MCID: CHR094
MIFTS: 30

Chronic Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Chronic Polyneuropathy

MalaCards integrated aliases for Chronic Polyneuropathy:

Name: Chronic Polyneuropathy 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5221
NCIt 47 C36071
UMLS 69 C1167650

Summaries for Chronic Polyneuropathy

MalaCards based summary : Chronic Polyneuropathy is related to giant axonal neuropathy-1 and cannabis dependence. An important gene associated with Chronic Polyneuropathy is MAG (Myelin Associated Glycoprotein), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Carbamazepine and Oxcarbazepine have been mentioned in the context of this disorder. Affiliated tissues include testes and kidney, and related phenotype is nervous system.

Related Diseases for Chronic Polyneuropathy

Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Chronic Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
id Related Disease Score Top Affiliating Genes
1 giant axonal neuropathy-1 10.8
2 cannabis dependence 10.7 CD40LG MAG
3 submandibular gland disease 10.7 CD40LG MAG
4 scrotum basal cell carcinoma 10.6 CD40LG PHYH
5 motion sickness 10.6 CD40LG PHYH
6 ocular motility disease 10.5 CD40LG NF1
7 myasthenia gravis 10.5 CD40LG FCGR2B
8 alcoholic neuropathy 10.4 CD40LG CD79A
9 calloso-genital dysplasia 10.4 CD40LG CD79A
10 variola major 10.4 CD40LG CD79A
11 mu chain disease 10.4 CD40LG CD79A
12 rabies 10.4 CD40LG CD79A
13 familial retinoblastoma 10.4 CD40LG CD79A
14 anti-basement membrane glomerulonephritis 10.4 CD40LG CD79A
15 microinvasive cervical squamous cell carcinoma 10.4 CD40LG CD79A
16 fetal erythroblastosis 10.4 CD40LG CD79A
17 spinal canal and spinal cord meningioma 10.4 CD40LG CD79A
18 trichostrongyloidiasis 10.4 CD40LG CD79A
19 leukodystrophy 10.4 CD40LG CD79A
20 retinal microaneurysm 10.4 CD40LG CD79A
21 heart septal defect 10.4 CD40LG CD79A
22 cryptorchidism arachnodactyly mental retardation 10.4 CD40LG CD79A
23 acute kidney tubular necrosis 10.4 CD40LG CD79A
24 secretory meningioma 10.4 CD40LG CD79A
25 hodgkin's lymphoma, nodular sclerosis 10.4 CD40LG CD79A
26 imperforate oropharynx-costo vetebral anomalies 10.4 CD40LG CD79A
27 malignant otitis externa 10.4 CD40LG CD79A
28 transient hypogammaglobulinemia 10.4 CD40LG CD79A
29 benign epilepsy with centrotemporal spikes 10.4 CD40LG CD79A
30 tongue cancer 10.4 CD40LG CD79A
31 hydrops of gallbladder 10.4 CD40LG CD79A
32 gamma heavy chain disease 10.4 CD40LG CD79A
33 diabetic angiopathy 10.4 CD40LG CD79A
34 rosacea conjunctivitis 10.4 CD40LG CD79A
35 viral meningitis 10.4 CD40LG CD79A
36 heart fibrosarcoma 10.4 CD40LG CD79A
37 alopecia areata 10.4 CD40LG CD79A
38 kidney carcinoma in situ 10.4 CD40LG CD79A
39 cardiac tuberculosis 10.4 CD40LG CD79A
40 dumping syndrome 10.4 CD40LG CD79A
41 leiomyosarcoma 10.4 CD40LG CD79A
42 periarthritis 10.4 CD40LG CD79A
43 colonic benign neoplasm 10.4 CD40LG CD79A
44 cerebral neuroblastoma 10.4 CD40LG CD79A
45 pancreatic vasoactive intestinal peptide producing tumor 10.4 CD40LG CD79A
46 oculo-cerebral dysplasia 10.4 CD40LG CD79A
47 aniseikonia 10.4 CD40LG CD79A
48 gestational diabetes 10.4 CD40LG CD79A
49 polyneuropathy due to drug 10.4 CD40LG CD79A
50 chronic mucocutaneous candidiasis 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Chronic Polyneuropathy:



Diseases related to Chronic Polyneuropathy

Symptoms & Phenotypes for Chronic Polyneuropathy

MGI Mouse Phenotypes related to Chronic Polyneuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 PHYH CD40LG CD79A FCGR2B MAG NF1

Drugs & Therapeutics for Chronic Polyneuropathy

Drugs for Chronic Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
2
Oxcarbazepine Approved Phase 4 28721-07-5 34312
3
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 1 148553-50-8 5486971
4
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
5 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
6 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
7 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
8 Analgesics, Non-Narcotic Phase 4
9 Anticonvulsants Phase 4,Phase 3,Phase 2,Phase 1
10 Antimanic Agents Phase 4,Phase 3
11 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
12 Cytochrome P-450 CYP3A Inducers Phase 4
13 Diuretics, Potassium Sparing Phase 4,Phase 2
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Psychotropic Drugs Phase 4,Phase 3,Phase 1
16 Sodium Channel Blockers Phase 4,Phase 2
17 Tranquilizing Agents Phase 4,Phase 3,Phase 1
18 gamma-Globulins Phase 4,Phase 3,Phase 2
19 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
20 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
21 Anti-Anxiety Agents Phase 4,Phase 3,Phase 1
22 calcium channel blockers Phase 4,Phase 3,Phase 1
23 Calcium, Dietary Phase 4,Phase 3,Phase 1
24 Neurotransmitter Agents Phase 4,Phase 3
25 Anesthetics Phase 4,Phase 2
26 Anesthetics, Local Phase 4,Phase 2
27 Anti-Arrhythmia Agents Phase 4,Phase 2
28 Anti-Inflammatory Agents Phase 4,Phase 3
29 glucocorticoids Phase 4,Phase 3
30 Hormone Antagonists Phase 4,Phase 3,Phase 2
31 Hormones Phase 4,Phase 3,Phase 2
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
33 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
34 Analgesics, Opioid Phase 4,Phase 3
35 Narcotics Phase 4,Phase 3
36
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
37
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
38
Hydroxocobalamin Approved Phase 3 13422-51-0 11953898 5460373 44475014
39
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
40
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
41
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
42
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
43
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
44
Mycophenolic acid Approved Phase 3 24280-93-1 446541
45
Oxycodone Approved, Illicit, Investigational Phase 3 76-42-6 5284603
46
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
47
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
48
Thiamine Approved, Nutraceutical, Vet_approved Phase 3 59-43-8 1130
49 tannic acid Approved, Nutraceutical Phase 3
50
gamma-Aminobutyric acid Investigational Phase 3 56-12-2 119

Interventional clinical trials:

(show top 50) (show all 60)

id Name Status NCT ID Phase Drugs
1 Oxcarbazepine for the Treatment of Chronic Peripheral Neuropathic Pain Completed NCT01302275 Phase 4 Oxcarbazepine
2 Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
3 IVIg for Demyelination in Diabetes Mellitus Recruiting NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
4 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
5 Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin Withdrawn NCT01116531 Phase 4 Tramadol;Duloxetine;Pregabalin
6 Alemtuzumab in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD) Withdrawn NCT01757574 Phase 4 Alemtuzumab infusion
7 Lidocaine and Triamcinolone vs Saline Trigger Point Injection for Treatment of Chronic Abdominal Wall Pain Withdrawn NCT02748395 Phase 4 Triamcinolone;Lidocaine
8 Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Chronic Inflammatory Demyelinating Polyneuropathy. Completed NCT01824251 Phase 3 NPB-01
9 Study of Efficacy and Safety of Privigen in Subjects With Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT01184846 Phase 3
10 Extension Study of Maintenance Treatment With Subcutaneous Immunoglobulin (IgPro20) for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Completed NCT02027701 Phase 3
11 Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Treatment With Subcutaneous Immunoglobulin (IgPro20) Completed NCT01545076 Phase 3
12 Immune Globulin Intravenous (IGIV) For Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Completed NCT00220740 Phase 3 Immune Globulin IV (Human), 10% Caprylate/Chromatography Purified;Albumin (Human) 25%, United States Pharmacopeia (USP)
13 Randomized Open-label Trial to Compare Efficacy and Tolerance of Corticosteroids and IVIg Completed NCT01349270 Phase 3 Immunoglobulin perfusion;Prednisone
14 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Immune Globulin for Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT00004772 Phase 3 Immune globulin
15 Neuropathic Pain Management Completed NCT01263132 Phase 3 F0434;Gabapentin
16 Phase III Randomized, Double-Blind, Placebo-Controlled Study of 3,4-Diaminopyridine for Demyelinating Polyneuropathy Completed NCT00004939 Phase 3 ,4-diaminopyridine
17 Phase III Multicenter Double Blind Controlled Trial of Human Immune Globulin Therapy in Previously Untreated Patients With Chronic Inflammatory Demyelinating Neuropathy Completed NCT00004286 Phase 3 immune globulin
18 A Study to Evaluate the Efficacy, Safety, and Tolerability of Tapentadol ER Compared With Placebo in Patients With Chronic, Painful Diabetic Peripheral Neuropathy Completed NCT01041859 Phase 3 Tapentadol extended release (ER);Placebo
19 Evaluate The Efficacy and Safety Of Pregabalin In Prevention, Reduction of Oxaliplatin-Induced Painful Neuropathy Completed NCT01450163 Phase 3 Pregabalin, Oxaliplatin;Placebo , Oxaliplatin
20 Evaluate Efficacy and Safety of Fingolimod 0.5 mg Orally Once Daily Versus Placebo in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients. Completed NCT01625182 Phase 3 Fingolimod;Placebo Comparator
21 Study to Evaluate Safety and Efficacy of Three Different Dosages of NewGam in Patients With Chronic Inflammatory Demyelinating Poly (Radiculo) Neuropathy Recruiting NCT02638207 Phase 3 NewGam
22 Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness Recruiting NCT03038919 Phase 2, Phase 3 Testosterone cypionate
23 Phase III Efficacy, Safety, and Tolerability Study of HYQVIA/HyQvia and GAMMAGARD LIQUID/KIOVIG in CIDP Recruiting NCT02549170 Phase 3
24 Interest of Mycophenolate for CIDP Weaning Active, not recruiting NCT02494505 Phase 3 Mycophenolate Mofetil;placebo
25 Panzyga in CIDP Administered at Different Infusion Rates Not yet recruiting NCT03166527 Phase 3 Immune Globulin 10% Intravenous Solution
26 A Long-term Safety Study With Tapentadol ER and Oxycodone CR in Patients With Moderate to Severe Pain Due to Chronic, Painful Diabetic Peripheral Neuropathy (DPN) Terminated NCT01063868 Phase 3 Tapentadol extended release (ER);Oxycodone controlled release (CR)
27 Lipoic Acid to Treat Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT00962429 Phase 2 lipoic acid
28 A Study to Determine if Levetiracetam Will Assist Those Suffering From Chronic Idiopathic Axonal Polyneuropathy. Completed NCT00156689 Phase 2 levetiracetam
29 Intravenous Immunoglobulin (IVIg) for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Completed NCT00001287 Phase 2 intravenous immunoglobulin (IVIg)
30 Painful Diabetic Polyneuropathy Trial With a New Centrally Acting Analgesic Completed NCT00878293 Phase 2 GRT6005;MS Continus®;Placebo
31 Safety and Efficacy of GRT6005 in Pain Due to Diabetic Polyneuropathy Completed NCT01347671 Phase 2 GRT6005;GRT6005;GRT6005;Matching Placebo
32 Subcutaneous Immunoglobulin Treatment of Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Completed NCT01017159 Phase 2 Subcutaneous immunoglobulin
33 Safety and Efficacy of Avonex in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Completed NCT00099489 Phase 2 Interferon Beta-1a
34 SERENDEM : MD1003 in Patients Suffering From Demyelinating Neuropathies, an Open Label Pilot Study Recruiting NCT02967679 Phase 1, Phase 2 MD1003
35 Stem Cell Transplantation for Stiff Person Syndrome (SPS) Recruiting NCT02282514 Phase 1, Phase 2
36 A Trial of Lidocaine Patch for Lower Limb Amputation Pain Recruiting NCT02696720 Phase 2 Lidocaine
37 Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy Active, not recruiting NCT00278629 Phase 2
38 High-dose Cyclophosphamide for Moderate to Severe Refractory Chronic Inflammatory Demyelinating Polyneuropathy Withdrawn NCT01236456 Phase 2 Cyclophosphamide
39 Pilot Study of Acthar® Gel in Chronic Inflammatory Demyelinating Neuropathy Withdrawn NCT02574962 Phase 2 H.P. Acthar® Gel
40 Intravenous Levetiracetam as First-line Anticonvulsive Treatment in Patients With Non-convulsive Status Epilepticus Withdrawn NCT00603135 Phase 2 first-line i/v-levetiracetam
41 Neuropathic Pain Syndrome Patient Study (MK-0000-072) Completed NCT00570310 Phase 1 Comparator: pregabalin;Comparator: Placebo (unspecified)
42 Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Unknown status NCT01379833
43 sCD163 & CD19 as Candidate Biomarkers in CIDP and MMN Unknown status NCT02271724
44 Small-fiber Neuropathy in Chronic Kidney Disease Unknown status NCT01078857
45 MoCa Test for the Early Detection of Mild Cognitive Impairment During Annual Assessment of Young Adults With Diabetes and in a Control Group Without Diabetes Unknown status NCT02545062
46 Effect of Resistance and Aerobic Exercise in CIDP or MMN Completed NCT02121678
47 Immunoglobulin Dosage and Administration Form in CIDP and MMN Completed NCT02111590 Immunoglobulins
48 Lidocaine 5% Patch (Lidoderm) for the Perioperative Prevention of Acute and Chronic Chest Pain Following Robotic Valve Surgery Completed NCT03120351 Lidoderm 5 % Topical Patch;Placebo patch
49 Magnetic Resonance Diagnostics of Diabetic Peripheral Neuropathy Completed NCT01847937
50 Treatment of Painful Diabetic Neuropathy With Photon Stimulation Completed NCT00539175

Search NIH Clinical Center for Chronic Polyneuropathy

Genetic Tests for Chronic Polyneuropathy

Anatomical Context for Chronic Polyneuropathy

MalaCards organs/tissues related to Chronic Polyneuropathy:

39
Testes, Kidney

Publications for Chronic Polyneuropathy

Articles related to Chronic Polyneuropathy:

(show all 23)
id Title Authors Year
1
The epidemiology and risk factors of chronic polyneuropathy. ( 26700499 )
2016
2
A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy. ( 18691815 )
2008
3
Feasibility and cost efficiency of a diagnostic guideline for chronic polyneuropathy: a prospective implementation study. ( 16484653 )
2006
4
Chronic polyneuropathy and Lyme disease. ( 17038034 )
2006
5
Diagnostic investigation of patients with chronic polyneuropathy: evaluation of a clinical guideline. ( 11459893 )
2001
6
Evaluation of patients with symptoms suggestive of chronic polyneuropathy. ( 19078654 )
2001
7
Prospective follow-up study of chronic polyneuropathy of undetermined cause. ( 11494273 )
2001
8
Vocal cord paralysis and respiratory muscle weakness: an unusual presentation of chronic polyneuropathy. ( 9707455 )
1998
9
Detection of Borrelia burgdorferi DNA and complement membrane attack complex deposits in the sural nerve of a patient with chronic polyneuropathy and tertiary Lyme disease. ( 9236787 )
1997
10
Primary SjAPgren's syndrome in chronic polyneuropathy presenting in middle or old age. ( 7931401 )
1994
11
IgG antibody against GM1, GD1b and asialo-GM1 in chronic polyneuropathy following Mycoplasma pneumoniae infection. ( 1563451 )
1992
12
Comparison of electrodiagnostic criteria for primary demyelination in chronic polyneuropathy. ( 1944409 )
1991
13
Treatment of idiopathic chronic polyneuropathy with plasma exchange alone. ( 2352988 )
1990
14
Two cases of Dandy-Walker syndrome and chronic polyneuropathy. ( 2485913 )
1989
15
Chronic polyneuropathy and ulcerative colitis. ( 2724650 )
1989
16
Delayed chronic polyneuropathy following organophosphate poisoning: a case report. ( 2845234 )
1987
17
Humoral abnormalities in three patients with idiopathic chronic polyneuropathy. ( 3895061 )
1985
18
Chronic polyneuropathy of undetermined cause. ( 6330306 )
1984
19
Ultrastructure of the sural nerve in chronic polyneuropathy associated with Adie's syndrome. ( 4446945 )
1974
20
Familial chronic polyneuropathy with crampiform manifestations. ( 4187191 )
1969
21
Hereditary chronic polyneuropathy. Electrophysiological and pathological studies in an affected family. ( 4185983 )
1969
22
Aspects of chronic polyneuropathy associated with myeloma. ( 5707163 )
1968
23
The relation between chronic polyneuropathy and osteosclerotic myeloma. ( 6075207 )
1967

Variations for Chronic Polyneuropathy

Expression for Chronic Polyneuropathy

Search GEO for disease gene expression data for Chronic Polyneuropathy.

Pathways for Chronic Polyneuropathy

Pathways related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Chronic Polyneuropathy

Cellular components related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD40LG CD79A

Biological processes related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neural tube development GO:0021915 9.16 NF1 PHGDH
2 B cell proliferation GO:0042100 8.96 CD40LG CD79A
3 spinal cord development GO:0021510 8.62 NF1 PHGDH

Sources for Chronic Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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