Chronic Myeloproliferative Disease malady

NIH Rare Diseases: Chronic myeloproliferative disorders are a group of slow-growing blood cancers in which the bone marrow makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in the blood. The type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. Sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others are. There are 6 types of chronic myeloproliferative disorders: chronic myelogenous leukemia (CML), polycythemia vera, primary myelofibrosis (also called chronic idiopathic myelofibrosis), essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. Chronic myeloproliferative disorders sometimes become acute leukemia, in which too many abnormal white blood cells are made.³⁰

MalaCards: Chronic Myeloproliferative Disease, also known as chronic myeloproliferative disorders, is related to thrombosis and myelofibrosis. An important gene associated with Chronic Myeloproliferative Disease is MPL (myeloproliferative leukemia virus oncogene), and among its related pathways are Jak/Stat Pathway and Immune response Oncostatin M signaling via JAK-Stat in human cells. The compounds glucose and cysteine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and endothelial, and related mouse phenotypes are respiratory system and integument.

Disease Ontology: A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.⁶

Aliases & Descriptions:

chronic myeloproliferative disease 6 32 chronic myeloproliferative disorders 30 chronic myeloproliferative disorder 43

campomelic dysplasia 43 cmpd, u 6 cmpd 6

Diseases related to chronic myeloproliferative disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 585)

id	Related Disease	Score	Top Affiliating Genes
1	thrombosis	32.0	MTHFR, F5, F2
2	myelofibrosis	31.7	JAK2, CD177, THPO
3	venous thrombosis	30.4	MTHFR, JAK2, F5, F2
4	essential thrombocythemia	30.4	MPL, JAK2, THPO
5	myelodysplastic syndrome	29.0	MPL, MPO, JAK2, CD177, FLT3, ETV6
6	thromboembolism	29.0	MTHFR, F7, F5, F2
7	urolithiasis	28.2	IL1B, IL6, F2
8	chronic myeloid leukemia	27.3	MPL, MPO, JAK2, CD177, FLT3, ETV6
9	hyperhomocysteinemia	27.1	MTHFR, IL1B, IL6, F7, F5, F2
10	myeloproliferative disorder	26.1	MPL, MPO, JAK2, CD177, FLT3, ETV6
11	polycythemia vera	24.8	MPL, MPO, JAK2, CD177, FLT3, IL6
12	polycythemia	24.7	VEGFA, BCAM, MPL, MPO, JAK2, CD177
13	hematopoiesis	24.0	VEGFA, MPL, JAK2, FLT3, IL1B, IL2
14	cerebritis	24.0	VEGFA, MTHFR, B2M, MPO, JAK2, IL1B
15	myeloid leukemia	20.7	VEGFA, MTHFR, B2M, MPL, MPO, JAK2
16	leukemia	20.4	VEGFA, LDHA, LDHC, MTHFR, B2M, MPL
17	lactate dehydrogenase deficiency	13.7	LDHA, LDHB
18	congenital amegakaryocytic thrombocytopenia	13.6	MPL, THPO
19	hemorrhagic thrombocythemia	13.5	MPL, JAK2, CD177, THPO
20	lactate dehydrogenase-b deficiency	13.5	LDHA, LDHB, LDHC
21	eosinophilic myeloproliferative disorder	13.5	PDGFRA, PDGFRB
22	thrombocytopenia due to platelet alloimmunization	13.5	MPL, THPO
23	autoimmune thrombocytopenic purpura	13.4	MPL, IL2RA, THPO
24	aplastic anemia	13.4	MPL, FLT3, THPO, TFRC
25	hemochromatosis	13.4	B2M, HFE, TFRC
26	stroke, ischemic	13.4	F5, F2
27	crohn's disease	13.3	MPO, STAT3
28	uterine sarcoma	13.3	PDGFRA, PDGFRB, ABL1
29	gliosarcoma	13.3	PDGFRA, PDGFRB, TFRC
30	myeloid malignancy	13.3	MPL, JAK2, FLT3, ETV6
31	prothrombin deficiency	13.3	F5, F2
32	dermatofibrosarcoma protuberans	13.2	PDGFRA, PDGFRB, ABL1
33	hepatic coma	13.2	B2M, F2
34	iron deficiency anemia	13.2	HFE, THPO, TFRC
35	factor x deficiency	13.2	F7, F5, F2
36	factor v deficiency	13.2	F7, F5, F2
37	lymphosarcoma	13.2	LDHA, IL2RA, ABL1
38	juvenile myelomonocytic leukemia	13.2	JAK2, FLT3, PDGFRA, PDGFRB, STAT5A
39	factor xi deficiency	13.2	F7, F5, F2
40	von willebrand's disease	13.2	F7, F5, F2
41	factor viii deficiency	13.2	F7, F5, F2
42	factor vii deficiency	13.2	F7, F5, F2
43	hepatic fibrosis renal cysts mental retardation	13.2	F2, PDGFRB, HFE, THPO
44	dermatofibrosarcoma	13.1	PDGFRA, PDGFRB, ABL1
45	pancytopenia	13.1	MPL, IL2RA, THPO
46	iron metabolism disease	13.1	HFE, TFRC
47	hepatic vein thrombosis	13.1	MTHFR, JAK2, F5
48	macular retinal edema	13.1	VEGFA, CXCL12
49	acute biphenotypic leukemia	13.1	MPO, F2, ABL1
50	hereditary spherocytosis	13.1	F5, HFE, TFRC

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to chronic myeloproliferative disease:

²²

MGI Mouse Phenotypes related to chronic myeloproliferative disease:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	LDHA, STAT5B
2	integument phenotype	MP:0010771	9.3	STAT5A, PDGFRA, ETV6, F2, F5
3	endocrine/exocrine gland phenotype	MP:0005379	9.3	ETV6, IL2, LDHC
4	embryogenesis phenotype	MP:0005380	9.2	ABL1, PDGFRA, ETV6, F2, MPL
5	hematopoietic system phenotype	MP:0005397	9.2	TFRC, THPO, ABL1, PDGFRA, ETV6, FLT3
6	no phenotypic analysis	MP:0003012	8.8	VEGFA, LDHC, MTHFR, F7, ETV6
7	liver/biliary system phenotype	MP:0005370	8.3	STAT5A, ABL1, IL6, IL2, VEGFA
8	skeleton phenotype	MP:0005390	8.1	STAT3, ABL1, IL6, JAK2, MTHFR, VEGFA
9	digestive/alimentary phenotype	MP:0005381	8.0	TFRC, HFE, ABL1, PDGFRB, PDGFRA, ETV6
10	reproductive system phenotype	MP:0005389	7.9	PDGFRA, STAT3, STAT5A, STAT5B, ETV6, IL6
11	tumorigenesis	MP:0002006	7.2	STAT5B, STAT5A, STAT3, PDGFRA, ETV6, IL6
12	normal phenotype	MP:0002873	7.1	PDGFRB, ABL1, HFE, STAT3, STAT5A, STAT5B
13	immune system phenotype	MP:0005387	6.6	HFE, ABL1, PDGFRB, PDGFRA, ETV6, F2
14	nervous system phenotype	MP:0003631	6.0	CXCL12, STAT3, TFRC, ABL1, PDGFRB, PDGFRA
15	growth/size phenotype	MP:0005378	5.7	PDGFRA, PDGFRB, ABL1, HFE, TFRC, STAT3
16	homeostasis/metabolism phenotype	MP:0005376	5.7	ETV6, PDGFRA, PDGFRB, ABL1, HFE, TFRC
17	cellular phenotype	MP:0005384	5.3	PDGFRA, PDGFRB, ABL1, TFRC, STAT3, STAT5A
18	mortality/aging	MP:0010768	5.0	IL6, IL2RA, IL1B, FLT3, JAK2, MPL
19	cardiovascular system phenotype	MP:0005385	4.8	F2, ETV6, PDGFRA, PDGFRB, ABL1, TFRC

Articles related to chronic myeloproliferative disease:

(show all 19)

id	Title	Authors	Year	Affiliating Genes
1	HFE C282Y mutation as a genetic modifier influencing disease susceptibility for chronic myeloproliferative disease. (19258483)	Andrikovics H.... Tordai A.	2009	JAK2, TFRC, HFE
2	Expression of adhesion factor CD239 in bone marrow ce lls in chronic myeloproliferative diseases. (18972067)	Hussein K.... Bock O.	2009	BCAM
3	Mutations in the JAK2 and MPL genes and their correlation to clinical parameters in patients with chronic myeloproliferative disease. (19372714)	Bojko P.... Haferlach T.	2009	JAK2, MPL
4	Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation. (19196872)	Hussein K.... Kreipe H.	2009	JAK2, MPL
5	Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate. (18421200)	Iyama S.... Niitsu Y.	2008	PDGFRB
6	Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation. (17972958)	Hussein K.... Kreipe H.	2008	JAK2, ABL1
7	Serum levels, and bone marrow immunohistochemical expression of, vascular endothelial growth factor in patients with chronic myeloproliferative diseases. (17852434)	Panteli K.... Bourantas K.	2007	VEGFA
8	Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis. (17707884)	Konoplev S.... Lin P.	2007	JAK2
9	Diagnostic algorithm in chronic myeloproliferative diseases (CMPD) (17879017)	Haferlach T.... Haferlach C.	2007	PDGFRA
10	Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation. (17376889)	Teofili L.... Larocca L.M.	2007	JAK2, STAT3, STAT5B
11	Hyperhomocysteinemia--one of the factors underlying thrombotic complications in patients with chronic myeloproliferative diseases (18220034)	Sokolova M.A.... Kulikov S.M.	2007	F2, F7, F5
12	Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases. (16445842)	Vannucchi A.M.... Bosi A.	2006	CD177
13	Recent advances in the bcr-abl negative chronic myeloproliferative diseases. (17032464)	Bennett M.... Stroncek D.F.	2006	MPL
14	Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? (17178662)	Mazzotta S.... Lauria F.	2006	LDHA, LDHB, LDHC
15	SDF1-3'A gene polymorphism is associated with chronic myeloproliferative disease and thrombotic events. (16306115)	Gerli G.... Biondi M.L.	2005	CXCL12
16	Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases. (16115126)	Panteli K.E.... Bourantas K.L.	2005	IL2RA, IL6, IL2
17	Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet- derived growth factor receptor beta. (12181402)	Apperley J.F.... Goldman J.M.	2002	PDGFRB, ABL1, ETV6
18	The role of morphology, cytochemistry and immunohistochemistry in the diagnosis of chronic myeloproliferative diseases. (12430892)	Li C.Y.	2002	MPO
19	Angiogenesis in chronic myeloproliferative diseases. (11815715)	Di Raimondo F.... Giustolisi R.	2001	IL6

Genes related to chronic myeloproliferative disease according to GeneCards:

(show all 30)

id	Symbol	Description	Score	GeneCards Section Context
1	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
2	THPO	thrombopoietin	11.0	Publications
3	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
4	JAK2	Janus kinase 2	11.0	Publications
5	B2M	beta-2-microglobulin	11.0
6	FLT3	fms-related tyrosine kinase 3	11.0
7	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	11.0	Publications
8	CD177	CD177 molecule	11.0	Publications
9	BCAM	basal cell adhesion molecule (Lutheran blood group)	11.0	Publications
10	LDHB	lactate dehydrogenase B	11.0	Publications
11	LDHC	lactate dehydrogenase C	11.0	Publications
12	LDHA	lactate dehydrogenase A	11.0	Publications
13	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
14	STAT5B	signal transducer and activator of transcription 5B	11.0	Publications
15	STAT5A	signal transducer and activator of transcription 5A	11.0	Publications
16	TFRC	transferrin receptor (p90, CD71)	11.0	Publications
17	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
18	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	11.0	Publications
19	HFE	hemochromatosis	11.0	Publications
20	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
21	ETV6	ets variant 6	11.0	Publications
22	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
23	F2	coagulation factor II (thrombin)	11.0	Publications
24	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
25	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
26	MPO	myeloperoxidase	11.0	Publications
27	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
28	VEGFA	vascular endothelial growth factor A	11.0	Publications
29	IL2	interleukin 2	11.0	Publications
30	IL1B	interleukin 1, beta	11.0	Publications

Pathways related to chronic myeloproliferative disease according to GeneDecks:

(show top 50)    (show all 125)

id	Pathway	Score	Top Affiliating Genes
1	Jak/Stat Pathway3	10.5	JAK2, STAT5A
2	Immune response Oncostatin M signaling via JAK-Stat in human cells10	10.1	STAT5B, JAK2, STAT3, STAT5A
3	Development_Thrombopoetin signaling via JAK-STAT pathway41	10.1	STAT5A, MPL, JAK2, THPO, STAT5B
4	Development Thrombopoetin signaling via JAK-STAT pathway10	10.1	MPL, JAK2, STAT3, STAT5A, STAT5B
5	Thrombopoietin Pathway36	9.9	STAT3, STAT5B, STAT5A, JAK2, MPL
6	Immune response_IL-12 signaling pathway41	9.9	STAT5A, STAT5B, JAK2, IL2RA
7	Development PDGF signaling via STATs and NF-kB10	9.8	JAK2, STAT3, PDGFRA, PDGFRB, STAT5A, STAT5B
8	Development_PDGF signaling via STATs and NF-kB41	9.8	JAK2, PDGFRA, PDGFRB, STAT3, STAT5A, STAT5B
9	Immune response IL-12 signaling pathway10	9.8	STAT5A, IL2RA, JAK2, STAT3, STAT5B
10	PDGF Pathway36	9.7	JAK2, PDGFRA, STAT5B, STAT5A, STAT3, PDGFRB
11	Immune response_Oncostatin M signaling via JAK-Stat in human cells41	9.5	STAT3, STAT5B, JAK2, STAT5A, VEGFA
12	Tyrosine Kinases / Adaptors3	9.3	PDGFRB, JAK2, ABL1, PDGFRA, IL2RA, FLT3
13	Actin-Based Motility by Rho Family GTPases36	9.2	THPO, IL2
14	Pathways in cancer20	9.2	VEGFA, STAT3, FLT3, STAT5A, PDGFRA, ABL1
15	Th1 Differentiation37	9.2	IL2, STAT5A, JAK2, STAT3, STAT5B
16	Th17 Differentiation37	9.1	STAT5B, STAT5A, STAT3, IL6, IL1B, JAK2
17	Telomerase Components in Cell Signaling36	9.0	CXCL12, THPO, ABL1, PDGFRA, PDGFRB, IL2
18	Immune response IL-22 signaling pathway10	8.9	JAK2, IL2, IL2RA, STAT3, STAT5B, STAT5A
19	Immune response_IL-22 signaling pathway41	8.9	STAT5A, STAT3, IL2RA, IL2, JAK2, STAT5B
20	Hematopoietic cell lineage20	8.9	IL6, THPO, IL2RA, FLT3, IL1B, TFRC
21	Molecular Mechanisms of Cancer36	8.7	CXCL12, ABL1, PDGFRA, IL6, IL2
22	Jak-STAT signaling pathway20	8.3	MPL, STAT5A, STAT5B, JAK2, IL2RA, STAT3
23	Nanog in Mammalian ESC Pluripotency36	8.3	IL2, THPO, PDGFRB, PDGFRA, IL6, CXCL12
24	Apoptotic Pathways in Synovial Fibroblasts36	8.3	IL2, IL2RA, IL6, PDGFRA, PDGFRB, THPO
25	p53 Mediated Apoptosis36	8.3	IL6, IL2, CXCL12, THPO, IL2RA, PDGFRA
26	Mitochondrial Apoptosis36	8.2	IL6, THPO, CXCL12, PDGFRA, IL2RA, IL2
27	ERK5 Signaling36	8.2	CXCL12, THPO, IL2RA, PDGFRA, IL6, PDGFRB
28	Cellular Apoptosis Pathway36	8.2	CXCL12, THPO, PDGFRA, IL6, IL2RA, PDGFRB
29	PPAR Pathway36	8.1	IL2RA, IL6, PDGFRA, PDGFRB, THPO, IL2
30	Endothelin-1 Signaling Pathway36	8.1	FLT3, IL2, IL6, IL1B, PDGFRB, PDGFRA
31	eIF2 Pathway36	8.1	IL6, PDGFRA, PDGFRB, THPO, CXCL12, IL2RA
32	Akt Signaling36	8.0	THPO, PDGFRA, FLT3, IL2, IL2RA, IL6
33	Renin-Angiotensin Pathway36	8.0	IL6, PDGFRA, IL2RA, IL2, JAK2, PDGFRB
34	Nuclear Receptor Activation by Vitamin-A36	8.0	PDGFRA, IL6, IL2RA, IL2, PDGFRB, THPO
35	JNK Pathway36	8.0	IL6, IL2, IL2RA, PDGFRA, FLT3, THPO
36	GPCR Pathway36	8.0	IL2, IL6, PDGFRA, PDGFRB, STAT5A, STAT3
37	Measles20	7.9	STAT5A, IL1B, STAT5B, STAT3, IL2RA, IL2
38	Activation of PKC through GPCR36	7.9	THPO, PDGFRB, PDGFRA, IL6, IL2RA, IL2
39	p70S6K Signaling36	7.9	IL6, THPO, F2, PDGFRA, PDGFRB, CXCL12
40	Pancreatic Adenocarcinoma36	7.8	IL6, PDGFRA, IL2, THPO, STAT3, STAT5A
41	Rac1 Pathway36	7.8	IL2, IL2RA, IL6, PDGFRA, PDGFRB, THPO
42	DHA Signaling36	7.8	IL2RA, IL2, PDGFRA, IL6, PDGFRB, THPO
43	PAK Pathway36	7.7	THPO, PDGFRB, PDGFRA, IL6, IL2RA, IL2
44	STAT3 Pathway36	7.6	JAK2, IL2, IL1B, IL2RA, IL6, STAT3
45	Antioxidant Action of Vitamin-C36	7.6	IL2, IL2RA, IL6, PDGFRA, PDGFRB, THPO
46	p38 Signaling36	7.6	THPO, PDGFRB, IL2, CXCL12, PDGFRA, FLT3
47	Tec Kinases Signaling36	7.1	IL2, JAK2, IL1B, IL2RA, CXCL12, STAT5A
48	MAPK Signaling36	7.1	CXCL12, STAT5A, STAT3, THPO, PDGFRB, PDGFRA
49	Cytokine-cytokine receptor interaction20	7.1	PDGFRB, CXCL12, PDGFRA, IL6, IL2RA, IL1B
50	JAK-STAT Pathway36	6.5	IL2, IL2RA, IL1B, FLT3, CXCL12, JAK2

Compounds related to chronic myeloproliferative disease according to GeneDecks:

(show top 50)    (show all 171)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.2	THPO, LDHB, LDHA
2	cysteine32	9.9	MPL, PDGFRB, MTHFR, TFRC
3	agar32	9.8	JAK2, ABL1, THPO, ETV6, PDGFRB
4	n acetylcysteine32	9.8	JAK2, STAT3, IL2RA, F2
5	polyethylene glycol32	9.8	MPL, MPO, TFRC
6	dasatinib32 34 9 9	12.8	STAT5A, STAT5B, PDGFRB, ABL1, STAT3
7	hyaluronic acid32 18	10.8	THPO, B2M, F2, CXCL12
8	pkc 41232	9.7	FLT3, PDGFRA, PDGFRB, STAT5A
9	ag-129632	9.7	FLT3, STAT5A, PDGFRB, PDGFRA
10	su541632	9.5	STAT5A, STAT3, PDGFRB, FLT3, VEGFA
11	gp 13032	9.5	STAT5B, STAT5A, THPO, IL2RA, FLT3, JAK2
12	estrogen32	9.5	HFE, PDGFRB, PDGFRA, F2, MTHFR
13	vitamin-e32	9.2	JAK2, B2M, STAT3, F5, F7, IL2RA
14	phosphotyrosine32	9.2	PDGFRA, JAK2, PDGFRB, ABL1, STAT3, STAT5A
15	rituximab32 34 9 9	12.1	STAT3, CXCL12, IL2RA, IL2
16	aspartate32	9.0	STAT5A, STAT3, HFE, ABL1, F2, B2M
17	calcitriol32 42 9 18 9	12.9	PDGFRA, IL2RA, IL2, TFRC, B2M, PDGFRB
18	pge132	8.8	F5, CXCL12, TFRC, F2, B2M, IL6
19	sunitinib32 9 9	10.8	PDGFRB, FLT3, PDGFRA, IL2, VEGFA
20	sb 20358032 42	9.7	VEGFA, THPO, STAT3, IL6, CXCL12, STAT5A
21	ly29400232	8.6	IL6, STAT5A, STAT3, VEGFA, IL1B, STAT5B
22	ifn-alpha32	8.4	CXCL12, STAT3, STAT5A, IL2, IL6, IL2RA
23	rapamycin32 42	9.4	STAT5A, STAT5B, VEGFA, JAK2, IL2, PDGFRA
24	aspirin32 34 18	10.4	F2, F5, THPO, IL2RA, MTHFR, JAK2
25	taurine chloramine32	8.3	F5, IL6, IL2, IL1B, MPO
26	bucillamine32	8.2	IL6, IL2, VEGFA, IL1B
27	phosphatidylinositol32	8.2	CXCL12, PDGFRA, PDGFRB, MPL, STAT5B, STAT5A
28	neopterin32	8.1	B2M, IL1B, IL2, TFRC, IL6, IL2RA
29	lactate32	8.0	MPO, LDHB, LDHC, B2M, FLT3, IL6
30	gm-csf32	8.0	THPO, STAT5A, IL2, IL1B, VEGFA, IL6
31	thalidomide32 42 9 9	11.0	B2M, IL1B, IL2, IL6, STAT3, VEGFA
32	imatinib32 34 9 9	11.0	PDGFRA, PDGFRB, ABL1, THPO, STAT3, STAT5A
33	testosterone32 9 18 9	10.9	LDHC, TFRC, MTHFR, STAT3, B2M, IL2RA
34	cholesterol32 9 18 9	10.8	F5, JAK2, PDGFRB, HFE, STAT3, CXCL12
35	vegf32	7.6	ABL1, PDGFRB, PDGFRA, JAK2, CXCL12, THPO
36	creatinine32	7.6	IL2RA, F5, F7, IL6, MPO, TFRC
37	alanine32	7.5	STAT5B, MTHFR, B2M, MPL, JAK2, IL6
38	cyclosporin a32 42	8.5	F2, MTHFR, JAK2, B2M, IL2, IL2RA
39	herbimycin a32 42	8.3	IL6, JAK2, FLT3, IL1B, IL2, IL2RA
40	5fluorouracil32	7.3	PDGFRB, IL2, STAT3, MPL, IL2RA, MPO
41	actinomycin d32	7.3	STAT3, JAK2, VEGFA, CXCL12, TFRC, THPO
42	indomethacin32 9 9	9.3	IL6, THPO, TFRC, STAT5A, IL2RA, IL2
43	cisplatin32 34 9 9	10.1	STAT3, IL2RA, VEGFA, IL2, JAK2, MPO
44	cycloheximide32	6.9	IL6, VEGFA, STAT5B, STAT5A, STAT3, TFRC
45	dexamethasone32 42 34 9 9	10.7	IL1B, IL2, IL2RA, IL6, THPO, STAT3
46	genistein32 9 18 9	9.5	VEGFA, THPO, PDGFRB, IL6, JAK2, STAT3
47	thymidine32 18	7.5	B2M, MTHFR, FLT3, JAK2, IL1B, IL2
48	serine32	6.4	MPL, F7, CXCL12, B2M, MTHFR, STAT3
49	retinoic acid32 42 18	8.4	B2M, MTHFR, STAT5B, ETV6, STAT3, STAT5A
50	tyrosine32	5.3	STAT5A, STAT5B, CXCL12, STAT3, TFRC, VEGFA

Cellular components related to chronic myeloproliferative disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic to plasma membrane	GO:031226	10.1	PDGFRA, PDGFRB
2	extracellular region	GO:005576	6.2	F5, F2, TFRC, CXCL12, F7, IL6
3	extracellular space	GO:005615	6.0	VEGFA, CXCL12, THPO, F2, F5, F7

Biological processes related to chronic myeloproliferative disease according to GeneDecks:

(show all 36)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of steroid metabolic process	GO:019218	10.4	STAT5A, STAT5B
2	development of secondary female sexual characteristics	GO:046543	10.3	STAT5A, STAT5B
3	metanephric glomerular capillary formation	GO:072277	10.3	PDGFRB, PDGFRA
4	platelet-derived growth factor receptor signaling pathway	GO:048008	10.3	JAK2, PDGFRA, PDGFRB
5	cellular carbohydrate metabolic process	GO:044262	10.3	LDHA, LDHB, LDHC
6	development of secondary male sexual characteristics	GO:046544	10.3	STAT5B, STAT5A
7	isoleucine metabolic process	GO:006549	10.2	STAT5B, STAT5A
8	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.2	PDGFRB, PDGFRA, FLT3
9	allantoin metabolic process	GO:000255	10.2	STAT5B, STAT5A
10	T cell differentiation in thymus	GO:033077	10.2	STAT5B, STAT5A, B2M
11	creatinine metabolic process	GO:046449	10.2	STAT5B, STAT5A
12	luteinization	GO:001553	10.2	STAT5B, STAT5A, PDGFRA
13	regulation of multicellular organism growth	GO:040014	10.2	STAT3, STAT5A, STAT5B
14	taurine metabolic process	GO:019530	10.2	STAT5B, STAT5A
15	blood circulation	GO:008015	10.2	CXCL12
16	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.1	STAT5B, STAT5A, STAT3, JAK2
17	JAK-STAT cascade	GO:007259	10.1	JAK2, STAT3, STAT5A, STAT5B
18	positive regulation of interleukin-2 biosynthetic process	GO:045086	9.9	IL1B, STAT5A, STAT5B
19	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	9.9	VEGFA, PDGFRA, PDGFRB
20	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.9	PDGFRB, PDGFRA, F2, FLT3, JAK2
21	vascular endothelial growth factor receptor signaling pathway	GO:048010	9.8	PDGFRB, PDGFRA, VEGFA
22	regulation of cell adhesion	GO:030155	9.8	STAT5B, STAT5A, ABL1
23	peptidyl-tyrosine phosphorylation	GO:018108	9.7	JAK2, STAT5A, ABL1, PDGFRB, PDGFRA, FLT3
24	positive regulation of MAP kinase activity	GO:043406	9.6	VEGFA, FLT3, PDGFRB
25	glycolysis	GO:006096	9.6	LDHA, LDHB, LDHC
26	acute-phase response	GO:006953	9.6	IL6, F2, STAT3, STAT5B
27	positive regulation of activated T cell proliferation	GO:042104	9.6	STAT5B, STAT5A, IL2
28	positive regulation of smooth muscle cell proliferation	GO:048661	9.5	IL6, PDGFRB, STAT5B
29	positive regulation of cell migration	GO:030335	9.5	PDGFRB, PDGFRA, F7, JAK2, VEGFA
30	positive regulation of inflammatory response	GO:050729	9.4	STAT5B, STAT5A, IL2, JAK2
31	elevation of cytosolic calcium ion concentration	GO:007204	9.0	PDGFRA, IL2, IL1B, JAK2
32	platelet activation	GO:030168	8.8	THPO, F2, F5, IL6, MPL, VEGFA
33	cytokine-mediated signaling pathway	GO:019221	8.8	STAT5B, STAT5A, STAT3, IL6, IL1B, FLT3
34	blood coagulation	GO:007596	8.6	THPO, ABL1, F2, F5, F7, CD177
35	positive regulation of cell proliferation	GO:008284	7.8	THPO, PDGFRB, PDGFRA, F2, IL6, IL2
36	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.7	STAT5B, STAT5A, STAT3, IL6, IL2, IL1B

Molecular functions related to chronic myeloproliferative disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor binding	GO:038085	10.1	PDGFRA, PDGFRB
2	L-lactate dehydrogenase activity	GO:004459	10.0	LDHA, LDHB, LDHC
3	vascular endothelial growth factor-activated receptor activity	GO:005021	9.9	PDGFRB, PDGFRA, FLT3
4	platelet-derived growth factor receptor binding	GO:005161	9.4	VEGFA, PDGFRA, PDGFRB
5	cytokine activity	GO:005125	7.6	THPO, IL6, IL2, IL1B, VEGFA
6	growth factor activity	GO:008083	7.3	VEGFA, CXCL12, THPO, F2, IL6, IL2