MCID: CHR063
MIFTS: 58

Chronic Mucocutaneous Candidiasis malady

Skin diseases, Infectious diseases categories

Summaries for Chronic Mucocutaneous Candidiasis

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Sources:
9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Disease Ontology:9 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to t-cell defects, has-agent candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

MalaCards: Chronic Mucocutaneous Candidiasis, also known as mucocutaneous candidiasis, is related to keratitis and pneumonia, and has symptoms including scarring of the scalp, swollen periungal tissue and thickening of nails. An important gene associated with Chronic Mucocutaneous Candidiasis is IL17F (interleukin 17F), and among its related pathways are Immune response Antigen presentation by MHC class II and IL-9 Signaling Pathways. The drugs fluconazole and gentian violet and the compounds curcumin and ifn-alpha have been mentioned in the context of this disorder. Affiliated tissues include mucous membrane, nail due to t-cell defects and skin, and related mouse phenotypes are respiratory system and tumorigenesis.

Wikipedia:66 Chronic mucocutaneous candidiasis is an immune disorder of T cells. It is characterized by chronic... more...

Description from OMIM:48 613108,212050

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

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9Disease Ontology, 23GTR, 11DISEASES, 63UMLS, 46Novoseek, 41NCIt, 36MeSH, 48OMIM, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


Aliases & Descriptions:

chronic mucocutaneous candidiasis 9 23 11
mucocutaneous candidiasis 9 63
candidiasis, chronic mucocutaneous 63
candidiasis chronic mucocutaneous 46


External Ids:

Disease Ontology9 DOID:2058
NCIt41 C34444
SNOMED-CT59 234568006
MeSH36 D002178

Related Diseases for Chronic Mucocutaneous Candidiasis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to chronic mucocutaneous candidiasis

Symptoms for Chronic Mucocutaneous Candidiasis

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48OMIM, 9Disease Ontology
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Clinical features from OMIM:

613108,212050

Symptoms:

9
  • scarring of the scalp
  • swollen periungal tissue
  • thickening of nails
  • scaling of skin lesions

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Mucocutaneous Candidiasis

Drug clinical trials:

Search ClinicalTrials for Chronic Mucocutaneous Candidiasis

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Search CenterWatch for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Chronic Mucocutaneous Candidiasis

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23GTR
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Genetic tests related to Chronic Mucocutaneous Candidiasis:

id Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis23

Anatomical Context for Chronic Mucocutaneous Candidiasis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

34
T cells, Skin, Monocytes, Thymus, Bone marrow, Bone, B cells, Thyroid, Lung, Brain, Liver

FMA organs/tissues related to Chronic Mucocutaneous Candidiasis:

15
Mucous membrane, Nail due to t-cell defects, Skin

Animal Models for Chronic Mucocutaneous Candidiasis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4IL17A, IL22, IL17F, IL17RA
2MP:00020068.2STAT1, IL22, IL17RA
3MP:00053818.1IL17F, IL22, IL17A, STAT1
4MP:00030128.1IL17RA, IL22, IL17A, STAT1
5MP:00053768.0IL17RA, IL22, IL17A, STAT1
6MP:00053977.7IL17RA, IL17F, IL22, IL17A, STAT1
7MP:00053877.6STAT1, IL17A, IL22, IL17F, IL17RA

Publications for Chronic Mucocutaneous Candidiasis

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53PubMed
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Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. (22730530)
2012
2
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. (22403094)
2012
3
Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism. (22847544)
2012
4
Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis? (21988702)
2012
5
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. (21197459)
2011
6
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. (20123958)
2010
7
Autosomal dominant chronic mucocutaneous candidiasis and primary hypothyroidism complicated by oesophageal carcinoma. (19778308)
2009
8
Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED. (19037923)
2008
9
Altered, but not diminished specific T cell response in chronic mucocutaneous candidiasis patients. (17960405)
2007
10
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
11
Disseminated Candida tropicalis in a patient with chronic mucocutaneous candidiasis. (15352680)
2004
12
Polyglandular autoimmune syndrome type 1 without chronic mucocutaneous candidiasis in a 16 year-old male. (12585347)
2003
13
The syndrome of chronic mucocutaneous candidiasis with selective antibody deficiency. (12602677)
2003
14
Histopathologic and scanning electron microscope examination of the nail and hair in chronic mucocutaneous candidiasis. (12894108)
2003
15
Antigliadin antibodies associated with chronic mucocutaneous candidiasis. (12383098)
2002
16
Pneumocystis carinii pneumonia in a 15-year-old with chronic mucocutaneous candidiasis. (10447335)
1999
17
Haemophilus influenzae type D infection and IgG2 deficiency in a patient with chronic mucocutaneous candidiasis. (8203272)
1994
18
Chronic mucocutaneous candidiasis. (8077500)
1994
19
Fatal pulmonary nocardiosis in a patient with chronic mucocutaneous candidiasis. (8064079)
1994
20
Vascular nodules and plaques resembling chronic mucocutaneous candidiasis in a patient with a low interleukin 2 level. (8349866)
1993
21
Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis. (1986107)
1991
22
Chronic mucocutaneous candidiasis. Antibiotic and immunologic therapy. (3214089)
1988
23
KID syndrome (keratitis, ichthyosis, and deafness) and chronic mucocutaneous candidiasis: case report and review of the literature. (6390393)
1984
24
Immunological observations before and after successful treatment of chronic mucocutaneous candidiasis with ketoconazole and transfer factor. (6096150)
1984
25
Chronic mucocutaneous candidiasis. (6317830)
1983
26
Chronic mucocutaneous candidiasis and keratitis associated with malignant thymoma. (6838096)
1983
27
Impaired generation of helper T cells in a patient with chronic mucocutaneous candidiasis and malignant thymoma. (6221110)
1983
28
Treatment of chronic mucocutaneous candidiasis with 5-fluorocytosine. (6756218)
1982
29
Severe hepatitis associated with ketoconazole therapy for chronic mucocutaneous candidiasis. (6284445)
1982
30
Chronic mucocutaneous Candidiasis-endocrinopathies. (7318499)
1981
31
Chronic mucocutaneous candidiasis with candida granuloma treated with 5-fluorocytosine. (7227606)
1981
32
A serum-dependent defect of neutrophil function in chronic mucocutaneous candidiasis. (6995490)
1980
33
Chronic mucocutaneous candidiasis and disseminated histoplasmosis. (7358883)
1980
34
Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. (316285)
1979
35
Immunological investigation of patients with chronic mucocutaneous candidiasis. (399626)
1979
36
Symposium: Chronic mucocutaneous candidiasis. (552463)
1979
37
Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole. (434848)
1979
38
Plasma thymic hormone activity in patients with chronic mucocutaneous candidiasis. (743805)
1978
39
Clotrimazole: intermittent therapy in chronic mucocutaneous candidiasis. (842517)
1977
40
Chronic mucocutaneous candidiasis. Immunologic evaluation and therapy. (844330)
1977
41
Chronic mucocutaneous candidiasis, dermatophytosis and defective cellular immunity in monozygotic twins. (4134659)
1974
42
Chronic mucocutaneous candidiasis. (4470726)
1974
43
Selective hypopituitarism. Impaired cell-mediated immunity and chronic mucocutaneous candidiasis. (4740720)
1973
44
Chronic mucocutaneous candidiasis: iron deficiency and the effects of iron therapy. (4733977)
1973
45
Transfer factor in the treatment of a case of chronic mucocutaneous candidiasis. (4554089)
1972
46
Chronic mucocutaneous candidiasis, myositis, and thymoma. A new triad. (4564702)
1972
47
Treatment of chronic mucocutaneous candidiasis with leucocytes from HL-A compatible sibling. (4109818)
1972
48
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4192497)
1970
49
Transfer of cellular hypersensitivity in chronic mucocutaneous candidiasis monitored in vivo and in vitro. (5523582)
1970
50
Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities. Report of a syndrome of superficial candidiasis, absence of delayed hypersensitivity and aminoaciduria. (5822974)
1969

Variations for Chronic Mucocutaneous Candidiasis

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Expression for genes affiliated with Chronic Mucocutaneous Candidiasis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Mucocutaneous Candidiasis

Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for genes affiliated with Chronic Mucocutaneous Candidiasis

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Sources:
51PathCards, 61Thomson Reuters, 54QIAGEN, 55R&D Systems, 39NCBI BioSystems Database, 31KEGG, 56Reactome
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Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.1IL22, STAT1
2
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.1IL22, STAT1
3
Show member pathways
Type III interferon signaling39
9.1IL22, STAT1
4
Show member pathways
IL27-mediated signaling events39
9.1IL17A, STAT1
5
Show member pathways
8.9IL17A, IL17F, IL17RA
6
Show member pathways
8.9IL17RA, IL17F, IL17A
7
Show member pathways
8.8IL17A, IL22, IL17RA
8
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.7IL17F, IL17A, STAT1
9
Show member pathways
8.2STAT1, IL17A, IL22, IL17F
10
Show member pathways
7.5IL17RA, IL17F, IL22, IL17A, STAT1

Compounds for genes affiliated with Chronic Mucocutaneous Candidiasis

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46Novoseek
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Compounds related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1curcumin469.1IL17A, STAT1
2ifn-alpha469.0IL17A, STAT1
3endotoxin468.8IL17A, STAT1
4rantes468.5IL17RA, IL17A, STAT1

GO Terms for genes affiliated with Chronic Mucocutaneous Candidiasis

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17Gene Ontology
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Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.0IL17F, IL22, IL17A

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast activationGO:0725379.4IL17RA, IL17A
2positive regulation of interleukin-23 productionGO:0327479.3IL17RA, IL17A
3positive regulation of cytokine production involved in inflammatory responseGO:19000179.0IL17RA, IL17F, IL17A
4negative regulation of angiogenesisGO:0165258.9IL17F, STAT1
5inflammatory responseGO:0069548.9IL17A, IL22, IL17F
6positive regulation of transcription from RNA polymerase II promoterGO:0459448.7IL17F, IL17A, STAT1

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL17F, IL22, IL17A

Products for genes affiliated with Chronic Mucocutaneous Candidiasis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Chronic Mucocutaneous Candidiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet