MCID: CHR345
MIFTS: 53

Chronic Pain malady

Summaries for Chronic Pain

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
See all sources

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NINDS:44 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).

MalaCards: Chronic Pain, also known as pain - chronic, is related to pain disorder and fibromyalgia. An important gene associated with Chronic Pain is CACNA1B (calcium channel, voltage-dependent, N type, alpha 1B subunit), and among its related pathways are Regulation of thyroid hormone activity and Tyrosine metabolism p.1 (dopamine) . The compounds estrogen and heroin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are cardiovascular system and integument.

MedlinePlus:34 Pain is a feeling set off in the nervous system. acute pain lets you know that you may be injured or have a problem you need to take care of. chronic pain is different. the pain signals go on for weeks, months, or even years. the original cause may have been an injury or infection. there may be an ongoing cause of pain, such as arthritis or cancer. but in some cases there is no clear cause. problems that cause chronic pain include headache low back strain cancer arthritis pain from nerve damage chronic pain usually cannot be cured. but treatments can help. they include medicines, acupuncture, electrical stimulation and surgery. other treatments include psychotherapy, relaxation and meditation therapy, biofeedback, and behavior modification. nih: national institute of neurological disorders and stroke

Wikipedia:64 Chronic pain is defined as pain that has lasted longer than three to six months, though some theorists... more...

Aliases & Classifications for Chronic Pain

Sources:
44NINDS, 34MedlinePlus, 61UMLS
See all sources

Aliases & Descriptions:

chronic pain 44 34 61
pain - chronic 44


Related Diseases for Chronic Pain

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the pain disorder family:

chronic pain

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1pain disorder30.9PNOC, GAL
2fibromyalgia30.3PNOC, TACR1, COMT
3obsessive-compulsive disorder29.8COMT, PDYN, TTF2
4n syndrome10.3
5whiplash10.3
6insomnia10.3
7opioid abuse10.2
8osteoarthritis10.2
9spinal cord injury10.2
10reflex sympathetic dystrophy10.2
11alexithymia10.2
12trigeminal neuralgia10.2
13myofascial pain syndrome10.1
14somatization disorder10.1
15alcohol dependence10.1
16somatoform disorder10.1
17ehlers–danlos syndrome10.1
18sickle cell disease10.1
19back pain10.1
20lumbar disc herniation10.1
21tendinitis10.0
22tendinosis10.0
23major depressive disorder10.0
24chronic interstitial cystitis10.0
25causalgia10.0
26multiple personality disorder10.0
27post-traumatic stress disorder10.0
28chronic fatigue syndrome10.0
29calcific tendinitis10.0
30sleep disorder10.0
31spinal cord disease10.0
32substance dependence10.0
33ehlers-danlos syndrome, hypermobility type10.0
34occipital neuralgia10.0
35pulmonary disease, chronic obstructive10.0
36serotonin syndrome10.0
37chronic pain requiring intraspinal analgesia10.0
38hypertension10.0DBH
39bulimia nervosa10.0COMT
40pancreatitis10.0TACR1
41neuroblastoma10.0DBH, CHAT
42amyotrophic lateral sclerosis10.0SLC18A3, CHAT
43opiate dependence10.0NPFF
44anorexia nervosa10.0GAL, COMT
45multiple sclerosis10.0CNR2, COMT
46myocardial infarction10.0ADRBK1, COMT
47drug dependence10.0PNOC, PDYN
48panic disorder10.0TTF2, COMT
49withdrawal disorder10.0NPFF, PDYN
50hyperprolactinemia10.0DBH, GAL

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to chronic pain

Clinical Features for Chronic Pain

Drugs & Therapeutics for Chronic Pain

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Chronic Pain

Drug clinical trials:

Search ClinicalTrials for Chronic Pain

Search NIH Clinical Center for Chronic Pain

Highlights from CenterWatch's Drugs in Clinical Trials Database for Chronic Pain:

idCompanyCompoundMechanismPhase
1Nektar TherapeuticsNKTR-181A next-generation mu-opioid analgesicII

Genetic Tests for Chronic Pain

Anatomical Context for Chronic Pain

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Chronic Pain:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Whole blood, Cortex, Heart, Smooth muscle, Skeletal muscle, Thyroid, Adrenal gland, Breast, Prostate, Testis, Myeloid, Monocytes, T cells, B cells, Endothelial, Prefrontal cortex, Cingulate cortex, Hypothalamus, Dorsal root ganglion, Trigeminal ganglion, Appendix, Adrenal cortex, Pituitary

Animal Models for Chronic Pain or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Chronic Pain

Sources:
51PubMed
See all sources

Articles related to Chronic Pain:

(show top 50)    (show all 1441)
idTitleAuthorsYear
1
Psychometric properties of the Tampa Scale of Kinesiophobia (TSK-11) among older people with chronic pain. (24410415)
2014
2
Epigenetics of chronic pain after thoracic surgery. (24300461)
2014
3
Immunoglobulin G for the Treatment of Chronic Pain: Report of an Expert Workshop. (24422915)
2014
4
Osteopathic manual treatment and ultrasound therapy for chronic low back pain: an illustration of osteopathic semantic confusion. (24005084)
2013
5
The Role of Sacrolumbar Fat Grafting in the Treatment of Spinal Fusion Instrumentation-Related Chronic Low Back Pain: A Preliminary Report. (24299726)
2013
6
Management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): the studies, the evidence, and the impact. (23568442)
2013
7
A learning and teaching resource on patient self-management of chronic pain. (23518902)
2013
8
The Association of Chronic Back Pain and Stress Urinary Incontinence: A Cross-Sectional Study. (23794961)
2013
9
Chronic Pain Perspectives: Diagnosing fibromyalgia and myofascial pain syndrome: A guide. (24340342)
2013
10
The diagnostic performance of radiography for detection of osteoarthritis-associated features compared with MRI in hip joints with chronic pain. (23842574)
2013
11
Navy medicine's solution to chronic pain. (23756064)
2013
12
Predicting return to work following treatment of chronic pain disorder. (23503298)
2013
13
A mixed-method study exploring suffering and alleviation in participants attending a chronic pain management programme. (23829471)
2013
14
Chronic appendicitis: an often forgotten cause of recurrent abdominal pain. (23177545)
2013
15
Traumatization and chronic pain: a further model of interaction. (24231792)
2013
16
Patterns of care and side effects for patients prescribed methadone for treatment of chronic pain. (24353045)
2013
17
Cost-effectiveness of spinal cord stimulation therapy in management of chronic pain. (23710759)
2013
18
Understanding the role of mitochondria in the pathogenesis of chronic pain. (24151337)
2013
19
Associations Between Chronic Pain Status, Attempts to Quit Smoking, and Use of Pharmacotherapy for Smoking Cessation. (23586459)
2013
20
Osteopathic manual treatment in patients with diabetes mellitus and comorbid chronic low back pain: subgroup results from the OSTEOPATHIC Trial. (23739758)
2013
21
The use of complementary and alternative medicine in chronic pain patients in Singapore: a single-centre study. (23604502)
2013
22
Pain in chronic pancreatitis: managing beyond the pancreatic duct. (24151350)
2013
23
False sense of safety by daily QTc interval monitoring during methadone IVPCA titration in a patient with chronic pain. (23723717)
2013
24
Tramadol plus metamizole combined or not with anti-inflammatory drugs is clinically effective for moderate to severe chronic pain treatment in cancer patients. (23433180)
2013
25
painDETECT questionnaire and lumbar epidural steroid injection for chronic radiculopathy. (23128915)
2013
26
Chronic perinatal pain as a risk factor for postpartum depression symptoms in Canadian women. (24183178)
2013
27
The effect of the neurac sling exercise on postural balance adjustment and muscular response patterns in chronic low back pain patients. (24259906)
2013
28
Brain white matter structural properties predict transition to chronic pain. (24040975)
2013
29
Health related quality of life and pain characteristics among Iranian patients suffering non-malignant chronic pain. (23482882)
2012
30
Prostate extract with aluminum hydroxide injection as a novel animal model for chronic prostatitis/chronic pelvic pain syndrome. (23017785)
2012
31
Acupuncture for chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a systematic review. (21436307)
2012
32
Can arthroscopically assisted treatment of chronic patellar tendinopathy reduce pain and restore function? (21461867)
2012
33
Effects of a 6-month course of tamsulosin for chronic prostatitis/chronic pelvic pain syndrome: a multicenter, randomized trial. (20336302)
2011
34
Chronic prostatitis/chronic pelvic pain: Is there a psychosocial component? (22031614)
2011
35
Chronic iliac vein occlusion and painful nonhealing ulcer induced by high venous pressures from an arteriovenous malformation. (22606547)
2011
36
Microglial GRK2: a novel regulator of transition from acute to chronic pain. (21473908)
2011
37
Early life events: infants with pyloric stenosis have a higher risk of developing chronic abdominal pain in childhood. (21513946)
2011
38
National prevalence of urogenital pain and prostatitis-like symptoms in Australian men using the National Institutes of Health Chronic Prostatitis Symptoms Index. (19549116)
2010
39
Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study. (20167428)
2010
40
Can exposure and acceptance strategies improve functioning and life satisfaction in people with chronic pain and whiplash-associated disorders (WAD)? A randomized controlled trial. (18608312)
2008
41
Etiologic theories of chronic prostatitis/chronic pelvic pain syndrome. (18519015)
2007
42
Chronic pain disorder manifesting as dental pain: case report. (16512099)
2006
43
Brain-derived neurotrophic factor (BDNF) is upregulated and associated with pain in chronic pancreatitis. (11508661)
2001
44
Effective management of ice pick pains, SUNCT, and episodic and chronic paroxysmal hemicrania. (11309219)
2001
45
An outcome study of chronic patellofemoral pain syndrome. Seven-year follow-up of patients in a randomized, controlled trial. (10199273)
1999
46
Superficial siderosis of the CNS as a rare differential diagnosis of chronic low back pain. (10552254)
1999
47
The management of severe chronic pain with a focus on new treatment modalities. (15010710)
1998
48
Psychological differences between reflex sympathetic dystrophy and non-RSD chronic pain patients. (8895237)
1996
49
Substance dependence and chronic pain: profile of 50 patients treated in an alcohol and drug dependence unit. (3763230)
1986
50
Behavior modification of abnormal gait and chronic pain secondary to somatization disorder. (3970659)
1985

Genetic Variations for Chronic Pain

Expression for genes affiliated with Chronic Pain

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Pain

Search GEO for disease gene expression data for Chronic Pain.

Pathways for genes affiliated with Chronic Pain

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 52QIAGEN, 30KEGG
See all sources

Pathways related to Chronic Pain according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3DBH, CHAT
2
Tyrosine metabolism p.1 (dopamine)
Hide members
10.2DBH, COMT
310.2P2RX3, P2RX4, CACNA1B
410.2CACNA1B, CHAT, SLC18A3
510.1TACR1, BTG2, PDYN
6
Hide members
10.0COMT, KCNS1, CACNA1B, CHAT, SLC18A3
7
Hide members
9.9TACR1, GAL, NPFF, BDKRB1
8
Hide members
9.9CACNA1B, GRM2, P2RX4, P2RX3, PENK
9
Hide members
9.9BDKRB1, NPFF, TACR1, ADRBK1
109.9BDKRB1, CACNA1B, TACR1, P2RX4, P2RX3
119.8PDYN, GAL, CHAT, PNOC, SLC18A3, PENK
12
Hide members
9.8COMT, CACNA1B, CHAT, GRM2, SLC18A3, ADRBK1
13
Hide members
9.2BDKRB1, PDYN, NPFF, GAL, GRM2, CNR2
14
Hide members
9.1PENK, BDKRB1, PDYN, NPFF, GAL, GRM2

Compounds for genes affiliated with Chronic Pain

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Chronic Pain according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5PDYN, CHAT, PNOC
2heroin45 50 1112.4COMT, PDYN, CHAT, PENK
3dpdpe29 45 6012.4PNOC, TACR1, PDYN
4npff4510.4PNOC, NPFF, PDYN
5(+-)vesamicol4510.4SLC18A3, CHAT
6homovanillic acid45 2411.3DBH, CHAT, COMT
7etorphine45 29 1112.3PDYN, PNOC, ADRBK1
86-hydroxydopamine4510.3COMT, PDYN, CHAT, DBH, PENK
9naloxone45 50 29 1113.3PDYN, GAL, PNOC, PENK
10clonidine45 29 1112.3CACNA1B, GAL, DBH, TACR1
11atropine45 29 1112.3CACNA1B, PDYN, GAL, TACR1, PNOC
12damgo45 60 2912.3PDYN, TACR1, PNOC, PENK, ADRBK1
13nicotine45 50 29 1113.2COMT, CACNA1B, PDYN, CHAT, DBH, TTF2
14levodopa45 1111.2COMT, PDYN, GAL, DBH
15kainate45 2911.2CACNA1B, PDYN, CHAT, GRM2, TACR1, PENK
16catecholamine4510.2COMT, PDYN, GAL, CHAT, DBH, ADRBK1
17forskolin45 50 1112.2GAL, CHAT, GRM2, DBH, PNOC, PENK
18capsaicin45 2911.2CACNA1B, PDYN, GAL, TACR1, P2RX3, PNOC
19amine4510.2COMT, CHAT, DBH, SLC18A3
20l-amino acid4510.1COMT, CHAT, DBH
21hydrogen45 2411.1COMT, GAL, DBH, CNR2, TTF2, SLC18A3
22choline45 11 2412.1COMT, GAL, CHAT, DBH, TACR1, SLC18A3
23epinephrine45 11 2412.1COMT, CACNA1B, PDYN, GAL, DBH, ADRBK1
24cocaine45 1111.1COMT, PDYN, GAL, CHAT, DBH, PNOC
25lead4510.0ADRBK1, TTF2, DBH, NPFF
26gtp45 2911.0CACNA1B, PDYN, GAL, CNR2, TACR1, TTF2
27ethanol45 50 11 2413.0COMT, PDYN, CHAT, DBH, TACR1, P2RX3
285-hydroxytryptamine4510.0COMT, GAL, CHAT, DBH, TACR1, PNOC
29pge24510.0CACNA1B, PDYN, GAL, DBH, TACR1, PNOC
30adenylate4510.0PDYN, GAL, DBH, CNR2, TACR1, PNOC
31opiate459.9PDYN, NPFF, GAL, DBH, TACR1, PNOC
32nmda45 2910.9COMT, CACNA1B, PDYN, CHAT, GRM2, TACR1
33gaba459.9CACNA1B, PDYN, GAL, CHAT, GRM2, DBH
34norepinephrine45 11 2411.8COMT, CACNA1B, PDYN, GAL, CHAT, DBH
35atp45 2910.8CACNA1B, PDYN, GAL, CHAT, P2RX4, P2RX3
36alanine459.8CACNA1B, GAL, CHAT, DBH, TACR1, TTF2
37sodium45 2410.8CACNA1B, GAL, CHAT, DBH, TACR1, TTF2
38glucose459.8PDYN, GAL, CHAT, DBH, CNR2, TACR1
39morphine45 50 29 1112.7PENK, PNOC, TACR1, DBH, GAL, NPFF
40cysteine459.7PENK, SLC18A3, TTF2, DBH, PDYN, CACNA1B
41acetylcholine45 50 29 11 2413.7CACNA1B, PDYN, GAL, CHAT, DBH, TACR1
42lipid459.7PDYN, GAL, CHAT, DBH, CNR2, TACR1
43progesterone45 60 29 11 2413.7PENK, PNOC, TTF2, TACR1, CHAT, PDYN
44cyclic amp45 2410.6CACNA1B, NPFF, GAL, CHAT, GRM2, DBH
45tyrosine459.5BDKRB1, PDYN, GAL, CHAT, GRM2, DBH
46histamine45 29 2411.5GAL, DBH, TACR1, PNOC, ADRBK1
47dopamine45 29 11 2412.5ADRBK1, COMT, CACNA1B, PENK, SLC18A3, PNOC
48nitric oxide45 11 2411.5DBH, CHAT, GAL, PDYN, BDKRB1, CNR2
49glutamate459.4CHAT, GAL, PDYN, CACNA1B, COMT, GRM2
50calcium45 50 11 2412.0GRM2, CHAT, GAL, NPFF, PDYN, CACNA1B

GO Terms for genes affiliated with Chronic Pain

Sources:
16Gene Ontology
See all sources

Cellular components related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.8TACR1, CNR2, GRM2, NPFF, CACNA1B
2integral to plasma membraneGO:0058879.3BDKRB1, GRM2, CNR2, TACR1, P2RX4, P2RX3
3plasma membraneGO:0058869.2KCNS1, BDKRB1, CACNA1B, PDYN, GRM2, CNR2

Biological processes related to Chronic Pain according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.6COMT, DBH
2purinergic nucleotide receptor signaling pathwayGO:03559010.5P2RX3, P2RX4
3positive regulation of calcium ion transport into cytosolGO:01052410.5P2RX3, P2RX4
4response to painGO:04826510.5DBH, CACNA1B, COMT
5neurotransmitter secretionGO:00726910.5SLC18A3, CHAT, CACNA1B
6tachykinin receptor signaling pathwayGO:00721710.5TACR1, ADRBK1
7positive regulation of leukocyte migrationGO:00268710.4TACR1, BDKRB1
8neurotransmitter biosynthetic processGO:04213610.4COMT, CHAT
9response to ATPGO:03319810.4P2RX4, P2RX3
10behavioral response to painGO:04826610.4TACR1, P2RX3
11sensory perception of painGO:01923310.4BDKRB1, CNR2, P2RX4, PENK
12neuromuscular synaptic transmissionGO:00727410.4P2RX3, CHAT
13elevation of cytosolic calcium ion concentrationGO:00720410.3TACR1, NPFF, BDKRB1
14neuropeptide signaling pathwayGO:00721810.2PDYN, NPFF, GAL, PNOC, PENK
15positive regulation of vasoconstrictionGO:04590710.2TACR1, DBH
16inflammatory responseGO:00695410.2BDKRB1, GAL, CNR2, TACR1
17positive regulation of blood pressureGO:04577710.2NPFF, TACR1
18response to lipopolysaccharideGO:03249610.2CNR2, BDKRB1, COMT
19associative learningGO:00830610.1TACR1, BTG2
20positive regulation of calcium-mediated signalingGO:05085010.0P2RX3, P2RX4
21synaptic transmissionGO:0072689.7SLC18A3, COMT, KCNS1, CACNA1B, PDYN, NPFF

Molecular functions related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular ATP-gated cation channel activityGO:00493110.3P2RX3, P2RX4
2opioid peptide activityGO:00151510.0PDYN, PNOC, PENK
3neuropeptide hormone activityGO:00518410.0PENK, PNOC, GAL, NPFF
4purinergic nucleotide receptor activityGO:00161410.0P2RX3, P2RX4

Products for genes affiliated with Chronic Pain

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  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Pain

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet