CML
MCID: CHR065
MIFTS: 74

Chronic Myeloid Leukemia (CML) malady

Blood diseases, Cancer diseases categories

Summaries for Chronic Myeloid Leukemia

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic myeloid leukemia (cml), there are too many granulocytes, a type of white blood cell. most people with cml have a gene mutation (change) called the philadelphia chromosome. sometimes cml does not cause any symptoms. if you have symptoms, they may include: fatigue weight loss night sweats fever pain or a feeling of fullness below the ribs on the left side tests that examine the blood and bone marrow diagnose cml. treatments include chemotherapy, stem cell transplants, infusion of donated white blood cells following stem cell transplants, surgery to remove the spleen, and biologic and targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Chronic Myeloid Leukemia, also known as leukemia, chronic myeloid, is related to leukemia and myeloid leukemia. An important gene associated with Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are MicroRNAs in cancer and Pathways in cancer. The drugs busulfan and cyclophosphamide and the compounds tyrosine and imatinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow.

Wikipedia:63 Chronic myelogenous (or myeloid) leukemia (CML), also known as chronic granulocytic leukemia (CGL), is a... more...

Description from OMIM:46 608232

Aliases & Classifications for Chronic Myeloid Leukemia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 9diseasecard, 22GTR, 46OMIM, 44Novoseek, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
chronic myeloid leukemia:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

chronic myeloid leukemia 8 42 10 48 33 30
leukemia, chronic myeloid 9 42 22 46
chronic myelogenous leukemia 8 42 48
chronic granulocytic leukemia 42 48
myeloid leukemia, chronic 8 60
cml 8 42
chronic myeloid leukemia without mention of remission 8
chronic myelogenous leukemia, no icd-o subtype 8
chronic myeloid leukemia in remission 8
cml - chronic myelogenous leukemia 8
myeloid leukemia chronic 44
cml in remission 8


External Ids:

Disease Ontology8 DOID:8552
ICD9CM27 205.1
MeSH34 D015464
OMIM46 608232
NCIt39 C3174
ICD10 via Orphanet26 C92.1
SNOMED-CT via Orphanet57 63364005, 92818009
UMLS via Orphanet61 C0023473

Related Diseases for Chronic Myeloid Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia chronic myeloid leukemia
Myeloid Leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia

Diseases related to Chronic Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5CRKL, PRAME, HOXA@, HOXA9, ABL1, BMI1
2myeloid leukemia32.5ABL1, HOXA9, BMI1, RUNX1, BCR
3acute leukemia31.3ABL1, BMI1, BCR, RUNX1, HOXA9, PRAME
4polycythemia vera30.6IFNA1
5acute lymphocytic leukemia30.5RUNX1, BCR, HOXA9, PRAME, ABL1, CRKL
6sarcoma30.5RUNX1
7monocytic leukemia30.3RUNX1
8retinoblastoma30.2BMI1, RUNX1, BCR, ABL1
9myelofibrosis29.8BCR, IFNA1
10acute myeloid leukemia10.9
11t-cell leukemia10.7
12chronic lymphocytic leukemia10.7
13lymphoid leukemia10.6
14lymphoblastic leukemia10.6
15thrombocytosis10.5
16polycythemia10.4
17subacute myeloid leukemia10.4
18natural killer cell leukemia10.4
19priapism10.4
20graft versus host disease10.3
21central nervous system leukemia10.3
22myeloid sarcoma10.3
23chromosomal disease10.3
24chronic polyneuropathy10.3
25glomerulonephritis10.3
26hepatitis10.3
27polyneuropathy10.3
28philadelphia-negative chronic myeloid leukemia10.3
29bronchiolitis obliterans organizing pneumonia10.3
30bronchiolitis obliterans10.3
31bronchiolitis10.3
32hodgkin's lymphoma10.3
33obesity10.3
34membranoproliferative glomerulonephritis10.2
35juvenile myelomonocytic leukemia10.2
36acute t cell leukemia10.2
37hepatitis b10.2
38chronic monocytic leukemia10.2
39gynecomastia10.2
40hypercalcemia10.2
41anaplastic large cell lymphoma10.2
42hepatitis a10.2
43adenocarcinoma10.2
44childhood leukemia10.2
45chronic myeloproliferative disease10.2
46colon adenocarcinoma10.2
47hairy cell leukemia10.2
48hypertension10.2
49hypopyon10.2
50plasmacytoma10.2

Graphical network of the top 20 diseases related to Chronic Myeloid Leukemia:



Diseases related to chronic myeloid leukemia

Clinical Features for Chronic Myeloid Leukemia

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46OMIM
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Clinical features from OMIM:

608232

Clinical synopsis from OMIM:

608232

Drugs & Therapeutics for Chronic Myeloid Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Chronic Myeloid Leukemia

Search NIH Clinical Center for Chronic Myeloid Leukemia

Search CenterWatch for Chronic Myeloid Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Myeloid Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Myeloid Leukemia

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Sources:
22GTR
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Genetic tests related to Chronic Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Chronic Myeloid Leukemia22

Anatomical Context for Chronic Myeloid Leukemia

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32MalaCards
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MalaCards organs/tissues related to Chronic Myeloid Leukemia:

32
Myeloid, Bone, Bone marrow, Testes, Spleen, T cells, B cells, Endothelial, Testis, Lymph node, Colon, Monocytes, Heart, Lung, Kidney, Skin, B lymphoblasts

Animal Models for Chronic Myeloid Leukemia or affiliated genes

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Publications for Chronic Myeloid Leukemia

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50PubMed
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Articles related to Chronic Myeloid Leukemia:

(show top 50)    (show all 1319)
idTitleAuthorsYear
1
U.s. Food and drug administration approval summary: omacetaxine mepesuccinate as treatment for chronic myeloid leukemia. (24309980)
2014
2
Activin A induction of erythroid differentiation sensitizes K562 chronic myeloid leukemia cells to a subtoxic concentration of imatinib. (24088895)
2014
3
HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia. (24151050)
2013
4
Omacetaxine mepesuccinate (synribo) - newly launched in chronic myeloid leukemia. (23875628)
2013
5
Imatinib and chronic myeloid leukemia: close to the bone. (23383598)
2013
6
Assay of OAZ1 mRNA Levels in Chronic Myeloid Leukemia Combined with Application of Leukemia PCR Array Identified Relevant Gene Changes Affected by Antizyme. (24192781)
2013
7
Overcoming chronic myeloid leukemia stem cell resistance to imatinib by also targeting JAK2. (23446756)
2013
8
Gene expression profiling of chronic myeloid leukemia with variant t(9;22) reveals a different signature from cases with classic translocation. (23642027)
2013
9
Phase 2 study of subcutaneous omacetaxine mepesuccinate for chronic-phase chronic myeloid leukemia patients resistant to or intolerant of tyrosine kinase inhibitors. (23468307)
2013
10
Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: when is this a safe option to consider? (24319180)
2013
11
Phosphorylated Crkl reduction levels are associated with the lowest P-glycoprotein activity levels in cells from chronic myeloid leukemia patients. (24210993)
2013
12
More about imatinib and nilotinib combination therapy in chronic myeloid leukemia. (22986736)
2013
13
Changes in molecular biology of chronic myeloid leukemia in tyrosine kinase inhibitor era. (23997982)
2013
14
Morphologic Changes in the Bone Marrow in Patients of Chronic Myeloid Leukemia (CML) Treated with ImatinibMesylate. (23997453)
2012
15
Ponatinib for chronic myeloid leukemia. (23190226)
2012
16
Optimizing second-line therapy for chronic myeloid leukemia. (22842168)
2012
17
Absence of DNMT3A gene mutation in chronic myeloid leukemia patients in blast crisis. (22251315)
2012
18
Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells. (21890458)
2011
19
ABL domain kinase point mutations as a cause of resistance to therapy of patients with chronic myeloid leukemia with tyrosine kinase inhibitors. Single center experience]. (21961412)
2011
20
Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily. (20934998)
2011
21
RAD 001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia. (20014066)
2010
22
A unique BCR-ABL1 transcript with the insertion of intronic sequence from BCR and ABL1 genes in a patient with Philadelphia-positive chronic myeloid leukemia: a case study. (20633771)
2010
23
Glutathione S-transferase M1 and T1 genes and susceptibility to chronic myeloid leukemia: a meta-analysis. (19860557)
2009
24
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells. (19039322)
2009
25
RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation. (19282830)
2009
26
Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications. (18559609)
2008
27
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks. (18524993)
2008
28
Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. (17568400)
2008
29
Imatinib mesylate therapy in chronic myeloid leukemia patients in stable complete cytogenic response after interferon-alpha results in a very high complete molecular response rate. (17692911)
2008
30
High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects. (17412886)
2007
31
In vitro cytokines-induced differentiation in mononuclear cell derived dendritic cells from chronic myeloid leukemia]. (16584610)
2006
32
WT1 overexpression: a clinically useful marker in acute and chronic myeloid leukemias. (16188642)
2005
33
Correlation of major cytogenetic response with a pharmacogenetic marker in chronic myeloid leukemia patients treated with imatinib (STI571). (15073101)
2004
34
Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. (12393722)
2003
35
Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia. (12800198)
2003
36
Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. (14562121)
2003
37
Imatinib mesylate (Gleevec, Glivec): a new therapy for chronic myeloid leukemia and other malignancies. (12582448)
2002
38
Treatment of residual disease in chronic myeloid leukemia with STI-571 (Glivec)]. (12506764)
2002
39
Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia. (10463572)
1999
40
Studies of some mechanisms of drug resistance in chronic myeloid leukemia (CML). (10500825)
1999
41
Development of acute promyelocytic leukemia with isochromosome 17q after BCR/ABL positive chronic myeloid leukemia. (10087949)
1999
42
Fluorescence in situ hybridization (FISH) on peripheral blood smears for monitoring Philadelphia chromosome-positive chronic myeloid leukemia (CML) during interferon treatment: a new strategy for remission assessment. (9491319)
1998
43
Naturally processed tissue- and differentiation stage-specific autologous peptides bound by HLA class I and II molecules of chronic myeloid leukemia blasts. (9389712)
1997
44
Synergistic effects of interleukin-11 with other growth factors on the expansion of hematopoietic progenitors from normal individuals and chronic myeloid leukemia patients resistant to treatment with cytosine arabinoside or eilatin. (8947585)
1996
45
Southern technique and cytogenetics are complementary and must be used together in the evaluation of Ph1, M-BCR positive chronic myeloid leukemia (CML) patients treated with alpha interferon (IFN-alpha). (8895687)
1996
46
Treatment of chronic myeloid leukemia in children and adolescents--concept of the multicenter pilot study CML-ped]. (8926690)
1996
47
The detection of Philadelphia chromosome negative metaphases in long-term bone marrow cultures of the peripheral blood from patients with chronic myeloid leukemia predicts response to interferon-alpha 2a. (1453769)
1992
48
Molecular biology of chronic myeloid leukemia]. (1488867)
1992
49
Alpha-2b-interferon as single therapy for patients with chronic myeloid leukemia relapsing after T-cell depleted allogeneic bone marrow transplantation. (2279545)
1990
50
Chronic myeloid leukemia with hemarthrosis. A case report. (5231484)
1967

Genetic Variations for Chronic Myeloid Leukemia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Chronic Myeloid Leukemia:

62
id Symbol AA change Variation ID SNP ID
1SETBP1p.Asp868AsnVAR_063807
2SETBP1p.Gly870SerVAR_063809
3SETBP1p.Ile871ThrVAR_063810
4SETBP1p.Glu858LysVAR_069849

Expression for genes affiliated with Chronic Myeloid Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Chronic Myeloid Leukemia.

Pathways for genes affiliated with Chronic Myeloid Leukemia

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29KEGG, 4Cell Signaling Technology
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Pathways related to Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3ABL1, MIR17, MIR451A, MIR150, MIR199B, CRKL
211.0BCR, ABL1, CRKL, RUNX1
311.0RUNX1, CRKL, ABL1, BCR
410.9BCR, ABL1, CRKL

Compounds for genes affiliated with Chronic Myeloid Leukemia

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4411.5RUNX1, IFNA1, CRKL, PCM1, HOXA9, ABL1
2imatinib44 49 1113.4BCR, SLC22A1, ABL1, CRKL, IFNA1, RUNX1
3cytarabine44 49 1113.1IFNA1, ABL1, SLC22A1, BCR
4nucleoside4410.8IFNA1, ABL1, SLC22A1
5amantadine44 1111.7SLC22A1, IFNA1
6acyclovir44 1111.7SLC22A1, IFNA1
7busulfan44 1111.4BCR, IFNA1

GO Terms for genes affiliated with Chronic Myeloid Leukemia

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16Gene Ontology
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Biological processes related to Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:04800810.7BCR, ABL1
2definitive hemopoiesisGO:06021610.4HOXA9, RUNX1

Products for genes affiliated with Chronic Myeloid Leukemia

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Sources for Chronic Myeloid Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet