Chronic Obstructive Pulmonary Disease malady

CDC: Chronic Obstructive Pulmonary Disease, or COPD, refers to a group of diseases that cause airflow blockage and breathing-related problems. It includes emphysema, chronic bronchitis, and in some cases asthma.1²

MalaCards: Chronic Obstructive Pulmonary Disease, also known as pulmonary disease, chronic obstructive, is related to pulmonary disease and copd. An important gene associated with Chronic Obstructive Pulmonary Disease is TSLP (thymic stromal lymphopoietin), and among its related pathways are Transendothelial Migration of Leukocytes and RAR-Gamma-RXR-Alpha Degradation. The compounds nitric oxide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia: Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD),...⁴⁴ more...

OMIM: 606963

chronic obstructive pulmonary disease 8 pulmonary disease, chronic obstructive 33 pulmonary disease chronic obstructive 32

chronic obstructive airway disease 43 lung diseases 43

Diseases related to chronic obstructive pulmonary disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 959)

id	Related Disease	Score	Top Affiliating Genes
1	pulmonary disease	54.6	PIK3CG, PDE4A, REN, RETN, VWF, SFTPA1
2	copd	41.6	PDE4A, VWF, SFTPB, SFTPD, GC, GCLM
3	asthma	39.8	IL13, IL4, IL5, IGES, IGHE, RNASE3
4	interstitial lung disease	38.7	SFTPB, SFTPC, SFTPD, BMP6, ITGAM, IL1RN
5	emphysema	37.7	SFTPB, SFTPC, SFTPD, PCNA, SERPINE2, SERPINA1
6	bronchitis	36.5	SERPINA1, SERPINB1, LACTB, CFTR, MPO, IL5
7	pulmonary hypertension	36.4	PIK3CG, PDE4A, SFTPB, SFTPC, UTS2, FLT1
8	alpha 1-antitrypsin deficiency	35.4	SFTPB, GC, SERPINE2, SERPINI1, SERPINA1, SERPINE1
9	cystic fibrosis lung disease	35.4	MUC5AC, CFTR, MPO, IL8, MBL2, ELANE
10	bronchial asthma	35.1	SFTPD, SELE, SELL, SELP, NAT2, VEGFA
11	carcinoma	35.0	PIK3CG, PDE4A, REN, RETN, VWF, SFTPA1
12	respiratory failure	34.7	PDE4A, SFTPB, SFTPD, SCGB1A1, MUC5AC, LACTB
13	atopic dermatitis	34.6	PDE4A, SELE, SELL, SELP, NAT2, VCAM1
14	bronchiectasis	34.2	SERPINA1, SERPINA3, SERPINB1, SCNN1G, CFTR, MPO
15	idiopathic pulmonary fibrosis	33.5	PCNA, MPO, MMP1, MMP2, FN1, FGF2
16	abdominal aortic aneurysm	33.5	MMP1, MMP12, MMP14, MMP2, MMP3, MMP8
17	allergic asthma	33.0	PDE4A, SFTPD, SELE, SELL, NAT2, VCAM1
18	obstructive lung disease	32.8	PDE4A, REN, SFTPC, SERPINA1, SERPINA3, LACTB
19	pulmonary function	32.7	SFTPB, SERPINA1, LEP, CFTR, MPO, GSTM1
20	cor pulmonale	32.6	REN, VWF, FGF2, CAT, LTA, EDN1
21	pulmonary emphysema	32.4	SFTPD, PCNA, SERPINA1, SERPINB1, VEGFA, MMP1
22	arthritis	32.3	SELL, SERPINA1, MMP3, FGF1, IL17A, IL1B
23	rheumatoid arthritis	31.8	CD40, IL10, IL1B, IL1RN, IL23A, TNF
24	fibrosis	31.6	PIK3CG, PDE4A, REN, RETN, VWF, SFTPA1
25	erythrocytosis	31.2	REN, SELP, IL11, NOS3, ACE, HIF1A
26	dermatitis	31.1	PDE4A, SFTPD, SELE, SELL, SELP, NAT2
27	usual interstitial pneumonia	30.5	SFTPC, FGF2, IL13, IL8, CCL2, IFNG
28	aspergillosis	30.4	SFTPA1, SFTPD, CFTR, CD79A, IL10, IL17A
29	bronchiolitis obliterans	30.3	SFTPA1, SFTPD, BMP6, SCGB1A1, CHKB, MMP8
30	cork-handlers' disease	30.2	SFTPC, SERPINE1, VEGFA, CFTR, AVP, MPO
31	congestive heart failure	30.1	PIK3CG, REN, UTS2, CHRM2, CHKB, MUC16
32	idiopathic interstitial pneumonia	30.1	SFTPC, SFTPD, SERPINE1, VEGFA, SCGB1A1, IL13
33	pulmonary alveolar proteinosis	30.1	SFTPA1, SFTPB, SFTPC, SFTPD, VDR, MMP9
34	mesangial proliferative glomerulonephritis	30.1	VEGFA, CD79A, FGF2, IL6, MAPK1, CCL2
35	bronchiolitis	29.9	SFTPA1, SFTPB, SFTPC, SFTPD, SELE, SELL
36	allergic bronchopulmonary aspergillosis	29.9	SFTPD, CFTR, IL4, IL5, MBL2, IGES
37	proliferative glomerulonephritis	29.8	SELP, VEGFA, MPO, CD79A, FGF2, IL6
38	cystic fibrosis	29.7	PIK3CG, PDE4A, REN, VWF, SFTPA1, SFTPB
39	immunodeficiency	29.7	SELL, BMP6, PARP1, CHRM2, CD79A, CD80
40	aortic aneurysm	29.7	REN, RETN, VWF, SELE, SELL, SERPINE1
41	haemophilus influenzae	29.7	PIK3CG, MUC5AC, LBP, LACTB, MPO, FN1
42	muscular atrophy	29.6	PARP1, BCL2, CHAT, CHKB, FOXO1, IL5
43	sarcoidosis	29.5	SFTPD, SELE, SELL, SELP, SERPINA3, VEGFA
44	pulmonary fibrosis	29.5	VWF, SFTPA1, SFTPB, SFTPC, SFTPD, SELE
45	hypertension	29.5	PIK3CG, PDE4A, REN, RETN, VWF, SFTPB
46	diffuse panbronchiolitis	29.3	GC, MUC5AC, MUC5B, MPO, CD79A, IL13
47	panbronchiolitis	29.3	GC, MUC5AC, MUC5B, MPO, CD79A, IL13
48	pulmonary sarcoidosis	29.3	SFTPD, SELL, CD80, ITGAL, ITGAM, IL18
49	polycythemia	29.2	PIK3CG, VWF, SELP, SERPINE1, VEGFA, LCN2
50	lung carcinoma	29.2	PIK3CG, SFTPB, SFTPD, PCNA, RBP4, SELL

Clinical features from OMIM: 606963

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

Human bone marrow-derived mesenchymal stem cells , PMIDs: 21311694, 21653527

MalaCards organs/tissues related to chronic obstructive pulmonary disease:

²²

MGI Mouse Phenotypes related to chronic obstructive pulmonary disease:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	12.8	SFTPC, SFTPD, SELL, SELP, SERPINB1, MYOG
2	hematopoietic system phenotype	MP:0005397	12.3	PCNA, SERPINB1, BDKRB2, BCL2, CHUK, LCN2
3	normal phenotype	MP:0002873	11.3	REN, BTC, RBP4, SELE, VEGFA, VCAN
4	endocrine/exocrine gland phenotype	MP:0005379	11.3	SELL, SERPINE2, RARG, BDKRB2, CHRM3, XDH
5	mortality/aging	MP:0010768	11.0	REN, VWF, SFTPB, SFTPC, SFTPD, GCLM
6	nervous system phenotype	MP:0003631	11.0	PDE4A, REN, VWF, SELP, SERPINE2, VCAN
7	behavior/neurological phenotype	MP:0005386	10.9	REN, SFTPB, SFTPC, SELE, SELP, SERPINE2
8	immune system phenotype	MP:0005387	10.9	PDE4A, REN, VWF, SELL, SELP, SELPLG
9	craniofacial phenotype	MP:0005382	10.7	RARG, CFTR, FOXO1, IL17A, IL17F, MAPK8
10	embryogenesis phenotype	MP:0005380	10.7	MYOG, RARG, PARP1, CHUK, XRCC1, FOXO1
11	renal/urinary system phenotype	MP:0005367	10.6	REN, SELP, SELPLG, BDKRB2, BCL2, SCGB1A1
12	liver/biliary system phenotype	MP:0005370	10.1	RETN, VEGFA, CHRM2, CHRM3, LBP, CFTR
13	homeostasis/metabolism phenotype	MP:0005376	9.7	PIK3CG, REN, RETN, VWF, SFTPB, SFTPD
14	other phenotype	MP:0005395	9.6	RARG, SCNN1G, LEPR, MMP14, FN1, IL13
15	digestive/alimentary phenotype	MP:0005381	9.6	VWF, VEGFA, VDR, MYO1A, RARG, BDKRB2
16	integument phenotype	MP:0010771	9.2	PIK3CG, SELP, SELPLG, MYOG, RARG, PARP1
17	no phenotypic analysis	MP:0003012	9.1	SFTPC, PCNA, SERPINE2, VEGFA, VCAM1, MYOD1
18	hearing/vestibular/ear phenotype	MP:0005377	9.1	VDR, MYO1A, RARG, PARP1, BCL2, CKMT1B
19	tumorigenesis	MP:0002006	9.0	SFTPC, SELL, SERPINE1, BCL2, SCGB1A1, LEP
20	growth/size phenotype	MP:0005378	8.5	PIK3CG, REN, SFTPC, SFTPD, BTC, SELE
21	skeleton phenotype	MP:0005390	8.5	PIK3CG, GC, BTC, VEGFA, VDR, VCAN
22	adipose tissue phenotype	MP:0005375	8.5	RETN, SERPINE1, MYOG, MYOD1, BDKRB2, BCL2
23	reproductive system phenotype	MP:0005389	8.2	REN, SFTPC, RBP4, SERPINE2, VEGFA, VDR
24	vision/eye phenotype	MP:0005391	6.5	SFTPC, RBP4, SELE, SELP, VEGFA, RARG
25	cardiovascular system phenotype	MP:0005385	6.1	PIK3CG, PDE4A, REN, VWF, SFTPC, BTC
26	muscle phenotype	MP:0005369	6.1	PIK3CG, REN, BTC, RBP4, VEGFA, MYOG
27	cellular phenotype	MP:0005384	6.0	PIK3CG, VWF, PCNA, GCLM, RBP4, SELE

Articles related to chronic obstructive pulmonary disease:

(show top 50)    (show all 585)

id	Title	Authors	Year	Affiliating Genes
1	Leptin and activity of tumor necrosis factor alpha r elations with parameters of the trophologic status and digestion in patients wi th chronic obstructive pulmonary disease]. (21675251)		2011	TNF, LEP
2	Role of glucocorticoid receptor and nuclear factor-k appaB in patients with stable chronic obstructive pulmonary disease (20450542)	Liu T.... Cai B.Q.	2010	NR3C1
3	Genetic polymorphisms of the serotonin transporter, b ut not the 2a receptor or nitric oxide synthetase, are associated with pulmonar y hypertension in chronic obstructive pulmonary disease. (19556740)	Ulrich S.... Speich R.	2010	NOS3, SLC6A4, HTR2A
4	The 15q24/25 susceptibility variant for lung cancer a nd chronic obstructive pulmonary disease is associated with emphysema. (20007924)	Lambrechts D.... Janssens W.	2010	CHRNA3
5	Surfactant protein-B 121ins2 heterozygosity, reduced pulmonary function, and chronic obstructive pulmonary disease in smokers. (19833825)	Baekvad-Hansen M.... Nordestgaard B.G.	2010	SFTPB
6	Adiponectin as a biomarker of systemic inflammatory response in smoker patients with stable and exacerbation phases of chronic obstructive pulmonary disease. (18946779)	Kirdar S.... KaradaA9 F.	2009	CRP, ADIPOQ
7	C-reactive protein levels, haplotypes, and the risk of incident chronic obstructive pulmonary disease. (19096002)	van Durme Y.M.... Stricker B.H.	2009	CRP
8	Polymorphisms of the beta2 adrenoreceptor gene in chronic obstructive pulmonary disease. (19293197)	Vacca G.... Gillissen A.	2009	ADRB2
9	Serum biomarkers as predictors of lung function decli ne in chronic obstructive pulmonary disease. (19249197)	Higashimoto Y.... Tohda Y.	2009	MMP9, ELANE
10	Detection and clinical significance of vascular cell adhesion molecules-1 in chronic obstructive pulmonary disease]. (18846968)	Pan L.... Liu X.C.	2008	VCAM1
11	Determination and clinical implication of leukotriene B(4) and tumor necrosis factor-alpha in condensate of exhaled breath of chronic obstructive pulmonary disease patients (18549718)	Chen J.L.... Tao G.H.	2008	TNF
12	Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive pulmonary disease). (18518838)	Roghanian A.... Sallenave J.M.	2008	ELANE
13	Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms. (18467512)	Togo S.... Rennard S.I.	2008	TGFB1, PTGER4
14	Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive pulmonary disease. (18635880)	Green H.J.... Webb K.A.	2008	SLC2A4, SLC16A4
15	Pulmonary and systemic hepatocyte and keratinocyte growth factors in patients with chronic obstructive pulmonary disease. (19281086)	Sauleda J.... AgustA- A.G.	2008	HGF, FGF7
16	Efficacy and safety of formoterol for the treatment o f chronic obstructive pulmonary disease. (18023995)	Berger W.E.... Nadel J.A.	2008	ADRB2
17	Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. (18424749)	Nakao I.... Izuhara K.	2008	MUC5AC, SLC26A4
18	C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. (17053205)	Dahl M.... Nordestgaard B.G.	2007	CRP
19	Effect of Na(+)/Ca(2+) exchange blocker, Benzamil, on alveolar macrophage function in patients with chronic obstructive pulmonary disease (17767818)	Li X.... Song M.J.	2007	TNF
20	The relationship between inflammatory markers and disability in chronic obstructive pulmonary disease (COPD). (17665081)	Garrod R.... Hagan G.	2007	CRP
21	Diuretics, plasma brain natriuretic peptide and chronic obstructive pulmonary disease. (17890789)	Kanat F.... Teke T.	2007	NPPB
22	Vascular endothelial growth factor: an angiogenic factor reflecting airway inflammation in healthy smokers and in patients with bronchitis type of chronic obstructive pulmonary disease? (17631682)	Rovina N.... Gratziou C.	2007	TNF, VEGFA
23	Interleukin-6 gene polymorphism confers susceptibility to pulmonary hypertension in chronic obstructive pulmonary disease. (16921112)	Eddahibi S.... Adnot S.	2006	IL6
24	Inhaled fluticasone and salmeterol suppress eosinophilic airway inflammation in chronic obstructive pulmonary disease: relations with lung function and bronchodilator reversibility. (17006748)	Perng D.W.... Tao C.W.	2006	RNASE3
25	Expression of mitogen-actived protein kinase, phosphatidylinositol 3-kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic obstructive pulmonary disease (17045016)	Kong C.C.... Dai A.G.	2006	PIK3CG, HIF1A, EIF2AK3
26	Serum resistin and leptin in patients with chronic obstructive pulmonary disease and their relationship to nutritional state (16115391)	Wang Q.Y.... Yu R.J.	2005	LEP, RETN
27	Complex search for antiprotease-protease enzyme gene polymorphisms in patients with chronic obstructive pulmonary diseases (15612581)	Ianbaeva D.G.... Viktorova T.V.	2004	SERPINA1, MMP1, SERPINA3
28	The levels and clinical implications of induced sputum interleukin-17 in chronic obstructive pulmonary disease and asthma (15730730)	Shen F.... Yao W.Z.	2004	IL17A
29	Heat shock protein 70 gene polymorphisms in Han nationality of China with chronic obstructive pulmonary diseases. (15165109)	Xie J.... Chen S.	2004	HSPA1A, HSPA1B, HSPA1L
30	CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. (14985398)	Hegab A.E.... Sekizawa K.	2004	CLCA1
31	Protective and therapeutic effect of pulmonary surfactant on the experimental chronic obstructive pulmonary disease in hamsters (15266830)	Li L.... Chen Y.	2004	ELANE, PTGER1
32	A promotor polymorphism in the Interleukin 11 gene is associated with chronic obstructive pulmonary disease. (15004839)	Klein W.... Epplen J.T.	2004	IL11
33	Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease. (12952261)	Gosker H.R.... Schols A.M.	2003	CASP3
34	Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease. (14530202)	Eddahibi S.... Adnot S.	2003	SLC6A4
35	Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. (12654609)	Sin D.D.... Man S.F.	2003	CRP
36	Animal models of chronic obstructive pulmonary disease: some critical remarks. (12771509)	Fehrenbach H.	2002-2003	ELANE
37	Evaluation of collagenase activity, matrix metalloproteinase-8, and matrix metalloproteinase-13 in horses with chronic obstructive pulmonary disease. (11453493)	Raulo S.M.... Maisi P.S.	2001	MMP8
38	Genetics of chronic obstructive pulmonary disease. (11199103)	Silverman E.K.	2001	SERPINA1
39	Interleukin-4 and tumour necrosis factor-alpha inhibit transforming growth factor-beta production in a human bronchial epithelial cell line: possible relevance to inflammatory mechanisms in chronic obstructive pulmonary disease. (11555378)	Hodge S.... Scicchitano R.	2001	TNF
40	Association of tumor necrosis factor alpha gene promoter polymorphism with the presence of chronic obstructive pulmonary disease. (11179116)	Sakao S.... Kuriyama T.	2001	TNF
41	Decreased osteocalcin levels in patients with chronic obstructive pulmonary disease using long-term inhaled beclomethasone dipropion ate. (11699053)	Dinc M.... Oz M.	2001	BGLAP
42	Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. (10934109)	Ichinose M.... Shirato K.	2000	NOS2
43	The relationship between chronic hypoxemia and activation of the tumor necrosis factor-alpha system in patients with chronic obstructive pulmonary disease. (10764309)	Takabatake N.... Tomoike H.	2000	TNF
44	The significance of inflammatory markers in sputum of asthmatic and chronic obstructive pulmonary diseases patients before and after glucocorticoid treatment (11798648)	Ma M.... Li H.	1999	IL5, RNASE3
45	Value of C-reactive protein measurements in exacerbations of chronic obstructive pulmonary disease. (9659534)	Dev D.... Emmanuel F.X.	1998	CRP
46	Micellar electrokinetic chromatography for the determination of urinary desmosine and isodesmosine in patients affected by chronic obstructive pulmonary disease. (9746238)	Viglio S.... Iadarola P.	1998	ELN
47	Plasma levels of atrial natriuretic peptide and brain natriuretic peptide following intravenous saline infusion in oedematous chronic obstructive pulmonary disease and non-oedematous chronic obstructive pulmonary disease. (8933657)	Sheedy W.... Morice A.H.	1996	NPPB, NPPA
48	Sex hormone responses in healthy men and male patients with chronic obstructive pulmonary disease during an oral glucose load. (8981659)	Hjalmarsen A.... Jorde R.	1996	SHBG
49	Determination of plasma endothelin-1 in aged patients with chronic obstructive pulmonary disease in its clinical significance (7923434)	Feng C.S.... Zeng Q.	1993	EDN1
50	Erythropoietin in chronic obstructive pulmonary disease. Relationship between serum erythropoietin, blood hemoglobin and lung function--effect of the calcium antagonist isradipine on serum erythropoietin. (1836066)	Graudal N.... Nielsen O.J.	1991	EPO

Genes related to chronic obstructive pulmonary disease according to GeneCards:

(show top 50)    (show all 369)

id	Symbol	Description	Score	GeneCards Section Context
1	TSLP	thymic stromal lymphopoietin	11.1	Summaries, Publications
2	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	11.1	Summaries, Publications
3	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.1	Publications, Summaries
4	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.1	Summaries, Publications
5	HHIP	hedgehog interacting protein	11.1	Summaries
6	COPD16	Chronic obstructive pulmonary disease QTL 16	11.1	Aliases & Descriptions, Publications
7	COPD13	Chronic obstructive pulmonary disease QTL 13	11.1	Publications, Aliases & Descriptions
8	COPD6	Chronic obstructive pulmonary disease QTL 6	11.1	Aliases & Descriptions, Publications
9	COPD11	Chronic obstructive pulmonary disease QTL 11	11.1	Aliases & Descriptions, Publications
10	COPD8	Chronic obstructive pulmonary disease QTL 8	11.1	Publications, Aliases & Descriptions
11	COPD5	Chronic obstructive pulmonary disease QTL 5	11.1	Aliases & Descriptions, Publications
12	COPD7	Chronic obstructive pulmonary disease QTL 7	11.1	Publications, Aliases & Descriptions
13	COPD18	Chronic obstructive pulmonary disease QTL 18	11.1	Aliases & Descriptions, Publications
14	COPD9	Chronic obstructive pulmonary disease QTL 9	11.1	Publications, Aliases & Descriptions
15	COPD10	Chronic obstructive pulmonary disease QTL 10	11.1	Publications, Aliases & Descriptions
16	COPD24	Chronic obstructive pulmonary disease QTL 24	11.1	Aliases & Descriptions
17	COPD20	Chronic obstructive pulmonary disease QTL 20	11.1	Aliases & Descriptions, Publications
18	COPD17	Chronic obstructive pulmonary disease QTL 17	11.1	Aliases & Descriptions, Publications
19	COPD26	Chronic obstructive pulmonary disease QTL 26	11.1	Aliases & Descriptions
20	COPD15	Chronic obstructive pulmonary disease QTL 15	11.1	Publications, Aliases & Descriptions
21	COPD14	Chronic obstructive pulmonary disease QTL 14	11.1	Aliases & Descriptions, Publications
22	COPD12	Chronic obstructive pulmonary disease QTL 12	11.1	Aliases & Descriptions, Publications
23	COPD25	Chronic obstructive pulmonary disease QTL 25	11.1	Aliases & Descriptions
24	COPD29	Chronic obstructive pulmonary disease QTL 29	11.1	Aliases & Descriptions
25	COPD28	Chronic obstructive pulmonary disease QTL 28	11.1	Aliases & Descriptions
26	COPD27	Chronic obstructive pulmonary disease QTL 27	11.1	Aliases & Descriptions
27	COPD3	Chronic obstructive pulmonary disease QTL 3	11.1	Publications, Aliases & Descriptions
28	COPD2	Chronic obstructive pulmonary disease QTL 2	11.1	Aliases & Descriptions, Publications
29	COPD19	Chronic obstructive pulmonary disease QTL 19	11.1	Aliases & Descriptions, Publications
30	COPD4	Chronic obstructive pulmonary disease QTL 4	11.1	Aliases & Descriptions, Publications
31	COPD1	Chronic obstructive pulmonary disease QTL 1	11.1	Aliases & Descriptions, Publications
32	COPD22	Chronic obstructive pulmonary disease QTL 22	11.1	Publications, Aliases & Descriptions
33	COPD23	Chronic obstructive pulmonary disease QTL 23	11.1	Publications, Aliases & Descriptions
34	COPD21	Chronic obstructive pulmonary disease QTL 21	11.1	Publications, Aliases & Descriptions
35	DNTTIP2	deoxynucleotidyltransferase, terminal, interacting protein 2	11.1	Summaries
36	COPD	Pulmonary disease, chronic obstructive, severe early-onset	11.0	Publications
37	MBL3P	mannose-binding lectin family member 3, pseudogene	11.0	Publications
38	CRLF2	cytokine receptor-like factor 2	11.0	Publications
39	GPR182	G protein-coupled receptor 182	11.0	Publications
40	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0	Publications
41	EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	11.0	Publications
42	AQP5	aquaporin 5	11.0	Publications
43	CKMT1B	creatine kinase, mitochondrial 1B	11.0	Publications
44	TMEM169	transmembrane protein 169	11.0	Publications
45	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
46	TCEAL1	transcription elongation factor A (SII)-like 1	11.0	Publications
47	MYO1A	myosin IA	11.0	Publications
48	TBX4	T-box 4	11.0	Publications
49	MMP12	matrix metallopeptidase 12 (macrophage elastase)	11.0	Publications
50	IL27	interleukin 27	11.0	Publications

Pathways related to chronic obstructive pulmonary disease according to GeneDecks:

(show top 50)    (show all 157)

id	Pathway	Score	Top Affiliating Genes
1	Transendothelial Migration of Leukocytes36	11.8	VCAM1, MYO1A, ITGAL, ITGAM, ITGB2, MMP1
2	RAR-Gamma-RXR-Alpha Degradation36	11.8	RARG, CD80, IL11, IL12A, IL16, IL22
3	Chemokine signaling pathway20	11.6	PIK3CG, CHUK, IL8, MAPK1, CCR6, CCL2
4	Chemokine Signaling36	11.6	JUN, IL8, MAPK8, MAPK14, MAPK1, CCR6
5	Antioxidant Action of Vitamin-C36	11.6	BTC, MYO1A, BMP6, UTS2, BCL2, CHUK
6	Cytokine-cytokine receptor interaction20	11.3	VEGFA, LEP, LEPR, CD27, CD40, FLT1
7	Jak-STAT signaling pathway20	11.2	PIK3CG, LEP, LEPR, IL10, IL11, IL12A
8	Tec Kinases Signaling36	11.1	BTC, BMP6, UTS2, BCL2, CD80, ITGAL
9	IL-6 Pathway36	11.1	BMP6, CD80, IL10, IL11, IL12A, IL16
10	Regulation of eIF4 and p70S6K36	11.0	CD80, ITGAL, ITGAM, ITGB2, FGF1, FGF7
11	all-trans-Retinoic Acid Signaling in Brain36	11.0	BMP6, RARG, BCL2, CD80, IL10, IL11
12	Amoebiasis20	11.0	SERPINB1, ITGAM, ITGB2, FN1, IL12A, IL1B
13	PAK Pathway36	11.0	BTC, MYO1A, BMP6, UTS2, BCL2, CD80
14	STAT3 Pathway36	10.9	BMP6, BCL2, CDKN1A, CD80, IL10, IL11
15	Glioma Invasiveness36	10.9	BTC, BMP6, UTS2, ITGAL, ITGAM, ITGB2
16	Rho Family GTPases36	10.8	BTC, BMP6, UTS2, BCL2, JUN, CD80
17	Immune response_TLR signaling pathways41	10.8	SFTPA1, CHUK, LBP, JUN, FN1, IL11
18	ERK Signaling36	10.8	BTC, BMP6, UTS2, CHUK, CD80, ITGAL
19	NFAT Signaling and Lymphocyte Interactions36	10.6	BMP6, BCL2, CD80, IL11, IL12A, IL13
20	PEDF Induced Signaling36	10.6	BMP6, BCL2, CHUK, CD80, IL10, IL11
21	NF-KappaB (p50-p65) Pathway36	10.6	BTC, BMP6, UTS2, CHUK, FLT1, FGF1
22	Toll-like receptor signaling pathway20	10.4	PIK3CG, CHUK, LBP, JUN, CD86, CD80
23	MIF Mediated Glucocorticoid Regulation36	10.4	BMP6, BCL2, CD80, IL10, IL11, IL12A
24	Endothelin-1 Signaling Pathway36	10.3	BMP6, CD80, FLT1, IL10, IL11, IL12A
25	p38 Signaling36	10.3	BTC, BMP6, UTS2, BCL2, CD80, FLT1
26	PPAR Pathway36	10.2	BTC, UTS2, ITGAL, ITGAM, ITGB2, FLT1
27	PGC1Alpha Pathway36	10.2	BMP6, BCL2, CD80, IL11, IL12A, IL13
28	TGF-Beta Pathway36	10.1	BTC, BMP6, UTS2, BCL2, JUN, CD80
29	Phospholipase-C Pathway36	10.0	BTC, BMP6, UTS2, CD79A, ITGAL, ITGAM
30	MAPK Family Pathway36	10.0	BTC, BMP6, UTS2, BCL2, CHUK, JUN
31	DHA Signaling36	10.0	BTC, BMP6, UTS2, BCL2, FOXO1, FLT1
32	Rheumatoid arthritis20	9.9	VEGFA, JUN, CD86, CD80, ITGAL, ITGB2
33	Chagas disease (American trypanosomiasis)20	9.8	PIK3CG, SERPINE1, BDKRB2, CHUK, JUN, IL10
34	ILK Signaling36	9.8	BTC, MYO1A, UTS2, JUN, CDH15, ITGAM
35	Glucocorticoid Receptor Signaling36	9.8	BMP6, BCL2, JUN, CDKN1A, CD80, IL10
36	JNK Pathway36	9.8	BTC, BMP6, UTS2, BCL2, JUN, CD80
37	Malaria20	9.8	SELE, SELP, VCAM1, CD40, ITGAL, ITGB2
38	Pertussis20	9.7	SFTPA1, JUN, ITGAM, ITGB2, IL10, IL12A
39	SOCS Pathway36	9.7	BMP6, BCL2, CD80, FGF1, FGF2, FGF7
40	MIF Regulation of Innate Immune Cells36	9.6	BMP6, BCL2, JUN, CD80, IL10, IL11
41	Molecular Mechanisms of Cancer36	9.6	PIK3CG, BMP6, UTS2, BCL2, JUN, CDKN1A
42	JAK-STAT Pathway36	9.6	BTC, BMP6, UTS2, BCL2, JUN, CD80
43	Immune response_MIF-mediated glucocorticoid regulation41	9.5	VCAM1, CHUK, JUN, MMP1, IL6, IL8
44	Renin-Angiotensin Pathway36	9.5	REN, BTC, VCAM1, BMP6, UTS2, CHUK
45	Toxoplasmosis20	9.1	PIK3CG, BCL2, CHUK, CD40, IL10, IL12A
46	MAPK Signaling36	9.0	BTC, BMP6, UTS2, BCL2, CHUK, JUN
47	Tuberculosis20	8.8	VDR, BCL2, LBP, ITGAM, ITGB2, IL10
48	Pancreatic Adenocarcinoma36	8.7	BTC, BMP6, UTS2, BCL2, CDKN1A, MMP1
49	Colorectal Cancer Metastasis36	8.2	CDKN1A, MMP1, MMP12, MMP14, MMP2, MMP9
50	Pathways in cancer20	7.9	PIK3CG, VEGFA, BCL2, CHUK, JUN, CDKN1A

Compounds related to chronic obstructive pulmonary disease according to GeneDecks:

(show top 50)    (show all 553)

id	Compound	Score	Top Affiliating Genes
1	nitric oxide32 9 18 9	17.2	PDE4A, REN, RETN, SFTPB, SFTPD, GCLM
2	estrogen32	12.3	RETN, VWF, PCNA, GC, RBP4, SERPINA1
3	superoxide32 18	12.8	PDE4A, GC, SELL, SERPINA3, SERPINB1, VCAM1
4	fmlp32	11.7	PIK3CG, PDE4A, GC, SELL, SELP, SELPLG
5	dopamine32 9 18 9	14.6	PDE4A, REN, RBP4, SELE, SERPINA3, BMP6
6	acetylcholine32 9 18 9	14.6	PDE4A, VWF, SERPINE2, SERPINA3, MYOG, MYOD1
7	glucose32	11.5	PDE4A, BTC, VCAN, MYOG, MYOD1, CHUK
8	ccl432	11.5	IL13, IL16, IL17A, CCR6, CCL2, CCR4
9	nadph32 18	12.5	UTS2, BDKRB2, SDHB, CHAT, XRCC1, GLRX
10	p00232	11.3	RETN, RBP4, SCGB1A1, LEP, XRCC1, ITGAM
11	salbutamol32 34 9 18 9	15.3	PDE4A, VCAM1, CHKB, UCP3, CD79A, ITGB2
12	polyacrylamide32	11.1	SFTPB, GC, RBP4, SERPINA1, SERPINA3, VCAN
13	nicotine32 34 9 9	14.0	SELL, CYP1A2, CYP2E1, CYP2D6, SLC22A4, SLC22A5
14	n-formylmethionyl-leucylphenylalanine32	11.0	PIK3CG, SELL, SELP, SELPLG, LCN2, MPO
15	nifedipine32 9 9	13.0	PIK3CG, REN, SELE, SERPINE1, BMP6, BGLAP
16	vitamin-e32	10.6	RBP4, VCAM1, CD40, MMP12, GSR, GSTT1
17	polyethylene glycol32	10.6	SELE, CHKB, MPO, FN1, HSPD1, HMOX1
18	pravastatin32 34 9 18 9	14.5	SELE, SELP, SERPINE1, CHKB, ITGAL, IL18
19	estradiol32 9 18 9	13.5	REN, PCNA, GC, SERPINE1, SERPINA3, LEPR
20	homocysteine32 18	11.4	RETN, VWF, SELE, SELP, SERPINE1, NAT2
21	agar32	10.4	LACTB, MMP14, FN1, FGF1, FGF2, FGF7
22	cocaine32 9 9	12.4	PDE4A, SELE, SELP, VCAM1, BMP6, LEP
23	salicylic acid32	10.3	PIK3CG, SERPINA1, VDR, CHUK, XDH, CFTR
24	neopterin32	10.2	CHKB, LCN2, CD79A, CD40, GZMB, IL10
25	phorbol32	10.2	RBP4, SELL, CHUK, JUN, CDKN1A, CD40
26	8-isoprostane32	10.2	RETN, SELE, SERPINE1, VCAM1, LEP, XDH
27	rottlerin32 42	11.1	PIK3CG, VCAM1, PARP1, JUN, ITGAM, IL8
28	dextran sulfate32	10.1	SELE, SELL, SELP, MPO, FN1, FGF1
29	losartan32 34 9 9	13.1	REN, VWF, PCNA, SELE, SELP, SERPINE1
30	lactate32	10.0	VWF, SFTPD, PCNA, RBP4, SELE, SELL
31	glycerol32 9 18 9	12.9	PDE4A, VWF, PCNA, LEP, CHKB, CHUK
32	okt332	9.9	SELE, VCAM1, BMP6, CD79A, ITGB2, IL10
33	rolipram32 42	10.9	PDE4A, SELE, SELL, ITGAM, ITGB2, IL10
34	hydrocortisone32 9 9	11.6	REN, BMP6, BGLAP, CD40, MMP1, MMP2
35	tgf beta132	9.5	SERPINE1, VCAM1, VCAN, MYOD1, BMP6, CDKN1A
36	calcitriol32 42 9 18 9	13.5	REN, GC, VDR, BMP6, BGLAP, LBP
37	atorvastatin32 34 9 18 9	13.5	RETN, VWF, SELE, SELL, SELP, SERPINE1
38	ribavirin32 34 9 9	12.4	LEP, MMP1, MMP2, MMP9, IL10, IL18
39	radicicol32 42 9 9	12.3	PIK3CG, VEGFA, UTS2, JUN, MAPK1, HSP90AA1
40	matrigel32	9.0	PIK3CG, VWF, BTC, SELE, SERPINE1, VEGFA
41	paraffin32	9.0	VWF, SFTPB, PCNA, SELL, SERPINA1, SERPINA3
42	simvastatin32 34 42 9 18 9	13.8	VWF, RBP4, SELE, SELL, SELP, SERPINE1
43	wortmannin32 42	9.7	PIK3CG, PDE4A, BTC, VCAM1, BCL2, LEP
44	herbimycin a32 42	9.2	PIK3CG, SELE, SELL, VCAM1, BMP6, JUN
45	geldanamycin32 9 9	10.2	PIK3CG, VEGFA, MYOD1, PARP1, JUN, CDKN1A
46	celecoxib32 42 34 9 18 9	12.6	PIK3CG, REN, PCNA, VEGFA, PARP1, BCL2
47	bortezomib32 9 9	9.6	VEGFA, PARP1, BCL2, CHUK, JUN, CDKN1A
48	butyrate32	7.3	PCNA, VDR, MYOG, MYOD1, BMP6, BCL2
49	5fluorouracil32	7.2	PIK3CG, PCNA, SELE, VEGFA, VDR, BCL2
50	genistein32 9 18 9	9.5	PIK3CG, PCNA, SELE, SELL, SELP, SERPINE1

Cellular components related to chronic obstructive pulmonary disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	12.6	SPP1, IL6, IL5, IL22, IL1B, IL18
2	integral to plasma membrane	GO:005887	12.4	AQP5, FGFR1, FLT1, MMP14, CCR6, CCR4
3	extracellular space	GO:005615	11.4	CTGF, CCL20, CCL11, CCL2, MBL2, APOH
4	plasma membrane	GO:005886	10.8	CTGF, PTGS1, PTGER4, PTGER1, TNF, TRPV4
5	external side of plasma membrane	GO:009897	10.6	VWF, IFNG, ICAM1, TNF, CTLA4, ACE
6	secretory granule	GO:030141	10.3	ELANE, VEGFA, IL1B, MPO, HSPD1, LTF
7	platelet alpha granule lumen	GO:031093	9.4	SERPINA1, SERPINE1, FN1, EGF, TIMP1, TGFB1
8	cytosol	GO:005829	7.6	PIK3CG, FGFR1, FGF1, GSTT1, GSTP1, GSTO2

Biological processes related to chronic obstructive pulmonary disease according to GeneDecks:

(show all 50)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	12.2	BMP6, CHUK, CD86, GZMA, IL12A, IL13
2	inflammatory response	GO:006954	12.1	PIK3CG, SELE, SELP, SERPINA3, BMP6, PARK7
3	cell-cell signaling	GO:007267	11.7	NAMPT, AVP, CD86, CD80, ITGB2, IL10
4	elevation of cytosolic calcium ion concentration	GO:007204	11.6	UTS2, BDKRB2, AVP, IL1B, CCR6, CCR4
5	chemotaxis	GO:006935	11.5	FGF2, IL4, MAPK14, MAPK1, CCR6, CCL2
6	cell adhesion	GO:007155	11.4	VWF, SELL, SELP, SELPLG, VCAM1, VCAN
7	response to lipopolysaccharide	GO:032496	11.2	SFTPB, SFTPC, SELE, SELP, SERPINA1, LBP
8	chemokine-mediated signaling pathway	GO:070098	11.2	CCR6, CCL2, CCR4, CCR8, CCR5, CCR3
9	extracellular matrix disassembly	GO:022617	11.1	MMP1, MMP14, MMP2, MMP3, MMP8, MMP9
10	cellular calcium ion homeostasis	GO:006874	11.0	VDR, ATP2A2, CD40, CCL2, CCL11, CCL1
11	defense response to Gram-negative bacterium	GO:050829	10.9	SELP, SERPINE1, LBP, IL23A, IL6, CAMP
12	cell surface receptor signaling pathway	GO:007166	10.9	BDKRB2, LEPR, CD27, IL7R, MAPK14, CCL2
13	cellular response to interleukin-1	GO:071347	10.9	CHI3L1, MMP9, IL17A, IL8, CCL2, CCL3
14	negative regulation of growth of symbiont in host	GO:044130	10.9	LBP, IL10, MBL2, IFNG, CAMP, TNF
15	response to hyperoxia	GO:055093	10.8	SFTPB, SFTPC, SERPINE1, CDKN1A, MMP9, IL18
16	positive regulation of angiogenesis	GO:045766	10.8	SERPINE1, VEGFA, UTS2, CHI3L1, MMP9, FLT1
17	positive regulation of cell proliferation	GO:008284	10.8	BTC, NAMPT, VEGFA, LEP, CHRM1, AVP
18	response to mechanical stimulus	GO:009612	10.8	BGLAP, CHI3L1, JUN, MMP9, CCL2, F3
19	leukocyte migration	GO:050900	10.7	SELL, SELP, SELPLG, ITGAL, ITGAM, ITGB2
20	acute-phase response	GO:006953	10.7	SERPINA1, SERPINA3, LBP, FN1, IL1RN, IL22
21	positive regulation of chemokine production	GO:032722	10.7	LBP, IL18, IL6, TNF, HIF1A, TLR2
22	lipopolysaccharide-mediated signaling pathway	GO:031663	10.7	LBP, IL18, IL1B, MAPK14, CCL2, CCL3
23	neutrophil chemotaxis	GO:030593	10.7	PIK3CG, ITGB2, IL1B, IL8, CCL2, CCL3
24	aging	GO:007568	10.6	VDR, VCAM1, UCP3, JUN, IL1B, CCL2
25	cellular response to mechanical stimulus	GO:071260	10.6	SFTPB, SFTPC, CD40, IL13, IL18, IL1B
26	response to glucocorticoid stimulus	GO:051384	10.6	SFTPB, SFTPC, SERPINE1, BGLAP, UCP3, IL10
27	response to insulin stimulus	GO:032868	10.4	RBP4, BCL2, LEP, UCP3, IL10, CCL5
28	positive regulation of smooth muscle cell proliferation	GO:048661	10.4	JUN, FLT1, IL13, IL6, CCL5, HMOX1
29	response to radiation	GO:009314	10.4	SERPINE2, BCL2, JUN, MMP9, IL18, CCL11
30	signal transduction	GO:007165	10.3	PDE4A, NAMPT, VDR, SCGB1A1, CHRNA3, CHRM1
31	positive regulation of cell migration	GO:030335	10.3	VEGFA, MMP14, FLT1, FGF1, CCL11, CCL3
32	positive regulation of inflammatory response	GO:050729	10.3	SERPINE1, IL18, IL23A, CCL3, PTGER4, PLA2G7
33	humoral immune response	GO:006959	10.2	BCL2, CD83, IL6, CCR6, CCL2, IFNG
34	response to ethanol	GO:045471	10.2	RBP4, BGLAP, BCL2, CHAT, AVP, CD27
35	response to hypoxia	GO:001666	10.2	SFTPB, SERPINA1, VEGFA, VCAM1, UTS2, BCL2
36	response to estradiol stimulus	GO:032355	10.1	GC, SERPINA1, VDR, MMP9, IL1B, F3
37	anti-apoptosis	GO:006916	10.1	BCL2, MPO, CD27, FOXO1, GSTP1, IL10
38	positive regulation of MAP kinase activity	GO:043406	10.1	PIK3CG, VEGFA, CD40, FLT1, FGFR1, HTR2A
39	response to organic cyclic compound	GO:014070	10.1	SELP, SERPINA1, JUN, CDKN1A, CD83, IL1RN
40	cellular response to lipopolysaccharide	GO:071222	10.0	SERPINE1, LBP, GSTP1, IL10, IL8, CCL2
41	regulation of blood pressure	GO:008217	10.0	REN, UTS2, LEP, HMOX1, PTGS2, PTGS1
42	innate immune response	GO:045087	9.9	PIK3CG, SFTPD, BCL2, CHUK, LCN2, LBP
43	angiogenesis	GO:001525	9.9	PIK3CG, SERPINE1, VEGFA, JUN, MMP2, FN1
44	platelet degranulation	GO:002576	9.9	VWF, SELP, SERPINA1, SERPINE1, VEGFA, FN1
45	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	IL1B, IFNG, ICAM1, HSP90AA1, TNF, PTGS2
46	platelet activation	GO:030168	9.2	PIK3CG, VWF, SELP, SERPINA1, SERPINE1, VEGFA
47	response to drug	GO:042493	9.2	PDE4A, REN, GCLM, UTS2, BGLAP, PARK7
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.0	SERPINE1, VEGFA, VDR, MYOG, MYOD1, BMP6
49	negative regulation of apoptotic process	GO:043066	8.8	PIK3CG, BTC, SERPINE1, VEGFA, BDKRB2, BCL2
50	blood coagulation	GO:007596	8.7	PIK3CG, VWF, SELL, SELP, SELPLG, SERPINE2

Molecular functions related to chronic obstructive pulmonary disease according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	11.4	CCL3, CCL1, CCL20, CCL11, CCL2, IL8
2	receptor binding	GO:005102	11.2	ADIPOQ, IL27, MBL2, CCL2, F2, CAT
3	cytokine activity	GO:005125	10.6	IL6, IL9, IFNG, HMGB1, TNF, SPP1
4	heparin binding	GO:008201	10.4	KNG1, CTSG, FGF2, FGF1, FN1, SOD3
5	protease binding	GO:002020	9.9	SELL, TTN, ELANE, TNF, VWF, HSPA1B
6	heme binding	GO:020037	9.8	EPX, DUOX2, DUOX1, HMOX1, CYP1A2, MPO
7	growth factor activity	GO:008083	9.6	IL11, IL12A, IL10, FGF7, FGF2, FGF1
8	protein homodimerization activity	GO:042803	9.0	CAT, HSP90AA1, CCL5, IL17F, FGFR1, GSR
9	protein binding	GO:005515	8.3	SMAD3, CASP3, HSPD1, HSPA1B, HSP90AA1, HSPB1