CMPD
MCID: CHR092
MIFTS: 55

Chronic Myeloproliferative Disease (CMPD) malady

Cancer diseases category

Summaries for Chronic Myeloproliferative Disease

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8Disease Ontology, 42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Chronic myeloproliferative disorders are a group of slow-growing blood cancers in which the bone marrow makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in the blood. the type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others are.there are 6 types of chronic myeloproliferative disorders: chronic myelogenous leukemia (cml), polycythemia vera, primary myelofibrosis (also called chronic idiopathic myelofibrosis), essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. chronic myeloproliferative disorders sometimes become acute leukemia, in which too many abnormal white blood cells are made. last updated: 3/31/2011

MalaCards: Chronic Myeloproliferative Disease, also known as chronic myeloproliferative disorders, is related to polycythemia and leukemia. An important gene associated with Chronic Myeloproliferative Disease is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are TGF-Beta Pathway and ErbB4 signaling events. The compounds glucose and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related mouse phenotypes are integument and tumorigenesis.

Disease Ontology:8 A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

Aliases & Classifications for Chronic Myeloproliferative Disease

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60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 42NIH Rare Diseases, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

chronic myeloproliferative disease 8 10 44
chronic myeloproliferative disorders 42
chronic myeloproliferative disorder 60
campomelic dysplasia 60
cmpd, u 8
cmpd 8


External Ids:

Disease Ontology8 DOID:2226
NCIt39 C4345
ICD1025 D47.1

Related Diseases for Chronic Myeloproliferative Disease

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17GeneCards, 18GeneDecks
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Diseases in the Chronic Myeloproliferative Disease family:

8p11 Myeloproliferative Syndrome Myeloproliferative Disorder

Diseases related to Chronic Myeloproliferative Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1polycythemia30.3TFRC, STAT5A, CD177, THPO, MPL, JAK2
2leukemia30.3MPO, HFE, FLT3, STAT3, B2M, MPL
3myelofibrosis30.1THPO, JAK2
4vascular disease30.1JAK2, STAT3
5thrombocytosis30.1FLT3, CD177, MPL, JAK2, THPO
6polycythemia vera30.1PDGFRB, PDGFRA, JAK2, CD177, THPO, MPL
7myeloid leukemia30.1THPO, MPL, MPO, FLT3, STAT3, STAT5B
8eosinophilia30.1PDGFRB, PDGFRA, IL2RA, JAK2, MPO
9myeloproliferative disorder30.1PDGFRB, PDGFRA, JAK2, THPO, CD177, MPL
10chronic myeloid leukemia30.1STAT5A, JAK2, PDGFRA, PDGFRB, STAT5B, FLT3
11acute leukemia30.1MPO, STAT5A, STAT5B, JAK2, FLT3, MPL
12campomelic dysplasia11.2
13chromosomal disease10.4
14campomelic dysplasia with autosomal sex reversal10.3
15pdgfrb-associated chronic eosinophilic leukemia10.3
16unclassified chronic myeloproliferative disease10.3
17pierre robin sequence with pectus excavatum and rib and scapular anomalies10.3
18cerebritis10.2
19conversion disorder10.1
20gonadoblastoma10.1
21malignant hyperthermia10.1
22nephrocalcinosis10.1
23osteogenesis imperfecta10.1
24hermaphroditism10.1
25myh7-related dilated cardiomyopathy10.1
26tpm1-related dilated cardiomyopathy10.1
27erythromelalgia10.1
28portal vein thrombosis10.1
29paraplegia10.1
30acute t cell leukemia10.1
31hyperhomocysteinemia10.1
32cryptococcosis10.1
33lymphoblastic leukemia10.1
34splenic disease10.1
35multiple myeloma10.0B2M
36neuroblastoma10.0CD177
37thyroid cancer10.0FLT3
38meningioma10.0PDGFRB
39thromboembolism10.0F7
40stomach cancer10.0STAT3
41sickle cell disease10.0TFRC
42synovitis10.0B2M
43pancreatitis10.0MPO
44hemorrhagic thrombocythemia10.0CD177
45pneumonia10.0MPO
46viral hepatitis10.0HFE
47down syndrome10.0FLT3, JAK2
48autoimmune thrombocytopenic purpura10.0THPO, MPL
49common variable immune deficiency10.0IL2RA
50pancreatic cancer10.0STAT3, PDGFRB

Graphical network of the top 20 diseases related to Chronic Myeloproliferative Disease:



Diseases related to chronic myeloproliferative disease

Clinical Features for Chronic Myeloproliferative Disease

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Drugs & Therapeutics for Chronic Myeloproliferative Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Myeloproliferative Disease

Drug clinical trials:

Search ClinicalTrials for Chronic Myeloproliferative Disease

Search NIH Clinical Center for Chronic Myeloproliferative Disease

Search CenterWatch for Chronic Myeloproliferative Disease

Genetic Tests for Chronic Myeloproliferative Disease

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Anatomical Context for Chronic Myeloproliferative Disease

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32MalaCards
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MalaCards organs/tissues related to Chronic Myeloproliferative Disease:

32
Bone, Bone marrow, Myeloid, Spleen, Endothelial

Animal Models for Chronic Myeloproliferative Disease or affiliated genes

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36MGI
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Publications for Chronic Myeloproliferative Disease

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50PubMed
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Articles related to Chronic Myeloproliferative Disease:

(show all 46)
idTitleAuthorsYear
1
Fasting glucose level reduction induced by imatinib in chronic myeloproliferative disease with TEL-PDGFRI^ rearrangement and type 1 diabetes. (22623162)
2012
2
Inferior vena cava thrombosis and its relationship with the JAK2V617F mutation and chronic myeloproliferative disease. (21982959)
2012
3
Plasma levels of JAK2 mRNA in patients with chronic myeloproliferative diseases with and without V617F mutation: implications for prognosis and disease biology. (19254349)
2010
4
LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. (20724988)
2010
5
Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases. (18972067)
2009
6
Mutations in the JAK2 and MPL genes and their correlation to clinical parameters in patients with chronic myeloproliferative disease. (19372714)
2009
7
Philadelphia chromosome-negative chronic myeloproliferative disease. (19605821)
2009
8
Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation. (19196872)
2009
9
HFE C282Y mutation as a genetic modifier influencing disease susceptibility for chronic myeloproliferative disease. (19258483)
2009
10
Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate. (18421200)
2008
11
Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation. (17972958)
2008
12
A novel ETV6-PDGFRB fusion transcript missed by standard screening in a patient with an imatinib responsive chronic myeloproliferative disease. (17508004)
2007
13
Improvement of fibrosis in a patient with chronic myeloproliferative disease. (17910624)
2007
14
Molecular diagnosis of chronic myeloproliferative diseases and myelodysplastic syndromes]. (18314608)
2007
15
Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation. (17376889)
2007
16
Serum levels, and bone marrow immunohistochemical expression of, vascular endothelial growth factor in patients with chronic myeloproliferative diseases. (17852434)
2007
17
Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis. (17707884)
2007
18
Donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) after cord blood transplantation in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. (17875537)
2007
19
Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation. (17449802)
2007
20
Hyperhomocysteinemia--one of the factors underlying thrombotic complications in patients with chronic myeloproliferative diseases]. (18220034)
2007
21
Diagnostic algorithm in chronic myeloproliferative diseases (CMPD)]. (17879017)
2007
22
Recent advances in the bcr-abl negative chronic myeloproliferative diseases. (17032464)
2006
23
Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? (17178662)
2006
24
Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases. (16445842)
2006
25
Inclusion of secondary chronic myelomonocytic leukemia and myeloproliferative disease, unclassifiable, in classification of pediatric myeloproliferative disorders. (17023836)
2006
26
Association of plasma adiponectin concentrations with chronic lymphocytic leukemia and myeloproliferative diseases. (16720558)
2006
27
SDF1-3'A gene polymorphism is associated with chronic myeloproliferative disease and thrombotic events. (16306115)
2005
28
Refractory anemia with ringed sideroblasts and chronic myelomonocytic leukemia: myelodysplastic/myeloproliferative disease. (16174602)
2005
29
Localized cutaneous cryptococcosis in a patient with chronic myeloproliferative disease. (16334871)
2005
30
Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. (15618966)
2005
31
Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases. (16115126)
2005
32
Inv(1)(p22q25) in chronic myeloproliferative disease: constitutional or clonal defect? (15796968)
2005
33
Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice. (15213099)
2004
34
A rapidly progressive chronic myeloproliferative disease with isolated trisomy 6. (15036897)
2004
35
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet- derived growth factor receptor beta. (12181402)
2002
36
The role of morphology, cytochemistry and immunohistochemistry in the diagnosis of chronic myeloproliferative diseases. (12430892)
2002
37
Angiogenesis in chronic myeloproliferative diseases. (11815715)
2001
38
Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL. (11222392)
2001
39
Myelodysplastic and myeloproliferative type of chronic myelomonocytic leukemia--distinct subgroups or two stages of the same disease? (11337023)
2001
40
Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder. (10648600)
2000
41
Clonality analysis using X-chromosome inactivation at the human androgen receptor gene (Humara). Evaluation of large cohorts of patients with chronic myeloproliferative diseases, secondary neutrophilia, and reactive thrombocytosis. (10396290)
1999
42
Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia. (9808576)
1998
43
N-RAS activation in the terminal stage of undifferentiated chronic myeloproliferative disease. (1391809)
1992
44
Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells. (1682923)
1991
45
Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease. (2397474)
1990
46
Functional and morphological studies of platelet reactivity with vessel wall subendothelium in chronic myeloproliferative disease. (6944099)
1981

Genetic Variations for Chronic Myeloproliferative Disease

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Expression for genes affiliated with Chronic Myeloproliferative Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Myeloproliferative Disease

Search GEO for disease gene expression data for Chronic Myeloproliferative Disease.

Pathways for genes affiliated with Chronic Myeloproliferative Disease

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51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 12EMD Millipore, 53Reactome, 4Cell Signaling Technology
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Pathways related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0THPO, MPL, IL2RA
29.9JAK2, STAT5B, STAT5A
39.9STAT5B, STAT3, STAT5A
49.9STAT3, STAT5B, STAT5A
59.8LDHB, LDHA, LDHC
69.8LDHA, LDHB, LDHC
79.7TFRC, FLT3, IL2RA, THPO
89.7PDGFRB, STAT3, STAT5B, STAT5A
99.7STAT5B, STAT5A, PDGFRB, STAT3
10
Hide members
9.7JAK2, STAT5A, STAT5B, STAT3
11
Development Prolactin receptor signaling
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9.7JAK2, STAT5A, STAT5B, STAT3
12
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.7STAT5B, STAT3, JAK2, STAT5A
13
Development EPO-induced Jak-STAT pathway
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9.7STAT3, STAT5B, STAT5A, JAK2
14
Hide members
9.7JAK2, STAT5A, STAT3, STAT5B
159.7STAT3, STAT5B, STAT5A, JAK2
16
Hide members
9.7STAT5A, JAK2, STAT3, STAT5B
179.7STAT3, STAT5B, JAK2, STAT5A
189.7STAT5B, STAT5A, JAK2, STAT3
199.7STAT5A, JAK2, STAT5B, STAT3
20
Hide members
9.7STAT5B, STAT5A, JAK2, STAT3
21
Hide members
9.7STAT5A, STAT3, FLT3, STAT5B
22
Immune response IL-2 activation and signaling pathway
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9.6IL2RA, STAT5B, STAT5A, JAK2
23
Hide members
9.6STAT3, IL2RA, STAT5B, STAT5A
249.6PDGFRA, JAK2, FLT3, IL2RA, PDGFRB
259.6STAT3, STAT5B, STAT5A, JAK2, PDGFRB
26
Hide members
9.6STAT5A, STAT5B, STAT3, FLT3, JAK2
27
Hide members
9.5STAT5A, STAT3, B2M, IL2RA, JAK2
289.5JAK2, STAT5A, STAT5B, STAT3, IL2RA
299.5IL2RA, STAT3, STAT5B, STAT5A, JAK2
30
Hide members
9.5IL2RA, JAK2, STAT5B, STAT5A, STAT3
31
Hide members
9.5JAK2, IL2RA, STAT5A, STAT5B, STAT3
329.5IL2RA, JAK2, STAT5A, STAT3, STAT5B
33
Hide members
9.5PDGFRA, JAK2, IL2RA, THPO, PDGFRB, STAT3
34
Development Thrombopoetin signaling via JAK-STAT pathway
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9.4MPL, STAT3, STAT5B, STAT5A, JAK2, THPO
359.4STAT5A, STAT5B, PDGFRA, PDGFRB, IL2RA
36
Hide members
9.4STAT5A, STAT3, STAT5B, JAK2, PDGFRA, PDGFRB
37
Hide members
9.4JAK2, PDGFRA, PDGFRB, STAT5A, STAT5B, STAT3
389.4FLT3, PDGFRB, PDGFRA, STAT5B, STAT5A, STAT3
39
Hide members
9.3STAT5B, PDGFRB, STAT5A, STAT3, B2M, PDGFRA
409.3STAT5B, STAT5A, STAT3, MPL, IL2RA, JAK2
41
Hide members
9.3MPL, STAT5B, STAT5A, JAK2, STAT3, IL2RA
42
Hide members
9.3IL2RA, B2M, STAT3, STAT5A, STAT5B, JAK2
43
Hide members
9.2STAT5B, THPO, IL2RA, MPL, JAK2, STAT3
449.2STAT5A, PDGFRA, PDGFRB, STAT5B, STAT3, LDHB
45
Development PDGF signaling via STATs and NF-kB
Hide members
9.1JAK2, STAT5A, STAT5B, PDGFRB, STAT3, PDGFRA
46
Hide members
9.0MPL, IL2RA, STAT5B, STAT5A, JAK2, PDGFRA
47
Hide members
9.0PDGFRA, THPO, JAK2, STAT5A, STAT5B, STAT3
48
Hide members
9.0B2M, PDGFRA, STAT3, STAT5B, STAT5A, JAK2
49
Hide members
8.8JAK2, THPO, FLT3, STAT3, STAT5B, STAT5A
50
Hide members
8.8PDGFRA, JAK2, STAT5A, STAT5B, THPO, STAT3

Compounds for genes affiliated with Chronic Myeloproliferative Disease

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1glucose4410.8PDGFRB
2estrogen4410.8THPO
3anagrelide44 1111.4JAK2, MPL, THPO
4creatinine4410.2THPO, F7, LDHC
5cucurbitacin i44 5911.2STAT3, JAK2
6su54164410.2STAT3, STAT5A, PDGFRB, FLT3
7pkc 4124410.1FLT3, STAT5A, PDGFRB, PDGFRA
8ag-12964410.1FLT3, PDGFRA, STAT5A, PDGFRB
9dasatinib44 49 1112.1STAT3, STAT5A, STAT5B, PDGFRB
10vanadate4410.0PDGFRB, STAT5A, STAT3, JAK2
11vitamin-e4410.0IL2RA, F7, STAT3, JAK2, B2M
12matrigel449.9PDGFRB, STAT3, JAK2, STAT5A
13polyethylene glycol449.9THPO, MPO, TFRC, MPL
14arsenite44 2410.9STAT3, JAK2, STAT5B, TFRC, FLT3
15sunitinib44 49 1111.9PDGFRB, PDGFRA, FLT3
16hydroxyurea44 49 1111.9PDGFRA, JAK2, THPO, TFRC
17agar449.8THPO, MPL, PDGFRB, JAK2, STAT3, STAT5A
185fluorouracil449.8PDGFRB, STAT3, MPO, MPL, IL2RA, THPO
19cytarabine44 49 1111.8TFRC, FLT3, MPO, THPO, STAT5A
20calcitriol44 59 11 2412.8TFRC, B2M, PDGFRB, IL2RA, PDGFRA
21herbimycin a44 5910.7IL2RA, FLT3, JAK2, TFRC, STAT5A
22butyrate449.7JAK2, B2M, THPO
23phosphotyrosine449.6STAT5B, FLT3, STAT3, PDGFRB, STAT5A, JAK2
24ly294002449.6PDGFRB, THPO, STAT3, STAT5B, STAT5A, TFRC
25wortmannin449.6STAT5A, JAK2, PDGFRB, TFRC, THPO, STAT3
26serine449.6STAT5B, B2M, JAK2, STAT3, MPO, MPL
27iron44 2410.6THPO, HFE, MPL, TFRC, STAT3, B2M
28n acetylcysteine449.5STAT3, JAK2, TFRC, IL2RA, MPO
29imatinib44 49 1111.5THPO, FLT3, STAT3, STAT5B, STAT5A, JAK2
30cyclosporin a44 28 5911.5STAT3, IL2RA, JAK2, TFRC, STAT5A, B2M
31cisplatin44 49 59 1112.5STAT3, JAK2, IL2RA, MPO, PDGFRB, B2M
32paraffin449.5B2M, STAT3, TFRC, PDGFRA, PDGFRB, MPO
33h2o2449.5JAK2, THPO, IL2RA, MPO, PDGFRB, STAT3
34threonine449.4STAT3, PDGFRB, JAK2, STAT5A, STAT5B, MPL
35genistein44 28 59 2 11 2414.4THPO, PDGFRB, STAT3, STAT5A, TFRC, B2M
36ascorbic acid44 2410.4MPO, HFE, IL2RA, TFRC, JAK2
37oligonucleotide449.4THPO, JAK2, PDGFRA, STAT5A, PDGFRB, HFE
38testosterone44 59 11 2412.4LDHC, IL2RA, HFE, PDGFRB, TFRC, STAT3
39aspartate449.4JAK2, TFRC, STAT5A, FLT3, HFE, F7
40gp 130449.4STAT5B, THPO, IL2RA, MPL, STAT3, STAT5A
41lactate449.3THPO, LDHA, LDHC, TFRC, B2M, FLT3
42thymidine44 2410.2THPO, IL2RA, FLT3, STAT3, STAT5A, TFRC
43alanine449.1STAT5A, STAT3, THPO, HFE, B2M, MPL
44atp44 2810.1LDHA, LDHC, PDGFRB, PDGFRA, JAK2, STAT5A
45cysteine449.1THPO, B2M, IL2RA, STAT3, STAT5A, TFRC
46rapamycin449.1TFRC, STAT5B, STAT5A, PDGFRA, PDGFRB, JAK2
47phosphatidylinositol448.9STAT5A, PDGFRA, JAK2, TFRC, THPO, IL2RA
48retinoic acid44 249.9TFRC, PDGFRA, JAK2, STAT5A, PDGFRB, STAT5B
49vegf448.5THPO, IL2RA, MPL, MPO, B2M, PDGFRB
50tyrosine448.3IL2RA, THPO, LDHA, HFE, CD177, STAT5A

GO Terms for genes affiliated with Chronic Myeloproliferative Disease

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16Gene Ontology
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Cellular components related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:04261210.1HFE, B2M
2intrinsic to plasma membraneGO:0312269.8PDGFRA, PDGFRB
3external side of plasma membraneGO:0098979.5BCAM, IL2RA, B2M, TFRC, PDGFRA
4plasma membraneGO:0058868.4STAT3, TFRC, PDGFRA, PDGFRB, B2M, MPL

Biological processes related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:07227710.5PDGFRA, PDGFRB
2positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.5PDGFRB, PDGFRA
3growth hormone receptor signaling pathwayGO:06039610.5JAK2, STAT3
4retina vasculature development in camera-type eyeGO:06129810.5PDGFRB, PDGFRA
5positive regulation of phospholipase C activityGO:01086310.4PDGFRB, PDGFRA
6positive regulation of phosphoprotein phosphatase activityGO:03251610.4PDGFRB, JAK2
7development of secondary female sexual characteristicsGO:04654310.4STAT5A, STAT5B
8regulation of steroid metabolic processGO:01921810.4STAT5A, STAT5B
9platelet-derived growth factor receptor signaling pathwayGO:04800810.4PDGFRB, PDGFRA, JAK2
10prolactin signaling pathwayGO:03816110.4STAT5A, STAT5B
11development of secondary male sexual characteristicsGO:04654410.4STAT5B, STAT5A
12positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.4PDGFRB, PDGFRA, FLT3
13allantoin metabolic processGO:00025510.4STAT5B, STAT5A
14isoleucine metabolic processGO:00654910.4STAT5B, STAT5A
15mammary gland epithelium developmentGO:06118010.4JAK2, STAT5A
16creatinine metabolic processGO:04644910.4STAT5A, STAT5B
17regulation of epithelial cell differentiationGO:03085610.4STAT5A, STAT5B
18taurine metabolic processGO:01953010.4STAT5A, STAT5B
19valine metabolic processGO:00657310.4STAT5A, STAT5B
20positive regulation of gamma-delta T cell differentiationGO:04558810.4STAT5A, STAT5B
21citrate metabolic processGO:00610110.3STAT5A, STAT5B
22response to estradiol stimulusGO:03235510.3STAT3, STAT5B, PDGFRB
23positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.3FLT3, JAK2, PDGFRA, PDGFRB
24regulation of multicellular organism growthGO:04001410.3STAT3, STAT5B, STAT5A
25Peyers patch developmentGO:04854110.3STAT5A, STAT5B
26negative regulation of erythrocyte differentiationGO:04564710.3STAT5A, STAT5B
27T cell differentiation in thymusGO:03307710.3B2M, STAT5B, STAT5A
28positive regulation of inflammatory responseGO:05072910.2JAK2, STAT5A, STAT5B
29luteinizationGO:00155310.2PDGFRA, STAT5A, STAT5B
30succinate metabolic processGO:00610510.2STAT5A, STAT5B
31positive regulation of cell migrationGO:03033510.2PDGFRB, PDGFRA, JAK2, F7
32protein autophosphorylationGO:04677710.2FLT3, JAK2, PDGFRA, PDGFRB
33cellular carbohydrate metabolic processGO:04426210.2LDHB, LDHA, LDHC
34positive regulation of natural killer cell differentiationGO:03282510.2STAT5A, STAT5B
35positive regulation of activated T cell proliferationGO:04210410.2IL2RA, STAT5B, STAT5A
36oxaloacetate metabolic processGO:00610710.2STAT5A, STAT5B
37cytokine-mediated signaling pathwayGO:01922110.2JAK2, STAT3, FLT3, B2M
38glycolysisGO:00609610.2LDHB, LDHA, LDHC
39JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.2JAK2, STAT5A, STAT5B, STAT3
40JAK-STAT cascadeGO:00725910.2STAT3, STAT5B, STAT5A, JAK2
41cardiac myofibril assemblyGO:05500310.1PDGFRA, PDGFRB
42positive regulation of B cell differentiationGO:04557910.1STAT5A, STAT5B
43creatine metabolic processGO:00660010.1STAT5A, STAT5B
44blood coagulationGO:00759610.0THPO, F7, CD177, MPL, JAK2
45positive regulation of natural killer cell mediated cytotoxicityGO:04595410.0STAT5B, STAT5A
46peptidyl-tyrosine phosphorylationGO:01810810.0FLT3, STAT5A, JAK2, PDGFRA, PDGFRB
47female pregnancyGO:00756510.0HFE, STAT5B, STAT5A
48positive regulation of interleukin-2 biosynthetic processGO:0450869.9STAT5A, STAT5B
49natural killer cell differentiationGO:0017799.7STAT5A, STAT5B

Molecular functions related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.2PDGFRA, PDGFRB
2glucocorticoid receptor bindingGO:03525910.2STAT5B, STAT3
3phosphatidylinositol 3-kinase bindingGO:04354810.2PDGFRB, JAK2, FLT3
4platelet-derived growth factor receptor bindingGO:00516110.1PDGFRA, PDGFRB
5vascular endothelial growth factor-activated receptor activityGO:00502110.1PDGFRA, FLT3
6platelet-derived growth factor bindingGO:04840710.0PDGFRA, PDGFRB
7L-lactate dehydrogenase activityGO:00445910.0LDHC, LDHA, LDHB
8receptor bindingGO:0051029.5PDGFRB, JAK2, HFE, F7

Products for genes affiliated with Chronic Myeloproliferative Disease

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Sources for Chronic Myeloproliferative Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet