CMC
MCID: CHR063
MIFTS: 63

Chronic Mucocutaneous Candidiasis (CMC) malady

Categories: Rare diseases, Skin diseases, Blood diseases, Infectious diseases

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

Aliases & Descriptions for Chronic Mucocutaneous Candidiasis:

Name: Chronic Mucocutaneous Candidiasis 12 50 56 29 14
Candidiasis, Chronic Mucocutaneous 42 69
Cmc 50 56
Candidiasis Chronic Mucocutaneous 52

Characteristics:

Orphanet epidemiological data:

56
chronic mucocutaneous candidiasis
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Childhood,Infancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:2058
MeSH 42 D002178
NCIt 47 C34444
SNOMED-CT 64 234568006
Orphanet 56 ORPHA1334
UMLS via Orphanet 70 C0006845
ICD10 via Orphanet 34 B37.2
MESH via Orphanet 43 D002178
UMLS 69 C0006845

Summaries for Chronic Mucocutaneous Candidiasis

Disease Ontology : 12 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to T-cell defects, has-agent Candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

MalaCards based summary : Chronic Mucocutaneous Candidiasis, also known as candidiasis, chronic mucocutaneous, is related to rosacea and hepatitis, and has symptoms including scaling of skin lesions, thickening of nails and swollen periungal tissue. An important gene associated with Chronic Mucocutaneous Candidiasis is IL17F (Interleukin 17F), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Miconazole and Antifungal Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and eye, and related phenotypes are hematopoietic system and immune system

Wikipedia : 71 Chronic mucocutaneous candidiasis is an immune disorder of T cells. It is characterized by chronic... more...

Related Diseases for Chronic Mucocutaneous Candidiasis

Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
id Related Disease Score Top Affiliating Genes
1 rosacea 29.9 IFNG IL10 IL1B
2 hepatitis 29.7 CLEC7A IFNG IL10 IL6 TNF
3 familial candidiasis 11.8
4 candidiasis, familial, 8 11.7
5 immunodeficiency 31c, autosomal dominant 11.7
6 candidiasis, familial, 2, autosomal recessive 11.4
7 candidiasis, familial, 4, autosomal recessive 11.3
8 candidiasis, familial, 6, autosomal dominant 11.3
9 candidiasis, familial, 5, autosomal recessive 11.3
10 autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia 11.2
11 candidiasis 11.0
12 primary non-gestational choriocarcinoma of ovary 10.3 IL17A IL17F IL22
13 asymptomatic neurosyphilis 10.3 IFNG IL10 IL2RA
14 ciliary discoordination, due to random ciliary orientation 10.3 IFNG IL10 IL2RA
15 reproductive system disease 10.3 IL10 IL17A IL6
16 loiasis 10.3 IFNG IL10 IL17A
17 smooth muscle tumor 10.3 IL17A IL2RA IL6
18 multiple mitochondrial dysfunctions syndrome 10.2 IFNG IL10 IL6
19 autoimmune retinopathy 10.2 IL17A IL2RA STAT3
20 ethmoid sinus cancer 10.2 IFNG IL1B STAT1
21 usher syndrome, type 2a 10.2 IFNG IL10 IL6
22 thymoma 10.2
23 pyridoxal 5'-phosphate-dependent epilepsy 10.2 IL10 TNF
24 lepromatous leprosy 10.2 IFNG IL10 IL17F IL6
25 aniseikonia 10.2 IFNG IL17A TNF
26 periventricular leukomalacia 10.2 IFNG IL17A IL1B
27 isolated growth hormone deficiency 10.2 IFNG IL1B STAT1
28 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 TNF
29 non-gestational choriocarcinoma 10.2 IFNG IL10 IL17A STAT3
30 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
31 childhood electroclinical syndrome 10.2 IL10 IL1B IL6
32 causalgia 10.2 IFNG IL10 IL2RA IL6
33 plantar wart 10.2 IFNG IL10 TNF
34 oral cavity carcinoma in situ 10.2 IFNG IL10 IL1B
35 osteodysplasty precocious of danks mayne and kozlowski 10.2 IFNG IL10 TNF
36 parametritis 10.2 IFNG IL2RA TNF
37 neurotic disorder 10.2 IFNG IL10 TNF
38 esophagus lymphoma 10.2 IFNG IL6 TNF
39 cryptococcosis 10.2 IL10 IL17A TNF
40 clostridium difficile colitis 10.2 IFNG IL6 TNF
41 pulpitis 10.2 IFNG IL10 TNF
42 intussusception 10.2 IL1B TNF
43 tularemia 10.2 IFNG IL10 TNF
44 glucose intolerance 10.2 IFNG IL2RA TNF
45 transient tic disorder 10.1 IL10 IL6 TNF
46 microcephaly 10.1 IFNG IL10 TNF
47 urea cycle disorder 10.1 IL10 IL1B IL6
48 hyperimmunoglobulin syndrome 10.1 IFNG STAT1 TNF
49 abnormal retinal correspondence 10.1 IFNG IL10 TNF
50 aortic coarctation 10.1 IL2RA IL6 TNF

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to Chronic Mucocutaneous Candidiasis

Symptoms & Phenotypes for Chronic Mucocutaneous Candidiasis

Symptoms:

12
  • scaling of skin lesions
  • thickening of nails
  • swollen periungal tissue
  • scarring of the scalp

Human phenotypes related to Chronic Mucocutaneous Candidiasis:

56 32 (show all 31)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 56 32 Occasional (29-5%) HP:0000989
2 seizures 56 32 Occasional (29-5%) HP:0001250
3 hemoptysis 56 32 Occasional (29-5%) HP:0002105
4 recurrent respiratory infections 56 32 Occasional (29-5%) HP:0002205
5 feeding difficulties in infancy 56 32 Occasional (29-5%) HP:0008872
6 abnormality of vision 56 32 Occasional (29-5%) HP:0000504
7 hepatitis 56 32 Occasional (29-5%) HP:0012115
8 hyperkeratosis 56 32 Very frequent (99-80%) HP:0000962
9 abnormality of the fingernails 56 32 Very frequent (99-80%) HP:0001231
10 abnormality of temperature regulation 56 32 Occasional (29-5%) HP:0004370
11 skin ulcer 56 32 Very frequent (99-80%) HP:0200042
12 hematuria 56 32 Occasional (29-5%) HP:0000790
13 abnormality of the endocardium 56 32 Occasional (29-5%) HP:0004306
14 abnormality of dental enamel 56 32 Occasional (29-5%) HP:0000682
15 cheilitis 56 32 Very frequent (99-80%) HP:0100825
16 erythema 56 32 Very frequent (99-80%) HP:0010783
17 skin rash 56 32 Very frequent (99-80%) HP:0000988
18 cough 56 32 Occasional (29-5%) HP:0012735
19 recurrent urinary tract infections 56 32 Occasional (29-5%) HP:0000010
20 papule 56 32 Frequent (79-30%) HP:0200034
21 abnormality of the vagina 56 32 Frequent (79-30%) HP:0000142
22 abnormality of the toenails 56 32 Very frequent (99-80%) HP:0008388
23 dyspareunia 56 32 Frequent (79-30%) HP:0030016
24 broad nail 56 32 Very frequent (99-80%) HP:0001821
25 abnormality of the eye 56 Occasional (29-5%)
26 abnormality of the nail 56 Very frequent (99-80%)
27 abnormality of the mouth 56 Very frequent (99-80%)
28 abnormality of the immune system 56 Very frequent (99-80%)
29 recurrent infections 56 Very frequent (99-80%)
30 abnormality of the lip 56 Very frequent (99-80%)
31 abnormality of the skin 56 Very frequent (99-80%)

MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.45 AIRE CLEC7A CSF1 IFNG IL10 IL17A
2 immune system MP:0005387 10.43 IL10 IL17A IL17F IL17RA IL17RB IL17RC
3 digestive/alimentary MP:0005381 10.41 TNF TRAF3IP2 AIRE CLEC7A IFNG IL10
4 homeostasis/metabolism MP:0005376 10.41 IL2RA IL6 STAT1 STAT3 TNF TRAF3IP2
5 growth/size/body region MP:0005378 10.36 AIRE CSF1 IFNG IL10 IL17A IL17F
6 cellular MP:0005384 10.3 TNF TRAF3IP2 AIRE CSF1 IFNG IL10
7 endocrine/exocrine gland MP:0005379 10.3 AIRE CSF1 IFNG IL10 IL17A IL23R
8 mortality/aging MP:0010768 10.24 AIRE CLEC7A CSF1 IFNG IL10 IL17A
9 craniofacial MP:0005382 10.15 CSF1 IFNG IL10 IL17A IL17F STAT3
10 integument MP:0010771 10.13 CSF1 IFNG STAT3 TNF TRAF3IP2 IL10
11 neoplasm MP:0002006 10.06 AIRE IFNG IL10 IL17RA IL1B IL23A
12 liver/biliary system MP:0005370 10.01 AIRE CSF1 IFNG IL10 IL6 STAT1
13 respiratory system MP:0005388 10 IL17RA IL17RB IL2RA IL6 STAT3 TNF
14 no phenotypic analysis MP:0003012 9.96 AIRE CSF1 IFNG IL10 IL17A IL17RA
15 skeleton MP:0005390 9.7 IL17RB IL1B IL6 STAT1 STAT3 TNF
16 vision/eye MP:0005391 9.32 CSF1 IFNG IL10 IL2RA IL6 STAT1

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

Drugs for Chronic Mucocutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
2 Antifungal Agents Phase 3,Phase 2
3
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Liposomal amphotericin B Phase 2
7 Autoantibodies Phase 2,Phase 1
8 Antiparasitic Agents Phase 2
9 Antiprotozoal Agents Phase 2
10
rituximab Approved Phase 1 174722-31-7 10201696
11 Immunoglobulins Phase 1
12 Antibodies, Monoclonal Phase 1
13 Antibodies Phase 1
14 Antirheumatic Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Open-Label Study to Evaluate Efficacy and Safety of SCY-078 in Patients With Refractory or Intolerant Fungal Diseases Recruiting NCT03059992 Phase 3
2 CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis Recruiting NCT02629419 Phase 2
3 Rituximab for Anti-cytokine Autoantibody-Associated Diseases Recruiting NCT01842386 Phase 1
4 Studies of Disorders With Increased Susceptibility to Fungal Infections Recruiting NCT01222741

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: candidiasis, chronic mucocutaneous

Genetic Tests for Chronic Mucocutaneous Candidiasis

Genetic tests related to Chronic Mucocutaneous Candidiasis:

id Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis 29

Anatomical Context for Chronic Mucocutaneous Candidiasis

MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

39
Skin, T Cells, Eye, Neutrophil, Lung, Monocytes, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Chronic Mucocutaneous Candidiasis:

18
Skin, Mucous Membrane, Nail Due To T-Cell Defects

Publications for Chronic Mucocutaneous Candidiasis

Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50) (show all 260)
id Title Authors Year
1
A Novel Heterozygous Mutation in the STAT1 SH2 Domain Causes Chronic Mucocutaneous Candidiasis, Atypically Diverse Infections, Autoimmunity, and Impaired Cytokine Regulation. ( 28348565 )
2017
2
Chronic Mucocutaneous Candidiasis. ( 28065688 )
2017
3
New and recurrent STAT1 mutations in seven Chinese patients with chronic mucocutaneous candidiasis. ( 27808400 )
2017
4
Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. ( 26948078 )
2016
5
Th2 and Th9 responses in patients with chronic mucocutaneous candidiasis and hyper-IgE syndrome. ( 27474157 )
2016
6
Treatment options for chronic mucocutaneous candidiasis. ( 27161991 )
2016
7
Chronic mucocutaneous candidiasis disease associated with inborn errors of IL-17 immunity. ( 28090315 )
2016
8
Clinical and immunological data of nine patients with chronic mucocutaneous candidiasis disease. ( 26981552 )
2016
9
Chronic mucocutaneous candidiasis: characterization of a family with STAT-1 gain-of-function and development of an ex-vivo assay for Th17 deficiency of diagnostic utility. ( 26621323 )
2016
10
The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1. ( 26604104 )
2016
11
Chronic mucocutaneous candidiasis presenting as Candida endophthalmitis. ( 27085277 )
2016
12
Ruxolitinib Induces Interleukin 17 and Ameliorates Chronic Mucocutaneous Candidiasis Caused by STAT1 Gain-of-Function Mutation. ( 26787170 )
2016
13
Clinical heterogeneity of dominant chronic mucocutaneous candidiasis disease: presenting as treatment-resistant candidiasis and chronic lung disease. ( 26732859 )
2016
14
Clonal Strain Persistence of Candida albicans Isolates from Chronic Mucocutaneous Candidiasis Patients. ( 26849050 )
2016
15
Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. ( 25918342 )
2015
16
Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation. ( 25662309 )
2015
17
Recurrent inflammatory aortic aneurysms in chronic mucocutaneous candidiasis with a gain-of-function STAT1 mutation. ( 26080282 )
2015
18
A novel gain-of-function STAT1 mutation resulting in basal phosphorylation of STAT1 and increased distal IFN-I^-mediated responses in chronic mucocutaneous candidiasis. ( 26514428 )
2015
19
A STAT1-gain-of-function mutation causing Th17 deficiency with chronic mucocutaneous candidiasis, psoriasiform hyperkeratosis and dermatophytosis. ( 26494717 )
2015
20
Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). ( 26255980 )
2015
21
Immunotherapy with G-CSF in patients with chronic mucocutaneous candidiasis. ( 25999307 )
2015
22
Two Novel Gain-of-Function Mutations of STAT1 Responsible for Chronic Mucocutaneous Candidiasis Disease: Impaired Production of IL-17A and IL-22, and the Presence of Anti-IL-17F Autoantibody. ( 25288569 )
2014
23
Altered immune responses in patients with chronic mucocutaneous candidiasis. ( 24582143 )
2014
24
Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): Chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding. ( 25042743 )
2014
25
Chronic mucocutaneous candidiasis: a case with exuberant cutaneous horns in nipples. ( 25054753 )
2014
26
Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis. ( 24343863 )
2013
27
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis. ( 24240291 )
2013
28
Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1. ( 23122533 )
2013
29
New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe. ( 23709754 )
2013
30
Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion. ( 23791509 )
2013
31
Autosomal dominant cases of chronic mucocutaneous candidiasis segregates with mutations of signal transducer and activator of transcription 1, but not of Toll-like receptor 3. ( 23541088 )
2013
32
IL-17 T Cells' Defective Differentiation In Vitro Despite Normal Range Ex Vivo in Chronic Mucocutaneous Candidiasis Due to STAT1 Mutation. ( 24335902 )
2013
33
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. ( 24120361 )
2013
34
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. ( 22403094 )
2012
35
Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism. ( 22847544 )
2012
36
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. ( 22730530 )
2012
37
Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis? ( 21988702 )
2012
38
Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. ( 23026768 )
2012
39
Fungal granuloma of the brain in a case of chronic mucocutaneous candidiasis. ( 22724885 )
2012
40
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. ( 21727188 )
2011
41
Invariant natural killer T (iNKT) cell deficiency in chronic mucocutaneous candidiasis--a consequence or a cause? ( 20923687 )
2011
42
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. ( 21197459 )
2011
43
Defects in interleukin-17 immunity in the pathogenesis of chronic mucocutaneous candidiasis. ( 21766202 )
2011
44
STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis. ( 22195034 )
2011
45
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. ( 21350122 )
2011
46
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. ( 21714643 )
2011
47
Chronic mucocutaneous candidiasis and congenital susceptibility to Candida. ( 20859203 )
2010
48
Impaired T(H)17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. ( 20934207 )
2010
49
Chronic mucocutaneous candidiasis, from bench to bedside. ( 20133219 )
2010
50
Anti-cytokine autoantibodies explain some chronic mucocutaneous candidiasis. ( 20548324 )
2010

Variations for Chronic Mucocutaneous Candidiasis

Expression for Chronic Mucocutaneous Candidiasis

Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for Chronic Mucocutaneous Candidiasis

Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CLEC7A CSF1 IFNG IL10 IL17A IL17F
2
Show member pathways
13.96 CSF1 IL10 IL17A IL17RA IL17RC IL1B
3
Show member pathways
13.76 CSF1 IFNG IL10 IL17A IL17F IL17RA
4
Show member pathways
13.66 IFNG IL10 IL17A IL17RC IL1B IL22
5
Show member pathways
13.54 CSF1 IL10 IL17A IL17RA IL17RC IL1B
6
Show member pathways
13.47 CSF1 IFNG IL10 IL17A IL17F IL17RA
7
Show member pathways
13.45 CSF1 IL10 IL17A IL17RA IL17RC IL1B
8
Show member pathways
13.03 IFNG IL10 IL1B IL6 STAT1 STAT3
9
Show member pathways
13.03 IFNG IL10 IL17A IL1B IL22 IL2RA
10
Show member pathways
12.93 IFNG IL1B IL2RA IL6 STAT1 STAT3
11
Show member pathways
12.89 IL22 IL2RA IL6 STAT1 STAT3 TNF
12
Show member pathways
12.79 IFNG IL1B STAT1 STAT3 TNF TRAF3IP2
13
Show member pathways
12.75 IFNG IL10 IL17A IL17F IL1B IL23A
14
Show member pathways
12.75 IFNG IL10 IL17A IL17F IL1B IL22
15 12.71 IFNG IL10 IL17A IL1B IL2RA STAT1
16
Show member pathways
12.57 IFNG IL10 IL17A IL1B IL6 TNF
17
Show member pathways
12.45 CSF1 IFNG IL1B IL6 TNF
18
Show member pathways
12.44 IFNG IL17A IL17F IL17RA IL17RB IL17RC
19 12.42 CLEC7A IFNG IL10 IL1B IL23A IL6
20
Show member pathways
12.41 IFNG IL10 IL1B STAT1 STAT3 TNF
21
Show member pathways
12.4 IFNG IL1B IL6 STAT1 TNF
22
Show member pathways
12.4 IFNG IL10 IL22 IL23A IL23R IL2RA
23
Show member pathways
12.37 IFNG IL6 STAT1 STAT3
24
Show member pathways
12.35 IFNG IL10 IL17A IL1B IL6 STAT1
25
Show member pathways
12.32 IFNG IL1B IL6 STAT1 TNF
26 12.32 IFNG IL6 STAT1 STAT3 TNF
27 12.26 IL10 IL1B IL6 TNF
28 12.19 CSF1 IFNG IL1B STAT1 TNF
29 12.18 CSF1 IFNG IL10 IL2RA IL6 TNF
30
Show member pathways
12.17 IFNG IL2RA STAT1 STAT3
31 12.16 IL6 STAT1 STAT3 TNF
32
Show member pathways
12.13 IL1B IL2RA STAT1 STAT3
33
Show member pathways
12.12 IFNG IL1B IL2RA STAT1 STAT3
34 12.11 IFNG IL1B IL6 TNF
35
Show member pathways
12.07 IFNG IL17A IL17F IL17RA IL1B IL22
36 12.06 CSF1 IL1B IL6 TNF
37 12.06 IL1B IL6 STAT1 STAT3 TNF
38 12.06 CSF1 IFNG IL17A IL1B IL23A IL6
39 12.05 CSF1 IL1B IL2RA IL6 TNF
40 12.04 IFNG IL10 IL1B IL6 TNF
41
Show member pathways
11.99 IFNG IL1B STAT1 STAT3
42
Show member pathways
11.99 IFNG IL10 IL17A IL1B IL23A IL23R
43 11.98 CSF1 IFNG IL10 IL17RA IL1B IL23A
44 11.97 IL23R IL2RA STAT1 STAT3
45 11.93 IL10 IL1B IL23A IL6 TNF
46 11.91 IFNG IL10 IL2RA IL6 STAT1 STAT3
47 11.86 IL10 IL2RA IL6 TNF
48 11.85 IFNG IL6 STAT1
49
Show member pathways
11.81 IFNG IL2RA TNF
50
Show member pathways
11.8 IFNG IL1B IL6 TNF

GO Terms for Chronic Mucocutaneous Candidiasis

Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 CSF1 IFNG IL10 IL17A IL17F IL1B
2 external side of plasma membrane GO:0009897 9.55 IFNG IL17A IL2RA IL6 TNF
3 extracellular region GO:0005576 9.4 CSF1 IFNG IL10 IL17A IL17F IL17RA

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.97 IFNG IL10 IL6 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.97 IL17RA IL17RB IL17RC IL1B IL6 STAT3
3 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.95 IL10 IL1B IL6 TNF
4 cellular response to organic cyclic compound GO:0071407 9.92 IL1B STAT3 TNF
5 regulation of insulin secretion GO:0050796 9.92 IFNG IL1B TNF
6 response to glucocorticoid GO:0051384 9.92 IL10 IL22 IL6 TNF
7 response to cytokine GO:0034097 9.91 IL6 STAT1 STAT3
8 immune response GO:0006955 9.91 AIRE IFNG IL10 IL17A IL1B IL23A
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 IL6 STAT1 TNF
10 positive regulation of inflammatory response GO:0050729 9.9 IL17RA IL17RB IL23A
11 defense response to Gram-negative bacterium GO:0050829 9.9 IL23A IL23R IL6
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 IFNG IL23A IL23R IL6
13 positive regulation of interleukin-6 production GO:0032755 9.87 IL1B IL6 TNF
14 positive regulation of interferon-gamma production GO:0032729 9.86 IL1B IL23A IL23R TNF
15 acute-phase response GO:0006953 9.85 IL22 IL6 STAT3
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IFNG IL1B IL6 TNF
17 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.84 IL23A IL23R IL6 STAT3
18 defense response to fungus GO:0050832 9.83 IL17A IL17RA IL17RC
19 cellular response to cytokine stimulus GO:0071345 9.83 IL17RA IL6 STAT3
20 positive regulation of activated T cell proliferation GO:0042104 9.82 IL23A IL23R IL2RA
21 positive regulation of interleukin-12 production GO:0032735 9.81 IFNG IL23A IL23R
22 positive regulation of NF-kappaB import into nucleus GO:0042346 9.8 IL1B IL23A TNF
23 positive regulation of defense response to virus by host GO:0002230 9.8 IL23A IL23R TRAF3IP2
24 humoral immune response GO:0006959 9.8 AIRE IFNG IL6 TNF TRAF3IP2
25 negative regulation of growth of symbiont in host GO:0044130 9.79 IFNG IL10 TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.78 IFNG IL1B TNF
27 positive regulation of interleukin-6 secretion GO:2000778 9.78 IL17A IL17F IL17RC IL1B
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
29 defense response to protozoan GO:0042832 9.76 CLEC7A IFNG IL10 IL6
30 negative regulation of interleukin-10 production GO:0032693 9.75 IL23A IL23R
31 positive regulation of T cell mediated cytotoxicity GO:0001916 9.75 IL23A IL23R
32 positive regulation of protein import into nucleus, translocation GO:0033160 9.75 IFNG IL6
33 positive regulation of T-helper 1 type immune response GO:0002827 9.75 IL23A IL23R
34 positive regulation of chemokine biosynthetic process GO:0045080 9.75 IFNG IL1B TNF
35 negative regulation of lipid storage GO:0010888 9.74 IL6 TNF
36 interleukin-6-mediated signaling pathway GO:0070102 9.74 IL6 STAT3
37 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.74 IFNG IL1B
38 endothelial cell apoptotic process GO:0072577 9.74 IL10 TNF
39 regulation of defense response to virus by host GO:0050691 9.74 IFNG IL1B
40 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B IL23A IL23R
41 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IFNG IL10
42 regulation of establishment of endothelial barrier GO:1903140 9.73 IL1B TNF
43 positive regulation of natural killer cell proliferation GO:0032819 9.72 IL23A IL23R
44 positive regulation of activation of JAK2 kinase activity GO:0010535 9.72 IL23A IL23R
45 positive regulation of activation of Janus kinase activity GO:0010536 9.72 IL23A IL23R
46 negative regulation of cytokine secretion involved in immune response GO:0002740 9.71 IL10 TNF
47 T-helper 17 cell lineage commitment GO:0072540 9.71 IL6 STAT3
48 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.71 IL6 TNF
49 positive regulation of T-helper 17 type immune response GO:2000318 9.71 IL23A IL23R
50 positive regulation of interleukin-13 secretion GO:2000667 9.71 IL17RA IL17RB

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CSF1 IFNG IL10 IL17A IL17F IL1B
2 interleukin-17 receptor activity GO:0030368 9.13 IL17RA IL17RB IL17RC

Sources for Chronic Mucocutaneous Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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