MCID: CHR285
MIFTS: 56

Chronic Myelomonocytic Leukemia malady

Genetic diseases, Rare diseases, Blood diseases, Cancer diseases categories
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Summaries for Chronic Myelomonocytic Leukemia

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Wikipedia:65 Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming... more...

MalaCards based summary: Chronic Myelomonocytic Leukemia, also known as leukemia, myelomonocytic, chronic, is related to juvenile myelomonocytic leukemia and systemic mastocytosis. An important gene associated with Chronic Myelomonocytic Leukemia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Validated targets of C-MYC transcriptional repression and Signaling events mediated by TCPTP. The compounds topotecan and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related mouse phenotypes are integument and embryogenesis.

Aliases & Classifications for Chronic Myelomonocytic Leukemia

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Sources:
30LifeMap Discovery®, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 44Novoseek, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Chronic Myelomonocytic Leukemia, Aliases & Descriptions:

Name: Chronic Myelomonocytic Leukemia 30 42 48
Leukemia, Myelomonocytic, Chronic 42 62
 
Leukemia Myelomonocytic Chronic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
chronic myelomonocytic leukemia:
Age of onset: Adulthood


External Ids:

MESH via Orphanet35 D015477
ICD10 via Orphanet26 C93.1
UMLS via Orphanet63 C0023480

Related Diseases for Chronic Myelomonocytic Leukemia

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Diseases in the Juvenile Myelomonocytic Leukemia family:

chronic myelomonocytic leukemia Acute Myelomonocytic Leukemia

Diseases related to Chronic Myelomonocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile myelomonocytic leukemia31.3NRAS, FLT3
2systemic mastocytosis31.3TET2, PDGFRB
3myelofibrosis31.1PDGFRB, ASXL1, TET2
4refractory anemia31.0CSF1, FLT3
5myeloid leukemia31.0FLT3, ETV6, CSF1
6eosinophilia30.7PDGFRB, CSF1, ETV6
7acute myelomonocytic leukemia30.7CSF1, ETV6
8sarcoma30.5NRAS, PDGFRB, CSF1, ETV6
9acute leukemia30.4CSF1, ETV6, FLT3
10myelodysplastic syndromes30.3RAN, FLT3, ETV6, CSF1, PDGFRB, NRAS
11acute lymphoblastic leukemia30.3RAN, ETV6, FLT3
12acute promyelocytic leukemia30.2FLT3, CSF1, NRAS
13aplastic anemia30.2FLT3, CSF1
14polycythemia vera30.2TET2, FLT3, ASXL1, PDGFRB
15leukemia30.2TET2, EZH2, FLT3, ASXL1, ETV6, DNMT3A
16chronic myeloid leukemia30.0FLT3, ETV6, PDGFRB, NRAS, RAN
17pdgfrb-associated chronic eosinophilic leukemia29.9FLT3, ETV6, CSF1, PDGFRB
18breast cancer28.6EZH2, FLT3, ETV6, IL32, DNMT3A, CSF1
19acute myeloid leukemia10.8
20mastocytosis10.6
21chronic lymphocytic leukemia10.5
22lymphoblastic leukemia10.5
23multiple myeloma10.4
24thrombocytopenia10.4
25histiocytosis10.4
26myeloma10.4
27vasculitis10.4
28myelodysplastic syndrome, somatic10.4TET2, ASXL1
29antiphospholipid syndrome10.3
30pyoderma gangrenosum10.3
31monocytic leukemia10.3
32pericardial effusion10.3
33polyneuropathy10.3
34purpura10.3
35pyoderma10.3
36chronic neutrophilic leukemia10.3
37generalized eruptive histiocytosis10.3
38endometrial stromal sarcoma10.2PDGFRB, CSF1
39pigmented villonodular synovitis10.2CSF1, PDGFRB
40bone marrow cancer10.2FLT3, PDGFRB
41acute monocytic leukemia10.2
42chronic inflammatory demyelinating polyneuropathy10.2
43fanconi's anemia10.2
44gastric cancer10.2
45granuloma annulare10.2
46hepatocellular carcinoma10.2
47liver disease10.2
48myasthenia gravis10.2
49myelodysplastic myeloproliferative cancer10.2
50neutropenia10.2

Graphical network of the top 20 diseases related to Chronic Myelomonocytic Leukemia:



Diseases related to chronic myelomonocytic leukemia

Symptoms for Chronic Myelomonocytic Leukemia

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Drugs & Therapeutics for Chronic Myelomonocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Chronic Myelomonocytic Leukemia

Search NIH Clinical Center for Chronic Myelomonocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Myelomonocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myelomonocytic Leukemia:
Hemacord
Embryonic/Adult Cultured Cells Related to Chronic Myelomonocytic Leukemia:
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244

Genetic Tests for Chronic Myelomonocytic Leukemia

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Anatomical Context for Chronic Myelomonocytic Leukemia

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MalaCards organs/tissues related to Chronic Myelomonocytic Leukemia:

32
Bone, Bone marrow, Myeloid, Monocytes, Skin, Neutrophil, T cells, Kidney, Liver, Spleen, Brain, Small intestine, Colon, Adrenal gland, Breast, Testes, B cells

Animal Models for Chronic Myelomonocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Chronic Myelomonocytic Leukemia:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4CSF1, NRAS, PDGFRB, ETV6, EZH2
2MP:00053808.4EZH2, ETV6, DNMT3A, PDGFRB, NRAS
3MP:00028738.4ETV6, TET2, EZH2, NRAS, PDGFRB
4MP:00020068.3TET2, NRAS, ETV6, FLT3, EZH2
5MP:00053858.1NRAS, PDGFRB, CSF1, ETV6, EZH2, TET2
6MP:00030128.0TET2, NRAS, CSF1, DNMT3A, ETV6, EZH2
7MP:00053767.5ETV6, FLT3, CSF1, DNMT3A, NRAS, PDGFRB
8MP:00053977.2ETV6, NRAS, PDGFRB, CSF1, ASXL1, FLT3
9MP:00053877.1NRAS, PDGFRB, ETV6, CSF1, ASXL1, FLT3
10MP:00053786.9EZH2, TET2, FLT3, ETV6, DNMT3A, CSF1
11MP:00053846.6PDGFRB, TET2, EZH2, FLT3, ASXL1, ETV6
12MP:00107686.6TET2, PDGFRB, NRAS, EZH2, FLT3, ASXL1

Publications for Chronic Myelomonocytic Leukemia

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Articles related to Chronic Myelomonocytic Leukemia:

(show top 50)    (show all 412)
idTitleAuthorsYear
1
Stem cell transplant for juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. (25332531)
2014
2
SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML. (23558523)
2013
3
Importance of genetics in the clinical management of chronic myelomonocytic leukemia. (23690427)
2013
4
Evolution of chronic myelomonocytic leukemia from refractory anemia: the unusual course of a myelodysplastic syndrome. (23826588)
2013
5
Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management. (23963888)
2013
6
Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia. (23372164)
2013
7
Brain pseudo-tumoral inflammatory lesion associated with chronic myelomonocytic leukemia. (23475392)
2013
8
Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts. (23065512)
2013
9
Chronic myelomonocytic leukemia monocytes uniformly display a population of monocytes with CD11c underexpression. (24124148)
2013
10
Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia. (23307061)
2013
11
Chronic myelomonocytic leukemia presenting as relapsing thrombotic thrombocytopenic purpura. (23740594)
2013
12
Paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia. (24198985)
2013
13
A novel compound heterozygous HAX1 mutation in a Chinese patient with severe congenital neutropenia and chronic myelomonocytic leukemia transformation but without neurodevelopmental abnormalities. (22102707)
2012
14
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. (22395470)
2012
15
Incidence and survival of chronic myelomonocytic leukemia in Girona (Spain): a population-based study, 1993-2007. (22784713)
2012
16
Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations. (22415325)
2012
17
Therapeutic hotline: Primary cutaneous CD4 + small/medium-sized pleomorphic T cell lymphoma coexisting with myelodysplastic syndrome transforming into chronic myelomonocytic leukemia successfully treated with cyclophosphamide. (21054711)
2010
18
Abolishment of pleural effusion as the initial manifestation of chronic myelomonocytic leukemia without chemotherapy. (19039201)
2008
19
Chronic myelomonocytic leukemia. (18283784)
2008
20
Prognostic factors and risk assessment in chronic myelomonocytic leukemia: validation study of the M.D. Anderson Prognostic Scoring System. (17577778)
2007
21
Prognostic factors in myelodysplastic and myeloproliferative types of chronic myelomonocytic leukemia: a retrospective analysis of 83 patients from a single institution. (15257942)
2004
22
Gingival involvement in a patient with CD56+ chronic myelomonocytic leukemia. (15101735)
2004
23
Topoisomerase I inhibitors in the treatment of myelodysplastic syndromes and chronic myelomonocytic leukemia. (15068895)
2004
24
Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). (12750705)
2003
25
Chronic myelomonocytic leukemia. (14666928)
2003
26
Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients. (11806985)
2002
27
Autoimmune phenomena in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. (12533032)
2002
28
Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. (12384142)
2002
29
Chronic myelomonocytic leukemia. (12057067)
2002
30
Classifying chronic myelomonocytic leukemia. (11533106)
2001
31
Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia. (10561358)
1999
32
Case 5-1998: bone marrow blasts in chronic myelomonocytic leukemia. (9643993)
1998
33
Spontaneous remission of juvenile chronic myelomonocytic leukemia in an infant with Noonan syndrome. (9149755)
1997
34
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. (8962143)
1996
35
Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant. (8756090)
1996
36
Chronic myelomonocytic leukemia following prolonged alkylating agent therapy for multiple myeloma. (7894029)
1994
37
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. (8168137)
1994
38
Long-term response to interferon-alpha in a patient with systemic mastocytosis and chronic myelomonocytic leukemia. (8042625)
1994
39
Cytogenetic evidence for extramedullary blast crisis with t(8;13)(q11;p11) in chronic myelomonocytic leukemia. (1292310)
1992
40
Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia. (2027297)
1991
41
Chronic myelomonocytic leukemia: clinical data, morphological features, and outcome in 56 patients. (2323647)
1990
42
Analysis of factors associated with short-term survival in chronic myelomonocytic leukemia. (2358210)
1990
43
11q23 abnormality and chronic myelomonocytic leukemia. (3422588)
1988
44
Chronic myelomonocytic leukemia and primary SjAPgren's syndrome. (3165742)
1988
45
Significance and correlations of molecular analysis results in patients with Philadelphia chromosome-negative chronic myelogenous leukemia and chronic myelomonocytic leukemia. (3189367)
1988
46
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
47
Translocation (1;7) in a case of secondary chronic myelomonocytic leukemia. (3466683)
1987
48
Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors. (6589029)
1984
49
Chronic myelomonocytic leukemia according to FAB classification: analysis of 35 cases. (6582939)
1984
50
Chronic myelomonocytic leukemia: light and electron microscopy of the bone marrow. (289428)
1979

Variations for Chronic Myelomonocytic Leukemia

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Expression for genes affiliated with Chronic Myelomonocytic Leukemia

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Expression patterns in normal tissues for genes affiliated with Chronic Myelomonocytic Leukemia

Search GEO for disease gene expression data for Chronic Myelomonocytic Leukemia.

Pathways for genes affiliated with Chronic Myelomonocytic Leukemia

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Pathways related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PDGFRB, DNMT3A
29.6PDGFRB, CSF1
39.6CSF1, PDGFRB
4
Show member pathways
9.3CSF1, DNMT3A
5
Show member pathways
9.3RAN, NRAS, PDGFRB
69.3PDGFRB, NRAS, RAN
79.2NRAS, PDGFRB, CSF1
8
Show member pathways
9.2CSF1, PDGFRB, NRAS
9
Show member pathways
9.0NRAS, PDGFRB, FLT3
109.0NRAS, PDGFRB, FLT3
118.8EZH2, DNMT3A, PDGFRB, NRAS
12
Show member pathways
8.4FLT3, PDGFRB, NRAS, RAN
13
Show member pathways
8.3FLT3, CSF1, PDGFRB, NRAS
14
Show member pathways
8.3FLT3, CSF1, PDGFRB, NRAS
15
Show member pathways
8.3NRAS, PDGFRB, CSF1, FLT3

Compounds for genes affiliated with Chronic Myelomonocytic Leukemia

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Sources:
44Novoseek, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1topotecan44 1110.7PDGFRB, RAN
2pkc 412449.7PDGFRB, FLT3
3ag-1296449.6PDGFRB, FLT3
4su5416449.6FLT3, PDGFRB
5sunitinib44 50 1111.6PDGFRB, FLT3
6s-adenosylhomocysteine44 2410.5DNMT3A, EZH2
7matrigel449.4PDGFRB, CSF1, IL32
8pixy321449.3FLT3, CSF1
9agar449.2ETV6, CSF1, PDGFRB, NRAS
10sorafenib44 50 1111.1PDGFRB, FLT3
11gp 130449.1FLT3, CSF1, PDGFRB
12mitoxantrone44 50 1111.0CSF1, FLT3
13tgf beta1449.0PDGFRB, CSF1, FLT3
14methylcellulose448.9CSF1, FLT3
15phosphotyrosine448.9PDGFRB, CSF1, FLT3
16rapamycin448.9PDGFRB, CSF1, FLT3
17imatinib44 50 1110.8PDGFRB, CSF1, ETV6, FLT3
18phosphatidylinositol448.4FLT3, CSF1, PDGFRB, RAN
19retinoic acid44 249.3PDGFRB, CSF1, ETV6, FLT3, EZH2
20oligonucleotide448.2RAN, NRAS, PDGFRB, DNMT3A, FLT3
21vegf448.0PDGFRB, CSF1, IL32, ETV6, FLT3, EZH2
22tyrosine447.5FLT3, ETV6, IL32, CSF1, PDGFRB, NRAS

GO Terms for genes affiliated with Chronic Myelomonocytic Leukemia

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Biological processes related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of retinoic acid receptor signaling pathwayGO:0483879.7ASXL1, EZH2
2response to retinoic acidGO:0325269.6PDGFRB, ASXL1
3positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.4FLT3, PDGFRB
4positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.3PDGFRB, FLT3
5positive regulation of MAP kinase activityGO:0434069.1PDGFRB, FLT3, EZH2
6hemopoiesisGO:0300979.0CSF1, FLT3
7positive regulation of cell proliferationGO:0082848.5NRAS, PDGFRB, CSF1, FLT3

Molecular functions related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase bindingGO:0435489.1PDGFRB, FLT3
2chromatin bindingGO:0036829.0EZH2, DNMT3A, RAN
3protein bindingGO:0055156.4ETV6, ASXL1, EZH2, IL32, DNMT3A, PDGFRB

Products for genes affiliated with Chronic Myelomonocytic Leukemia

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Sources for Chronic Myelomonocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet