Aliases & Classifications for Chronic Myocardial Ischemia

MalaCards integrated aliases for Chronic Myocardial Ischemia:

Name: Chronic Myocardial Ischemia 37 51 69

Summaries for Chronic Myocardial Ischemia

MalaCards based summary : Chronic Myocardial Ischemia is related to ischemia and angiodysplasia. An important gene associated with Chronic Myocardial Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Trimetazidine and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Chronic Myocardial Ischemia

Diseases related to Chronic Myocardial Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 ischemia 10.5
2 angiodysplasia 10.4 FGF2 VEGFA
3 radiation proctitis 10.4 FGF2 VEGFA
4 gastrointestinal neuroendocrine tumor 10.4 CHGA VEGFA
5 pancreatic serous cystadenoma 10.4 CHGA VEGFA
6 angiomatous meningioma 10.4 FGF2 VEGFA
7 dupuytren contracture 10.4 FGF2 VEGFA
8 carcinoid syndrome 10.3 CHGA VEGFA
9 lipodermatosclerosis 10.3 ANGPT1 VEGFA
10 wrinkles 10.3 HGF VEGFA
11 juvenile nasopharyngeal angiofibroma 10.3 FGF2 VEGFA
12 cecum adenocarcinoma 10.3 CHGA FGF2
13 vascular cancer 10.3 FGF2 VEGFA
14 hemifacial spasm 10.3 NOS3 VEGFA
15 bladder squamous cell carcinoma 10.3 FGF2 HGF
16 vitreous detachment 10.3 PLG VEGFA
17 chronic mountain sickness 10.3 NOS3 VEGFA
18 blood group, globoside system 10.3 PLG VEGFA
19 kuhnt-junius degeneration 10.3 PLG VEGFA
20 endophthalmitis 10.3 PLG VEGFA
21 nodular goiter 10.3 HGF VEGFA
22 retinal vascular occlusion 10.2 PLG VEGFA
23 anterior cranial fossa meningioma 10.2 CHGA PLG
24 epileptic encephalopathy, childhood-onset 10.2 ANGPT1 VEGFA
25 pericardial effusion 10.2 FGF2 VEGFA
26 connective tissue cancer 10.2 FGF2 VEGFA
27 breast carcinoma in situ 10.2 FGF2 VEGFA
28 acute mountain sickness 10.2 NOS3 VEGFA
29 hepatopulmonary syndrome 10.2 NOS3 VEGFA
30 gastric ulcer 10.1 FGF2 HGF
31 peripheral artery disease 10.1 NOS3 VEGFA
32 degeneration of macula and posterior pole 10.1 PLG VEGFA
33 pancreatic ductal carcinoma 10.1 TYMP VEGFA
34 microvascular complications of diabetes 1 10.1 FGF2 HGF VEGFA
35 hepatic vascular disease 10.1 NOS3 PLG
36 capillary hemangioma 10.0 TEK VEGFA
37 vitreous disease 10.0 FGF2 PLG VEGFA
38 vitreoretinopathy, neovascular inflammatory 10.0 FGF2 HGF
39 keratitis, hereditary 10.0 FGF2 VEGFA
40 endotheliitis 10.0
41 macular degeneration, age-related, 1 10.0 FGF2 PLG VEGFA
42 intramuscular hemangioma 10.0 ANGPT1 TEK
43 plague 10.0 PLG TYMP
44 cardiovascular organ benign neoplasm 10.0 FGF2 TEK
45 benign perivascular tumor 10.0 FGF2 TEK
46 placenta accreta 10.0 ANGPT1 TEK
47 adenosquamous pancreas carcinoma 9.9 ANGPT1 TEK
48 glomangioma 9.9 FGF2 TEK
49 arteries, anomalies of 9.9 NOS3 PLG VEGFA
50 hypercholesterolemia, autosomal dominant, 3 9.9

Comorbidity relations with Chronic Myocardial Ischemia via Phenotypic Disease Network (PDN): (show top 50) (show all 131)


Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Anthracosis
Anxiety Aortic Aneurysm
Aortic Atherosclerosis Aortic Valve Disease 1
Asbestosis Atrioventricular Block
Atrophic Gastritis Basilar Artery Insufficiency
Benign Essential Hypertension Bladder Cancer
Bronchitis Bronchopneumonia
Cardiac Arrest Cardiac Arrhythmia
Cardiogenic Shock Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Cholecystitis Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Pulmonary Heart Disease
Conjunctivitis Coronary Artery Aneurysm
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Dressler's Syndrome
Duodenitis Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder
Generalized Atherosclerosis Gout

Graphical network of the top 20 diseases related to Chronic Myocardial Ischemia:



Diseases related to Chronic Myocardial Ischemia

Symptoms & Phenotypes for Chronic Myocardial Ischemia

MGI Mouse Phenotypes related to Chronic Myocardial Ischemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 NOS3 ANGPT1 PLG CHGA TEK FGF2
2 homeostasis/metabolism MP:0005376 9.97 NOS3 ANGPT1 PLG CHGA TEK FGF2
3 growth/size/body region MP:0005378 9.95 VEGFA NOS3 ANGPT1 PLG CHGA TEK
4 mortality/aging MP:0010768 9.92 NOS3 ANGPT1 PLG CHGA TEK FGF2
5 nervous system MP:0003631 9.7 VEGFA NOS3 ANGPT1 PLG TEK TYMP
6 muscle MP:0005369 9.65 VEGFA NOS3 ANGPT1 TEK FGF2
7 renal/urinary system MP:0005367 9.35 VEGFA NOS3 ANGPT1 PLG CHGA
8 vision/eye MP:0005391 9.1 NOS3 ANGPT1 PLG TEK FGF2 VEGFA

Drugs & Therapeutics for Chronic Myocardial Ischemia

Drugs for Chronic Myocardial Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trimetazidine Approved, Investigational Phase 4 5011-34-7
2 Vasodilator Agents Phase 4
3
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
4
Fenofibrate Approved Phase 3 49562-28-9 3339
5 Antimetabolites Phase 3
6 Hypolipidemic Agents Phase 3
7 Lipid Regulating Agents Phase 3
8
Altretamine Approved Phase 2 645-05-6 2123
9 Pharmaceutical Solutions Phase 2,Phase 1
10 Anesthetics Phase 2
11 Adjuvants, Immunologic Phase 2
12
Zinc Approved, Investigational 7440-66-6 32051 23994
13 Angiogenesis Inducing Agents
14 Angiogenesis Inhibitors
15 Angiogenesis Modulating Agents
16 Angiostatins
17 Endostatins 71581480
18 Hormones

Interventional clinical trials:

(show all 37)

# Name Status NCT ID Phase Drugs
1 Effect of Metabolic Therapy in Patients With Chronic Ischemic Heart Disease Completed NCT00282360 Phase 4 Trimetazidine
2 Evaluation Rehabilitation on Glycometabolic State in Non-Diabetic Coronary Artery Disease (CAD) Patients Completed NCT00917930 Phase 4
3 Cell Therapy in Severe Chronic Ischemic Heart Disease Unknown status NCT01727063 Phase 2, Phase 3
4 Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina Completed NCT01508910 Phase 3
5 Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Mild or Moderate Renal Impairment Recruiting NCT03011450 Phase 3 K-877;Fenofibrate;Placebo (for K-877)
6 Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Normal Renal Function Recruiting NCT03001817 Phase 3 K-877;Fenofibrate;Placebo (for K-877);Placebo (for Fenofibrate)
7 Cell Therapy in Chronic Ischemic Heart Disease Terminated NCT00362388 Phase 3
8 Cell Therapy in Patients With Chronic Ischemic Heart Disease Undergoing Cardiac Surgery Unknown status NCT01267331 Phase 1, Phase 2
9 MesenchYmal STROMAL CELL Therapy in Patients With Chronic Myocardial Ischemia (MyStromalCell Trial) Completed NCT01449032 Phase 2
10 Mesenchymal Stem Cells and Myocardial Ischemia Completed NCT01076920 Phase 1, Phase 2
11 Safety & Efficacy of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia (ATHENA II) Completed NCT02052427 Phase 2
12 Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia Completed NCT01556022 Phase 2
13 Intracoronary Infusion of Bone Marrow Mononuclear Cells in Patients With Previous Myocardial Infarction. Completed NCT01454323 Phase 2
14 ACT34-CMI -- Adult Autologous CD34+ Stem Cells Completed NCT00300053 Phase 2
15 Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium Completed NCT00326989 Phase 1, Phase 2
16 Stem Cell Mobilization to Treat Chest Pain and Shortness of Breath in Patients With Coronary Artery Disease Completed NCT00043628 Phase 2
17 Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study) Completed NCT00824005 Phase 2
18 By Pass Surgery With Stem Cell Therapy in Chronic Ischemic Cardiopathy Completed NCT00690209 Phase 2
19 Stem Cell Therapy for Vasculogenesis in Patients With Severe Myocardial Ischemia Completed NCT00260338 Phase 1, Phase 2
20 Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy Completed NCT00629018 Phase 2 Bone Marrow Stimulation
21 Administration of Mesenchymal Stem Cells in Patients With Chronic Ischemic Cardiomyopathy (MESAMI2) Recruiting NCT02462330 Phase 2 Autologous MSC from bone marrow;Placebo comparator
22 Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy Recruiting NCT02439541 Phase 1, Phase 2
23 Human Umbilical Cord Stroma MSC in Myocardial Infarction Recruiting NCT02323477 Phase 1, Phase 2
24 Stem Cell Study for Patients With Heart Disease Terminated NCT00221182 Phase 1, Phase 2
25 METHOD - Bone Marrow Derived Mononuclear Cells in Chronic Ischemic Disease Terminated NCT01666132 Phase 1, Phase 2
26 Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions Completed NCT00365326 Phase 1
27 Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease Recruiting NCT03043742 Phase 1 Bone Marrow Derived Autologous CD133+ Selected Cell Product
28 Phase I Trial of Endocavitary Injection of Bone Marrow Derived CD133+ Cells in Ischemic Refractory Cardiomyopathy (RECARDIO Trial) Recruiting NCT02059681 Phase 1
29 Bone Marrow-derived Mesenchymal Stem Cells (MSC) Administration in Weaning From Left Ventricular Assist Device Withdrawn NCT02460770 Phase 1 Autologous mesenchymal stem cells
30 Bone Marrow Derived Mononuclear Cells for Ischemic Cardiomyopathy Unknown status NCT01144221
31 ACT34-CMI -- Adult Autologous CD34+ Stem Cells (Follow-Up Study) Completed NCT00545610
32 Quality of Life in Patients With Chronic Ischemic Heart Disease Completed NCT00005671
33 Increasing the Efficiency of Depression-screening Using Patient-targeted Feedback Completed NCT01879111
34 Heavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD) Completed NCT02159235
35 Sex and Gender Differences in Ischemic Heart Disease - Endocrine Vascular Disease Approach Recruiting NCT02737982
36 Hyperbaric Oxygen Therapy in Patients With Chronic Stable Ischemic Heart Disease: An Option for Therapeutic Angiogenesis? Recruiting NCT02760394
37 The Microbiome as a Target for Precision Medicine in Atherosclerosis Not yet recruiting NCT03434483

Search NIH Clinical Center for Chronic Myocardial Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Myocardial Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myocardial Ischemia:
CD34+ stem cells for treatment of congestive heart failure
Embryonic/Adult Cultured Cells Related to Chronic Myocardial Ischemia:
Bone marrow-derived hematopoietic stem cells (family) PMIDs: 22163120

Genetic Tests for Chronic Myocardial Ischemia

Anatomical Context for Chronic Myocardial Ischemia

MalaCards organs/tissues related to Chronic Myocardial Ischemia:

38
Heart, Bone, Bone Marrow, Endothelial

Publications for Chronic Myocardial Ischemia

Articles related to Chronic Myocardial Ischemia:

(show all 43)
# Title Authors Year
1
Safety and efficacy of percutaneous intramyocardial bone marrow cell injection for chronic myocardial ischemia: Long-term results. ( 28752630 )
2017
2
Comparison of the Therapeutic Effects of Acupuncture at PC6 and ST36 for Chronic Myocardial Ischemia. ( 28900462 )
2017
3
Chronic Myocardial Ischemia Leads to Loss of Maximal Oxygen Consumption and Complex I Dysfunction. ( 28577850 )
2017
4
Human Umbilical Cord-Derived Mesenchymal Stromal Cells Improve Left Ventricular Function, Perfusion, and Remodeling in a Porcine Model of Chronic Myocardial Ischemia. ( 27334487 )
2016
5
Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia. ( 28024857 )
2016
6
The Athena Trials: Autologous Adipose-Derived Regenerative Cells (ADRCs) for Refractory Chronic Myocardial Ischemia with Left Ventricular Dysfunction. ( 27148802 )
2016
7
Vitexin exerts cardioprotective effect on chronic myocardial ischemia/reperfusion injury in rats via inhibiting myocardial apoptosis and lipid peroxidation. ( 27648122 )
2016
8
Plasma Catestatin: A Useful Biomarker for Coronary Collateral Development with Chronic Myocardial Ischemia. ( 27304618 )
2016
9
Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia. ( 27818233 )
2016
10
Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: Results of the MESAMI 1 pilot trial. ( 26901787 )
2016
11
Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia. ( 26478238 )
2015
12
Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia. ( 25991048 )
2015
13
Placental growth factor 2 - A potential therapeutic strategy for chronic myocardial ischemia. ( 26569359 )
2015
14
Predictors of response to intramyocardial bone marrow cell treatment in patients with refractory angina and chronic myocardial ischemia. ( 25023791 )
2014
15
Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia. ( 25111309 )
2014
16
Induced pluripotent stem cell transplantation in the treatment of porcine chronic myocardial ischemia. ( 25443017 )
2014
17
Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia. ( 24481723 )
2014
18
Early use of granulocyte colony stimulating factor improves survival in a rabbit model of chronic myocardial ischemia. ( 23085036 )
2013
19
Long term effects of intramyocardial bone marrow cell injection on anginal symptoms and quality of life in patients with chronic myocardial ischemia. ( 23628299 )
2013
20
Placental growth factor increases regional myocardial blood flow and contractile function in chronic myocardial ischemia. ( 23316060 )
2013
21
Energy metabolism disorder and myocardial injury in chronic myocardial ischemia with Qi deficiency and blood stasis syndrome based on 2-DE proteomics. ( 23212566 )
2013
22
Local infiltration of neuropeptide Y as a potential therapeutic agent against apoptosis and fibrosis in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 24051270 )
2013
23
The bottleneck stent model for chronic myocardial ischemia and heart failure in pigs. ( 23997096 )
2013
24
Microvascular Notch Signaling Is Upregulated in Response to Vascular Endothelial Growth Factor and Chronic Myocardial Ischemia. ( 24366099 )
2013
25
Quantitative T 2* assessment of acute and chronic myocardial ischemia/reperfusion injury in mice. ( 22327962 )
2012
26
Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design. ( 22594332 )
2012
27
Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia. ( 24693195 )
2012
28
Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 22982235 )
2012
29
Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparison. ( 23137509 )
2012
30
Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia. ( 21305250 )
2011
31
Early detection of chronic myocardial ischemia in a patient implanted with an ICD capable of intracardiac electrogram monitoring. ( 22147404 )
2011
32
Bone marrow cell injection for chronic myocardial ischemia: the past and the future. ( 21213093 )
2011
33
Intramyocardial bone marrow-derived mononuclear cell injection for chronic myocardial ischemia: the effect on diastolic function. ( 21209073 )
2011
34
Human hepatocyte growth factor (VM202) gene therapy via transendocardial injection in a pig model of chronic myocardial ischemia. ( 21703533 )
2011
35
Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes. ( 17846323 )
2007
36
Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model. ( 16547766 )
2006
37
Gene therapy for chronic myocardial ischemia using platelet-derived endothelial cell growth factor in dogs. ( 15374822 )
2005
38
Cardiomyocyte hyperplasia after plasmid-mediated vascular endothelial growth factor gene transfer in pigs with chronic myocardial ischemia. ( 14978775 )
2004
39
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT). ( 12742981 )
2003
40
Gene therapy in cardiac surgery: intramyocardial injection of naked plasmid DNA for chronic myocardial ischemia. ( 14583313 )
2003
41
Comparison of protein with DNA therapy for chronic myocardial ischemia using fibroblast growth factor-2. ( 12467820 )
2002
42
Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. ( 10640320 )
2000
43
Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia. ( 10961959 )
2000

Variations for Chronic Myocardial Ischemia

Expression for Chronic Myocardial Ischemia

Search GEO for disease gene expression data for Chronic Myocardial Ischemia.

Pathways for Chronic Myocardial Ischemia

Pathways related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 ANGPT1 CHGA FGF2 HGF NOS3 TEK
2
Show member pathways
13.57 ANGPT1 FGF2 HGF TEK TYMP VEGFA
3
Show member pathways
13.46 FGF2 HGF NOS3 TEK TYMP VEGFA
4
Show member pathways
13.27 ANGPT1 FGF2 HGF TEK VEGFA
5
Show member pathways
13.27 ANGPT1 FGF2 HGF TEK TYMP VEGFA
6
Show member pathways
13.15 ANGPT1 FGF2 HGF NOS3 TEK TYMP
7
Show member pathways
13.11 ANGPT1 FGF2 HGF TEK VEGFA
8
Show member pathways
13.07 ANGPT1 HGF NOS3 PLG TEK VEGFA
9
Show member pathways
13.04 ANGPT1 FGF2 HGF TEK TYMP
10
Show member pathways
13.02 FGF2 HGF NOS3 TEK TYMP VEGFA
11 12.46 ANGPT1 FGF2 HGF TEK VEGFA
12
Show member pathways
12.46 ANGPT1 FGF2 HGF NOS3 TEK VEGFA
13
Show member pathways
12.41 ANGPT1 FGF2 HGF TEK VEGFA
14
Show member pathways
12.25 ANGPT1 FGF2 NOS3 PLG TEK
15 12.09 FGF2 HGF VEGFA
16
Show member pathways
12.01 FGF2 NOS3 VEGFA
17 11.87 FGF2 HGF VEGFA
18 11.78 FGF2 HGF VEGFA
19 11.67 ANGPT1 TEK VEGFA
20 11.56 ANGPT1 NOS3 TEK VEGFA
21 11.32 FGF2 PLG VEGFA
22 11.31 FGF2 VEGFA
23 11.3 FGF2 HGF NOS3 TEK TYMP
24 11.29 FGF2 HGF VEGFA
25
Show member pathways
11.27 HGF VEGFA
26 11.27 FGF2 VEGFA
27 11.21 ANGPT1 TEK
28 11.2 ANGPT1 VEGFA
29 11.1 FGF2 PLG
30 11.01 FGF2 VEGFA
31 10.78 ANGPT1 FGF2 HGF TEK TYMP
32 10.4 ANGPT1 FGF2 NOS3 TEK VEGFA

GO Terms for Chronic Myocardial Ischemia

Cellular components related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 ANGPT1 CHGA FGF2 HGF PLG VEGFA
2 extracellular region GO:0005576 9.5 ANGPT1 CHGA FGF2 HGF PLG TEK
3 platelet alpha granule lumen GO:0031093 8.8 HGF PLG VEGFA

Biological processes related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.86 ANGPT1 HGF TEK VEGFA
2 regulation of receptor activity GO:0010469 9.85 FGF2 HGF TYMP VEGFA
3 in utero embryonic development GO:0001701 9.78 ANGPT1 NOS3 VEGFA
4 MAPK cascade GO:0000165 9.78 ANGPT1 FGF2 HGF TEK
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 ANGPT1 FGF2 TEK
6 peptidyl-tyrosine phosphorylation GO:0018108 9.74 FGF2 HGF TEK
7 platelet degranulation GO:0002576 9.7 HGF PLG VEGFA
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 ANGPT1 HGF VEGFA
9 positive regulation of endothelial cell proliferation GO:0001938 9.67 FGF2 TEK VEGFA
10 positive regulation of cell adhesion GO:0045785 9.63 ANGPT1 VEGFA
11 positive regulation of cell division GO:0051781 9.63 FGF2 VEGFA
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 ANGPT1 HGF TEK
13 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.62 HGF NOS3
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.62 ANGPT1 TEK
15 positive regulation of protein kinase B signaling GO:0051897 9.62 ANGPT1 FGF2 HGF TEK
16 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.61 FGF2 TEK
17 sprouting angiogenesis GO:0002040 9.59 ANGPT1 TEK
18 positive regulation of focal adhesion assembly GO:0051894 9.58 TEK VEGFA
19 positive regulation of receptor internalization GO:0002092 9.58 ANGPT1 VEGFA
20 positive regulation of endothelial cell migration GO:0010595 9.58 ANGPT1 TEK VEGFA
21 positive chemotaxis GO:0050918 9.56 ANGPT1 FGF2 HGF VEGFA
22 positive regulation of angiogenesis GO:0045766 9.55 FGF2 HGF NOS3 TEK VEGFA
23 cell migration involved in sprouting angiogenesis GO:0002042 9.54 FGF2 VEGFA
24 glomerulus vasculature development GO:0072012 9.43 ANGPT1 TEK
25 Tie signaling pathway GO:0048014 9.37 ANGPT1 TEK
26 positive regulation of blood vessel endothelial cell migration GO:0043536 9.26 ANGPT1 FGF2 NOS3 VEGFA
27 angiogenesis GO:0001525 9.1 ANGPT1 FGF2 NOS3 TEK TYMP VEGFA

Molecular functions related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 FGF2 HGF TYMP VEGFA
2 protein tyrosine kinase activity GO:0004713 9.43 FGF2 HGF TEK
3 chemoattractant activity GO:0042056 9.13 FGF2 HGF VEGFA
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 ANGPT1 FGF2 HGF TEK

Sources for Chronic Myocardial Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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