Aliases & Classifications for Chronic Myocardial Ischemia

MalaCards integrated aliases for Chronic Myocardial Ischemia:

Name: Chronic Myocardial Ischemia 38 52 69

Summaries for Chronic Myocardial Ischemia

MalaCards based summary : Chronic Myocardial Ischemia is related to tooth erosion and aicardi-goutieres syndrome. An important gene associated with Chronic Myocardial Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Chronic Myocardial Ischemia

Diseases related to Chronic Myocardial Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Related Disease Score Top Affiliating Genes
1 tooth erosion 10.6 FGF2 VEGFA
2 aicardi-goutieres syndrome 10.6 CHGA VEGFA
3 diffuse lipomatosis 10.6 CHGA VEGFA
4 segmental odontomaxillary dysplasia 10.6 FGF2 VEGFA
5 posterior foramen magnum meningioma 10.6 FGF2 VEGFA
6 ohdo syndrome, maat-kievit-brunner type 10.6 FGF2 VEGFA
7 tumor of exocrine pancreas 10.6 FGF2 VEGFA
8 carcinoma of unknown primary site, childhood 10.5 CHGA VEGFA
9 lipoic acid synthetase deficiency 10.5 ANGPT1 VEGFA
10 angiosarcoma 10.5 HGF VEGFA
11 wissler's syndrome 10.5 CHGA FGF2
12 large intestine adenoma 10.5 FGF2 VEGFA
13 tetrahydrobiopterin-responsive hyperphenylalaninemia/phenylketonuria 10.5 FGF2 VEGFA
14 mitral valve stenosis 10.5 FGF2 VEGFA
15 hypertonia 10.5 NOS3 VEGFA
16 ischemia 10.5
17 esophagus squamous cell carcinoma 10.4 FGF2 HGF
18 lethal congenital contractural syndrome 2 10.4 NOS3 VEGFA
19 iliac vein thrombophlebitis 10.4 PLG VEGFA
20 conjugate gaze palsy 10.4 PLG VEGFA
21 perineurioma 10.4 PLG VEGFA
22 cryptosporidiosis 10.4 PLG VEGFA
23 central nervous system germ cell tumor 10.4 CHGA PLG
24 urinary bladder posterior wall cancer 10.4 FGF2 VEGFA
25 diabetes mellitus, insulin-dependent, 3 10.4 ANGPT1 VEGFA
26 gestational choriocarcinoma 10.3 FGF2 VEGFA
27 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.3 NOS3 VEGFA
28 placental choriocarcinoma 10.3 PLG VEGFA
29 tibialis tendinitis 10.3 FGF2 HGF
30 esophageal leukoplakia 10.3 NOS3 VEGFA
31 choriocarcinoma 10.2 TYMP VEGFA
32 neuropathy, hereditary sensory and autonomic, type vi 10.2 FGF2 HGF VEGFA
33 capillary hemangioma 10.2 NOS3 PLG
34 purulent endophthalmitis 10.1 FGF2 PLG VEGFA
35 focal dystonia 10.1 FGF2 NOS3 VEGFA
36 vesiculobullous skin disease 10.1 TEK VEGFA
37 exudative vitreoretinopathy 1 10.1 FGF2 HGF
38 cutaneous mucoepidermoid carcinoma 10.1 ANGPT1 TEK
39 thymus lymphoma 10.1 FGF2 HGF
40 turner syndrome 10.1 PLG TYMP
41 bone benign neoplasm 10.0 FGF2 TEK
42 hilar cholangiocellular carcinoma 10.0 FGF2 TEK
43 testicular leydig cell tumor 10.0 ANGPT1 TEK
44 cervical cancer, somatic 10.0 FGF2 TYMP VEGFA
45 macular degeneration, age-related, 1 10.0 FGF2 PLG VEGFA
46 hyperpituitarism 10.0 FGF2 TEK
47 endotheliitis 9.9
48 peripheral artery disease 9.9 NOS3 PLG VEGFA
49 ovarian insufficiency, familial 9.9 PLG VEGFA
50 pituitary infarct 9.8 TEK VEGFA

Comorbidity relations with Chronic Myocardial Ischemia via Phenotypic Disease Network (PDN): (show top 50) (show all 128)


Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Anthracosis Anxiety Disorder
Aortic Aneurysm Aortic Atherosclerosis
Asbestosis Atrioventricular Block
Atrophic Gastritis Basilar Artery Insufficiency
Benign Essential Hypertension Benign Paroxysmal Positional Nystagmus
Bronchitis Bronchopneumonia
Cardiac Arrest Cardiogenic Shock
Cardiomyopathy, Familial Hypertrophic Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Cholecystitis Chronic Kidney Failure
Chronic Pulmonary Heart Disease Conjunctivitis
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Dressler's Syndrome
Duodenitis Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder
Generalized Atherosclerosis Gout
Heart Conduction Disease Heart Disease
Hepatitis Hyperlipidemia, Familial Combined

Graphical network of the top 20 diseases related to Chronic Myocardial Ischemia:



Diseases related to Chronic Myocardial Ischemia

Symptoms & Phenotypes for Chronic Myocardial Ischemia

MGI Mouse Phenotypes related to Chronic Myocardial Ischemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ANGPT1 CHGA FGF2 HGF NOS3 PLG
2 homeostasis/metabolism MP:0005376 9.97 ANGPT1 CHGA FGF2 NOS3 PLG TEK
3 growth/size/body region MP:0005378 9.95 NOS3 PLG TEK VEGFA ANGPT1 CHGA
4 mortality/aging MP:0010768 9.92 ANGPT1 CHGA FGF2 HGF NOS3 PLG
5 nervous system MP:0003631 9.7 ANGPT1 FGF2 NOS3 PLG TEK TYMP
6 muscle MP:0005369 9.65 ANGPT1 FGF2 NOS3 TEK VEGFA
7 renal/urinary system MP:0005367 9.35 ANGPT1 CHGA NOS3 PLG VEGFA
8 vision/eye MP:0005391 9.1 ANGPT1 FGF2 NOS3 PLG TEK VEGFA

Drugs & Therapeutics for Chronic Myocardial Ischemia

Drugs for Chronic Myocardial Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 363)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4,Phase 3 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4,Phase 3 53123-88-9 5284616 6436030 46835353
4
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
5
Tirofiban Approved Phase 4 144494-65-5 60947
6
Ticagrelor Approved Phase 4,Phase 2,Phase 1 274693-27-5 9871419
7
Ranolazine Approved, Investigational Phase 4,Phase 2,Phase 3 142387-99-3, 95635-55-5 56959
8
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
9
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
10
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
11
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
12
Metformin Approved Phase 4,Phase 2 657-24-9 14219 4091
13
Atenolol Approved Phase 4 29122-68-7 2249
14
Nicorandil Approved Phase 4 65141-46-0 47528
15
Citalopram Approved Phase 4 59729-33-8 2771
16
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
17
Simvastatin Approved Phase 4 79902-63-9 54454
18
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
19
Trimetazidine Approved Phase 4 5011-34-7
20
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
21
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
22
Febuxostat Approved Phase 4 144060-53-7 134018
23
Adenosine Approved, Investigational Phase 4,Phase 2 58-61-7 60961
24
Regadenoson Approved Phase 4 313348-27-5 219024
25
Ezetimibe Approved Phase 4 163222-33-1 150311
26
Cilostazol Approved Phase 4 73963-72-1 2754
27
Nifedipine Approved Phase 4 21829-25-4 4485
28
Dalteparin Approved Phase 4 9005-49-6
29
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
30
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
31
Allopurinol Approved Phase 4 315-30-0 2094
32
Morphine Approved, Investigational Phase 4 57-27-2 5288826
33
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
34
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
35 Magnesium citrate Approved Phase 4
36
Magnesium oxide Approved Phase 4 1309-48-4 14792
37
Dobutamine Approved Phase 4 34368-04-2 36811
38
Diltiazem Approved Phase 4,Phase 1 42399-41-7 39186
39
Verapamil Approved Phase 4,Phase 2 52-53-9 2520
40
Rivaroxaban Approved Phase 4 366789-02-8
41
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
42
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
43
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
44
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
45
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
46
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
47
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
48
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
49
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037

Interventional clinical trials:

(show top 50) (show all 470)

id Name Status NCT ID Phase Drugs
1 A Trial to Evaluate Efficacy of Heart-protecting Musk Pill Unknown status NCT01897805 Phase 4 Heart-protecting Musk Pill;Placebo
2 GISSOC II: Sirolimus Eluting Stent Versus Bare Metal Stent in Chronic Total Coronary Occlusions Unknown status NCT00220558 Phase 4
3 Impact of Intravascular Ultrasound(IVUS)-Guided Chronic Total Occlusion Intervention With Drug-eluting Stents Unknown status NCT01563952 Phase 4
4 Relationship Between Initial Plaque Characteristics and Stent Surface Coverage Patterns Unknown status NCT01024179 Phase 4
5 Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
6 Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease Unknown status NCT02294994 Phase 4 tirofiban
7 Potential Impact of Cigarette Smoking on Platelet Reactivity in Patients on Dual Antiplatelet Therapy With P2Y12 Inhibitors Unknown status NCT02026713 Phase 4
8 Ranolazine for Improving Symptoms of Palpitations Unknown status NCT01495520 Phase 4 Ranolazine;Placebo
9 Role of CT Scan for the Successful Recanalization of Chronic Total Occlusion; a Randomized Comparison Between 3D CT-guided PCI vs. Conventional Treatment (CT-CTO Trial) Unknown status NCT02037698 Phase 4
10 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
11 Safety of Amiodarone and Ranolazine Together in Patients With Angina Unknown status NCT01558830 Phase 4 ranolazine;placebo
12 Randomized Trial of Creatine-kinase Leak After Rosuvastatin At the Time of Percutaneous Coronary Intervention Unknown status NCT01968577 Phase 4 Rosuvastatin
13 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
14 Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel Unknown status NCT01643031 Phase 4 Ticagrelor;Continued clopidogrel
15 PCOS, Therapy and Markers of Cardiovascular Risk Unknown status NCT01798875 Phase 4 oral metformin;oral contraceptive
16 Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina. Unknown status NCT01397994 Phase 4 Nicorandil;Atenolol
17 Clopidogrel Reloading in Patients With NSTEACS Undergoing Percutaneous Coronary Intervention on Chronic Clopidogrel Therapy Unknown status NCT01572129 Phase 4 Clopidogrel;Placebo
18 Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD) Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
19 Effect of Metabolic Therapy in Patients With Chronic Ischemic Heart Disease Completed NCT00282360 Phase 4 Trimetazidine
20 Evaluation Rehabilitation on Glycometabolic State in Non-Diabetic Coronary Artery Disease (CAD) Patients Completed NCT00917930 Phase 4
21 Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina Completed NCT01425359 Phase 4 Ranolazine;Ranolazine placebo
22 Amlodipine vs Nitrates Study in Patients With Chronic Stable Angina Completed NCT00143195 Phase 4 Amlodipine;iso- 5 - mononitrate
23 Prasugrel Re-load Strategies Completed NCT01201772 Phase 4 Prasugrel
24 The Influence of Febuxostat on Coronary Artery Endothelial Dysfunction in Participants With Chronic Stable Angina Completed NCT01763996 Phase 4 Febuxostat;Febuxostat placebo
25 A Study of the Safety and Tolerance of Regadenoson in Subjects With Asthma or Chronic Obstructive Pulmonary Disease Completed NCT00862641 Phase 4 Regadenoson;Placebo
26 The XLIMUS-DES in Very Complex Lesions Completed NCT02360020 Phase 4
27 Ticagrelor China Pharmacokinetic/Pharmacodynamic Study Completed NCT02064985 Phase 4 Inhibition of Platelet Aggregation by "Brilinta"(Ticagrelor)
28 Study of Heart and Renal Protection Completed NCT00125593 Phase 4 Simvastatin 20 mg;Ezetimibe 10mg;Placebo
29 Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion: the "CrossBoss First" Trial Completed NCT02510547 Phase 4
30 Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Chronic Kidney Disease Completed NCT01328470 Phase 4 Clopidogrel, cilostazol
31 Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons Completed NCT00481351 Phase 4 Simvastatin 20mg plus ezetimibe 10mg;ezetimibe;simvastatin 20mg;Simvastatin 80mg
32 Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery Completed NCT00244530 Phase 4 Nifedipine
33 Effects of Low Molecular Weight Heparin Versus Dabigatran on Platelet Aggregation in Patients With Stable Coronary Artery Disease Completed NCT02389582 Phase 4 Dabigatran;Enoxaparin
34 Antithrombotic Regimens and Outcome Completed NCT00448461 Phase 4 heparin;bivalirudin
35 Capturing Outcomes of Clinical Activities Performed by a Rounding Pharmacist Practising in a Team Environment Completed NCT00351676 Phase 4 Optimizing therapeutic treatments
36 Clinical Impact of the Withdrawal of Nitrate in Patients With Stable Angina Completed NCT01769079 Phase 4 Nitrate;Placebo
37 Contrast-medium Induced Nephrotoxicity in Patients Undergoing Coronary Angiography - Iodixanol Versus Iopromide Completed NCT00823628 Phase 4 contrast agent (iopromide);contrast agent (iodixanol)
38 Iodixanol vs. Iomeprol to Prevent Contrast-Induced Nephropathy After Coronary Intervention (CONTRAST) Completed NCT00390585 Phase 4 Iodixanol 320;Iomeprol 350
39 Study of the Effect of Alendronate on Vascular Calcification and Arterial Stiffness in Chronic Kidney Disease Completed NCT00395382 Phase 4 Alendronate;Placebo
40 A Study of the Safety and Tolerance of Regadenoson in Subjects With Renal Impairment Completed NCT00863707 Phase 4 Regadenoson;Placebo
41 APEX Study: Effects of Allopurinol on Coronary and Peripheral Endothelial Function in Patients With Cardiac Syndrome X Completed NCT00512057 Phase 4 allopurinol;placebo
42 Guidewire for Chronic Total Occlusion Completed NCT00987610 Phase 4
43 AngiographiC Evaluation of the Everolimus-Eluting Stent in Chronic Total Occlusions - the ACE-CTO Study Completed NCT01012869 Phase 4
44 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4 cinacalcet
45 Oral Oxycodone After Major Cardiac Surgery Completed NCT01816581 Phase 4 Targin;Oxynorm;Morphine
46 The Absorption of Magnesium Oxide Compared to Citrate in Healthy Subjects Completed NCT00994006 Phase 4
47 A Randomized, Pharmacodynamic Comparison of Low Dose Ticagrelor to Clopidogrel in Patients With Prior Myocardial Infarction Completed NCT02663713 Phase 4 Ticagrelor;Clopidogrel
48 SMS: Substrate Modification Study in Patients Getting an Implantable Cardioverter Defibrillator (ICD) Completed NCT00170287 Phase 4
49 Stress Cardiac MRI for Evaluation of Nonspecific Allograft Dysfunction Completed NCT02597543 Phase 4 Regadenoson;Gadolinium
50 An Open-label, Multi-center Study Evaluating the Validity, Reliability, and Responsiveness of a New Female-specific Angina Questionnaire in Women With Chronic Angina Treated With Ranolazine Extended-release Tablets (CVT 3041) Completed NCT00644332 Phase 4 Ranolazine

Search NIH Clinical Center for Chronic Myocardial Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Myocardial Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myocardial Ischemia:
CD34+ stem cells for treatment of congestive heart failure
Embryonic/Adult Cultured Cells Related to Chronic Myocardial Ischemia:
Bone marrow-derived hematopoietic stem cells (family) PMIDs: 22163120

Genetic Tests for Chronic Myocardial Ischemia

Anatomical Context for Chronic Myocardial Ischemia

MalaCards organs/tissues related to Chronic Myocardial Ischemia:

39
Heart, Kidney, Bone, Endothelial, Bone Marrow, Testes, Lung

Publications for Chronic Myocardial Ischemia

Articles related to Chronic Myocardial Ischemia:

(show all 43)
id Title Authors Year
1
Chronic Myocardial Ischemia Leads to Loss of Maximal Oxygen Consumption and Complex I Dysfunction. ( 28577850 )
2017
2
Safety and efficacy of percutaneous intramyocardial bone marrow cell injection for chronic myocardial ischemia: Long-term results. ( 28752630 )
2017
3
Comparison of the Therapeutic Effects of Acupuncture at PC6 and ST36 for Chronic Myocardial Ischemia. ( 28900462 )
2017
4
Plasma Catestatin: A Useful Biomarker for Coronary Collateral Development with Chronic Myocardial Ischemia. ( 27304618 )
2016
5
Vitexin exerts cardioprotective effect on chronic myocardial ischemia/reperfusion injury in rats via inhibiting myocardial apoptosis and lipid peroxidation. ( 27648122 )
2016
6
The Athena Trials: Autologous Adipose-Derived Regenerative Cells (ADRCs) for Refractory Chronic Myocardial Ischemia with Left Ventricular Dysfunction. ( 27148802 )
2016
7
Human Umbilical Cord-Derived Mesenchymal Stromal Cells Improve Left Ventricular Function, Perfusion, and Remodeling in a Porcine Model of Chronic Myocardial Ischemia. ( 27334487 )
2016
8
Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia. ( 28024857 )
2016
9
Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: Results of the MESAMI 1 pilot trial. ( 26901787 )
2016
10
Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia. ( 27818233 )
2016
11
Placental growth factor 2 - A potential therapeutic strategy for chronic myocardial ischemia. ( 26569359 )
2015
12
Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia. ( 26478238 )
2015
13
Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia. ( 25991048 )
2015
14
Induced pluripotent stem cell transplantation in the treatment of porcine chronic myocardial ischemia. ( 25443017 )
2014
15
Predictors of response to intramyocardial bone marrow cell treatment in patients with refractory angina and chronic myocardial ischemia. ( 25023791 )
2014
16
Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia. ( 25111309 )
2014
17
Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia. ( 24481723 )
2014
18
Long term effects of intramyocardial bone marrow cell injection on anginal symptoms and quality of life in patients with chronic myocardial ischemia. ( 23628299 )
2013
19
The bottleneck stent model for chronic myocardial ischemia and heart failure in pigs. ( 23997096 )
2013
20
Placental growth factor increases regional myocardial blood flow and contractile function in chronic myocardial ischemia. ( 23316060 )
2013
21
Early use of granulocyte colony stimulating factor improves survival in a rabbit model of chronic myocardial ischemia. ( 23085036 )
2013
22
Microvascular Notch Signaling Is Upregulated in Response to Vascular Endothelial Growth Factor and Chronic Myocardial Ischemia. ( 24366099 )
2013
23
Local infiltration of neuropeptide Y as a potential therapeutic agent against apoptosis and fibrosis in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 24051270 )
2013
24
Energy metabolism disorder and myocardial injury in chronic myocardial ischemia with Qi deficiency and blood stasis syndrome based on 2-DE proteomics. ( 23212566 )
2013
25
Quantitative T 2* assessment of acute and chronic myocardial ischemia/reperfusion injury in mice. ( 22327962 )
2012
26
Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 22982235 )
2012
27
Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparison. ( 23137509 )
2012
28
Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design. ( 22594332 )
2012
29
Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia. ( 24693195 )
2012
30
Intramyocardial bone marrow-derived mononuclear cell injection for chronic myocardial ischemia: the effect on diastolic function. ( 21209073 )
2011
31
Bone marrow cell injection for chronic myocardial ischemia: the past and the future. ( 21213093 )
2011
32
Early detection of chronic myocardial ischemia in a patient implanted with an ICD capable of intracardiac electrogram monitoring. ( 22147404 )
2011
33
Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia. ( 21305250 )
2011
34
Human hepatocyte growth factor (VM202) gene therapy via transendocardial injection in a pig model of chronic myocardial ischemia. ( 21703533 )
2011
35
Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes. ( 17846323 )
2007
36
Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model. ( 16547766 )
2006
37
Gene therapy for chronic myocardial ischemia using platelet-derived endothelial cell growth factor in dogs. ( 15374822 )
2005
38
Cardiomyocyte hyperplasia after plasmid-mediated vascular endothelial growth factor gene transfer in pigs with chronic myocardial ischemia. ( 14978775 )
2004
39
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT). ( 12742981 )
2003
40
Gene therapy in cardiac surgery: intramyocardial injection of naked plasmid DNA for chronic myocardial ischemia. ( 14583313 )
2003
41
Comparison of protein with DNA therapy for chronic myocardial ischemia using fibroblast growth factor-2. ( 12467820 )
2002
42
Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. ( 10640320 )
2000
43
Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia. ( 10961959 )
2000

Variations for Chronic Myocardial Ischemia

Expression for Chronic Myocardial Ischemia

Search GEO for disease gene expression data for Chronic Myocardial Ischemia.

Pathways for Chronic Myocardial Ischemia

Pathways related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 ANGPT1 CHGA FGF2 HGF NOS3 TEK
2
Show member pathways
13.45 FGF2 HGF NOS3 TEK TYMP VEGFA
3
Show member pathways
13.25 ANGPT1 FGF2 HGF TEK VEGFA
4
Show member pathways
13.25 ANGPT1 FGF2 HGF TEK TYMP VEGFA
5
Show member pathways
13.12 ANGPT1 FGF2 HGF NOS3 TEK TYMP
6
Show member pathways
13.1 ANGPT1 FGF2 HGF TEK VEGFA
7
Show member pathways
13.03 ANGPT1 HGF NOS3 PLG TEK VEGFA
8
Show member pathways
13.02 ANGPT1 FGF2 HGF TEK TYMP
9
Show member pathways
12.98 FGF2 HGF NOS3 TEK TYMP VEGFA
10
Show member pathways
12.41 ANGPT1 FGF2 HGF TEK VEGFA
11
Show member pathways
12.25 ANGPT1 FGF2 NOS3 PLG TEK
12 12.17 ANGPT1 FGF2 HGF NOS3 TEK VEGFA
13 12.07 FGF2 HGF VEGFA
14
Show member pathways
12 FGF2 NOS3 VEGFA
15 11.85 FGF2 HGF VEGFA
16 11.76 FGF2 HGF VEGFA
17 11.64 ANGPT1 TEK VEGFA
18 11.55 ANGPT1 NOS3 TEK VEGFA
19 11.3 FGF2 VEGFA
20 11.3 FGF2 PLG VEGFA
21 11.29 FGF2 HGF NOS3 TEK TYMP
22 11.26 FGF2 HGF VEGFA
23
Show member pathways
11.25 HGF VEGFA
24 11.19 ANGPT1 TEK
25 11.18 ANGPT1 VEGFA
26 11.09 FGF2 PLG
27 10.99 FGF2 VEGFA
28 10.4 ANGPT1 FGF2 NOS3 TEK VEGFA

GO Terms for Chronic Myocardial Ischemia

Cellular components related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 ANGPT1 CHGA FGF2 HGF PLG VEGFA
2 extracellular region GO:0005576 9.5 ANGPT1 CHGA FGF2 HGF PLG TEK
3 platelet alpha granule lumen GO:0031093 8.8 HGF PLG VEGFA

Biological processes related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.89 ANGPT1 FGF2 HGF TEK
2 negative regulation of apoptotic process GO:0043066 9.84 ANGPT1 HGF TEK VEGFA
3 MAPK cascade GO:0000165 9.78 ANGPT1 FGF2 HGF TEK
4 in utero embryonic development GO:0001701 9.77 ANGPT1 NOS3 VEGFA
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 ANGPT1 FGF2 TEK
6 peptidyl-tyrosine phosphorylation GO:0018108 9.72 FGF2 HGF TEK
7 platelet degranulation GO:0002576 9.69 HGF PLG VEGFA
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 ANGPT1 HGF VEGFA
9 positive regulation of cell adhesion GO:0045785 9.63 ANGPT1 VEGFA
10 positive regulation of endothelial cell proliferation GO:0001938 9.63 FGF2 TEK VEGFA
11 positive regulation of cell division GO:0051781 9.62 FGF2 VEGFA
12 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.62 HGF NOS3
13 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.61 FGF2 TEK
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.61 ANGPT1 TEK
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.61 ANGPT1 HGF TEK
16 sprouting angiogenesis GO:0002040 9.58 ANGPT1 TEK
17 positive regulation of focal adhesion assembly GO:0051894 9.57 TEK VEGFA
18 positive regulation of receptor internalization GO:0002092 9.56 ANGPT1 VEGFA
19 positive regulation of endothelial cell migration GO:0010595 9.54 ANGPT1 TEK VEGFA
20 cell migration involved in sprouting angiogenesis GO:0002042 9.52 FGF2 VEGFA
21 positive chemotaxis GO:0050918 9.46 ANGPT1 FGF2 HGF VEGFA
22 positive regulation of blood vessel endothelial cell migration GO:0043536 9.43 ANGPT1 FGF2 VEGFA
23 glomerulus vasculature development GO:0072012 9.4 ANGPT1 TEK
24 positive regulation of angiogenesis GO:0045766 9.35 FGF2 HGF NOS3 TEK VEGFA
25 Tie signaling pathway GO:0048014 9.32 ANGPT1 TEK
26 angiogenesis GO:0001525 9.1 ANGPT1 FGF2 NOS3 TEK TYMP VEGFA

Molecular functions related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 FGF2 HGF TYMP VEGFA
2 protein tyrosine kinase activity GO:0004713 9.43 FGF2 HGF TEK
3 chemoattractant activity GO:0042056 9.13 FGF2 HGF VEGFA
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 ANGPT1 FGF2 HGF TEK

Sources for Chronic Myocardial Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....