MCID: CHR345
MIFTS: 36

Chronic Pain malady

Summaries for Chronic Pain

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Sources:
33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).

MalaCards: Chronic Pain, also known as pain - chronic, is related to pain disorder and drug dependence. An important gene associated with Chronic Pain is CACNA1B (calcium channel, voltage-dependent, N type, alpha 1B subunit), and among its related pathways are Regulation of thyroid hormone activity and Tyrosine metabolism p.1 (dopamine) . The compounds estrogen and heroin have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and integument.

MedlinePlus:33 Pain is a feeling set off in the nervous system. acute pain lets you know that you may be injured or have a problem you need to take care of. chronic pain is different. the pain signals go on for weeks, months, or even years. the original cause may have been an injury or infection. there may be an ongoing cause of pain, such as arthritis or cancer. but in some cases there is no clear cause. problems that cause chronic pain include headache low back strain cancer arthritis pain from nerve damage chronic pain usually cannot be cured. but treatments can help. they include medicines, acupuncture, electrical stimulation and surgery. other treatments include psychotherapy, relaxation and meditation therapy, biofeedback, and behavior modification. nih: national institute of neurological disorders and stroke

Wikipedia:63 Chronic pain is defined as pain that has lasted longer than three to six months, though some theorists... more...

Aliases & Classifications for Chronic Pain

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Sources:
43NINDS, 33MedlinePlus, 60UMLS
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Aliases & Descriptions:

chronic pain 43 33 60
pain - chronic 43


Related Diseases for Chronic Pain

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pain Disorder family:

chronic pain

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1pain disorder30.9GAL, PNOC
2drug dependence30.2PNOC, PDYN
3multiple sclerosis30.0COMT, CNR2
4cystitis30.0TACR1
5pancreatitis29.7TACR1
6obsessive-compulsive disorder29.7PDYN, COMT, TTF2
7opioid abuse10.3
8neuromuscular disease10.2
9neuropathy10.2
10osteoarthritis10.2
11neuronitis10.2
12complex regional pain syndrome10.2
13reflex sympathetic dystrophy10.1
14somatization disorder10.1
15alexithymia10.1
16trigeminal neuralgia10.1
17cervicitis10.1
18chronic cervicitis10.1
19myofascial pain syndrome10.1
20alcohol dependence10.1
21ehlers-danlos syndrome10.1
22peripheral neuropathy10.1
23personality disorder10.1
24somatoform disorder10.1
25sickle cell disease10.1
26tendinitis10.0
27tendinosis10.0
28major depressive disorder10.0
29chronic interstitial cystitis10.0
30causalgia10.0
31multiple personality disorder10.0
32post-traumatic stress disorder10.0
33chronic fatigue syndrome10.0
34calcific tendinitis10.0
35breast cancer10.0
36chronic cystitis10.0
37diabetic neuropathy10.0
38hypogonadism10.0
39mononeuropathy10.0
40muscular dystrophy10.0
41myotonic dystrophy10.0
42obesity10.0
43sleep disorder10.0
44spinal cord disease10.0
45substance dependence10.0
46ehlers-danlos syndrome, hypermobility type10.0
47occipital neuralgia10.0
48chronic pain requiring intraspinal analgesia10.0
49hypertension10.0DBH
50bulimia nervosa10.0COMT

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to chronic pain

Clinical Features for Chronic Pain

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Drugs & Therapeutics for Chronic Pain

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chronic Pain

Drug clinical trials:

Search ClinicalTrials for Chronic Pain

Search NIH Clinical Center for Chronic Pain

Highlights from CenterWatch's Drugs in Clinical Trials Database for Chronic Pain:

idCompanyCompoundMechanismPhase
1Nektar TherapeuticsNKTR-181A next-generation mu-opioid analgesicII

Genetic Tests for Chronic Pain

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Anatomical Context for Chronic Pain

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Animal Models for Chronic Pain or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Chronic Pain:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.4BDKRB1, CACNA1B, CHAT, DBH, TACR1, P2RX4
2MP:00107719.1BDKRB1, CACNA1B, PDYN, GAL, DBH, CNR2
3MP:00053869.0PENK, COMT, BDKRB1, CACNA1B, PDYN, GAL
4MP:00036318.7COMT, CACNA1B, PDYN, GAL, CHAT, GRM2
5MP:00053768.7CHAT, GAL, PDYN, CACNA1B, BDKRB1, COMT

Publications for Chronic Pain

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Genetic Variations for Chronic Pain

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Expression for genes affiliated with Chronic Pain

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Pain

Search GEO for disease gene expression data for Chronic Pain.

Pathways for genes affiliated with Chronic Pain

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 51QIAGEN, 29KEGG
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Pathways related to Chronic Pain according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3DBH, CHAT
2
Tyrosine metabolism p.1 (dopamine)
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10.2DBH, COMT
310.2P2RX3, P2RX4, CACNA1B
410.2CACNA1B, CHAT, SLC18A3
510.1TACR1, BTG2, PDYN
6
Hide members
10.0COMT, KCNS1, CACNA1B, CHAT, SLC18A3
7
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9.9TACR1, GAL, NPFF, BDKRB1
8
Hide members
9.9CACNA1B, GRM2, P2RX4, P2RX3, PENK
9
Hide members
9.9BDKRB1, NPFF, TACR1, ADRBK1
109.9BDKRB1, CACNA1B, TACR1, P2RX4, P2RX3
119.8PDYN, GAL, CHAT, PNOC, SLC18A3, PENK
12
Hide members
9.8COMT, CACNA1B, CHAT, GRM2, SLC18A3, ADRBK1
13
Hide members
9.2BDKRB1, PDYN, NPFF, GAL, GRM2, CNR2
14
Hide members
9.1PENK, BDKRB1, PDYN, NPFF, GAL, GRM2

Compounds for genes affiliated with Chronic Pain

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Chronic Pain according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5PDYN, PNOC, CHAT
2heroin44 49 1112.4COMT, PDYN, CHAT, PENK
3dpdpe28 44 5912.4PDYN, PNOC, TACR1
4npff4410.4PDYN, PNOC, NPFF
5(+-)vesamicol4410.4SLC18A3, CHAT
6homovanillic acid44 2411.3COMT, CHAT, DBH
7etorphine44 28 1112.3ADRBK1, PNOC, PDYN
86-hydroxydopamine4410.3PENK, DBH, CHAT, PDYN, COMT
9naloxone44 49 28 1113.3PENK, GAL, PDYN, PNOC
10clonidine44 28 1112.3CACNA1B, GAL, DBH, TACR1
11atropine44 28 1112.3PNOC, PDYN, GAL, CACNA1B, TACR1
12damgo44 59 2812.3ADRBK1, PENK, PNOC, TACR1, PDYN
13nicotine44 49 28 1113.2CACNA1B, CHAT, COMT, PDYN, DBH, TTF2
14levodopa44 1111.2GAL, PDYN, DBH, COMT
15kainate44 2811.2CACNA1B, PENK, GRM2, CHAT, TACR1, PDYN
16catecholamine4410.2COMT, PDYN, CHAT, DBH, ADRBK1, GAL
17forskolin44 49 1112.2CHAT, GAL, PENK, PNOC, GRM2, DBH
18capsaicin44 2811.2PDYN, CACNA1B, GAL, TACR1, P2RX3, PNOC
19amine4410.2COMT, CHAT, DBH, SLC18A3
20l-amino acid4410.1DBH, CHAT, COMT
21hydrogen44 2411.1SLC18A3, TTF2, COMT, CNR2, DBH, GAL
22choline44 11 2412.1DBH, TACR1, SLC18A3, CHAT, GAL, COMT
23epinephrine44 11 2412.1DBH, GAL, PDYN, CACNA1B, ADRBK1, COMT
24cocaine44 1111.1COMT, PDYN, CHAT, DBH, SLC18A3, PNOC
25lead4410.0TTF2, DBH, ADRBK1, NPFF
26gtp44 2811.0PNOC, TTF2, CACNA1B, PDYN, GAL, CNR2
27ethanol44 49 11 2413.0TACR1, PDYN, CHAT, DBH, TTF2, P2RX3
285-hydroxytryptamine4410.0PNOC, TACR1, DBH, CHAT, GAL, COMT
29pge24410.0CACNA1B, PDYN, GAL, DBH, TACR1, PNOC
30adenylate4410.0DBH, GAL, CNR2, PDYN, TACR1, PNOC
31opiate449.9PENK, PDYN, TACR1, NPFF, GAL, DBH
32nmda44 2810.9TACR1, CACNA1B, CHAT, ADRBK1, COMT, PDYN
33gaba449.9CHAT, ADRBK1, PENK, PNOC, DBH, GRM2
34norepinephrine44 11 2411.8PDYN, GAL, CHAT, COMT, DBH, TACR1
35atp44 2810.8CHAT, P2RX4, TTF2, GAL, P2RX3, CACNA1B
36alanine449.8GAL, CACNA1B, TACR1, PNOC, TTF2, DBH
37sodium44 2410.8CHAT, GAL, CACNA1B, TTF2, DBH, PNOC
38glucose449.8TACR1, P2RX4, CNR2, DBH, CHAT, GAL
39morphine44 49 28 1112.7PDYN, NPFF, GAL, DBH, PNOC, ADRBK1
40cysteine449.7DBH, CACNA1B, COMT, PDYN, PENK, SLC18A3
41acetylcholine44 49 28 11 2413.7DBH, CACNA1B, ADRBK1, SLC18A3, PNOC, P2RX3
42lipid449.7PNOC, GAL, CNR2, PDYN, DBH, CHAT
43progesterone44 59 28 11 2413.7PDYN, CHAT, TACR1, TTF2, PNOC, PENK
44cyclic amp44 2410.6CACNA1B, NPFF, GAL, ADRBK1, CHAT, GRM2
45tyrosine449.5DBH, CHAT, SLC18A3, GRM2, GAL, PENK
46histamine44 28 2411.5ADRBK1, PNOC, TACR1, GAL, DBH
47dopamine44 28 11 2412.5ADRBK1, COMT, CACNA1B, PDYN, GAL, CHAT
48nitric oxide44 11 2411.5P2RX3, TACR1, CNR2, DBH, CHAT, GAL
49glutamate449.4COMT, CACNA1B, PDYN, GAL, SLC18A3, CHAT
50calcium44 49 11 2412.0DBH, GRM2, CHAT, GAL, NPFF, CNR2

GO Terms for genes affiliated with Chronic Pain

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Sources:
16Gene Ontology
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Cellular components related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.8TACR1, CNR2, GRM2, NPFF, CACNA1B
2integral to plasma membraneGO:0058879.3BDKRB1, GRM2, CNR2, TACR1, P2RX4, P2RX3
3plasma membraneGO:0058869.2KCNS1, BDKRB1, CACNA1B, PDYN, GRM2, CNR2

Biological processes related to Chronic Pain according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.6COMT, DBH
2purinergic nucleotide receptor signaling pathwayGO:03559010.5P2RX3, P2RX4
3positive regulation of calcium ion transport into cytosolGO:01052410.5P2RX3, P2RX4
4response to painGO:04826510.5DBH, CACNA1B, COMT
5neurotransmitter secretionGO:00726910.5SLC18A3, CHAT, CACNA1B
6tachykinin receptor signaling pathwayGO:00721710.5TACR1, ADRBK1
7positive regulation of leukocyte migrationGO:00268710.4TACR1, BDKRB1
8neurotransmitter biosynthetic processGO:04213610.4COMT, CHAT
9response to ATPGO:03319810.4P2RX4, P2RX3
10behavioral response to painGO:04826610.4TACR1, P2RX3
11sensory perception of painGO:01923310.4BDKRB1, CNR2, P2RX4, PENK
12neuromuscular synaptic transmissionGO:00727410.4P2RX3, CHAT
13elevation of cytosolic calcium ion concentrationGO:00720410.3TACR1, NPFF, BDKRB1
14neuropeptide signaling pathwayGO:00721810.2PDYN, NPFF, GAL, PNOC, PENK
15positive regulation of vasoconstrictionGO:04590710.2TACR1, DBH
16inflammatory responseGO:00695410.2BDKRB1, GAL, CNR2, TACR1
17positive regulation of blood pressureGO:04577710.2NPFF, TACR1
18response to lipopolysaccharideGO:03249610.2CNR2, BDKRB1, COMT
19associative learningGO:00830610.1TACR1, BTG2
20positive regulation of calcium-mediated signalingGO:05085010.0P2RX3, P2RX4
21synaptic transmissionGO:0072689.7SLC18A3, COMT, KCNS1, CACNA1B, PDYN, NPFF

Molecular functions related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular ATP-gated cation channel activityGO:00493110.3P2RX3, P2RX4
2opioid peptide activityGO:00151510.0PDYN, PNOC, PENK
3neuropeptide hormone activityGO:00518410.0PENK, PNOC, GAL, NPFF
4purinergic nucleotide receptor activityGO:00161410.0P2RX3, P2RX4

Products for genes affiliated with Chronic Pain

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Pain

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet