MCID: CHR068
MIFTS: 34

Chronic Nk-Cell Lymphocytosis

Categories: Immune diseases

Aliases & Classifications for Chronic Nk-Cell Lymphocytosis

MalaCards integrated aliases for Chronic Nk-Cell Lymphocytosis:

Name: Chronic Nk-Cell Lymphocytosis 12 14
Chronic Lymphoproliferative Disorder of Nk-Cells 69
Nk-Cell Large Granular Lymphocyte Lymphocytosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7465
NCIt 46 C39591
UMLS 69 C1512709

Summaries for Chronic Nk-Cell Lymphocytosis

MalaCards based summary : Chronic Nk-Cell Lymphocytosis, also known as chronic lymphoproliferative disorder of nk-cells, is related to b-cell expansion with nfkb and t-cell anergy and transient neonatal neutropenia. An important gene associated with Chronic Nk-Cell Lymphocytosis is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Methotrexate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include nk cells, and related phenotype is hematopoietic system.

Related Diseases for Chronic Nk-Cell Lymphocytosis

Diseases related to Chronic Nk-Cell Lymphocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 b-cell expansion with nfkb and t-cell anergy 30.4 CCL5 FASLG FCGR3B
2 transient neonatal neutropenia 10.5 FCGR3A FCGR3B
3 renal adenoma 10.4 B3GAT1 NCAM1
4 epithelial predominant wilms' tumor 10.4 B3GAT1 NCAM1
5 lethal midline granuloma 10.4 CD2 NCAM1
6 spastic paraplegia 32, autosomal recessive 10.4 B3GAT1 FCGR3A FCGR3B
7 lymphocytic gastritis 10.4 B3GAT1 FASLG
8 diffuse infiltrative lymphocytosis syndrome 10.4 B3GAT1 FCGR3A FCGR3B
9 orbital plasma cell granuloma 10.4 FCGR3A FCGR3B NCAM1
10 chronic orbital inflammation 10.3 FCGR3A FCGR3B NCAM1
11 rheumatic myocarditis 10.3 CD2 FCGR3A FCGR3B
12 pericoronitis 10.3 CD2 NCAM1
13 gastric small cell carcinoma 10.3 B3GAT1 NCAM1
14 adult lymphoma 10.3 CD2 FCGR3A
15 t-cell large granular lymphocyte leukemia 10.2 FASLG NCAM1
16 japanese spotted fever 10.1 CCL4 CCL4L1
17 inflammatory bowel disease 16 10.1 CD2 CD7
18 acute cervicitis 10.1 CCL4 CCL5
19 respiratory syncytial virus infectious disease 10.1 CCL3 CCL5
20 omsk hemorrhagic fever 10.1 CCL4 CCL4L1 CCL5
21 acquired immunodeficiency syndrome 10.1 CCL3 CCR5 FCGR3A
22 folliculitis 10.1 CCL5 FCGR3A
23 exanthema subitum 10.1 CD7 FCGR3A FCGR3B
24 poliomyelitis 10.0 FCGR3A FCGR3B
25 necatoriasis 10.0 CCL3 CCL4
26 orofacial granulomatosis 10.0 CCL3 CCL5 CCR5
27 stachybotrys chartarum 9.9 CCL3 CCL4 CCL5
28 demyelinating disease 9.8 CCL3 CCL4 CCL5
29 thymic dysplasia 9.8 CD2 CD7 IL15
30 sezary's disease 9.8 CD2 CD7 IL15
31 whiplash 9.7 CCL3 CCL4 CCL5 CCR5
32 aleukemic leukemia cutis 9.6 CD7 FUT4 NCAM1
33 systemic lupus erythematosus 9.5 CCL5 CCR5 FASLG FCGR3A FCGR3B ITGAM
34 human immunodeficiency virus infectious disease 9.5 CCL3 CCL4 CCL4L1 CCL5 CCR5
35 pulmonary fibrosis, idiopathic 9.5 CCL3 CCL4 CCL5 CXCR1 FASLG
36 multiple sclerosis 9.4 CCL3 CCL4 CCL5 CCR5 FASLG
37 human immunodeficiency virus type 1 9.3 CCL3 CCL4 CCL5 CCR5 CXCR1 FCGR3B
38 viral infectious disease 9.3 CCL3 CCL4 CCL5 CCR5 IL15
39 leukemia, acute myeloid 9.0 CD2 CD7 FCGR3A FUT4 ITGAM NCAM1

Graphical network of the top 20 diseases related to Chronic Nk-Cell Lymphocytosis:



Diseases related to Chronic Nk-Cell Lymphocytosis

Symptoms & Phenotypes for Chronic Nk-Cell Lymphocytosis

MGI Mouse Phenotypes related to Chronic Nk-Cell Lymphocytosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.28 CXCR1 FASLG FCGR3B FUT4 IL15 ITGAM

Drugs & Therapeutics for Chronic Nk-Cell Lymphocytosis

Drugs for Chronic Nk-Cell Lymphocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
5 Alkylating Agents Phase 2
6 Folic Acid Antagonists Phase 2
7 Cyclosporins Phase 2
8 Nucleic Acid Synthesis Inhibitors Phase 2
9 Dermatologic Agents Phase 2
10 Vitamin B Complex Phase 2
11 Immunosuppressive Agents Phase 2
12 Antimetabolites Phase 2
13 Antimetabolites, Antineoplastic Phase 2
14 Antirheumatic Agents Phase 2
15 Folate Nutraceutical Phase 2
16 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Recruiting NCT01976182 Phase 2 Methotrexate;Cyclophosphamide
2 Registry of the German CLL Study Group Recruiting NCT02863692

Search NIH Clinical Center for Chronic Nk-Cell Lymphocytosis

Genetic Tests for Chronic Nk-Cell Lymphocytosis

Anatomical Context for Chronic Nk-Cell Lymphocytosis

MalaCards organs/tissues related to Chronic Nk-Cell Lymphocytosis:

38
Nk Cells

Publications for Chronic Nk-Cell Lymphocytosis

Articles related to Chronic Nk-Cell Lymphocytosis:

# Title Authors Year
1
Clinicopathological and phenotypic features of chronic NK cell lymphocytosis identified among patients with asymptomatic lymphocytosis. ( 26234181 )
2015
2
Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b. ( 11286541 )
2001

Variations for Chronic Nk-Cell Lymphocytosis

Expression for Chronic Nk-Cell Lymphocytosis

Search GEO for disease gene expression data for Chronic Nk-Cell Lymphocytosis.

Pathways for Chronic Nk-Cell Lymphocytosis

Pathways related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CCL3 CCL4 CCL5 CCR5 CXCR1 FASLG
2
Show member pathways
13.68 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
3
Show member pathways
13.55 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
4
Show member pathways
13.24 CCL3 CCL4 CCL5 CCR5 FASLG IL15
5
Show member pathways
13.17 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
6
Show member pathways
13.1 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
7
Show member pathways
12.79 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
8
Show member pathways
12.44 CCL3 CCL4 CCL4L1 CCL5 FASLG
9 12.43 CCL5 CD2 FASLG NCAM1
10
Show member pathways
12.14 CCR5 FCGR3A FCGR3B ITGAM
11
Show member pathways
12.08 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
12 11.99 FCGR3A FCGR3B ITGAM
13 11.97 CD2 ITGAM NCAM1
14 11.9 CD2 IL15 ITGAM NCAM1
15
Show member pathways
11.87 CCL3 CCL4 CCL5 CCR5 CXCR1
16
Show member pathways
11.82 CCL3 CCL4 CCL4L1 CCR5 FASLG
17 11.77 CD2 CD7 ITGAM
18 11.74 CCL3 CCL5 IL15
19 11.71 CCL3 CCL4 CCL4L1
20 11.57 CCL3 CCL4 CCL5
21 11.5 FCGR3A FCGR3B ITGAM
22 11.47 CCL3 CCL4 CCL5 CCR5
23 11.46 CCL3 CD7 IL15 ITGAM NCAM1
24
Show member pathways
11.18 CCL3 CCL4 FASLG IL15
25 10.98 B3GAT1 FUT4
26 10.46 CCL3 CCL4 CCL4L1 CCL5 CD2 FASLG
27 10.4 CCL3 CCL4 CCL4L1 CCL5 CD2 FASLG

GO Terms for Chronic Nk-Cell Lymphocytosis

Cellular components related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 B3GAT1 CCL3 CCL4 CCL5 CD2 FASLG
2 extracellular space GO:0005615 9.8 CCL3 CCL4 CCL4L1 CCL5 FASLG IL15
3 cell surface GO:0009986 9.5 CCR5 CD2 FASLG FUT4 IL15 ITGAM
4 external side of plasma membrane GO:0009897 9.1 CCR5 CD2 FASLG FCGR3A ITGAM NCAM1

Biological processes related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.93 CCL3 CCL4 CCL4L1 CCL5
2 MAPK cascade GO:0000165 9.91 CCL3 CCL5 CCR5 NCAM1
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 CCL3 CCL4 CCL4L1 CCL5
4 cellular response to tumor necrosis factor GO:0071356 9.85 CCL3 CCL4 CCL4L1 CCL5
5 cell-cell signaling GO:0007267 9.85 CCL3 CCL4 CCL5 CCR5 FASLG IL15
6 calcium ion transport GO:0006816 9.82 CCL3 CCL5 CCR5
7 cellular response to interferon-gamma GO:0071346 9.81 CCL3 CCL4 CCL4L1 CCL5
8 response to toxic substance GO:0009636 9.8 CCL3 CCL4 CCL5
9 chemotaxis GO:0006935 9.8 CCL3 CCL4 CCL5 CCR5 CXCR1
10 cellular response to interleukin-1 GO:0071347 9.78 CCL3 CCL4 CCL4L1 CCL5
11 neutrophil chemotaxis GO:0030593 9.76 CCL3 CCL4 CCL4L1 CCL5
12 positive regulation of calcium ion transport GO:0051928 9.71 CCL3 CCL4 CCL5
13 inflammatory response GO:0006954 9.7 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
14 dendritic cell chemotaxis GO:0002407 9.67 CCL5 CCR5 CXCR1
15 positive regulation of calcium-mediated signaling GO:0050850 9.63 CCL3 CCL4
16 regulation of T cell differentiation GO:0045580 9.62 CD2 IL15
17 monocyte chemotaxis GO:0002548 9.62 CCL3 CCL4 CCL4L1 CCL5
18 macrophage chemotaxis GO:0048246 9.61 CCL3 CCL5
19 negative regulation by host of viral transcription GO:0043922 9.61 CCL3 CCL4 CCL5
20 immune response GO:0006955 9.61 CCL3 CCL4 CCL5 CCR5 CD7 FASLG
21 response to cholesterol GO:0070723 9.6 CCL3 CCR5
22 eosinophil chemotaxis GO:0048245 9.59 CCL3 CCL5
23 signaling GO:0023052 9.58 CCL3 CCR5
24 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.58 CCL3 CCR5
25 negative regulation of macrophage apoptotic process GO:2000110 9.56 CCL5 CCR5
26 positive regulation of natural killer cell chemotaxis GO:2000503 9.43 CCL3 CCL4 CCL5
27 chemokine-mediated signaling pathway GO:0070098 9.1 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
28 G-protein coupled receptor signaling pathway GO:0007186 10.11 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
29 regulation of receptor activity GO:0010469 10 CCL3 CCL4 CCL4L1 CCL5 FASLG IL15

Molecular functions related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 CCL3 CCL4 CCL5 FASLG IL15
2 chemokine activity GO:0008009 9.46 CCL3 CCL4 CCL4L1 CCL5
3 phosphatidylinositol phospholipase C activity GO:0004435 9.43 CCL5 CCR5
4 chemokine receptor activity GO:0004950 9.4 CCR5 CXCR1
5 IgG binding GO:0019864 9.37 FCGR3A FCGR3B
6 phospholipase activator activity GO:0016004 9.32 CCL3 CCL5
7 CCR5 chemokine receptor binding GO:0031730 9.13 CCL3 CCL4 CCL5
8 CCR1 chemokine receptor binding GO:0031726 8.8 CCL3 CCL4 CCL5

Sources for Chronic Nk-Cell Lymphocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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