MCID: CHR285
MIFTS: 48

Chronic Myelomonocytic Leukemia malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Chronic Myelomonocytic Leukemia

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Wikipedia:63 Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming... more...

MalaCards based summary: Chronic Myelomonocytic Leukemia, also known as leukemia, myelomonocytic, chronic, is related to myelodysplastic syndrome and systemic mastocytosis. An important gene associated with Chronic Myelomonocytic Leukemia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Validated targets of C-MYC transcriptional repression and Signaling events mediated by TCPTP. The compounds topotecan and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related mouse phenotypes are integument and embryogenesis.

Aliases & Classifications for Chronic Myelomonocytic Leukemia

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Sources:
30LifeMap Discovery®, 41NIH Rare Diseases, 47Orphanet, 60UMLS, 43Novoseek, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Chronic Myelomonocytic Leukemia, Aliases & Descriptions:

Name: Chronic Myelomonocytic Leukemia 30 41 47
Leukemia, Myelomonocytic, Chronic 41 60
 
Leukemia Myelomonocytic Chronic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

47
chronic myelomonocytic leukemia:
Age of onset: Adult


External Ids:

Orphanet47 98823
MESH via Orphanet34 D015477
ICD10 via Orphanet26 C93.1
UMLS via Orphanet61 C0023480
ICD1025 C93.1

Related Diseases for Chronic Myelomonocytic Leukemia

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Diseases in the Acute Myelomonocytic Leukemia family:

Leukemia, Juvenile Myelomonocytic chronic myelomonocytic leukemia

Diseases related to Chronic Myelomonocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1myelodysplastic syndrome31.9CSF1, NRAS
2systemic mastocytosis31.3TET2, PDGFRB
3myelofibrosis31.1PDGFRB, TET2, ASXL1
4leukemia, juvenile myelomonocytic31.1NRAS, FLT3
5myeloid leukemia31.0ETV6, FLT3, CSF1
6refractory anemia31.0CSF1, FLT3
7eosinophilia30.8PDGFRB, CSF1, ETV6
8acute myelomonocytic leukemia30.7ETV6, CSF1
9sarcoma30.5PDGFRB, CSF1, ETV6, NRAS
10acute leukemia30.5CSF1, ETV6, FLT3
11aplastic anemia30.3FLT3, CSF1
12polycythemia vera30.2TET2, FLT3, PDGFRB, ASXL1
13leukemia30.2PDGFRB, TET2, FLT3, RAN, EZH2, ASXL1
14breast cancer28.6EZH2, FLT3, ETV6, DNMT3A, CSF1, NRAS
15mastocytosis10.6
16chronic lymphocytic leukemia10.5
17thrombocytopenia10.5
18lymphoblastic leukemia10.5
19multiple myeloma10.4
20histiocytosis10.4
21myeloma10.4
22vasculitis10.4
23chronic neutrophilic leukemia10.4
24antiphospholipid syndrome10.3
25pyoderma gangrenosum10.3
26monocytic leukemia10.3
27pericardial effusion10.3
28polyneuropathy10.3
29purpura10.3
30pyoderma10.3
31endometrial stromal sarcoma10.2PDGFRB, CSF1
32bone marrow cancer10.2NRAS, FLT3
33pigmented villonodular synovitis10.2PDGFRB, CSF1
34porphyria cutanea tarda10.2
35hepatocellular carcinoma10.2
36mast cell disease10.2
37myeloperoxidase deficiency10.2
38ewing sarcoma10.2
39pyruvate kinase deficiency10.2
40keratitis10.2
41acute monocytic leukemia10.2
42chronic inflammatory demyelinating polyneuropathy10.2
43granuloma annulare10.2
44liver disease10.2
45myasthenia gravis10.2
46myelodysplastic myeloproliferative cancer10.2
47neutropenia10.2
48severe congenital neutropenia10.2
49skin disease10.2
50relapsing polychondritis10.2

Graphical network of the top 20 diseases related to Chronic Myelomonocytic Leukemia:



Diseases related to chronic myelomonocytic leukemia

Symptoms for Chronic Myelomonocytic Leukemia

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Drugs & Therapeutics for Chronic Myelomonocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Chronic Myelomonocytic Leukemia

Search NIH Clinical Center for Chronic Myelomonocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Myelomonocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myelomonocytic Leukemia:
Hemacord
Embryonic/Adult Cultured Cells Related to Chronic Myelomonocytic Leukemia:
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244

Genetic Tests for Chronic Myelomonocytic Leukemia

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Anatomical Context for Chronic Myelomonocytic Leukemia

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MalaCards organs/tissues related to Chronic Myelomonocytic Leukemia:

31
Bone, Bone marrow, Myeloid, Monocytes, Skin, Neutrophil, T cells, Kidney, Liver, Spleen, Brain, Small intestine, Colon, Adrenal gland, Breast, Testes, B cells

Animal Models for Chronic Myelomonocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Chronic Myelomonocytic Leukemia:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4CSF1, NRAS, PDGFRB, ETV6, EZH2
2MP:00053808.4EZH2, ETV6, DNMT3A, PDGFRB, NRAS
3MP:00028738.4ETV6, TET2, EZH2, NRAS, PDGFRB
4MP:00020068.3TET2, NRAS, ETV6, FLT3, EZH2
5MP:00053858.1NRAS, PDGFRB, CSF1, ETV6, EZH2, TET2
6MP:00030128.0TET2, NRAS, CSF1, DNMT3A, ETV6, EZH2
7MP:00053767.5ETV6, FLT3, CSF1, DNMT3A, NRAS, PDGFRB
8MP:00053977.2ETV6, NRAS, PDGFRB, CSF1, ASXL1, FLT3
9MP:00053877.1NRAS, PDGFRB, ETV6, CSF1, ASXL1, FLT3
10MP:00053786.9EZH2, TET2, FLT3, ETV6, DNMT3A, CSF1
11MP:00053846.6PDGFRB, TET2, EZH2, FLT3, ASXL1, ETV6
12MP:00107686.6TET2, PDGFRB, NRAS, EZH2, FLT3, ASXL1

Publications for Chronic Myelomonocytic Leukemia

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Articles related to Chronic Myelomonocytic Leukemia:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
Biological activities of RUNX1 mutants predict secondary acute leukemia transformation from chronic myelomonocytic leukemia and myelodysplastic syndromes. (25840971)
2015
2
Clinical manifestation of the SRSF2 gene mutation in Chinese patients with chronic myelomonocytic leukemia. (25533824)
2014
3
Stem cell transplant for juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. (25332531)
2014
4
Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia. (25498990)
2014
5
SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML. (23558523)
2013
6
Importance of genetics in the clinical management of chronic myelomonocytic leukemia. (23690427)
2013
7
Evolution of chronic myelomonocytic leukemia from refractory anemia: the unusual course of a myelodysplastic syndrome. (23826588)
2013
8
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management. (23963888)
2013
9
Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia. (23372164)
2013
10
Brain pseudo-tumoral inflammatory lesion associated with chronic myelomonocytic leukemia. (23475392)
2013
11
Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts. (23065512)
2013
12
Chronic myelomonocytic leukemia monocytes uniformly display a population of monocytes with CD11c underexpression. (24124148)
2013
13
Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia. (23307061)
2013
14
Chronic myelomonocytic leukemia presenting as relapsing thrombotic thrombocytopenic purpura. (23740594)
2013
15
Paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia. (24198985)
2013
16
A novel compound heterozygous HAX1 mutation in a Chinese patient with severe congenital neutropenia and chronic myelomonocytic leukemia transformation but without neurodevelopmental abnormalities. (22102707)
2012
17
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. (22395470)
2012
18
Incidence and survival of chronic myelomonocytic leukemia in Girona (Spain): a population-based study, 1993-2007. (22784713)
2012
19
Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations. (22415325)
2012
20
Therapeutic hotline: Primary cutaneous CD4 + small/medium-sized pleomorphic T cell lymphoma coexisting with myelodysplastic syndrome transforming into chronic myelomonocytic leukemia successfully treated with cyclophosphamide. (21054711)
2010
21
Abolishment of pleural effusion as the initial manifestation of chronic myelomonocytic leukemia without chemotherapy. (19039201)
2008
22
Chronic myelomonocytic leukemia. (18283784)
2008
23
Prognostic factors in myelodysplastic and myeloproliferative types of chronic myelomonocytic leukemia: a retrospective analysis of 83 patients from a single institution. (15257942)
2004
24
Gingival involvement in a patient with CD56+ chronic myelomonocytic leukemia. (15101735)
2004
25
Topoisomerase I inhibitors in the treatment of myelodysplastic syndromes and chronic myelomonocytic leukemia. (15068895)
2004
26
Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). (12750705)
2003
27
Chronic myelomonocytic leukemia. (14666928)
2003
28
Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients. (11806985)
2002
29
Autoimmune phenomena in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. (12533032)
2002
30
Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. (12384142)
2002
31
Classifying chronic myelomonocytic leukemia. (11533106)
2001
32
Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia. (10561358)
1999
33
Case 5-1998: bone marrow blasts in chronic myelomonocytic leukemia. (9643993)
1998
34
Spontaneous remission of juvenile chronic myelomonocytic leukemia in an infant with Noonan syndrome. (9149755)
1997
35
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. (8962143)
1996
36
Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant. (8756090)
1996
37
IL-4 stimulates the growth of chronic myelomonocytic leukemia cells (CMMoL) once leukemic transformation has occurred. (7596169)
1995
38
Chronic myelomonocytic leukemia following prolonged alkylating agent therapy for multiple myeloma. (7894029)
1994
39
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. (8168137)
1994
40
Long-term response to interferon-alpha in a patient with systemic mastocytosis and chronic myelomonocytic leukemia. (8042625)
1994
41
Cytogenetic evidence for extramedullary blast crisis with t(8;13)(q11;p11) in chronic myelomonocytic leukemia. (1292310)
1992
42
Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia. (2027297)
1991
43
Chronic myelomonocytic leukemia: clinical data, morphological features, and outcome in 56 patients. (2323647)
1990
44
Analysis of factors associated with short-term survival in chronic myelomonocytic leukemia. (2358210)
1990
45
11q23 abnormality and chronic myelomonocytic leukemia. (3422588)
1988
46
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
47
Translocation (1;7) in a case of secondary chronic myelomonocytic leukemia. (3466683)
1987
48
Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors. (6589029)
1984
49
Chronic myelomonocytic leukemia according to FAB classification: analysis of 35 cases. (6582939)
1984
50
Chronic myelomonocytic leukemia: light and electron microscopy of the bone marrow. (289428)
1979

Variations for Chronic Myelomonocytic Leukemia

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Expression for genes affiliated with Chronic Myelomonocytic Leukemia

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Search GEO for disease gene expression data for Chronic Myelomonocytic Leukemia.

Pathways for genes affiliated with Chronic Myelomonocytic Leukemia

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Pathways related to Chronic Myelomonocytic Leukemia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PDGFRB, DNMT3A
29.6PDGFRB, CSF1
39.6CSF1, PDGFRB
4
Show member pathways
9.3DNMT3A, CSF1
59.3NRAS, RAN, PDGFRB
6
Show member pathways
9.3RAN, PDGFRB, NRAS
79.2CSF1, PDGFRB, NRAS
8
Show member pathways
9.2CSF1, PDGFRB, NRAS
9
Show member pathways
9.0NRAS, FLT3, PDGFRB
109.0FLT3, PDGFRB, NRAS
118.8EZH2, DNMT3A, PDGFRB, NRAS
12
Show member pathways
8.4NRAS, PDGFRB, FLT3, RAN
13
Show member pathways
8.3FLT3, NRAS, CSF1, PDGFRB
14
Show member pathways
8.3FLT3, CSF1, PDGFRB, NRAS
15
Show member pathways
8.3CSF1, FLT3, PDGFRB, NRAS

Compounds for genes affiliated with Chronic Myelomonocytic Leukemia

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Sources:
43Novoseek, 12DrugBank, 49PharmGKB, 24HMDB
See all sources

Compounds related to Chronic Myelomonocytic Leukemia according to GeneCards Suite gene sharing:

(show all 22)
idCompoundScoreTop Affiliating Genes
1topotecan43 1210.7PDGFRB, RAN
2pkc 412439.7FLT3, PDGFRB
3ag-1296439.6PDGFRB, FLT3
4su5416439.6PDGFRB, FLT3
5sunitinib43 49 1211.6FLT3, PDGFRB
6s-adenosylhomocysteine43 2410.5DNMT3A, EZH2
7matrigel439.4PDGFRB, IL32, CSF1
8pixy321439.3FLT3, CSF1
9agar439.2PDGFRB, NRAS, ETV6, CSF1
10sorafenib43 49 1211.1PDGFRB, FLT3
11gp 130439.1PDGFRB, FLT3, CSF1
12mitoxantrone43 49 1211.0CSF1, FLT3
13tgf beta1439.0PDGFRB, CSF1, FLT3
14methylcellulose438.9FLT3, CSF1
15phosphotyrosine438.9FLT3, CSF1, PDGFRB
16rapamycin438.9FLT3, CSF1, PDGFRB
17imatinib43 49 1210.8CSF1, PDGFRB, FLT3, ETV6
18phosphatidylinositol438.4CSF1, FLT3, PDGFRB, RAN
19retinoic acid43 249.3PDGFRB, FLT3, EZH2, CSF1, ETV6
20oligonucleotide438.2RAN, NRAS, DNMT3A, FLT3, PDGFRB
21vegf438.0EZH2, FLT3, ETV6, IL32, CSF1, PDGFRB
22tyrosine437.5ETV6, FLT3, IL32, CSF1, PDGFRB, NRAS

GO Terms for genes affiliated with Chronic Myelomonocytic Leukemia

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Biological processes related to Chronic Myelomonocytic Leukemia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of retinoic acid receptor signaling pathwayGO:00483879.7ASXL1, EZH2
2response to retinoic acidGO:00325269.6ASXL1, PDGFRB
3positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.4PDGFRB, FLT3
4positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.3FLT3, PDGFRB
5positive regulation of MAP kinase activityGO:00434069.1PDGFRB, FLT3, EZH2
6hemopoiesisGO:00300979.0FLT3, CSF1
7positive regulation of cell proliferationGO:00082848.5NRAS, FLT3, CSF1, PDGFRB

Molecular functions related to Chronic Myelomonocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase bindingGO:00435489.1PDGFRB, FLT3
2chromatin bindingGO:00036829.0EZH2, DNMT3A, RAN
3protein bindingGO:00055156.4ETV6, ASXL1, EZH2, IL32, DNMT3A, PDGFRB

Products for genes affiliated with Chronic Myelomonocytic Leukemia

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Sources for Chronic Myelomonocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet