MCID: CHR285
MIFTS: 46

Chronic Myelomonocytic Leukemia malady

Cancer diseases, Blood diseases categories

Summaries for Chronic Myelomonocytic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming... more...

MalaCards: Chronic Myelomonocytic Leukemia, also known as leukemia, myelomonocytic, chronic, is related to leukemia and acute leukemia. An important gene associated with Chronic Myelomonocytic Leukemia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are LDL Oxidation in Atherogenesis and Alpha-defensins. The compounds pixy321 and molgramostim have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and myeloid, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Chronic Myelomonocytic Leukemia

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
chronic myelomonocytic leukemia:
Age of onset: Adulthood


Aliases & Descriptions:

chronic myelomonocytic leukemia 42 48 30
leukemia, myelomonocytic, chronic 42 60
leukemia myelomonocytic chronic 44


External Ids:

ICD10 via Orphanet26 C93.1
SNOMED-CT via Orphanet57 127225006, 128831004
UMLS via Orphanet61 C0023480
MESH via Orphanet35 D015477
ICD1025 C93.1

Related Diseases for Chronic Myelomonocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Juvenile Myelomonocytic Leukemia family:

Acute Myelomonocytic Leukemia chronic myelomonocytic leukemia

Diseases related to Chronic Myelomonocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.1MPO, NRAS, DNMT3A, ETV6, EZH2, HOXA9
2acute leukemia31.3CSF2, CSF1, GATA2, FLT3, TOP1, MPO
3chronic myeloid leukemia31.2PDGFRB, CSF2, GATA2, FLT3, MPO, NRAS
4myeloid leukemia31.2CSF2, CSF1, GATA2, FLT3, TOP1, MPO
5monocytic leukemia31.0CSF1, CSF2
6juvenile myelomonocytic leukemia31.0CSF2, FLT3, NRAS
7myelofibrosis30.7ASXL1, TET2, PDGFRB
8systemic mastocytosis30.6PDGFRB, TET2
9eosinophilia30.6PDGFRB, CSF2, CSF1, MPO, ETV6
10chronic myeloproliferative disease30.5PDGFRB, FLT3
11sarcoma30.5PDGFRB, CSF1, TOP1, NRAS, ETV6
12acute lymphocytic leukemia30.5CSF2, GATA2, FLT3, TOP1, MPO, ETV6
13acute monocytic leukemia30.4MPO, CSF1
14myeloma30.4CSF2, CSF1
15polycythemia vera30.2PDGFRB, FLT3, TET2, ASXL1
16adenocarcinoma30.2TOP1, PDGFRB
17hepatocellular carcinoma30.2IL32, EZH2, DNMT3A
18myeloid sarcoma30.2MPO
19aplastic anemia30.2CSF2, CSF1, GATA2, FLT3
20neutropenia30.2CSF2, CSF1, TOP1, MPO
21breast cancer30.2CSF2, CSF1, GATA2, FLT3, TOP1, DEFA1
22chronic monocytic leukemia10.7
23acute myeloid leukemia10.7
24chronic lymphocytic leukemia10.6
25lymphoblastic leukemia10.5
26testicular leukemia10.4
27childhood leukemia10.4
28histiocytosis10.4
29sideroblastic anemia10.4
30t-cell leukemia10.4
31vasculitis10.4
32antiphospholipid syndrome10.3
33mast-cell leukemia10.3
34pyoderma gangrenosum10.3
35adult syndrome10.3
36chronic polyneuropathy10.3
37liver disease10.3
38multiple myeloma10.3
39pericardial effusion10.3
40polyneuropathy10.3
41purpura10.3
42pyoderma10.3
43lymphoid leukemia10.1
44cardiac tamponade10.1
45pure red-cell aplasia10.1
46relapsing polychondritis10.1
47porphyria cutanea tarda10.1
48fanconi's anemia10.1
49diphtheria10.1
50subacute leukemia10.1

Graphical network of the top 20 diseases related to Chronic Myelomonocytic Leukemia:



Diseases related to chronic myelomonocytic leukemia

Clinical Features for Chronic Myelomonocytic Leukemia

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Drugs & Therapeutics for Chronic Myelomonocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Myelomonocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Chronic Myelomonocytic Leukemia

Search NIH Clinical Center for Chronic Myelomonocytic Leukemia

Search CenterWatch for Chronic Myelomonocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Myelomonocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myelomonocytic Leukemia:
Hemacord
Embryonic/Adult Cultured Cells Related to Chronic Myelomonocytic Leukemia:
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244

Genetic Tests for Chronic Myelomonocytic Leukemia

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Anatomical Context for Chronic Myelomonocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Chronic Myelomonocytic Leukemia:

32
Bone marrow, Bone, Myeloid, Monocytes

Animal Models for Chronic Myelomonocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chronic Myelomonocytic Leukemia:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.1CSF2, FLT3, NRAS, HIP1, ETV6, EZH2
2MP:001077110.0NRAS, ETV6, EZH2, HOXA9
3MP:000537910.0PDGFRB, CSF2, CSF1, GATA2, DNMT3A, ETV6
4MP:00028739.9GATA2, NRAS, HIP1, ETV6, EZH2, TET2
5MP:00053859.8PDGFRB, CSF2, CSF1, GATA2, MPO, NRAS
6MP:00030129.7CSF1, NRAS, DNMT3A, ETV6, EZH2, TET2
7MP:00053849.7FLT3, GATA2, CSF1, CSF2, PDGFRB, NRAS
8MP:00053879.7PDGFRB, CSF2, CSF1, FLT3, MPO, NRAS
9MP:00053789.6FLT3, GATA2, CSF1, CSF2, PDGFRB, NRAS
10MP:00053769.6PDGFRB, CSF2, CSF1, GATA2, FLT3, MPO
11MP:00053979.6ASXL1, PDGFRB, CSF2, CSF1, GATA2, FLT3
12MP:00107689.6TOP1, FLT3, GATA2, CSF1, CSF2, PDGFRB

Publications for Chronic Myelomonocytic Leukemia

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Genetic Variations for Chronic Myelomonocytic Leukemia

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Expression for genes affiliated with Chronic Myelomonocytic Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Myelomonocytic Leukemia

Search GEO for disease gene expression data for Chronic Myelomonocytic Leukemia.

Pathways for genes affiliated with Chronic Myelomonocytic Leukemia

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Sources:
51QIAGEN, 53Reactome, 49PharmGKB, 59Tocris Bioscience, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Chronic Myelomonocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1pixy3214410.6FLT3, CSF1, CSF2
2molgramostim4410.6CSF1, CSF2
3idarubicin44 49 1112.6TOP1, FLT3, CSF2
4aclarubicin4410.6TOP1, CSF1
5bcnu4410.6TOP1, CSF1, CSF2
6budesonide44 49 1112.5CSF2, CSF1, MPO
7fluticasone propionate44 49 59 1113.5MPO, CSF1, CSF2
8pkc 4124410.5FLT3, PDGFRB
9ifosfamide44 1111.5CSF2, CSF1, TOP1
10methylcellulose4410.5CSF2, CSF1, GATA2, FLT3
11gp 1304410.5PDGFRB, CSF2, CSF1, FLT3
12n-formylmethionyl-leucylphenylalanine4410.5CSF2, CSF1, MPO
13carboplatin44 49 1112.5MPO, TOP1, CSF1, CSF2
14imatinib44 49 1112.5ETV6, FLT3, CSF1, PDGFRB
15anti-fungal4410.5CSF2, CSF1, DEFA3, DEFA1
16hydroxyurea44 49 1112.5CSF2, CSF1, GATA2, TOP1
17mitoxantrone44 49 1112.4MPO, TOP1, FLT3, CSF1, CSF2
18daunorubicin44 49 1112.4CSF2, CSF1, FLT3, TOP1, MPO
19cyclophosphamide44 49 1112.4MPO, TOP1, CSF1, CSF2
20ag-12964410.4PDGFRB, FLT3
21cytarabine44 49 1112.4CSF2, CSF1, FLT3, TOP1, MPO
22butyrate4410.4GATA2, CSF1, CSF2
235fluorouracil4410.4PDGFRB, CSF2, CSF1, TOP1, MPO
24hbd24410.4DEFA3, DEFA1
25agar4410.4PDGFRB, CSF2, CSF1, TOP1, NRAS, ETV6
26su54164410.4FLT3, PDGFRB
27etoposide44 49 59 1113.4CSF2, CSF1, FLT3, TOP1
28leukotriene b444 59 2412.4MPO, CSF1, CSF2
29cisplatin44 49 59 1113.3MPO, TOP1, CSF1, CSF2, PDGFRB
30h2o24410.3PDGFRB, CSF2, CSF1, TOP1, MPO
31prednisolone44 28 1112.2ETV6, MPO, CSF1
32vegf4410.2PDGFRB, CSF2, CSF1, FLT3, MPO, ETV6
33retinoic acid44 2411.2PDGFRB, CSF2, CSF1, GATA2, FLT3, MPO
34doxorubicin44 49 1112.1CSF2, CSF1, FLT3, TOP1
35tyrosine4410.0PDGFRB, CSF2, CSF1, FLT3, NRAS, HIP1
36capecitabine44 49 1112.0TOP1, PDGFRB
37oligonucleotide4410.0PDGFRB, GATA2, FLT3, NRAS, DNMT3A

GO Terms for genes affiliated with Chronic Myelomonocytic Leukemia

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16Gene Ontology
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Biological processes related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAP kinase activityGO:04340610.3EZH2, FLT3, PDGFRB
2definitive hemopoiesisGO:06021610.3HOXA9, GATA2
3dendritic cell differentiationGO:09702810.2FLT3, CSF2
4positive regulation of cell proliferationGO:00828410.1PDGFRB, CSF2, CSF1, FLT3, NRAS
5positive regulation of macrophage derived foam cell differentiationGO:01074410.0CSF1, CSF2

Molecular functions related to Chronic Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036829.7EZH2, DNMT3A, MPO, TOP1, GATA2
2protein bindingGO:0055159.3HIP1, TOP1, FLT3, GATA2, CSF2, DNMT3A

Products for genes affiliated with Chronic Myelomonocytic Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Myelomonocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet