MCID: CHR068
MIFTS: 33

Chronic Nk-Cell Lymphocytosis malady

Categories: Immune diseases

Aliases & Classifications for Chronic Nk-Cell Lymphocytosis

Aliases & Descriptions for Chronic Nk-Cell Lymphocytosis:

Name: Chronic Nk-Cell Lymphocytosis 12 14
Chronic Lymphoproliferative Disorder of Nk-Cells 69
Nk-Cell Large Granular Lymphocyte Lymphocytosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7465
NCIt 47 C39591
UMLS 69 C1512709

Summaries for Chronic Nk-Cell Lymphocytosis

MalaCards based summary : Chronic Nk-Cell Lymphocytosis, also known as chronic lymphoproliferative disorder of nk-cells, is related to vitamin k deficiency hemorrhagic disease and ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency. An important gene associated with Chronic Nk-Cell Lymphocytosis is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Methotrexate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include nk cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chronic Nk-Cell Lymphocytosis

Diseases related to Chronic Nk-Cell Lymphocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
id Related Disease Score Top Affiliating Genes
1 vitamin k deficiency hemorrhagic disease 10.3 FCGR3A FCGR3B
2 ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency 10.3 B3GAT1 FCGR3A FCGR3B
3 mucinous adenofibroma 10.2 B3GAT1 NCAM1
4 recombinase activating gene 2 deficiency 10.2 FCGR3A FCGR3B NCAM1
5 occipital lobe neoplasm 10.2 CD2 NCAM1
6 peripheral nervous system ganglioneuroblastoma 10.2 B3GAT1 NCAM1
7 spermatocytoma 10.2 B3GAT1 FCGR3A FCGR3B NCAM1
8 skeletal muscle cancer 10.2 B3GAT1 FASLG
9 extragonadal seminoma 10.2 CD2 CD8A FCGR3A
10 cerebrum cancer 10.1 CD2 CD8A NCAM1
11 hyperaldosteronism, familial, type ii 10.1 CCL5 FASLG FCGR3B
12 asynchronous multifocal osteogenic sarcoma 10.1 B3GAT1 CD8A FCGR3A FCGR3B
13 macular degeneration, age-related, 10 10.1 CD2 CD7
14 hereditary retinal dystrophy 10.1 CD2 CD8A FCGR3A FCGR3B
15 anterior foramen magnum meningioma 10.1 CCL3 CCR5 FCGR3A
16 paralytic poliomyelitis 10.1 CCL3 CD8A
17 bulbospinal polio 10.1 CD7 FCGR3A FCGR3B
18 constant exophthalmos 10.1 CCL4 CCL4L1 CCL5
19 osteodysplasty precocious of danks mayne and kozlowski 10.1 CCL3 CCL5 CCR5
20 major depressive disorder and accelerated response to antidepressant drug treatment 10.0 CCR5 CD8A ITGAM
21 steroid dehydrogenase deficiency dental anomalies 9.9 CCL3 CCL4 CCL5
22 cousin syndrome 9.9 CCL5 FASLG FCGR3A FCGR3B ITGAM
23 hypercementosis 9.9 CCL3 CCL5
24 multiple carboxylase deficiency 9.9 CD7 CD8A IL15
25 eating seizures 9.9 CCL3 CCL4 CCL5 CCR5
26 complex regional pain syndrome 9.8 CCL3 CCL4 CCL5
27 squamous cell papilloma of skin 9.8 CD2 CD7 CD8A IL15
28 malignant testicular leydig cell tumor 9.8 CD7 FUT4 NCAM1
29 aortic aneurysm, familial thoracic 6 9.8 CCL3 CCL4 CCL5 FASLG
30 anus leiomyosarcoma 9.8 CCL3 CCL4 CCL4L1 CCL5 CCR5
31 graft-versus-host disease, protection against 9.7 CCL3 CCL4 CCL5 CCR5 CXCR1
32 exophthalmos 9.7 CCL3 CCL4 CCL5 CCR5 IL15
33 cranioectodermal dysplasia 1 9.5 CD2 CD7 CD8A FUT4 ITGAM NCAM1
34 active peptic ulcer disease 7.9 B3GAT1 CCL3 CCL4 CCL4L1 CCL5 CCR5

Graphical network of the top 20 diseases related to Chronic Nk-Cell Lymphocytosis:



Diseases related to Chronic Nk-Cell Lymphocytosis

Symptoms & Phenotypes for Chronic Nk-Cell Lymphocytosis

MGI Mouse Phenotypes related to Chronic Nk-Cell Lymphocytosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 FUT4 IL15 ITGAM CCL5 CCR5 CD7
2 immune system MP:0005387 9.32 CCL5 CCR5 CD7 CD8A CXCR1 FASLG

Drugs & Therapeutics for Chronic Nk-Cell Lymphocytosis

Drugs for Chronic Nk-Cell Lymphocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
4
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
6 Alkylating Agents Phase 2
7 Folic Acid Antagonists Phase 2
8 Nucleic Acid Synthesis Inhibitors Phase 2
9 Dermatologic Agents Phase 2
10 Vitamin B Complex Phase 2
11 Immunosuppressive Agents Phase 2
12 Protein Kinase Inhibitors Phase 1, Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Antirheumatic Agents Phase 2
16 Antineoplastic Agents, Alkylating Phase 2
17 Folate Nutraceutical Phase 2
18 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Recruiting NCT01976182 Phase 2
2 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2
3 Registry of the German CLL Study Group Recruiting NCT02863692

Search NIH Clinical Center for Chronic Nk-Cell Lymphocytosis

Genetic Tests for Chronic Nk-Cell Lymphocytosis

Anatomical Context for Chronic Nk-Cell Lymphocytosis

MalaCards organs/tissues related to Chronic Nk-Cell Lymphocytosis:

39
Nk Cells

Publications for Chronic Nk-Cell Lymphocytosis

Articles related to Chronic Nk-Cell Lymphocytosis:

id Title Authors Year
1
Clinicopathological and phenotypic features of chronic NK cell lymphocytosis identified among patients with asymptomatic lymphocytosis. ( 26234181 )
2015
2
Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b. ( 11286541 )
2001

Variations for Chronic Nk-Cell Lymphocytosis

Expression for Chronic Nk-Cell Lymphocytosis

Search GEO for disease gene expression data for Chronic Nk-Cell Lymphocytosis.

Pathways for Chronic Nk-Cell Lymphocytosis

Pathways related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CCL3 CCL4 CCL5 CCR5 CD8A CXCR1
2
Show member pathways
13.76 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
3
Show member pathways
13.55 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
4
Show member pathways
13.3 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
5
Show member pathways
13.22 CCL3 CCL4 CCL5 CCR5 FASLG IL15
6
Show member pathways
13.17 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
7
Show member pathways
13.1 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
8
Show member pathways
12.8 CCL3 CCL4 CCL4L1 CCL5 FASLG
9
Show member pathways
12.77 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
10 12.42 CCL5 CD2 CD8A FASLG NCAM1
11
Show member pathways
12.15 CCR5 FCGR3A FCGR3B ITGAM
12 12.01 CD2 CD8A ITGAM NCAM1
13
Show member pathways
11.89 CCL3 CCL4 CCL5 CCR5 CXCR1
14 11.79 CD2 CD8A IL15 ITGAM NCAM1
15 11.78 CD2 CD7 CD8A ITGAM
16 11.74 CCL3 CCL5 IL15
17 11.72 CCL3 CCL4 CCL4L1
18
Show member pathways
11.69 CCL3 CCL4 CCL4L1 CCR5 CD8A FASLG
19 11.66 CD8A ITGAM NCAM1
20 11.56 CCL3 CCL4 CCL5
21 11.49 FCGR3A FCGR3B ITGAM
22 11.42 CCL3 CCL4 CCL5 CCR5
23
Show member pathways
11.27 CCL3 CCL4 FASLG IL15
24 11 CCL3 CD7 CD8A IL15 ITGAM NCAM1
25 10.99 B3GAT1 FUT4
26 10.73 CCL3 CCL4 CCL4L1 CCL5 CD2 FASLG

GO Terms for Chronic Nk-Cell Lymphocytosis

Cellular components related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 B3GAT1 CCL3 CCL4 CCL5 CD2 CD8A
2 extracellular space GO:0005615 9.8 CCL3 CCL4 CCL4L1 CCL5 FASLG IL15
3 external side of plasma membrane GO:0009897 9.43 CCR5 CD2 CD8A FASLG FCGR3A NCAM1
4 cell surface GO:0009986 9.23 CCR5 CD2 CD8A FASLG FUT4 IL15
5 membrane GO:0016020 10.17 B3GAT1 CCR5 CD2 CD7 CD8A CXCR1
6 integral component of membrane GO:0016021 10.15 B3GAT1 CCR5 CD2 CD7 CD8A CXCR1

Biological processes related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.92 CCR5 CD2 CD8A CXCR1
2 MAPK cascade GO:0000165 9.91 CCL3 CCL5 CCR5 NCAM1
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 CCL3 CCL4 CCL4L1 CCL5
4 cellular response to tumor necrosis factor GO:0071356 9.85 CCL3 CCL4 CCL4L1 CCL5
5 cell-cell signaling GO:0007267 9.85 CCL3 CCL4 CCL5 CCR5 FASLG IL15
6 chemotaxis GO:0006935 9.83 CCL3 CCL4 CCL5 CCR5 CXCR1
7 cellular response to interleukin-1 GO:0071347 9.81 CCL3 CCL4 CCL4L1 CCL5
8 response to toxic substance GO:0009636 9.8 CCL3 CCL4 CCL5
9 neutrophil chemotaxis GO:0030593 9.78 CCL3 CCL4 CCL4L1 CCL5
10 cellular response to interferon-gamma GO:0071346 9.76 CCL3 CCL4 CCL4L1 CCL5
11 T cell activation GO:0042110 9.73 CD2 CD7 CD8A
12 positive regulation of calcium ion transport GO:0051928 9.71 CCL3 CCL4 CCL5
13 positive regulation of calcium-mediated signaling GO:0050850 9.7 CCL3 CCL4 CD8A
14 inflammatory response GO:0006954 9.7 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
15 dendritic cell chemotaxis GO:0002407 9.67 CCL5 CCR5 CXCR1
16 macrophage chemotaxis GO:0048246 9.62 CCL3 CCL5
17 monocyte chemotaxis GO:0002548 9.62 CCL3 CCL4 CCL4L1 CCL5
18 regulation of T cell differentiation GO:0045580 9.61 CD2 IL15
19 response to cholesterol GO:0070723 9.6 CCL3 CCR5
20 signaling GO:0023052 9.59 CCL3 CCR5
21 eosinophil chemotaxis GO:0048245 9.58 CCL3 CCL5
22 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.58 CCL3 CCR5
23 negative regulation by host of viral transcription GO:0043922 9.58 CCL3 CCL4 CCL5
24 positive regulation of natural killer cell chemotaxis GO:2000503 9.43 CCL3 CCL4 CCL5
25 chemokine-mediated signaling pathway GO:0070098 9.43 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
26 immune response GO:0006955 9.32 CCL3 CCL4 CCL5 CCR5 CD7 CD8A
27 G-protein coupled receptor signaling pathway GO:0007186 10.11 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
28 positive regulation of GTPase activity GO:0043547 10.03 CCL3 CCL4 CCL4L1 CCL5 NCAM1

Molecular functions related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 CCL3 CCL4 CCL5 FASLG IL15
2 chemokine activity GO:0008009 9.46 CCL3 CCL4 CCL4L1 CCL5
3 chemokine receptor activity GO:0004950 9.4 CCR5 CXCR1
4 IgG binding GO:0019864 9.37 FCGR3A FCGR3B
5 phospholipase activator activity GO:0016004 9.32 CCL3 CCL5
6 CCR5 chemokine receptor binding GO:0031730 9.13 CCL3 CCL4 CCL5
7 CCR1 chemokine receptor binding GO:0031726 8.8 CCL3 CCL4 CCL5

Sources for Chronic Nk-Cell Lymphocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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