MCID: CHR063
MIFTS: 61

Chronic Mucocutaneous Candidiasis malady

Categories: Skin diseases, Blood diseases, Rare diseases, Infectious diseases

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 25GTR, 48Novoseek, 37MeSH, 66UMLS, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Chronic Mucocutaneous Candidiasis:

Name: Chronic Mucocutaneous Candidiasis 11 46 13 52 25
Candidiasis, Chronic Mucocutaneous 37 66
 
Cmc 46 52
Candidiasis Chronic Mucocutaneous 48

Characteristics:

Orphanet epidemiological data:

52
chronic mucocutaneous candidiasis:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Childhood,Infancy

Classifications:



External Ids:

Disease Ontology11 DOID:2058
MeSH37 D002178
NCIt43 C34444
Orphanet52 ORPHA1334
SNOMED-CT60 234568006
ICD10 via Orphanet29 B37.2
MESH via Orphanet38 D002178
UMLS via Orphanet67 C0006845

Summaries for Chronic Mucocutaneous Candidiasis

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Disease Ontology:11 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to t-cell defects, has-agent candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

MalaCards based summary: Chronic Mucocutaneous Candidiasis, also known as candidiasis, chronic mucocutaneous, is related to alopecia and systemic lupus erythematosus, and has symptoms including scaling of skin lesions, thickening of nails and swollen periungal tissue. An important gene associated with Chronic Mucocutaneous Candidiasis is IL17F (Interleukin 17F), and among its related pathways are IL6-mediated signaling events and Immune response_IL-12 signaling pathway. The drugs itraconazole and fluconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, mucous membrane and nail due to t-cell defects, and related mouse phenotypes are integument and no phenotypic analysis.

Wikipedia:69 Chronic mucocutaneous candidiasis is an immune disorder of T cells. It is characterized by chronic... more...

Related Diseases for Chronic Mucocutaneous Candidiasis

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Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 252)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia29.9IL10, IL6, TNF
2systemic lupus erythematosus28.7IFNG, IL10, IL2RA, IL6, PTPN22, TNF
3immunodeficiency 31c, autosomal dominant11.6
4candidiasis, familial, 811.6
5candidiasis, familial, 2, autosomal recessive11.5
6candidiasis, familial, 6, autosomal dominant11.4
7candidiasis, familial, 4, autosomal recessive11.4
8candidiasis, familial, 5, autosomal recessive11.4
9candidiasis11.1
10chudley-mccullough syndrome10.9
11capillary malformations, congenital, 1, somatic, mosaic10.9
12rasmussen subacute encephalitis10.7IL17A, IL17F, IL22
13chronic polyneuropathy10.7IFNG, IL17A, STAT1
14nevus mucinosis10.6IL10, IL17A
15tetanus neonatorum10.6IFNG, IL10, IL17A
16progressive relapsing multiple sclerosis10.6IFNG, IL10, IL17A
17eye accommodation disease10.5IFNG, IL10, IL2RA
18cd3zeta deficiency10.5AIRE, IFNG, PTPN22
19chronic hiccups10.5IFNG, IL10, IL2RA
20autoimmune myocarditis10.5IL17A, IL2RA, STAT3
21laryngeal cancer, childhood10.5IL2RA, STAT3
22hypertensive encephalopathy10.5IFNG, IL10, IL17A
23idiopathic neutropenia10.4IFNG, IL10, IL6
24melioidosis10.4IFNG, IL10, IL6
25jejunal somatostatinoma10.3IFNG, IL10, IL6
26thymoma10.3
27autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.3
28smooth muscle tumor10.3IFNG, IL10, IL17A, STAT3
29motor peripheral neuropathy10.3IFNG, IL2RA
30dermatitis herpetiformis, familial10.3IFNG, IL6, PTPN22
31herpangina10.3IFNG, IL10, IL17F, IL6
32polyradiculoneuropathy10.2IL10, IL17A, IL2RA, IL6
33nervous system disease10.2IFNG, IL2RA, IL6, STAT1
34piepkorn karp hickok syndrome10.2IL10, TNF
35dermatophytosis10.2
36aneurysm10.2
376q terminal deletion syndrome10.2IL10, TNF
38esophagitis10.1
39hypothyroidism10.1
40histoplasmosis10.1
41lupus erythematosus10.1
42alopecia areata10.1
43benign adult familial myoclonic epilepsy10.1IL10, IL2RA, IL6, PTPN22
44atrichia with papular lesions10.1AIRE, IFNG, TNF
45predominantly cortical thymoma10.1IL10, IL6
46baetz-greenwalt syndrome10.1IFNG, TNF
47aplastic anemia10.0
48keratitis10.0
49hemolytic anemia10.0
50hepatitis10.0

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to chronic mucocutaneous candidiasis

Symptoms for Chronic Mucocutaneous Candidiasis

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Symptoms:

 11 52 (show all 33)
  • s
  • t
  • recurrent urinary tract infections
  • abnormality of the vagina
  • abnormality of the mouth
  • abnormality of the lip
  • abnormality of the eye
  • abnormality of vision
  • abnormality of dental enamel
  • hematuria
  • abnormality of the skin
  • hyperkeratosis
  • skin rash
  • pruritus
  • abnormality of the fingernails
  • seizures
  • abnormality of the nail
  • broad nail
  • hemoptysis
  • recurrent respiratory infections
  • abnormality of the immune system
  • recurrent infections
  • abnormality of the endocardium
  • abnormality of temperature regulation
  • abnormality of the toenails
  • feeding difficulties in infancy
  • erythema
  • hepatitis
  • cough
  • dyspareunia
  • cheilitis
  • papule
  • skin ulcer

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

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Drugs for Chronic Mucocutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Amphotericin BPhase 21171397-89-314956, 5280965
Synonyms:
12633-72-6
1397-89-3
30782-62-8
5-18-10-00525 (Beilstein Handbook Reference)
54482-28-9
8055-20-7
AB00513832
ABLC
AC1L1CN2
AC1L24V6
AC1L70KF
AC1L73U6
AC1NQXTD
AC1NTQ32
AC1NUQG4
AC1NY9JC
AC1O7GCZ
AC1O8FQV
AC1O8PFK
AI3-26528
AMPH-B
AMPH-b
Abelcet
Abelecet
AmBisome (TN)
Ambap1397-89-3
Ambisome
Amfotericina B
Amfotericina B [INN-Spanish]
Ampho-Moronal
Amphocin
Amphomoronal
Amphortericin B
Amphotec
Amphotec (TN)
Amphotericin
Amphotericin .BETA.
Amphotericin B
Amphotericin B (JP15/USP/INN)
Amphotericin B Cholesterol Dispersion
Amphotericin B Colloidal Dispersion
Amphotericin B [USAN:INN:JAN]
Amphotericin B, Lipid-based
Amphotericin B, Streptomyces sp.
Amphotericin-B
Amphotericine B
Amphotericine B [INN-French]
Amphotericinum
Amphotericinum B
Amphotericinum B [INN-Latin]
Amphotherizin
Amphotherizin [German]
Amphotéricine B
Amphozone
BIDD:GT0351
BPBio1_000374
BRN 0078342
BSPBio_000340
C-AmB
C06573
C47H73NO17
CCRIS 5963
CHEBI:2682
CHEMBL1200646
CHEMBL267345
CID10533925
CID10629638
CID10677275
CID14956
CID1972
 
CID352546
CID354192
CID5280965
CID5386092
CID5458486
CID5771695
CID6604295
CID6708817
CID6713692
CID9919339
D00203
DB00681
DivK1c_007045
EINECS 215-742-2
Fungilin
Fungisome
Fungisone
Fungizone
Fungizone (TN)
HMS1569A22
HSDB 3008
HSDB 3008 IAB
Halizon
I06-0257
KBio1_001989
KBio2_000551
KBio2_003119
KBio2_005687
KBioGR_002298
KBioSS_000551
LMPK06000002
LNS-AmB
LS-187721
LS-93
Liposomal Amphotericin B
Liposomal amphotericin b
MLS002702966
MolPort-006-392-260
Mysteclin-F
NCGC00014913
NCGC00090808-01
NCGC00098014-01
NCGC00179595-01
NCI527017
NCI60_004288
NCIStruc1_001042
NCIStruc2_000920
NKTR-024
NS 718
NSC 527017
NSC-527017
NSC527017
Prestwick0_000410
Prestwick1_000410
Prestwick2_000410
Prestwick3_000410
Prestwick_721
SMP1_000302
SMR001566780
SPBio_000715
SPBio_002279
ST50999656
SinuNase
SpecPlus_000949
Spectrum2_000818
Spectrum4_001779
Spectrum_000111
UNII-7XU7A7DROE
amophotericin B
amphotericin B liposomal
amphotericin b
2
MiconazolePhase 2357322916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
3
rituximabPhase 11611174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab

Interventional clinical trials:

idNameStatusNCT IDPhase
1CAMB/MAT2203 in Patients With Mucocutaneous CandidiasisRecruitingNCT02629419Phase 2
2Rituximab for Anti-cytokine Autoantibody-Associated DiseasesRecruitingNCT01842386Phase 1
3Studies of Disorders With Increased Susceptibility to Fungal InfectionsRecruitingNCT01222741

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS66/NDF-RT44:


Cochrane evidence based reviews: candidiasis, chronic mucocutaneous

Genetic Tests for Chronic Mucocutaneous Candidiasis

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Genetic tests related to Chronic Mucocutaneous Candidiasis:

id Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis25

Anatomical Context for Chronic Mucocutaneous Candidiasis

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MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

34
Skin, T cells, Eye, Neutrophil, Bone marrow, Monocytes, Lung

FMA organs/tissues related to Chronic Mucocutaneous Candidiasis:

17
Skin, Mucous membrane, Nail due to t-cell defects

Animal Models for Chronic Mucocutaneous Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

39 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6IFNG, IL10, IL17RA, IL6, STAT1, STAT3
2MP:00030128.3AIRE, IFNG, IL10, IL17A, IL17RA, IL23R
3MP:00053708.2AIRE, IFNG, IL10, IL6, PTPN22, STAT1
4MP:00053918.1AIRE, IFNG, IL10, IL6, STAT1, STAT3
5MP:00020068.0AIRE, IFNG, IL10, IL17RA, IL23R, IL6
6MP:00053907.4IFNG, IL10, IL17A, IL17F, IL17RB, IL6
7MP:00053796.7AIRE, HSP90AA1, IFNG, IL10, IL23R, IL6
8MP:00053886.6AIRE, CLEC7A, IFNG, IL10, IL17A, IL17F
9MP:00053846.5AIRE, HSP90AA1, IFNG, IL10, IL17RA, IL17RB
10MP:00107686.1AIRE, CLEC7A, HSP90AA1, IFNG, IL10, IL17A
11MP:00053766.0AIRE, CLEC7A, IFNG, IL10, IL17A, IL17RA
12MP:00053815.7AIRE, CLEC7A, IFNG, IL10, IL17A, IL17F
13MP:00053785.6AIRE, IFNG, IL10, IL17A, IL17F, IL17RB
14MP:00053975.6AIRE, CLEC7A, IFNG, IL10, IL17A, IL17F
15MP:00053875.0AIRE, CLEC7A, HSP90AA1, IFNG, IL10, IL17A

Publications for Chronic Mucocutaneous Candidiasis

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Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50)    (show all 256)
idTitleAuthorsYear
1
Chronic mucocutaneous candidiasis: characterization of a family with STAT-1 gain-of-function and development of an ex-vivo assay for Th17 deficiency of diagnostic utility. (26621323)
2016
2
Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. (26948078)
2016
3
Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion. (23791509)
2013
4
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. (22730530)
2012
5
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. (22403094)
2012
6
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. (21197459)
2011
7
Chronic mucocutaneous candidiasis, from bench to bedside. (20133219)
2010
8
Autosomal dominant chronic mucocutaneous candidiasis and primary hypothyroidism complicated by oesophageal carcinoma. (19778308)
2009
9
Chronic mucocutaneous candidiasis and oesophageal cancer. (17852718)
2008
10
Chronic mucocutaneous candidiasis with agammaglobulinaemia. (17567323)
2007
11
Chronic mucocutaneous candidiasis associated with malignant thymoma and systemic lupus erythematosus with hypergammaglobulinemia: a case report and literature review. (16903322)
2006
12
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
13
Chronic mucocutaneous candidiasis in a child. (16394492)
2005
14
Disseminated Candida tropicalis in a patient with chronic mucocutaneous candidiasis. (15352680)
2004
15
Chronic mucocutaneous candidiasis in a 6-year-old boy. (15221041)
2004
16
Polyglandular autoimmune syndrome type 1 without chronic mucocutaneous candidiasis in a 16 year-old male. (12585347)
2003
17
Characterization of the cellular immune function of patients with chronic mucocutaneous candidiasis. (11207655)
2001
18
What syndrome is this? Chronic mucocutaneous candidiasis. (11576415)
2001
19
Autoimmune hemolytic anemia in a patient with autosomal dominant chronic mucocutaneous candidiasis. (10943243)
2000
20
Pneumocystis carinii pneumonia in a 15-year-old with chronic mucocutaneous candidiasis. (10447335)
1999
21
Chronic mucocutaneous candidiasis with widespread dermatophyte infection: the trailing scale sign. (8646859)
1996
22
Chronic mucocutaneous candidiasis. (8077500)
1994
23
Fatal pulmonary nocardiosis in a patient with chronic mucocutaneous candidiasis. (8064079)
1994
24
Disseminated histoplasmosis in chronic mucocutaneous candidiasis. (8516028)
1993
25
Chronic mucocutaneous candidiasis. (2502409)
1989
26
The "yeast connection" meets chronic mucocutaneous candidiasis. (3951526)
1986
27
Chronic mucocutaneous candidiasis. (6317830)
1983
28
Impaired generation of helper T cells in a patient with chronic mucocutaneous candidiasis and malignant thymoma. (6221110)
1983
29
Scanning electron microscopy of oral lesions in chronic mucocutaneous candidiasis. (7001057)
1980
30
Symposium: Chronic mucocutaneous candidiasis. (552463)
1979
31
Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole. (434848)
1979
32
Topical clotrimazole treatment of chronic mucocutaneous candidiasis. (762637)
1979
33
Plasma thymic hormone activity in patients with chronic mucocutaneous candidiasis. (743805)
1978
34
Chronic mucocutaneous candidiasis. Immunologic evaluation and therapy. (844330)
1977
35
An immunological investigation of a family with chronic mucocutaneous candidiasis. (797672)
1976
36
Chronic mucocutaneous candidiasis, dermatophytosis and defective cellular immunity in monozygotic twins. (4134659)
1974
37
Chronic mucocutaneous candidiasis. (4470726)
1974
38
Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man. (4549559)
1974
39
Selective hypopituitarism. Impaired cell-mediated immunity and chronic mucocutaneous candidiasis. (4740720)
1973
40
Chronic mucocutaneous candidiasis: iron deficiency and the effects of iron therapy. (4733977)
1973
41
Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. (4571566)
1973
42
Chronic mucocutaneous candidiasis and alopecia areata. (4706468)
1973
43
Transfer factor in the treatment of a case of chronic mucocutaneous candidiasis. (4554089)
1972
44
Treatment of chronic mucocutaneous candidiasis with leucocytes from HL-A compatible sibling. (4109818)
1972
45
Prolonged oral treatment of chronic mucocutaneous candidiasis with Amphotericin B. (5120161)
1971
46
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4192497)
1970
47
Transfer of cellular hypersensitivity in chronic mucocutaneous candidiasis monitored in vivo and in vitro. (5523582)
1970
48
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4193722)
1970
49
Chronic mucocutaneous candidiasis. (5479318)
1970
50
Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities. Report of a syndrome of superficial candidiasis, absence of delayed hypersensitivity and aminoaciduria. (5822974)
1969

Variations for Chronic Mucocutaneous Candidiasis

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Expression for genes affiliated with Chronic Mucocutaneous Candidiasis

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Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for genes affiliated with Chronic Mucocutaneous Candidiasis

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Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idSuper pathwaysScoreTop Affiliating Genes
19.6IL6, STAT1, STAT3
2
Show member pathways
9.5IFNG, IL2RA, STAT3
39.5IFNG, IL2RA, STAT3
49.3IFNG, IL6, TNF
5
Show member pathways
9.3IL22, IL2RA, STAT1, STAT3
6
Show member pathways
9.3IFNG, IL2RA, STAT1, STAT3
7
Show member pathways
9.3IFNG, IL2RA, STAT1, STAT3
89.2IL2RA, IL6, STAT1, STAT3
99.2IFNG, STAT1, STAT3, TNF
109.1IL6, STAT1, STAT3, TNF
119.1IL6, STAT1, STAT3, TNF
129.1IFNG, IL17A, IL6, TNF
13
Show member pathways
9.1HSP90AA1, IL2RA, STAT1, STAT3
149.1HSP90AA1, IL6, STAT1, STAT3
15
Show member pathways
9.1IFNG, IL10, IL2RA, TNF
169.0IL10, IL6, STAT3, TNF
179.0HSP90AA1, IFNG, IL6, STAT1
189.0IFNG, IL10, IL6, TNF
199.0IFNG, IL10, IL6, TNF
209.0IFNG, IL10, IL6, TNF
219.0IFNG, IL10, IL6, TNF
229.0IL10, IL2RA, IL6, TNF
238.9IFNG, IL10, IL17RB, IL2RA
24
Show member pathways
8.9IFNG, IL10, STAT1, STAT3, TNF
258.8IFNG, IL10, IL17RA, IL6, TNF
268.8IFNG, IL6, STAT1, STAT3, TNF
278.8IL10, IL17A, IL22, IL6, TNF
288.7IFNG, IL10, IL2RA, IL6, TNF
298.6IFNG, IL10, IL2RA, IL6, STAT1, STAT3
308.6CLEC7A, IFNG, IL10, IL6, STAT1, TNF
31
Show member pathways
8.5IFNG, IL10, IL17A, IL6, STAT1, TNF
32
Show member pathways
8.5IL22, IL2RA, IL6, STAT1, STAT3, TNF
33
Show member pathways
8.5IFNG, IL10, IL6, STAT1, STAT3, TNF
34
Show member pathways
8.5IFNG, IL2RA, IL6, STAT1, STAT3, TNF
35
Show member pathways
8.4IL17A, IL17F, IL17RA, IL17RC, IL23R, IL6
36
Show member pathways
8.1IL17A, IL17F, IL17RA, IL17RB, IL17RC, IL6
37
Show member pathways
8.0IFNG, IL17A, IL17F, IL17RA, IL22, IL23R
38
Show member pathways
7.9IFNG, IL10, IL22, IL23R, IL2RA, IL6
39
Show member pathways
7.9IFNG, IL10, IL17A, IL17RC, IL22, IL2RA
40
Show member pathways
7.8IFNG, IL10, IL17A, IL23R, IL6, STAT1
417.8CLEC7A, IFNG, IL10, IL2RA, PTPN22, STAT1
42
Show member pathways
7.6IFNG, IL10, IL17A, IL17F, IL23R, IL6
437.5IFNG, IL10, IL17A, IL17RB, IL22, IL23R
44
Show member pathways
7.4IFNG, IL10, IL17A, IL17RC, IL22, IL2RA
45
Show member pathways
7.1IL10, IL17A, IL17RA, IL17RC, IL22, IL23R
46
Show member pathways
7.1IL10, IL17A, IL17RA, IL17RC, IL22, IL23R
47
Show member pathways
6.9HSP90AA1, IFNG, IL10, IL17A, IL17F, IL22
48
Show member pathways
6.6HSP90AA1, IL10, IL17A, IL17RA, IL17RC, IL22
49
Show member pathways
5.9HSP90AA1, IFNG, IL10, IL17A, IL17RA, IL17RB
50
Show member pathways
5.6CLEC7A, HSP90AA1, IFNG, IL17A, IL17F, IL17RA

GO Terms for genes affiliated with Chronic Mucocutaneous Candidiasis

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Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0IFNG, IL17A, IL2RA, IL6, TNF
2intracellularGO:00056228.4AIRE, HSP90AA1, IFNG, IL2RA, TNF, TRAF3IP2
3extracellular regionGO:00055767.2HSP90AA1, IFNG, IL17A, IL17F, IL17RA, IL17RB

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:007253710.8IL17A, IL17RA
2granulocyte chemotaxisGO:007162110.7IL17RA, IL17RC
3neutrophil apoptotic processGO:000178110.6IFNG, IL6
4positive regulation of interleukin-6 secretionGO:200077810.5IL17A, IL17F, IL17RC
5positive regulation of MHC class II biosynthetic processGO:004534810.5IFNG, IL10
6positive regulation of vitamin D biosynthetic processGO:006055710.4IFNG, TNF
7positive regulation of calcidiol 1-monooxygenase activityGO:006055910.4IFNG, TNF
8positive regulation of chemokine biosynthetic processGO:004508010.4IFNG, TNF
9receptor biosynthetic processGO:003280010.4IL10, TNF
10negative regulation of cytokine secretion involved in immune responseGO:000274010.4IL10, TNF
11positive regulation of interleukin-5 secretionGO:200066410.4IL17RA, IL17RB
12interleukin-6-mediated signaling pathwayGO:007010210.4IL6, STAT3
13positive regulation of interleukin-13 secretionGO:200066710.4IL17RA, IL17RB
14epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.3IL6, TNF
15positive regulation of interleukin-23 productionGO:003274710.3IFNG, IL17A, IL17RA
16positive regulation of cytokine production involved in inflammatory responseGO:190001710.3IL17A, IL17F, IL17RA, IL17RC
17defense response to fungusGO:005083210.2IL17A, IL17RA, IL17RC
18positive regulation of protein import into nucleus, translocationGO:003316010.2HSP90AA1, IL6
19negative regulation of lipid storageGO:001088810.2IL6, TNF
20response to salt stressGO:000965110.1HSP90AA1, TNF
21acute-phase responseGO:000695310.1IL22, IL6, STAT3
22response to cytokineGO:003409710.0IL6, STAT1, STAT3
23positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.0IL23R, IL6, STAT3
24positive regulation of JAK-STAT cascadeGO:004642710.0IL10, IL22, IL6
25positive regulation of smooth muscle cell proliferationGO:004866110.0IL6, STAT1, TNF
26negative regulation of growth of symbiont in hostGO:004413010.0IFNG, IL10, TNF
27cellular response to organic cyclic compoundGO:00714079.9STAT1, STAT3, TNF
28defense response to protozoanGO:00428329.9CLEC7A, IFNG, IL10, IL6
29response to glucocorticoidGO:00513849.6IL10, IL22, IL6, TNF
30positive regulation of osteoclast differentiationGO:00456729.6IFNG, IL17A, IL23R, TNF
31humoral immune responseGO:00069599.6AIRE, IFNG, IL6, TNF, TRAF3IP2
32cellular response to lipopolysaccharideGO:00712229.5IFNG, IL10, IL6, TNF
33cellular response to cytokine stimulusGO:00713459.4IL17RA, IL6, STAT1, STAT3
34positive regulation of T cell proliferationGO:00421029.4IFNG, IL23R, IL2RA, IL6
35cytokine-mediated signaling pathwayGO:00192219.2IL17RA, IL17RB, IL17RC, IL6, STAT3
36response to lipopolysaccharideGO:00324969.2IL10, IL23R, IL6, PTPN22
37positive regulation of nitric oxide biosynthetic processGO:00454299.2HSP90AA1, IFNG, IL6, TNF
38immune responseGO:00069559.2AIRE, IL10, IL17A, IL22, IL2RA
39positive regulation of gene expressionGO:00106288.8IFNG, IL6, PTPN22, STAT3, TNF
40positive regulation of transcription, DNA-templatedGO:00458938.6AIRE, IFNG, IL10, IL6, STAT1, STAT3
41response to drugGO:00424938.1HSP90AA1, IFNG, IL10, IL6, STAT1, STAT3
42inflammatory responseGO:00069548.1CLEC7A, IL10, IL17A, IL17F, IL22, IL23R
43positive regulation of transcription from RNA polymerase II promoterGO:00459447.8AIRE, IFNG, IL10, IL17A, IL17F, IL6

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CCR5 chemokine receptor bindingGO:003173010.6STAT1, STAT3
2interleukin-17 receptor activityGO:003036810.2IL17RA, IL17RB, IL17RC
3cytokine activityGO:00051258.9IFNG, IL10, IL17A, IL17F, IL22, IL6
4protein bindingGO:00055154.9AIRE, CLEC7A, HSP90AA1, IFNG, IL10, IL17A

Sources for Chronic Mucocutaneous Candidiasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet