MCID: CHR285
MIFTS: 53

Chronic Myelomonocytic Leukemia malady

Cancer, Blood categories

Summaries for Chronic Myelomonocytic Leukemia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming... more...

MalaCards: Chronic Myelomonocytic Leukemia, also known as leukemia, myelomonocytic, chronic, is related to acute myelomonocytic leukemia and acute leukemia. An important gene associated with Chronic Myelomonocytic Leukemia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are LDL Oxidation in Atherogenesis and Alpha-defensins. The compounds pixy321 and molgramostim have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and brain, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Chronic Myelomonocytic Leukemia

Sources:
43NIH Rare Diseases, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 45Novoseek, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
chronic myelomonocytic leukemia:
Age of onset: Adulthood


Aliases & Descriptions:

chronic myelomonocytic leukemia 43 49 31
leukemia, myelomonocytic, chronic 43 61
leukemia myelomonocytic chronic 45


External Ids:

ICD10 via Orphanet26 C93.1
SNOMED-CT via Orphanet58 127225006, 128831004
UMLS via Orphanet62 C0023480
MESH via Orphanet36 D015477
ICD1025 C93.1

Related Diseases for Chronic Myelomonocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chronic Myelomonocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1acute myelomonocytic leukemia31.3CSF1, MPO, ETV6
2acute leukemia31.3CSF2, CSF1, GATA2, FLT3, TOP1, MPO
3chronic myeloid leukemia31.2PDGFRB, CSF2, GATA2, FLT3, MPO, NRAS
4myelodysplastic syndromes31.1GATA2, FLT3, TOP1, MPO, NRAS, ETV6
5juvenile myelomonocytic leukemia31.0CSF2, FLT3, NRAS
6refractory anemia30.8CSF2, CSF1, FLT3
7mastocytosis30.7PDGFRB
8systemic mastocytosis30.7PDGFRB, TET2
9myeloproliferative disorder30.6ETV6, MPO, FLT3, CSF2, PDGFRB
10acute monocytic leukemia30.4MPO, CSF1
11acute lymphocytic leukemia30.4CSF2, GATA2, FLT3, TOP1, MPO, ETV6
12polycythemia vera30.2PDGFRB, FLT3, TET2, ASXL1
13adenocarcinoma30.2TOP1, PDGFRB
14myeloid sarcoma30.2MPO
15aplastic anemia30.2CSF2, CSF1, GATA2, FLT3
16acute promyelocytic leukemia30.2CSF1, GATA2, FLT3, MPO, NRAS
17t-cell leukemia10.7
18leukemia, t-cell, chronic10.7
19acute myeloid leukemia10.7
20chronic monocytic leukemia10.5
21leukemia, b-cell, chronic10.5
22testicular leukemia10.4
23n syndrome10.4
24vasculitis10.4
25antiphospholipid syndrome10.3
26mast-cell leukemia10.3
27pyoderma gangrenosum10.3
28adult syndrome10.3
29plasma cell leukemia10.3
30generalized eruptive histiocytosis10.3
31lymphoid leukemia10.2
32cardiac tamponade10.2
33relapsing polychondritis10.2
34porphyria cutanea tarda10.2
35diphtheria10.2
36subacute leukemia10.2
37folliculitis10.2
38noonan syndrome10.2
39severe congenital neutropenia10.2
40calciphylaxis10.2
41factor xi deficiency10.2
42factor x deficiency10.2
43factor xii deficiency10.2
44factor xiii deficiency10.2
45aortitis10.2
46natural killer cell leukemia10.2
47thrombotic thrombocytopenic purpura10.2
48leukostasis10.2
49follicular mucinosis10.2
50malignant histiocytosis10.2

Graphical network of the top 20 diseases related to Chronic Myelomonocytic Leukemia:



Diseases related to chronic myelomonocytic leukemia

Clinical Features for Chronic Myelomonocytic Leukemia

Drugs & Therapeutics for Chronic Myelomonocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Myelomonocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Chronic Myelomonocytic Leukemia

Search NIH Clinical Center for Chronic Myelomonocytic Leukemia

Search CenterWatch for Chronic Myelomonocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Myelomonocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myelomonocytic Leukemia:
Hemacord
Embryonic/Adult Cultured Cells Related to Chronic Myelomonocytic Leukemia:
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244

Genetic Tests for Chronic Myelomonocytic Leukemia

Anatomical Context for Chronic Myelomonocytic Leukemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Chronic Myelomonocytic Leukemia:

33
Bone marrow, Spleen, Brain, Colon, Kidney, Liver, Adrenal gland, Breast, Skin, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Fetal brain, Fetal liver

Animal Models for Chronic Myelomonocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Chronic Myelomonocytic Leukemia

Sources:
51PubMed
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Articles related to Chronic Myelomonocytic Leukemia:

(show top 50)    (show all 409)
idTitleAuthorsYear
1
Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia. (23307061)
2013
2
Chronic myelomonocytic leukemia diagnosed by means of mutational analysis in a patient with persistent monocytosis and tuberculosis. (23327289)
2013
3
Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance. (23335386)
2013
4
SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias. (23443343)
2013
5
Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia. (22773603)
2013
6
Reciprocal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemias: review of 5,654 patients with an evaluable karyotype. (23686965)
2013
7
CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia (FPD/AML). (22138511)
2012
8
Laboratory diagnosis of chronic myelomonocytic leukemia and progression to acute leukemia in association with chronic lymphocytic leukemia: morphological features and immunophenotypic profile. (23049428)
2012
9
Transcription intermediary factor 1I^ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia. (21537084)
2011
10
Allogeneic hematopoietic cell transplantation for chronic myelomonocytic leukemia: relapse-free survival is determined by karyotype and comorbidities. (20932924)
2011
11
Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting. (19718057)
2010
12
Outcome of allo-SCT for chronic myelomonocytic leukemia. (18997830)
2009
13
A forgotten cause of kidney injury in chronic myelomonocytic leukemia. (19185401)
2009
14
The detection of CD14 and CD16 in paraffin-embedded bone marrow biopsies is useful for the diagnosis of chronic myelomonocytic leukemia. (19242719)
2009
15
Abolishment of pleural effusion as the initial manifestation of chronic myelomonocytic leukemia without chemotherapy. (19039201)
2008
16
Sustained response to low-dose imatinib mesylate in a patient with chronic myelomonocytic leukemia with t(5;12)(q33;p13). (18268406)
2008
17
Therapy-related chronic myelomonocytic leukemia with unique chromosomal abnormalities: monosomy 7 and t(12;17)(p13;q11.2). (16924641)
2007
18
Molecular cytogenetic findings in a four-way t(1;12;5;12)(p36;p13;q33;q24) underlying the ETV6-PDGFRB fusion gene in chronic myelomonocytic leukemia. (17574967)
2007
19
Trisomy 19 as the sole chromosomal abnormality in proliferative chronic myelomonocytic leukemia. (16464494)
2006
20
Flow cytometric analysis of monocytes as a tool for distinguishing chronic myelomonocytic leukemia from reactive monocytosis. (16203279)
2005
21
A case of calciphylaxis and chronic myelomonocytic leukemia. (16047870)
2005
22
Differentiating juvenile myelomonocytic leukemia from chronic myeloid leukemia in childhood. (15087951)
2004
23
AML1/RUNX1 fusion gene and t(5;21)(q13;q22) in a case of chronic myelomonocytic leukemia with progressive thrombocytopenia and monocytosis. (15262442)
2004
24
Chronic myelomonocytic leukemia with abnormal bone marrow eosinophils. (12946218)
2003
25
Detection of c-kit point mutation Asp-816 --> Val in microdissected pooled single mast cells and leukemic cells in a patient with systemic mastocytosis and concomitant chronic myelomonocytic leukemia. (12363464)
2002
26
Chronic myelomonocytic leukemia revealed by uncontrollable hematuria. (11300938)
2001
27
Chronic urticaria associated with chronic myelomonocytic leukemia. (11206941)
2000
28
Generation of dendritic cells from human chronic myelomonocytic leukemia cells in fetal calf serum-free medium. (10953979)
2000
29
Pericardial effusion in chronic myelomonocytic leukemia (CMML): a case report and review of the literature. (11077120)
2000
30
Chronic myelomonocytic leukemia derived from a possible common progenitor of monocytes and natural killer cells. (11042523)
2000
31
Localized pulmonary infiltration in chronic myelomonocytic leukemia]. (9577644)
1998
32
A case of chronic myelomonocytic leukemia with isochromosome 14q. (9494615)
1998
33
Results of intensive chemotherapy in children with juvenile chronic myelomonocytic leukemia: a pilot study. (9835905)
1998
34
Extramedullary myeloid cell tumors arising in the setting of chronic myelomonocytic leukemia. A report of two cases. (8554447)
1996
35
Systemic mastocytosis associated with chronic myelomonocytic leukemia: clinical features and response to interferon alfa therapy. (7722042)
1995
36
Myelomonocytic antigens in B-cell chronic lymphocytic leukemia. (8551801)
1995
37
Long-term response to interferon-alpha in a patient with systemic mastocytosis and chronic myelomonocytic leukemia. (8042625)
1994
38
Chronic myelomonocytic leukemia: Tel-a-kinase what Ets all about. (8168126)
1994
39
Cutaneous involvement in chronic myelomonocytic leukemia. (8002157)
1994
40
Five monoclonal proteins in a patient with chronic myelomonocytic leukemia. (1609787)
1992
41
Philadelphia-negative (Ph-) chronic myeloid leukemia (CML): comparison with Ph+ CML and chronic myelomonocytic leukemia. The Groupe FranAsais de CytogAcnActique HAcmatologique. (2070054)
1991
42
Chronic myelomonocytic leukemia: clinical data, morphological features, and outcome in 56 patients. (2323647)
1990
43
Trisomy 11 in chronic myelomonocytic leukemia: report of two cases and review of the literature. (3275488)
1988
44
Translocation (1;7) in a case of secondary chronic myelomonocytic leukemia. (3466683)
1987
45
Chronic myelomonocytic leukemia following refractory anemia with sideroblasts: report of two cases. (3474153)
1987
46
Chronic myelomonocytic leukemia presenting as a keratouveitis. (3459388)
1986
47
Chronic myelomonocytic leukemia according to FAB classification: analysis of 35 cases. (6582939)
1984
48
Defective terminal maturation along monocyte-macrophage lineage in chronic myelomonocytic leukemia. (6438980)
1984
49
Characteristics of granulocyte-macrophage colony formation in patients with chronic myelomonocytic leukemia. (6183760)
1982
50
Chronic myelomonocytic leukemia in adults. (4136589)
1974

Genetic Variations for Chronic Myelomonocytic Leukemia

Expression for genes affiliated with Chronic Myelomonocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Myelomonocytic Leukemia

Search GEO for disease gene expression data for Chronic Myelomonocytic Leukemia.

Pathways for genes affiliated with Chronic Myelomonocytic Leukemia

Sources:
52QIAGEN, 54Reactome, 50PharmGKB, 60Tocris Bioscience, 30KEGG, 38NCBI BioSystems Database
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Compounds for genes affiliated with Chronic Myelomonocytic Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR
See all sources

Compounds related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1pixy3214510.6FLT3, CSF1, CSF2
2molgramostim4510.6CSF1, CSF2
3idarubicin45 50 1112.6TOP1, FLT3, CSF2
4aclarubicin4510.6TOP1, CSF1
5bcnu4510.6TOP1, CSF1, CSF2
6budesonide45 50 1112.5CSF2, CSF1, MPO
7fluticasone propionate45 50 60 1113.5MPO, CSF1, CSF2
8pkc 4124510.5FLT3, PDGFRB
9ifosfamide45 1111.5CSF2, CSF1, TOP1
10methylcellulose4510.5CSF2, CSF1, GATA2, FLT3
11gp 1304510.5PDGFRB, CSF2, CSF1, FLT3
12n-formylmethionyl-leucylphenylalanine4510.5CSF2, CSF1, MPO
13carboplatin45 50 1112.5MPO, TOP1, CSF1, CSF2
14imatinib45 50 1112.5ETV6, FLT3, CSF1, PDGFRB
15anti-fungal4510.5CSF2, CSF1, DEFA3, DEFA1
16hydroxyurea45 50 1112.5CSF2, CSF1, GATA2, TOP1
17mitoxantrone45 50 1112.4MPO, TOP1, FLT3, CSF1, CSF2
18daunorubicin45 50 1112.4CSF2, CSF1, FLT3, TOP1, MPO
19cyclophosphamide45 50 1112.4MPO, TOP1, CSF1, CSF2
20ag-12964510.4PDGFRB, FLT3
21cytarabine45 50 1112.4CSF2, CSF1, FLT3, TOP1, MPO
22butyrate4510.4GATA2, CSF1, CSF2
235fluorouracil4510.4PDGFRB, CSF2, CSF1, TOP1, MPO
24hbd24510.4DEFA3, DEFA1
25agar4510.4PDGFRB, CSF2, CSF1, TOP1, NRAS, ETV6
26su54164510.4FLT3, PDGFRB
27etoposide45 50 60 1113.4CSF2, CSF1, FLT3, TOP1
28leukotriene b445 60 2412.4MPO, CSF1, CSF2
29cisplatin45 50 60 1113.3MPO, TOP1, CSF1, CSF2, PDGFRB
30h2o24510.3PDGFRB, CSF2, CSF1, TOP1, MPO
31prednisolone45 29 1112.2ETV6, MPO, CSF1
32vegf4510.2PDGFRB, CSF2, CSF1, FLT3, MPO, ETV6
33retinoic acid45 2411.2PDGFRB, CSF2, CSF1, GATA2, FLT3, MPO
34doxorubicin45 50 1112.1CSF2, CSF1, FLT3, TOP1
35tyrosine4510.0PDGFRB, CSF2, CSF1, FLT3, NRAS, HIP1
36capecitabine45 50 1112.0TOP1, PDGFRB
37oligonucleotide4510.0PDGFRB, GATA2, FLT3, NRAS, DNMT3A

GO Terms for genes affiliated with Chronic Myelomonocytic Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAP kinase activityGO:04340610.3EZH2, FLT3, PDGFRB
2definitive hemopoiesisGO:06021610.3HOXA9, GATA2
3dendritic cell differentiationGO:09702810.2FLT3, CSF2
4positive regulation of cell proliferationGO:00828410.1PDGFRB, CSF2, CSF1, FLT3, NRAS
5positive regulation of macrophage derived foam cell differentiationGO:01074410.0CSF1, CSF2

Molecular functions related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036829.7EZH2, DNMT3A, MPO, TOP1, GATA2
2protein bindingGO:0055159.3HIP1, TOP1, FLT3, GATA2, CSF2, DNMT3A

Products for genes affiliated with Chronic Myelomonocytic Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Myelomonocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet