MCID: CHR097
MIFTS: 21

Chronic Purulent Otitis Media malady

Categories: Ear diseases

Aliases & Classifications for Chronic Purulent Otitis Media

Aliases & Descriptions for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 14 69
Chronic Suppurative Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14247
ICD10 33 H66.3
ICD9CM 35 382.3
UMLS 69 C0271454

Summaries for Chronic Purulent Otitis Media

Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to chronic atticoantral disease and otitis media. An important gene associated with Chronic Purulent Otitis Media is HSF4 (Heat Shock Transcription Factor 4). The drugs Dexamethasone and Ciprofloxacin have been mentioned in the context of this disorder.

Related Diseases for Chronic Purulent Otitis Media

Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 chronic atticoantral disease 11.2
2 otitis media 10.4
3 labyrinthitis 9.9
4 cholesteatoma 9.9
5 hypertensive heart disease 9.9 HSF4 TLR2 WIPF1
6 down syndrome 8.8 COCH CTNS HINT1 HSF4 NR2F1 TLR2

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media

Symptoms & Phenotypes for Chronic Purulent Otitis Media

Drugs & Therapeutics for Chronic Purulent Otitis Media

Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
4 Cytochrome P-450 Enzyme Inhibitors Phase 4
5 Anti-Bacterial Agents Phase 4,Phase 1
6 Anti-Infective Agents Phase 4,Phase 1
7 Topoisomerase Inhibitors Phase 4,Phase 1
8 Dexamethasone acetate Phase 4 1177-87-3
9 glucocorticoids Phase 4
10
protease inhibitors Phase 4
11 N-monoacetylcystine Phase 4
12 Gastrointestinal Agents Phase 4
13 HIV Protease Inhibitors Phase 4
14 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
15 Hormone Antagonists Phase 4
16 Dexamethasone 21-phosphate Phase 4
17 Hormones Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
20 Pharmaceutical Solutions Phase 4
21 Expectorants Phase 4
22 Protective Agents Phase 4
23 Antidotes Phase 4
24 Antiemetics Phase 4
25 Anti-Inflammatory Agents Phase 4
26 Respiratory System Agents Phase 4
27 BB 1101 Phase 4
28 Autonomic Agents Phase 4
29 Antineoplastic Agents, Hormonal Phase 4
30 Antiviral Agents Phase 4
31 Antioxidants Phase 4
32 Nucleic Acid Synthesis Inhibitors Phase 1
33 Pazufloxacin Phase 1
34 Fluoroquinolones Phase 1
35 Antitubercular Agents Phase 1
36
Sulfamethoxazole Approved 723-46-6 5329
37
Trimethoprim Approved, Vet_approved 738-70-5 5578
38
leucovorin Approved, Nutraceutical 58-05-9 54575, 6560146 143
39
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
40 Folic Acid Antagonists
41 Trimethoprim, Sulfamethoxazole Drug Combination
42 Vitamin B Complex
43 Antimalarials
44 Renal Agents
45 Antiparasitic Agents
46 Antiprotozoal Agents
47 Folate Nutraceutical
48 Vitamin B9 Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4
2 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
3 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Recruiting NCT02592096 Phase 1
4 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
5 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098
6 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Recruiting NCT02779907
7 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376

Search NIH Clinical Center for Chronic Purulent Otitis Media

Genetic Tests for Chronic Purulent Otitis Media

Anatomical Context for Chronic Purulent Otitis Media

Publications for Chronic Purulent Otitis Media

Articles related to Chronic Purulent Otitis Media:

id Title Authors Year
1
Chronic purulent otitis media: the prevailing pathology form among northern nationalities. ( 1365253 )
1991
2
Study of diffusion of cefuroxime into middle ear effusions of patients with chronic purulent otitis media. ( 7142073 )
1982
3
The treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. ( 18143038 )
1949
4
Modified technic of plastic procedure in radical mastoidectomy; report of results in a case of circumscribed labyrinthitis and periphlebitis of the lateral sinus in the course of chronic purulent otitis media with cholesteatoma. ( 15394995 )
1949
5
A different treatment of chronic purulent otitis media; deep lavage, aeration and application of gold foil membrane bearing ointment of scarlet red. ( 18896820 )
1947
6
Chronic purulent otitis media. ( 20260367 )
1947
7
Chronic purulent otitis media. ( 18919212 )
1947
8
Treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. ( 20993474 )
1946
9
Chronic Purulent Otitis Media: Its Treatment with Iodin Powder (Sulzberger). ( 18742568 )
1933
10
Indications for Operation in Chronic Purulent Otitis Media. ( 18734787 )
1909

Variations for Chronic Purulent Otitis Media

Expression for Chronic Purulent Otitis Media

Search GEO for disease gene expression data for Chronic Purulent Otitis Media.

Pathways for Chronic Purulent Otitis Media

GO Terms for Chronic Purulent Otitis Media

Sources for Chronic Purulent Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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