CMPD
MCID: CHR092
MIFTS: 50

Chronic Myeloproliferative Disease (CMPD) malady

Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Chronic Myeloproliferative Disease

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9Disease Ontology, 44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Chronic myeloproliferative disorders are a group of slow-growing blood cancers in which the bone marrowĀ makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in theĀ blood. the type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others are.there are 6 types of chronic myeloproliferative disorders: chronic myelogenous leukemiaĀ (cml), polycythemia vera, primary myelofibrosis (also called chronic idiopathic myelofibrosis), essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia. chronic myeloproliferative disorders sometimes become acute leukemia, in which too many abnormal white blood cells are made. last updated: 3/31/2011

MalaCards: Chronic Myeloproliferative Disease, also known as chronic myeloproliferative disorders, is related to polycythemia and erythrocytosis. An important gene associated with Chronic Myeloproliferative Disease is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are Integrin alphaIIb beta3 signaling and Immune response IL 23 signaling pathway. The compounds megapoietin and ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spleen, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:9 A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

Aliases & Classifications for Chronic Myeloproliferative Disease

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

chronic myeloproliferative disease 9 11 46
chronic myeloproliferative disorders 44
chronic myeloproliferative disorder 63
campomelic dysplasia 63
cmpd, u 9
cmpd 9


External Ids:

Disease Ontology9 DOID:2226
NCIt41 C4345
ICD1026 D47.1

Related Diseases for Chronic Myeloproliferative Disease

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18GeneCards, 19GeneDecks
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Diseases in the Chronic Myeloproliferative Disease family:

8p11 Myeloproliferative Syndrome Myeloproliferative Disorder

Diseases related to Chronic Myeloproliferative Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1polycythemia30.4THPO, MPL, JAK2
2erythrocytosis30.2MPL, JAK2
3myelofibrosis30.2THPO, JAK2
4eosinophilia30.1PDGFRB, JAK2
5myeloproliferative disorder30.1THPO, MPL, FLT3, JAK2, PDGFRB
6leukemia30.1THPO, B2M, MPL, FLT3, JAK2, PDGFRB
7acute leukemia30.0JAK2, FLT3, MPL, THPO
8myeloid leukemia30.0JAK2, FLT3, MPL, THPO
9polycythemia vera30.0THPO, MPL, FLT3, JAK2, PDGFRB
10chronic myeloid leukemia30.0PDGFRB, JAK2, FLT3, MPL, THPO
11thrombocytosis30.0THPO, MPL, FLT3, JAK2
12myelodysplastic syndromes29.9THPO, MPL, FLT3, JAK2, PDGFRB
13pdgfrb-associated chronic eosinophilic leukemia10.4
14unclassified chronic myeloproliferative disease10.3
15cerebritis10.3
16essential thrombocythemia10.3
17venous thrombosis10.3
18erythromelalgia10.1
19portal vein thrombosis10.1
20paraplegia10.1
215q- syndrome10.1
22thromboembolism10.1
23tetrasomy 2110.1
24thrombocythemia 110.1THPO
25purpura10.1THPO
26hyperhomocysteinemia10.1
27cryptococcosis10.1
28lymphoblastic leukemia10.1
29endotheliitis10.1
30synovitis10.1B2M
31congenital amegakaryocytic thrombocytopenia10.0MPL, THPO
32thrombocytopenia due to platelet alloimmunization10.0MPL, THPO
33campomelic dysplasia10.0
34autoimmune thrombocytopenic purpura10.0MPL, THPO
35pancytopenia10.0MPL, THPO
36systemic mastocytosis10.0PDGFRB, JAK2
37hepatoblastoma10.0THPO, MPL
38severe congenital neutropenia10.0THPO, JAK2
39neutropenia10.0THPO, MPL
40gastrointestinal stromal tumor10.0FLT3, PDGFRB
41thrombocytopenia10.0THPO, MPL
42hemorrhagic thrombocythemia10.0THPO, MPL, JAK2
43splenomegaly10.0THPO, MPL, JAK2
44acute erythroid leukemia10.0THPO, MPL, JAK2
45factor v leiden thrombophilia10.0THPO, MPL, JAK2
46liver cirrhosis10.0MPL, THPO
47sarcoma10.0PDGFRB, JAK2, THPO
48aplastic anemia10.0THPO, MPL, FLT3
49precursor t-cell acute lymphoblastic leukemia10.0JAK2, FLT3
50hodgkin's lymphoma10.0JAK2, FLT3

Graphical network of the top 20 diseases related to Chronic Myeloproliferative Disease:



Diseases related to chronic myeloproliferative disease

Symptoms for Chronic Myeloproliferative Disease

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Drugs & Therapeutics for Chronic Myeloproliferative Disease

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Myeloproliferative Disease

Drug clinical trials:

Search ClinicalTrials for Chronic Myeloproliferative Disease

Search NIH Clinical Center for Chronic Myeloproliferative Disease

Search CenterWatch for Chronic Myeloproliferative Disease

Genetic Tests for Chronic Myeloproliferative Disease

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Anatomical Context for Chronic Myeloproliferative Disease

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34MalaCards
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MalaCards organs/tissues related to Chronic Myeloproliferative Disease:

34
Bone, Bone marrow, Spleen, Myeloid, Endothelial

Animal Models for Chronic Myeloproliferative Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chronic Myeloproliferative Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6B2M, MPL, FLT3, JAK2, PDGFRB
2MP:00107687.6PDGFRB, JAK2, FLT3, MPL, B2M
3MP:00053787.5PDGFRB, JAK2, FLT3, MPL, B2M
4MP:00053767.3B2M, MPL, FLT3, JAK2, PDGFRB
5MP:00053977.2PDGFRB, JAK2, FLT3, MPL, B2M, THPO
6MP:00053877.2THPO, B2M, MPL, FLT3, JAK2, PDGFRB

Publications for Chronic Myeloproliferative Disease

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53PubMed
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Articles related to Chronic Myeloproliferative Disease:

(show all 37)
idTitleAuthorsYear
1
Fasting glucose level reduction induced by imatinib in chronic myeloproliferative disease with TEL-PDGFRI^ rearrangement and type 1 diabetes. (22623162)
2012
2
Inferior vena cava thrombosis and its relationship with the JAK2V617F mutation and chronic myeloproliferative disease. (21982959)
2012
3
Plasma levels of JAK2 mRNA in patients with chronic myeloproliferative diseases with and without V617F mutation: implications for prognosis and disease biology. (19254349)
2010
4
Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases. (18972067)
2009
5
Mutations in the JAK2 and MPL genes and their correlation to clinical parameters in patients with chronic myeloproliferative disease. (19372714)
2009
6
Philadelphia chromosome-negative chronic myeloproliferative disease. (19605821)
2009
7
Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation. (19196872)
2009
8
HFE C282Y mutation as a genetic modifier influencing disease susceptibility for chronic myeloproliferative disease. (19258483)
2009
9
Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate. (18421200)
2008
10
Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation. (17972958)
2008
11
A novel ETV6-PDGFRB fusion transcript missed by standard screening in a patient with an imatinib responsive chronic myeloproliferative disease. (17508004)
2007
12
Improvement of fibrosis in a patient with chronic myeloproliferative disease. (17910624)
2007
13
Molecular diagnosis of chronic myeloproliferative diseases and myelodysplastic syndromes]. (18314608)
2007
14
Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation. (17376889)
2007
15
Serum levels, and bone marrow immunohistochemical expression of, vascular endothelial growth factor in patients with chronic myeloproliferative diseases. (17852434)
2007
16
Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis. (17707884)
2007
17
Donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) after cord blood transplantation in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. (17875537)
2007
18
Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation. (17449802)
2007
19
Hyperhomocysteinemia--one of the factors underlying thrombotic complications in patients with chronic myeloproliferative diseases]. (18220034)
2007
20
Diagnostic algorithm in chronic myeloproliferative diseases (CMPD)]. (17879017)
2007
21
Recent advances in the bcr-abl negative chronic myeloproliferative diseases. (17032464)
2006
22
Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? (17178662)
2006
23
Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases. (16445842)
2006
24
SDF1-3'A gene polymorphism is associated with chronic myeloproliferative disease and thrombotic events. (16306115)
2005
25
Localized cutaneous cryptococcosis in a patient with chronic myeloproliferative disease. (16334871)
2005
26
Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. (15618966)
2005
27
Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases. (16115126)
2005
28
Inv(1)(p22q25) in chronic myeloproliferative disease: constitutional or clonal defect? (15796968)
2005
29
A rapidly progressive chronic myeloproliferative disease with isolated trisomy 6. (15036897)
2004
30
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet- derived growth factor receptor beta. (12181402)
2002
31
The role of morphology, cytochemistry and immunohistochemistry in the diagnosis of chronic myeloproliferative diseases. (12430892)
2002
32
Angiogenesis in chronic myeloproliferative diseases. (11815715)
2001
33
Clonality analysis using X-chromosome inactivation at the human androgen receptor gene (Humara). Evaluation of large cohorts of patients with chronic myeloproliferative diseases, secondary neutrophilia, and reactive thrombocytosis. (10396290)
1999
34
N-RAS activation in the terminal stage of undifferentiated chronic myeloproliferative disease. (1391809)
1992
35
Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells. (1682923)
1991
36
Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease. (2397474)
1990
37
Functional and morphological studies of platelet reactivity with vessel wall subendothelium in chronic myeloproliferative disease. (6944099)
1981

Variations for Chronic Myeloproliferative Disease

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Expression for genes affiliated with Chronic Myeloproliferative Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Myeloproliferative Disease

Search GEO for disease gene expression data for Chronic Myeloproliferative Disease.

Pathways for genes affiliated with Chronic Myeloproliferative Disease

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Sources:
51PathCards, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 52PharmGKB, 62Tocris Bioscience, 31KEGG, 55R&D Systems, 5Cell Signaling Technology
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Pathways related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MPL, THPO
2
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.4PDGFRB, JAK2
3
Show member pathways
S1P2 pathway39
S1P4 pathway39
S1P5 pathway39
S1P1 pathway39
Sphingosine 1-phosphate (S1P) pathway39
9.4PDGFRB, JAK2
49.4JAK2, PDGFRB
5
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.3JAK2, B2M
6
Show member pathways
9.2FLT3, PDGFRB
79.1FLT3, THPO
8
Show member pathways
9.0JAK2, FLT3
9
Show member pathways
8.9THPO, JAK2, PDGFRB
10
Show member pathways
8.9THPO, JAK2, PDGFRB
11
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.9THPO, MPL, JAK2
12
Show member pathways
8.9JAK2, MPL, THPO
13
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
8.9JAK2, MPL, THPO
14
Show member pathways
8.7PDGFRB, FLT3, THPO
15
Show member pathways
8.7THPO, FLT3, PDGFRB
16
Show member pathways
8.7THPO, FLT3, PDGFRB
178.6FLT3, JAK2, PDGFRB
18
Show member pathways
8.2PDGFRB, JAK2, FLT3, MPL
19
Show member pathways
8.1THPO, FLT3, JAK2, PDGFRB
20
Show member pathways
8.1PDGFRB, JAK2, FLT3, THPO
21
Show member pathways
8.1PDGFRB, JAK2, FLT3, THPO
22
Show member pathways
7.6PDGFRB, JAK2, FLT3, MPL, THPO

Compounds for genes affiliated with Chronic Myeloproliferative Disease

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1megapoietin469.9MPL, THPO
2ifosfamide46 1210.7THPO, B2M
3pkc 412469.6PDGFRB, FLT3
4ag-1296469.6PDGFRB, FLT3
5phorbol 12,13-dibutyrate469.6JAK2, THPO
6ang ii469.6JAK2, PDGFRB
7su5416469.6FLT3, PDGFRB
8sunitinib46 52 1211.6PDGFRB, FLT3
9pixy321469.5THPO, FLT3
105fluorouracil469.5THPO, MPL, PDGFRB
11lestaurtinib46 6210.4JAK2, FLT3
12anagrelide46 1210.3JAK2, MPL, THPO
13sorafenib46 52 1211.3PDGFRB, FLT3
14matrigel469.3PDGFRB, JAK2, THPO
15methylcellulose469.3FLT3, THPO
16aspirin46 52 30 2512.2JAK2, MPL, THPO
17ly294002469.2THPO, JAK2, PDGFRB
18iron46 2510.2MPL, B2M, THPO
19wortmannin469.2THPO, JAK2, PDGFRB
20thromboxane46 2510.2THPO, MPL
21indomethacin46 30 62 1212.1THPO, B2M, JAK2
22butyrate469.1JAK2, B2M, THPO
23tgf beta1469.1PDGFRB, FLT3, THPO
24lysine469.1THPO, MPL, JAK2
25cisplatin46 52 62 1212.0PDGFRB, JAK2, B2M
26phosphotyrosine469.0PDGFRB, JAK2, FLT3
27h2o2468.9PDGFRB, JAK2, THPO
28agar468.9THPO, MPL, JAK2, PDGFRB
295-aza-2deoxycytidine468.9JAK2, FLT3, THPO
30phosphoinositide468.9PDGFRB, JAK2, FLT3
31genistein46 30 62 3 25 1213.8THPO, B2M, JAK2, PDGFRB
32lactate468.8FLT3, B2M, THPO
33estrogen468.8THPO, B2M, JAK2, PDGFRB
34glucose468.7THPO, B2M, JAK2, PDGFRB
35threonine468.6MPL, FLT3, JAK2, PDGFRB
36imatinib46 52 1210.5THPO, FLT3, JAK2, PDGFRB
37rapamycin468.5PDGFRB, JAK2, FLT3, THPO
38aspartate468.5B2M, FLT3, JAK2
39oligonucleotide468.5THPO, FLT3, JAK2, PDGFRB
40atp46 309.5THPO, FLT3, JAK2, PDGFRB
41thymidine46 259.4THPO, B2M, FLT3, JAK2
42alanine468.4THPO, B2M, MPL, JAK2, PDGFRB
43cysteine468.4THPO, B2M, MPL, JAK2, PDGFRB
44serine468.4PDGFRB, JAK2, MPL, B2M
45gp 130468.1PDGFRB, JAK2, FLT3, MPL, THPO
46phosphatidylinositol468.1PDGFRB, JAK2, FLT3, MPL, THPO
47adp46 30 2510.1THPO, MPL, FLT3, JAK2, PDGFRB
48tyrosine468.1THPO, MPL, FLT3, JAK2, PDGFRB
49retinoic acid46 259.0THPO, B2M, FLT3, JAK2, PDGFRB
50vegf467.6THPO, B2M, MPL, FLT3, JAK2, PDGFRB

GO Terms for genes affiliated with Chronic Myeloproliferative Disease

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17Gene Ontology
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Biological processes related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphoprotein phosphatase activityGO:0325169.7PDGFRB, JAK2
2platelet-derived growth factor receptor signaling pathwayGO:0480089.6JAK2, PDGFRB
3positive regulation of cell migrationGO:0303359.4PDGFRB, JAK2
4positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.4PDGFRB, FLT3
5positive regulation of MAP kinase activityGO:0434069.4PDGFRB, FLT3
6positive regulation of ERK1 and ERK2 cascadeGO:0703749.2PDGFRB, THPO
7interferon-gamma-mediated signaling pathwayGO:0603339.2JAK2, B2M
8positive regulation of phosphatidylinositol 3-kinase signalingGO:0140688.9PDGFRB, JAK2, FLT3
9blood coagulationGO:0075968.9THPO, MPL, JAK2
10peptidyl-tyrosine phosphorylationGO:0181088.9PDGFRB, JAK2, FLT3
11protein autophosphorylationGO:0467778.8FLT3, JAK2, PDGFRB
12cytokine-mediated signaling pathwayGO:0192218.7JAK2, FLT3, B2M
13positive regulation of cell proliferationGO:0082848.7PDGFRB, JAK2, FLT3

Molecular functions related to Chronic Myeloproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.4PDGFRB, JAK2
2cytokine receptor activityGO:0048968.9FLT3, MPL
3phosphatidylinositol 3-kinase bindingGO:0435488.5PDGFRB, JAK2, FLT3

Products for genes affiliated with Chronic Myeloproliferative Disease

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  • Antibodies
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  • Lysates
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Sources for Chronic Myeloproliferative Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet