MCID: CHR345
MIFTS: 50

Chronic Pain malady

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Chronic Pain

Aliases & Descriptions for Chronic Pain:

Name: Chronic Pain 51 41
Pain - Chronic 51 29

Classifications:



Summaries for Chronic Pain

NINDS : 51 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Chronic Pain, also known as pain - chronic, is related to cervicitis and chronic pain requiring intraspinal analgesia. An important gene associated with Chronic Pain is PTGS2 (Prostaglandin-Endoperoxide Synthase 2), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and GABAergic synapse. The drugs Ethanol and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes, and related phenotypes are behavior/neurological and cardiovascular system

MedlinePlus : 41 pain is a feeling set off in the nervous system. acute pain lets you know that you may be injured or have a problem you need to take care of. chronic pain is different. the pain signals go on for weeks, months, or even years. the original cause may have been an injury or infection. there may be an ongoing cause of pain, such as arthritis or cancer. but in some cases there is no clear cause. problems that cause chronic pain include headache low back strain cancer arthritis pain from nerve damage chronic pain usually cannot be cured. but treatments can help. they include medicines, acupuncture, electrical stimulation and surgery. other treatments include psychotherapy, relaxation and meditation therapy, biofeedback, and behavior modification. nih: national institute of neurological disorders and stroke

Wikipedia : 71 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

Related Diseases for Chronic Pain

Diseases in the Chronic Pain family:

Pain Disorder Central Pain Syndrome

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
id Related Disease Score Top Affiliating Genes
1 cervicitis 29.6 OPRM1 PTGS2
2 chronic pain requiring intraspinal analgesia 11.9
3 pain disorder 11.2
4 trigeminal neuralgia 11.1
5 complex regional pain syndrome 11.0
6 ehlers-danlos syndrome 10.8
7 interstitial cystitis 10.8
8 myofascial pain syndrome 10.8
9 occipital neuralgia 10.6
10 corticosteroid-binding globulin deficiency 10.6
11 polycystic kidney disease, adult type i 10.5
12 frozen shoulder 10.5
13 amyotrophy, hereditary neuralgic 10.5
14 pudendal neuralgia 10.5
15 stiff-person syndrome 10.5
16 adiposis dolorosa 10.5
17 exostosis 10.5
18 osteoporosis 10.5
19 anterior cutaneous nerve entrapment syndrome 10.5
20 vaginal carcinosarcoma 10.1 JUN PTGS2
21 cervical carcinosarcoma 10.1 OPRM1 PTGS2
22 mycobacterium avium complex disease 10.0 JUN OPRM1
23 peripheral vertigo 10.0 COMT OPRM1
24 c8 deficiency, type ii 10.0 COMT OPRM1
25 simultanagnosia 9.9 OPRM1 PTGS2
26 testicular leydig cell tumor 9.9 COMT OPRM1
27 inguinal hernia 9.9
28 whiplash 9.8
29 opioid abuse 9.8
30 osteoarthritis 9.7
31 neuropathy 9.7
32 alexithymia 9.7
33 neuronitis 9.7
34 neuromuscular disease 9.7
35 spinal cord injury 9.7
36 back pain 9.6
37 reflex sympathetic dystrophy 9.6
38 post-traumatic stress disorder 9.6
39 drug dependence 9.6
40 sickle cell disease 9.6
41 diabetic neuropathy 9.6
42 personality disorder 9.6
43 cystitis 9.6
44 hypogonadism 9.6
45 breast cancer 9.6
46 tendinopathy 9.6
47 somatoform disorder 9.6
48 calcific tendinitis 9.5
49 serotonin syndrome 9.5
50 multiple personality disorder 9.5

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to Chronic Pain

Symptoms & Phenotypes for Chronic Pain

MGI Mouse Phenotypes related to Chronic Pain:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.98 CACNA1B OPRM1 COMT DLG2 PTGS2 EGR1
2 cardiovascular system MP:0005385 9.88 JUN CACNA1B COMT P2RX4 PTGS2 EGR1
3 endocrine/exocrine gland MP:0005379 9.85 CACNA1B OPRM1 COMT PTGS2 EGR1 JUN
4 hematopoietic system MP:0005397 9.8 JUN OPRM1 COMT P2RX4 PTGS2 EGR1
5 homeostasis/metabolism MP:0005376 9.8 JUN CACNA1B OPRM1 COMT P2RX4 PTGS2
6 immune system MP:0005387 9.63 JUN OPRM1 COMT P2RX4 PTGS2 EGR1
7 integument MP:0010771 9.43 CACNA1B OPRM1 DLG2 PTGS2 EGR1 JUN
8 nervous system MP:0003631 9.23 CACNA1B OPRM1 COMT P2RX4 DLG2 PTGS2

Drugs & Therapeutics for Chronic Pain

Drugs for Chronic Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1002)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Early Phase 1 64-17-5 702
2
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
5
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
6
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
7
Baclofen Approved Phase 4,Phase 3,Phase 1,Phase 2 1134-47-0 2284
8
Nicotine Approved Phase 4,Phase 2 54-11-5 942 89594
9
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
10
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-22-0 6013
11
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-78-2 2244
12
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-28-2 5757 53477783
13
Fexofenadine Approved Phase 4 83799-24-0 3348
14
Epinephrine Approved, Vet_approved Phase 4,Phase 3 51-43-4 5816
15
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1 59467-70-8 4192
16
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
17
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
18
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 57-27-2 5288826
19
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
20
Ibuprofen Approved Phase 4,Phase 3,Phase 2 15687-27-1 3672
21
Nicorandil Approved Phase 4 65141-46-0 47528
22
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
23
Ramipril Approved Phase 4,Early Phase 1 87333-19-5 5362129
24
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
25
Atenolol Approved Phase 4,Phase 2 29122-68-7 2249
26
Carvedilol Approved, Investigational Phase 4,Phase 1 72956-09-3 2585
27
Metoprolol Approved, Investigational Phase 4,Phase 1,Early Phase 1 37350-58-6, 51384-51-1 4171
28
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
29
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 2 55-63-0 4510
30
Galantamine Approved Phase 4 357-70-0 9651 908828, 9651
31
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
32
Memantine Approved, Investigational Phase 4,Phase 3 19982-08-2 4054
33
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 75614-87-8, 51-45-6 774
34
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
35
Sumatriptan Approved, Investigational Phase 4,Phase 2 103628-46-2 5358
36
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 465-65-6 5284596
37
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 378-44-9 9782
38
Topiramate Approved Phase 4,Phase 3 97240-79-4 5284627
39
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2 58-61-7 60961
40
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
41
Amphetamine Approved, Illicit Phase 4,Phase 1 300-62-9 5826 3007
42
Capsaicin Approved Phase 4,Phase 2,Phase 1 404-86-4 1548943
43
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
44
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
45
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
46
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
47
Desogestrel Approved Phase 4 54024-22-5 40973
48
Levonorgestrel Approved, Investigational Phase 4,Phase 2 797-63-7, 17489-40-6 13109
49
Flurbiprofen Approved, Investigational Phase 4,Phase 2 5104-49-4 3394
50
Remifentanil Approved Phase 4,Phase 3 132875-61-7 60815

Interventional clinical trials:

(show top 50) (show all 4463)
id Name Status NCT ID Phase
1 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
2 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4
3 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4
4 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
5 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Unknown status NCT02289261 Phase 4
6 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4
7 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
8 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4
9 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4
10 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4
11 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4
12 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4
13 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4
14 Titration of Intravenous Hydromorphone Unknown status NCT01892709 Phase 4
15 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4
16 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT02279628 Phase 4
17 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
18 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4
19 Prolotherapy for the Treatment of Plantar Fasciitis Unknown status NCT01326351 Phase 4
20 A Non-interventional, Observational Study for Quality of Life (Overall Health Assessment) in Patients With Chronic Severe Pain During Targinact® Treatment Unknown status NCT01710917 Phase 4
21 Effect of Three Therapeutics Strategies on Patients With a Chronic Back Pain (PLURICLEF). Unknown status NCT02030171 Phase 4
22 Botulinum Toxin A for the Treatment of Chronic Lumbar Back Pain Unknown status NCT00404417 Phase 4
23 Therapeutic Effects of Video Game Play Therapy on Patients With Chronic Low Back Pain Unknown status NCT02125968 Phase 4
24 Double-Blind Placebo Study on Magnetic Field Therapy in Chronic Lumbar Pain Unknown status NCT00407615 Phase 4
25 Therapeutic Effects of Monochromatic Infrared Energy Therapy on Patients With Chronic Low Back Pain Unknown status NCT01920971 Phase 4
26 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4
27 Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain Unknown status NCT00444990 Phase 4
28 Evaluation of the Efficacy and Tolerability of Etoricoxib Monotherapy Versus Combination Oxycodone-etoricoxib in Moderate to Severe Pain From Chronic Low Back Pain Unknown status NCT01344720 Phase 4
29 Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain Unknown status NCT00445133 Phase 4
30 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
31 A Pilot Study Comparing the Analgesic Efficacy of IV Ibuprofen and IV Ketorolac Unknown status NCT01514175 Phase 4
32 Single Shot Intrathecal Ziconotide for Painful Neuropathy or Myelopathy Unknown status NCT01992562 Phase 4
33 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4
34 The Effect of Ketamine Infusion on Lumbar Surgery Unknown status NCT02154438 Phase 4
35 Preventing Pain After Heart Surgery Unknown status NCT01480765 Phase 4
36 Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Unknown status NCT02060305 Phase 4
37 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4
38 Comparative Study on Self-adhesive Mesh for Open Inguinal Hernia Repair Unknown status NCT00960011 Phase 4
39 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4
40 Galantamine in the Treatment of Post-Traumatic Headache Unknown status NCT00219869 Phase 4
41 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Unknown status NCT02480647 Phase 4
42 Efficacy and Safety Study of Guanxin Shutong Capsule to Treat Chronic Stable Angina Unknown status NCT02280850 Phase 4
43 Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy Unknown status NCT00466544 Phase 4
44 Sodium Oxybate in Patients With Chronic Fatigue Syndrome. Unknown status NCT01584934 Phase 4
45 The Effect on an Ionic Silver Dressing in Head and Neck Patients With Malignant Fungating Wound Unknown status NCT00813631 Phase 4
46 Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina Unknown status NCT00131183 Phase 4
47 Ultrasound TFP (Transversalis Fascia Plane) for Analgesia After Iliac Crest Bone Graft Harvest Unknown status NCT02398474 Phase 4
48 Lactobacillus Reuteri in Children With Constipation Unknown status NCT01388712 Phase 4
49 Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina. Unknown status NCT01397994 Phase 4
50 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4

Search NIH Clinical Center for Chronic Pain

Genetic Tests for Chronic Pain

Genetic tests related to Chronic Pain:

id Genetic test Affiliating Genes
1 Chronic Pain 29

Anatomical Context for Chronic Pain

MalaCards organs/tissues related to Chronic Pain:

39
Spinal Cord, Brain, Testes, Breast, Cortex, Eye, Heart

Publications for Chronic Pain

Articles related to Chronic Pain:

(show top 50) (show all 810)
id Title Authors Year
1
Factors Contributing to Depression and Chronic Pain in Patients with Hidradenitis Suppurativa: Results from a Single-Center Retrospective Review. ( 28068657 )
2017
2
Activation of KCNQ channels suppresses spontaneous activity in DRG neurons and reduces chronic pain after spinal cord injury. ( 28073317 )
2017
3
A novel inhibitor of endocannabinoid catabolic enzymes sheds light on behind the scene interplay between chronic pain, analgesic tolerance, and heroin dependence. ( 27890603 )
2017
4
Prescription opioid abuse and misuse: gap between primary-care investigator assessment and actual extent of these behaviors among patients with chronic pain. ( 27782769 )
2017
5
Chronic Pain Without Clear Etiology in Low- and Middle-Income Countries: A Narrative Review. ( 27195643 )
2016
6
A Brain Signature to Differentiate Acute and Chronic Pain in Rats. ( 27199727 )
2016
7
The association between a history of lifetime traumatic events and pain severity, physical function, and affective distress in patients with chronic pain. ( 27641311 )
2016
8
The Influence of Type of Anesthesia, Perioperative Pain, and Preoperative Health Status on Chronic Pain Six Months After Thoracotomy-A Prospective Cohort Study. ( 27651509 )
2016
9
Current experience of spinal neuromodulation in chronic pain: Is there a role in children and young people? ( 27658771 )
2016
10
Two heterozygous Cav3.2 channel mutations in a pediatric chronic pain patient: recording condition-dependent biophysical effects. ( 26706850 )
2016
11
Suicidal ideation is associated with individual differences in prescription opioid craving and cue-reactivity among chronic pain patients. ( 27644963 )
2016
12
Mindfulness Meditation for Chronic Pain: Systematic Review and Meta-analysis. ( 27658913 )
2016
13
The epidemiology of chronic pain. ( 27643833 )
2016
14
Estimating the Risk of Chronic Pain: Development and Validation of a Prognostic Model (PICKUP) for Patients with Acute Low Back Pain. ( 27187782 )
2016
15
Quantifying dimensions of physical behavior in chronic pain conditions. ( 27663524 )
2016
16
Compounded Topical Analgesics for Chronic Pain. ( 27649348 )
2016
17
Rewiring of Developing Spinal Nociceptive Circuits by Neonatal Injury and Its Implications for Pediatric Chronic Pain. ( 27657152 )
2016
18
Incidence and severity of chronic pain after caesarean section: A systematic review with meta-analysis. ( 27635953 )
2016
19
Alexithymia in Chronic Pain Disorders. ( 27215759 )
2016
20
Pain in the body. Altered interoception in chronic pain conditions: A systematic review. ( 27654341 )
2016
21
Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. ( 27658292 )
2016
22
Using Chronic Pain Outcomes Data to Improve Outcomes. ( 27208717 )
2016
23
Involvement of the nucleus accumbens and dopamine system in chronic pain. ( 27655737 )
2016
24
Seizures associated with low-dose tramadol for chronic pain treatment. ( 27212778 )
2016
25
Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery: A Prospective, Double-Blind, and Randomized Trial. ( 27196485 )
2016
26
Chronic Pain and Its Treatment in an Era of Increased Scrutiny. ( 27208719 )
2016
27
Comment on Deckert et al.: A systematic review of the outcomes reported in multimodal pain therapy for chronic pain. ( 27633811 )
2016
28
Pain Reduction and Repeat Injections After Transforaminal Epidural Injection With Particulate Versus Nonparticulate SteroidA for the Treatment of Chronic Painful LumbosacralA Radiculopathy. ( 27060648 )
2016
29
Cognitive deficits in chronic pain patients, in a brief screening test, are independent of comorbidities and medication use. ( 27191230 )
2016
30
Opioids and chronic pain. Data from the "other side of the pond". ( 27647466 )
2016
31
Comparative effectiveness of percutaneous epidural adhesiolysis for different sacrum types in patients with chronic pain due to lumbar disc herniation: A propensity score matching analysis. ( 27631213 )
2016
32
Opioid Overdose History, Risk Behaviors, and Knowledge in Patients Taking Prescribed Opioids for Chronic Pain. ( 27651504 )
2016
33
Announcing the CDC guideline for prescribing opioids for chronic pain. ( 27178083 )
2016
34
Chronic Pain Types Differ in Their Reported Prevalence of Post -Traumatic Stress Disorder (PTSD) and There Is Consistent Evidence That Chronic Pain Is Associated with PTSD: An Evidence-Based Structured Systematic Review. ( 27188666 )
2016
35
Uniformity of Chronic Pain Assessment after Inguinal Hernia Repair: A Critical Review of the Literature. ( 27577699 )
2016
36
Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies. ( 27028915 )
2016
37
Acute and Chronic Pain on the Battlefield: Lessons Learned from Point of Injury to the United States. ( 27215875 )
2016
38
Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications and bladder hydrodistension: A case report. ( 27930554 )
2016
39
Can Chronic Pain Be Prevented? ( 27208712 )
2016
40
Corticolimbic anatomical characteristics predetermine risk for chronic pain. ( 27190016 )
2016
41
The role of alexithymia: An 8-year follow-up study of chronic pain patients. ( 27423355 )
2016
42
Chronic pain disrupts the reward circuitry in multiple sclerosis. ( 27178661 )
2016
43
Chronic Pain and the Opioid Conundrum. ( 27208714 )
2016
44
Easily Administered Patient Reported Outcome Measures: Adolescents' Perceived Functional Changes after Completing an Intensive Chronic Pain Rehabilitation Program. ( 27639440 )
2016
45
CRHBP polymorphisms predict chronic pain development following motor vehicle collision. ( 26447706 )
2016
46
Chronic pain and cognition. ( 27191229 )
2016
47
Chronic pain along the lateral condyle of humerus. ( 27652369 )
2016
48
Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain. ( 27184839 )
2016
49
Assessing and Managing Sleep Disturbance in Patients with Chronic Pain. ( 27208716 )
2016
50
Overlapping Mechanisms of Stress-Induced Relapse to Opioid Use Disorder and Chronic Pain: Clinical Implications. ( 27199787 )
2016

Variations for Chronic Pain

Expression for Chronic Pain

Search GEO for disease gene expression data for Chronic Pain.

Pathways for Chronic Pain

Pathways related to Chronic Pain according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 EGR1 JUN PTGS2
2
Show member pathways
12.12 CACNA1B OPRM1 PTGS2
3 11.61 COMT DLG2 EGR1 OPRM1 P2RX4 PTGS2
4 11.36 EGR1 JUN
5
Show member pathways
11.35 EGR1 JUN
6
Show member pathways
11.31 JUN PTGS2
7
Show member pathways
11.28 EGR1 JUN
8 11.24 CACNA1B PTGS2
9 11.11 JUN PTGS2
10 11.07 EGR1 JUN
11
Show member pathways
11.01 EGR1 JUN PTGS2
12 10.8 JUN PTGS2
13 10.36 JUN PTGS2

GO Terms for Chronic Pain

Cellular components related to Chronic Pain according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.26 CACNA1B COMT OPRM1 P2RX4
2 postsynapse GO:0098794 9.16 OPRM1 P2RX4
3 axon GO:0030424 8.92 COMT DLG2 OPRM1 P2RX4

Biological processes related to Chronic Pain according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.71 COMT JUN PTGS2
2 chemical synaptic transmission GO:0007268 9.69 CACNA1B DLG2 OPRM1
3 response to organic cyclic compound GO:0014070 9.61 COMT JUN PTGS2
4 response to cytokine GO:0034097 9.56 JUN PTGS2
5 response to lipopolysaccharide GO:0032496 9.56 COMT JUN OPRM1 PTGS2
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.55 JUN PTGS2
7 regulation of blood pressure GO:0008217 9.54 CACNA1B P2RX4 PTGS2
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.52 P2RX4 PTGS2
9 learning GO:0007612 9.5 COMT JUN PTGS2
10 regulation of sensory perception of pain GO:0051930 9.49 COMT OPRM1
11 response to pain GO:0048265 9.48 CACNA1B COMT
12 estrous cycle GO:0044849 9.46 EGR1 OPRM1
13 cellular response to ATP GO:0071318 9.4 P2RX4 PTGS2
14 response to radiation GO:0009314 9.33 JUN OPRM1 PTGS2
15 membrane depolarization GO:0051899 9.13 CACNA1B JUN P2RX4
16 sensory perception of pain GO:0019233 8.92 DLG2 OPRM1 P2RX4 PTGS2

Molecular functions related to Chronic Pain according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated calcium channel activity GO:0005245 8.96 CACNA1B OPRM1
2 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000982 8.62 EGR1 JUN

Sources for Chronic Pain

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38