MCID: CHR063
MIFTS: 63

Chronic Mucocutaneous Candidiasis malady

Summaries for Chronic Mucocutaneous Candidiasis

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to t-cell defects, has-agent candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

MalaCards: Chronic Mucocutaneous Candidiasis, also known as mucocutaneous candidiasis, is related to candidiasis and thymoma, and has symptoms including scarring of the scalp, swollen periungal tissue and thickening of nails. An important gene associated with Chronic Mucocutaneous Candidiasis is AIRE (autoimmune regulator), and among its related pathways are Rheumatoid arthritis and IL-22 Pathway. The drugs ketoconazole and itraconazole and the compounds indomethacin and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include nail due to t-cell defects, mucous membrane and skin, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Wikipedia:63 Chronic mucocutaneous candidiasis is an immune disorder of T cells. It is characterized by chronic... more...

Description from OMIM:46 613108,212050

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

chronic mucocutaneous candidiasis 8 22 10
mucocutaneous candidiasis 8 60
candidiasis, chronic mucocutaneous 60
candidiasis chronic mucocutaneous 44


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Disease Ontology8 DOID:2058
SNOMED-CT56 234568006
NCIt39 C34444
MeSH34 D002178

Related Diseases for Chronic Mucocutaneous Candidiasis

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17GeneCards, 18GeneDecks
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Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis32.0AIRE, CARD9
2thymoma30.9AIRE
3alopecia areata30.6AIRE
4hypothyroidism30.6AIRE
5systemic lupus erythematosus30.6IFNB1, STAT1, MPO, CD86, IL2RA, IL23A
6autoimmune polyendocrine syndrome30.5CARD9
7hypoparathyroidism30.5AIRE
8keratitis30.5IL17A
9vasculitis30.5IL17A, MPO
10hepatitis30.5IL22, AIRE, STAT1, IFNB1
11pneumonia30.5MPO, IL17F, IL17A, IL22
12thyroiditis30.3PTPN22
13autoimmune polyendocrine syndrome type 130.3PFKL
14myasthenia gravis30.3CD86, AIRE
15vitiligo30.3PTPN22, AIRE
16oral candidiasis10.6
17candidiasis, familial, 2, autosomal recessive10.5
18esophageal candidiasis10.4
19alopecia10.4
20dermatophytosis10.4
21esophagitis10.4
22histoplasmosis10.4
23lupus erythematosus10.4
24t cell deficiency10.4
25cerebritis10.3
26intracranial aneurysm10.3
27chronic laryngitis10.3
28autoimmune hemolytic anemia10.3
29aplastic anemia10.3
30chronic meningitis10.3
31hemolytic anemia10.3
32laryngitis10.3
33meningitis10.3
34rosacea10.2
35nocardiosis10.2
36pemphigus10.2
37t lymphocyte deficiency10.2
38acne10.2
39b cell deficiency10.2
40chromosomal disease10.2
41esophageal cancer10.2
42fungal meningitis10.2
43hypopituitarism10.2
44influenza10.2
45myositis10.2
46candidiasis familial chronic mucocutaneous, autosomal recessive10.2
47candidiasis, familial, 810.2
48autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.2
49alopecia universalis10.1
50good syndrome10.1

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to chronic mucocutaneous candidiasis

Clinical Features for Chronic Mucocutaneous Candidiasis

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Sources:
46OMIM, 8Disease Ontology
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Clinical features from OMIM:

613108,212050

Symptoms:

8
  • scarring of the scalp
  • swollen periungal tissue
  • thickening of nails
  • scaling of skin lesions

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Mucocutaneous Candidiasis

Drug clinical trials:

Search ClinicalTrials for Chronic Mucocutaneous Candidiasis

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Search CenterWatch for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Chronic Mucocutaneous Candidiasis

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22GTR
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Genetic tests related to Chronic Mucocutaneous Candidiasis:

id Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis22

Anatomical Context for Chronic Mucocutaneous Candidiasis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

32
T cells, Skin, Thymus, Monocytes, Bone, Bone marrow, Liver, Lung, Thyroid, Brain, B cells

FMA organs/tissues related to Chronic Mucocutaneous Candidiasis:

14
Nail due to t-cell defects, Mucous membrane, Skin

Animal Models for Chronic Mucocutaneous Candidiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.1IL22, AIRE
2MP:00030129.5IFNB1, STAT1, AIRE, IL17RA
3MP:00020069.2IFNB1, STAT1, AIRE, IL23A, IL17RA, IL22
4MP:00053818.7STAT1, AIRE, IL2RA, IL17F, IL23A, IL17A
5MP:00107687.7PVRL1, STAT1, MPO, AIRE, PFKL, CLEC6A
6MP:00053847.7IFNB1, STAT1, AIRE, CD86, CD83, CLEC6A
7MP:00053767.5AIRE, MPO, STAT1, IFNB1, CARD9, PVRL1
8MP:00053977.3CD83, CD86, AIRE, MPO, STAT1, IFNB1
9MP:00053877.1PTPN22, CARD9, IFNB1, STAT1, MPO, AIRE

Publications for Chronic Mucocutaneous Candidiasis

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Sources:
50PubMed
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Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. (22403094)
2012
2
Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism. (22847544)
2012
3
Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis? (21988702)
2012
4
Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. (23026768)
2012
5
Chronic mucocutaneous candidiasis with endocrinopathy - case report. (22371787)
2010
6
Esophageal cancer associated with chronic mucocutaneous candidiasis. Could chronic candidiasis lead to esophageal cancer? (18798115)
2009
7
Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. (19196253)
2009
8
Altered, but not diminished specific T cell response in chronic mucocutaneous candidiasis patients. (17960405)
2007
9
Chronic mucocutaneous candidiasis - an immunological mystery. (18250935)
2007
10
Chronic mucocutaneous candidiasis in a 6-year-old boy. (15221041)
2004
11
Histopathologic and scanning electron microscope examination of the nail and hair in chronic mucocutaneous candidiasis. (12894108)
2003
12
Immunology of chronic mucocutaneous candidiasis. (11215289)
2001
13
Cerebral vasculitis in chronic mucocutaneous candidiasis: autopsy case report. (11211056)
2000
14
Cerebral vasculitis associated with chronic mucocutaneous candidiasis. (9787702)
1998
15
Intestinal protothecosis in a patient with chronic mucocutaneous candidiasis. (9709896)
1998
16
Chronic mucocutaneous candidiasis. I. Altered antigen-stimulated IL-2, IL-4, IL-6 and interferon-gamma (IFN-gamma) production. (8706323)
1996
17
Chronic mucocutaneous candidiasis. II. Class and subclass of specific antibody responses in vivo and in vitro. (8706324)
1996
18
Disseminated histoplasmosis in chronic mucocutaneous candidiasis. (8516028)
1993
19
Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis. (1986107)
1991
20
Chronic mucocutaneous candidiasis in childhood and complications of non-Candida infection: a report of the Pediatric Immunodeficiency Collaborative Study Group. (2308026)
1990
21
The "yeast connection" meets chronic mucocutaneous candidiasis. (3951526)
1986
22
KID syndrome (keratitis, ichthyosis, and deafness) and chronic mucocutaneous candidiasis: case report and review of the literature. (6390393)
1984
23
Therapy of chronic mucocutaneous candidiasis. (6295148)
1983
24
Chronic mucocutaneous candidiasis with IgA deficiency in a two-year-old African girl who responded well to ketoconazole. (6197018)
1983
25
Severe chronic mucocutaneous candidiasis. Favourable response to oral therapy with ketoconazole. (6298584)
1983
26
Long-term therapy of chronic mucocutaneous candidiasis with ketoconazole: experience with twenty-one patients. (6295149)
1983
27
Treatment of chronic mucocutaneous candidiasis with 5-fluorocytosine. (6756218)
1982
28
Chronic mucocutaneous candidiasis treated with ketoconazole. (6291894)
1982
29
Ketoconazole in the treatment of chronic mucocutaneous candidiasis secondary to autoimmune polyendocrinopathy-candidiasis syndrome. (6288325)
1982
30
Chronic mucocutaneous Candidiasis-endocrinopathies. (7318499)
1981
31
Chronic mucocutaneous candidiasis with hypoparathyroidism. (7287153)
1981
32
Candida laryngitis in chronic mucocutaneous candidiasis. Its association with Candida esophagitis. (7458151)
1980
33
Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. (316285)
1979
34
Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole. (434848)
1979
35
Cimetidine in chronic mucocutaneous candidiasis. (507856)
1979
36
Chronic mucocutaneous candidiasis clinically exacerbated by type I hypersensitivity. (314371)
1979
37
Chronic mucocutaneous candidiasis, pernicious anaemia and IgA deficiency. (313806)
1979
38
Non-candidal infections in children with chronic mucocutaneous candidiasis. (459201)
1979
39
Subpopulations of human T lymphocytes. XI. T cells with receptors for IgM or IgG and locomotion of T and non-T cells in peripheral blood from patients with chronic mucocutaneous candidiasis. (314372)
1979
40
Treatment of chronic mucocutaneous candidiasis. (842993)
1977
41
Chronic mucocutaneous candidiasis with macrophage dysfunction, a plasma inhibitor, and co-existent aplastic anemia. (124324)
1975
42
Chronic mucocutaneous candidiasis, dermatophytosis and defective cellular immunity in monozygotic twins. (4134659)
1974
43
Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man. (4549559)
1974
44
Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. (4571566)
1973
45
Chronic mucocutaneous candidiasis with abnormal function of serum complement. (4741333)
1973
46
Treatment of chronic mucocutaneous candidiasis of children (Candida Granuloma) with Clotrimazole. (4337938)
1972
47
Studies on lymphocyte and monocyte function in chronic mucocutaneous candidiasis. (5099755)
1971
48
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4193722)
1970
49
Lymphocyte abnormality in chronic mucocutaneous candidiasis. (4193340)
1970
50
The cellular immune defect in chronic mucocutaneous candidiasis. (4182179)
1969

Genetic Variations for Chronic Mucocutaneous Candidiasis

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Expression for genes affiliated with Chronic Mucocutaneous Candidiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Mucocutaneous Candidiasis

Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for genes affiliated with Chronic Mucocutaneous Candidiasis

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore
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Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD86
210.0IL22, STAT1
3
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9.9IL17A, CD86, STAT1
4
Mucin expression in CF via IL-6, IL-17 signaling pathways
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9.7IL17D, IL17F, IL17RA, IL17A
59.6STAT1, CD86, IL2RA, IL22
6
Hide members
9.5IL2RA, STAT1, IFNB1, PVRL1
79.5CARD9, IFNB1, STAT1, IL23A
8
Cytokine production by Th17 cells in CF (Mouse model)
9.5IL17F, IL23A, IL17RA, IL17A, IL23R
9
Development PDGF signaling via STATs and NF-kB
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9.2STAT1, MPO, IL17F, IL23A, IL17A, IL23R
10
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9.2IFNB1, STAT1, IL2RA, IL23A, IL22
11
Hide members
9.2STAT1, IL17F, IL23A, IL17A, IL22, IL23R
12
Hide members
9.1PVRL1, IL2RA, IL23A, IL22, IL23R, PTPN22
139.0IFNB1, STAT1, IL2RA, IL23A, IL22, IL23R
14
Hide members
9.0STAT1, PFKL, IL2RA, IL23A, IL22, IL23R
15
Hide members
8.9IL23R, STAT1, CD86, IL17F, IL23A, IL17RA
16
Hide members
8.8IFNB1, IL2RA, IL23A, IL17RA, IL17A, IL22

Compounds for genes affiliated with Chronic Mucocutaneous Candidiasis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.4IFNB1
2endotoxin4410.3STAT1, CD86
3flagellin44 2811.0CD86, STAT1, IFNB1
4trinitrobenzenesulfonic acid449.9IL17A, MPO
5natalizumab44 1110.9IL2RA, IFNB1
62,5-oligoadenylate449.9IFNB1, STAT1, IL2RA
7polyinosinic-polycytidylic acid449.9IFNB1, STAT1, CD83
8ifn-alpha449.8IL17A, IL2RA, STAT1, IFNB1
9rantes449.6IFNB1, STAT1, IL2RA, IL17RA, IL17A
10cyclosporin a44 28 5911.5STAT1, CD86, CD83, IL2RA, IL17A
11sb 20358044 5910.3IFNB1, STAT1, AIRE, IL17A
12dexamethasone44 49 28 1112.2IL17A, IL2RA, CD83, CD86, STAT1, IFNB1
13tyrosine448.8PVRL1, IFNB1, STAT1, AIRE, CD86, IL2RA
14pge2448.8IL17A, IFNB1, STAT1, MPO, CD86, CD83

GO Terms for genes affiliated with Chronic Mucocutaneous Candidiasis

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16Gene Ontology
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Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL17A, IL2RA, CD83, CD86
2extracellular spaceGO:0056159.0MPO, IL17D, IL17F, IL17A, IL22, IFNB1

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-2 biosynthetic processGO:04507610.5CARD9, IL17F
2regulation of interleukin-6 biosynthetic processGO:04540810.5IL17F, CARD9
3fibroblast activationGO:07253710.5IL17A, IL17RA
4positive regulation of interleukin-23 productionGO:03274710.4IL17RA, IL17A
5positive regulation of cytokine production involved in inflammatory responseGO:190001710.3IL17A, IL17RA, IL17F
6regulation of tyrosine phosphorylation of Stat1 proteinGO:04251010.3IL23R, IL23A
7positive regulation of T-helper 17 cell lineage commitmentGO:200033010.3IL23A, IL23R
8positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.3IL23A, IL23R
9positive regulation of NK T cell activationGO:05113510.3IL23A, IL23R
10positive regulation of memory T cell differentiationGO:04338210.3IL23A, IL23R
11positive regulation of T-helper 17 type immune responseGO:200031810.3IL23A, IL23R
12positive regulation of natural killer cell proliferationGO:03281910.2IL23A, IL23R
13positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.2IL23A, IL23R
14positive regulation of activation of JAK2 kinase activityGO:01053510.2IL23A, IL23R
15response to exogenous dsRNAGO:04333010.2CARD9, STAT1
16negative regulation of interleukin-10 productionGO:03269310.2IL23R, IL23A
17positive regulation of T-helper 1 type immune responseGO:00282710.2IL23A, IL23R
18positive regulation of osteoclast differentiationGO:04567210.2IL23R, IL17A, IL23A
19positive regulation of activated T cell proliferationGO:04210410.1IL23R, IL23A, IL2RA
20positive regulation of interleukin-17 productionGO:03274010.1IL23R, IL23A
21humoral immune responseGO:00695910.0CD83, AIRE, IFNB1
22positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0IL23A, IL23R
23defense response to fungusGO:0508329.9CLEC6A, MPO
24immune responseGO:0069559.9PVRL1, AIRE, CD86, IL2RA, IL17A
25positive regulation of interleukin-10 productionGO:0327339.8CD83, IL23A
26defense response to virusGO:0516079.7CARD9, IFNB1, STAT1, CD86, IL23A
27positive regulation of defense response to virus by hostGO:0022309.7IL23A, IL23R
28inflammatory responseGO:0069549.5IL17D, IL17F, IL23A, IL17A, IL22, IL23R
29positive regulation of transcription from RNA polymerase II promoterGO:0459449.5IFNB1, STAT1, AIRE, IL17F, IL23A, IL17A
30innate immune responseGO:0450879.3CARD9, IFNB1, CD86, CLEC6A, IL23A

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IL22, IL17A, IL23A, IL17F, IL17D, IFNB1

Products for genes affiliated with Chronic Mucocutaneous Candidiasis

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Sources for Chronic Mucocutaneous Candidiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet