MCID: CHR345
MIFTS: 46

Chronic Pain malady

Mental diseases category

Summaries for Chronic Pain

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Sources:
35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).

MalaCards: Chronic Pain, also known as pain - chronic, is related to pain disorder and paine syndrome. An important gene associated with Chronic Pain is CACNA1B (calcium channel, voltage-dependent, N type, alpha 1B subunit), and among its related pathways are Calcium channels and CREB Pathway. The compounds quinpirole and clonidine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes, and related mouse phenotypes are homeostasis/metabolism and integument.

MedlinePlus:35 Pain is a feeling set off in the nervous system. acute pain lets you know that you may be injured or have a problem you need to take care of. chronic pain is different. the pain signals go on for weeks, months, or even years. the original cause may have been an injury or infection. there may be an ongoing cause of pain, such as arthritis or cancer. but in some cases there is no clear cause. problems that cause chronic pain include headache low back strain cancer arthritis pain from nerve damage chronic pain usually cannot be cured. but treatments can help. they include medicines, acupuncture, electrical stimulation and surgery. other treatments include psychotherapy, relaxation and meditation therapy, biofeedback, and behavior modification. nih: national institute of neurological disorders and stroke

Wikipedia:66 Chronic pain is defined as pain that has lasted longer than three to six months, though some theorists... more...

Aliases & Classifications for Chronic Pain

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Sources:
45NINDS, 35MedlinePlus, 63UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

chronic pain 45 35 63
pain - chronic 45


Related Diseases for Chronic Pain

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to chronic pain

Symptoms for Chronic Pain

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Drugs & Therapeutics for Chronic Pain

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Chronic Pain

Drug clinical trials:

Search ClinicalTrials for Chronic Pain

Search NIH Clinical Center for Chronic Pain

Highlights from CenterWatch's Drugs in Clinical Trials Database for Chronic Pain:

idCompanyCompoundMechanismPhase
1Nektar TherapeuticsNKTR-181A next-generation mu-opioid analgesicII

Genetic Tests for Chronic Pain

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Anatomical Context for Chronic Pain

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Sources:
34MalaCards
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MalaCards organs/tissues related to Chronic Pain:

34
Spinal cord, Brain, Testes, Cortex, Eye, Breast, Heart, Cingulate cortex, Dorsal root ganglion, Kidney, Skin, Monocytes, Prefrontal cortex

Animal Models for Chronic Pain or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Chronic Pain:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0P2RX4, CACNA1B, PDYN, GAL, PENK
2MP:00107717.3GAL, PDYN, CACNA1B, CNR2, PENK

Publications for Chronic Pain

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Sources:
53PubMed
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Articles related to Chronic Pain:

(show top 50)    (show all 665)
idTitleAuthorsYear
1
IV. Managing chronic pain: a clinical challenge: new SIGN guidelines provide a practical evidence-based approach and identify research gaps. (24318696)
2014
2
Long-term potentiation in the anterior cingulate cortex and chronic pain. (24298148)
2014
3
Ectopic endometrium-derived leptin produces estrogen-dependent chronic pain in a rat model of endometriosis. (24239717)
2014
4
The phenomenological-existential comprehension of chronic pain: going beyond the standing healthcare models. (24410937)
2014
5
Factors Impacting Variability of the Urinary Normeperidine-to-Meperidine Metabolic Ratio in Patients with Chronic Pain. (24133175)
2014
6
Characteristics of sensitization associated with chronic pain conditions. (23629594)
2014
7
Anxiety and depression in patients with amputated limbs suffering from phantom pain: a comparative study with non-phantom chronic pain. (23543814)
2013
8
Opioids, sensory systems and chronic pain. (23500206)
2013
9
Comment on Lekpa eta88al., 'socio-demographic and clinical profile of chronic pain with neuropathic characteristics in sub-Saharan African elderly'. (23658073)
2013
10
BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. (23510079)
2013
11
The Cognitive Fusion Questionnaire: A Preliminary Study of Psychometric Properties and Prediction of Functioning in Chronic Pain. (24300218)
2013
12
FDA tightens indications for using long-acting and extended-release opioids to treat chronic pain. (24129447)
2013
13
Stress-induced allodynia--evidence of increased pain sensitivity in healthy humans and patients with chronic pain after experimentally induced psychosocial stress. (23950894)
2013
14
Chronic pain treatment: the influence of tricyclic antidepressants on serotonin release and uptake in mast cells. (23710115)
2013
15
Prevalence, causes, severity, impact, and management of chronic pain in Australian general practice patients. (23855874)
2013
16
Medical marijuana for chronic pain. (23940889)
2013
17
A trial of a brief group-based form of acceptance and commitment therapy (ACT) for chronic pain in general practice: pilot outcome and process results. (24035351)
2013
18
The chronic pain initiative and community care of North Carolina. (23940897)
2013
19
Long-term opioid therapy for chronic pain: optimizing management, minimizing risk. (23940887)
2013
20
Self-management intervention for chronic pain in older adults: a randomised controlled trial. (23522927)
2013
21
The Effects of Exercise Therapy for the Improvement of Jaw Movement and Psychological Intervention to Reduce Parafunctional Activities on Chronic Pain in the Craniocervical Region. (23656601)
2013
22
The chronic pain patient and functional assessment: use of the 6-Minute Walk Test in a multidisciplinary pain clinic. (23883277)
2013
23
Low recurrence rate and low chronic pain associated with inguinal hernia repair by laparoscopic placement of Parietex ProGripa8c mesh: clinical outcomes of 220 hernias with mean follow-up at 23 months. (23412779)
2013
24
Glia and pain: is chronic pain a gliopathy? (23792284)
2013
25
Fear of pain and movement in a patient with musculoskeletal chronic pain. (24378448)
2013
26
Effects of ozone applied by spinal endoscopy in patients with chronic pain related to failed back surgery syndrome: a pilot study. (24259984)
2013
27
The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways. (23988582)
2013
28
Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat. (23664545)
2013
29
Intravenous infusions in chronic pain management. (23703410)
2013
30
Topical analgesisc in the management of acute and chronic pain. (24141026)
2013
31
Preliminary results of the clinical effectiveness of percutaneous adhesiolysis using a Racz catheter in the management of chronic pain due to cervical central stenosis. (23877451)
2013
32
Examining the evidence about psychological treatments for chronic pain: time for a paradigm shift? (23742793)
2013
33
"I'm not abusing or anything": patient-physician communication about opioid treatment in chronic pain. (23916677)
2013
34
Demystifying analytical approaches for urine drug testing to evaluate medication adherence in chronic pain management. (24147959)
2013
35
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. (22947198)
2012
36
A primary care-based interdisciplinary team approach to the treatment of chronic pain utilizing a pragmatic clinical trials framework. (23440672)
2012
37
Heterogeneity of chronic pain. (23389871)
2012
38
Health related quality of life and pain characteristics among Iranian patients suffering non-malignant chronic pain. (23482882)
2012
39
Are symptoms of late whiplash specific? A comparison of SCL-90-R symptom profiles of patients with late whiplash and patients with chronic pain due to other types of trauma. (21362758)
2011
40
The neural-glial purinergic receptor ensemble in chronic pain states. (19914722)
2010
41
Vitamin D for the treatment of chronic painful conditions in adults. (20091647)
2010
42
This disorder has some nerve: chronic pain in Guillain-Barre syndrome. (20861453)
2010
43
Uncoupling Src from the NMDA receptor treats chronic pain in rodents. (20408267)
2009
44
Tramadol extended-release in the management of chronic pain. (18488071)
2007
45
Sclerosing polidocanol injections to treat chronic painful shoulder impingement syndrome-results of a two-centre collaborative pilot study. (17028867)
2006
46
Pain anxiety among chronic pain patients: specific phobia or manifestation of anxiety sensitivity? (12547382)
2003
47
The demographics of chronic pain management. (12204483)
2002
48
Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note. (2520402)
1989
49
Behavior modification of abnormal gait and chronic pain secondary to somatization disorder. (3970659)
1985
50
The use of temperature biofeedback in the treatment of chronic pain due to causalgia. (476193)
1979

Variations for Chronic Pain

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Expression for genes affiliated with Chronic Pain

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Pain

Search GEO for disease gene expression data for Chronic Pain.

Pathways for genes affiliated with Chronic Pain

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Sources:
51PathCards, 13EMD Millipore, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Chronic Pain

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB
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Compounds related to Chronic Pain according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1quinpirole46 3010.9PDYN, CACNA1B
2clonidine46 52 30 1212.8GAL, CACNA1B
3damgo46 30 6211.7PENK, PDYN
4heroin46 52 1211.7PDYN, PENK
56-hydroxydopamine469.6PDYN, PENK
6anandamide62 46 30 2512.6CACNA1B, CNR2
7amphetamine46 52 1211.6GAL, PDYN
8carbachol46 30 1211.5GAL, CACNA1B
9levodopa46 1210.5PDYN, GAL
10catecholamine469.4GAL, PDYN
11capsaicin46 3010.4CACNA1B, PDYN, GAL
12atropine46 30 1211.4GAL, PDYN, CACNA1B
13kainate46 3010.4PDYN, CACNA1B, PENK
14cocaine46 1210.3PDYN, GAL
15epinephrine46 25 1211.3GAL, PDYN, CACNA1B
16nmda46 3010.3PDYN, CACNA1B, PENK
17norepinephrine46 25 1211.3CACNA1B, PDYN, GAL
18acetylcholine46 52 30 25 1213.3GAL, PDYN, CACNA1B
19potassium46 25 1211.3GAL, PDYN, CACNA1B
20naloxone46 30 52 1212.2GAL, PDYN, PENK
21pge2469.2CACNA1B, PDYN, GAL
22opiate469.2PENK, PDYN, GAL
23nicotine46 30 52 1212.2PDYN, CACNA1B
24methionine469.2GAL, PDYN, PENK
25hydrogen46 2510.0GAL, CACNA1B, CNR2
26forskolin46 52 1210.9PENK, CNR2, GAL
27atp46 309.9P2RX4, CACNA1B, PDYN, GAL
28oligonucleotide468.9GAL, PDYN, PENK
29morphine46 52 30 1211.9GAL, PDYN, CACNA1B, PENK
30gaba468.9PENK, CACNA1B, PDYN, GAL
31dopamine46 30 25 1211.8PENK, CACNA1B, PDYN, GAL
32oxygen46 259.7CNR2, P2RX4, PENK
33thymidine46 259.7PENK, CNR2, PDYN
34cyclic amp46 259.6GAL, CACNA1B, CNR2, PENK
35gtp46 309.5CNR2, CACNA1B, PDYN, GAL
36glucose468.4P2RX4, CNR2, PDYN, GAL
37adenylate468.4PENK, CNR2, PDYN, GAL
38arginine468.4GAL, PDYN, CNR2, PENK
39nitric oxide46 25 1210.4PENK, CNR2, PDYN, GAL
40tyrosine468.2GAL, PDYN, CNR2, PENK
41glutamate468.0PENK, CNR2, CACNA1B, PDYN, GAL
42calcium46 52 25 1210.6PENK, P2RX4, CNR2, CACNA1B, PDYN, GAL

GO Terms for genes affiliated with Chronic Pain

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Sources:
17Gene Ontology
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Cellular components related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.8PDYN, CACNA1B, CNR2, P2RX4, KCNS1

Biological processes related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane depolarizationGO:0518999.7P2RX4, CACNA1B
2locomotory behaviorGO:0076269.6CACNA1B, PENK
3regulation of blood pressureGO:0082179.4CACNA1B, P2RX4
4synaptic transmissionGO:0072688.9PDYN, CACNA1B, KCNS1
5neuropeptide signaling pathwayGO:0072188.9GAL, PDYN, PENK
6sensory perception of painGO:0192338.8CNR2, P2RX4, PENK

Molecular functions related to Chronic Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4GAL, PENK
2opioid peptide activityGO:0015159.0PDYN, PENK

Products for genes affiliated with Chronic Pain

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Pain

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet