell chronic lymphocytic leukemia and their clinical relevance. Part II. Trisomy 12 in B-cell chronic lymphocytic leukemia detected by fluorescence in situ hybridization (15052938)Wasik-Szczepanek E.... Bojarska A.2003TP53, IGHV@
33Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation. (12521993)Oppezzo P.... Dighiero G.2003AICDA
34CD5-negative, CD10-negative small B-cell leukemia: variant of chronic lymphocytic leukemia or a distinct entity? (12447961)Sheikh S.S.... Bagg A.2002MME, CD5
35Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia. (12010815)Mertens D.... Lichter P.2002SPRYD7
36Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. (12011454)Bichi R.... Croce C.M.2002TCL1A
37p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. (11468183)Pettitt A.R.... Stankovic T.2001TP53, ATM
38Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D. (11753607)Olsson A.... Osorio L.M.2001BCL2, TNFSF10, TNFRSF10C
39Gemcitabine demonstrates in vitro activity against human B-cell chronic lymphocytic leukemia. (11337014)Waselenko J.K.... Byrd J.C.2001TP53, BCL2, BAX
40Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes. (10803511)Capello D.... Ferrarini M.2000BCL6
41Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells. (10666220)Nilsson J.... Rosen A.2000IL2, IL4, TXN
42Role of beta2 integrins in the prevention of apoptosis induction in chronic lymphocytic leukemia B cells. (10637474)Plate J.M.... Kelkar S.B.2000ICAM1
43Simultaneous detection of BCL-2 protein, trisomy 12, retinoblastoma and P53 monoallelic gene deletions in B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (FISH): relation to disease status. (10784395)Lazaridou A.... Christakis J.I.2000BCL2
44Effects of cytokines on CD20 antigen expression on tumor cells from patients with chronic lymphocytic leukemia. (10785263)Venugopal P.... Preisler H.D.2000TNF, IL2, KITLG
45Sensorimotor polyneuropathy associated with chronic lymphocytic leukemia, IgM antigangliosides antibody and human T-cell leukemia virus I infection. (10487916)Mitsui Y.... Takahashi M.1999CD40LG
46Proliferative response of B chronic lymphocytic leukemia lymphocytes stimulated with IL2 and soluble CD23. (7950920)Brizard A.... Preud'homme J.L.1994IL2, IL4, FCER2
47Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors. (1281692)Fluckiger A.C.... Defrance T.1992CD40
48Recombinant alpha-2b-interferon may restore natural-k iller activity in patients with B-chronic lymphocytic leukemia. (1376376)Villamor N.... Rozman C.1992IFNA2
49A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia. (2069907)Rimokh R.... Samarut J.1991BTG1
50Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia. (2113601)Gignac S.M.... Drexler H.G.1990DYT10

Expression for genes affiliated with Chronic Lymphocytic Leukemia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Chronic Lymphocytic Leukemia

Pathways for genes affiliated with Chronic Lymphocytic Leukemia

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36QIAGEN, 20KEGG, 38Reactome, 41Thomson Reuters, 10EMD Millipore, 37R&D Systems, 3Cell Signaling Technology, 34PharmGKB
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Pathways related to chronic lymphocytic leukemia according to GeneDecks:

(show top 50)    (show all 414)
idPathwayScoreTop Affiliating Genes
1Molecular Mechanisms of Cancer3620.3PIK3CG, KITLG, BTK, RB1, MYC, BMP6
2p38 Signaling3619.6KITLG, BTK, BMP6, KDR, BCL2, ZAP70
3Cytokine-cytokine receptor interaction2017.2KITLG, VEGFA, KDR, XCL1, CD27, CD70
4Immune System3815.4PDCD1LG2, REL, KIR3DL1, VCAM1, RAP1GAP, LILRB2
5Regulation of eIF4 and p70S6K3615.2BTK, BAX, CD2, CD4, CD80, ITGA3
6NF-KappaB Family Pathway3614.8REL, RELA, RELB, KITLG, VAV3, MYD88
7MIF Regulation of Innate Immune Cells3613.9BTK, BMP6, BCL2, BAX, CD2, CD14
8Small cell lung cancer2013.8PIK3CD, PIK3CA, PIK3CG, RELA, RB1, MYC
9p53 Signaling3613.6SFN, BCL2, CHEK2, BAX, ATR, ATM
10DHA Signaling3613.6KITLG, BMP6, BID, BIK, KDR, BCL2
11Immune response_IL-4 signaling pathway4113.5PIK3CD, PIK3CA, REL, RELA, RELB, RAF1
12Apoptosis and survival Lymphotoxin-beta receptor signaling1013.1RELA, RELB, VCAM1, BIRC2, CHUK, BAX
13NFAT in Immune Response3613.1KITLG, BTK, BMP6, BLNK, KDR, CHUK
14DNA damage_ATM/ATR regulation of G1/S checkpoint4112.7REL, RELA, RELB, NBN, MYC, CHEK2
15Development Angiopoietin - Tie2 signaling1012.7PIK3CD, PIK3CA, REL, RELA, RELB, BIRC5
16CREB Pathway3612.6KITLG, BMP6, KDR, FLT4, FGF1, FGF10
17Ras Pathway3612.6BRAF, RAF1, KDR, LCK, AXL, ITGA3
18Development PDGF signaling via STATs and NF-kB1012.5PIK3CD, PIK3CA, REL, RELA, RELB, MYC
19TRAIL Pathway3612.5BID, CHUK, CFLAR, APAF1, FADD, IKBKB
20TNF Signaling3612.5BID, BIRC2, BIRC3, CHUK, ATF6, APAF1
21Activation of PKA through GPCR3612.5PDE3B, KITLG, BRAF, BMP6, RAF1, KDR
22Development_IGF-1 receptor signaling4112.4PIK3CD, PIK3CA, REL, RELA, RELB, MYC
23Apoptosis and survival_Caspase cascade4112.4BID, PARP1, BAX, XIAP, APAF1, FASLG
24Toll-Like Receptor Signaling Pathways3712.4RELA, RELB, MYD88, CHUK, CD36, CD14
25Chronic myeloid leukemia2012.3PIK3CD, PIK3CA, PIK3CG, RELA, RB1, BRAF
26TNFR1 Pathway3612.2BID, BIRC2, BIRC3, CHUK, APAF1, FADD
27Renin-Angiotensin Pathway3612.2KITLG, VCAM1, BMP6, RAF1, KDR, CHUK
28Immune response IL-9 signaling pathway1012.1PIK3CD, RELA, RAF1, BCL3, JAK1, GRB2
29Tyrosine Kinases / Adaptors312.1KITLG, BTK, BLNK, KDR, BCR, ZAP70
30Colorectal Cancer Metastasis3612.0BRAF, MYC, BIRC5, BCL2L1, LEF1, BAX
31Inflammasome Activation Pathways3711.9RELA, RELB, MYD88, CHUK, P2RX7, IL18
32Development_Prolactin receptor signaling4111.8PIK3CD, PIK3CA, RELA, MYC, RAF1, BCL2
33Translation Non-genomic (rapid) action of Androgen Receptor1011.8REL, RELA, RELB, RAF1, FOXO3, GRB2
34Acute myeloid leukemia2011.8PIK3CD, PIM2, PIK3CA, PIK3CG, BRAF, MYC
35Development Thrombopoietin-regulated cell processes1011.8PIK3CD, PIK3CA, BRAF, MYC, RAF1, BIRC5
36Immune response IL-10 signaling pathway1011.7PIK3CD, PIK3CA, BCL2, BCL2L1, JAK1, CD14
37Immune response IL-22 signaling pathway1011.7MYC, BCL2, BCL2L1, JAK1, JAK2, CD28
38Immune response_NFAT in immune response4111.7PIK3CD, RELB, CD28, IKBKB, IGLV@, IGHJ@
39Immune response_IL-22 signaling pathway4111.7MYC, BCL2, BCL2L1, JAK1, JAK2, CD28
40Chagas disease (American trypanosomiasis)2011.6PIK3CD, PIK3CA, PIK3CG, RELA, MYD88, CHUK
41Translation Regulation activity of EIF4F1011.5PIK3CD, MAP2K3, AKT2, AKT3, PDPK1, RHEB
42Apoptosis and survival Role of CDK5 in neuronal death and survival1011.4BCL2, BAD, APAF1, CASP9, AKT3, CYCS
43Allograft rejection2011.3CD28, CD86, CD40LG, CD80, CD40, GZMB
44Signal transduction_PTEN pathway4111.3ITGB1, IGF1R, CASP9, PDPK1, RHEB, TSC2
45Angiogenesis311.2RECK, SERPINB5, VHL, KDR, ITGAV, ITGB1
46Development_EGFR signaling pathway4111.1PIK3CD, PIK3CA, REL, RELB, MYC, RAF1
47Immune response IL-1 signaling pathway1011.1RELA, MYD88, CHUK, UBE2N, IRAK4, IL1A
48EGFR Inhibitor Pathway, Pharmacodynamics3410.9PLCG2, KRAS, STAT5A
49Malaria2010.4SELP, VCAM1, MYD88, SDC1, CD36, CD81
50ErbB signaling pathway2010.4PIK3CD, PIK3CA, PIK3CG, BRAF, MYC, RAF1

Compounds for genes affiliated with Chronic Lymphocytic Leukemia

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to chronic lymphocytic leukemia according to GeneDecks:

(show top 50)    (show all 405)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 33.6PIK3CD, NCL, PDE3B, PDE4A, RECK, REL
2oxygen32 18 23.9KITLG, RB1, SELPLG, VDAC1, MYB, RAN
3atp32 22.0PIK3CA, NCL, PDE3B, PDE4A, RECK, KIR3DL1
4nitric oxide32 9 18 9 21.8PDE3B, PDE4A, REL, KITLG, RB1, SELP
5superoxide32 18 18.4PIK3CA, PDE3B, PDE4A, KITLG, SFN, RB1
6adp32 18 18.2PIK3CD, PIM2, PIK3CA, PIK3CG, RECK, BUB1B
7cholesterol32 9 18 9 19.9PIK3CA, PDE3B, RECK, KITLG, RB1, SELP
8cysteine32 16.9RECK, REL, BTK, SELP, SELPLG, NAT1
9camptothecin32 42 9 9 19.0PIK3CG, NCL, RB1, NBN, BRCA2, MYC
10cytarabine32 34 9 9 17.7KITLG, RB1, VIM, MYC, BCL2, BCL2L1
112-chlorodeoxyadenosine32 14.1BIRC5, PARP1, BCL2, BAX, XIAP, B2M
12ceramide32 13.9PIK3CA, PDE3B, RB1, RAF1, BID, BCL2L1
13lactate32 13.7PIK3CA, RECK, KITLG, SELL, SELP, VIM
14mg 13232 42 14.4PIK3CG, MYC, MYCN, BLZF1, BID, BIK
15estradiol32 9 18 9 16.1KITLG, RB1, VIM, BRCA2, MYB, BIRC5
16noxa32 13.0BID, BIRC5, BCL2, BCL2L1, BCL2L11, BBC3
17n acetylcysteine32 12.9SELP, VCAM1, RAF1, BIRC5, KDR, CHEK2
18calcitriol32 42 9 18 9 16.9KITLG, SFRP4, RB1, MYC, BMP6, PAX5
19phenylalanine32 12.7BTK, SELPLG, BLZF1, BCR, ZAP70, LCK
20matrigel32 12.7PIK3CA, PIK3CG, RB1, SERPINB5, VIM, BRAF
21heparan sulfate32 18 13.7NCL, VIM, LPL, BMP6, KDR, SDC1
22thalidomide32 42 9 9 15.3PDE4A, SELL, VEGFA, BIRC2, BIRC3, BIRC5
23melphalan32 9 9 14.3RAD51, BIRC5, BCL2L1, BCL2L11, XRCC3, XRCC5
24methylmethanesulfonate32 12.2NBN, BRCA2, RAD51, RAD52, RAD50, PARP1
25nadph32 18 13.1PIK3CA, MYD88, XRCC1, XPC, P4HB, GMPR2
26roscovitine32 12.1PIK3CG, VIM, BIRC5, PARP1, BCL2L1, XIAP
27celecoxib32 42 34 9 18 9 16.9PIK3CG, VEGFA, BIRC5, PARP1, KDR, BCL2
28hoechst 3334232 11.8NCL, KITLG, BIRC5, PARP1, BCL2, BAX
29carboplatin32 34 9 9 14.8KITLG, RB1, VEGFA, BID, PARP1, KDR
30rottlerin32 42 12.8PIK3CG, VCAM1, PARP1, XIAP, CDK6, CD36
31p00232 11.7RB1, SERPINB5, BRAF, BRCA2, BIRC5, MTHFR
32p00332 11.7RB1, BRCA2, MTRR, XRCC3, CDKN1B, CD14
33nocodazole32 42 9 9 14.7NCL, BUB1B, VIM, RAF1, RAN, BIRC5
34leukotriene b432 42 18 13.7PDE4A, SELL, SELP, MPO, ITGAL, ITGAM
35vinblastine32 9 9 13.6BUB1B, VIM, RAF1, BIRC5, KDR, BCL2
36rotenone32 11.5PIK3CG, PARP1, BCL2, BCL2L1, BAD, GSR
37agar32 11.4PIK3CA, KITLG, RB1, VIM, BRAF, VDAC1
38herbimycin a32 42 12.3PIK3CG, KITLG, SELL, VCAM1, MYC, BMP6
39simvastatin32 34 42 9 18 9 16.3KITLG, SELL, SELP, VEGFA, LPL, VCAM1
40norepinephrine32 9 18 9 14.0PDE4A, KITLG, SELL, SELP, LPL, VCAM1
41rosiglitazone32 9 18 9 13.9PIK3CA, PIK3CG, LPL, VCAM1, JAK2, CDKN1A
42infliximab32 9 9 12.9VEGFA, BAK1, ITGA4, MMP1, MMP3, FGF2
43poly(i-c)32 10.8VCAM1, CHUK, MX1, CD69, IL15, IL18
44atorvastatin32 34 9 18 9 14.6SELL, SELP, VEGFA, LPL, VCAM1, BMP6
45il 1032 10.6BMP6, CD8A, CD40, IL10, IL10RA, IL13
46suramin32 9 9 12.5RECK, VEGFA, BMP6, RAF1, KDR, P2RX7
47polyethylene glycol32 10.5KITLG, VDAC1, P4HB, MPO, CDH1, APOE
48acetylcholine32 9 18 9 13.5PDE4A, VIM, LPL, BMP6, RAF1, BLZF1
49sulfasalazine32 9 9 12.2NAT2, CHUK, MTHFR, MPO, CD79A, CD40LG
50p0000132 10.0BRAF, BIRC5, MTHFR, CDKN1B, CD14, CDKN2A

GO Terms for genes affiliated with Chronic Lymphocytic Leukemia

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Sources:
12Gene Ontology
See all sources

Cellular components related to chronic lymphocytic leukemia according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1nucleusGO:005634INFRFX7, NCL, PDE4A, PDE4B, RELA, RELB
2plasma membraneGO:00588632.3PIK3CD, PIK3CG, PIGU, PDCD1LG2, RECK, KITLG
3cytosolGO:00582927.0PIK3CD, PIK3CA, PIK3CG, NCKAP1L, PDE3B, PDE4A
4integral to plasma membraneGO:00588721.7NCKAP1L, SGCE, KIR3DL1, SELL, SELP, SELPLG
5nucleoplasmGO:00565420.4REL, RELA, REV1, RB1, RBL2, NBN
6extracellular regionGO:00557618.4PDCD1LG2, KITLG, SEMG1, SEPN1, VEGFA, LPL
7external side of plasma membraneGO:00989716.3SELL, SELP, VCAM1, KDR, SCNN1A, LAG3
8membraneGO:01602014.6PIK3CG, NCKAP1L, PDE3B, PDE4A, RECK, GCC2
9cell surfaceGO:00998613.4SFRP1, SFRP4, VEGFA, LPAR1, LPAR2, LPL
10membrane raftGO:04512110.9BTK, BCL10, LCK, P2RX7, JAK2, CD79A
11cytoplasmGO:005737INFPIK3CG, RELA, SGCE, KITLG, SFN, SFRP4
12extracellular spaceGO:005615INFKITLG, SFN, SFRP1, SFRP2, SFRP4, SFRP5

Biological processes related to chronic lymphocytic leukemia according to GeneDecks:

(show top 50)    (show all 95)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:045944INFRELA, SFRP2, RB1, VEGFA, MYC, MYCN
2signal transductionGO:00716522.3PIK3CD, PDE4A, PDE4B, KITLG, SFN, SFRP5
3apoptotic processGO:00691520.2SFN, SFRP5, BUB1B, BTK, NBN, VIM
4immune responseGO:00695519.3PDCD1LG2, KIR3DL1, SEMA4D, BMP6, RAG1, LILRB2
5innate immune responseGO:04508716.6PIK3CD, PIK3CG, RELA, BTK, MYD88, BCL10
6cell-cell signalingGO:00726715.7SFRP2, LILRB2, XCL1, CD33, CD70, CD86
7DNA repairGO:00628115.3REV1, NBN, BRCA2, RAD51, RAD52, RAD50
8positive regulation of transcription, DNA-dependentGO:04589315.0PIM2, REL, RELA, SFRP1, RB1, BRCA2
9inflammatory responseGO:00695414.9PIK3CD, PIK3CG, RELA, SELP, MYD88, BMP6
10negative regulation of apoptotic processGO:04306614.8PIK3CG, NCKAP1L, RELA, SFRP1, BRAF, VEGFA
11virus-host interactionGO:01904814.5RELA, RB1, VIM, VDAC1, VCAM1, RAN
12induction of apoptosisGO:00691714.4BIK, BCL10, BCL2L11, MX1, BBC3, LCK
13positive regulation of cell proliferationGO:00828414.2SFRP1, SFRP2, NBN, VEGFA, MYC, BIRC5
14anti-apoptosisGO:00691614.0PIM2, PIK3CA, RELA, SEMA4D, BRAF, VHL
15regulation of immune responseGO:05077613.8KIR3DL1, SELL, VCAM1, LILRB2, BCL6, ULBP1
16negative regulation of cell proliferationGO:00828513.8PIM2, SFN, SFRP1, SFRP2, SFRP4, SFRP5
17blood coagulationGO:00759613.6PIK3CA, PIK3CG, PDE3B, SELL, SELP, SELPLG
18induction of apoptosis by extracellular signalsGO:00862413.6BTK, VAV3, BCL2L11, BAD, BAK1, BAX
19activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691913.4MYC, BCL2L11, BBC3, LCK, BAD, BAX
20positive regulation of apoptotic processGO:04306513.4SFRP1, SFRP2, SFRP4, LPAR1, BID, BCL2L11
21insulin receptor signaling pathwayGO:00828613.1PIK3CA, PDE3B, RAF1, MTOR, FRS2, CDK1
22cell surface receptor signaling pathwayGO:00716613.1MYD88, LILRB2, BIRC2, BIRC3, BAG1, LAG3
23leukocyte migrationGO:05090013.0PIK3CA, SELL, SELP, SELPLG, LCK, CD58
24cell cycle arrestGO:00705012.9BTG4, RB1, RBM38, NBN, MYC, MSH2
25toll-like receptor signaling pathwayGO:00222412.9RELA, BTK, MYD88, BCL10, CHUK, UBE2N
26response to drugGO:04249312.9NCKAP1L, PDE4A, SFRP1, SFRP2, NBN, LPL
27Toll signaling pathwayGO:00806312.9RELA, BTK, MYD88, CHUK, UBE2N, CD14
28induction of apoptosis by intracellular signalsGO:00862912.9MYC, BMF, BID, BCL2, BCL2L1, BCL2L11
29toll-like receptor 4 signaling pathwayGO:03414212.8RELA, BTK, MYD88, CHUK, UBE2N, CD14
30T cell costimulationGO:03129512.8PIK3CA, PDCD1LG2, LCK, MTOR, CD28, CD86
31positive regulation of B cell proliferationGO:03089012.8NCKAP1L, VAV3, BCL2, BCL6, CDKN1A, CD40LG
32activation of MAPK activityGO:00018712.7LPAR1, LPAR2, LPAR3, P2RX7, FRS2, CD81
33cytokine-mediated signaling pathwayGO:01922112.5RELA, VCAM1, MYD88, MX1, UBE2N, BAD
34MyD88-dependent toll-like receptor signaling pathwayGO:00275512.4RELA, BTK, MYD88, CHUK, UBE2N, CDK1
35positive regulation of NF-kappaB transcription factor activityGO:05109212.4RELA, BTK, MYD88, BCL10, CHUK, UBE2N
36toll-like receptor 3 signaling pathwayGO:03413812.4RELA, CHUK, CD14, CDK1, IRAK2, MAPK8
37TRIF-dependent toll-like receptor signaling pathwayGO:03566612.3RELA, CHUK, CD14, CDK1, IRAK2, MAPK8
38MyD88-independent toll-like receptor signaling pathwayGO:00275612.3RELA, CHUK, CDK1, IRAK2, MAPK8, MAP3K7
39toll-like receptor 1 signaling pathwayGO:03413012.3RELA, BTK, MYD88, CHUK, UBE2N, CDK1
40toll-like receptor 2 signaling pathwayGO:03413412.3RELA, BTK, MYD88, CHUK, UBE2N, CDK1
41fibroblast growth factor receptor signaling pathwayGO:00854312.3PIK3CA, BRAF, RAF1, CHUK, BAD, MTOR
42cellular response to mechanical stimulusGO:07126012.1MYD88, BCL10, BAD, BAK1, CD40, ITGB1
43response to gamma radiationGO:01033212.0BRCA2, MYC, LIG4, BCL2, CHEK2, BAK1
44nerve growth factor receptor signaling pathwayGO:04801112.0PIK3CA, RELA, BRAF, VAV3, MYD88, RAF1
45positive regulation of T cell proliferationGO:04210211.9NCKAP1L, PDCD1LG2, VCAM1, LILRB2, CD28, CD1D
46response to hypoxiaGO:00166611.9VEGFA, VCAM1, RAF1, BCL2, XRCC1, ATM
47positive regulation of ERK1 and ERK2 cascadeGO:07037411.8BRAF, KDR, CD74, CD44, FLT4, MIF
48positive regulation of tumor necrosis factor productionGO:03276011.5MYD88, JAK2, CD36, CD14, IL18, FADD
49positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.3KITLG, SEMA4D, VEGFA, MTOR, JAK2, CD36
50platelet activationGO:03016811.2PIK3CA, PIK3CG, SELP, VEGFA, VAV3, RAF1

Molecular functions related to chronic lymphocytic leukemia according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:005515INFPIK3CD, PIK3CA, PIK3CG, NCKAP1L, NCL, PDE3B
2ATP bindingGO:00552418.5PIK3CD, PIM2, PIK3CA, PIK3CG, BUB1B, BTK
3receptor activityGO:00487214.6SEMA4D, LILRB4, LILRB2, CD33, CD2, CD86
4protein homodimerization activityGO:04280314.5VEGFA, RAG1, RAP1GAP, BIRC5, BCL11A, BCL2
5receptor bindingGO:00510214.0SELPLG, SEMA4D, LPL, P2RX7, JAK2, CD70
6protein kinase bindingGO:01990113.9RELA, VIM, BCL10, BCL2L1, CHEK2, LCK
7identical protein bindingGO:04280213.8RELA, SFRP1, GCC2, BTK, VIM, MYD88
8protein heterodimerization activityGO:04698213.2BRAF, VEGFA, MYC, BMP6, RAF1, BIK
9cytokine activityGO:00512512.5KITLG, VEGFA, BMP6, CD70, CD40LG, MIF
10tumor necrosis factor receptor bindingGO:00516412.3CD70, CD40LG, FASLG, FADD, CASP8, TRAF2
11transmembrane signaling receptor activityGO:00488812.2SEMA4D, LAG3, CD79A, CD27, CD69, CD79B
12protein kinase activityGO:00467212.0PIK3CG, BUB1B, BRAF, RAF1, CHUK, AURKA
13growth factor activityGO:00808311.8KITLG, VEGFA, BMP6, JAG2, FGF1, FGF10
14enzyme bindingGO:01989911.6BTG1, VHL, BLZF1, BIRC5, BIRC7, BCL10

Sources for Chronic Lymphocytic Leukemia

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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