MCID: CHR063
MIFTS: 61

Chronic Mucocutaneous Candidiasis

Categories: Rare diseases, Skin diseases, Blood diseases, Infectious diseases

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

MalaCards integrated aliases for Chronic Mucocutaneous Candidiasis:

Name: Chronic Mucocutaneous Candidiasis 12 50 56 29 14
Candidiasis, Chronic Mucocutaneous 42 69
Cmc 50 56
Candidiasis Chronic Mucocutaneous 52

Characteristics:

Orphanet epidemiological data:

56
chronic mucocutaneous candidiasis
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Childhood,Infancy;

Classifications:



Summaries for Chronic Mucocutaneous Candidiasis

NIH Rare Diseases : 50 the following summary is from orphanet, a european reference portal for information on rare diseases and orphan drugs.orpha number: 1334disease definitionchronic mucocutaneous candidosis (cmc) refers to a group of heterogenous disorders characterized by persistent, debilitating and/or recurrent infections of the skin, nails, and mucus membranes, mainly with the fungal pathogen candida albicans.visit the orphanet disease page for more resources. last updated: 10/21/2014

MalaCards based summary : Chronic Mucocutaneous Candidiasis, also known as candidiasis, chronic mucocutaneous, is related to alopecia and lymphoma, and has symptoms including recurrent respiratory infections, recurrent urinary tract infections and seizures. An important gene associated with Chronic Mucocutaneous Candidiasis is IL17F (Interleukin 17F), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Miconazole and Antifungal Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and eye, and related phenotypes are digestive/alimentary and immune system

Disease Ontology : 12 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to T-cell defects, has-agent Candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

Wikipedia : 72 Chronic mucocutaneous candidiasis is an immune disorder of T cells, it is characterized by chronic... more...

Related Diseases for Chronic Mucocutaneous Candidiasis

Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
id Related Disease Score Top Affiliating Genes
1 alopecia 30.8 IL10 IL22 IL6
2 lymphoma 29.3 AIRE IFNG IL10 IL17A IL4 IL6
3 systemic lupus erythematosus 28.7 IFNG IL10 IL17A IL18 IL2RA IL4
4 familial candidiasis 11.7
5 immunodeficiency 51 11.7
6 immunodeficiency 31c, autosomal dominant 11.7
7 candidiasis, familial, 8 11.7
8 candidiasis, familial, 4, autosomal recessive 11.3
9 candidiasis, familial, 2, autosomal recessive 11.3
10 candidiasis, familial, 6, autosomal dominant 11.3
11 autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia 11.2
12 familial candidiasis 5 11.1
13 candidiasis 11.0
14 neonatal marfan syndrome 10.8 IL17A IL17F IL22
15 acute necrotizing encephalitis 10.8 IFNG IL17A STAT1
16 phaeohyphomycosis 10.7 AIRE IL17A IL22
17 neutrophil-specific granule deficiency 10.7 IL10 IL17A
18 atrichia with papular lesions 10.7 AIRE IFNG IL2RA
19 myoclonic astatic epilepsy 10.7 IFNG IL4
20 graft-versus-host disease, protection against 10.6 IFNG IL10 IL2RA
21 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.6 IFNG IL10 IL2RA
22 intestinal disaccharidase deficiency 10.6 AIRE IFNG IL2RA
23 tricho onychic dysplasia 10.6 IL10 IL17A IL6
24 myofascial pain syndrome 10.6 IL10 IL17A IL6
25 bursitis 10.6 IL6 STAT3
26 acute ackee fruit intoxication 10.6 IL10 IL4
27 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.6 IFNG IL10 IL6
28 hepadnavirus infection 10.6 IFNG IL10 IL6
29 conduct disorder 10.5 IFNG IL10 IL6
30 laryngeal papillomatosis 10.5 IL2RA STAT3
31 extrahepatic bile duct adenocarcinoma 10.5 IFNG IL10 IL6
32 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.5 IL17A IL2RA
33 autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency 10.5 IL17A IL2RA STAT3
34 combined cellular and humoral immune defects with granulomas 10.5 AIRE IFNG IL10 IL17A
35 heart sarcoma 10.5 IFNG IL10 IL6
36 gastric ulcer 10.5 IFNG IL10 IL6
37 iida kannari syndrome 10.5 IL10 IL2RA IL6
38 carcinoma arising in nasal papillomatosis 10.5 IL10 IL2RA IL6
39 keratomalacia 10.5 IFNG IL10 IL6
40 thelaziasis 10.4 IFNG IL10 IL4
41 left bundle branch hemiblock 10.4 IFNG IL10 IL2RA STAT1
42 scabies 10.4 IFNG IL10 IL6
43 centronuclear myopathy 5 10.4 IFNG IL10 IL4
44 respiratory system disease 10.4 IFNG IL10 IL2RA
45 oropharyngeal cancer, childhood 10.4 IFNG IL10 IL4
46 dentinogenesis imperfecta 10.4 IFNG IL10 IL6 STAT1
47 spindle cell hemangioma 10.4 IFNG IL10 IL4
48 disease of mental health 10.4 IFNG IL10 IL17A IL6
49 cornea cancer 10.4 IFNG IL10 IL17A IL6
50 burn scar 10.4 IFNG IL10 IL17A IL6

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to Chronic Mucocutaneous Candidiasis

Symptoms & Phenotypes for Chronic Mucocutaneous Candidiasis

Human phenotypes related to Chronic Mucocutaneous Candidiasis:

56 32 (show all 31)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent respiratory infections 56 32 occasional (7.5%) Occasional (29-5%) HP:0002205
2 recurrent urinary tract infections 56 32 occasional (7.5%) Occasional (29-5%) HP:0000010
3 seizures 56 32 occasional (7.5%) Occasional (29-5%) HP:0001250
4 hematuria 56 32 occasional (7.5%) Occasional (29-5%) HP:0000790
5 hyperkeratosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0000962
6 cough 56 32 occasional (7.5%) Occasional (29-5%) HP:0012735
7 feeding difficulties in infancy 56 32 occasional (7.5%) Occasional (29-5%) HP:0008872
8 pruritus 56 32 occasional (7.5%) Occasional (29-5%) HP:0000989
9 hemoptysis 56 32 occasional (7.5%) Occasional (29-5%) HP:0002105
10 skin rash 56 32 hallmark (90%) Very frequent (99-80%) HP:0000988
11 erythema 56 32 hallmark (90%) Very frequent (99-80%) HP:0010783
12 abnormality of vision 56 32 occasional (7.5%) Occasional (29-5%) HP:0000504
13 hepatitis 56 32 occasional (7.5%) Occasional (29-5%) HP:0012115
14 abnormality of the fingernails 56 32 hallmark (90%) Very frequent (99-80%) HP:0001231
15 abnormality of temperature regulation 56 32 occasional (7.5%) Occasional (29-5%) HP:0004370
16 skin ulcer 56 32 hallmark (90%) Very frequent (99-80%) HP:0200042
17 abnormality of the endocardium 56 32 occasional (7.5%) Occasional (29-5%) HP:0004306
18 abnormality of dental enamel 56 32 occasional (7.5%) Occasional (29-5%) HP:0000682
19 cheilitis 56 32 hallmark (90%) Very frequent (99-80%) HP:0100825
20 papule 56 32 frequent (33%) Frequent (79-30%) HP:0200034
21 abnormality of the vagina 56 32 frequent (33%) Frequent (79-30%) HP:0000142
22 abnormality of the toenails 56 32 hallmark (90%) Very frequent (99-80%) HP:0008388
23 dyspareunia 56 32 frequent (33%) Frequent (79-30%) HP:0030016
24 broad nail 56 32 hallmark (90%) Very frequent (99-80%) HP:0001821
25 recurrent infections 56 Very frequent (99-80%)
26 abnormality of the eye 56 Occasional (29-5%)
27 abnormality of the nail 56 Very frequent (99-80%)
28 abnormality of the mouth 56 Very frequent (99-80%)
29 abnormality of the immune system 56 Very frequent (99-80%)
30 abnormality of the lip 56 Very frequent (99-80%)
31 abnormality of the skin 56 Very frequent (99-80%)

MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.45 CLEC7A IFNG IL10 IL17A IL17F IL17RB
2 immune system MP:0005387 10.45 IL4 IL6 STAT1 STAT3 TRAF3IP2 AIRE
3 hematopoietic system MP:0005397 10.44 AIRE CLEC7A IFNG IL10 IL17A IL17F
4 homeostasis/metabolism MP:0005376 10.4 IL18 IL23A IL23R IL2RA IL4 IL6
5 growth/size/body region MP:0005378 10.37 AIRE IFNG IL10 IL17A IL17F IL17RB
6 cellular MP:0005384 10.35 AIRE HSP90AA1 IFNG IL10 IL17RA IL17RB
7 endocrine/exocrine gland MP:0005379 10.31 IL2RA IL4 IL6 STAT1 STAT3 TRAF3IP2
8 mortality/aging MP:0010768 10.28 STAT3 TRAF3IP2 AIRE CLEC7A HSP90AA1 IFNG
9 integument MP:0010771 10.11 TRAF3IP2 IFNG IL10 IL17RA IL18 IL4
10 craniofacial MP:0005382 10.1 IFNG IL10 IL17A IL17F IL4 STAT3
11 neoplasm MP:0002006 10.02 AIRE IFNG IL10 IL17RA IL23A IL23R
12 liver/biliary system MP:0005370 9.98 AIRE IFNG IL10 IL4 IL6 STAT1
13 no phenotypic analysis MP:0003012 9.97 AIRE IFNG IL10 IL17A IL17RA IL23A
14 respiratory system MP:0005388 9.97 IL17A IL17F IL17RA IL17RB IL2RA IL4
15 normal MP:0002873 9.91 AIRE IFNG IL10 IL17F IL17RC IL23A
16 skeleton MP:0005390 9.61 IL10 IL17A IL17F IL17RB IL4 IL6
17 vision/eye MP:0005391 9.32 AIRE IFNG IL10 IL18 IL2RA IL4

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

Drugs for Chronic Mucocutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
2 Antifungal Agents Phase 3,Phase 2
3
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Antiparasitic Agents Phase 2
7 Antiprotozoal Agents Phase 2
8 Autoantibodies Phase 2,Phase 1
9 Liposomal amphotericin B Phase 2
10
rituximab Approved Phase 1 174722-31-7 10201696
11 Antibodies Phase 1
12 Antibodies, Monoclonal Phase 1
13 Antirheumatic Agents Phase 1
14 Immunoglobulins Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Open-Label Study to Evaluate Efficacy and Safety of SCY-078 in Patients With Refractory or Intolerant Fungal Diseases Recruiting NCT03059992 Phase 3 SCY-078
2 CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis Recruiting NCT02629419 Phase 2 Amphotericin B
3 Rituximab for Anti-cytokine Autoantibody-Associated Diseases Recruiting NCT01842386 Phase 1 Rituximab/Rituxan
4 Studies of Disorders With Increased Susceptibility to Fungal Infections Recruiting NCT01222741

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: candidiasis, chronic mucocutaneous

Genetic Tests for Chronic Mucocutaneous Candidiasis

Genetic tests related to Chronic Mucocutaneous Candidiasis:

id Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis 29

Anatomical Context for Chronic Mucocutaneous Candidiasis

MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

39
Skin, T Cells, Eye, Neutrophil, Lung, Monocytes, Bone Marrow

Publications for Chronic Mucocutaneous Candidiasis

Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50) (show all 262)
id Title Authors Year
1
A gain-of-function mutation of STAT1: A novel genetic factor contributing to chronic mucocutaneous candidiasis. ( 28597685 )
2017
2
Chronic Mucocutaneous Candidiasis. ( 28065688 )
2017
3
CMCD: Chronic Mucocutaneous Candidiasis Disease. ( 28603201 )
2017
4
A Novel Heterozygous Mutation in the STAT1 SH2 Domain Causes Chronic Mucocutaneous Candidiasis, Atypically Diverse Infections, Autoimmunity, and Impaired Cytokine Regulation. ( 28348565 )
2017
5
New and recurrent STAT1 mutations in seven Chinese patients with chronic mucocutaneous candidiasis. ( 27808400 )
2017
6
Chronic mucocutaneous candidiasis presenting as Candida endophthalmitis. ( 27085277 )
2016
7
Chronic mucocutaneous candidiasis: characterization of a family with STAT-1 gain-of-function and development of an ex-vivo assay for Th17 deficiency of diagnostic utility. ( 26621323 )
2016
8
Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. ( 26948078 )
2016
9
Ruxolitinib Induces Interleukin 17 and Ameliorates Chronic Mucocutaneous Candidiasis Caused by STAT1 Gain-of-Function Mutation. ( 26787170 )
2016
10
Treatment options for chronic mucocutaneous candidiasis. ( 27161991 )
2016
11
Th2 and Th9 responses in patients with chronic mucocutaneous candidiasis and hyper-IgE syndrome. ( 27474157 )
2016
12
The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1. ( 26604104 )
2016
13
Chronic mucocutaneous candidiasis disease associated with inborn errors of IL-17 immunity. ( 28090315 )
2016
14
Clinical heterogeneity of dominant chronic mucocutaneous candidiasis disease: presenting as treatment-resistant candidiasis and chronic lung disease. ( 26732859 )
2016
15
Clinical and immunological data of nine patients with chronic mucocutaneous candidiasis disease. ( 26981552 )
2016
16
Clonal Strain Persistence of Candida albicans Isolates from Chronic Mucocutaneous Candidiasis Patients. ( 26849050 )
2016
17
Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). ( 26255980 )
2015
18
Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. ( 25918342 )
2015
19
Recurrent inflammatory aortic aneurysms in chronic mucocutaneous candidiasis with a gain-of-function STAT1 mutation. ( 26080282 )
2015
20
Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation. ( 25662309 )
2015
21
A STAT1-gain-of-function mutation causing Th17 deficiency with chronic mucocutaneous candidiasis, psoriasiform hyperkeratosis and dermatophytosis. ( 26494717 )
2015
22
A novel gain-of-function STAT1 mutation resulting in basal phosphorylation of STAT1 and increased distal IFN-I^-mediated responses in chronic mucocutaneous candidiasis. ( 26514428 )
2015
23
Immunotherapy with G-CSF in patients with chronic mucocutaneous candidiasis. ( 25999307 )
2015
24
Two Novel Gain-of-Function Mutations of STAT1 Responsible for Chronic Mucocutaneous Candidiasis Disease: Impaired Production of IL-17A and IL-22, and the Presence of Anti-IL-17F Autoantibody. ( 25288569 )
2014
25
Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): Chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding. ( 25042743 )
2014
26
Altered immune responses in patients with chronic mucocutaneous candidiasis. ( 24582143 )
2014
27
Chronic mucocutaneous candidiasis: a case with exuberant cutaneous horns in nipples. ( 25054753 )
2014
28
Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis. ( 24343863 )
2013
29
New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe. ( 23709754 )
2013
30
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis. ( 24240291 )
2013
31
Autosomal dominant cases of chronic mucocutaneous candidiasis segregates with mutations of signal transducer and activator of transcription 1, but not of Toll-like receptor 3. ( 23541088 )
2013
32
Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion. ( 23791509 )
2013
33
IL-17 T Cells' Defective Differentiation In Vitro Despite Normal Range Ex Vivo in Chronic Mucocutaneous Candidiasis Due to STAT1 Mutation. ( 24335902 )
2013
34
Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1. ( 23122533 )
2013
35
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. ( 24120361 )
2013
36
Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism. ( 22847544 )
2012
37
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. ( 22730530 )
2012
38
Fungal granuloma of the brain in a case of chronic mucocutaneous candidiasis. ( 22724885 )
2012
39
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. ( 22403094 )
2012
40
Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. ( 23026768 )
2012
41
Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis? ( 21988702 )
2012
42
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. ( 21714643 )
2011
43
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. ( 21727188 )
2011
44
Defects in interleukin-17 immunity in the pathogenesis of chronic mucocutaneous candidiasis. ( 21766202 )
2011
45
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. ( 21350122 )
2011
46
Invariant natural killer T (iNKT) cell deficiency in chronic mucocutaneous candidiasis--a consequence or a cause? ( 20923687 )
2011
47
STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis. ( 22195034 )
2011
48
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. ( 21197459 )
2011
49
Chronic mucocutaneous candidiasis with endocrinopathy - case report. ( 22371787 )
2010
50
Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. ( 20123959 )
2010

Variations for Chronic Mucocutaneous Candidiasis

Expression for Chronic Mucocutaneous Candidiasis

Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for Chronic Mucocutaneous Candidiasis

Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 CLEC7A HSP90AA1 IFNG IL10 IL17A IL17F
2
Show member pathways
13.94 IL10 IL17A IL17RA IL17RC IL18 IL22
3
Show member pathways
13.73 HSP90AA1 IFNG IL10 IL17A IL17F IL17RA
4
Show member pathways
13.63 IFNG IL10 IL17A IL17RC IL18 IL22
5
Show member pathways
13.52 HSP90AA1 IL10 IL17A IL17RA IL17RC IL18
6
Show member pathways
13.44 HSP90AA1 IFNG IL10 IL17A IL17F IL17RA
7
Show member pathways
13.41 IL10 IL17A IL17RA IL17RC IL18 IL22
8
Show member pathways
12.98 HSP90AA1 IFNG IL10 IL17A IL22 IL2RA
9
Show member pathways
12.9 IFNG IL18 IL2RA IL4 IL6 STAT1
10
Show member pathways
12.85 IL22 IL2RA IL4 IL6 STAT1 STAT3
11
Show member pathways
12.75 HSP90AA1 IFNG IL10 IL17A IL17F IL18
12
Show member pathways
12.74 IFNG IL10 IL17A IL17F IL18 IL23A
13
Show member pathways
12.67 IFNG IL10 IL18 IL2RA IL4
14 12.67 IFNG IL10 IL17A IL2RA IL4 STAT1
15
Show member pathways
12.49 IFNG IL10 IL17A IL4 IL6
16
Show member pathways
12.41 HSP90AA1 IL4 STAT1 STAT3
17
Show member pathways
12.39 IFNG IL10 IL22 IL23A IL23R IL2RA
18
Show member pathways
12.39 HSP90AA1 IFNG IL17A IL17F IL17RA IL17RB
19 12.36 CLEC7A IFNG IL10 IL18 IL23A IL6
20
Show member pathways
12.34 IFNG IL6 STAT1 STAT3
21
Show member pathways
12.34 IFNG IL10 IL4 STAT1 STAT3
22
Show member pathways
12.3 IFNG IL10 IL17A IL18 IL4 IL6
23
Show member pathways
12.23 IFNG IL4 IL6 STAT1
24 12.22 IFNG IL6 STAT1 STAT3
25
Show member pathways
12.13 IFNG IL2RA STAT1 STAT3
26
Show member pathways
12.13 IFNG IL18 IL2RA IL4 STAT1 STAT3
27 12.12 IFNG IL10 IL2RA IL4 IL6
28
Show member pathways
12.12 IFNG IL10 IL17A IL18 IL23A IL23R
29
Show member pathways
12.08 HSP90AA1 IL2RA STAT1 STAT3
30 12.05 IFNG IL10 IL23R IL2RA IL6 STAT1
31 12.05 HSP90AA1 IL10 IL17A IL17F IL18 IL23A
32 11.99 IFNG IL17A IL18 IL23A IL6
33 11.94 HSP90AA1 IFNG IL4 IL6 STAT1
34 11.9 IFNG IL10 IL17RA IL23A IL6
35
Show member pathways
11.9 IFNG IL17A IL17F IL17RA IL22 IL23A
36
Show member pathways
11.89 IFNG STAT1 STAT3
37
Show member pathways
11.84 IL6 STAT1 STAT3
38 11.84 IFNG IL18 IL6
39 11.82 IL10 IL2RA IL4 IL6
40
Show member pathways
11.78 IFNG IL2RA IL4
41 11.78 IL10 IL23A IL6
42
Show member pathways
11.72 HSP90AA1 IL2RA IL4
43 11.7 IL10 IL18 IL4 IL6 STAT3
44
Show member pathways
11.66 IL6 STAT1 STAT3
45 11.66 IFNG IL10 IL17RB IL2RA IL4
46 11.65 IFNG STAT1 STAT3
47 11.65 IFNG IL10 IL18 IL6
48 11.63 IFNG IL23A IL6
49 11.59 HSP90AA1 IFNG IL6
50 11.56 IFNG IL10 IL17A IL17RB IL18 IL22

GO Terms for Chronic Mucocutaneous Candidiasis

Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 IFNG IL10 IL17A IL17F IL18 IL22
2 extracellular region GO:0005576 9.4 HSP90AA1 IFNG IL10 IL17A IL17F IL17RA
3 external side of plasma membrane GO:0009897 9.35 IFNG IL17A IL2RA IL4 IL6

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.99 IFNG IL23A IL6 STAT1
2 cytokine-mediated signaling pathway GO:0019221 9.97 IL17RA IL17RB IL17RC IL6 STAT3
3 defense response to Gram-negative bacterium GO:0050829 9.89 IL23A IL23R IL6
4 positive regulation of inflammatory response GO:0050729 9.89 IL17RA IL17RB IL18 IL23A
5 response to glucocorticoid GO:0051384 9.88 IL10 IL22 IL6
6 response to cytokine GO:0034097 9.88 IL4 IL6 STAT1 STAT3
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 IL18 IL6 STAT1
8 humoral immune response GO:0006959 9.86 AIRE IFNG IL6 TRAF3IP2
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 HSP90AA1 IFNG IL6
10 positive regulation of interferon-gamma production GO:0032729 9.84 IL18 IL23A IL23R
11 acute-phase response GO:0006953 9.81 IL22 IL6 STAT3
12 defense response to fungus GO:0050832 9.8 IL17A IL17RA IL17RC
13 cellular response to cytokine stimulus GO:0071345 9.79 IL17RA IL6 STAT3
14 positive regulation of interleukin-12 production GO:0032735 9.79 IFNG IL23A IL23R
15 positive regulation of interleukin-6 secretion GO:2000778 9.78 IL17A IL17F IL17RC
16 positive regulation of osteoclast differentiation GO:0045672 9.78 IFNG IL17A IL23A IL23R
17 positive regulation of activated T cell proliferation GO:0042104 9.77 IL18 IL23A IL23R IL2RA IL4
18 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.76 IL17A IL17F IL17RA IL17RC
19 positive regulation of interleukin-17 production GO:0032740 9.75 IL18 IL23A IL23R
20 positive regulation of T cell proliferation GO:0042102 9.73 IFNG IL23A IL23R IL2RA IL4 IL6
21 cellular response to hepatocyte growth factor stimulus GO:0035729 9.72 IL10 IL6
22 negative regulation of interleukin-10 production GO:0032693 9.72 IL23A IL23R
23 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.72 IFNG STAT1
24 positive regulation of T cell mediated cytotoxicity GO:0001916 9.72 IL23A IL23R
25 positive regulation of protein import into nucleus, translocation GO:0033160 9.72 IFNG IL6
26 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.72 IL18 IL23A IL23R
27 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 IFNG IL4
28 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IFNG IL4
29 interleukin-6-mediated signaling pathway GO:0070102 9.71 IL6 STAT3
30 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IFNG IL10 IL4
31 positive regulation of T-helper 1 type immune response GO:0002827 9.7 IL23A IL23R
32 positive regulation of T-helper 2 cell differentiation GO:0045630 9.7 IL18 IL6
33 positive regulation of T-helper 17 type immune response GO:2000318 9.7 IL23A IL23R
34 positive regulation of natural killer cell proliferation GO:0032819 9.7 IL18 IL23A IL23R
35 positive regulation of activation of Janus kinase activity GO:0010536 9.69 IL23A IL23R
36 regulation of tyrosine phosphorylation of STAT protein GO:0042509 9.69 IL23A IL23R
37 type 2 immune response GO:0042092 9.69 IL10 IL18 IL4
38 T-helper 17 cell lineage commitment GO:0072540 9.68 IL6 STAT3
39 positive regulation of interleukin-13 secretion GO:2000667 9.68 IL17RA IL17RB
40 positive regulation of tissue remodeling GO:0034105 9.68 IL18 IL23A
41 positive regulation of memory T cell differentiation GO:0043382 9.68 IL23A IL23R
42 granulocyte chemotaxis GO:0071621 9.67 IL17RA IL17RC
43 positive regulation of NK T cell activation GO:0051135 9.67 IL23A IL23R
44 positive regulation of interleukin-23 production GO:0032747 9.67 IFNG IL17A IL17RA
45 regulation of isotype switching GO:0045191 9.65 IL10 IL4
46 positive regulation of interleukin-5 secretion GO:2000664 9.65 IL17RA IL17RB
47 positive regulation of NK T cell proliferation GO:0051142 9.65 IL18 IL23A
48 positive regulation of T-helper 17 cell lineage commitment GO:2000330 9.64 IL23A IL23R
49 neutrophil apoptotic process GO:0001781 9.63 IFNG IL6
50 fibroblast activation GO:0072537 9.63 IL17A IL17RA

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 IFNG IL10 IL17A IL17F IL18 IL22
2 interleukin-17 receptor activity GO:0030368 9.13 IL17RA IL17RB IL17RC

Sources for Chronic Mucocutaneous Candidiasis

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