MCID: CHR098
MIFTS: 44

Chronic Pyelonephritis malady

Summaries for Chronic Pyelonephritis

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32MalaCards
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MalaCards: Chronic Pyelonephritis is related to pyelonephritis and hypertension. An important gene associated with Chronic Pyelonephritis is UMOD (uromodulin), and among its related pathways are Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters and Endosomal/Vacuolar pathway. The compounds uric acid and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Chronic Pyelonephritis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

chronic pyelonephritis 8 44 60


External Ids:

Disease Ontology8 DOID:1076
ICD9CM27 590.0

Related Diseases for Chronic Pyelonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Pyelonephritis family:

Acute Pyelonephritis chronic pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis31.7CPN1, UMOD, B2M, CD79A, NAGLU
2hypertension30.9CALCA, CD79A, ALB
3acute pyelonephritis30.8NAGLU
4glomerulonephritis30.5ALB, NAGLU, CD79A, B2M, UMOD
5hydronephrosis30.4NAGLU
6nephrotic syndrome30.4ALB, NAGLU, CD79A, B2M
7proteinuria30.4ALB, NAGLU, CD79A, B2M, UMOD
8chronic kidney failure30.3HLA-A, B2M, CD79A, NAGLU, ALB, UMOD
9bacteriuria30.2UMOD
10prostatitis30.2CD79A
11multiple myeloma29.9B2M
12neutropenia29.9CP
13bronchitis29.9CD79A
14uremia29.9B2M, ALB
15essential hypertension29.9ALB, NAGLU, LPXN
16hepatitis29.9HLA-A, CP
17acute kidney failure29.9UMOD, B2M, NAGLU, ALB
18proliferative glomerulonephritis29.9CD79A
19amyloidosis29.9ALB, CD79A, B2M
20myeloma29.9UMOD, B2M, CD79A, NAGLU, ALB
21tuberculosis29.9HLA-A, CD79A, ALB, CP
22diabetes mellitus29.9CP, CALCA, UMOD, HLA-A, B2M, CD79A
23malignant hypertension10.3
24kidney hypertrophy10.2
25renal hypertension10.2
26urethritis10.1
27nephrosclerosis10.1
28vesicoureteral reflux10.1
29interstitial nephritis10.1
30malignant secondary hypertension10.1
31nephrolithiasis10.0UMOD
32gout10.0UMOD
33myocardial infarction10.0NAGLU
34ischemia10.0NAGLU
35acute myocardial infarction10.0NAGLU
36arthropathy10.0B2M
37hypercholesterolemia10.0LPXN
38osteitis fibrosa10.0B2M
39wilson disease10.0CP
40cholangitis10.0ALB
41insulin resistance10.0ALB
42protein-energy malnutrition10.0ALB
43intestinal pseudo-obstruction10.0B2M
44pancreatitis10.0ALB
45goiter10.0CALCA
46crohn's disease10.0ALB
47lupus erythematosus10.0CD79A
48protein-losing enteropathy10.0ALB
49nephrocalcinosis10.0UMOD, NAGLU
50lung cancer10.0ALB

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to chronic pyelonephritis

Clinical Features for Chronic Pyelonephritis

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Drugs & Therapeutics for Chronic Pyelonephritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Chronic Pyelonephritis

Search NIH Clinical Center for Chronic Pyelonephritis

Search CenterWatch for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

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Anatomical Context for Chronic Pyelonephritis

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32MalaCards
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MalaCards organs/tissues related to Chronic Pyelonephritis:

32
Kidney, Testes, Prostate, Liver, Cortex, Ovary, Spinal cord, Lymph node, Spleen

Animal Models for Chronic Pyelonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chronic Pyelonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.6NAGLU, UMOD
2MP:00053767.3CP, ALB, CD79A, HCCS, B2M, UMOD

Publications for Chronic Pyelonephritis

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Sources:
50PubMed
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Articles related to Chronic Pyelonephritis:

(show top 50)    (show all 287)
idTitleAuthorsYear
1
Acute bacterial pyelonephritis resulting in acute kidney failure: a complication of chronic non-steroidal anti-inflammatory drug use? (19335847)
2009
2
Erythropoiesis and iron metabolism biorhythms in children with chronic pyelonephritis. (19240844)
2008
3
Chronic pyelonephritis presenting as multiple tumor-like renal lesions. (17575382)
2007
4
The bioregulatory therapy of patients with chronic pyelonephritis]. (9381626)
1997
5
Urinary excretion of prostanoids in children with chronic pyelonephritis. (9547653)
1997
6
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
7
Coexisting renal cell carcinoma and xanthogranulomatous pyelonephritis in a chronic calculous disease. (1413313)
1992
8
Systemic amyloidosis (type AA) in end-stage renal failure patients due to chronic pyelonephritis. (1758552)
1991
9
Nephrectomy in unilateral chronic pyelonephritis. A long-term follow-up study. (2210973)
1990
10
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. (2680194)
1989
11
Peripheral lymphocyte subsets in human chronic pyelonephritis. (3489575)
1986
12
The role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis. (2412354)
1985
13
Protection against chronic pyelonephritis in rats by suppression of acute suppuration: effect of colchicine and neutropenia. (7108272)
1982
14
Alpha 1-antitrypsin and antithrombin III in atrophic nephrons of chronic pyelonephritis. (6807052)
1982
15
Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. (633491)
1978
16
Unilateral chronic pyelonephritis and hypertension: coincidental or causal relationship? (717416)
1978
17
Nephrotic syndrome secondary to chronic pyelonephritis and ureterovesical reflux. (1246101)
1976
18
Case history: chronic pyelonephritis through pregnancy. (4488372)
1973
19
Nephrotic syndrome in cases of chronic pyelonephritis. (4635952)
1972
20
Bacteriuria, chronic pyelonephritis and leprosy. (4676731)
1972
21
Treatment of chronic pyelonephritis with urovalidin. (4669645)
1972
22
The renal cortex index and its value in the diagnosis of chronic pyelonephritis. (5004021)
1971
23
Chronic pyelonephritis. (A clinicopathological study). (5122794)
1971
24
Renal tubular function during transition from hydropenia to water diuresis in healthy subjects and in patients with chronic pyelonephritis. (5442943)
1970
25
Corticosteroid provocative test in chronic pyelonephritis. (5509034)
1970
26
The epidemiology of urinary infections in Hiroshima, Japan and their relation to blood pressure levels and chronic pyelonephritis. (5820487)
1969
27
Effect of water diuresis on chronic pyelonephritis. (5659542)
1968
28
Infectious and immune synergistic factors in tissue injury. Parallels between chronic obstructive respiratory disease and chronic pyelonephritis. (5673859)
1968
29
A study of the renal vascular patterns in hypertension, chronic pyelonephritis and other diseases. Hunterian Lecture delivered at the Royal College of Surgeons of England on 24th February 1966. (6021560)
1967
30
POTASSIUM DEFICIENCY AND CHRONIC PYELONEPHRITIS. (14260141)
1965
31
PATHOGENESIS OF CHRONIC PYELONEPHRITIS. II. EFFECT OF REPETITIVE INFECTION. (14223578)
1964
32
ROLE OF CHRONIC PYELONEPHRITIS IN THE PRODUCTION OF EXPERIMENTAL HYDRONEPHROSIS. (14226454)
1964
33
PATHOGENESIS OF CHRONIC PYELONEPHRITIS. STUDIES OF NONOBSTRUCTIVE ENTEROCOCCAL PYELONEPHRITIS IN THE RAT. (14155020)
1964
34
Presentation and diagnosis of chronic pyelonephritis. (13928854)
1963
35
A new concept of the pathophysiology and treatment of chronic pyelonephritis. (13983803)
1963
36
THE RELATIONSHIP OF NON-OBSTRUCTIVE REFLUX AND CHRONIC PYELONEPHRITIS: AN EXPERIMENTAL STUDY. (14063372)
1963
37
Long-term study of blood pressure in rabbits with unilateral chronic pyelonephritis or unilateral hydronephrosis. (14488507)
1962
38
Chronic pyelonephritis. (14454413)
1962
39
Chronic Pyelonephritis, Chronic Interstitial Nephritis and Phenacetin Toxicity. (20327014)
1962
40
Problems of chronic pyelonephritis. (13711803)
1961
41
Chronic pyelonephritis and vesico-ureteric reflex. (13714877)
1960
42
Significance of some renal function tests in the early diagnosis of chronic pyelonephritis. (14404627)
1959
43
Unilateral renal function in chronic pyelonephritis and renal papillary necrosis; a study on the function of the separate kidneys with the aid of selective renal clearance and renal vein catheterization. (13558903)
1958
44
Chronic pyelonephritis. (13649247)
1958
45
Chronic pyelonephritis with xanthogranulomatous change; report of 3 cases. (13248828)
1955
46
Discussion on chronic pyelonephritis. (13194642)
1954
47
Erythrophagocytosis and hemosiderosis in lymph nodes, spleen and liver in patients dying of malignant hypertension, chronic glomerulonephritis and pyelonephritis and polycystic disease. (13125214)
1954
48
Polymyxin B in chronic pyelonephritis: observations on the safety of the drug and on its influence on the renal infection. (13030476)
1953
49
WEEKLY clinicopathological exercises: right subdural hematoma with chronic pyelonephritis and nephrosclerosis. (13063704)
1953
50
Chronic pyelonephritis. (18917611)
1947

Genetic Variations for Chronic Pyelonephritis

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Expression for genes affiliated with Chronic Pyelonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Pyelonephritis

Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for genes affiliated with Chronic Pyelonephritis

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53Reactome
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Compounds for genes affiliated with Chronic Pyelonephritis

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1uric acid44 2411.3B2M, UMOD
2sialic acid4410.3NAGLU, UMOD
399mtc-dmsa4410.1B2M, NAGLU
4amikacin4410.1B2M, NAGLU
5vitamin a44 11 2412.0NAGLU, CP
6tobramycin4410.0B2M, NAGLU
7fosfomycin4410.0B2M, NAGLU
8aluminium44 1110.9B2M, NAGLU
9dmsa449.9B2M, CALCA, NAGLU
10mesna449.9NAGLU, B2M
113-Indolebutyric Acid119.8B2M, HLA-A
12mannitol44 1110.8NAGLU, ALB
13galactose449.7UMOD, CD79A
14polyether sulfone449.7ALB, B2M
15pmma449.6CALCA, CD79A, B2M
1651-cr-edta449.6ALB, B2M
17neopterin449.5CD79A, B2M, NAGLU
18iopentol449.5ALB, NAGLU, B2M
19p-aminohippuric acid449.5NAGLU, B2M, ALB
20carbamazepine44 49 1111.5NAGLU, CD79A, CP
21iohexol449.5ALB, NAGLU, B2M
22inulin449.4B2M, NAGLU, ALB
23sevoflurane44 1110.4B2M, NAGLU, ALB
24fluoride449.4NAGLU, CALCA, CD79A, B2M
25isoflurane44 1110.3CALCA, ALB, NAGLU
26furosemide44 49 59 28 11 2414.3CALCA, NAGLU, ALB
27heparin44 28 11 2412.3CD79A, UMOD, CP, NAGLU
2825-hydroxyvitamin d449.3ALB, CALCA, B2M
29icodextrin44 1110.2B2M, ALB
30cellulose acetate449.2B2M, ALB, CD79A
31urea44 11 2411.1B2M, NAGLU, ALB, UMOD
32vitamin-e449.1CP, NAGLU, B2M
33phosphorus449.1ALB, NAGLU, B2M, CALCA
34phenytoin44 49 28 1111.9CD79A, ALB, CP
35hyaluronic acid44 249.9CD79A, ALB, NAGLU, B2M
36captopril44 28 49 59 1112.8CALCA, B2M, CD79A, ALB
37vitamin b12448.8B2M, CP, ALB, CD79A
38folate448.7CD79A, ALB, CP, B2M
39cyclosporin a44 28 5910.7NAGLU, CD79A, B2M, CALCA, HLA-A
40tacrolimus44 49 1110.6HLA-A, NAGLU, CD79A, ALB
41citrate448.5NAGLU, ALB, CP, UMOD, CD79A
42thyroxine44 249.4CALCA, B2M, CD79A, ALB, CP
43indomethacin44 59 28 1111.4CP, ALB, B2M, CD79A, CALCA
44cholesterol44 28 11 2411.3ALB, LPXN, B2M, CP, NAGLU
45testosterone44 59 11 2411.2ALB, CP, CALCA, B2M, CD79A
46cysteine448.1B2M, CP, ALB, NAGLU, CD79A, UMOD
47vitamin d448.1CALCA, B2M, CD79A, CP, ALB, NAGLU
48lactate448.1CALCA, B2M, CP, ALB, CD79A, NAGLU
49alanine447.8HLA-A, B2M, CD79A, NAGLU, ALB, CP
50creatinine447.8CD79A, CALCA, UMOD, B2M, NAGLU, ALB

GO Terms for genes affiliated with Chronic Pyelonephritis

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16Gene Ontology
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Cellular components related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.5B2M, HLA-A
2extracellular spaceGO:0056157.5CP, CPN1, ALB, B2M, UMOD, CALCA

Biological processes related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.5B2M, HLA-A
2regulation of defense response to virus by virusGO:0506909.5B2M, HLA-A
3positive regulation of T cell mediated cytotoxicityGO:0019169.4B2M, HLA-A
4response to organic substanceGO:0100339.1ALB, UMOD

Products for genes affiliated with Chronic Pyelonephritis

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  • Antibodies
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Sources for Chronic Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet