MCID: CHR097
MIFTS: 26

Chronic Purulent Otitis Media

Categories: Ear diseases

Aliases & Classifications for Chronic Purulent Otitis Media

MalaCards integrated aliases for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 14 69
Chronic Suppurative Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14247
ICD10 32 H66.3
ICD9CM 34 382.3
UMLS 69 C0271454

Summaries for Chronic Purulent Otitis Media

Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to chronic atticoantral disease and otitis media. An important gene associated with Chronic Purulent Otitis Media is TLR9 (Toll Like Receptor 9). The drugs Acetylcysteine and Ciprofloxacin have been mentioned in the context of this disorder. Related phenotype is digestive/alimentary.

Related Diseases for Chronic Purulent Otitis Media

Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 chronic atticoantral disease 11.3
2 otitis media 10.5
3 focal labyrinthitis 10.0
4 labyrinthitis 10.0
5 cholesteatoma 10.0
6 suppurative otitis media 9.9 HSF4 WIPF1
7 hematologic cancer 9.7 RUNX1T1 TLR9

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media

Symptoms & Phenotypes for Chronic Purulent Otitis Media

MGI Mouse Phenotypes related to Chronic Purulent Otitis Media:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 FLNA RUNX1T1 TLR9 WIPF1

Drugs & Therapeutics for Chronic Purulent Otitis Media

Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4 Anti-Bacterial Agents Phase 4,Phase 1
5 Anti-Infective Agents Phase 4,Phase 1
6 Topoisomerase Inhibitors Phase 4,Phase 1
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Antidotes Phase 4
9 Antiemetics Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Antioxidants Phase 4
13 Antiviral Agents Phase 4
14 Autonomic Agents Phase 4
15 BB 1101 Phase 4
16 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
17 Dexamethasone acetate Phase 4 1177-87-3
18 Expectorants Phase 4
19 Gastrointestinal Agents Phase 4
20 glucocorticoids Phase 4
21 HIV Protease Inhibitors Phase 4
22 Hormone Antagonists Phase 4
23 Hormones Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 N-monoacetylcystine Phase 4
26 Peripheral Nervous System Agents Phase 4
27 Pharmaceutical Solutions Phase 4
28
protease inhibitors Phase 4
29 Protective Agents Phase 4
30 Respiratory System Agents Phase 4
31 Pazufloxacin Investigational Phase 1 127045-41-4
32 Antitubercular Agents Phase 1
33 Fluoroquinolones Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 1
35
Sulfamethoxazole Approved 723-46-6 5329
36
Trimethoprim Approved, Vet_approved 738-70-5 5578
37
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
38
leucovorin Approved, Nutraceutical 58-05-9 143 6006
39 Antimalarials
40 Antiparasitic Agents
41 Antiprotozoal Agents
42 Folic Acid Antagonists
43 Renal Agents
44 Trimethoprim, Sulfamethoxazole Drug Combination
45 Vitamin B Complex
46 Folate Nutraceutical
47 Vitamin B9 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
3 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
4 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Sulfamethoxazole-trimethoprim;Placebo
5 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Recruiting NCT02779907
6 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
7 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376

Search NIH Clinical Center for Chronic Purulent Otitis Media

Genetic Tests for Chronic Purulent Otitis Media

Anatomical Context for Chronic Purulent Otitis Media

Publications for Chronic Purulent Otitis Media

Articles related to Chronic Purulent Otitis Media:

# Title Authors Year
1
Chronic purulent otitis media: the prevailing pathology form among northern nationalities. ( 1365253 )
1991
2
Study of diffusion of cefuroxime into middle ear effusions of patients with chronic purulent otitis media. ( 7142073 )
1982
3
Modified technic of plastic procedure in radical mastoidectomy; report of results in a case of circumscribed labyrinthitis and periphlebitis of the lateral sinus in the course of chronic purulent otitis media with cholesteatoma. ( 15394995 )
1949
4
The treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. ( 18143038 )
1949
5
Chronic purulent otitis media. ( 18919212 )
1947
6
Chronic purulent otitis media. ( 20260367 )
1947
7
A different treatment of chronic purulent otitis media; deep lavage, aeration and application of gold foil membrane bearing ointment of scarlet red. ( 18896820 )
1947
8
Treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. ( 20993474 )
1946
9
Chronic Purulent Otitis Media: Its Treatment with Iodin Powder (Sulzberger). ( 18742568 )
1933
10
Indications for Operation in Chronic Purulent Otitis Media. ( 18734787 )
1909

Variations for Chronic Purulent Otitis Media

Expression for Chronic Purulent Otitis Media

Search GEO for disease gene expression data for Chronic Purulent Otitis Media.

Pathways for Chronic Purulent Otitis Media

GO Terms for Chronic Purulent Otitis Media

Cellular components related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament GO:0005884 8.62 FLNA WIPF1

Biological processes related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 8.62 TLR9 TNN

Sources for Chronic Purulent Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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