MCID: CHR063
MIFTS: 52

Chronic Mucocutaneous Candidiasis malady

Rare diseases, Infectious diseases, Skin diseases categories

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

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Aliases & Descriptions for Chronic Mucocutaneous Candidiasis:

Name: Chronic Mucocutaneous Candidiasis 10 45 12
Candidiasis, Chronic Mucocutaneous 65 36
 
Candidiasis Chronic Mucocutaneous 47 24
Mucocutaneous Candidiasis 10 65


Classifications:



External Ids:

Disease Ontology10 DOID:2058
MeSH36 D002178
SNOMED-CT59 234568006
NCIt42 C34444

Summaries for Chronic Mucocutaneous Candidiasis

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Disease Ontology:10 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to t-cell defects, has-agent candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

MalaCards based summary: Chronic Mucocutaneous Candidiasis, also known as candidiasis, chronic mucocutaneous, is related to hemolytic anemia and alopecia areata, and has symptoms including scaling of skin lesions, thickening of nails and swollen periungal tissue. An important gene associated with Chronic Mucocutaneous Candidiasis is AIRE (Autoimmune Regulator), and among its related pathways are African trypanosomiasis and OX40 Pathway. The drugs fluconazole and gentian violet have been mentioned in the context of this disorder. Affiliated tissues include skin, mucous membrane and nail due to t-cell defects, and related mouse phenotypes are skeleton and liver/biliary system.

Related Diseases for Chronic Mucocutaneous Candidiasis

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Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia30.8IFNG, IL10
2alopecia areata30.7IFNG, IL10, IL17A
3alopecia universalis30.5AIRE, IFNG
4skin tag30.5IL10, STAT1
5candidiasis11.4
6thymoma10.7
7dermatophytosis10.6
8aneurysm10.6
9systemic lupus erythematosus10.5
10immunodeficiency 31c, autosomal dominant10.5
11candidiasis, familial, 6, autosomal dominant10.5
12candidiasis, familial, 2, autosomal recessive10.5
13autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.5
14alopecia10.5
15esophagitis10.5
16histoplasmosis10.5
17hypothyroidism10.5
18lupus erythematosus10.5
19aplastic anemia10.4
20candidiasis, familial, 810.4
21keratitis10.4
22candidiasis, familial, 4, autosomal recessive10.4
23candidiasis, familial, 5, autosomal recessive10.4
24hepatitis10.4
25hypoparathyroidism10.4
26cerebritis10.4
27autoimmune hemolytic anemia10.4
28autoimmune polyendocrine syndrome10.4
29intracranial aneurysm10.4
30laryngitis10.4
31meningitis10.4
32vasculitis10.4
33bare lymphocyte syndrome, type ii, complementation group c10.3
34esophageal cancer10.3
35vici syndrome10.3
36acne10.3
37myasthenia gravis10.3
38nocardiosis10.3
39pemphigus10.3
40autoimmune polyendocrine syndrome type 110.3
41rosacea10.3
42aortic aneurysm10.3
43hypopituitarism10.3
44influenza10.3
45myositis10.3
46pneumonia10.3
47t cell deficiency10.3
48thyroiditis10.3
49aminoaciduria10.3
50haemophilus influenzae10.3

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to chronic mucocutaneous candidiasis

Symptoms for Chronic Mucocutaneous Candidiasis

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Symptoms:

 10
  • scaling of skin lesions
  • thickening of nails
  • swollen periungal tissue
  • scarring of the scalp

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

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Drugs for Chronic Mucocutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 11514174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab

Interventional clinical trials:

idNameStatusNCT IDPhase
1CAMB/MAT2203 in Patients With Mucocutaneous CandidiasisRecruitingNCT02629419Phase 2
2Rituximab for Anti-cytokine Autoantibody-Associated DiseasesRecruitingNCT01842386Phase 1
3Studies of Disorders With Increased Susceptibility to Fungal InfectionsRecruitingNCT01222741

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Candidiasis, Chronic Mucocutaneous

Genetic Tests for Chronic Mucocutaneous Candidiasis

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Genetic tests related to Chronic Mucocutaneous Candidiasis:

id Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis24

Anatomical Context for Chronic Mucocutaneous Candidiasis

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MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

33
T cells, Skin, Bone, Neutrophil, Thymus, Monocytes, Bone marrow

FMA organs/tissues related to Chronic Mucocutaneous Candidiasis:

16
Skin, Mucous membrane, Nail due to t-cell defects

Animal Models for Chronic Mucocutaneous Candidiasis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7IFNG, IL10, IL17A, IL17F, STAT1
2MP:00053708.6AIRE, IFNG, IL10, IL22, STAT1
3MP:00107718.2IFNG, IL10, IL17RA, IL22, STAT1
4MP:00028738.0AIRE, IFNG, IL10, IL17F, IL17RC, STAT1
5MP:00020067.8AIRE, IFNG, IL10, IL17RA, IL22, STAT1
6MP:00053817.7AIRE, IFNG, IL10, IL17A, IL17F, IL22
7MP:00030127.7AIRE, IFNG, IL10, IL17A, IL17RA, IL22
8MP:00107687.6AIRE, IFNG, IL10, IL17A, IL17F, IL22
9MP:00053887.4AIRE, IFNG, IL10, IL17A, IL17F, IL17RA
10MP:00053976.9AIRE, IFNG, IL10, IL17A, IL17F, IL17RA
11MP:00053766.4AIRE, IFNG, IL10, IL17A, IL17RA, IL17RC
12MP:00053875.8AIRE, IFNG, IL10, IL17A, IL17F, IL17RA

Publications for Chronic Mucocutaneous Candidiasis

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Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50)    (show all 243)
idTitleAuthorsYear
1
Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. (25918342)
2015
2
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. (22730530)
2012
3
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. (22403094)
2012
4
Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism. (22847544)
2012
5
Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis? (21988702)
2012
6
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. (21197459)
2011
7
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. (20123958)
2010
8
Autosomal dominant chronic mucocutaneous candidiasis and primary hypothyroidism complicated by oesophageal carcinoma. (19778308)
2009
9
Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED. (19037923)
2008
10
Altered, but not diminished specific T cell response in chronic mucocutaneous candidiasis patients. (17960405)
2007
11
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
12
Chronic mucocutaneous candidiasis in a child. (16394492)
2005
13
Disseminated Candida tropicalis in a patient with chronic mucocutaneous candidiasis. (15352680)
2004
14
Polyglandular autoimmune syndrome type 1 without chronic mucocutaneous candidiasis in a 16 year-old male. (12585347)
2003
15
The syndrome of chronic mucocutaneous candidiasis with selective antibody deficiency. (12602677)
2003
16
Histopathologic and scanning electron microscope examination of the nail and hair in chronic mucocutaneous candidiasis. (12894108)
2003
17
Antigliadin antibodies associated with chronic mucocutaneous candidiasis. (12383098)
2002
18
Haemophilus influenzae type D infection and IgG2 deficiency in a patient with chronic mucocutaneous candidiasis. (8203272)
1994
19
Chronic mucocutaneous candidiasis. (8077500)
1994
20
Fatal pulmonary nocardiosis in a patient with chronic mucocutaneous candidiasis. (8064079)
1994
21
Vascular nodules and plaques resembling chronic mucocutaneous candidiasis in a patient with a low interleukin 2 level. (8349866)
1993
22
Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis. (1986107)
1991
23
KID syndrome (keratitis, ichthyosis, and deafness) and chronic mucocutaneous candidiasis: case report and review of the literature. (6390393)
1984
24
Immunological observations before and after successful treatment of chronic mucocutaneous candidiasis with ketoconazole and transfer factor. (6096150)
1984
25
Chronic mucocutaneous candidiasis. (6317830)
1983
26
Chronic mucocutaneous candidiasis and keratitis associated with malignant thymoma. (6838096)
1983
27
Impaired generation of helper T cells in a patient with chronic mucocutaneous candidiasis and malignant thymoma. (6221110)
1983
28
Treatment of chronic mucocutaneous candidiasis with 5-fluorocytosine. (6756218)
1982
29
Severe hepatitis associated with ketoconazole therapy for chronic mucocutaneous candidiasis. (6284445)
1982
30
Chronic mucocutaneous Candidiasis-endocrinopathies. (7318499)
1981
31
Chronic mucocutaneous candidiasis with candida granuloma treated with 5-fluorocytosine. (7227606)
1981
32
A serum-dependent defect of neutrophil function in chronic mucocutaneous candidiasis. (6995490)
1980
33
Chronic mucocutaneous candidiasis and disseminated histoplasmosis. (7358883)
1980
34
Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. (316285)
1979
35
Immunological investigation of patients with chronic mucocutaneous candidiasis. (399626)
1979
36
Symposium: Chronic mucocutaneous candidiasis. (552463)
1979
37
Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole. (434848)
1979
38
Plasma thymic hormone activity in patients with chronic mucocutaneous candidiasis. (743805)
1978
39
Clotrimazole: intermittent therapy in chronic mucocutaneous candidiasis. (842517)
1977
40
Chronic mucocutaneous candidiasis. Immunologic evaluation and therapy. (844330)
1977
41
Chronic mucocutaneous candidiasis, dermatophytosis and defective cellular immunity in monozygotic twins. (4134659)
1974
42
Chronic mucocutaneous candidiasis. (4470726)
1974
43
Selective hypopituitarism. Impaired cell-mediated immunity and chronic mucocutaneous candidiasis. (4740720)
1973
44
Chronic mucocutaneous candidiasis: iron deficiency and the effects of iron therapy. (4733977)
1973
45
Transfer factor in the treatment of a case of chronic mucocutaneous candidiasis. (4554089)
1972
46
Chronic mucocutaneous candidiasis, myositis, and thymoma. A new triad. (4564702)
1972
47
Treatment of chronic mucocutaneous candidiasis with leucocytes from HL-A compatible sibling. (4109818)
1972
48
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4192497)
1970
49
Transfer of cellular hypersensitivity in chronic mucocutaneous candidiasis monitored in vivo and in vitro. (5523582)
1970
50
Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities. Report of a syndrome of superficial candidiasis, absence of delayed hypersensitivity and aminoaciduria. (5822974)
1969

Variations for Chronic Mucocutaneous Candidiasis

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Expression for genes affiliated with Chronic Mucocutaneous Candidiasis

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Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for genes affiliated with Chronic Mucocutaneous Candidiasis

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Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IFNG, IL10
29.6IFNG, IL10
39.6IFNG, IL10
4
Show member pathways
9.6IFNG, IL10
59.6IFNG, STAT1
69.2IFNG, IL10, STAT1
7
Show member pathways
9.2IFNG, IL10, STAT1
8
Show member pathways
8.8IFNG, IL10, IL17A, STAT1
9
Show member pathways
8.8IFNG, IL10, IL17A, STAT1
10
Show member pathways
8.6IFNG, IL10, IL22, STAT1
11
Show member pathways
8.4IFNG, IL10, IL17A, IL17F, STAT1
12
Show member pathways
8.3IL17A, IL17F, IL17RA, IL17RC
13
Show member pathways
8.3IL17A, IL17F, IL17RA, IL17RC
148.3IFNG, IL10, IL17A, IL17RA, STAT1
15
Show member pathways
7.7IFNG, IL10, IL17A, IL17F, IL22, STAT1
16
Show member pathways
7.7IL10, IL17A, IL17RA, IL17RC, IL22
17
Show member pathways
7.6IFNG, IL17A, IL17F, IL17RA, IL22, STAT1
18
Show member pathways
7.3IL10, IL17A, IL17RA, IL17RC, IL22, STAT1
19
Show member pathways
7.3IFNG, IL10, IL17A, IL17RC, IL22, STAT1
20
Show member pathways
7.2IFNG, IL10, IL17A, IL17RA, IL17RC, IL22

GO Terms for genes affiliated with Chronic Mucocutaneous Candidiasis

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Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1IFNG, IL10, IL17A, IL17F, IL22
2extracellular regionGO:00055767.6IFNG, IL17A, IL17F, IL17RA, IL22

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:004534810.2IFNG, IL10
2regulation of interferon-gamma-mediated signaling pathwayGO:006033410.2IFNG, STAT1
3fibroblast activationGO:007253710.2IL17A, IL17RA
4defense response to protozoanGO:004283210.1IFNG, IL10
5negative regulation of growth of symbiont in hostGO:004413010.1IFNG, IL10
6positive regulation of osteoclast differentiationGO:00456729.9IFNG, IL17A
7positive regulation of interleukin-23 productionGO:00327479.7IFNG, IL17A, IL17RA
8cellular response to lipopolysaccharideGO:00712229.5IFNG, IL10, STAT1
9cell-cell signalingGO:00072679.4IL10, IL17A, IL22
10positive regulation of transcription, DNA-templatedGO:00458939.0AIRE, IFNG, IL10, STAT1
11immune responseGO:00069559.0AIRE, IFNG, IL10, IL17A
12positive regulation of cytokine production involved in inflammatory responseGO:19000178.9IL17A, IL17F, IL17RA, IL17RC
13inflammatory responseGO:00069548.9IL10, IL17A, IL17F, IL22
14positive regulation of transcription from RNA polymerase II promoterGO:00459448.0AIRE, IFNG, IL10, IL17A, IL17F, STAT1
15cytokine-mediated signaling pathwayGO:00192217.9IFNG, IL17RA, IL17RC, STAT1

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor bindingGO:000512610.0IL17A, IL17F
2interleukin-17 receptor activityGO:00303689.6IL17RA, IL17RC
3cytokine activityGO:00051258.1IFNG, IL10, IL17A, IL17F, IL22

Sources for Chronic Mucocutaneous Candidiasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet