MCID: CHR063
MIFTS: 61

Chronic Mucocutaneous Candidiasis malady

Categories: Rare diseases, Skin diseases, Blood diseases, Infectious diseases

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

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Sources:
11Disease Ontology, 13DISEASES, 26GTR, 30ICD10 via Orphanet, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Chronic Mucocutaneous Candidiasis:

Name: Chronic Mucocutaneous Candidiasis 11 47 53 26 13
Candidiasis, Chronic Mucocutaneous 38 67
 
Cmc 47 53
Candidiasis Chronic Mucocutaneous 49

Characteristics:

Orphanet epidemiological data:

53
chronic mucocutaneous candidiasis:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Childhood,Infancy

Classifications:



External Ids:

Disease Ontology11 DOID:2058
MeSH38 D002178
NCIt44 C34444
Orphanet53 ORPHA1334
SNOMED-CT61 234568006
UMLS via Orphanet68 C0006845
ICD10 via Orphanet30 B37.2
MESH via Orphanet39 D002178

Summaries for Chronic Mucocutaneous Candidiasis

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Disease Ontology:11 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to T-cell defects, has-agent Candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

MalaCards based summary: Chronic Mucocutaneous Candidiasis, also known as candidiasis, chronic mucocutaneous, is related to candidiasis and alopecia, and has symptoms including scaling of skin lesions, thickening of nails and swollen periungal tissue. An important gene associated with Chronic Mucocutaneous Candidiasis is IL17F (Interleukin 17F), and among its related pathways are TSLP Signaling Pathway and TGF Beta Signaling Pathway. The drugs gentian violet and fluconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, mucous membrane and nail due to t-cell defects, and related mouse phenotypes are craniofacial and liver/biliary system.

Wikipedia:70 Chronic mucocutaneous candidiasis is an immune disorder of T cells. It is characterized by chronic... more...

Related Diseases for Chronic Mucocutaneous Candidiasis

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Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 289)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis31.4IL1B, IL6, TNF
2alopecia30.4IL10, IL6, TNF
3hypothyroidism30.1IL1B, IL6, TNF
4autoimmune polyendocrine syndrome30.0IL1B, IL6, TNF
5systemic lupus erythematosus29.5IFNG, IL10, IL2RA, IL6, TNF
6familial candidiasis11.8
7immunodeficiency 31c, autosomal dominant11.7
8candidiasis, familial, 811.7
9candidiasis, familial, 2, autosomal recessive11.4
10candidiasis, familial, 4, autosomal recessive11.4
11candidiasis, familial, 6, autosomal dominant11.3
12candidiasis, familial, 5, autosomal recessive11.3
13autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia11.2
14chronic polyneuropathy10.6IFNG, IL17A, STAT1
15rasmussen subacute encephalitis10.6IL17A, IL17F, IL22
16nevus mucinosis10.5IL10, IL17A
17tetanus neonatorum10.5IFNG, IL10, IL17A
18eye accommodation disease10.5IFNG, IL10, IL2RA
19progressive relapsing multiple sclerosis10.5IFNG, IL10, IL17A
20chronic hiccups10.5IFNG, IL10, IL2RA
21idiopathic neutropenia10.5IFNG, IL10, IL6
22piepkorn karp hickok syndrome10.5IL10, TNF
23benign adult familial myoclonic epilepsy10.4IL10, IL2RA, IL6
24melioidosis10.4IFNG, IL10, IL6
25jejunal somatostatinoma10.4IFNG, IL10, IL6
266q terminal deletion syndrome10.4IL10, TNF
27hypertensive encephalopathy10.4IFNG, IL10, IL17A
28autoimmune myocarditis10.4IL17A, IL2RA, STAT3
29laryngeal cancer, childhood10.4IL2RA, STAT3
30atrichia with papular lesions10.4AIRE, IFNG, TNF
31dentine erosion10.4IFNG, IL1B, STAT1
32tricho odonto onycho dermal syndrome10.4IL17A, IL6, TNF
33panner disease10.4IFNG, IL6, TNF
34addison's disease10.4IFNG, IL10, TNF
35primary orthostatic tremor10.3IFNG, IL10, TNF
36herpangina10.3IFNG, IL10, IL17F, IL6
37meninges hemangiopericytoma10.3IFNG, IL10, TNF
38pasteurellosis10.3IFNG, IL6, TNF
39lymphocytic colitis10.3IFNG, IL6, TNF
40pneumonic tularemia10.3IFNG, IL10, TNF
41sensorineural hearing loss10.3IFNG, IL10, TNF
42allergic hypersensitivity disease10.3IL10, IL17A, TNF
43psychologic dyspareunia10.3IFNG, IL10, TNF
44renal cell carcinoma 410.3IFNG, IL6, TNF
45gastroduodenal crohn's disease10.3IL17A, IL6, TNF
46aortic arch interruption10.3IL6, TNF
47potter's syndrome10.3IFNG, IL2RA, TNF
48hypospadias10.3IFNG, IL10, TNF
49binocular vision disease10.3IFNG, IL10, TNF
50nervous system disease10.3IFNG, IL2RA, IL6, STAT1

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to chronic mucocutaneous candidiasis

Symptoms for Chronic Mucocutaneous Candidiasis

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Symptoms:

 11 (show all 4)
  • scaling of skin lesions
  • thickening of nails
  • swollen periungal tissue
  • scarring of the scalp

Human phenotypes related to Chronic Mucocutaneous Candidiasis:

 53 (show all 31)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent urinary tract infections53 Occasional (29-5%)
2 abnormality of the vagina53 Frequent (79-30%)
3 abnormality of the mouth53 Very frequent (99-80%)
4 abnormality of the lip53 Very frequent (99-80%)
5 abnormality of the eye53 Occasional (29-5%)
6 abnormality of vision53 Occasional (29-5%)
7 abnormality of dental enamel53 Occasional (29-5%)
8 hematuria53 Occasional (29-5%)
9 abnormality of the skin53 Very frequent (99-80%)
10 hyperkeratosis53 Very frequent (99-80%)
11 skin rash53 Very frequent (99-80%)
12 pruritus53 Occasional (29-5%)
13 abnormality of the fingernails53 Very frequent (99-80%)
14 seizures53 Occasional (29-5%)
15 abnormality of the nail53 Very frequent (99-80%)
16 broad nail53 Very frequent (99-80%)
17 hemoptysis53 Occasional (29-5%)
18 recurrent respiratory infections53 Occasional (29-5%)
19 abnormality of the immune system53 Very frequent (99-80%)
20 recurrent infections53 Very frequent (99-80%)
21 abnormality of the endocardium53 Occasional (29-5%)
22 abnormality of temperature regulation53 Occasional (29-5%)
23 abnormality of the toenails53 Very frequent (99-80%)
24 feeding difficulties in infancy53 Occasional (29-5%)
25 erythema53 Very frequent (99-80%)
26 hepatitis53 Occasional (29-5%)
27 cough53 Occasional (29-5%)
28 dyspareunia53 Frequent (79-30%)
29 cheilitis53 Very frequent (99-80%)
30 papule53 Frequent (79-30%)
31 skin ulcer53 Very frequent (99-80%)

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

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Drugs for Chronic Mucocutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Amphotericin Bapproved, investigationalPhase 21181397-89-314956, 5280965
Synonyms:
12633-72-6
1397-89-3
30782-62-8
5-18-10-00525 (Beilstein Handbook Reference)
54482-28-9
8055-20-7
AB00513832
ABLC
AC1L1CN2
AC1L24V6
AC1L70KF
AC1L73U6
AC1NQXTD
AC1NTQ32
AC1NUQG4
AC1NY9JC
AC1O7GCZ
AC1O8FQV
AC1O8PFK
AI3-26528
AMPH-B
AMPH-b
Abelcet
Abelecet
AmBisome (TN)
Ambap1397-89-3
Ambisome
Amfotericina B
Amfotericina B [INN-Spanish]
Ampho-Moronal
Amphocin
Amphomoronal
Amphortericin B
Amphotec
Amphotec (TN)
Amphotericin
Amphotericin .BETA.
Amphotericin B
Amphotericin B (JP15/USP/INN)
Amphotericin B Cholesterol Dispersion
Amphotericin B Colloidal Dispersion
Amphotericin B [USAN:INN:JAN]
Amphotericin B, Lipid-based
Amphotericin B, Streptomyces sp.
Amphotericin-B
Amphotericine B
Amphotericine B [INN-French]
Amphotericinum
Amphotericinum B
Amphotericinum B [INN-Latin]
Amphotherizin
Amphotherizin [German]
Amphotéricine B
Amphozone
BIDD:GT0351
BPBio1_000374
BRN 0078342
BSPBio_000340
C-AmB
C06573
C47H73NO17
CCRIS 5963
CHEBI:2682
CHEMBL1200646
CHEMBL267345
CID10533925
CID10629638
CID10677275
CID14956
CID1972
 
CID352546
CID354192
CID5280965
CID5386092
CID5458486
CID5771695
CID6604295
CID6708817
CID6713692
CID9919339
D00203
DB00681
DivK1c_007045
EINECS 215-742-2
Fungilin
Fungisome
Fungisone
Fungizone
Fungizone (TN)
HMS1569A22
HSDB 3008
HSDB 3008 IAB
Halizon
I06-0257
KBio1_001989
KBio2_000551
KBio2_003119
KBio2_005687
KBioGR_002298
KBioSS_000551
LMPK06000002
LNS-AmB
LS-187721
LS-93
Liposomal Amphotericin B
Liposomal amphotericin b
MLS002702966
MolPort-006-392-260
Mysteclin-F
NCGC00014913
NCGC00090808-01
NCGC00098014-01
NCGC00179595-01
NCI527017
NCI60_004288
NCIStruc1_001042
NCIStruc2_000920
NKTR-024
NS 718
NSC 527017
NSC-527017
NSC527017
Prestwick0_000410
Prestwick1_000410
Prestwick2_000410
Prestwick3_000410
Prestwick_721
SMP1_000302
SMR001566780
SPBio_000715
SPBio_002279
ST50999656
SinuNase
SpecPlus_000949
Spectrum2_000818
Spectrum4_001779
Spectrum_000111
UNII-7XU7A7DROE
amophotericin B
amphotericin B liposomal
amphotericin b
2
Miconazoleapproved, investigational, vet_approvedPhase 2362422916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
3Antiprotozoal AgentsPhase 21986
4Liposomal amphotericin BPhase 2118
5AutoantibodiesPhase 2, Phase 1126
6Antiparasitic AgentsPhase 22127
7Anti-Bacterial AgentsPhase 210884
8Antifungal AgentsPhase 23615
9Anti-Infective AgentsPhase 221402
10
rituximabapprovedPhase 11654174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
11ImmunoglobulinsPhase 16045
12AntibodiesPhase 16045
13Antibodies, MonoclonalPhase 13795
14Antirheumatic AgentsPhase 110627

Interventional clinical trials:

idNameStatusNCT IDPhase
1CAMB/MAT2203 in Patients With Mucocutaneous CandidiasisRecruitingNCT02629419Phase 2
2Rituximab for Anti-cytokine Autoantibody-Associated DiseasesRecruitingNCT01842386Phase 1
3Studies of Disorders With Increased Susceptibility to Fungal InfectionsRecruitingNCT01222741

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: candidiasis, chronic mucocutaneous

Genetic Tests for Chronic Mucocutaneous Candidiasis

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Genetic tests related to Chronic Mucocutaneous Candidiasis:

id Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis26

Anatomical Context for Chronic Mucocutaneous Candidiasis

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MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

35
Skin, T cells, Eye, Neutrophil, Bone marrow, Monocytes, Lung

FMA organs/tissues related to Chronic Mucocutaneous Candidiasis:

17
Skin, Mucous membrane, Nail due to t-cell defects

Animal Models for Chronic Mucocutaneous Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

40 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8CSF1, IFNG, IL10, IL17A, IL17F, TNF
2MP:00053708.3AIRE, CSF1, IFNG, IL10, IL6, STAT1
3MP:00053797.8AIRE, CSF1, IFNG, IL10, IL23R, IL6
4MP:00107717.6CSF1, IFNG, IL10, IL17RA, IL1B, IL6
5MP:00030127.5AIRE, CSF1, IFNG, IL10, IL17A, IL17RA
6MP:00020067.5AIRE, IFNG, IL10, IL17RA, IL1B, IL23A
7MP:00053847.4AIRE, CSF1, IFNG, IL10, IL17RA, IL17RB
8MP:00053917.3AIRE, CSF1, IFNG, IL10, IL6, STAT1
9MP:00053906.9CSF1, IFNG, IL10, IL17A, IL17F, IL17RB
10MP:00053886.8AIRE, CLEC7A, CSF1, IFNG, IL10, IL17A
11MP:00053816.4AIRE, CLEC7A, IFNG, IL10, IL17A, IL17F
12MP:00053786.3AIRE, CSF1, IFNG, IL10, IL17A, IL17F
13MP:00107686.0AIRE, CLEC7A, CSF1, IFNG, IL10, IL17A
14MP:00053765.8AIRE, CLEC7A, CSF1, IFNG, IL10, IL17A
15MP:00053974.8AIRE, CLEC7A, CSF1, IFNG, IL10, IL17A
16MP:00053874.6AIRE, CLEC7A, CSF1, IFNG, IL10, IL17A

Publications for Chronic Mucocutaneous Candidiasis

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Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Chronic mucocutaneous candidiasis: characterization of a family with STAT-1 gain-of-function and development of an ex-vivo assay for Th17 deficiency of diagnostic utility. (26621323)
2016
2
Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. (26948078)
2016
3
Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion. (23791509)
2013
4
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. (22730530)
2012
5
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. (22403094)
2012
6
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. (21197459)
2011
7
Chronic mucocutaneous candidiasis, from bench to bedside. (20133219)
2010
8
Autosomal dominant chronic mucocutaneous candidiasis and primary hypothyroidism complicated by oesophageal carcinoma. (19778308)
2009
9
Chronic mucocutaneous candidiasis and oesophageal cancer. (17852718)
2008
10
Chronic mucocutaneous candidiasis with agammaglobulinaemia. (17567323)
2007
11
Chronic mucocutaneous candidiasis associated with malignant thymoma and systemic lupus erythematosus with hypergammaglobulinemia: a case report and literature review. (16903322)
2006
12
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
13
Chronic mucocutaneous candidiasis in a child. (16394492)
2005
14
Disseminated Candida tropicalis in a patient with chronic mucocutaneous candidiasis. (15352680)
2004
15
Chronic mucocutaneous candidiasis in a 6-year-old boy. (15221041)
2004
16
Polyglandular autoimmune syndrome type 1 without chronic mucocutaneous candidiasis in a 16 year-old male. (12585347)
2003
17
Characterization of the cellular immune function of patients with chronic mucocutaneous candidiasis. (11207655)
2001
18
What syndrome is this? Chronic mucocutaneous candidiasis. (11576415)
2001
19
Autoimmune hemolytic anemia in a patient with autosomal dominant chronic mucocutaneous candidiasis. (10943243)
2000
20
Pneumocystis carinii pneumonia in a 15-year-old with chronic mucocutaneous candidiasis. (10447335)
1999
21
Chronic mucocutaneous candidiasis with widespread dermatophyte infection: the trailing scale sign. (8646859)
1996
22
Chronic mucocutaneous candidiasis. (8077500)
1994
23
Fatal pulmonary nocardiosis in a patient with chronic mucocutaneous candidiasis. (8064079)
1994
24
Disseminated histoplasmosis in chronic mucocutaneous candidiasis. (8516028)
1993
25
Chronic mucocutaneous candidiasis. (2502409)
1989
26
The "yeast connection" meets chronic mucocutaneous candidiasis. (3951526)
1986
27
Chronic mucocutaneous candidiasis. (6317830)
1983
28
Impaired generation of helper T cells in a patient with chronic mucocutaneous candidiasis and malignant thymoma. (6221110)
1983
29
Scanning electron microscopy of oral lesions in chronic mucocutaneous candidiasis. (7001057)
1980
30
Symposium: Chronic mucocutaneous candidiasis. (552463)
1979
31
Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole. (434848)
1979
32
Topical clotrimazole treatment of chronic mucocutaneous candidiasis. (762637)
1979
33
Plasma thymic hormone activity in patients with chronic mucocutaneous candidiasis. (743805)
1978
34
Chronic mucocutaneous candidiasis. Immunologic evaluation and therapy. (844330)
1977
35
An immunological investigation of a family with chronic mucocutaneous candidiasis. (797672)
1976
36
Chronic mucocutaneous candidiasis, dermatophytosis and defective cellular immunity in monozygotic twins. (4134659)
1974
37
Chronic mucocutaneous candidiasis. (4470726)
1974
38
Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man. (4549559)
1974
39
Selective hypopituitarism. Impaired cell-mediated immunity and chronic mucocutaneous candidiasis. (4740720)
1973
40
Chronic mucocutaneous candidiasis: iron deficiency and the effects of iron therapy. (4733977)
1973
41
Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. (4571566)
1973
42
Chronic mucocutaneous candidiasis and alopecia areata. (4706468)
1973
43
Transfer factor in the treatment of a case of chronic mucocutaneous candidiasis. (4554089)
1972
44
Treatment of chronic mucocutaneous candidiasis with leucocytes from HL-A compatible sibling. (4109818)
1972
45
Prolonged oral treatment of chronic mucocutaneous candidiasis with Amphotericin B. (5120161)
1971
46
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4192497)
1970
47
Transfer of cellular hypersensitivity in chronic mucocutaneous candidiasis monitored in vivo and in vitro. (5523582)
1970
48
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4193722)
1970
49
Chronic mucocutaneous candidiasis. (5479318)
1970
50
Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities. Report of a syndrome of superficial candidiasis, absence of delayed hypersensitivity and aminoaciduria. (5822974)
1969

Variations for Chronic Mucocutaneous Candidiasis

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Expression for genes affiliated with Chronic Mucocutaneous Candidiasis

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Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for genes affiliated with Chronic Mucocutaneous Candidiasis

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Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 47)
idSuper pathwaysScoreTop Affiliating Genes
19.2IL2RA, IL6, STAT1, STAT3
29.1IFNG, STAT1, STAT3, TNF
3
Show member pathways
9.1IFNG, IL10, IL2RA, TNF
49.1IL10, IL2RA, IL6, TNF
58.9IFNG, IL10, IL17RB, IL2RA
68.8IFNG, IL1B, IL6, TNF
78.8IFNG, IL6, STAT1, STAT3, TNF
8
Show member pathways
8.7IFNG, IL1B, IL2RA, STAT1, STAT3
98.7CSF1, IL1B, TNF
108.6IFNG, IL10, IL2RA, IL6, STAT1, STAT3
118.6IL10, IL1B, IL6, STAT3, TNF
128.6IL1B, IL6, STAT1, STAT3, TNF
138.6IFNG, IL10, IL1B, IL6, TNF
148.6IFNG, IL10, IL1B, IL6, TNF
158.6IFNG, IL10, IL1B, IL6, TNF
16
Show member pathways
8.6IFNG, IL1B, IL6, STAT1, TNF
17
Show member pathways
8.6IFNG, IL1B, IL6, STAT1, TNF
18
Show member pathways
8.4IFNG, IL1B, STAT1, STAT3, TNF, TRAF3IP2
198.4IL10, IL1B, IL23A, IL6, TNF
20
Show member pathways
8.4IFNG, IL10, IL1B, STAT1, STAT3, TNF
218.4CSF1, IFNG, IL1B, TNF
22
Show member pathways
8.3IFNG, IL10, IL17A, IL1B, IL6, TNF
23
Show member pathways
8.1IL17A, IL17F, IL17RA, IL17RB, IL17RC, IL6
248.1CSF1, IFNG, IL1B, STAT1, TNF
25
Show member pathways
8.1IFNG, IL10, IL17A, IL1B, IL6, STAT1
26
Show member pathways
8.0IFNG, IL10, IL1B, IL6, STAT1, STAT3
278.0CSF1, IL1B, IL2RA, IL6, TNF
287.9CSF1, IFNG, IL10, IL2RA, IL6, TNF
29
Show member pathways
7.9IFNG, IL1B, IL2RA, IL6, STAT1, STAT3
307.8CLEC7A, IFNG, IL10, IL1B, IL2RA, STAT1
317.8CSF1, IFNG, IL10, IL1B, IL6, TNF
327.6CLEC7A, IFNG, IL10, IL1B, IL23A, IL6
337.2CSF1, IFNG, IL17A, IL1B, IL23A, IL6
347.1CSF1, IFNG, IL10, IL17RA, IL1B, IL23A
357.0CSF1, IL10, IL17A, IL1B, IL22, IL23A
36
Show member pathways
6.9IFNG, IL17A, IL17F, IL17RA, IL1B, IL22
37
Show member pathways
6.8IFNG, IL10, IL17A, IL17RC, IL1B, IL22
38
Show member pathways
6.8IFNG, IL10, IL17A, IL1B, IL23A, IL23R
39
Show member pathways
6.6IFNG, IL10, IL17A, IL17F, IL1B, IL23A
406.5IFNG, IL10, IL17A, IL17RB, IL1B, IL22
41
Show member pathways
6.4IFNG, IL10, IL17A, IL17RC, IL1B, IL22
42
Show member pathways
6.4IFNG, IL10, IL17A, IL17F, IL1B, IL22
43
Show member pathways
5.8CSF1, IL10, IL17A, IL17RA, IL17RC, IL1B
44
Show member pathways
5.3CSF1, IL10, IL17A, IL17RA, IL17RC, IL1B
45
Show member pathways
5.3CSF1, IL10, IL17A, IL17RA, IL17RC, IL1B
46
Show member pathways
5.0CLEC7A, IFNG, IL17A, IL17F, IL17RA, IL17RB
47
Show member pathways
4.6CSF1, IFNG, IL10, IL17A, IL17RA, IL17RB

GO Terms for genes affiliated with Chronic Mucocutaneous Candidiasis

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Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.8IFNG, IL17A, IL2RA, IL6, TNF
2extracellular spaceGO:00056156.5CSF1, IFNG, IL10, IL17A, IL17F, IL1B
3extracellular regionGO:00055766.5IFNG, IL17A, IL17F, IL17RA, IL17RB, IL1B

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:007253710.7IL17A, IL17RA
2granulocyte chemotaxisGO:007162110.7IL17RA, IL17RC
3neutrophil apoptotic processGO:000178110.6IFNG, IL6
4receptor biosynthetic processGO:003280010.5IL10, TNF
5positive regulation of interleukin-5 secretionGO:200066410.4IL17RA, IL17RB
6positive regulation of vitamin D biosynthetic processGO:006055710.4IFNG, TNF
7positive regulation of interleukin-13 secretionGO:200066710.4IL17RA, IL17RB
8regulation of tyrosine phosphorylation of Stat1 proteinGO:004251010.3IL23A, IL23R
9positive regulation of T-helper 17 cell lineage commitmentGO:200033010.3IL23A, IL23R
10positive regulation of tyrosine phosphorylation of Stat4 proteinGO:004252010.3IL23A, IL23R
11positive regulation of NK T cell activationGO:005113510.3IL23A, IL23R
12positive regulation of cytokine production involved in inflammatory responseGO:190001710.3IL17A, IL17F, IL17RA, IL17RC
13positive regulation of interleukin-23 productionGO:003274710.3IFNG, IL17A, IL17RA
14defense response to fungusGO:005083210.3IL17A, IL17RA, IL17RC
15positive regulation of activation of JAK2 kinase activityGO:001053510.2IL23A, IL23R
16sequestering of triglycerideGO:003073010.2IL1B, TNF
17chronic inflammatory response to antigenic stimulusGO:000243910.2IL1B, TNF
18acute-phase responseGO:000695310.1IL22, IL6, STAT3
19positive regulation of JAK-STAT cascadeGO:004642710.0IL10, IL22, IL6
20positive regulation of interleukin-6 secretionGO:200077810.0IL17A, IL17F, IL17RC, IL1B
21negative regulation of growth of symbiont in hostGO:004413010.0IFNG, IL10, TNF
22defense response to protozoanGO:004283210.0CLEC7A, IFNG, IL10, IL6
23positive regulation of calcidiol 1-monooxygenase activityGO:00605599.9IFNG, IL1B, TNF
24positive regulation of membrane protein ectodomain proteolysisGO:00510449.9IFNG, IL1B, TNF
25positive regulation of chemokine biosynthetic processGO:00450809.9IFNG, IL1B, TNF
26positive regulation of interleukin-12 productionGO:00327359.9IFNG, IL23A, IL23R
27positive regulation of activated T cell proliferationGO:00421049.8IL23A, IL23R, IL2RA
28response to glucocorticoidGO:00513849.7IL10, IL22, IL6, TNF
29cellular response to lipopolysaccharideGO:00712229.6IFNG, IL10, IL6, TNF
30positive regulation of interleukin-6 productionGO:00327559.6IL1B, IL6, TNF
31positive regulation of NF-kappaB import into nucleusGO:00423469.6IL1B, IL23A, TNF
32humoral immune responseGO:00069599.5AIRE, IFNG, IL6, TNF, TRAF3IP2
33positive regulation of granulocyte macrophage colony-stimulating factor productionGO:00327259.5IL1B, IL23A, IL23R
34positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.5IL23A, IL23R, IL6, STAT3
35cellular response to cytokine stimulusGO:00713459.4IL17RA, IL6, STAT1, STAT3
36positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.4IL10, IL1B, IL6, TNF
37defense response to virusGO:00516079.4IFNG, IL23A, IL6, STAT1
38immune responseGO:00069559.4AIRE, IL10, IL17A, IL22, IL2RA
39defense response to Gram-negative bacteriumGO:00508299.3IL23A, IL23R, IL6
40cellular response to organic cyclic compoundGO:00714079.3IL1B, STAT1, STAT3, TNF
41positive regulation of interferon-gamma productionGO:00327299.2IL1B, IL23A, IL23R, TNF
42positive regulation of nitric oxide biosynthetic processGO:00454299.1IFNG, IL1B, IL6, TNF
43cytokine-mediated signaling pathwayGO:00192218.8IL17RA, IL17RB, IL17RC, IL1B, IL6, STAT3
44response to drugGO:00424938.7IFNG, IL10, IL6, STAT1, STAT3
45positive regulation of T cell proliferationGO:00421028.4IFNG, IL1B, IL23A, IL23R, IL2RA, IL6
46positive regulation of osteoclast differentiationGO:00456728.3CSF1, IFNG, IL17A, IL23A, IL23R, TNF
47positive regulation of transcription, DNA-templatedGO:00458938.1AIRE, IFNG, IL10, IL1B, IL6, STAT1
48positive regulation of gene expressionGO:00106287.9CSF1, IFNG, IL1B, IL6, STAT3, TNF
49positive regulation of transcription from RNA polymerase II promoterGO:00459446.8AIRE, IFNG, IL10, IL17A, IL17F, IL1B
50inflammatory responseGO:00069546.2CLEC7A, CSF1, IL10, IL17A, IL17F, IL1B

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CCR5 chemokine receptor bindingGO:003173010.6STAT1, STAT3
2interleukin-17 receptor activityGO:003036810.3IL17RA, IL17RB, IL17RC
3cytokine activityGO:00051257.1CSF1, IFNG, IL10, IL17A, IL17F, IL1B
4protein bindingGO:00055154.6AIRE, CLEC7A, CSF1, IFNG, IL10, IL17A

Sources for Chronic Mucocutaneous Candidiasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet