MCID: CHR345
MIFTS: 52

Chronic Pain

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Chronic Pain

MalaCards integrated aliases for Chronic Pain:

Name: Chronic Pain 50 28 40
Pain - Chronic 50

Classifications:



Summaries for Chronic Pain

NINDS : 50 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Chronic Pain, also known as pain - chronic, is related to opioid addiction and drug dependence. An important gene associated with Chronic Pain is CNR1 (Cannabinoid Receptor 1), and among its related pathways/superpathways are G-Beta Gamma Signaling and GABAergic synapse. The drugs Ethanol and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, breast and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

MedlinePlus : 40 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. They include Pain Relievers and other medicines Acupuncture Electrical stimulation Surgery Physical therapy Psychotherapy Relaxation and meditation therapy Biofeedback NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 72 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

Related Diseases for Chronic Pain

Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 opioid addiction 30.9 COMT OPRM1
2 drug dependence 29.4 CNR1 OPRM1
3 somatoform disorder 28.9 COMT OPRM1
4 post-traumatic stress disorder 28.8 CNR1 COMT
5 eating disorder 28.7 CNR1 COMT
6 alcohol dependence 28.3 CNR1 COMT OPRM1
7 chronic pain requiring intraspinal analgesia 12.0
8 paine syndrome 11.2
9 trigeminal neuralgia 11.2
10 complex regional pain syndrome 11.2
11 interstitial cystitis 11.1
12 reflex sympathetic dystrophy 10.9
13 myofascial pain syndrome 10.9
14 causalgia 10.9
15 headache 10.9
16 episodic pain syndrome, familial, 1 10.9
17 corticosteroid-binding globulin deficiency 10.7
18 occipital neuralgia 10.7
19 stiff-person syndrome 10.6
20 anterior cutaneous nerve entrapment syndrome 10.6
21 adiposis dolorosa 10.6
22 pudendal neuralgia 10.6
23 arthritis 10.6
24 brachyolmia type 3 10.6
25 exostosis 10.6
26 frozen shoulder 10.6
27 amyotrophy, hereditary neuralgic 10.6
28 polycystic kidney disease 1 10.6
29 cyclic vomiting syndrome 10.2 CNR1 OPRM1
30 leukoregulin 10.1 JUN PTGS2
31 alveolar periostitis 10.1 JUN PTGS2
32 withdrawal disorder 10.1 CNR1 OPRM1
33 morphine dependence 10.1 OPRM1 PTGS2
34 narcissistic personality disorder 10.0 JUN OPRM1
35 whiplash 10.0
36 inguinal hernia 10.0
37 opioid abuse 10.0
38 anxiety 9.9
39 polysubstance abuse 9.9 CNR1 COMT
40 pain agnosia 9.9 CNR1 OPRM1 PTGS2
41 agnosia 9.9 CNR1 OPRM1 PTGS2
42 cannabis dependence 9.9 CNR1 COMT
43 neuropathy 9.9
44 alexithymia 9.8
45 osteoarthritis 9.8
46 osteoarthritis with mild chondrodysplasia 9.8
47 neuronitis 9.8
48 aging 9.8
49 neuromuscular disease 9.8
50 neonatal abstinence syndrome 9.8 COMT OPRM1

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to Chronic Pain

Symptoms & Phenotypes for Chronic Pain

MGI Mouse Phenotypes related to Chronic Pain:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 CACNA1B CNR1 COMT DLG2 JUN OPRM1
2 homeostasis/metabolism MP:0005376 9.7 CACNA1B CNR1 COMT JUN OPRM1 P2RX4
3 integument MP:0010771 9.43 PTGS2 CACNA1B CNR1 DLG2 JUN OPRM1
4 nervous system MP:0003631 9.23 CACNA1B CNR1 COMT DLG2 JUN OPRM1

Drugs & Therapeutics for Chronic Pain

Drugs for Chronic Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 492)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
2
Norepinephrine Approved Phase 4,Phase 3,Phase 2 51-41-2 439260
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 50-02-2 5743
5
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
6
Nicotine Approved Phase 4,Phase 2 54-11-5 89594 942
7
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 1 58-22-0 6013
8
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-28-2 5757
9
Epinephrine Approved, Vet_approved Phase 4,Phase 3 51-43-4 5816
10
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1 59467-70-8 4192
11
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 57-27-2 5288826
12
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
13
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
14
Ibuprofen Approved Phase 4,Phase 3,Phase 2 15687-27-1 3672
15
Tibolone Approved, Investigational Phase 4 5630-53-5
16
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 465-65-6 5284596
17
Betamethasone Approved, Vet_approved Phase 4,Phase 2 378-44-9 9782
18
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
19
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 3007 5826
20
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
21
Capsaicin Approved Phase 4,Phase 2 404-86-4 1548943
22
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-24-8 5755
23
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 156391 1302
24
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
25
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
26
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
27
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
28
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181 3911
29
Remifentanil Approved Phase 4,Phase 3 132875-61-7 60815
30
Amitriptyline Approved Phase 4,Phase 3,Phase 2 50-48-6 2160
31
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 38396-39-3, 2180-92-9 2474
32
Citalopram Approved Phase 4 59729-33-8 2771
33
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 6740-88-1 3821
34
Methadone Approved Phase 4,Phase 3,Phase 1,Phase 2 76-99-3 4095
35
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
36
Perphenazine Approved Phase 4,Phase 3,Phase 2 58-39-9 4748
37
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2 27203-92-5 33741
38
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 76-42-6 5284603
39
Hydromorphone Approved, Illicit Phase 4,Phase 3,Phase 1 466-99-9 5284570
40
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
41
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 52485-79-7 644073 40400
42
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
43
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
44
Menthol Approved Phase 4,Phase 1,Phase 2 2216-51-5 16666
45
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 84057-95-4 175805 71273
46
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
47
Dezocine Approved, Investigational Phase 4 53648-55-8 3033053 40841
48
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 437-38-7 3345
49
Sufentanil Approved, Investigational Phase 4,Phase 3,Phase 2 56030-54-7 41693
50
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 1899)

# Name Status NCT ID Phase Drugs
1 Intraoperative Ketamine on Chronic Pain After Mastectomy Unknown status NCT02729805 Phase 4 Saline;Ketamine 0.5mg/kg;Ketamine 0.75mg/kg
2 Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain Unknown status NCT02699281 Phase 4 ultra-micronized palmitoylethanolamide;Placebo
3 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
4 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
5 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4
6 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
7 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Unknown status NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
8 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
9 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
10 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
11 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
12 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
13 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4 Remifentanil;Midazolam
14 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4 Remifentanil;Midazolam
15 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4 Midazolam;Remifentanil
16 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4 Remifentanil;Midazolam
17 Titration of Intravenous Hydromorphone Unknown status NCT01892709 Phase 4 Hydromorphone
18 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
19 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
20 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
21 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
22 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
23 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
24 Comparing Conservative Therapies for the Alleviation of Knee Pain in Knee Osteoarthritis Unknown status NCT02320500 Phase 4
25 Prolotherapy for the Treatment of Plantar Fasciitis Unknown status NCT01326351 Phase 4
26 Postoperative Pain and Angiotensin II Receptor Antagonists Unknown status NCT02513979 Phase 4 Angiotensin type II receptor antagonists
27 A Non-interventional, Observational Study for Quality of Life (Overall Health Assessment) in Patients With Chronic Severe Pain During Targinact® Treatment Unknown status NCT01710917 Phase 4 Targinact® (oxycodon/naloxon)
28 Acetaminophen for Chronic Pain in Hysterectomy Completed NCT02086747 Phase 4 Acetaminophen;Isotonic
29 Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
30 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
31 An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY) Completed NCT01811186 Phase 4 Oxycodone/naloxone
32 Pharmacokinetic Study of Hydrocodone/APAP in Chronic Pain Patients Completed NCT01517295 Phase 4 Hydrocodone
33 Impact of Tolerability Issues on Chronic Pain Completed NCT01484301 Phase 4
34 Dexamethasone and Pain Following Total Knee Arthroplasty Completed NCT02271698 Phase 4 Dexamethasone
35 Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy Completed NCT02653651 Phase 4 Ketamine;Lidocaine;Placebo
36 Chronic Pain After Amputation Completed NCT00006427 Phase 4 Amitriptyline
37 Chronic Pain in Spinal Cord Injury Completed NCT00006428 Phase 4 Amitriptyline
38 Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza Completed NCT00640042 Phase 4 morphine sulfate extended release capsules
39 Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients Completed NCT00879996 Phase 4 Methadone;Buprenorphine/naloxone
40 Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management Completed NCT02335398 Phase 4 Methadone
41 Milnacipran for Chronic Pain in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
42 A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine Completed NCT00314340 Phase 4 ER Morphine;hydrocodone plus acetaminophen;placebo
43 Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS) Completed NCT02302586 Phase 4 Thoracic paravertebral block (TPVB);Patient Controlled Analgesia (IV PCA)
44 Imaging Pain Relief in Osteoarthritis Completed NCT02208778 Phase 4 Duloxetine;Remifentanil;Placebo (for Remifentanil);Placebo (for Duloxetine)
45 Effect of Extended-release Oxymorphone Taking With or Without Food on Cognitive Functioning Completed NCT00930943 Phase 4 Oxymorphone ER (Opana ER)
46 Efficacy Study of the Octapolar Lead in Patients With Failed Back Surgery Syndrome (FBSS) With Chronic Pain Completed NCT01096147 Phase 4
47 An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Thai Participants With Chronic Non-Malignant Pain Completed NCT01816243 Phase 4 TTS-Fentanyl;Morphine
48 The Effectiveness and Tolerability of Fentanyl Matrix in Chronic Non-cancer Pain; Assessment of Patient's Pain Treatment Goal Achievement Completed NCT01688583 Phase 4 Fentanyl matrix
49 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
50 A Study to Assess the Improvement of Pain and Health-Related Quality of Life in Patients With Chronic Non-Malignant Pain Taking Tramadol Hydrochloride and Acetaminophen Completed NCT01819805 Phase 4 No intervention

Search NIH Clinical Center for Chronic Pain

Genetic Tests for Chronic Pain

Genetic tests related to Chronic Pain:

# Genetic test Affiliating Genes
1 Chronic Pain 28

Anatomical Context for Chronic Pain

MalaCards organs/tissues related to Chronic Pain:

38
Spinal Cord, Breast, Brain, Testes, Cortex, Lung, Eye

Publications for Chronic Pain

Articles related to Chronic Pain:

(show top 50) (show all 871)
# Title Authors Year
1
Chronic pain, discomfort, quality of life and impact on sex life after open inguinal hernia mesh repair: an expertise-based randomized clinical trial comparing lightweight and heavyweight mesh. ( 29353339 )
2018
2
Cumulative effects of multiple pains sites in youth with chronic pain. ( 29436161 )
2018
3
Prioritizing pediatric chronic pain and comprehensive pain treatment in the context of the opioid epidemic. ( 29451426 )
2018
4
Transcutaneous electrical nerve stimulation and interferential current demonstrate similar effects in relieving acute and chronic pain: a systematic review with meta-analysis. ( 29426587 )
2018
5
Attitudes of Irish patients with chronic pain towards medicinal cannabis. ( 29423824 )
2018
6
Clinimetric properties of the Nepali version of the Pain Catastrophizing Scale in individuals with chronic pain. ( 29430196 )
2018
7
Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome. ( 29416466 )
2018
8
Computerised training improves cognitive performance in chronic pain: a participant-blinded randomised active-controlled trial with remote supervision. ( 29447133 )
2018
9
Longitudinal resting-state fMRI in a mouse model of metastatic bone cancer reveals distinct functional reorganizations along a developing chronic pain state. ( 29319607 )
2018
10
Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial. ( 29343280 )
2018
11
Effects of Higher Versus Lower Threat Contexts on Pain-Related Visual Attention Biases: an Eye-Tracking Study of Chronic Pain. ( 29452312 )
2018
12
Identification of FAM173B as a protein methyltransferase promoting chronic pain. ( 29444090 )
2018
13
Ziconotide: Indications, Adverse Effects, and Limitations in Managing Refractory Chronic Pain. ( 29440821 )
2018
14
Depressive Disorder, Anxiety Disorder and Chronic Pain: Multiple Manifestations of a Common Clinical and Pathophysiological Core. ( 29428122 )
2018
15
Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy. ( 29105244 )
2018
16
Cognitive, emotional, and behavioral considerations for chronic pain management in the Ehlers-Danlos syndrome hypermobility-type: a narrative review. ( 29357706 )
2018
17
Barriers to the availability and accessibility of controlled medicines for chronic pain in Africa. ( 29447356 )
2018
18
Anterior insular volume decrease is associated with dysfunction of the reward system in patients with chronic pain. ( 29436061 )
2018
19
Protocol for the Individual Placement and Support (IPS) in Pain Trial: A randomized controlled trial investigating the effectiveness of IPS for patients with chronic pain. ( 29433493 )
2018
20
The impact of a short educational movie on promoting chronic pain health literacy in school: a feasibility study. ( 29436071 )
2018
21
Perceived injustice in chronic pain: an examination through the lens of predictive processing. ( 29451429 )
2018
22
Chronic pain and its association with obesity among older adults in China. ( 29427812 )
2018
23
Sleep Disturbances in Chronic Pain: Neurobiology, Assessment, and Treatment in Physical Therapist Practice. ( 29425327 )
2018
24
Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy. ( 29191644 )
2018
25
New Concepts of Chronic Pain and the Potential Role of Complementary Therapies. ( 29428928 )
2018
26
P2X receptor channels in chronic pain pathways. ( 28728214 )
2017
27
Chronic pain in refugee torture survivors. ( 29423174 )
2017
28
Prescription opioid abuse and misuse: gap between primary-care investigator assessment and actual extent of these behaviors among patients with chronic pain. ( 27782769 )
2017
29
The effect of psychological interventions on the prevention of chronic pain in adults: a systematic review protocol. ( 28934981 )
2017
30
Symptoms of chronic fatigue syndrome/myalgic encephalopathy are not determined by activity pacing when measured by the chronic pain coping inventory. ( 28843450 )
2017
31
Literature Review of Research on Chronic Pain and Yoga in Military Populations. ( 28930278 )
2017
32
Opioids in chronic pain - Primum non nocere. ( 28950245 )
2017
33
Chronic Pain-Related Changes in Cardiovascular Regulation and Impact on Comorbid Hypertension in a General Population: The TromsA, Study. ( 28953193 )
2017
34
Treatment of chronic pain associated with bruxism through Myofunctional therapy. ( 29118958 )
2017
35
Developing a typology of patient-generated behavioral goals for cognitive behavioral therapy for chronic pain (CBT-CP): classification and predicting outcomes. ( 28936717 )
2017
36
Management of chronic pain through pain management programmes. ( 28927228 )
2017
37
Repetitive Transcranial Magnetic Stimulation in Chronic Pain: A Meta-analysis. ( 28928582 )
2017
38
Joint Hypermobility Syndrome: Recognizing a Commonly Overlooked Cause of Chronic Pain. ( 28286166 )
2017
39
Prescription Opioid Abuse in Chronic Pain: An Updated Review of Opioid Abuse Predictors and Strategies to Curb Opioid Abuse (Part 2). ( 28226334 )
2017
40
The grimace scale reliably assesses chronic pain in a rodent model of trigeminal neuropathic pain. ( 29450305 )
2017
41
Dynamic daily associations between insomnia symptoms and alcohol use in adults with chronic pain. ( 28940629 )
2017
42
Understanding the different relationships between mood and sleep disorders in several groups of non-oncological patients with chronic pain. ( 28945136 )
2017
43
Factors Contributing to Depression and Chronic Pain in Patients with Hidradenitis Suppurativa: Results from a Single-Center Retrospective Review. ( 28068657 )
2017
44
Whiplash Injury: Perspectives on the Development of Chronic Pain. ( 28759489 )
2017
45
Prescription Opioid Abuse in Chronic Pain: An Updated Review of Opioid Abuse Predictors and Strategies to Curb Opioid Abuse: Part 1. ( 28226333 )
2017
46
Src-family kinases activation in spinal microglia contributes to central sensitization and chronic pain after lumbar disc herniation. ( 28952414 )
2017
47
The triallelic serotonin transporter gene polymorphism is associated with depressive symptoms in adults with chronic pain. ( 28533695 )
2017
48
Activation of KCNQ channels suppresses spontaneous activity in DRG neurons and reduces chronic pain after spinal cord injury. ( 28073317 )
2017
49
Predictors of chronic pain following total knee replacement in females and males: an exploratory study. ( 28936909 )
2017
50
A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models. ( 28927787 )
2017

Variations for Chronic Pain

Expression for Chronic Pain

Search GEO for disease gene expression data for Chronic Pain.

Pathways for Chronic Pain

GO Terms for Chronic Pain

Cellular components related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.26 CACNA1B COMT OPRM1 P2RX4
2 postsynapse GO:0098794 9.16 OPRM1 P2RX4
3 axon GO:0030424 9.02 CNR1 COMT DLG2 OPRM1 P2RX4

Biological processes related to Chronic Pain according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.78 CNR1 JUN PTGS2
2 response to drug GO:0042493 9.76 COMT JUN PTGS2
3 chemical synaptic transmission GO:0007268 9.72 CACNA1B DLG2 OPRM1
4 aging GO:0007568 9.69 CNR1 JUN PTGS2
5 calcium ion transmembrane transport GO:0070588 9.65 CACNA1B OPRM1 P2RX4
6 response to organic cyclic compound GO:0014070 9.63 COMT JUN PTGS2
7 memory GO:0007613 9.61 CNR1 PTGS2
8 response to cytokine GO:0034097 9.6 JUN PTGS2
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.59 JUN PTGS2
10 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.58 CNR1 OPRM1
11 regulation of blood pressure GO:0008217 9.58 CACNA1B P2RX4 PTGS2
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.57 P2RX4 PTGS2
13 response to cocaine GO:0042220 9.56 CNR1 OPRM1
14 response to morphine GO:0043278 9.54 CNR1 OPRM1
15 regulation of sensory perception of pain GO:0051930 9.52 COMT OPRM1
16 learning GO:0007612 9.5 COMT JUN PTGS2
17 response to pain GO:0048265 9.49 CACNA1B COMT
18 cellular response to ATP GO:0071318 9.43 P2RX4 PTGS2
19 response to radiation GO:0009314 9.43 JUN OPRM1 PTGS2
20 positive regulation of fever generation GO:0031622 9.37 CNR1 PTGS2
21 response to lipopolysaccharide GO:0032496 9.35 CNR1 COMT JUN OPRM1 PTGS2
22 membrane depolarization GO:0051899 9.33 CACNA1B JUN P2RX4
23 sensory perception of pain GO:0019233 9.02 CNR1 DLG2 OPRM1 P2RX4 PTGS2

Molecular functions related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated calcium channel activity GO:0005245 8.62 CACNA1B OPRM1

Sources for Chronic Pain

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....