CML
MCID: CHR065
MIFTS: 71

Chronic Myeloid Leukemia (CML) malady

Genetic diseases, Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Chronic Myeloid Leukemia

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34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in chronic myeloid leukemia (cml), there are too many granulocytes, a type of white blood cell. most people with cml have a gene mutation (change) called the philadelphia chromosome. sometimes cml does not cause any symptoms. if you have symptoms, they may include: fatigue weight loss night sweats fever pain or a feeling of fullness below the ribs on the left side tests that examine the blood and bone marrow diagnose cml. treatments include chemotherapy, stem cell transplants, infusion of donated white blood cells following stem cell transplants, surgery to remove the spleen, and biologic and targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Chronic Myeloid Leukemia, also known as leukemia, chronic myeloid, is related to myeloid leukemia and leukemia. An important gene associated with Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Chronic myeloid leukemia. The drugs busulfan and cyclophosphamide and the compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow.

Wikipedia:65 Chronic myelogenous (or myeloid or myelocytic) leukemia (CML), also known as chronic granulocytic... more...

Description from OMIM:47 608232

Aliases & Classifications for Chronic Myeloid Leukemia

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 34MedlinePlus, 31LifeMap Discoveryâ„¢, 62UMLS, 9diseasecard, 22GTR, 47OMIM, 45Novoseek, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
chronic myeloid leukemia:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

chronic myeloid leukemia 8 43 10 49 34 31
leukemia, chronic myeloid 9 43 22 47
chronic myelogenous leukemia 8 43 49
chronic granulocytic leukemia 43 49
myeloid leukemia, chronic 8 62
cml 8 43
chronic myeloid leukemia without mention of remission 8
chronic myelogenous leukemia, no icd-o subtype 8
chronic myeloid leukemia in remission 8
cml - chronic myelogenous leukemia 8
myeloid leukemia chronic 45
cml in remission 8


External Ids:

Disease Ontology8 DOID:8552
ICD9CM27 205.1
NCIt40 C3174
MeSH35 D015464
OMIM47 608232
ICD10 via Orphanet26 C92.1
SNOMED-CT via Orphanet59 63364005, 92818009
UMLS via Orphanet63 C0023473

Related Diseases for Chronic Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia chronic myeloid leukemia
Myeloid Leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia Inherited Acute Myeloid Leukemia
Acute Myeloid Leukemia with T(9;11)(p22;q23) Acute Myeloid Leukemia with T(8;16)(p11;p13)
Acute Myeloid Leukemia with T(6;9)(p23;q34)

Diseases related to Chronic Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1myeloid leukemia32.6RUNX1, ABL1, ETV6, BCR
2leukemia32.5RUNX1, HOXA@, ABL1, PRAME, ETV6, IFNA1
3myelofibrosis30.9BCR, IFNA1
4myelodysplastic syndromes30.8RUNX1, ABL1, ETV6
5acute leukemia30.7RUNX1, ABL1, PRAME, ETV6, BCR
6chronic myelomonocytic leukemia30.7BCR, ETV6, RUNX1
7acute lymphocytic leukemia30.6BCR, ETV6, PRAME, ABL1, RUNX1
8juvenile myelomonocytic leukemia30.5RUNX1
9myeloproliferative disorder30.4RUNX1, ABL1, ETV6, IFNA1, BCR
10gastrointestinal stromal tumor30.3BCR, ABL1
11acute myelomonocytic leukemia30.2ETV6, RUNX1
12philadelphia-negative chronic myeloid leukemia10.6
13hematopoietic stem cell transplantation10.6
14lymphoblastic leukemia10.6
15thrombocytosis10.5
16polycythemia10.5
17endotheliitis10.5
18subacute myeloid leukemia10.4
19polycythemia vera10.4
20priapism10.4
21leukemoid reaction10.4
22graft versus host disease10.4
23acute myeloid leukemia10.4
24chronic lymphocytic leukemia10.4
25glomerulonephritis10.4
26hepatitis10.4
27polyneuropathy10.4
28sarcoma10.4
29essential thrombocythemia10.4
30bronchiolitis10.3
31bronchiolitis obliterans10.3
32bronchiolitis obliterans organizing pneumonia10.3
33hodgkin's lymphoma10.3
34obesity10.3
35acute basophilic leukemia10.3
36membranoproliferative glomerulonephritis10.3
37hepatitis b10.3
38gynecomastia10.3
39hypercalcemia10.3
40anaplastic large cell lymphoma10.3
41adenocarcinoma10.3
42colon adenocarcinoma10.3
43colorectal cancer10.3
44hairy cell leukemia10.3
45hypertension10.3
46hypopyon10.3
47plasmacytoma10.3
48thrombocytopenia10.3
49wilms tumor10.3
50acute promyelocytic leukemia10.3

Graphical network of the top 20 diseases related to Chronic Myeloid Leukemia:



Diseases related to chronic myeloid leukemia

Symptoms for Chronic Myeloid Leukemia

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47OMIM
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Symptoms by clinical synopsis from OMIM:

608232

Clinical features from OMIM:

608232

Drugs & Therapeutics for Chronic Myeloid Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discoveryâ„¢, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Chronic Myeloid Leukemia

Search NIH Clinical Center for Chronic Myeloid Leukemia

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Myeloid Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Myeloid Leukemia

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22GTR
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Genetic tests related to Chronic Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Chronic Myeloid Leukemia22

Anatomical Context for Chronic Myeloid Leukemia

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33MalaCards
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MalaCards organs/tissues related to Chronic Myeloid Leukemia:

33
Myeloid, Bone, Bone marrow, Testes, Spleen, T cells, B cells, Endothelial, Testis, Colon, Lymph node, Monocytes, Skin, Heart, Lung, Kidney, B lymphoblasts

Animal Models for Chronic Myeloid Leukemia or affiliated genes

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Publications for Chronic Myeloid Leukemia

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52PubMed
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Articles related to Chronic Myeloid Leukemia:

(show top 50)    (show all 1241)
idTitleAuthorsYear
1
Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation. (24334603)
2014
2
Intraventricular hemorrhage in a patient with chronic myeloid leukemia and anterior communicating artery aneurysm. (23860156)
2013
3
Treatment-, patient-, and disease-related factors and the emergence of adverse events with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia. (23553655)
2013
4
Sudden extramedullary blast crisis of chronic myeloid leukemia manifesting as T-cell lymphoblastic lymphoma. (23486000)
2013
5
Dasatinib: a guide to its use in chronic myeloid leukemia in the EU. (23549840)
2013
6
Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells. (23878608)
2013
7
p-Stat3 and bcr/abl gene expression in chronic myeloid leukemia and their relation to imatinib therapy. (24374144)
2013
8
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. (23275297)
2013
9
Bone metabolism, growth rate and pubertal development in children with chronic myeloid leukemia treated with imatinib during puberty. (22983586)
2013
10
Successful rechallenge with imatinib in a patient with chronic myeloid leukemia who previously experienced imatinib mesylate induced pneumonitis. (24416057)
2013
11
Chronic phase chronic myeloid leukemia patients with low OCT-1 activity randomized to high-dose imatinib achieve better responses and have lower failure rates than those randomized to standard-dose imatinib. (22207690)
2012
12
Targeting of GSK3I^ promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. (22262776)
2012
13
Chronic myeloid leukemia with extreme thrombocytosis. (22479272)
2012
14
Primary cutaneous anaplastic large-cell lymphoma occurring in a case of chronic myeloid leukemia in remission. (22775801)
2012
15
Low-level Bcr-Abl mutations are very rare in chronic myeloid leukemia patients who are in major molecular response on first-line nilotinib. (21762985)
2011
16
Summary of 615 patients of chronic myeloid leukemia in Shanghai from 2001 to 2006. (20199658)
2010
17
RAD 001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia. (20014066)
2010
18
Analysis of CYP3A5*3 and CYP3A5*6 gene polymorphisms in Indian chronic myeloid leukemia patients. (21039054)
2010
19
Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells. (21203397)
2010
20
Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression. (19420358)
2009
21
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. (18401414)
2008
22
Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib. (17688946)
2008
23
Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. (19061839)
2008
24
Philadelphia chromosome-positive chronic myeloid leukemia with p190(BCR-ABL) rearrangement, overexpression of the EVI1 gene, and extreme thrombocytosis: a case report. (18262061)
2008
25
Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. (17064874)
2007
26
Efficacy and safety of imatinib in patients with chronic myeloid leukemia and complete or near-complete cytogenetic response to interferon-alpha. (17607681)
2007
27
Immunotherapeutic strategies in chronic myeloid leukemia. (20425356)
2007
28
Recovery of polyclonial hemopoiesis in females with chronic myeloid leukemia with a complete cytogenetic response]. (17926464)
2007
29
Adenomatoid tumor of the testis in a patient on imatinib therapy for chronic myeloid leukemia. (16923575)
2006
30
Chronic myeloid leukemia: current application of cytogenetics and molecular testing for diagnosis and treatment. (15757021)
2005
31
Factors predicting molecular and cytogenetic response in chronic myeloid leukemia patients treated with imatinib. (15642682)
2005
32
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides. (15626746)
2005
33
Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. (15034867)
2004
34
Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib. (15512807)
2004
35
Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. (12393722)
2003
36
Granulocyte colony-stimulating factor reverses cytopenia and may permit cytogenetic responses in patients with chronic myeloid leukemia treated with imatinib mesylate. (12604417)
2003
37
Analysis of cytogenetic response in Ph+ chronic myeloid leukemia patients treated with interferon alpha]. (12844411)
2003
38
Usefulness of quantitative assessment of Wilms tumor suppressor gene expression in chronic myeloid leukemia patients undergoing imatinib therapy. (12783374)
2003
39
Treatment of chronic myeloid leukemia with autologous transplantation using peripheral blood stem cells or bone marrow cultured in IL-2 followed by IL-2, GM-CSF, and IFN-alpha administration. (12665687)
2003
40
Drug therapy of chronic myeloid leukemia]. (11831070)
2002
41
Cytokine expression of T cells in chronic myeloid leukemia. (11775253)
2000
42
Quantitative evaluation of BCR-ABL amount of transcript post mobilization with G-CSF of peripheral blood stem cells from chronic myeloid leukemia patients in cytogenetic response. (10975389)
2000
43
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. (10534772)
1999
44
Absence of influence of prior treatment with interferon on the outcome of allogeneic bone marrow transplantation for chronic myeloid leukemia. (9678795)
1998
45
Lineage involvement of stem cells bearing the philadelphia chromosome in chronic myeloid leukemia in the chronic phase as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization. (9845542)
1998
46
Fluorescence in situ hybridization (FISH) on peripheral blood smears for monitoring Philadelphia chromosome-positive chronic myeloid leukemia (CML) during interferon treatment: a new strategy for remission assessment. (9491319)
1998
47
P53, p15INK4B, p16INK4A and p57KIP2 mutations during the progression of chronic myeloid leukemia. (10069444)
1998
48
The role of DNA damage in the resistance of human chronic myeloid leukemia cells to cyclophosphamide analogues. (7923171)
1994
49
Management of chronic myeloid leukemia in chronic phase with autologous stem cell transplantation and alpha-2 interferon: cytogenetic and clinical results. (7902746)
1993
50
"Coexistent chronic myeloid leukemia and lymphosarcoma in the maxilla: report of a case". (6594459)
1984

Variations for Chronic Myeloid Leukemia

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64UniProtKB/Swiss-Prot
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UniProtKB/Swiss-Prot genetic disease variations for Chronic Myeloid Leukemia:

64
id Symbol AA change Variation ID SNP ID
1SETBP1p.Asp868AsnVAR_063807
2SETBP1p.Gly870SerVAR_063809
3SETBP1p.Ile871ThrVAR_063810
4SETBP1p.Glu858LysVAR_069849

Expression for genes affiliated with Chronic Myeloid Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Chronic Myeloid Leukemia.

Pathways for genes affiliated with Chronic Myeloid Leukemia

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50PathCards, 51PharmGKB, 30KEGG
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Compounds for genes affiliated with Chronic Myeloid Leukemia

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51PharmGKB, 11DrugBank, 45Novoseek, 29IUPHAR
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Compounds related to Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate5110.5ABL1, BCR
2nilotinib51 1111.5BCR, ABL1
3homoharringtonine45 51 1112.4BCR, IFNA1, ABL1
4busulfan45 51 1112.4ABL1, IFNA1, BCR
5amantadine45 1111.3IFNA1, SLC22A1
6nucleoside4510.3ABL1, IFNA1, SLC22A1
7cytarabine45 51 1112.3SLC22A1, BCR, IFNA1, ABL1
8ponatinib51 1111.3BCR, ABL1
9acyclovir45 1111.3SLC22A1, IFNA1
10prednisolone45 29 1112.3IFNA1, ETV6, RUNX1
11lamivudine45 51 1112.2SLC22A1, IFNA1
12imatinib45 51 1112.2SLC22A1, RUNX1, ABL1, ETV6, IFNA1, BCR
13dmso4510.1RUNX1, ABL1, BCR
14dasatinib45 51 1112.0BCR, ABL1
15tyrosine4510.0RUNX1, ABL1, ETV6, IFNA1, PCM1, BCR

GO Terms for genes affiliated with Chronic Myeloid Leukemia

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16Gene Ontology
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Biological processes related to Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:04800810.3BCR, ABL1

Products for genes affiliated with Chronic Myeloid Leukemia

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Sources for Chronic Myeloid Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet