MCID: CHR098
MIFTS: 48

Chronic Pyelonephritis malady

Nephrological diseases category
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Summaries for Chronic Pyelonephritis

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MalaCards based summary: Chronic Pyelonephritis is related to pyelonephritis and bacteriuria. An important gene associated with Chronic Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are TCR signaling in naive CD4+ T cells and Downstream signaling in naive CD8+ T cells. The compounds 99mtc-dmsa and amikacin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and cortex, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Classifications for Chronic Pyelonephritis

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Chronic Pyelonephritis, Aliases & Descriptions:

Name: Chronic Pyelonephritis 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:1076
ICD9CM27 590.0

Related Diseases for Chronic Pyelonephritis

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Diseases in the Pyelonephritis family:

Acute Pyelonephritis chronic pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis31.9B2M, NAGLU, UMOD, CD79A
2bacteriuria31.1UMOD
3hypertension31.1CD79A, ALB, CALCA
4prostatitis30.9CD79A
5vesicoureteral reflux30.8NAGLU, UMOD
6nephritis30.7CD79A, ALB, B2M
7cystitis30.6NAGLU, UMOD
8nephrotic syndrome30.4CD79A, ALB, NAGLU, B2M
9glomerulonephritis30.3CD79A, ALB, UMOD, NAGLU, B2M
10uremia30.3ALB, B2M
11proteinuria30.2B2M, NAGLU, UMOD, ALB, CD79A
12amyloidosis30.1B2M, ALB, CD79A
13hepatitis29.9ALB, HLA-A
14myeloma29.7B2M, NAGLU, UMOD, ALB, CD79A
15tuberculosis29.4HLA-A, CP, ALB, CD79A
16chronic kidney failure29.2HLA-A, B2M, NAGLU, UMOD, ALB, CD79A
17diabetes mellitus28.5HLA-A, B2M, CP, NAGLU, UMOD, CALCA
18osteitis fibrosa10.5B2M
19protein-losing enteropathy10.4ALB
20hyperthyroxinemia10.4ALB
21hepatorenal syndrome10.4ALB
22acute poststreptococcal glomerulonephritis10.4CD79A
23gastroenteritis10.4CD79A
24hemosiderosis10.4CP
25urinary system disease10.4B2M, NAGLU
26acute kidney tubular necrosis10.4B2M, NAGLU
27nephrolithiasis10.4NAGLU, UMOD
28nephrocalcinosis10.3NAGLU, UMOD
29malignant hypertension10.3
30pseudohypoparathyroidism10.3NAGLU, CALCA
31paget's disease of bone10.3B2M, CALCA
32hypoparathyroidism10.3NAGLU, CALCA
33hypophosphatemia10.3B2M, CALCA
34hydronephrosis10.3
35macroglobulinemia10.3B2M, CD79A
36urinary tract obstruction10.2B2M, NAGLU, UMOD
37plasmacytoma10.2B2M, CD79A
38acquired immunodeficiency syndrome10.2ALB, B2M
39hemochromatosis10.2CP, B2M
40peripheral vascular disease10.2CD79A, ALB
41thyroiditis10.2CALCA, CD79A
42membranous glomerulonephritis10.2ALB, CD79A
43metabolic acidosis10.2B2M, ALB
44urethritis10.2
45nephrosclerosis10.2
46interstitial nephritis10.2
47peritonitis10.2B2M, ALB
48hyperparathyroidism10.2ALB, CALCA
49acute liver failure10.2CP, ALB
50rhinitis10.2CD79A, ALB

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to chronic pyelonephritis

Symptoms for Chronic Pyelonephritis

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Drugs & Therapeutics for Chronic Pyelonephritis

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Drug clinical trials:

Search ClinicalTrials for Chronic Pyelonephritis

Search NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

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Anatomical Context for Chronic Pyelonephritis

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MalaCards organs/tissues related to Chronic Pyelonephritis:

32
Kidney, Testes, Cortex, Prostate, Spinal cord, Liver, Ovary

Animal Models for Chronic Pyelonephritis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Pyelonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5CD79A, UMOD, NAGLU, CP, B2M
2MP:00053708.1B2M, CP, NAGLU, ALB
3MP:00053678.1CD79A, ALB, CALCA, UMOD, NAGLU
4MP:00053767.4B2M, CP, UMOD, CALCA, ALB, CD79A

Publications for Chronic Pyelonephritis

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Articles related to Chronic Pyelonephritis:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
Chronic pyelonephritis presenting as multiple tumor-like renal lesions. (17575382)
2007
2
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
3
Computed tomography evaluation of renal parenchymal volume in patients with chronic pyelonephritis and its relationship to glomerular filtration rate. (7735742)
1995
4
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
5
The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. (7532880)
1994
6
Atubular glomeruli in patients with chronic pyelonephritis. (2332970)
1990
7
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. (2680194)
1989
8
P-fimbriae receptors in patients with chronic pyelonephritis. (2896254)
1988
9
Auto-antibody to kidney tubular cells during retrograde chronic pyelonephritis in rats. (3885065)
1985
10
Role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis. (3912177)
1985
11
Immunopathology of the glomerular changes in chronic pyelonephritis. (386707)
1979
12
Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. (633491)
1978
13
Long-term study of humoral immune response in patients with chronic pyelonephritis. (788977)
1976
14
Diagnostic value of ceruloplasmin, haptoglobin and sialic acid in chronic pyelonephritis. (965209)
1976
15
Hypertension in children with chronic pyelonephritis. (1059804)
1975
16
The occurrence of mycoplasmas in the urinary tract of patients with chronic pyelonephritis. (1130197)
1975
17
Letter: Urinary reflux and chronic pyelonephritis. (46073)
1975
18
The incidence of chronic pyelonephritis in schistosomal hepatic fibrosis utilising the prednisolone provocation test. (4726339)
1973
19
Improved treatment of chronic pyelonephritis with nitrofurantoin in combination with deglycyrrhizinated liquorice. (4556768)
1972
20
What is chronic pyelonephritis? (5551266)
1971
21
Chronic pyelonephritis and renal medullary necrosis. (5155285)
1971
22
Medical management of chronic pyelonephritis: acute and chronic. (5428975)
1970
23
Effect of water diuresis on chronic pyelonephritis. (5659542)
1968
24
Chronic pyelonephritis: relative incidence in transplant recipients. (5330923)
1966
25
Asymmetry of renal function with special references to chronic pyelonephritis. (5220569)
1966
26
UROLOGICAL SURVEY OF CHRONIC PYELONEPHRITIS AND RECURRENT URINARY INFECTION WITHOUT OBSTRUCTION. (14269350)
1965
27
A NEW ANTIMICROBIAL AGENT, NEGGRAM, USED IN CHRONIC PYELONEPHRITIS. (14340960)
1965
28
PATHOGENESIS OF CHRONIC PYELONEPHRITIS. II. EFFECT OF REPETITIVE INFECTION. (14223578)
1964
29
ROLE OF CHRONIC PYELONEPHRITIS IN THE PRODUCTION OF EXPERIMENTAL HYDRONEPHROSIS. (14226454)
1964
30
POTASSIUM DEPLETION AND CHRONIC PYELONEPHRITIS. (14124095)
1964
31
CHRONIC PYELONEPHRITIS AND THE ANTIBIOTICS. (14062883)
1963
32
Long-term treatment of chronic pyelonephritis in children. (13955227)
1963
33
Presentation and diagnosis of chronic pyelonephritis. (13928854)
1963
34
Problems of chronic pyelonephritis. (13974947)
1963
35
Multiple-antibiotic-resistant enteric bacilli in chronic pyelonephritis. A one-year study in the Philippine General Hospital. (14465338)
1962
36
The finding of chronic pyelonephritis in males and females at autopsy. (13756618)
1960
37
Hematogenous pyelonephritis in rats. IV. Relationship of bacterial species to the pathogenesis and sequelae of chronic pyelonephritis. (13664797)
1959
38
Chronic pyelonephritis lenta and the "malignant phase of hypertension". (14441666)
1959
39
Chronic pyelonephritis. (13668710)
1959
40
Unilateral renal function in chronic pyelonephritis and renal papillary necrosis; a study on the function of the separate kidneys with the aid of selective renal clearance and renal vein catheterization. (13558903)
1958
41
The pathogenesis of chronic pyelonephritis. (13610072)
1958
42
Hyperchloremic acidosis in chronic pyelonephritis. (13552915)
1958
43
Chronic pyelonephritis with xanthogranulomatous change; report of 3 cases. (13248828)
1955
44
Chronic pyelonephritis. (13131022)
1954
45
Polymyxin B in chronic pyelonephritis: observations on the safety of the drug and on its influence on the renal infection. (13030476)
1953
46
WEEKLY clinicopathological exercises; ectopic left kidney (in pelvis) with chronic pyelonephritis; congenital absence of right kidney, ovary & salpinx. (14890819)
1952
47
Clinico-pathological conference: hypoplasia of the kidneys secondary to chronic pyelonephritis; acute bronchitis; myocardial hypertrophy; fatty metamorphosis of the liver; rickets. (14870327)
1951
48
Chronic pyelonephritis simulating Addison's disease. (15413207)
1950
49
Chronic pyelonephritis and hypertension. (14795114)
1950
50
Pregnancy following lumbodorsal splanchnicectomy for essential and malignant hypertension and hypertension associated with chronic pyelonephritis. (20241256)
1947

Variations for Chronic Pyelonephritis

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Expression for genes affiliated with Chronic Pyelonephritis

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Expression patterns in normal tissues for genes affiliated with Chronic Pyelonephritis

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Pathways for genes affiliated with Chronic Pyelonephritis

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Compounds for genes affiliated with Chronic Pyelonephritis

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Compounds related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
199mtc-dmsa4410.0NAGLU, B2M
2amikacin4410.0NAGLU, B2M
3tobramycin449.9NAGLU, B2M
4fosfomycin449.9NAGLU, B2M
5dmsa449.8B2M, NAGLU, CALCA
6aluminium44 1110.7B2M, NAGLU
7pmma449.6CD79A, CALCA, B2M
8polyether sulfone449.5ALB, B2M
9neopterin449.5B2M, NAGLU, CD79A
10mesna449.5B2M, NAGLU
1151-cr-edta449.5ALB, B2M
12iopentol449.4ALB, NAGLU, B2M
13p-aminohippuric acid449.4ALB, NAGLU, B2M
14inulin449.4B2M, NAGLU, ALB
15iohexol449.4B2M, NAGLU, ALB
16fluoride449.3B2M, NAGLU, CALCA, CD79A
17sevoflurane50 44 1111.3B2M, NAGLU, ALB
18galactose449.3CD79A, UMOD, B2M
19isoflurane50 44 1111.3ALB, CALCA, NAGLU
20vitamin-e449.3NAGLU, CP, B2M
21gamma globulin449.2B2M, ALB, CD79A
22sialic acid449.2CD79A, UMOD, NAGLU, CP
23furosemide44 61 28 50 24 1114.2NAGLU, CALCA, ALB
2425-hydroxyvitamin d449.2ALB, CALCA, B2M
25cellulose acetate449.2CD79A, ALB, B2M
26urea44 24 1111.0B2M, NAGLU, UMOD, ALB
27phosphorus449.0B2M, NAGLU, CALCA, ALB
28carbamazepine44 50 1111.0CD79A, NAGLU, CP, HLA-A
29phenytoin44 50 28 1111.9CP, ALB, CD79A
30hyaluronic acid44 249.9B2M, NAGLU, ALB, CD79A
31captopril44 61 50 28 1112.8CD79A, ALB, CALCA, B2M
32mannitol44 119.8B2M, CP, NAGLU, ALB
33vitamin a44 24 1110.8B2M, CP, NAGLU, ALB
34vitamin b12448.7B2M, CP, ALB, CD79A
35cyclosporin a44 28 6110.7CD79A, CALCA, NAGLU, B2M, HLA-A
36folate448.7B2M, CP, ALB, CD79A
37tacrolimus44 50 1110.6HLA-A, NAGLU, ALB, CD79A
38uric acid44 249.5B2M, CP, NAGLU, UMOD, ALB
39citrate448.5CP, NAGLU, UMOD, ALB, CD79A
40heparin44 28 24 1111.4CP, NAGLU, UMOD, ALB, CD79A
41thyroxine44 249.3B2M, CP, CALCA, ALB, CD79A
42indomethacin44 28 61 1111.3B2M, CP, CALCA, ALB, CD79A
43cholesterol44 28 24 1111.2B2M, CP, NAGLU, LPXN, ALB
44testosterone44 61 24 1111.2B2M, CP, CALCA, ALB, CD79A
45glucose448.2B2M, NAGLU, LPXN, UMOD, ALB
46vitamin d448.0B2M, CP, NAGLU, CALCA, ALB, CD79A
47cysteine448.0B2M, CP, NAGLU, UMOD, ALB, CD79A
48lactate448.0B2M, CP, NAGLU, CALCA, ALB, CD79A
49alanine447.8HLA-A, B2M, CP, NAGLU, ALB, CD79A
50creatinine447.7CD79A, ALB, CALCA, UMOD, NAGLU, CP

GO Terms for genes affiliated with Chronic Pyelonephritis

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Cellular components related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:0306709.5B2M, HLA-A
2MHC class I protein complexGO:0426129.4B2M, HLA-A
3ER to Golgi transport vesicle membraneGO:0125079.2B2M, HLA-A
4extracellular spaceGO:0056158.0B2M, CP, UMOD, CALCA, ALB
5extracellular vesicular exosomeGO:0700627.5ALB, UMOD, NAGLU, CP, B2M, HLA-A

Biological processes related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.6B2M, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.5B2M, HLA-A
3regulation of defense response to virus by virusGO:0506909.5B2M, HLA-A
4interferon-gamma-mediated signaling pathwayGO:0603339.5B2M, HLA-A
5response to organic substanceGO:0100339.2UMOD, ALB
6retina homeostasisGO:0018959.0ALB, B2M

Molecular functions related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.1ALB, CP
2chaperone bindingGO:0510878.8ALB, CP

Products for genes affiliated with Chronic Pyelonephritis

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Sources for Chronic Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet