MCID: CHR098
MIFTS: 37

Chronic Pyelonephritis malady

Summaries for Chronic Pyelonephritis

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33MalaCards
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MalaCards: Chronic Pyelonephritis is related to acute pyelonephritis and nephritis. An important gene associated with Chronic Pyelonephritis is UMOD (uromodulin), and among its related pathways are Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters and Endosomal/Vacuolar pathway. The compounds uric acid and sialic acid have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Chronic Pyelonephritis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

chronic pyelonephritis 8 45 61


External Ids:

Disease Ontology8 DOID:1076
ICD9CM27 590.0

Related Diseases for Chronic Pyelonephritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the pyelonephritis family:

acute pyelonephritis chronic pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1acute pyelonephritis30.8NAGLU
2nephritis30.5ALB, CD79A, B2M
3hydronephrosis30.4NAGLU
4bacteriuria30.2UMOD
5bronchitis30.0CD79A
6uremia30.0B2M, ALB
7acute kidney failure30.0UMOD, B2M, NAGLU, ALB
8proliferative glomerulonephritis30.0CD79A
9amyloidosis30.0ALB, CD79A, B2M
10tuberculosis30.0HLA-A, CD79A, ALB, CP
11n syndrome10.3
12kidney hypertrophy10.2
13nephrosclerosis10.2
14kidney papillary necrosis10.0
15xanthogranulomatous pyelonephritis10.0
16eclampsia10.0
17cellulitis10.0
18renal glycosuria10.0
19malignant essential hypertension10.0
20rickets10.0
21necrotizing fasciitis10.0
22vesicoureteral reflux10.0
23mucinous adenocarcinoma10.0
24renal pelvis adenocarcinoma10.0
25bronchopneumonia10.0
26addison's disease10.0
27adenocarcinoma10.0
28arteriosclerosis10.0
29vascular disease10.0
30pediatric hypertension10.0
31adrenocortical insufficiency10.0
32amyloidosis, renal10.0
33nephrolithiasis10.0UMOD
34gout10.0UMOD
35multiple myeloma10.0B2M
36myocardial infarction10.0NAGLU
37ischemia10.0NAGLU
38acute myocardial infarction10.0NAGLU
39arthropathy10.0B2M
40hypercholesterolemia10.0LPXN
41osteitis fibrosa10.0B2M
42wilson disease10.0CP
43cholangitis10.0ALB
44insulin resistance10.0ALB
45protein-energy malnutrition10.0ALB
46neutropenia10.0CP
47intestinal pseudo-obstruction10.0B2M
48pancreatitis10.0ALB
49goiter10.0CALCA
50crohn's disease10.0ALB

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to chronic pyelonephritis

Clinical Features for Chronic Pyelonephritis

Drugs & Therapeutics for Chronic Pyelonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Chronic Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Chronic Pyelonephritis

Search NIH Clinical Center for Chronic Pyelonephritis

Search CenterWatch for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

Anatomical Context for Chronic Pyelonephritis

Animal Models for Chronic Pyelonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Chronic Pyelonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.6NAGLU, UMOD
2MP:00053767.3CP, ALB, CD79A, HCCS, B2M, UMOD

Publications for Chronic Pyelonephritis

Sources:
51PubMed
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Articles related to Chronic Pyelonephritis:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Recurrent eclampsia in a woman with chronic pyelonephritis. (11165745)
2001
2
Massive proteinuria in a patient with chronic pyelonephritis. (10831663)
2000
3
Role of IL-8 and defensins in pathogenesis of chronic glomerulonephritis and pyelonephritis]. (10515041)
1999
4
Effect of haemodialysis on peripheral lymphocyte carnitine levels in patients with chronic pyelonephritis. (10824328)
1999
5
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
6
Atubular glomeruli in patients with chronic pyelonephritis. (2332970)
1990
7
Hypertension in chronic pyelonephritis. (3568676)
1987
8
Sensitivity of 99mtechnetium-dimercaptosuccinic acid for the diagnosis of chronic pyelonephritis: clinical and theoretical considerations. (3007785)
1986
9
Management of unilateral chronic pyelonephritis. (3981524)
1985
10
Identical twins with identical vesicoureteric reflux: chronic pyelonephritis in one. (6404409)
1983
11
Chronic granulomatous disease presenting as xanthogranulomatous pyelonephritis in late childhood. (6799633)
1982
12
Immunopathology of the glomerular changes in chronic pyelonephritis. (386707)
1979
13
Study of renal protein excretion in chronic pyelonephritis. (380900)
1979
14
Radionuclide imaging in the assessment of primary chronic pyelonephritis. (472292)
1979
15
The treatment of chronic pyelonephritis with carindacillin. (350490)
1978
16
Pediatric hypertension as a delayed sequela of reflux-induced chronic pyelonephritis. (916066)
1977
17
Long-term study of humoral immune response in patients with chronic pyelonephritis. (788977)
1976
18
The occurrence of mycoplasmas in the urinary tract of patients with chronic pyelonephritis. (1130197)
1975
19
Experimental lipid A-induced nephritis in the dog. A possible role of lipid A in the pathogenesis of abacterial chronic pyelonephritis. (4613655)
1974
20
The inability to diagnose chronic pyelonephritis on the excretory urogram in adults. (4823961)
1974
21
Chronic pyelonephritis and renal medullary necrosis. (5155285)
1971
22
Observations on vesicoureteral reflux and chronic pyelonephritis in adults. (5430799)
1970
23
Selective aldosterone deficiency in chronic pyelonephritis. (5495285)
1970
24
Patterns of proteinuria in chronic pyelonephritis. The pseudo-glomerular pattern. (4179441)
1969
25
The intrarenal vascular alterations in experimental chronic pyelonephritis and their relationship to the development of hypertension. (4192560)
1969
26
Use of furosemide for evaluation of the urinary concentrating mechanism in chronic pyelonephritis. (5666928)
1968
27
Alkaline phosphatase activity in dialysed urine samples from patients with normal pregnancy, toxemia of pregnancy and chronic pyelonephritis. (5720439)
1968
28
Renal content of renin-like material and pressor reactivity of rats with chronic pyelonephritis. (4290269)
1967
29
Chronic pyelonephritis at autopsy. (6023536)
1967
30
Chronic pyelonephritis: relative incidence in transplant recipients. (5330923)
1966
31
THE PREVENTION OF CHRONIC PYELONEPHRITIS. (14269347)
1965
32
POTASSIUM DEPLETION AND CHRONIC PYELONEPHRITIS. (14124095)
1964
33
LONG-TERM FOLLOW-UP ON THE NITROFURANTOIN TREATMENT OF PATIENTS WITH CHRONIC PYELONEPHRITIS. (14288006)
1964
34
CHRONIC PYELONEPHRITIS AND THE ANTIBIOTICS. (14062883)
1963
35
Problems of chronic pyelonephritis. (13974947)
1963
36
Experimental pyelonephritis: nephron dissection of the kidney of experimental chronic pyelonephritis in the rabbit. (13988519)
1963
37
Reflux as a cause of hydronephrosis and chronic pyelonephritis. (14450229)
1962
38
Research on chronic pyelonephritis during the first ten years of the Institute for Cardiovascular Research. (14488510)
1962
39
Chronic pyelonephritis (a clinico-pathological study). (14037405)
1962
40
Chronic pyelonephritis. (13756007)
1961
41
A genetic study of blood pressure in chronic pyelonephritis. (13718655)
1961
42
Chronic pyelonephritis. (13668710)
1959
43
Chronic pyelonephritis. (13333099)
1956
44
Hematogenous pyelonephritis in rats. II. Production of chronic pyelonephritis by Escherichia coli. (13297697)
1956
45
WEEKLY clinicopathological exercises; acute and chronic pyelonephritis. (13036988)
1953
46
Chronic pyelonephritis: an important cause of hypertension. (13003668)
1952
47
WEEKLY clinicopathological exercises: chronic pyelonephritis severe (with uremia); atrophy of the right kidney, hypertrophy of left; bronchopneumonia; aortic arteriosclerosis, severe, ascending arch, with short localized dissection; calcareous aortic stenosis. (14863577)
1951
48
Unilateral renal glycosuria in association with diabetes mellitus and chronic pyelonephritis. (15426107)
1950
49
Chronic pyelonephritis. (18862271)
1948
50
Acute and chronic pyelonephritis]. (20261472)
1947

Genetic Variations for Chronic Pyelonephritis

Expression for genes affiliated with Chronic Pyelonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Pyelonephritis

Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for genes affiliated with Chronic Pyelonephritis

Sources:
54Reactome
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Compounds for genes affiliated with Chronic Pyelonephritis

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1uric acid45 2411.3B2M, UMOD
2sialic acid4510.3UMOD, NAGLU
399mtc-dmsa4510.1B2M, NAGLU
4amikacin4510.1B2M, NAGLU
5vitamin a45 11 2412.0NAGLU, CP
6tobramycin4510.0B2M, NAGLU
7fosfomycin4510.0B2M, NAGLU
8aluminium45 1110.9B2M, NAGLU
9dmsa459.9NAGLU, B2M, CALCA
10mesna459.9B2M, NAGLU
113-Indolebutyric Acid119.8HLA-A, B2M
12mannitol45 1110.8ALB, NAGLU
13galactose459.7CD79A, UMOD
14polyether sulfone459.7ALB, B2M
15pmma459.6CALCA, B2M, CD79A
1651-cr-edta459.6ALB, B2M
17neopterin459.5NAGLU, CD79A, B2M
18iopentol459.5ALB, NAGLU, B2M
19p-aminohippuric acid459.5B2M, NAGLU, ALB
20carbamazepine45 50 1111.5CD79A, NAGLU, CP
21iohexol459.5B2M, NAGLU, ALB
22inulin459.4B2M, NAGLU, ALB
23sevoflurane45 1110.4ALB, NAGLU, B2M
24fluoride459.4CALCA, B2M, CD79A, NAGLU
25isoflurane45 1110.3ALB, NAGLU, CALCA
26furosemide45 50 60 29 11 2414.3CALCA, NAGLU, ALB
27heparin45 29 11 2412.3CP, NAGLU, CD79A, UMOD
2825-hydroxyvitamin d459.3ALB, B2M, CALCA
29icodextrin45 1110.2ALB, B2M
30cellulose acetate459.2ALB, CD79A, B2M
31urea45 11 2411.1ALB, NAGLU, B2M, UMOD
32vitamin-e459.1CP, NAGLU, B2M
33phosphorus459.1ALB, NAGLU, B2M, CALCA
34phenytoin45 50 29 1111.9CP, ALB, CD79A
35hyaluronic acid45 249.9B2M, CD79A, NAGLU, ALB
36captopril45 29 50 60 1112.8CALCA, B2M, CD79A, ALB
37vitamin b12458.8CP, ALB, CD79A, B2M
38folate458.7B2M, CD79A, ALB, CP
39cyclosporin a45 29 6010.7CALCA, HLA-A, B2M, CD79A, NAGLU
40tacrolimus45 50 1110.6HLA-A, CD79A, NAGLU, ALB
41citrate458.5CP, ALB, NAGLU, CD79A, UMOD
42thyroxine45 249.4CALCA, B2M, CD79A, ALB, CP
43indomethacin45 60 29 1111.4CALCA, B2M, CD79A, ALB, CP
44cholesterol45 29 11 2411.3LPXN, B2M, NAGLU, ALB, CP
45testosterone45 60 11 2411.2CALCA, B2M, CD79A, ALB, CP
46cysteine458.1UMOD, B2M, CD79A, NAGLU, ALB, CP
47vitamin d458.1CALCA, B2M, CD79A, NAGLU, ALB, CP
48lactate458.1CALCA, B2M, CD79A, NAGLU, ALB, CP
49alanine457.8HLA-A, B2M, CD79A, NAGLU, ALB, CP
50creatinine457.8CP, CALCA, UMOD, B2M, CD79A, NAGLU

GO Terms for genes affiliated with Chronic Pyelonephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.5B2M, HLA-A
2extracellular spaceGO:0056157.5CP, CPN1, ALB, B2M, UMOD, CALCA

Biological processes related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.5B2M, HLA-A
2regulation of defense response to virus by virusGO:0506909.5B2M, HLA-A
3positive regulation of T cell mediated cytotoxicityGO:0019169.4B2M, HLA-A
4response to organic substanceGO:0100339.1ALB, UMOD

Products for genes affiliated with Chronic Pyelonephritis

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Sources for Chronic Pyelonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet