MCID: CHR345
MIFTS: 47

Chronic Pain malady

Rare diseases, Mental diseases categories
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Summaries for Chronic Pain

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NINDS:43 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).

MalaCards based summary: Chronic Pain, also known as pain - chronic, is related to pain disorder and whiplash. An important gene associated with Chronic Pain is CACNA1B (calcium channel, voltage-dependent, N type, alpha 1B subunit), and among its related pathways are Calcium channels and CREB Pathway. The compounds quinpirole and clonidine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes, and related mouse phenotypes are homeostasis/metabolism and integument.

MedlinePlus:33 Pain is a feeling set off in the nervous system. acute pain lets you know that you may be injured or have a problem you need to take care of. chronic pain is different. the pain signals go on for weeks, months, or even years. the original cause may have been an injury or infection. there may be an ongoing cause of pain, such as arthritis or cancer. but in some cases there is no clear cause. problems that cause chronic pain include headache low back strain cancer arthritis pain from nerve damage chronic pain usually cannot be cured. but treatments can help. they include medicines, acupuncture, electrical stimulation and surgery. other treatments include psychotherapy, relaxation and meditation therapy, biofeedback, and behavior modification. nih: national institute of neurological disorders and stroke

Wikipedia:65 Chronic pain is defined as pain that has lasted longer than three to six months, though some theorists... more...

Aliases & Classifications for Chronic Pain

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Chronic Pain, Aliases & Descriptions:

Name: Chronic Pain 43 33 62
 
Pain - Chronic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Mental diseases


Related Diseases for Chronic Pain

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Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to chronic pain

Symptoms for Chronic Pain

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Drugs & Therapeutics for Chronic Pain

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Drug clinical trials:

Search ClinicalTrials for Chronic Pain

Search NIH Clinical Center for Chronic Pain

Genetic Tests for Chronic Pain

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Anatomical Context for Chronic Pain

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MalaCards organs/tissues related to Chronic Pain:

32
Spinal cord, Brain, Testes, Eye, Cortex, Heart, Breast, Cingulate cortex, Dorsal root ganglion, Kidney, Skin, Monocytes, Prefrontal cortex

Animal Models for Chronic Pain or affiliated genes

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MGI Mouse Phenotypes related to Chronic Pain:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0PENK, P2RX4, CACNA1B, PDYN, GAL
2MP:00107717.3PENK, CNR2, CACNA1B, PDYN, GAL

Publications for Chronic Pain

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Articles related to Chronic Pain:

(show top 50)    (show all 693)
idTitleAuthorsYear
1
IV. Managing chronic pain: a clinical challenge: new SIGN guidelines provide a practical evidence-based approach and identify research gaps. (24318696)
2014
2
Long-term potentiation in the anterior cingulate cortex and chronic pain. (24298148)
2014
3
Increased Pain Sensitivity in Chronic Pain Subjects on Opioid Therapy: A Cross-Sectional Study Using Quantitative Sensory Testing. (25376890)
2014
4
Ectopic endometrium-derived leptin produces estrogen-dependent chronic pain in a rat model of endometriosis. (24239717)
2014
5
The phenomenological-existential comprehension of chronic pain: going beyond the standing healthcare models. (24410937)
2014
6
Individualized Guided Internet-delivered Cognitive Behaviour Therapy for Chronic Pain Patients with Comorbid Depression and Anxiety: A Randomized Controlled Trial. (25380222)
2014
7
Factors Impacting Variability of the Urinary Normeperidine-to-Meperidine Metabolic Ratio in Patients with Chronic Pain. (24133175)
2014
8
Characteristics of sensitization associated with chronic pain conditions. (23629594)
2014
9
Acute effect of topical menthol on chronic pain in slaughterhouse workers with carpal tunnel syndrome: triple-blind, randomized placebo-controlled trial. (25298894)
2014
10
Anxiety and depression in patients with amputated limbs suffering from phantom pain: a comparative study with non-phantom chronic pain. (23543814)
2013
11
Opioids, sensory systems and chronic pain. (23500206)
2013
12
Comment on Lekpa eta88al., 'socio-demographic and clinical profile of chronic pain with neuropathic characteristics in sub-Saharan African elderly'. (23658073)
2013
13
BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. (23510079)
2013
14
The Cognitive Fusion Questionnaire: A Preliminary Study of Psychometric Properties and Prediction of Functioning in Chronic Pain. (24300218)
2013
15
FDA tightens indications for using long-acting and extended-release opioids to treat chronic pain. (24129447)
2013
16
Stress-induced allodynia--evidence of increased pain sensitivity in healthy humans and patients with chronic pain after experimentally induced psychosocial stress. (23950894)
2013
17
Chronic pain treatment: the influence of tricyclic antidepressants on serotonin release and uptake in mast cells. (23710115)
2013
18
Prevalence, causes, severity, impact, and management of chronic pain in Australian general practice patients. (23855874)
2013
19
Medical marijuana for chronic pain. (23940889)
2013
20
A trial of a brief group-based form of acceptance and commitment therapy (ACT) for chronic pain in general practice: pilot outcome and process results. (24035351)
2013
21
The chronic pain initiative and community care of North Carolina. (23940897)
2013
22
Long-term opioid therapy for chronic pain: optimizing management, minimizing risk. (23940887)
2013
23
Self-management intervention for chronic pain in older adults: a randomised controlled trial. (23522927)
2013
24
The Effects of Exercise Therapy for the Improvement of Jaw Movement and Psychological Intervention to Reduce Parafunctional Activities on Chronic Pain in the Craniocervical Region. (23656601)
2013
25
The chronic pain patient and functional assessment: use of the 6-Minute Walk Test in a multidisciplinary pain clinic. (23883277)
2013
26
Low recurrence rate and low chronic pain associated with inguinal hernia repair by laparoscopic placement of Parietex ProGripa8c mesh: clinical outcomes of 220 hernias with mean follow-up at 23 months. (23412779)
2013
27
Glia and pain: is chronic pain a gliopathy? (23792284)
2013
28
Fear of pain and movement in a patient with musculoskeletal chronic pain. (24378448)
2013
29
Effects of ozone applied by spinal endoscopy in patients with chronic pain related to failed back surgery syndrome: a pilot study. (24259984)
2013
30
The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways. (23988582)
2013
31
Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat. (23664545)
2013
32
Intravenous infusions in chronic pain management. (23703410)
2013
33
Topical analgesisc in the management of acute and chronic pain. (24141026)
2013
34
Preliminary results of the clinical effectiveness of percutaneous adhesiolysis using a Racz catheter in the management of chronic pain due to cervical central stenosis. (23877451)
2013
35
Examining the evidence about psychological treatments for chronic pain: time for a paradigm shift? (23742793)
2013
36
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. (22947198)
2012
37
A primary care-based interdisciplinary team approach to the treatment of chronic pain utilizing a pragmatic clinical trials framework. (23440672)
2012
38
Heterogeneity of chronic pain. (23389871)
2012
39
Health related quality of life and pain characteristics among Iranian patients suffering non-malignant chronic pain. (23482882)
2012
40
Are symptoms of late whiplash specific? A comparison of SCL-90-R symptom profiles of patients with late whiplash and patients with chronic pain due to other types of trauma. (21362758)
2011
41
The neural-glial purinergic receptor ensemble in chronic pain states. (19914722)
2010
42
Vitamin D for the treatment of chronic painful conditions in adults. (20091647)
2010
43
This disorder has some nerve: chronic pain in Guillain-Barre syndrome. (20861453)
2010
44
Uncoupling Src from the NMDA receptor treats chronic pain in rodents. (20408267)
2009
45
Tramadol extended-release in the management of chronic pain. (18488071)
2007
46
Sclerosing polidocanol injections to treat chronic painful shoulder impingement syndrome-results of a two-centre collaborative pilot study. (17028867)
2006
47
Pain anxiety among chronic pain patients: specific phobia or manifestation of anxiety sensitivity? (12547382)
2003
48
The demographics of chronic pain management. (12204483)
2002
49
Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note. (2520402)
1989
50
Behavior modification of abnormal gait and chronic pain secondary to somatization disorder. (3970659)
1985

Variations for Chronic Pain

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Expression for genes affiliated with Chronic Pain

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Expression patterns in normal tissues for genes affiliated with Chronic Pain

Search GEO for disease gene expression data for Chronic Pain.

Pathways for genes affiliated with Chronic Pain

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Compounds for genes affiliated with Chronic Pain

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Compounds related to Chronic Pain according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1quinpirole44 2810.9PDYN, CACNA1B
2clonidine44 50 28 1112.8GAL, CACNA1B
3damgo44 28 6111.7PENK, PDYN
4heroin44 50 1111.7PDYN, PENK
56-hydroxydopamine449.6PDYN, PENK
6anandamide61 44 28 2412.6CACNA1B, CNR2
7amphetamine44 50 1111.6GAL, PDYN
8carbachol44 28 1111.5GAL, CACNA1B
9levodopa44 1110.5PDYN, GAL
10catecholamine449.4GAL, PDYN
11capsaicin44 2810.4CACNA1B, PDYN, GAL
12atropine44 28 1111.4GAL, PDYN, CACNA1B
13kainate44 2810.4PDYN, CACNA1B, PENK
14cocaine44 1110.3PDYN, GAL
15epinephrine44 24 1111.3GAL, PDYN, CACNA1B
16nmda44 2810.3PDYN, CACNA1B, PENK
17norepinephrine44 24 1111.3CACNA1B, PDYN, GAL
18acetylcholine44 50 28 24 1113.3GAL, PDYN, CACNA1B
19potassium44 24 1111.3GAL, PDYN, CACNA1B
20naloxone44 28 50 1112.2GAL, PDYN, PENK
21pge2449.2CACNA1B, PDYN, GAL
22opiate449.2PENK, PDYN, GAL
23nicotine44 28 50 1112.2PDYN, CACNA1B
24methionine449.2GAL, PDYN, PENK
25hydrogen44 2410.0GAL, CACNA1B, CNR2
26forskolin44 50 1110.9PENK, CNR2, GAL
27atp44 289.9P2RX4, CACNA1B, PDYN, GAL
28oligonucleotide448.9GAL, PDYN, PENK
29morphine44 50 28 1111.9GAL, PDYN, CACNA1B, PENK
30gaba448.9PENK, CACNA1B, PDYN, GAL
31dopamine44 28 24 1111.8PENK, CACNA1B, PDYN, GAL
32oxygen44 249.7CNR2, P2RX4, PENK
33thymidine44 249.7PENK, CNR2, PDYN
34cyclic amp44 249.6GAL, CACNA1B, CNR2, PENK
35gtp44 289.5CNR2, CACNA1B, PDYN, GAL
36glucose448.4P2RX4, CNR2, PDYN, GAL
37adenylate448.4PENK, CNR2, PDYN, GAL
38arginine448.4GAL, PDYN, CNR2, PENK
39nitric oxide44 24 1110.4PENK, CNR2, PDYN, GAL
40tyrosine448.2GAL, PDYN, CNR2, PENK
41glutamate448.0PENK, CNR2, CACNA1B, PDYN, GAL
42calcium44 50 24 1110.6PENK, P2RX4, CNR2, CACNA1B, PDYN, GAL

GO Terms for genes affiliated with Chronic Pain

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Cellular components related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.8PDYN, CACNA1B, CNR2, P2RX4, KCNS1

Biological processes related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane depolarizationGO:0518999.7CACNA1B, P2RX4
2locomotory behaviorGO:0076269.6CACNA1B, PENK
3regulation of blood pressureGO:0082179.4CACNA1B, P2RX4
4synaptic transmissionGO:0072688.9KCNS1, CACNA1B, PDYN
5neuropeptide signaling pathwayGO:0072188.9GAL, PDYN, PENK
6sensory perception of painGO:0192338.8PENK, P2RX4, CNR2

Molecular functions related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4GAL, PENK
2opioid peptide activityGO:0015159.0PDYN, PENK

Products for genes affiliated with Chronic Pain

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  • Antibodies
  • Proteins
  • Lysates

Sources for Chronic Pain

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet