MCID: CHR285
MIFTS: 56

Chronic Myelomonocytic Leukemia malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Chronic Myelomonocytic Leukemia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming... more...

MalaCards: Chronic Myelomonocytic Leukemia, also known as leukemia, myelomonocytic, chronic, is related to leukemia and myelodysplastic syndromes. An important gene associated with Chronic Myelomonocytic Leukemia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Validated targets of C-MYC transcriptional repression and Signaling events mediated by TCPTP. The compounds topotecan and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related mouse phenotypes are integument and embryogenesis.

Aliases & Classifications for Chronic Myelomonocytic Leukemia

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44NIH Rare Diseases, 46Novoseek, 50Orphanet, 32LifeMap Discoveryā„¢, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

50
chronic myelomonocytic leukemia:
Age of onset: Adulthood


Aliases & Descriptions:

chronic myelomonocytic leukemia 44 50 32
leukemia, myelomonocytic, chronic 44 63
leukemia myelomonocytic chronic 46


External Ids:

ICD10 via Orphanet27 C93.1
SNOMED-CT via Orphanet60 127225006, 128831004
UMLS via Orphanet64 C0023480
MESH via Orphanet37 D015477
ICD1026 C93.1

Related Diseases for Chronic Myelomonocytic Leukemia

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18GeneCards, 19GeneDecks
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Diseases in the Juvenile Myelomonocytic Leukemia family:

Acute Myelomonocytic Leukemia chronic myelomonocytic leukemia

Diseases related to Chronic Myelomonocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.7TET2, EZH2, FLT3, ASXL1, ETV6, DNMT3A
2myelodysplastic syndromes31.1RAN, FLT3, ETV6, CSF1, PDGFRB, NRAS
3myeloid leukemia31.1FLT3, ETV6, CSF1
4juvenile myelomonocytic leukemia31.0NRAS, FLT3
5refractory anemia30.9CSF1, FLT3
6myelofibrosis30.9PDGFRB, ASXL1, TET2
7systemic mastocytosis30.8TET2, PDGFRB
8eosinophilia30.7PDGFRB, CSF1, ETV6
9sarcoma30.6NRAS, PDGFRB, CSF1, ETV6
10acute leukemia30.6CSF1, ETV6, FLT3
11chronic myeloid leukemia30.5FLT3, ETV6, PDGFRB, NRAS, RAN
12myeloproliferative disorder30.5RAN, PDGFRB, ETV6, FLT3
13acute myelomonocytic leukemia30.3CSF1, ETV6
14aplastic anemia30.2FLT3, CSF1
15polycythemia vera30.2TET2, FLT3, ASXL1, PDGFRB
16breast cancer29.9EZH2, FLT3, ETV6, IL32, DNMT3A, CSF1
17acute myeloid leukemia10.7
18mastocytosis10.5
19chronic lymphocytic leukemia10.5
20lymphoblastic leukemia10.5
21histiocytosis10.4
22vasculitis10.4
23antiphospholipid syndrome10.3
24pyoderma gangrenosum10.3
25monocytic leukemia10.3
26multiple myeloma10.3
27myeloma10.3
28pericardial effusion10.3
29polyneuropathy10.3
30purpura10.3
31pyoderma10.3
32generalized eruptive histiocytosis10.3
33cardiac tamponade10.2
34acute monocytic leukemia10.2
35relapsing polychondritis10.2
36pure red-cell aplasia10.2
37factor xiii deficiency10.2
38thrombotic thrombocytopenic purpura10.2
39leukostasis10.2
40aortitis10.2
41follicular mucinosis10.2
42malignant histiocytosis10.2
43myeloid sarcoma10.2
44porphyria cutanea tarda10.2
45fanconi's anemia10.2
46diphtheria10.2
47folliculitis10.2
48noonan syndrome10.2
49severe congenital neutropenia10.2
50calciphylaxis10.2

Graphical network of the top 20 diseases related to Chronic Myelomonocytic Leukemia:



Diseases related to chronic myelomonocytic leukemia

Symptoms for Chronic Myelomonocytic Leukemia

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Drugs & Therapeutics for Chronic Myelomonocytic Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Myelomonocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Chronic Myelomonocytic Leukemia

Search NIH Clinical Center for Chronic Myelomonocytic Leukemia

Search CenterWatch for Chronic Myelomonocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Myelomonocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myelomonocytic Leukemia:
Hemacord
Embryonic/Adult Cultured Cells Related to Chronic Myelomonocytic Leukemia:
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244

Genetic Tests for Chronic Myelomonocytic Leukemia

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Anatomical Context for Chronic Myelomonocytic Leukemia

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34MalaCards
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MalaCards organs/tissues related to Chronic Myelomonocytic Leukemia:

34
Bone, Bone marrow, Myeloid, Monocytes, Skin, T cells, Kidney, Liver, B cells, Brain, Breast, Colon, Spleen, Testes, Adrenal gland

Animal Models for Chronic Myelomonocytic Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chronic Myelomonocytic Leukemia:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4CSF1, NRAS, PDGFRB, ETV6, EZH2
2MP:00053808.4EZH2, ETV6, DNMT3A, PDGFRB, NRAS
3MP:00028738.4ETV6, TET2, EZH2, NRAS, PDGFRB
4MP:00020068.3TET2, NRAS, ETV6, FLT3, EZH2
5MP:00053858.1NRAS, PDGFRB, CSF1, ETV6, EZH2, TET2
6MP:00030128.0TET2, NRAS, CSF1, DNMT3A, ETV6, EZH2
7MP:00053767.5ETV6, FLT3, CSF1, DNMT3A, NRAS, PDGFRB
8MP:00053977.2ETV6, NRAS, PDGFRB, CSF1, ASXL1, FLT3
9MP:00053877.1NRAS, PDGFRB, ETV6, CSF1, ASXL1, FLT3
10MP:00053786.9EZH2, TET2, FLT3, ETV6, DNMT3A, CSF1
11MP:00053846.6PDGFRB, TET2, EZH2, FLT3, ASXL1, ETV6
12MP:00107686.6TET2, PDGFRB, NRAS, EZH2, FLT3, ASXL1

Publications for Chronic Myelomonocytic Leukemia

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53PubMed
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Articles related to Chronic Myelomonocytic Leukemia:

(show top 50)    (show all 395)
idTitleAuthorsYear
1
SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML. (23558523)
2013
2
Importance of genetics in the clinical management of chronic myelomonocytic leukemia. (23690427)
2013
3
Evolution of chronic myelomonocytic leukemia from refractory anemia: the unusual course of a myelodysplastic syndrome. (23826588)
2013
4
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management. (23963888)
2013
5
Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia. (23372164)
2013
6
Brain pseudo-tumoral inflammatory lesion associated with chronic myelomonocytic leukemia. (23475392)
2013
7
Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts. (23065512)
2013
8
Chronic myelomonocytic leukemia monocytes uniformly display a population of monocytes with CD11c underexpression. (24124148)
2013
9
Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia. (23307061)
2013
10
Chronic myelomonocytic leukemia presenting as relapsing thrombotic thrombocytopenic purpura. (23740594)
2013
11
Paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia. (24198985)
2013
12
A novel compound heterozygous HAX1 mutation in a Chinese patient with severe congenital neutropenia and chronic myelomonocytic leukemia transformation but without neurodevelopmental abnormalities. (22102707)
2012
13
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. (22395470)
2012
14
Incidence and survival of chronic myelomonocytic leukemia in Girona (Spain): a population-based study, 1993-2007. (22784713)
2012
15
Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations. (22415325)
2012
16
Therapeutic hotline: Primary cutaneous CD4 + small/medium-sized pleomorphic T cell lymphoma coexisting with myelodysplastic syndrome transforming into chronic myelomonocytic leukemia successfully treated with cyclophosphamide. (21054711)
2010
17
Abolishment of pleural effusion as the initial manifestation of chronic myelomonocytic leukemia without chemotherapy. (19039201)
2008
18
Chronic myelomonocytic leukemia. (18283784)
2008
19
Prognostic factors and risk assessment in chronic myelomonocytic leukemia: validation study of the M.D. Anderson Prognostic Scoring System. (17577778)
2007
20
Prognostic factors in myelodysplastic and myeloproliferative types of chronic myelomonocytic leukemia: a retrospective analysis of 83 patients from a single institution. (15257942)
2004
21
Gingival involvement in a patient with CD56+ chronic myelomonocytic leukemia. (15101735)
2004
22
Topoisomerase I inhibitors in the treatment of myelodysplastic syndromes and chronic myelomonocytic leukemia. (15068895)
2004
23
Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). (12750705)
2003
24
Chronic myelomonocytic leukemia. (14666928)
2003
25
Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients. (11806985)
2002
26
Autoimmune phenomena in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. (12533032)
2002
27
Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. (12384142)
2002
28
Chronic myelomonocytic leukemia. (12057067)
2002
29
Classifying chronic myelomonocytic leukemia. (11533106)
2001
30
Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia. (10561358)
1999
31
Case 5-1998: bone marrow blasts in chronic myelomonocytic leukemia. (9643993)
1998
32
Spontaneous remission of juvenile chronic myelomonocytic leukemia in an infant with Noonan syndrome. (9149755)
1997
33
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. (8962143)
1996
34
Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant. (8756090)
1996
35
IL-4 stimulates the growth of chronic myelomonocytic leukemia cells (CMMoL) once leukemic transformation has occurred. (7596169)
1995
36
Chronic myelomonocytic leukemia following prolonged alkylating agent therapy for multiple myeloma. (7894029)
1994
37
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. (8168137)
1994
38
Long-term response to interferon-alpha in a patient with systemic mastocytosis and chronic myelomonocytic leukemia. (8042625)
1994
39
Cytogenetic evidence for extramedullary blast crisis with t(8;13)(q11;p11) in chronic myelomonocytic leukemia. (1292310)
1992
40
Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia. (2027297)
1991
41
Chronic myelomonocytic leukemia: clinical data, morphological features, and outcome in 56 patients. (2323647)
1990
42
Analysis of factors associated with short-term survival in chronic myelomonocytic leukemia. (2358210)
1990
43
11q23 abnormality and chronic myelomonocytic leukemia. (3422588)
1988
44
Chronic myelomonocytic leukemia and primary SjAPgren's syndrome. (3165742)
1988
45
Significance and correlations of molecular analysis results in patients with Philadelphia chromosome-negative chronic myelogenous leukemia and chronic myelomonocytic leukemia. (3189367)
1988
46
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
47
Translocation (1;7) in a case of secondary chronic myelomonocytic leukemia. (3466683)
1987
48
Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors. (6589029)
1984
49
Chronic myelomonocytic leukemia according to FAB classification: analysis of 35 cases. (6582939)
1984
50
Chronic myelomonocytic leukemia: light and electron microscopy of the bone marrow. (289428)
1979

Variations for Chronic Myelomonocytic Leukemia

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Expression for genes affiliated with Chronic Myelomonocytic Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Myelomonocytic Leukemia

Search GEO for disease gene expression data for Chronic Myelomonocytic Leukemia.

Pathways for genes affiliated with Chronic Myelomonocytic Leukemia

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51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 52PharmGKB, 62Tocris Bioscience
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Pathways related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PDGFRB, DNMT3A
29.6PDGFRB, CSF1
39.6CSF1, PDGFRB
4
Show member pathways
9.3DNMT3A, CSF1
59.3NRAS, RAN, PDGFRB
6
Show member pathways
9.3RAN, PDGFRB, NRAS
79.2CSF1, PDGFRB, NRAS
8
Show member pathways
9.2CSF1, PDGFRB, NRAS
9
Show member pathways
9.0NRAS, FLT3, PDGFRB
109.0FLT3, PDGFRB, NRAS
118.8EZH2, DNMT3A, PDGFRB, NRAS
12
Show member pathways
8.4NRAS, PDGFRB, FLT3, RAN
13
Show member pathways
8.3FLT3, NRAS, CSF1, PDGFRB
14
Show member pathways
8.3FLT3, CSF1, PDGFRB, NRAS
15
Show member pathways
8.3CSF1, FLT3, PDGFRB, NRAS

Compounds for genes affiliated with Chronic Myelomonocytic Leukemia

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46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1topotecan46 1210.7PDGFRB, RAN
2pkc 412469.7PDGFRB, FLT3
3ag-1296469.6PDGFRB, FLT3
4su5416469.6FLT3, PDGFRB
5sunitinib46 52 1211.6PDGFRB, FLT3
6s-adenosylhomocysteine46 2510.5DNMT3A, EZH2
7matrigel469.4PDGFRB, CSF1, IL32
8pixy321469.3FLT3, CSF1
9agar469.2ETV6, CSF1, PDGFRB, NRAS
10sorafenib46 52 1211.1PDGFRB, FLT3
11gp 130469.1FLT3, CSF1, PDGFRB
12mitoxantrone46 52 1211.0CSF1, FLT3
13tgf beta1469.0PDGFRB, CSF1, FLT3
14methylcellulose468.9CSF1, FLT3
15phosphotyrosine468.9PDGFRB, CSF1, FLT3
16rapamycin468.9PDGFRB, CSF1, FLT3
17imatinib46 52 1210.8PDGFRB, CSF1, ETV6, FLT3
18phosphatidylinositol468.4FLT3, CSF1, PDGFRB, RAN
19retinoic acid46 259.3PDGFRB, CSF1, ETV6, FLT3, EZH2
20oligonucleotide468.2RAN, NRAS, PDGFRB, DNMT3A, FLT3
21vegf468.0PDGFRB, CSF1, IL32, ETV6, FLT3, EZH2
22tyrosine467.5FLT3, ETV6, IL32, CSF1, PDGFRB, NRAS

GO Terms for genes affiliated with Chronic Myelomonocytic Leukemia

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17Gene Ontology
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Biological processes related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of retinoic acid receptor signaling pathwayGO:0483879.7ASXL1, EZH2
2response to retinoic acidGO:0325269.6PDGFRB, ASXL1
3positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.4FLT3, PDGFRB
4positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.3PDGFRB, FLT3
5positive regulation of MAP kinase activityGO:0434069.1PDGFRB, FLT3, EZH2
6hemopoiesisGO:0300979.0CSF1, FLT3
7positive regulation of cell proliferationGO:0082848.5NRAS, PDGFRB, CSF1, FLT3

Molecular functions related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase bindingGO:0435489.1PDGFRB, FLT3
2chromatin bindingGO:0036829.0RAN, DNMT3A, EZH2
3protein bindingGO:0055156.4RAN, TET2, EZH2, FLT3, ASXL1, ETV6

Products for genes affiliated with Chronic Myelomonocytic Leukemia

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  • Antibodies
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  • Antibodies

Sources for Chronic Myelomonocytic Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet