MCID: CHR064
MIFTS: 34

Chronic Monocytic Leukemia

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Chronic Monocytic Leukemia

MalaCards integrated aliases for Chronic Monocytic Leukemia:

Name: Chronic Monocytic Leukemia 12 14
Leukemia, Monocytic, Chronic 69
Leukemia, Myeloid 41

Classifications:



External Ids:

Disease Ontology 12 DOID:8593
ICD10 32 C93.1
ICD9CM 34 206.1
MeSH 41 D007951
NCIt 46 C34774
UMLS 69 C0023466

Summaries for Chronic Monocytic Leukemia

MalaCards based summary : Chronic Monocytic Leukemia, also known as leukemia, monocytic, chronic, is related to leukemia, acute myeloid and myeloid leukemia. An important gene associated with Chronic Monocytic Leukemia is C3 (Complement C3), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and Focal Adhesion. Affiliated tissues include monocytes and myeloid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chronic Monocytic Leukemia

Diseases in the Monocytic Leukemia family:

Leukemia, Acute Monocytic Adult Acute Monocytic Leukemia
Chronic Monocytic Leukemia Subacute Monocytic Leukemia

Diseases related to Chronic Monocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 30.7 CD34 ITGAM ITGAX MPO PTPRC
2 myeloid leukemia 11.7
3 leukemia, chronic myeloid 11.1
4 atypical chronic myeloid leukemia 11.1
5 hypersensitivity vasculitis 10.4 C3 MPO
6 hypersensitivity reaction type iii disease 10.3 C3 MPO
7 granulocytopenia 10.3 ITGAM MPO
8 periodontosis 10.3 ITGAM MPO
9 henoch-schoenlein purpura 10.3 C3 MPO
10 retina lymphoma 10.3 CD34 MPO
11 endometrial small cell carcinoma 10.2 F2 PTPRC
12 extracutaneous mastocytoma 10.2 CD34 PTPRC
13 liver inflammatory pseudotumor 10.2 CD34 PTPRC
14 glomeruloid hemangioma 10.2 CD34 PTPRC
15 spleen angiosarcoma 10.2 CD34 PTEN
16 extraosseous osteosarcoma 10.2 CD34 PTPRC
17 melanotic neurilemmoma 10.2 CD34 PTEN
18 diffuse cutaneous mastocytosis 10.2 CD34 PTPRC
19 sarcomatoid squamous cell skin carcinoma 10.2 CD34 PTPRC
20 vulvar sarcoma 10.2 CD34 PTPRC
21 dendritic cell tumor 10.2 MPO PTPRC
22 conventional fibrosarcoma 10.2 CD34 PTPRC
23 hemangioma of liver 10.2 CD34 F2
24 myeloid sarcoma 10.1 MPO PTPRC
25 chronic maxillary sinusitis 10.1 C3 MPO
26 aleukemic leukemia cutis 10.1 CD34 MPO
27 ascending cholangitis 10.1 C3 F2 MPO
28 eccrine adenocarcinoma 10.1 CD34 F2
29 leukemia 10.1
30 monocytic leukemia 10.1
31 essential thrombocythemia 10.1 F2 ITGAM MPO
32 reticulohistiocytic granuloma 10.1 CD34 PTPRC
33 lymphocytic vasculitis 10.0 ITGAM ITGAX
34 arteritic anterior ischemic optic neuropathy 10.0 F2 MPO
35 gastrointestinal system cancer 9.9 CD34 F2 PTEN
36 venous insufficiency 9.8 F2 ITGAM
37 acute promyelocytic leukemia 9.8 CD34 ITGAM MPO PTPRC
38 myocardial infarction 9.6 CD34 F2 ITGAM MPO
39 lymphoma, non-hodgkin, familial 9.5 CD34 ITGAX PTPRC

Graphical network of the top 20 diseases related to Chronic Monocytic Leukemia:



Diseases related to Chronic Monocytic Leukemia

Symptoms & Phenotypes for Chronic Monocytic Leukemia

GenomeRNAi Phenotypes related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 PTPRC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.44 ITGAM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.44 ITGAM
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.44 PTPRC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.44 PTPRC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.44 PTPRC
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.44 PTEN
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 PTPRC
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.44 F2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.44 F2 ITGAM PTEN PTPRC

MGI Mouse Phenotypes related to Chronic Monocytic Leukemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 ITGAX MPO PTEN PTPRC C3 CD34
2 homeostasis/metabolism MP:0005376 9.61 ITGAM LGALS1 MPO PTEN PTPRC C3
3 immune system MP:0005387 9.32 ITGAX LGALS1 MPO PTEN PTPRC C3

Drugs & Therapeutics for Chronic Monocytic Leukemia

Search Clinical Trials , NIH Clinical Center for Chronic Monocytic Leukemia

Cochrane evidence based reviews: leukemia, myeloid

Genetic Tests for Chronic Monocytic Leukemia

Anatomical Context for Chronic Monocytic Leukemia

MalaCards organs/tissues related to Chronic Monocytic Leukemia:

38
Monocytes, Myeloid

Publications for Chronic Monocytic Leukemia

Articles related to Chronic Monocytic Leukemia:

# Title Authors Year
1
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia. ( 23995854 )
2013
2
BCR-ABL translocation in a dog with chronic monocytic leukemia. ( 21143615 )
2011
3
Chronic monocytic leukemia terminating in blastic transformation. ( 3465380 )
1986
4
Chronic monocytic leukemia in adults. ( 6945897 )
1981
5
Chronic monocytic leukemia. ( 276262 )
1978
6
Chronic monocytic leukemia: a case with an eight-year survival. ( 5240097 )
1967
7
Chronic monocytic leukemia in childhood. ( 13576375 )
1958

Variations for Chronic Monocytic Leukemia

Expression for Chronic Monocytic Leukemia

Search GEO for disease gene expression data for Chronic Monocytic Leukemia.

Pathways for Chronic Monocytic Leukemia

Pathways related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 ITGAD ITGAM ITGAX PTEN
2
Show member pathways
12.65 ITGAD ITGAM ITGAX PTEN
3 12.34 F2 ITGAD ITGAM ITGAX
4 12.27 CD34 LGALS1 MPO PTPRC
5
Show member pathways
12.18 ITGAD ITGAM ITGAX
6
Show member pathways
12 F2 ITGAM ITGAX
7 12 C3 ITGAM ITGAX
8
Show member pathways
11.96 F2 ITGAD ITGAM ITGAX
9 11.91 C3 ITGAM MPO
10
Show member pathways
11.89 ITGAD ITGAM ITGAX
11
Show member pathways
11.89 ITGAD ITGAM ITGAX PTEN
12 11.85 CD34 ITGAM PTPRC
13
Show member pathways
11.8 C3 ITGAM ITGAX
14 11.7 ITGAD ITGAM ITGAX
15 11.7 C3 F2 ITGAM ITGAX
16 11.59 CD34 ITGAM PTPRC
17 11.45 CD34 ITGAM PTPRC
18 11.39 C3 ITGAD ITGAM ITGAX
19 11.25 ITGAD ITGAM ITGAX
20 11.13 CD34 ITGAM ITGAX PTPRC
21 11.09 CD34 ITGAM ITGAX MPO PTPRC

GO Terms for Chronic Monocytic Leukemia

Cellular components related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 CD34 ITGAD ITGAM ITGAX LGALS1 PTPRC
2 integrin complex GO:0008305 9.33 ITGAD ITGAM ITGAX
3 external side of plasma membrane GO:0009897 9.02 CD34 F2 ITGAM ITGAX PTPRC

Biological processes related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.73 CD34 ITGAD ITGAM ITGAX
2 cellular protein metabolic process GO:0044267 9.58 C3 F2 LGALS1
3 extracellular matrix organization GO:0030198 9.54 ITGAD ITGAM ITGAX
4 integrin-mediated signaling pathway GO:0007229 9.33 ITGAD ITGAM ITGAX
5 heterotypic cell-cell adhesion GO:0034113 9.32 ITGAD ITGAX
6 amyloid-beta clearance GO:0097242 9.26 C3 ITGAM
7 leukocyte migration GO:0050900 9.26 CD34 F2 ITGAM ITGAX
8 neutrophil degranulation GO:0043312 9.02 C3 ITGAM ITGAX MPO PTPRC

Sources for Chronic Monocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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