MCID: CHR092
MIFTS: 43

Chronic Myeloproliferative Disease malady

Rare diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Chronic Myeloproliferative Disease

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Chronic Myeloproliferative Disease, Aliases & Descriptions:

Name: Chronic Myeloproliferative Disease 9 11 43
Chronic Myeloproliferative Disorders 41
Chronic Myeloproliferative Disorder 60
 
Campomelic Dysplasia 60
Cmpd, U 9
Cmpd 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:2226
NCIt38 C4345
ICD1025 D47.1

Summaries for Chronic Myeloproliferative Disease

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NIH Rare Diseases:41 Chronic myeloproliferative disorders are a group of slow-growing blood cancers in which the bone marrow makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in the blood. the type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others are.there are 6 types of chronic myeloproliferative disorders: chronic myelogenous leukemia (cml), polycythemia vera, primary myelofibrosis (also called chronic idiopathic myelofibrosis), essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. chronic myeloproliferative disorders sometimes become acute leukemia, in which too many abnormal white blood cells are made. last updated: 3/31/2011

MalaCards based summary: Chronic Myeloproliferative Disease, also known as chronic myeloproliferative disorders, is related to essential thrombocythemia and polycythemia. An important gene associated with Chronic Myeloproliferative Disease is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Integrin alphaIIb beta3 signaling and Immune response IL 23 signaling pathway. The compounds megapoietin and ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and neutrophil, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:9 A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

Related Diseases for Chronic Myeloproliferative Disease

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Diseases in the 8p11 Myeloproliferative Syndrome family:

chronic myeloproliferative disease Transient Myeloproliferative Syndrome

Diseases related to Chronic Myeloproliferative Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1essential thrombocythemia30.3THPO, MPL, JAK2
2polycythemia30.3THPO, MPL, JAK2
3myelofibrosis30.3THPO, JAK2
4eosinophilia30.3PDGFRB, JAK2
5bone marrow cancer30.2PDGFRB, JAK2, MPL
6acute leukemia29.6JAK2, FLT3, MPL, THPO
7myeloid leukemia29.6JAK2, FLT3, MPL, THPO
8thrombocytosis29.5THPO, MPL, FLT3, JAK2
9polycythemia vera29.3THPO, MPL, FLT3, JAK2, PDGFRB
10myelodysplastic syndrome29.3THPO, MPL, FLT3, JAK2, PDGFRB
11leukemia29.1THPO, B2M, MPL, FLT3, JAK2, PDGFRB
12thrombocythemia 110.4THPO
13unclassified chronic myeloproliferative disease10.4
14pdgfrb-associated chronic eosinophilic leukemia10.4
15purpura10.4THPO
16synovitis10.3B2M
17cerebritis10.3
18thrombocytopenia, congenital amegakaryocytic10.2MPL, THPO
19thrombocytopenia due to platelet alloimmunization10.2MPL, THPO
20thrombocytopenic purpura, autoimmune10.2MPL, THPO
21pancytopenia10.2MPL, THPO
22systemic mastocytosis10.2PDGFRB, JAK2
23erythromelalgia10.1
24portal vein thrombosis10.1
25paraplegia10.1
26tetrasomy 2110.1
27hepatoblastoma10.1THPO, MPL
28severe congenital neutropenia10.1THPO, JAK2
29dilated cardiomyopathy10.1
30hyperhomocysteinemia10.1
31cryptococcosis10.1
32lymphoblastic leukemia10.1
33endotheliitis10.1
34neutropenia10.1THPO, MPL
35campomelic dysplasia10.1
36gastrointestinal stromal tumor10.0FLT3, PDGFRB
37thrombocytopenia10.0THPO, MPL
38splenomegaly9.9THPO, MPL, JAK2
39chromosomal triplication9.9FLT3, JAK2
40acute erythroid leukemia9.9THPO, MPL, JAK2
41factor v leiden thrombophilia9.9THPO, MPL, JAK2
42sarcoma9.9PDGFRB, JAK2, THPO
43liver cirrhosis9.9MPL, THPO
44aplastic anemia9.8THPO, MPL, FLT3
45precursor t-cell acute lymphoblastic leukemia9.8JAK2, FLT3
46hodgkin lymphoma9.8JAK2, FLT3
47kidney cancer9.8B2M, FLT3, PDGFRB
48rheumatoid arthritis9.8JAK2, B2M, THPO
49lymphoma, non-hodgkin9.7JAK2, FLT3, B2M
50chronic myelomonocytic leukemia9.6MPL, FLT3, JAK2, PDGFRB

Graphical network of the top 20 diseases related to Chronic Myeloproliferative Disease:



Diseases related to chronic myeloproliferative disease

Symptoms for Chronic Myeloproliferative Disease

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Drugs & Therapeutics for Chronic Myeloproliferative Disease

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Drug clinical trials:

Search ClinicalTrials for Chronic Myeloproliferative Disease

Search NIH Clinical Center for Chronic Myeloproliferative Disease

Genetic Tests for Chronic Myeloproliferative Disease

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Anatomical Context for Chronic Myeloproliferative Disease

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MalaCards organs/tissues related to Chronic Myeloproliferative Disease:

31
Bone, Bone marrow, Neutrophil, Spleen, Myeloid, Endothelial

Animal Models for Chronic Myeloproliferative Disease or affiliated genes

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MGI Mouse Phenotypes related to Chronic Myeloproliferative Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6B2M, MPL, FLT3, JAK2, PDGFRB
2MP:00107687.6PDGFRB, JAK2, FLT3, MPL, B2M
3MP:00053787.5PDGFRB, JAK2, FLT3, MPL, B2M
4MP:00053767.3B2M, MPL, FLT3, JAK2, PDGFRB
5MP:00053977.2PDGFRB, JAK2, FLT3, MPL, B2M, THPO
6MP:00053877.2THPO, B2M, MPL, FLT3, JAK2, PDGFRB

Publications for Chronic Myeloproliferative Disease

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Articles related to Chronic Myeloproliferative Disease:

(show all 38)
idTitleAuthorsYear
1
Reversible dilated cardiomyopathy associated with long-term anagrelide therapy in a patient with chronic myeloproliferative disease: a serial 2-dimensional speckle tracking echocardiographic study. (24698230)
2014
2
Fasting glucose level reduction induced by imatinib in chronic myeloproliferative disease with TEL-PDGFRI^ rearrangement and type 1 diabetes. (22623162)
2012
3
Inferior vena cava thrombosis and its relationship with the JAK2V617F mutation and chronic myeloproliferative disease. (21982959)
2012
4
Plasma levels of JAK2 mRNA in patients with chronic myeloproliferative diseases with and without V617F mutation: implications for prognosis and disease biology. (19254349)
2010
5
Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases. (18972067)
2009
6
Mutations in the JAK2 and MPL genes and their correlation to clinical parameters in patients with chronic myeloproliferative disease. (19372714)
2009
7
Philadelphia chromosome-negative chronic myeloproliferative disease. (19605821)
2009
8
Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation. (19196872)
2009
9
HFE C282Y mutation as a genetic modifier influencing disease susceptibility for chronic myeloproliferative disease. (19258483)
2009
10
Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate. (18421200)
2008
11
Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation. (17972958)
2008
12
A novel ETV6-PDGFRB fusion transcript missed by standard screening in a patient with an imatinib responsive chronic myeloproliferative disease. (17508004)
2007
13
Improvement of fibrosis in a patient with chronic myeloproliferative disease. (17910624)
2007
14
Molecular diagnosis of chronic myeloproliferative diseases and myelodysplastic syndromes]. (18314608)
2007
15
Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation. (17376889)
2007
16
Serum levels, and bone marrow immunohistochemical expression of, vascular endothelial growth factor in patients with chronic myeloproliferative diseases. (17852434)
2007
17
Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis. (17707884)
2007
18
Donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) after cord blood transplantation in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. (17875537)
2007
19
Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation. (17449802)
2007
20
Hyperhomocysteinemia--one of the factors underlying thrombotic complications in patients with chronic myeloproliferative diseases]. (18220034)
2007
21
Diagnostic algorithm in chronic myeloproliferative diseases (CMPD)]. (17879017)
2007
22
Recent advances in the bcr-abl negative chronic myeloproliferative diseases. (17032464)
2006
23
Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? (17178662)
2006
24
Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases. (16445842)
2006
25
SDF1-3'A gene polymorphism is associated with chronic myeloproliferative disease and thrombotic events. (16306115)
2005
26
Localized cutaneous cryptococcosis in a patient with chronic myeloproliferative disease. (16334871)
2005
27
Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. (15618966)
2005
28
Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases. (16115126)
2005
29
Inv(1)(p22q25) in chronic myeloproliferative disease: constitutional or clonal defect? (15796968)
2005
30
A rapidly progressive chronic myeloproliferative disease with isolated trisomy 6. (15036897)
2004
31
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet- derived growth factor receptor beta. (12181402)
2002
32
The role of morphology, cytochemistry and immunohistochemistry in the diagnosis of chronic myeloproliferative diseases. (12430892)
2002
33
Angiogenesis in chronic myeloproliferative diseases. (11815715)
2001
34
Clonality analysis using X-chromosome inactivation at the human androgen receptor gene (Humara). Evaluation of large cohorts of patients with chronic myeloproliferative diseases, secondary neutrophilia, and reactive thrombocytosis. (10396290)
1999
35
N-RAS activation in the terminal stage of undifferentiated chronic myeloproliferative disease. (1391809)
1992
36
Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells. (1682923)
1991
37
Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease. (2397474)
1990
38
Functional and morphological studies of platelet reactivity with vessel wall subendothelium in chronic myeloproliferative disease. (6944099)
1981

Variations for Chronic Myeloproliferative Disease

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Expression for genes affiliated with Chronic Myeloproliferative Disease

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Search GEO for disease gene expression data for Chronic Myeloproliferative Disease.

Pathways for genes affiliated with Chronic Myeloproliferative Disease

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Pathways related to Chronic Myeloproliferative Disease according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MPL, THPO
2
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.4PDGFRB, JAK2
3
Show member pathways
S1P2 pathway36
S1P4 pathway36
S1P5 pathway36
S1P1 pathway36
Sphingosine 1-phosphate (S1P) pathway36
9.4PDGFRB, JAK2
49.4JAK2, PDGFRB
5
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.3JAK2, B2M
6
Show member pathways
9.2FLT3, PDGFRB
79.1FLT3, THPO
8
Show member pathways
9.0JAK2, FLT3
9
Show member pathways
8.9THPO, JAK2, PDGFRB
10
Show member pathways
8.9THPO, JAK2, PDGFRB
11
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.9THPO, MPL, JAK2
12
Show member pathways
8.9JAK2, MPL, THPO
13
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
8.9JAK2, MPL, THPO
14
Show member pathways
8.7PDGFRB, FLT3, THPO
15
Show member pathways
8.7THPO, FLT3, PDGFRB
16
Show member pathways
8.7THPO, FLT3, PDGFRB
178.6FLT3, JAK2, PDGFRB
18
Show member pathways
8.2PDGFRB, JAK2, FLT3, MPL
19
Show member pathways
8.1THPO, FLT3, JAK2, PDGFRB
20
Show member pathways
8.1PDGFRB, JAK2, FLT3, THPO
21
Show member pathways
8.1PDGFRB, JAK2, FLT3, THPO
22
Show member pathways
7.6PDGFRB, JAK2, FLT3, MPL, THPO

Compounds for genes affiliated with Chronic Myeloproliferative Disease

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Compounds related to Chronic Myeloproliferative Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1megapoietin439.9MPL, THPO
2ifosfamide43 1210.7THPO, B2M
3pkc 412439.6PDGFRB, FLT3
4ag-1296439.6PDGFRB, FLT3
5phorbol 12,13-dibutyrate439.6JAK2, THPO
6ang ii439.6JAK2, PDGFRB
7su5416439.6FLT3, PDGFRB
8sunitinib43 49 1211.6PDGFRB, FLT3
9pixy321439.5THPO, FLT3
105fluorouracil439.5THPO, MPL, PDGFRB
11lestaurtinib43 5910.4JAK2, FLT3
12anagrelide43 1210.3JAK2, MPL, THPO
13sorafenib43 49 1211.3PDGFRB, FLT3
14matrigel439.3PDGFRB, JAK2, THPO
15methylcellulose439.3FLT3, THPO
16aspirin43 49 28 2412.2JAK2, MPL, THPO
17ly294002439.2THPO, JAK2, PDGFRB
18iron43 2410.2MPL, B2M, THPO
19wortmannin439.2THPO, JAK2, PDGFRB
20thromboxane43 2410.2THPO, MPL
21indomethacin43 28 59 1212.1THPO, B2M, JAK2
22butyrate439.1JAK2, B2M, THPO
23tgf beta1439.1PDGFRB, FLT3, THPO
24lysine439.1THPO, MPL, JAK2
25cisplatin43 49 59 1212.0PDGFRB, JAK2, B2M
26phosphotyrosine439.0PDGFRB, JAK2, FLT3
27h2o2438.9PDGFRB, JAK2, THPO
28agar438.9THPO, MPL, JAK2, PDGFRB
295-aza-2deoxycytidine438.9JAK2, FLT3, THPO
30phosphoinositide438.9PDGFRB, JAK2, FLT3
31genistein43 28 59 2 24 1213.8THPO, B2M, JAK2, PDGFRB
32lactate438.8FLT3, B2M, THPO
33estrogen438.8THPO, B2M, JAK2, PDGFRB
34glucose438.7THPO, B2M, JAK2, PDGFRB
35threonine438.6MPL, FLT3, JAK2, PDGFRB
36imatinib43 49 1210.5THPO, FLT3, JAK2, PDGFRB
37rapamycin438.5PDGFRB, JAK2, FLT3, THPO
38aspartate438.5B2M, FLT3, JAK2
39oligonucleotide438.5THPO, FLT3, JAK2, PDGFRB
40atp43 289.5THPO, FLT3, JAK2, PDGFRB
41thymidine43 249.4THPO, B2M, FLT3, JAK2
42alanine438.4THPO, B2M, MPL, JAK2, PDGFRB
43cysteine438.4THPO, B2M, MPL, JAK2, PDGFRB
44serine438.4PDGFRB, JAK2, MPL, B2M
45gp 130438.1PDGFRB, JAK2, FLT3, MPL, THPO
46phosphatidylinositol438.1PDGFRB, JAK2, FLT3, MPL, THPO
47adp43 28 2410.1THPO, MPL, FLT3, JAK2, PDGFRB
48tyrosine438.1THPO, MPL, FLT3, JAK2, PDGFRB
49retinoic acid43 249.0THPO, B2M, FLT3, JAK2, PDGFRB
50vegf437.6THPO, B2M, MPL, FLT3, JAK2, PDGFRB

GO Terms for genes affiliated with Chronic Myeloproliferative Disease

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Biological processes related to Chronic Myeloproliferative Disease according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphoprotein phosphatase activityGO:00325169.7PDGFRB, JAK2
2platelet-derived growth factor receptor signaling pathwayGO:00480089.6JAK2, PDGFRB
3positive regulation of cell migrationGO:00303359.4PDGFRB, JAK2
4positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.4PDGFRB, FLT3
5positive regulation of MAP kinase activityGO:00434069.4PDGFRB, FLT3
6positive regulation of ERK1 and ERK2 cascadeGO:00703749.2PDGFRB, THPO
7interferon-gamma-mediated signaling pathwayGO:00603339.2JAK2, B2M
8positive regulation of phosphatidylinositol 3-kinase signalingGO:00140688.9PDGFRB, JAK2, FLT3
9blood coagulationGO:00075968.9THPO, MPL, JAK2
10peptidyl-tyrosine phosphorylationGO:00181088.9PDGFRB, JAK2, FLT3
11protein autophosphorylationGO:00467778.8FLT3, JAK2, PDGFRB
12cytokine-mediated signaling pathwayGO:00192218.7JAK2, FLT3, B2M
13positive regulation of cell proliferationGO:00082848.7PDGFRB, JAK2, FLT3

Molecular functions related to Chronic Myeloproliferative Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.4PDGFRB, JAK2
2cytokine receptor activityGO:00048968.9FLT3, MPL
3phosphatidylinositol 3-kinase bindingGO:00435488.5PDGFRB, JAK2, FLT3

Products for genes affiliated with Chronic Myeloproliferative Disease

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Sources for Chronic Myeloproliferative Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet