MCID: CHR092
MIFTS: 50

Chronic Myeloproliferative Disease malady

Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Chronic Myeloproliferative Disease

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NIH Rare Diseases:43 Chronic myeloproliferative disorders are a group of slow-growing blood cancers in which the bone marrow makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in the blood. the type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others are.there are 6 types of chronic myeloproliferative disorders: chronic myelogenous leukemia (cml), polycythemia vera, primary myelofibrosis (also called chronic idiopathic myelofibrosis), essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. chronic myeloproliferative disorders sometimes become acute leukemia, in which too many abnormal white blood cells are made. last updated: 3/31/2011

MalaCards based summary: Chronic Myeloproliferative Disease, also known as chronic myeloproliferative disorders, is related to essential thrombocythemia and polycythemia. An important gene associated with Chronic Myeloproliferative Disease is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Integrin alphaIIb beta3 signaling and Signaling events mediated by PTP1B. The compounds megapoietin and ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and neutrophil, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:10 A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

Aliases & Classifications for Chronic Myeloproliferative Disease

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Chronic Myeloproliferative Disease, Aliases & Descriptions:

Name: Chronic Myeloproliferative Disease 10 12 45
Chronic Myeloproliferative Disorders 43 62
Chronic Myeloproliferative Disorder 62
 
Campomelic Dysplasia 62
Cmpd, U 10
Cmpd 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology10 DOID:2226
NCIt40 C4345
ICD1027 D47.1

Related Diseases for Chronic Myeloproliferative Disease

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Diseases in the 8p11 Myeloproliferative Syndrome family:

chronic myeloproliferative disease Transient Myeloproliferative Syndrome

Diseases related to Chronic Myeloproliferative Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1essential thrombocythemia30.4MPL, JAK2, THPO
2polycythemia30.4JAK2, THPO, MPL
3leukemia30.2MPL, B2M, THPO, FLT3, JAK2, PDGFRB
4bone marrow cancer30.2PDGFRB, JAK2, MPL
5myelofibrosis30.2JAK2, THPO
6eosinophilia30.2PDGFRB, JAK2
7acute leukemia30.1THPO, MPL, FLT3, JAK2
8myeloid leukemia30.1MPL, THPO, FLT3, JAK2
9polycythemia vera30.1PDGFRB, JAK2, FLT3, MPL, THPO
10thrombocytosis30.1FLT3, MPL, THPO, JAK2
11myelodysplastic syndrome30.0JAK2, PDGFRB, THPO, MPL, FLT3
12pdgfrb-associated chronic eosinophilic leukemia10.5
13unclassified chronic myeloproliferative disease10.3
14cerebritis10.3
15campomelic dysplasia10.2
16erythromelalgia10.1
17portal vein thrombosis10.1
18paraplegia10.1
19tetrasomy 2110.1
20dilated cardiomyopathy10.1
21hyperhomocysteinemia10.1
22cryptococcosis10.1
23lymphoblastic leukemia10.1
24endotheliitis10.1
25thrombocythemia 110.0THPO
26purpura10.0THPO
27synovitis10.0B2M
28thrombocytopenia, congenital amegakaryocytic10.0THPO, MPL
29thrombocytopenia due to platelet alloimmunization10.0THPO, MPL
30thrombocytopenic purpura, autoimmune10.0MPL, THPO
31systemic mastocytosis10.0PDGFRB, JAK2
32pancytopenia10.0THPO, MPL
33hepatoblastoma10.0THPO, MPL
34severe congenital neutropenia10.0JAK2, THPO
35neutropenia10.0THPO, MPL
36gastrointestinal stromal tumor10.0PDGFRB, FLT3
37thrombocytopenia10.0MPL, THPO
38splenomegaly10.0JAK2, MPL, THPO
39acute erythroid leukemia10.0THPO, MPL, JAK2
40liver cirrhosis10.0THPO, MPL
41factor v leiden thrombophilia10.0MPL, THPO, JAK2
42sarcoma10.0THPO, JAK2, PDGFRB
43aplastic anemia10.0FLT3, MPL, THPO
44precursor t-cell acute lymphoblastic leukemia10.0JAK2, FLT3
45hodgkin lymphoma10.0FLT3, JAK2
46kidney cancer10.0B2M, FLT3, PDGFRB
47rheumatoid arthritis10.0THPO, JAK2, B2M
48lymphoma, non-hodgkin10.0JAK2, B2M, FLT3
49chronic myelomonocytic leukemia9.9PDGFRB, JAK2, MPL, FLT3
50burkitt lymphoma9.9B2M, JAK2, FLT3

Graphical network of the top 20 diseases related to Chronic Myeloproliferative Disease:



Diseases related to chronic myeloproliferative disease

Symptoms for Chronic Myeloproliferative Disease

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Drugs & Therapeutics for Chronic Myeloproliferative Disease

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Drug clinical trials:

Search ClinicalTrials for Chronic Myeloproliferative Disease

Search NIH Clinical Center for Chronic Myeloproliferative Disease

Genetic Tests for Chronic Myeloproliferative Disease

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Anatomical Context for Chronic Myeloproliferative Disease

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MalaCards organs/tissues related to Chronic Myeloproliferative Disease:

33
Bone, Bone marrow, Neutrophil, Spleen, Myeloid, Endothelial

Animal Models for Chronic Myeloproliferative Disease or affiliated genes

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MGI Mouse Phenotypes related to Chronic Myeloproliferative Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6MPL, PDGFRB, JAK2, FLT3, B2M
2MP:00107687.6JAK2, FLT3, MPL, B2M, PDGFRB
3MP:00053787.5FLT3, PDGFRB, B2M, MPL, JAK2
4MP:00053767.3B2M, MPL, FLT3, JAK2, PDGFRB
5MP:00053977.2THPO, PDGFRB, JAK2, FLT3, MPL, B2M
6MP:00053877.2FLT3, MPL, B2M, THPO, PDGFRB, JAK2

Publications for Chronic Myeloproliferative Disease

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Articles related to Chronic Myeloproliferative Disease:

(show all 38)
idTitleAuthorsYear
1
Reversible dilated cardiomyopathy associated with long-term anagrelide therapy in a patient with chronic myeloproliferative disease: a serial 2-dimensional speckle tracking echocardiographic study. (24698230)
2014
2
Fasting glucose level reduction induced by imatinib in chronic myeloproliferative disease with TEL-PDGFRI^ rearrangement and type 1 diabetes. (22623162)
2012
3
Inferior vena cava thrombosis and its relationship with the JAK2V617F mutation and chronic myeloproliferative disease. (21982959)
2012
4
Plasma levels of JAK2 mRNA in patients with chronic myeloproliferative diseases with and without V617F mutation: implications for prognosis and disease biology. (19254349)
2010
5
Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases. (18972067)
2009
6
Mutations in the JAK2 and MPL genes and their correlation to clinical parameters in patients with chronic myeloproliferative disease. (19372714)
2009
7
Philadelphia chromosome-negative chronic myeloproliferative disease. (19605821)
2009
8
Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation. (19196872)
2009
9
HFE C282Y mutation as a genetic modifier influencing disease susceptibility for chronic myeloproliferative disease. (19258483)
2009
10
Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate. (18421200)
2008
11
Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation. (17972958)
2008
12
A novel ETV6-PDGFRB fusion transcript missed by standard screening in a patient with an imatinib responsive chronic myeloproliferative disease. (17508004)
2007
13
Improvement of fibrosis in a patient with chronic myeloproliferative disease. (17910624)
2007
14
Molecular diagnosis of chronic myeloproliferative diseases and myelodysplastic syndromes]. (18314608)
2007
15
Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation. (17376889)
2007
16
Serum levels, and bone marrow immunohistochemical expression of, vascular endothelial growth factor in patients with chronic myeloproliferative diseases. (17852434)
2007
17
Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis. (17707884)
2007
18
Donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) after cord blood transplantation in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. (17875537)
2007
19
Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation. (17449802)
2007
20
Hyperhomocysteinemia--one of the factors underlying thrombotic complications in patients with chronic myeloproliferative diseases]. (18220034)
2007
21
Diagnostic algorithm in chronic myeloproliferative diseases (CMPD)]. (17879017)
2007
22
Recent advances in the bcr-abl negative chronic myeloproliferative diseases. (17032464)
2006
23
Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? (17178662)
2006
24
Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases. (16445842)
2006
25
SDF1-3'A gene polymorphism is associated with chronic myeloproliferative disease and thrombotic events. (16306115)
2005
26
Localized cutaneous cryptococcosis in a patient with chronic myeloproliferative disease. (16334871)
2005
27
Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. (15618966)
2005
28
Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases. (16115126)
2005
29
Inv(1)(p22q25) in chronic myeloproliferative disease: constitutional or clonal defect? (15796968)
2005
30
A rapidly progressive chronic myeloproliferative disease with isolated trisomy 6. (15036897)
2004
31
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet- derived growth factor receptor beta. (12181402)
2002
32
The role of morphology, cytochemistry and immunohistochemistry in the diagnosis of chronic myeloproliferative diseases. (12430892)
2002
33
Angiogenesis in chronic myeloproliferative diseases. (11815715)
2001
34
Clonality analysis using X-chromosome inactivation at the human androgen receptor gene (Humara). Evaluation of large cohorts of patients with chronic myeloproliferative diseases, secondary neutrophilia, and reactive thrombocytosis. (10396290)
1999
35
N-RAS activation in the terminal stage of undifferentiated chronic myeloproliferative disease. (1391809)
1992
36
Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells. (1682923)
1991
37
Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease. (2397474)
1990
38
Functional and morphological studies of platelet reactivity with vessel wall subendothelium in chronic myeloproliferative disease. (6944099)
1981

Variations for Chronic Myeloproliferative Disease

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Expression for genes affiliated with Chronic Myeloproliferative Disease

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Search GEO for disease gene expression data for Chronic Myeloproliferative Disease.

Pathways for genes affiliated with Chronic Myeloproliferative Disease

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Pathways related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MPL, THPO
29.4PDGFRB, JAK2
3
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4JAK2, PDGFRB
4
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.4JAK2, PDGFRB
5
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.3B2M, JAK2
6
Show member pathways
9.2FLT3, PDGFRB
79.1THPO, FLT3
8
Show member pathways
9.0FLT3, JAK2
9
Show member pathways
8.9PDGFRB, JAK2, THPO
10
Show member pathways
8.9JAK2, PDGFRB, THPO
11
Show member pathways
8.9THPO, MPL, JAK2
12
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
8.9JAK2, THPO, MPL
13
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.9MPL, JAK2, THPO
14
Show member pathways
8.7PDGFRB, FLT3, THPO
15
Show member pathways
8.7FLT3, THPO, PDGFRB
16
Show member pathways
8.7FLT3, THPO, PDGFRB
178.6JAK2, PDGFRB, FLT3
18
Show member pathways
8.2PDGFRB, JAK2, FLT3, MPL
19
Show member pathways
8.1JAK2, FLT3, THPO, PDGFRB
20
Show member pathways
8.1PDGFRB, JAK2, FLT3, THPO
21
Show member pathways
8.1FLT3, JAK2, PDGFRB, THPO
22
Show member pathways
7.6THPO, JAK2, MPL, FLT3, PDGFRB

Compounds for genes affiliated with Chronic Myeloproliferative Disease

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Compounds related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1megapoietin459.9MPL, THPO
2ifosfamide45 1310.7B2M, THPO
3pkc 412459.6PDGFRB, FLT3
4ag-1296459.6PDGFRB, FLT3
5phorbol 12,13-dibutyrate459.6THPO, JAK2
6ang ii459.6JAK2, PDGFRB
7su5416459.6FLT3, PDGFRB
8sunitinib45 51 1311.6FLT3, PDGFRB
9pixy321459.5THPO, FLT3
105fluorouracil459.5THPO, MPL, PDGFRB
11lestaurtinib45 6110.4FLT3, JAK2
12anagrelide45 1310.3JAK2, MPL, THPO
13sorafenib45 51 1311.3PDGFRB, FLT3
14matrigel459.3THPO, JAK2, PDGFRB
15methylcellulose459.3THPO, FLT3
16aspirin45 51 30 2612.2MPL, JAK2, THPO
17ly294002459.2THPO, JAK2, PDGFRB
18iron45 2610.2THPO, B2M, MPL
19wortmannin459.2THPO, PDGFRB, JAK2
20thromboxane45 2610.2THPO, MPL
21indomethacin45 30 61 1312.1THPO, JAK2, B2M
22butyrate459.1JAK2, B2M, THPO
23tgf beta1459.1PDGFRB, FLT3, THPO
24lysine459.1THPO, MPL, JAK2
25cisplatin45 51 61 1312.0PDGFRB, B2M, JAK2
26phosphotyrosine459.0JAK2, PDGFRB, FLT3
27h2o2458.9PDGFRB, JAK2, THPO
28agar458.9MPL, THPO, PDGFRB, JAK2
295-aza-2deoxycytidine458.9JAK2, FLT3, THPO
30phosphoinositide458.9PDGFRB, FLT3, JAK2
31genistein45 30 61 3 26 1313.8JAK2, PDGFRB, THPO, B2M
32lactate458.8B2M, THPO, FLT3
33estrogen458.8PDGFRB, B2M, THPO, JAK2
34glucose458.7PDGFRB, JAK2, B2M, THPO
35threonine458.6FLT3, MPL, JAK2, PDGFRB
36imatinib45 51 1310.5THPO, PDGFRB, JAK2, FLT3
37rapamycin458.5JAK2, FLT3, PDGFRB, THPO
38aspartate458.5B2M, FLT3, JAK2
39oligonucleotide458.5THPO, FLT3, PDGFRB, JAK2
40atp45 309.5THPO, FLT3, JAK2, PDGFRB
41thymidine45 269.4B2M, JAK2, FLT3, THPO
42alanine458.4THPO, JAK2, PDGFRB, B2M, MPL
43cysteine458.4JAK2, B2M, THPO, MPL, PDGFRB
44serine458.4MPL, JAK2, B2M, PDGFRB
45gp 130458.1FLT3, MPL, JAK2, THPO, PDGFRB
46phosphatidylinositol458.1PDGFRB, JAK2, MPL, FLT3, THPO
47adp45 30 2610.1MPL, FLT3, JAK2, THPO, PDGFRB
48tyrosine458.1JAK2, PDGFRB, FLT3, THPO, MPL
49retinoic acid45 269.0PDGFRB, FLT3, JAK2, B2M, THPO
50vegf457.6FLT3, THPO, B2M, MPL, JAK2, PDGFRB

GO Terms for genes affiliated with Chronic Myeloproliferative Disease

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Biological processes related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphoprotein phosphatase activityGO:00325169.7PDGFRB, JAK2
2platelet-derived growth factor receptor signaling pathwayGO:00480089.6JAK2, PDGFRB
3positive regulation of cell migrationGO:00303359.4PDGFRB, JAK2
4positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.4PDGFRB, FLT3
5positive regulation of MAP kinase activityGO:00434069.4PDGFRB, FLT3
6positive regulation of ERK1 and ERK2 cascadeGO:00703749.2PDGFRB, THPO
7interferon-gamma-mediated signaling pathwayGO:00603339.2JAK2, B2M
8positive regulation of phosphatidylinositol 3-kinase signalingGO:00140688.9PDGFRB, JAK2, FLT3
9blood coagulationGO:00075968.9THPO, MPL, JAK2
10peptidyl-tyrosine phosphorylationGO:00181088.9PDGFRB, JAK2, FLT3
11protein autophosphorylationGO:00467778.8FLT3, JAK2, PDGFRB
12cytokine-mediated signaling pathwayGO:00192218.7JAK2, FLT3, B2M
13positive regulation of cell proliferationGO:00082848.7PDGFRB, JAK2, FLT3

Molecular functions related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.4PDGFRB, JAK2
2cytokine receptor activityGO:00048968.9FLT3, MPL
3phosphatidylinositol 3-kinase bindingGO:00435488.5PDGFRB, JAK2, FLT3

Products for genes affiliated with Chronic Myeloproliferative Disease

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Sources for Chronic Myeloproliferative Disease

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet