MCID: CHR063
MIFTS: 63

Chronic Mucocutaneous Candidiasis malady

Rare diseases, Skin diseases, Blood diseases categories

Summaries for Chronic Mucocutaneous Candidiasis

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Disease Ontology:9 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to t-cell defects, has-agent candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

MalaCards based summary: Chronic Mucocutaneous Candidiasis, also known as candidiasis chronic mucocutaneous, is related to candidiasis and keratitis, and has symptoms including hyperkeratosis, skin rash and abnormality of the fingernails. An important gene associated with Chronic Mucocutaneous Candidiasis is IL17F (interleukin 17F), and among its related pathways are Th1 Differentiation and Type II interferon signaling (IFNG). The drugs itraconazole and ketoconazole and the compounds gliadin and flagellin have been mentioned in the context of this disorder. Affiliated tissues include skin, mucous membrane and nail due to t-cell defects, and related mouse phenotypes are normal and cellular.

Wikipedia:63 Chronic mucocutaneous candidiasis is an immune disorder of T cells. It is characterized by chronic... more...

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Chronic Mucocutaneous Candidiasis, Aliases & Descriptions:

Name: Chronic Mucocutaneous Candidiasis 9 41 11 47
Candidiasis Chronic Mucocutaneous 43 22
Chronic Mucocutaneous Candidosis 41 47
 
Mucocutaneous Candidiasis 9 60
Cmc 41 47
Candidiasis, Chronic Mucocutaneous 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

47
chronic mucocutaneous candidiasis:
Inheritance: Autosomal dominant,Autosomal recessive,Not applicable; Age of onset: Infancy


External Ids:

Disease Ontology9 DOID:2058
NCIt38 C34444
MeSH33 D002178
Orphanet47 1334
SNOMED-CT55 234568006
MESH via Orphanet34 D002178
ICD10 via Orphanet26 B37.2
UMLS via Orphanet61 C0006845

Related Diseases for Chronic Mucocutaneous Candidiasis

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Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis32.0CD79A, CARD9, AIRE
2keratitis31.2IL17A
3hypothyroidism31.0AIRE, IFNB1
4autoimmune polyendocrine syndrome31.0CARD9
5thyroiditis30.8CD79A, PTPN22
6hepatitis30.7AIRE, STAT1, IFNB1, IL22
7pneumonia30.7IL17F, IL17A, IL22, CD79A
8influenza30.5STAT1, IFNB1, CD79A
9systemic lupus erythematosus30.5IL17A, CD79A, PTPN22, STAT1, IFNB1
10thymoma10.7
11alopecia10.5
12alopecia areata10.5
13dermatophytosis10.5
14esophagitis10.5
15histoplasmosis10.5
16lupus erythematosus10.5
17aneurysm10.5
18neuromyelitis optica10.4IFNB1
19chronic inflammatory demyelinating polyradiculoneuropathy10.4IFNB1
20coccidioidomycosis10.4CLEC7A
21aplastic anemia10.4
22immunodeficiency 31c, autosomal dominant10.4
23candidiasis, familial, 6, autosomal dominant10.4
24candidiasis, familial, 2, autosomal recessive10.4
25autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.4
26hemolytic anemia10.4
27autoimmune hemolytic anemia10.4
28cerebritis10.4
29hypoparathyroidism10.4
30intracranial aneurysm10.4
31laryngitis10.4
32meningitis10.4
33vasculitis10.4
34toxoplasmosis10.4CD79A
35aspergillosis10.4CD79A
36interstitial lung disease10.4CD79A
37androgen insensitivity, partial, with or without breast cancer10.3
38psoriatic arthritis10.3TRAF3IP2
39mumps10.3STAT1, CD79A
40periodontal disease10.3CD79A
41candidiasis, familial, 810.3
42vici syndrome10.3
43esophageal cancer10.3
44bare lymphocyte syndrome, type ii, complementation group c10.3
45candidiasis, familial, 5, autosomal recessive10.3
46acne10.3
47myasthenia gravis10.3
48rosacea10.3
49pemphigus10.3
50nocardiosis10.3

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to chronic mucocutaneous candidiasis

Symptoms for Chronic Mucocutaneous Candidiasis

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Symptoms:

 47 9 (show all 37)
  • anomalies of mouth, lip and philtrum
  • oral mucosa disease/cheilitis
  • anomalies of skin, subcutaneous tissue and mucosae
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • nails anomalies
  • abnormal fingernails
  • dysplastic/thick/grooved fingernails
  • abnormal toenails
  • dysplastic/thick/grooved toenails
  • anomalies of the immunitary system
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • autosomal dominant inheritance
  • follicular/erythematous/edematous papules/milium
  • vagina anomalies/atresia/hydrometrocolpos/hymen imperforation
  • dyspareunia/coital pain/vaginal dryness
  • anomalies of eyes and vision
  • enamel anomaly
  • pruritus/itching
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • hepatitis/icterus/cholestasis
  • cough
  • hemoptysis
  • repeat respiratory infections
  • endocardium anomalies/fibroelastosis/endocarditis
  • hematuria/microhematuria
  • recurrent urinary infections
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • motor deficit/trouble
  • seizures/epilepsy/absences/spasms/status epilepticus
  • fever/chilling
  • scaling of skin lesions
  • thickening of nails
  • swollen periungal tissue
  • scarring of the scalp

HPO human phenotypes related to Chronic Mucocutaneous Candidiasis:

(show all 19)
id Description Frequency HPO Source Accession
1 hyperkeratosis hallmark (90%) HP:0000962
2 skin rash hallmark (90%) HP:0000988
3 abnormality of the fingernails hallmark (90%) HP:0001231
4 abnormality of the toenail hallmark (90%) HP:0008388
5 cheilitis hallmark (90%) HP:0100825
6 skin ulcer hallmark (90%) HP:0200042
7 abnormality of the vagina typical (50%) HP:0000142
8 recurrent urinary tract infections occasional (7.5%) HP:0000010
9 abnormality of the eye occasional (7.5%) HP:0000478
10 abnormality of dental enamel occasional (7.5%) HP:0000682
11 hematuria occasional (7.5%) HP:0000790
12 pruritus occasional (7.5%) HP:0000989
13 seizures occasional (7.5%) HP:0001250
14 abnormality of the liver occasional (7.5%) HP:0001392
15 hemoptysis occasional (7.5%) HP:0002105
16 recurrent respiratory infections occasional (7.5%) HP:0002205
17 abnormality of the endocardium occasional (7.5%) HP:0004306
18 abnormality of temperature regulation occasional (7.5%) HP:0004370
19 feeding difficulties in infancy occasional (7.5%) HP:0008872

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

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Drug clinical trials:

Search ClinicalTrials for Chronic Mucocutaneous Candidiasis

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Chronic Mucocutaneous Candidiasis

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Genetic tests related to Chronic Mucocutaneous Candidiasis:

id Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis22

Anatomical Context for Chronic Mucocutaneous Candidiasis

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MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

31
Skin, T cells, Eye, Liver, Neutrophil, Bone marrow, Bone, Thymus, Monocytes, Brain, Lung, Thyroid, B cells

FMA organs/tissues related to Chronic Mucocutaneous Candidiasis:

14
Skin, Mucous membrane, Nail due to t-cell defects

Animal Models for Chronic Mucocutaneous Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.3IL17F, CD79A, IFNB1, AIRE, STAT1
2MP:00053847.8CD79A, IL17RA, TRAF3IP2, AIRE, PTPN22, STAT1
3MP:00053887.6IL22, IL17RA, IL17F, IL17A, CLEC7A, PTPN22
4MP:00020067.6STAT1, IFNB1, IL23R, IL22, IL17RA, AIRE
5MP:00053817.6IL22, IL17A, IL17F, STAT1, TRAF3IP2, CLEC7A
6MP:00107687.4CLEC7A, STAT1, IL17A, IL22, IL17F, PTPN22
7MP:00030126.8AIRE, STAT1, IFNB1, IL17A, IL22, IL17RA
8MP:00053765.7IL22, AIRE, IFNB1, CD79A, CARD9, IL17RA
9MP:00053975.2IL22, STAT1, IFNB1, IL17F, TRAF3IP2, IL17A
10MP:00053875.2STAT1, CD79A, CARD9, IL17RA, IL17F, IL22

Publications for Chronic Mucocutaneous Candidiasis

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Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50)    (show all 239)
idTitleAuthorsYear
1
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. (22730530)
2012
2
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. (22403094)
2012
3
Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism. (22847544)
2012
4
Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis? (21988702)
2012
5
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. (21197459)
2011
6
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. (20123958)
2010
7
Autosomal dominant chronic mucocutaneous candidiasis and primary hypothyroidism complicated by oesophageal carcinoma. (19778308)
2009
8
Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED. (19037923)
2008
9
Altered, but not diminished specific T cell response in chronic mucocutaneous candidiasis patients. (17960405)
2007
10
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
11
Disseminated Candida tropicalis in a patient with chronic mucocutaneous candidiasis. (15352680)
2004
12
Polyglandular autoimmune syndrome type 1 without chronic mucocutaneous candidiasis in a 16 year-old male. (12585347)
2003
13
The syndrome of chronic mucocutaneous candidiasis with selective antibody deficiency. (12602677)
2003
14
Histopathologic and scanning electron microscope examination of the nail and hair in chronic mucocutaneous candidiasis. (12894108)
2003
15
Antigliadin antibodies associated with chronic mucocutaneous candidiasis. (12383098)
2002
16
Pneumocystis carinii pneumonia in a 15-year-old with chronic mucocutaneous candidiasis. (10447335)
1999
17
Haemophilus influenzae type D infection and IgG2 deficiency in a patient with chronic mucocutaneous candidiasis. (8203272)
1994
18
Chronic mucocutaneous candidiasis. (8077500)
1994
19
Fatal pulmonary nocardiosis in a patient with chronic mucocutaneous candidiasis. (8064079)
1994
20
Vascular nodules and plaques resembling chronic mucocutaneous candidiasis in a patient with a low interleukin 2 level. (8349866)
1993
21
Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis. (1986107)
1991
22
Chronic mucocutaneous candidiasis. Antibiotic and immunologic therapy. (3214089)
1988
23
KID syndrome (keratitis, ichthyosis, and deafness) and chronic mucocutaneous candidiasis: case report and review of the literature. (6390393)
1984
24
Immunological observations before and after successful treatment of chronic mucocutaneous candidiasis with ketoconazole and transfer factor. (6096150)
1984
25
Chronic mucocutaneous candidiasis. (6317830)
1983
26
Chronic mucocutaneous candidiasis and keratitis associated with malignant thymoma. (6838096)
1983
27
Impaired generation of helper T cells in a patient with chronic mucocutaneous candidiasis and malignant thymoma. (6221110)
1983
28
Treatment of chronic mucocutaneous candidiasis with 5-fluorocytosine. (6756218)
1982
29
Severe hepatitis associated with ketoconazole therapy for chronic mucocutaneous candidiasis. (6284445)
1982
30
Chronic mucocutaneous Candidiasis-endocrinopathies. (7318499)
1981
31
Chronic mucocutaneous candidiasis with candida granuloma treated with 5-fluorocytosine. (7227606)
1981
32
A serum-dependent defect of neutrophil function in chronic mucocutaneous candidiasis. (6995490)
1980
33
Chronic mucocutaneous candidiasis and disseminated histoplasmosis. (7358883)
1980
34
Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. (316285)
1979
35
Immunological investigation of patients with chronic mucocutaneous candidiasis. (399626)
1979
36
Symposium: Chronic mucocutaneous candidiasis. (552463)
1979
37
Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole. (434848)
1979
38
Plasma thymic hormone activity in patients with chronic mucocutaneous candidiasis. (743805)
1978
39
Clotrimazole: intermittent therapy in chronic mucocutaneous candidiasis. (842517)
1977
40
Chronic mucocutaneous candidiasis. Immunologic evaluation and therapy. (844330)
1977
41
Chronic mucocutaneous candidiasis, dermatophytosis and defective cellular immunity in monozygotic twins. (4134659)
1974
42
Chronic mucocutaneous candidiasis. (4470726)
1974
43
Selective hypopituitarism. Impaired cell-mediated immunity and chronic mucocutaneous candidiasis. (4740720)
1973
44
Chronic mucocutaneous candidiasis: iron deficiency and the effects of iron therapy. (4733977)
1973
45
Transfer factor in the treatment of a case of chronic mucocutaneous candidiasis. (4554089)
1972
46
Chronic mucocutaneous candidiasis, myositis, and thymoma. A new triad. (4564702)
1972
47
Treatment of chronic mucocutaneous candidiasis with leucocytes from HL-A compatible sibling. (4109818)
1972
48
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4192497)
1970
49
Transfer of cellular hypersensitivity in chronic mucocutaneous candidiasis monitored in vivo and in vitro. (5523582)
1970
50
Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities. Report of a syndrome of superficial candidiasis, absence of delayed hypersensitivity and aminoaciduria. (5822974)
1969

Variations for Chronic Mucocutaneous Candidiasis

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Clinvar genetic disease variations for Chronic Mucocutaneous Candidiasis:

6 (show all 22)
id Gene Variation Type Significance SNP ID Assembly Location
1STAT1NM_007315.3(STAT1): c.537C> A (p.Asn179Lys)single nucleotide variantPathogenicGRCh37Chr 2, 191864356: 191864356
2STAT1NM_007315.3(STAT1): c.854A> G (p.Gln285Arg)single nucleotide variantPathogenicGRCh37Chr 2, 191859877: 191859877
3STAT1NM_007315.3(STAT1): c.1154C> T (p.Thr385Met)single nucleotide variantPathogenicGRCh37Chr 2, 191851647: 191851647
4STAT1NM_007315.3(STAT1): c.820C> T (p.Arg274Trp)single nucleotide variantPathogenicrs387906758GRCh37Chr 2, 191859911: 191859911
5STAT1NM_007315.3(STAT1): c.800C> T (p.Ala267Val)single nucleotide variantPathogenicrs387906759GRCh37Chr 2, 191859931: 191859931
6STAT1NM_007315.3(STAT1): c.821G> A (p.Arg274Gln)single nucleotide variantPathogenicrs387906760GRCh37Chr 2, 191859910: 191859910
7STAT1NM_007315.3(STAT1): c.857A> T (p.Lys286Ile)single nucleotide variantPathogenicrs387906761GRCh37Chr 2, 191859874: 191859874
8STAT1NM_007315.3(STAT1): c.604A> G (p.Met202Val)single nucleotide variantPathogenicrs387906762GRCh37Chr 2, 191862972: 191862972
9STAT1NM_007315.3(STAT1): c.520T> C (p.Cys174Arg)single nucleotide variantPathogenicrs387906763GRCh37Chr 2, 191864373: 191864373
10STAT1NM_007315.3(STAT1): c.494A> G (p.Asp165Gly)single nucleotide variantPathogenicrs387906764GRCh37Chr 2, 191864399: 191864399
11STAT1NM_007315.3(STAT1): c.862A> G (p.Thr288Ala)single nucleotide variantPathogenicrs387906765GRCh37Chr 2, 191859869: 191859869
12STAT1NM_007315.3(STAT1): c.508T> A (p.Tyr170Asn)single nucleotide variantPathogenicrs387906766GRCh37Chr 2, 191864385: 191864385
13STAT1NM_007315.3(STAT1): c.493G> C (p.Asp165His)single nucleotide variantPathogenicrs387906767GRCh37Chr 2, 191864400: 191864400
14STAT1STAT1, MET202ILEundetermined variantPathogenic
15STAT1NM_007315.3(STAT1): c.812A> C (p.Gln271Pro)single nucleotide variantPathogenicrs387906768GRCh37Chr 2, 191859919: 191859919
16IL17RANM_014339.6(IL17RA): c.850C> T (p.Gln284Ter)single nucleotide variantPathogenicrs387906913GRCh37Chr 22, 17585619: 17585619
17IL17FIL17F, SER65LEUsingle nucleotide variantPathogenic
18CARD9NM_052813.4(CARD9): c.883C> T (p.Gln295Ter)single nucleotide variantPathogenicrs121918338GRCh37Chr 9, 139264814: 139264814
19CARD9NM_052813.4(CARD9): c.214G> A (p.Gly72Ser)single nucleotide variantPathogenicrs398122362GRCh37Chr 9, 139265884: 139265884
20CARD9NM_052813.4(CARD9): c.1118G> C (p.Arg373Pro)single nucleotide variantPathogenicrs149712114GRCh37Chr 9, 139262240: 139262240
21CARD9NM_052813.4(CARD9): c.865C> T (p.Gln289Ter)single nucleotide variantPathogenicrs398122363GRCh37Chr 9, 139264832: 139264832
22CARD9NM_052813.4(CARD9): c.301C> T (p.Arg101Cys)single nucleotide variantPathogenicrs398122364GRCh37Chr 9, 139265797: 139265797

Expression for genes affiliated with Chronic Mucocutaneous Candidiasis

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Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for genes affiliated with Chronic Mucocutaneous Candidiasis

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Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL27-mediated signaling events36
9.8IL17A, STAT1
29.6IFNB1, STAT1
39.6CARD9, IL17RA, CLEC7A
49.4AIRE, CD79A
5
Show member pathways
9.2TRAF3IP2, IL17RA, IL17F, IL17A
6
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.9CLEC7A, STAT1, IFNB1, CARD9
78.9CARD9, IFNB1, STAT1, CLEC7A
8
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.7STAT1, IL17A, IL23R, IL17F
9
Show member pathways
8.4IL17A, IL23R, IL17F, IL17RA, TRAF3IP2
10
Show member pathways
Type III interferon signaling36
8.4STAT1, IFNB1, IL23R, IL22
11
Show member pathways
8.3STAT1, IL17A, IL23R, IL22, IL17F
12
Show member pathways
8.1IL17RA, IL17F, IL22, IL23R, IL17A, STAT1
13
Show member pathways
8.0IFNB1, IL17A, IL23R, IL22, IL17RA

Compounds for genes affiliated with Chronic Mucocutaneous Candidiasis

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Compounds related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 25)
idCompoundScoreTop Affiliating Genes
1gliadin4310.0CD79A, STAT1
2flagellin43 2810.9STAT1, IFNB1
3indoleamine439.9IFNB1, STAT1
4imiquimod43 59 28 1212.8IFNB1, STAT1
5mannan439.8IL17A, CD79A
6inosine monophosphate439.7IFNB1, STAT1
7polyinosinic-polycytidylic acid439.7IFNB1, STAT1
82,5-oligoadenylate439.6IFNB1, STAT1
9poly(i-c)439.6STAT1, IFNB1
10methacholine43 49 1211.5CD79A, IL17A
11mannose439.5CD79A, IL17A, CLEC7A
12ifn-alpha439.5STAT1, IFNB1, IL17A
13endotoxin439.5STAT1, IFNB1, IL17A
14retinoid439.4STAT1, IFNB1, IL17A
15rantes439.3IL17RA, IL17A, IFNB1, STAT1
16methotrexate49 43 1211.2CD79A, IL17A, IFNB1
17pd 98,059439.1IL17A, IFNB1, STAT1
18indomethacin43 28 59 1212.0CD79A, IL17A, IFNB1, STAT1
19sb 20358043 5910.0IL17A, IFNB1, STAT1, AIRE
20pge2439.0CD79A, IL17A, IFNB1, STAT1
21ly294002438.9IL17A, IFNB1, STAT1
22steroid438.9CD79A, IL17A, IFNB1, STAT1
23vegf438.8STAT1, IFNB1, IL17A, CD79A
24dexamethasone43 49 28 1211.6CLEC7A, STAT1, IFNB1, IL17A, CD79A
25tyrosine438.2AIRE, PTPN22, CLEC7A, STAT1, IFNB1, IL17A

GO Terms for genes affiliated with Chronic Mucocutaneous Candidiasis

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Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2CD79A, IL17A, CLEC7A

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-2 biosynthetic processGO:004507610.2CARD9, IL17F
2regulation of interleukin-6 biosynthetic processGO:004540810.2IL17F, CARD9
3fibroblast activationGO:007253710.1IL17A, IL17RA
4positive regulation of interleukin-23 productionGO:003274710.0IL17A, IL17RA
5negative regulation of angiogenesisGO:00165259.9IL17F, STAT1
6positive regulation of cytokine production involved in inflammatory responseGO:019000179.8IL17RA, IL17F, IL17A
7regulation of type I interferon-mediated signaling pathwayGO:00603389.6STAT1, IFNB1
8response to exogenous dsRNAGO:00433309.6STAT1, IFNB1, CARD9
9positive regulation of tumor necrosis factor productionGO:00327609.5CARD9, CLEC7A
10defense response to virusGO:00516079.4STAT1, IFNB1, CARD9
11positive regulation of osteoclast differentiationGO:00456729.4IL23R, IL17A
12B cell proliferationGO:00421009.3CD79A, IFNB1
13humoral immune responseGO:00069599.2TRAF3IP2, IFNB1, AIRE
14cytokine-mediated signaling pathwayGO:00192219.2STAT1, IFNB1, IL17RA
15inflammatory responseGO:00069548.6IL17F, IL22, IL23R, IL17A, CLEC7A
16positive regulation of transcription from RNA polymerase II promoterGO:00459448.6IL17F, IL17A, IFNB1, STAT1, AIRE

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.8IL17F, IL22, IL17A, IFNB1

Products for genes affiliated with Chronic Mucocutaneous Candidiasis

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Sources for Chronic Mucocutaneous Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet