MCID: CHR285
MIFTS: 48

Chronic Myelomonocytic Leukemia malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases categories

Aliases & Classifications for Chronic Myelomonocytic Leukemia

About this section
Sources:
30LifeMap Discovery®, 42NIH Rare Diseases, 48Orphanet, 61UMLS, 44Novoseek, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Chronic Myelomonocytic Leukemia:

Name: Chronic Myelomonocytic Leukemia 30 42 48
Leukemia, Myelomonocytic, Chronic 42 61
 
Leukemia Myelomonocytic Chronic 44


Classifications:



Characteristics (Orphanet epidemiological data):

48
chronic myelomonocytic leukemia:
Age of onset: Adult


External Ids:

Orphanet48 98823
MESH via Orphanet34 D015477
ICD10 via Orphanet26 C93.1
UMLS via Orphanet62 C0023480
ICD1025 C93.1

Summaries for Chronic Myelomonocytic Leukemia

About this section
Wikipedia:64 Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming... more...

MalaCards based summary: Chronic Myelomonocytic Leukemia, also known as leukemia, myelomonocytic, chronic, is related to myelodysplastic syndrome and systemic mastocytosis. An important gene associated with Chronic Myelomonocytic Leukemia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Validated targets of C-MYC transcriptional repression and Signaling events mediated by TCPTP. The compounds topotecan and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related mouse phenotypes are integument and embryogenesis.

Related Diseases for Chronic Myelomonocytic Leukemia

About this section

Diseases in the Acute Myelomonocytic Leukemia family:

Leukemia, Juvenile Myelomonocytic chronic myelomonocytic leukemia

Diseases related to Chronic Myelomonocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1myelodysplastic syndrome31.9CSF1, NRAS
2systemic mastocytosis31.3TET2, PDGFRB
3myelofibrosis31.1PDGFRB, TET2, ASXL1
4leukemia, juvenile myelomonocytic31.1NRAS, FLT3
5myeloid leukemia31.0ETV6, FLT3, CSF1
6refractory anemia31.0CSF1, FLT3
7eosinophilia30.8PDGFRB, CSF1, ETV6
8acute myelomonocytic leukemia30.7ETV6, CSF1
9sarcoma30.5PDGFRB, CSF1, ETV6, NRAS
10acute leukemia30.5CSF1, ETV6, FLT3
11aplastic anemia30.3FLT3, CSF1
12polycythemia vera30.2TET2, FLT3, PDGFRB, ASXL1
13leukemia30.2PDGFRB, TET2, FLT3, RAN, EZH2, ASXL1
14breast cancer28.6EZH2, FLT3, ETV6, DNMT3A, CSF1, NRAS
15mastocytosis10.6
16chronic lymphocytic leukemia10.5
17thrombocytopenia10.5
18lymphoblastic leukemia10.5
19multiple myeloma10.4
20histiocytosis10.4
21myeloma10.4
22vasculitis10.4
23chronic neutrophilic leukemia10.4
24antiphospholipid syndrome10.3
25pyoderma gangrenosum10.3
26monocytic leukemia10.3
27pericardial effusion10.3
28polyneuropathy10.3
29purpura10.3
30pyoderma10.3
31endometrial stromal sarcoma10.2PDGFRB, CSF1
32bone marrow cancer10.2NRAS, FLT3
33pigmented villonodular synovitis10.2PDGFRB, CSF1
34porphyria cutanea tarda10.2
35hepatocellular carcinoma10.2
36mast cell disease10.2
37myeloperoxidase deficiency10.2
38ewing sarcoma10.2
39pyruvate kinase deficiency10.2
40keratitis10.2
41acute monocytic leukemia10.2
42chronic inflammatory demyelinating polyneuropathy10.2
43granuloma annulare10.2
44liver disease10.2
45myasthenia gravis10.2
46myelodysplastic myeloproliferative cancer10.2
47neutropenia10.2
48severe congenital neutropenia10.2
49skin disease10.2
50relapsing polychondritis10.2

Graphical network of the top 20 diseases related to Chronic Myelomonocytic Leukemia:



Diseases related to chronic myelomonocytic leukemia

Symptoms for Chronic Myelomonocytic Leukemia

About this section

Drugs & Therapeutics for Chronic Myelomonocytic Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Chronic Myelomonocytic Leukemia

Search NIH Clinical Center for Chronic Myelomonocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Myelomonocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myelomonocytic Leukemia:
Hemacord
Embryonic/Adult Cultured Cells Related to Chronic Myelomonocytic Leukemia:
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244

Genetic Tests for Chronic Myelomonocytic Leukemia

About this section

Anatomical Context for Chronic Myelomonocytic Leukemia

About this section

MalaCards organs/tissues related to Chronic Myelomonocytic Leukemia:

31
Bone, Bone marrow, Myeloid, Monocytes, Skin, Neutrophil, T cells, Kidney, Liver, Spleen, Brain, Small intestine, Colon, Adrenal gland, Breast, Testes, B cells

Animal Models for Chronic Myelomonocytic Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Chronic Myelomonocytic Leukemia:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4CSF1, NRAS, PDGFRB, ETV6, EZH2
2MP:00053808.4EZH2, ETV6, DNMT3A, PDGFRB, NRAS
3MP:00028738.4ETV6, TET2, EZH2, NRAS, PDGFRB
4MP:00020068.3TET2, NRAS, ETV6, FLT3, EZH2
5MP:00053858.1NRAS, PDGFRB, CSF1, ETV6, EZH2, TET2
6MP:00030128.0TET2, NRAS, CSF1, DNMT3A, ETV6, EZH2
7MP:00053767.5ETV6, FLT3, CSF1, DNMT3A, NRAS, PDGFRB
8MP:00053977.2ETV6, NRAS, PDGFRB, CSF1, ASXL1, FLT3
9MP:00053877.1NRAS, PDGFRB, ETV6, CSF1, ASXL1, FLT3
10MP:00053786.9EZH2, TET2, FLT3, ETV6, DNMT3A, CSF1
11MP:00053846.6PDGFRB, TET2, EZH2, FLT3, ASXL1, ETV6
12MP:00107686.6TET2, PDGFRB, NRAS, EZH2, FLT3, ASXL1

Publications for Chronic Myelomonocytic Leukemia

About this section

Articles related to Chronic Myelomonocytic Leukemia:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
Biological activities of RUNX1 mutants predict secondary acute leukemia transformation from chronic myelomonocytic leukemia and myelodysplastic syndromes. (25840971)
2015
2
Clinical manifestation of the SRSF2 gene mutation in Chinese patients with chronic myelomonocytic leukemia. (25533824)
2014
3
Stem cell transplant for juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. (25332531)
2014
4
Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia. (25498990)
2014
5
SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML. (23558523)
2013
6
Importance of genetics in the clinical management of chronic myelomonocytic leukemia. (23690427)
2013
7
Evolution of chronic myelomonocytic leukemia from refractory anemia: the unusual course of a myelodysplastic syndrome. (23826588)
2013
8
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management. (23963888)
2013
9
Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia. (23372164)
2013
10
Brain pseudo-tumoral inflammatory lesion associated with chronic myelomonocytic leukemia. (23475392)
2013
11
Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts. (23065512)
2013
12
Chronic myelomonocytic leukemia monocytes uniformly display a population of monocytes with CD11c underexpression. (24124148)
2013
13
Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia. (23307061)
2013
14
Chronic myelomonocytic leukemia presenting as relapsing thrombotic thrombocytopenic purpura. (23740594)
2013
15
Paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia. (24198985)
2013
16
A novel compound heterozygous HAX1 mutation in a Chinese patient with severe congenital neutropenia and chronic myelomonocytic leukemia transformation but without neurodevelopmental abnormalities. (22102707)
2012
17
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. (22395470)
2012
18
Incidence and survival of chronic myelomonocytic leukemia in Girona (Spain): a population-based study, 1993-2007. (22784713)
2012
19
Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations. (22415325)
2012
20
Therapeutic hotline: Primary cutaneous CD4 + small/medium-sized pleomorphic T cell lymphoma coexisting with myelodysplastic syndrome transforming into chronic myelomonocytic leukemia successfully treated with cyclophosphamide. (21054711)
2010
21
Abolishment of pleural effusion as the initial manifestation of chronic myelomonocytic leukemia without chemotherapy. (19039201)
2008
22
Chronic myelomonocytic leukemia. (18283784)
2008
23
Prognostic factors in myelodysplastic and myeloproliferative types of chronic myelomonocytic leukemia: a retrospective analysis of 83 patients from a single institution. (15257942)
2004
24
Gingival involvement in a patient with CD56+ chronic myelomonocytic leukemia. (15101735)
2004
25
Topoisomerase I inhibitors in the treatment of myelodysplastic syndromes and chronic myelomonocytic leukemia. (15068895)
2004
26
Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). (12750705)
2003
27
Chronic myelomonocytic leukemia. (14666928)
2003
28
Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients. (11806985)
2002
29
Autoimmune phenomena in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. (12533032)
2002
30
Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. (12384142)
2002
31
Classifying chronic myelomonocytic leukemia. (11533106)
2001
32
Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia. (10561358)
1999
33
Case 5-1998: bone marrow blasts in chronic myelomonocytic leukemia. (9643993)
1998
34
Spontaneous remission of juvenile chronic myelomonocytic leukemia in an infant with Noonan syndrome. (9149755)
1997
35
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. (8962143)
1996
36
Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant. (8756090)
1996
37
IL-4 stimulates the growth of chronic myelomonocytic leukemia cells (CMMoL) once leukemic transformation has occurred. (7596169)
1995
38
Chronic myelomonocytic leukemia following prolonged alkylating agent therapy for multiple myeloma. (7894029)
1994
39
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. (8168137)
1994
40
Long-term response to interferon-alpha in a patient with systemic mastocytosis and chronic myelomonocytic leukemia. (8042625)
1994
41
Cytogenetic evidence for extramedullary blast crisis with t(8;13)(q11;p11) in chronic myelomonocytic leukemia. (1292310)
1992
42
Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia. (2027297)
1991
43
Chronic myelomonocytic leukemia: clinical data, morphological features, and outcome in 56 patients. (2323647)
1990
44
Analysis of factors associated with short-term survival in chronic myelomonocytic leukemia. (2358210)
1990
45
11q23 abnormality and chronic myelomonocytic leukemia. (3422588)
1988
46
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
47
Translocation (1;7) in a case of secondary chronic myelomonocytic leukemia. (3466683)
1987
48
Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors. (6589029)
1984
49
Chronic myelomonocytic leukemia according to FAB classification: analysis of 35 cases. (6582939)
1984
50
Chronic myelomonocytic leukemia: light and electron microscopy of the bone marrow. (289428)
1979

Variations for Chronic Myelomonocytic Leukemia

About this section

Expression for genes affiliated with Chronic Myelomonocytic Leukemia

About this section
Search GEO for disease gene expression data for Chronic Myelomonocytic Leukemia.

Pathways for genes affiliated with Chronic Myelomonocytic Leukemia

About this section

Pathways related to Chronic Myelomonocytic Leukemia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PDGFRB, DNMT3A
29.6PDGFRB, CSF1
39.6CSF1, PDGFRB
4
Show member pathways
9.3CSF1, DNMT3A
5
Show member pathways
9.3RAN, NRAS, PDGFRB
69.3PDGFRB, NRAS, RAN
79.2NRAS, PDGFRB, CSF1
8
Show member pathways
9.2CSF1, PDGFRB, NRAS
9
Show member pathways
9.0NRAS, PDGFRB, FLT3
109.0NRAS, PDGFRB, FLT3
118.8EZH2, DNMT3A, PDGFRB, NRAS
12
Show member pathways
8.4FLT3, PDGFRB, NRAS, RAN
13
Show member pathways
8.3FLT3, CSF1, PDGFRB, NRAS
14
Show member pathways
8.3FLT3, CSF1, PDGFRB, NRAS
15
Show member pathways
8.3NRAS, PDGFRB, CSF1, FLT3

Compounds for genes affiliated with Chronic Myelomonocytic Leukemia

About this section
Sources:
44Novoseek, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Chronic Myelomonocytic Leukemia according to GeneCards Suite gene sharing:

(show all 22)
idCompoundScoreTop Affiliating Genes
1topotecan44 1110.7PDGFRB, RAN
2pkc 412449.7FLT3, PDGFRB
3ag-1296449.6PDGFRB, FLT3
4su5416449.6PDGFRB, FLT3
5sunitinib44 50 1111.6FLT3, PDGFRB
6s-adenosylhomocysteine44 2410.5DNMT3A, EZH2
7matrigel449.4PDGFRB, IL32, CSF1
8pixy321449.3FLT3, CSF1
9agar449.2PDGFRB, NRAS, ETV6, CSF1
10sorafenib44 50 1111.1PDGFRB, FLT3
11gp 130449.1PDGFRB, FLT3, CSF1
12mitoxantrone44 50 1111.0CSF1, FLT3
13tgf beta1449.0PDGFRB, CSF1, FLT3
14methylcellulose448.9FLT3, CSF1
15phosphotyrosine448.9FLT3, CSF1, PDGFRB
16rapamycin448.9FLT3, CSF1, PDGFRB
17imatinib44 50 1110.8CSF1, PDGFRB, FLT3, ETV6
18phosphatidylinositol448.4CSF1, FLT3, PDGFRB, RAN
19retinoic acid44 249.3PDGFRB, FLT3, EZH2, CSF1, ETV6
20oligonucleotide448.2RAN, NRAS, DNMT3A, FLT3, PDGFRB
21vegf448.0EZH2, FLT3, ETV6, IL32, CSF1, PDGFRB
22tyrosine447.5ETV6, FLT3, IL32, CSF1, PDGFRB, NRAS

GO Terms for genes affiliated with Chronic Myelomonocytic Leukemia

About this section

Biological processes related to Chronic Myelomonocytic Leukemia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of retinoic acid receptor signaling pathwayGO:00483879.7ASXL1, EZH2
2response to retinoic acidGO:00325269.6PDGFRB, ASXL1
3positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.4FLT3, PDGFRB
4positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.3PDGFRB, FLT3
5positive regulation of MAP kinase activityGO:00434069.1PDGFRB, FLT3, EZH2
6hemopoiesisGO:00300979.0CSF1, FLT3
7positive regulation of cell proliferationGO:00082848.5NRAS, PDGFRB, CSF1, FLT3

Molecular functions related to Chronic Myelomonocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase bindingGO:00435489.1PDGFRB, FLT3
2chromatin bindingGO:00036829.0RAN, DNMT3A, EZH2
3protein bindingGO:00055156.4RAN, TET2, EZH2, FLT3, ASXL1, ETV6

Sources for Chronic Myelomonocytic Leukemia

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet