CMPD
MCID: CHR092
MIFTS: 50

Chronic Myeloproliferative Disease (CMPD) malady

Rare diseases, Cancer diseases, Immune diseases categories
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Summaries for Chronic Myeloproliferative Disease

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NIH Rare Diseases:42 Chronic myeloproliferative disorders are a group of slow-growing blood cancers in which the bone marrow makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in the blood. the type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others are.there are 6 types of chronic myeloproliferative disorders: chronic myelogenous leukemia (cml), polycythemia vera, primary myelofibrosis (also called chronic idiopathic myelofibrosis), essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. chronic myeloproliferative disorders sometimes become acute leukemia, in which too many abnormal white blood cells are made. last updated: 3/31/2011

MalaCards based summary: Chronic Myeloproliferative Disease, also known as chronic myeloproliferative disorders, is related to erythrocytosis and polycythemia. An important gene associated with Chronic Myeloproliferative Disease is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Integrin alphaIIb beta3 signaling and Immune response IL 23 signaling pathway. The compounds megapoietin and ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and neutrophil, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

Aliases & Classifications for Chronic Myeloproliferative Disease

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Chronic Myeloproliferative Disease, Aliases & Descriptions:

Name: Chronic Myeloproliferative Disease 8 10 44
Chronic Myeloproliferative Disorders 42 62
Chronic Myeloproliferative Disorder 62
 
Campomelic Dysplasia 62
Cmpd, U 8
Cmpd 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:2226
NCIt39 C4345

Related Diseases for Chronic Myeloproliferative Disease

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Diseases in the Chronic Myeloproliferative Disease family:

8p11 Myeloproliferative Syndrome

Diseases related to Chronic Myeloproliferative Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1erythrocytosis30.4JAK2, MPL
2polycythemia30.3JAK2, THPO, MPL
3myelofibrosis30.3JAK2, THPO
4eosinophilia30.3PDGFRB, JAK2
5pdgfrb-associated chronic eosinophilic leukemia30.3PDGFRB, JAK2, MPL, FLT3
6bone marrow cancer30.1PDGFRB, JAK2, MPL
7acute leukemia29.6THPO, MPL, FLT3, JAK2
8myeloid leukemia29.6MPL, THPO, FLT3, JAK2
9thrombocytosis29.5FLT3, MPL, THPO, JAK2
10acute lymphoblastic leukemia29.5JAK2, FLT3, MPL, THPO
11polycythemia vera29.4PDGFRB, JAK2, FLT3, MPL, THPO
12chronic myeloid leukemia29.3FLT3, JAK2, THPO, PDGFRB, MPL
13myelodysplastic syndromes29.3JAK2, PDGFRB, THPO, MPL, FLT3
14leukemia29.1MPL, B2M, THPO, FLT3, JAK2, PDGFRB
15thrombocythemia 110.4THPO
16purpura10.4THPO
17synovitis10.3B2M
18unclassified chronic myeloproliferative disease10.3
19cerebritis10.3
20essential thrombocythemia10.3
21venous thrombosis10.3
22campomelic dysplasia10.2
23congenital amegakaryocytic thrombocytopenia10.2THPO, MPL
24thrombocytopenia due to platelet alloimmunization10.2THPO, MPL
25autoimmune thrombocytopenic purpura10.2MPL, THPO
26pancytopenia10.2THPO, MPL
27systemic mastocytosis10.2PDGFRB, JAK2
28erythromelalgia10.1
29portal vein thrombosis10.1
30paraplegia10.1
315q- syndrome10.1
32thromboembolism10.1
33tetrasomy 2110.1
34hepatoblastoma10.1THPO, MPL
35severe congenital neutropenia10.1JAK2, THPO
36neutropenia10.1THPO, MPL
37dilated cardiomyopathy10.1
38hyperhomocysteinemia10.1
39cryptococcosis10.1
40lymphoblastic leukemia10.1
41endotheliitis10.1
42gastrointestinal stromal tumor10.0PDGFRB, FLT3
43thrombocytopenia10.0MPL, THPO
44splenomegaly9.9JAK2, MPL, THPO
45hemorrhagic thrombocythemia9.9MPL, JAK2, THPO
46acute erythroid leukemia9.9THPO, MPL, JAK2
47factor v leiden thrombophilia9.9MPL, THPO, JAK2
48liver cirrhosis9.9THPO, MPL
49sarcoma9.9THPO, JAK2, PDGFRB
50aplastic anemia9.9FLT3, MPL, THPO

Graphical network of the top 20 diseases related to Chronic Myeloproliferative Disease:



Diseases related to chronic myeloproliferative disease

Symptoms for Chronic Myeloproliferative Disease

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Drugs & Therapeutics for Chronic Myeloproliferative Disease

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Drug clinical trials:

Search ClinicalTrials for Chronic Myeloproliferative Disease

Search NIH Clinical Center for Chronic Myeloproliferative Disease

Genetic Tests for Chronic Myeloproliferative Disease

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Anatomical Context for Chronic Myeloproliferative Disease

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MalaCards organs/tissues related to Chronic Myeloproliferative Disease:

32
Bone, Bone marrow, Neutrophil, Spleen, Myeloid, Endothelial

Animal Models for Chronic Myeloproliferative Disease or affiliated genes

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MGI Mouse Phenotypes related to Chronic Myeloproliferative Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6B2M, MPL, FLT3, JAK2, PDGFRB
2MP:00107687.6PDGFRB, JAK2, FLT3, MPL, B2M
3MP:00053787.5PDGFRB, JAK2, FLT3, MPL, B2M
4MP:00053767.3B2M, MPL, FLT3, JAK2, PDGFRB
5MP:00053977.2PDGFRB, JAK2, FLT3, MPL, B2M, THPO
6MP:00053877.2THPO, B2M, MPL, FLT3, JAK2, PDGFRB

Publications for Chronic Myeloproliferative Disease

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Articles related to Chronic Myeloproliferative Disease:

(show all 38)
idTitleAuthorsYear
1
Reversible dilated cardiomyopathy associated with long-term anagrelide therapy in a patient with chronic myeloproliferative disease: a serial 2-dimensional speckle tracking echocardiographic study. (24698230)
2014
2
Fasting glucose level reduction induced by imatinib in chronic myeloproliferative disease with TEL-PDGFRI^ rearrangement and type 1 diabetes. (22623162)
2012
3
Inferior vena cava thrombosis and its relationship with the JAK2V617F mutation and chronic myeloproliferative disease. (21982959)
2012
4
Plasma levels of JAK2 mRNA in patients with chronic myeloproliferative diseases with and without V617F mutation: implications for prognosis and disease biology. (19254349)
2010
5
Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases. (18972067)
2009
6
Mutations in the JAK2 and MPL genes and their correlation to clinical parameters in patients with chronic myeloproliferative disease. (19372714)
2009
7
Philadelphia chromosome-negative chronic myeloproliferative disease. (19605821)
2009
8
Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation. (19196872)
2009
9
HFE C282Y mutation as a genetic modifier influencing disease susceptibility for chronic myeloproliferative disease. (19258483)
2009
10
Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate. (18421200)
2008
11
Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation. (17972958)
2008
12
A novel ETV6-PDGFRB fusion transcript missed by standard screening in a patient with an imatinib responsive chronic myeloproliferative disease. (17508004)
2007
13
Improvement of fibrosis in a patient with chronic myeloproliferative disease. (17910624)
2007
14
Molecular diagnosis of chronic myeloproliferative diseases and myelodysplastic syndromes]. (18314608)
2007
15
Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation. (17376889)
2007
16
Serum levels, and bone marrow immunohistochemical expression of, vascular endothelial growth factor in patients with chronic myeloproliferative diseases. (17852434)
2007
17
Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis. (17707884)
2007
18
Donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) after cord blood transplantation in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. (17875537)
2007
19
Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation. (17449802)
2007
20
Hyperhomocysteinemia--one of the factors underlying thrombotic complications in patients with chronic myeloproliferative diseases]. (18220034)
2007
21
Diagnostic algorithm in chronic myeloproliferative diseases (CMPD)]. (17879017)
2007
22
Recent advances in the bcr-abl negative chronic myeloproliferative diseases. (17032464)
2006
23
Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? (17178662)
2006
24
Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases. (16445842)
2006
25
SDF1-3'A gene polymorphism is associated with chronic myeloproliferative disease and thrombotic events. (16306115)
2005
26
Localized cutaneous cryptococcosis in a patient with chronic myeloproliferative disease. (16334871)
2005
27
Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. (15618966)
2005
28
Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases. (16115126)
2005
29
Inv(1)(p22q25) in chronic myeloproliferative disease: constitutional or clonal defect? (15796968)
2005
30
A rapidly progressive chronic myeloproliferative disease with isolated trisomy 6. (15036897)
2004
31
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet- derived growth factor receptor beta. (12181402)
2002
32
The role of morphology, cytochemistry and immunohistochemistry in the diagnosis of chronic myeloproliferative diseases. (12430892)
2002
33
Angiogenesis in chronic myeloproliferative diseases. (11815715)
2001
34
Clonality analysis using X-chromosome inactivation at the human androgen receptor gene (Humara). Evaluation of large cohorts of patients with chronic myeloproliferative diseases, secondary neutrophilia, and reactive thrombocytosis. (10396290)
1999
35
N-RAS activation in the terminal stage of undifferentiated chronic myeloproliferative disease. (1391809)
1992
36
Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells. (1682923)
1991
37
Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease. (2397474)
1990
38
Functional and morphological studies of platelet reactivity with vessel wall subendothelium in chronic myeloproliferative disease. (6944099)
1981

Variations for Chronic Myeloproliferative Disease

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Expression for genes affiliated with Chronic Myeloproliferative Disease

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Expression patterns in normal tissues for genes affiliated with Chronic Myeloproliferative Disease

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Pathways for genes affiliated with Chronic Myeloproliferative Disease

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Pathways related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MPL, THPO
2
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4PDGFRB, JAK2
3
Show member pathways
S1P2 pathway37
S1P4 pathway37
S1P5 pathway37
S1P1 pathway37
Sphingosine 1-phosphate (S1P) pathway37
9.4PDGFRB, JAK2
49.4JAK2, PDGFRB
5
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.3JAK2, B2M
6
Show member pathways
9.2FLT3, PDGFRB
79.1FLT3, THPO
8
Show member pathways
9.0JAK2, FLT3
9
Show member pathways
8.9THPO, JAK2, PDGFRB
10
Show member pathways
8.9THPO, JAK2, PDGFRB
11
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.9THPO, MPL, JAK2
12
Show member pathways
8.9JAK2, MPL, THPO
13
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
8.9JAK2, MPL, THPO
14
Show member pathways
8.7PDGFRB, FLT3, THPO
15
Show member pathways
8.7THPO, FLT3, PDGFRB
16
Show member pathways
8.7THPO, FLT3, PDGFRB
178.6FLT3, JAK2, PDGFRB
18
Show member pathways
8.2PDGFRB, JAK2, FLT3, MPL
19
Show member pathways
8.1THPO, FLT3, JAK2, PDGFRB
20
Show member pathways
8.1PDGFRB, JAK2, FLT3, THPO
21
Show member pathways
8.1PDGFRB, JAK2, FLT3, THPO
22
Show member pathways
7.6PDGFRB, JAK2, FLT3, MPL, THPO

Compounds for genes affiliated with Chronic Myeloproliferative Disease

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Compounds related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1megapoietin449.9MPL, THPO
2ifosfamide44 1110.7B2M, THPO
3pkc 412449.6PDGFRB, FLT3
4ag-1296449.6PDGFRB, FLT3
5phorbol 12,13-dibutyrate449.6THPO, JAK2
6ang ii449.6JAK2, PDGFRB
7su5416449.6FLT3, PDGFRB
8sunitinib44 50 1111.6FLT3, PDGFRB
9pixy321449.5THPO, FLT3
105fluorouracil449.5THPO, MPL, PDGFRB
11lestaurtinib44 6110.4FLT3, JAK2
12anagrelide44 1110.3JAK2, MPL, THPO
13sorafenib44 50 1111.3PDGFRB, FLT3
14matrigel449.3THPO, JAK2, PDGFRB
15methylcellulose449.3THPO, FLT3
16aspirin44 50 28 2412.2MPL, JAK2, THPO
17ly294002449.2THPO, JAK2, PDGFRB
18iron44 2410.2THPO, B2M, MPL
19wortmannin449.2THPO, PDGFRB, JAK2
20thromboxane44 2410.2THPO, MPL
21indomethacin44 28 61 1112.1THPO, JAK2, B2M
22butyrate449.1JAK2, B2M, THPO
23tgf beta1449.1PDGFRB, FLT3, THPO
24lysine449.1THPO, MPL, JAK2
25cisplatin44 50 61 1112.0PDGFRB, B2M, JAK2
26phosphotyrosine449.0JAK2, PDGFRB, FLT3
27h2o2448.9PDGFRB, JAK2, THPO
28agar448.9MPL, THPO, PDGFRB, JAK2
295-aza-2deoxycytidine448.9JAK2, FLT3, THPO
30phosphoinositide448.9PDGFRB, FLT3, JAK2
31genistein44 28 61 2 24 1113.8JAK2, PDGFRB, THPO, B2M
32lactate448.8B2M, THPO, FLT3
33estrogen448.8PDGFRB, B2M, THPO, JAK2
34glucose448.7PDGFRB, JAK2, B2M, THPO
35threonine448.6FLT3, MPL, JAK2, PDGFRB
36imatinib44 50 1110.5THPO, PDGFRB, JAK2, FLT3
37rapamycin448.5JAK2, FLT3, PDGFRB, THPO
38aspartate448.5B2M, FLT3, JAK2
39oligonucleotide448.5THPO, FLT3, PDGFRB, JAK2
40atp44 289.5THPO, FLT3, JAK2, PDGFRB
41thymidine44 249.4B2M, JAK2, FLT3, THPO
42alanine448.4THPO, JAK2, PDGFRB, B2M, MPL
43cysteine448.4JAK2, B2M, THPO, MPL, PDGFRB
44serine448.4MPL, JAK2, B2M, PDGFRB
45gp 130448.1FLT3, MPL, JAK2, THPO, PDGFRB
46phosphatidylinositol448.1PDGFRB, JAK2, MPL, FLT3, THPO
47adp44 28 2410.1MPL, FLT3, JAK2, THPO, PDGFRB
48tyrosine448.1JAK2, PDGFRB, FLT3, THPO, MPL
49retinoic acid44 249.0PDGFRB, FLT3, JAK2, B2M, THPO
50vegf447.6FLT3, THPO, B2M, MPL, JAK2, PDGFRB

GO Terms for genes affiliated with Chronic Myeloproliferative Disease

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Biological processes related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphoprotein phosphatase activityGO:0325169.7PDGFRB, JAK2
2platelet-derived growth factor receptor signaling pathwayGO:0480089.6JAK2, PDGFRB
3positive regulation of cell migrationGO:0303359.4PDGFRB, JAK2
4positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.4PDGFRB, FLT3
5positive regulation of MAP kinase activityGO:0434069.4PDGFRB, FLT3
6positive regulation of ERK1 and ERK2 cascadeGO:0703749.2PDGFRB, THPO
7interferon-gamma-mediated signaling pathwayGO:0603339.2JAK2, B2M
8positive regulation of phosphatidylinositol 3-kinase signalingGO:0140688.9PDGFRB, JAK2, FLT3
9blood coagulationGO:0075968.9THPO, MPL, JAK2
10peptidyl-tyrosine phosphorylationGO:0181088.9PDGFRB, JAK2, FLT3
11protein autophosphorylationGO:0467778.8FLT3, JAK2, PDGFRB
12cytokine-mediated signaling pathwayGO:0192218.7JAK2, FLT3, B2M
13positive regulation of cell proliferationGO:0082848.7PDGFRB, JAK2, FLT3

Molecular functions related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.4PDGFRB, JAK2
2cytokine receptor activityGO:0048968.9FLT3, MPL
3phosphatidylinositol 3-kinase bindingGO:0435488.5PDGFRB, JAK2, FLT3

Products for genes affiliated with Chronic Myeloproliferative Disease

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Sources for Chronic Myeloproliferative Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet