MCID: CHR063
MIFTS: 66

Chronic Mucocutaneous Candidiasis

Categories: Rare diseases, Skin diseases, Blood diseases, Infectious diseases

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

MalaCards integrated aliases for Chronic Mucocutaneous Candidiasis:

Name: Chronic Mucocutaneous Candidiasis 12 49 55 36 28 14
Candidiasis, Chronic Mucocutaneous 41 69
Cmc 49 55
Candidiasis Chronic Mucocutaneous 51

Characteristics:

Orphanet epidemiological data:

55
chronic mucocutaneous candidiasis
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Childhood,Infancy;

Classifications:



Summaries for Chronic Mucocutaneous Candidiasis

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 1334Disease definitionChronic mucocutaneous candidosis (CMC) refers to a group of heterogenous disorders characterized by persistent, debilitating and/or recurrent infections of the skin, nails, and mucus membranes, mainly with the fungal pathogen Candida albicans.Visit the Orphanet disease page for more resources. Last updated: 10/21/2014

MalaCards based summary : Chronic Mucocutaneous Candidiasis, also known as candidiasis, chronic mucocutaneous, is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity and autoimmune polyendocrine syndrome, and has symptoms including scaling of skin lesions, thickening of nails and swollen periungal tissue. An important gene associated with Chronic Mucocutaneous Candidiasis is IL17F (Interleukin 17F), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Phagosome. The drugs Miconazole and Antifungal Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, mucous membrane and nail due to t-cell defects, and related phenotypes are immune system and hematopoietic system

Disease Ontology : 12 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to T-cell defects, has-agent Candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

Wikipedia : 72 Chronic mucocutaneous candidiasis is an immune disorder of T cells, it is characterized by chronic... more...

Related Diseases for Chronic Mucocutaneous Candidiasis

Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.1 AIRE IFNG IL10 IL17A
2 autoimmune polyendocrine syndrome 30.7 AIRE IL17A IL22
3 alopecia areata 30.6 AIRE IFNG IL2RA
4 meningitis 30.3 IFNG IL10 IL6
5 myasthenia gravis 30.2 AIRE IFNG IL10
6 candidiasis 29.5 AIRE CLEC7A HSP90AA1 IFNG IL10 IL17A
7 systemic lupus erythematosus 29.0 CD40 CSF1 IFNG IL10 IL17A IL2RA
8 familial candidiasis 12.1
9 candidiasis, familial, 4 11.8
10 candidiasis, familial, 2 11.8
11 immunodeficiency 51 11.8
12 immunodeficiency 31c 11.8
13 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 11.6
14 candidiasis, familial, 1 11.3
15 candidiasis, familial, 6 11.2
16 candidiasis, familial, 8 11.1
17 capillary malformations, congenital 11.1
18 chudley-mccullough syndrome 11.1
19 acute generalized exanthematous pustulosis 10.5 IL17A IL17F IL22
20 nasopharyngitis 10.5 IL17A IL17F IL17RA
21 nasopharyngeal disease 10.4 IL17A IL17F IL17RA
22 polyradiculoneuropathy 10.4 IFNG IL10 IL17A
23 central nervous system vasculitis 10.4 IFNG IL17A IL6
24 hyperlucent lung 10.4 IFNG IL10 IL2RA
25 mumps 10.4 IFNG IL2RA STAT1
26 mixed lacrimal gland cancer 10.4 IL6 STAT3
27 neurosyphilis 10.4 IL10 IL17A
28 chronic graft versus host disease 10.4 IFNG IL10 IL2RA
29 transverse myelitis 10.4 IL10 IL17A IL6
30 eales disease 10.4 IFNG IL10 IL6
31 hemorrhagic fever 10.4 IFNG IL10 IL6
32 extrinsic cardiomyopathy 10.4 IL10 IL17A IL6
33 acute graft versus host disease 10.4 IFNG IL10 IL2RA
34 plasmodium vivax malaria 10.3 IFNG IL10 IL6
35 autoimmune enteropathy 10.3 IL17A IL2RA STAT3
36 large granular lymphocyte leukemia 10.3 IL2RA STAT3
37 vogt-koyanagi-harada disease 10.3 IL10 IL17A IL2RA
38 cutaneous candidiasis 10.3 IL17A IL2RA
39 mixed connective tissue disease 10.3 IFNG IL10 IL6
40 melioidosis 10.3 IFNG IL10 IL6
41 eosinophilic fasciitis 10.3 IFNG IL5
42 human immunodeficiency virus infectious disease 10.3 IFNG IL10 IL6
43 parasitic protozoa infectious disease 10.3 IFNG IL10 IL6
44 thymoma, familial 10.3
45 thymoma 10.3
46 alcoholic hepatitis 10.3 IL10 IL22 IL6
47 osteomyelitis 10.3 IFNG IL10 IL6
48 langerhans cell histiocytosis 10.3 CSF1 IFNG IL17A
49 idiopathic neutropenia 10.3 IL10 IL2RA IL6
50 autoimmune disease of endocrine system 10.3 AIRE CD40 IFNG

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to Chronic Mucocutaneous Candidiasis

Symptoms & Phenotypes for Chronic Mucocutaneous Candidiasis

Symptoms:

12
  • scaling of skin lesions
  • thickening of nails
  • swollen periungal tissue
  • scarring of the scalp

Human phenotypes related to Chronic Mucocutaneous Candidiasis:

55 31 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent urinary tract infections 55 31 occasional (7.5%) Occasional (29-5%) HP:0000010
2 abnormality of the vagina 55 31 frequent (33%) Frequent (79-30%) HP:0000142
3 abnormality of vision 55 31 occasional (7.5%) Occasional (29-5%) HP:0000504
4 abnormality of dental enamel 55 31 occasional (7.5%) Occasional (29-5%) HP:0000682
5 hematuria 55 31 occasional (7.5%) Occasional (29-5%) HP:0000790
6 hyperkeratosis 55 31 hallmark (90%) Very frequent (99-80%) HP:0000962
7 skin rash 55 31 hallmark (90%) Very frequent (99-80%) HP:0000988
8 pruritus 55 31 occasional (7.5%) Occasional (29-5%) HP:0000989
9 abnormality of the fingernails 55 31 hallmark (90%) Very frequent (99-80%) HP:0001231
10 seizures 55 31 occasional (7.5%) Occasional (29-5%) HP:0001250
11 broad nail 55 31 hallmark (90%) Very frequent (99-80%) HP:0001821
12 hemoptysis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002105
13 recurrent respiratory infections 55 31 occasional (7.5%) Occasional (29-5%) HP:0002205
14 abnormality of temperature regulation 55 31 occasional (7.5%) Occasional (29-5%) HP:0004370
15 feeding difficulties in infancy 55 31 occasional (7.5%) Occasional (29-5%) HP:0008872
16 erythema 55 31 hallmark (90%) Very frequent (99-80%) HP:0010783
17 hepatitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012115
18 cough 55 31 occasional (7.5%) Occasional (29-5%) HP:0012735
19 dyspareunia 55 31 frequent (33%) Frequent (79-30%) HP:0030016
20 cheilitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0100825
21 papule 55 31 frequent (33%) Frequent (79-30%) HP:0200034
22 skin ulcer 55 31 hallmark (90%) Very frequent (99-80%) HP:0200042
23 abnormality of the mouth 55 Very frequent (99-80%)
24 abnormality of the lip 55 Very frequent (99-80%)
25 abnormality of the eye 55 Occasional (29-5%)
26 abnormality of the skin 55 Very frequent (99-80%)
27 abnormality of the nail 55 Very frequent (99-80%)
28 abnormality of the immune system 55 Very frequent (99-80%)
29 recurrent infections 55 Very frequent (99-80%)
30 abnormality of the endocardium 55 Occasional (29-5%)
31 abnormality of the toenails 55 Very frequent (99-80%)
32 abnormal endocardium morphology 31 occasional (7.5%) HP:0004306
33 abnormal toenail morphology 31 hallmark (90%) HP:0008388

MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.45 IFNG CLEC7A IL2RA CSF1 STAT1 AIRE
2 hematopoietic system MP:0005397 10.44 IFNG CLEC7A IL2RA CSF1 STAT1 AIRE
3 growth/size/body region MP:0005378 10.4 IL6 IL23R IFNG IL2RA CSF1 STAT1
4 homeostasis/metabolism MP:0005376 10.4 CD40 IL23R IFNG CLEC7A IL2RA CSF1
5 digestive/alimentary MP:0005381 10.39 IFNG CLEC7A IL2RA STAT1 AIRE IL5
6 endocrine/exocrine gland MP:0005379 10.35 IL23R IFNG IL2RA CSF1 STAT1 AIRE
7 mortality/aging MP:0010768 10.22 IL6 CLEC7A IL2RA CSF1 STAT1 AIRE
8 craniofacial MP:0005382 10.16 IFNG CSF1 HSP90AA1 STAT3 IL17A TRAF3IP2
9 integument MP:0010771 10.06 IL6 STAT1 CSF1 IL17RA IL10 STAT3
10 liver/biliary system MP:0005370 10.03 IL6 CSF1 STAT1 IL5 AIRE IL10
11 neoplasm MP:0002006 10.02 IL6 IL23R IFNG STAT1 AIRE IL5
12 respiratory system MP:0005388 10 IFNG CLEC7A IL2RA CSF1 AIRE IL5
13 no phenotypic analysis MP:0003012 9.92 IL23R CSF1 STAT1 AIRE IL17RA IL10
14 reproductive system MP:0005389 9.91 HSP90AA1 IL6 CSF1 IL5 AIRE IL10
15 skeleton MP:0005390 9.7 CD40 IL6 IFNG CSF1 STAT1 HSP90AA1
16 vision/eye MP:0005391 9.28 IL6 IFNG IL2RA CSF1 STAT1 AIRE

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

Drugs for Chronic Mucocutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
2 Antifungal Agents Phase 3,Phase 2
3
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Antiparasitic Agents Phase 2
7 Antiprotozoal Agents Phase 2
8 Autoantibodies Phase 2,Phase 1
9 Liposomal amphotericin B Phase 2
10
rituximab Approved Phase 1 174722-31-7 10201696
11 Antibodies Phase 1
12 Antibodies, Monoclonal Phase 1
13 Antirheumatic Agents Phase 1
14 Immunoglobulins Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open-Label Study to Evaluate Efficacy and Safety of SCY-078 in Patients With Refractory or Intolerant Fungal Diseases Recruiting NCT03059992 Phase 3 SCY-078
2 CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis Recruiting NCT02629419 Phase 2 Amphotericin B
3 Rituximab for Anti-cytokine Autoantibody-Associated Diseases Recruiting NCT01842386 Phase 1 Rituximab/Rituxan
4 Studies of Disorders With Increased Susceptibility to Fungal Infections Recruiting NCT01222741

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: candidiasis, chronic mucocutaneous

Genetic Tests for Chronic Mucocutaneous Candidiasis

Genetic tests related to Chronic Mucocutaneous Candidiasis:

# Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis 28

Anatomical Context for Chronic Mucocutaneous Candidiasis

The Foundational Model of Anatomy Ontology organs/tissues related to Chronic Mucocutaneous Candidiasis:

18
Skin, Mucous Membrane, Nail Due To T-Cell Defects

MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

38
Skin, T Cells, Eye, Neutrophil, Bone Marrow, Monocytes, Lung

Publications for Chronic Mucocutaneous Candidiasis

Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50) (show all 266)
# Title Authors Year
1
New and recurrent STAT1 mutations in seven Chinese patients with chronic mucocutaneous candidiasis. ( 27808400 )
2017
2
Chronic Mucocutaneous Candidiasis. ( 28065688 )
2017
3
A Novel Heterozygous Mutation in the STAT1 SH2 Domain Causes Chronic Mucocutaneous Candidiasis, Atypically Diverse Infections, Autoimmunity, and Impaired Cytokine Regulation. ( 28348565 )
2017
4
Disseminated Tuberculosis and Chronic Mucocutaneous Candidiasis in a Patient with a Gain-of-Function Mutation in Signal Transduction and Activator of Transcription 1. ( 29270166 )
2017
5
Chronic mucocutaneous candidiasis: what can we conclude about IL-17 antagonism? ( 29076381 )
2017
6
CMCD: Chronic Mucocutaneous Candidiasis Disease. ( 28603201 )
2017
7
A gain-of-function mutation of STAT1: A novel genetic factor contributing to chronic mucocutaneous candidiasis. ( 28597685 )
2017
8
Gain-of-Function Mutations in<i>STAT1</i>: A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies. ( 29259832 )
2017
9
Vessel wall MRI revealing inflammation on brain aneurysm associated to chronic mucocutaneous candidiasis. ( 28992729 )
2017
10
Treatment options for chronic mucocutaneous candidiasis. ( 27161991 )
2016
11
Clinical heterogeneity of dominant chronic mucocutaneous candidiasis disease: presenting as treatment-resistant candidiasis and chronic lung disease. ( 26732859 )
2016
12
Th2 and Th9 responses in patients with chronic mucocutaneous candidiasis and hyper-IgE syndrome. ( 27474157 )
2016
13
Chronic mucocutaneous candidiasis presenting as Candida endophthalmitis. ( 27085277 )
2016
14
The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1. ( 26604104 )
2016
15
Chronic mucocutaneous candidiasis disease associated with inborn errors of IL-17 immunity. ( 28090315 )
2016
16
Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. ( 26948078 )
2016
17
Ruxolitinib Induces Interleukin 17 and Ameliorates Chronic Mucocutaneous Candidiasis Caused by STAT1 Gain-of-Function Mutation. ( 26787170 )
2016
18
Clonal Strain Persistence of Candida albicans Isolates from Chronic Mucocutaneous Candidiasis Patients. ( 26849050 )
2016
19
Chronic mucocutaneous candidiasis: characterization of a family with STAT-1 gain-of-function and development of an ex-vivo assay for Th17 deficiency of diagnostic utility. ( 26621323 )
2016
20
Clinical and immunological data of nine patients with chronic mucocutaneous candidiasis disease. ( 26981552 )
2016
21
Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). ( 26255980 )
2015
22
Recurrent inflammatory aortic aneurysms in chronic mucocutaneous candidiasis with a gain-of-function STAT1 mutation. ( 26080282 )
2015
23
Immunotherapy with G-CSF in patients with chronic mucocutaneous candidiasis. ( 25999307 )
2015
24
A novel gain-of-function STAT1 mutation resulting in basal phosphorylation of STAT1 and increased distal IFN-I^-mediated responses in chronic mucocutaneous candidiasis. ( 26514428 )
2015
25
Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. ( 25918342 )
2015
26
A STAT1-gain-of-function mutation causing Th17 deficiency with chronic mucocutaneous candidiasis, psoriasiform hyperkeratosis and dermatophytosis. ( 26494717 )
2015
27
Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation. ( 25662309 )
2015
28
Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): Chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding. ( 25042743 )
2014
29
Two Novel Gain-of-Function Mutations of STAT1 Responsible for Chronic Mucocutaneous Candidiasis Disease: Impaired Production of IL-17A and IL-22, and the Presence of Anti-IL-17F Autoantibody. ( 25288569 )
2014
30
Chronic mucocutaneous candidiasis: a case with exuberant cutaneous horns in nipples. ( 25054753 )
2014
31
Altered immune responses in patients with chronic mucocutaneous candidiasis. ( 24582143 )
2014
32
Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis. ( 24343863 )
2013
33
IL-17 T Cells' Defective Differentiation In Vitro Despite Normal Range Ex Vivo in Chronic Mucocutaneous Candidiasis Due to STAT1 Mutation. ( 24335902 )
2013
34
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis. ( 24240291 )
2013
35
Autosomal dominant cases of chronic mucocutaneous candidiasis segregates with mutations of signal transducer and activator of transcription 1, but not of Toll-like receptor 3. ( 23541088 )
2013
36
Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion. ( 23791509 )
2013
37
Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1. ( 23122533 )
2013
38
New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe. ( 23709754 )
2013
39
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. ( 24120361 )
2013
40
Fungal granuloma of the brain in a case of chronic mucocutaneous candidiasis. ( 22724885 )
2012
41
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. ( 22403094 )
2012
42
Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. ( 23026768 )
2012
43
Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism. ( 22847544 )
2012
44
Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis? ( 21988702 )
2012
45
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. ( 22730530 )
2012
46
Invariant natural killer T (iNKT) cell deficiency in chronic mucocutaneous candidiasis--a consequence or a cause? ( 20923687 )
2011
47
Defects in interleukin-17 immunity in the pathogenesis of chronic mucocutaneous candidiasis. ( 21766202 )
2011
48
STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis. ( 22195034 )
2011
49
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. ( 21197459 )
2011
50
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. ( 21727188 )
2011

Variations for Chronic Mucocutaneous Candidiasis

Expression for Chronic Mucocutaneous Candidiasis

Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for Chronic Mucocutaneous Candidiasis

Pathways related to Chronic Mucocutaneous Candidiasis according to KEGG:

36
# Name Kegg Source Accession
1 NOD-like receptor signaling pathway hsa04621
2 Phagosome hsa04145
3 Cytokine-cytokine receptor interaction hsa04060
4 Chemokine signaling pathway hsa04062
5 Toll-like receptor signaling pathway hsa04620
6 Jak-STAT signaling pathway hsa04630

Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CD40 CLEC7A CSF1 HSP90AA1 IFNG IL10
2
Show member pathways
13.89 CD40 CSF1 IL10 IL17A IL17RA IL17RC
3
Show member pathways
13.67 CD40 CSF1 HSP90AA1 IFNG IL10 IL17A
4
Show member pathways
13.6 IFNG IL10 IL17A IL17RC IL22 IL2RA
5
Show member pathways
13.47 CD40 CSF1 HSP90AA1 IL10 IL17A IL17RA
6
Show member pathways
13.39 CD40 CSF1 IL10 IL17A IL17RA IL17RC
7
Show member pathways
13.3 CD40 CSF1 HSP90AA1 IFNG IL10 IL17A
8
Show member pathways
12.96 CD40 HSP90AA1 IFNG IL10 IL17A IL22
9 12.95 HSP90AA1 IFNG IL23R IL2RA IL5 IL6
10
Show member pathways
12.82 IFNG IL2RA IL6 STAT1 STAT3
11
Show member pathways
12.81 IL22 IL2RA IL6 STAT1 STAT3
12
Show member pathways
12.71 CD40 IFNG STAT1 STAT3 TRAF3IP2
13
Show member pathways
12.7 IFNG IL10 IL17A IL17F IL23R IL6
14 12.65 IFNG IL10 IL17A IL2RA STAT1 STAT3
15
Show member pathways
12.59 CD40 IFNG IL10 IL6 STAT1
16
Show member pathways
12.49 IFNG IL10 IL17A IL5 IL6
17
Show member pathways
12.47 HSP90AA1 IFNG IL10 IL17A IL17F IL22
18
Show member pathways
12.44 IFNG IL10 IL22 IL23R IL2RA IL5
19
Show member pathways
12.34 IFNG IL6 STAT1 STAT3
20 12.34 CD40 IFNG IL10 STAT3
21
Show member pathways
12.33 CD40 IFNG IL10 STAT1 STAT3
22 12.31 CLEC7A IFNG IL10 IL6 STAT1
23
Show member pathways
12.29 IFNG IL10 IL17A IL5 IL6 STAT1
24
Show member pathways
12.27 HSP90AA1 IFNG STAT1 STAT3
25 12.23 IFNG IL6 STAT1 STAT3
26
Show member pathways
12.13 IFNG IL2RA STAT1 STAT3
27
Show member pathways
12.13 HSP90AA1 IL2RA IL5 STAT1 STAT3
28 12.13 CSF1 IFNG IL10 IL2RA IL5 IL6
29 12.12 HSP90AA1 IL10 IL17A IL17F IL23R IL6
30
Show member pathways
12.07 IFNG IL10 IL17A IL23R IL6 STAT1
31
Show member pathways
12.04 IFNG IL2RA STAT1 STAT3
32
Show member pathways
12.03 HSP90AA1 IFNG IL17A IL17F IL17RA IL17RB
33 11.99 IFNG IL10 IL23R IL2RA IL6 STAT1
34 11.96 CSF1 IL2RA IL5 IL6
35 11.94 HSP90AA1 IFNG IL5 IL6 STAT1
36
Show member pathways
11.94 IL17A IL17F IL17RA IL17RC IL23R IL6
37 11.92 CSF1 IFNG IL17A IL6
38 11.9 IFNG IL10 IL6
39
Show member pathways
11.89 IFNG STAT1 STAT3
40 11.88 CSF1 IFNG IL10 IL17RA IL6
41
Show member pathways
11.85 IL6 STAT1 STAT3
42 11.83 IFNG IL10 IL17A IL17RB IL22 IL23R
43 11.82 CD40 IL10 IL2RA IL5 IL6
44
Show member pathways
11.79 IFNG IL2RA IL5
45
Show member pathways
11.66 IL6 STAT1 STAT3
46 11.66 IFNG STAT1 STAT3
47 11.64 CSF1 IL10 IL6 STAT3
48 11.64 CD40 IFNG IL10 IL6
49 11.64 IFNG IL10 IL17RB IL2RA IL5
50 11.62 CD40 IL10 STAT3

GO Terms for Chronic Mucocutaneous Candidiasis

Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CD40 CSF1 IFNG IL10 IL17A IL17F
2 extracellular region GO:0005576 9.4 CD40 CSF1 HSP90AA1 IFNG IL10 IL17A

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.93 CD40 IFNG IL6 STAT1
2 regulation of receptor activity GO:0010469 9.92 CSF1 IFNG IL10 IL17A IL17F IL22
3 cytokine-mediated signaling pathway GO:0019221 9.85 IL17RA IL17RB IL17RC IL5 IL6 STAT3
4 response to glucocorticoid GO:0051384 9.82 IL10 IL22 IL6
5 positive regulation of T cell proliferation GO:0042102 9.81 IL23R IL2RA IL6
6 humoral immune response GO:0006959 9.8 AIRE IFNG IL6 TRAF3IP2
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 CD40 IFNG IL23R IL6 STAT3
8 acute-phase response GO:0006953 9.77 IL22 IL6 STAT3
9 defense response to fungus GO:0050832 9.75 IL17A IL17RA IL17RC
10 cellular response to cytokine stimulus GO:0071345 9.74 IL17RA STAT1 STAT3
11 positive regulation of defense response to virus by host GO:0002230 9.73 IL23R STAT1 TRAF3IP2
12 positive regulation of osteoclast differentiation GO:0045672 9.73 CSF1 IFNG IL17A IL23R
13 positive regulation of interleukin-12 production GO:0032735 9.72 CD40 IFNG IL23R
14 positive regulation of interleukin-6 secretion GO:2000778 9.7 IL17A IL17F IL17RC
15 defense response to protozoan GO:0042832 9.69 CD40 CLEC7A IL10
16 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.66 IFNG STAT1
17 positive regulation of immunoglobulin secretion GO:0051024 9.65 IL5 IL6
18 interleukin-6-mediated signaling pathway GO:0070102 9.65 IL6 STAT3
19 positive regulation of interleukin-23 production GO:0032747 9.65 IFNG IL17A IL17RA
20 interleukin-12-mediated signaling pathway GO:0035722 9.65 IFNG IL10 IL23R STAT1 STAT3
21 T-helper 17 cell lineage commitment GO:0072540 9.63 IL6 STAT3
22 positive regulation of interleukin-13 secretion GO:2000667 9.62 IL17RA IL17RB
23 positive regulation of interleukin-5 secretion GO:2000664 9.62 IL17RA IL17RB
24 granulocyte chemotaxis GO:0071621 9.61 IL17RA IL17RC
25 fibroblast activation GO:0072537 9.58 IL17A IL17RA
26 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.46 IL17A IL17F IL17RA IL17RC
27 inflammatory response GO:0006954 9.4 CD40 CLEC7A CSF1 IL10 IL17A IL17F
28 cellular response to interleukin-17 GO:0097398 9.35 IL17A IL17F IL17RA IL17RB IL17RC
29 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 AIRE CD40 IL10 IL17A IL17F IL6
30 positive regulation of transcription, DNA-templated GO:0045893 10.08 AIRE IL10 IL5 IL6 STAT1 STAT3
31 positive regulation of cell proliferation GO:0008284 10.07 CSF1 IFNG IL5 IL6 STAT1 STAT3
32 immune response GO:0006955 10.06 AIRE CD40 IFNG IL10 IL17A IL2RA
33 immune system process GO:0002376 10.05 CD40 CLEC7A CSF1 IL23R IL2RA

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 CSF1 IL10 IL5 IL6
2 CCR5 chemokine receptor binding GO:0031730 9.32 STAT1 STAT3
3 cytokine activity GO:0005125 9.23 CSF1 IFNG IL10 IL17A IL17F IL22
4 interleukin-17 receptor activity GO:0030368 9.13 IL17RA IL17RB IL17RC
5 protein binding GO:0005515 10.11 AIRE CD40 CLEC7A CSF1 HSP90AA1 IFNG

Sources for Chronic Mucocutaneous Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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