MCID: CHR098
MIFTS: 47

Chronic Pyelonephritis malady

Nephrological diseases category
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Summaries for Chronic Pyelonephritis

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33MalaCards
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MalaCards: Chronic Pyelonephritis is related to pyelonephritis and hypertension. An important gene associated with Chronic Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are TCR signaling in naive CD4+ T cells and Downstream signaling in naive CD8+ T cells. The compounds 99mtc-dmsa and amikacin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and cortex, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Classifications for Chronic Pyelonephritis

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Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

chronic pyelonephritis 8 45 62


External Ids:

Disease Ontology8 DOID:1076
ICD9CM27 590.0

Related Diseases for Chronic Pyelonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Pyelonephritis family:

Acute Pyelonephritis chronic pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis31.9B2M, NAGLU, UMOD, CD79A
2hypertension31.0CD79A, ALB, CALCA
3nephritis30.6CD79A, ALB, B2M
4glomerulonephritis30.5CD79A, ALB, UMOD, NAGLU, B2M
5nephrotic syndrome30.5CD79A, ALB, NAGLU, B2M
6bacteriuria30.4UMOD
7prostatitis30.4CD79A
8proteinuria30.4B2M, NAGLU, UMOD, ALB, CD79A
9vesicoureteral reflux30.4NAGLU, UMOD
10cystitis30.2NAGLU, UMOD
11uremia30.1ALB, B2M
12bronchitis30.1NAGLU, CP
13amyloidosis30.0B2M, ALB, CD79A
14hepatitis30.0ALB, HLA-A
15myeloma30.0B2M, NAGLU, UMOD, ALB, CD79A
16tuberculosis29.9HLA-A, CP, ALB, CD79A
17chronic kidney failure29.8HLA-A, B2M, NAGLU, UMOD, ALB, CD79A
18diabetes mellitus29.7HLA-A, B2M, CP, NAGLU, UMOD, CALCA
19hydronephrosis10.3
20malignant hypertension10.3
21urethritis10.2
22nephrosclerosis10.2
23interstitial nephritis10.2
24osteitis fibrosa10.1B2M
25protein-losing enteropathy10.1ALB
26hyperthyroxinemia10.1ALB
27hepatorenal syndrome10.1ALB
28acute poststreptococcal glomerulonephritis10.1CD79A
29gastroenteritis10.1CD79A
30hemosiderosis10.1CP
31acute kidney tubular necrosis10.1NAGLU, UMOD
32urinary system disease10.1B2M, NAGLU
33fallopian tube cancer10.1B2M, NAGLU
34nephrocalcinosis10.1NAGLU, UMOD
35pseudohypoparathyroidism10.1NAGLU, CALCA
36paget's disease of bone10.1B2M, CALCA
37hypoparathyroidism10.1NAGLU, CALCA
38hypophosphatemia10.1B2M, CALCA
39macroglobulinemia10.1B2M, CD79A
40urinary tract obstruction10.1B2M, NAGLU, UMOD
41plasmacytoma10.1B2M, CD79A
42acquired immunodeficiency syndrome10.1ALB, B2M
43hemochromatosis10.0CP, B2M
44peripheral vascular disease10.0CD79A, ALB
45thyroiditis10.0CALCA, CD79A
46membranous glomerulonephritis10.0ALB, CD79A
47metabolic acidosis10.0B2M, ALB
48peritonitis10.0B2M, ALB
49hyperparathyroidism10.0ALB, CALCA
50acute liver failure10.0CP, ALB

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to chronic pyelonephritis

Symptoms for Chronic Pyelonephritis

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Drugs & Therapeutics for Chronic Pyelonephritis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

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Anatomical Context for Chronic Pyelonephritis

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33MalaCards
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MalaCards organs/tissues related to Chronic Pyelonephritis:

33
Kidney, Testes, Cortex, Prostate, Spinal cord, Liver, Ovary

Animal Models for Chronic Pyelonephritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Chronic Pyelonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5CD79A, UMOD, NAGLU, CP, B2M
2MP:00053708.1B2M, CP, NAGLU, ALB
3MP:00053678.1CD79A, ALB, CALCA, UMOD, NAGLU
4MP:00053767.4B2M, CP, UMOD, CALCA, ALB, CD79A

Publications for Chronic Pyelonephritis

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52PubMed
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Articles related to Chronic Pyelonephritis:

(show top 50)    (show all 276)
idTitleAuthorsYear
1
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
2
Computed tomography evaluation of renal parenchymal volume in patients with chronic pyelonephritis and its relationship to glomerular filtration rate. (7735742)
1995
3
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
4
The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. (7532880)
1994
5
Atubular glomeruli in patients with chronic pyelonephritis. (2332970)
1990
6
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. (2680194)
1989
7
P-fimbriae receptors in patients with chronic pyelonephritis. (2896254)
1988
8
Auto-antibody to kidney tubular cells during retrograde chronic pyelonephritis in rats. (3885065)
1985
9
Role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis. (3912177)
1985
10
Immunopathology of the glomerular changes in chronic pyelonephritis. (386707)
1979
11
Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. (633491)
1978
12
Long-term study of humoral immune response in patients with chronic pyelonephritis. (788977)
1976
13
Diagnostic value of ceruloplasmin, haptoglobin and sialic acid in chronic pyelonephritis. (965209)
1976
14
Hypertension in children with chronic pyelonephritis. (1059804)
1975
15
The occurrence of mycoplasmas in the urinary tract of patients with chronic pyelonephritis. (1130197)
1975
16
Letter: Urinary reflux and chronic pyelonephritis. (46073)
1975
17
The incidence of chronic pyelonephritis in schistosomal hepatic fibrosis utilising the prednisolone provocation test. (4726339)
1973
18
Improved treatment of chronic pyelonephritis with nitrofurantoin in combination with deglycyrrhizinated liquorice. (4556768)
1972
19
What is chronic pyelonephritis? (5551266)
1971
20
Chronic pyelonephritis and renal medullary necrosis. (5155285)
1971
21
Medical management of chronic pyelonephritis: acute and chronic. (5428975)
1970
22
Effect of water diuresis on chronic pyelonephritis. (5659542)
1968
23
Chronic pyelonephritis: relative incidence in transplant recipients. (5330923)
1966
24
Asymmetry of renal function with special references to chronic pyelonephritis. (5220569)
1966
25
UROLOGICAL SURVEY OF CHRONIC PYELONEPHRITIS AND RECURRENT URINARY INFECTION WITHOUT OBSTRUCTION. (14269350)
1965
26
A NEW ANTIMICROBIAL AGENT, NEGGRAM, USED IN CHRONIC PYELONEPHRITIS. (14340960)
1965
27
PATHOGENESIS OF CHRONIC PYELONEPHRITIS. II. EFFECT OF REPETITIVE INFECTION. (14223578)
1964
28
ROLE OF CHRONIC PYELONEPHRITIS IN THE PRODUCTION OF EXPERIMENTAL HYDRONEPHROSIS. (14226454)
1964
29
POTASSIUM DEPLETION AND CHRONIC PYELONEPHRITIS. (14124095)
1964
30
CHRONIC PYELONEPHRITIS AND THE ANTIBIOTICS. (14062883)
1963
31
Long-term treatment of chronic pyelonephritis in children. (13955227)
1963
32
Presentation and diagnosis of chronic pyelonephritis. (13928854)
1963
33
Problems of chronic pyelonephritis. (13974947)
1963
34
Multiple-antibiotic-resistant enteric bacilli in chronic pyelonephritis. A one-year study in the Philippine General Hospital. (14465338)
1962
35
The finding of chronic pyelonephritis in males and females at autopsy. (13756618)
1960
36
Hematogenous pyelonephritis in rats. IV. Relationship of bacterial species to the pathogenesis and sequelae of chronic pyelonephritis. (13664797)
1959
37
Chronic pyelonephritis lenta and the "malignant phase of hypertension". (14441666)
1959
38
Chronic pyelonephritis. (13668710)
1959
39
Unilateral renal function in chronic pyelonephritis and renal papillary necrosis; a study on the function of the separate kidneys with the aid of selective renal clearance and renal vein catheterization. (13558903)
1958
40
The pathogenesis of chronic pyelonephritis. (13610072)
1958
41
Hyperchloremic acidosis in chronic pyelonephritis. (13552915)
1958
42
Chronic pyelonephritis with xanthogranulomatous change; report of 3 cases. (13248828)
1955
43
Chronic pyelonephritis. (13131022)
1954
44
Polymyxin B in chronic pyelonephritis: observations on the safety of the drug and on its influence on the renal infection. (13030476)
1953
45
WEEKLY clinicopathological exercises; ectopic left kidney (in pelvis) with chronic pyelonephritis; congenital absence of right kidney, ovary & salpinx. (14890819)
1952
46
Clinico-pathological conference: hypoplasia of the kidneys secondary to chronic pyelonephritis; acute bronchitis; myocardial hypertrophy; fatty metamorphosis of the liver; rickets. (14870327)
1951
47
Chronic pyelonephritis simulating Addison's disease. (15413207)
1950
48
Chronic pyelonephritis and hypertension. (14795114)
1950
49
Pregnancy following lumbodorsal splanchnicectomy for essential and malignant hypertension and hypertension associated with chronic pyelonephritis. (20241256)
1947
50
Duodenal obstruction caused by chronic pyelonephritis and hydronephrosis. (21014787)
1946

Variations for Chronic Pyelonephritis

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Expression for genes affiliated with Chronic Pyelonephritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Pyelonephritis

Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for genes affiliated with Chronic Pyelonephritis

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 53QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Chronic Pyelonephritis

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
199mtc-dmsa4510.0NAGLU, B2M
2amikacin4510.0NAGLU, B2M
3fosfomycin459.9NAGLU, B2M
4tobramycin459.9NAGLU, B2M
5dmsa459.8B2M, NAGLU, CALCA
6aluminium45 1110.7B2M, NAGLU
7pmma459.6CD79A, CALCA, B2M
8polyether sulfone459.5B2M, ALB
9neopterin459.5CD79A, NAGLU, B2M
10mesna459.5NAGLU, B2M
1151-cr-edta459.5ALB, B2M
12iopentol459.4NAGLU, B2M, ALB
13p-aminohippuric acid459.4NAGLU, B2M, ALB
14inulin459.4ALB, NAGLU, B2M
15iohexol459.4ALB, NAGLU, B2M
16fluoride459.3NAGLU, B2M, CALCA, CD79A
17sevoflurane51 45 1111.3B2M, NAGLU, ALB
18galactose459.3UMOD, CD79A, B2M
19isoflurane51 45 1111.3NAGLU, CALCA, ALB
20vitamin-e459.3CP, NAGLU, B2M
21gamma globulin459.2ALB, CD79A, B2M
22sialic acid459.2CP, NAGLU, UMOD, CD79A
23furosemide45 61 29 51 24 1114.2NAGLU, CALCA, ALB
2425-hydroxyvitamin d459.2ALB, CALCA, B2M
25cellulose acetate459.2ALB, B2M, CD79A
26urea45 24 1111.0B2M, NAGLU, UMOD, ALB
27phosphorus459.0ALB, B2M, NAGLU, CALCA
28carbamazepine45 51 1111.0CD79A, NAGLU, HLA-A, CP
29phenytoin45 51 29 1111.9CD79A, ALB, CP
30hyaluronic acid45 249.9NAGLU, ALB, CD79A, B2M
31captopril45 61 51 29 1112.8B2M, CALCA, ALB, CD79A
32mannitol45 119.8NAGLU, ALB, CP, B2M
33vitamin a45 24 1110.8ALB, B2M, CP, NAGLU
34vitamin b12458.7CD79A, ALB, B2M, CP
35cyclosporin a45 29 6110.7CD79A, CALCA, NAGLU, B2M, HLA-A
36folate458.7CD79A, B2M, ALB, CP
37tacrolimus45 51 1110.6HLA-A, CD79A, ALB, NAGLU
38uric acid45 249.5B2M, CP, NAGLU, UMOD, ALB
39citrate458.5ALB, CD79A, UMOD, NAGLU, CP
40heparin45 29 24 1111.4CD79A, NAGLU, UMOD, ALB, CP
41thyroxine45 249.3B2M, CP, CALCA, ALB, CD79A
42indomethacin45 29 61 1111.3CD79A, ALB, CALCA, CP, B2M
43cholesterol45 29 24 1111.2CP, B2M, ALB, LPXN, NAGLU
44testosterone45 61 24 1111.2CD79A, ALB, CALCA, B2M, CP
45glucose458.2ALB, UMOD, LPXN, NAGLU, B2M
46vitamin d458.0B2M, CP, CALCA, ALB, CD79A, NAGLU
47cysteine458.0B2M, CP, NAGLU, UMOD, ALB, CD79A
48lactate458.0NAGLU, CALCA, B2M, ALB, CD79A, CP
49alanine457.8CP, CD79A, ALB, NAGLU, B2M, HLA-A
50creatinine457.7B2M, ALB, CALCA, UMOD, NAGLU, CP

GO Terms for genes affiliated with Chronic Pyelonephritis

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16Gene Ontology
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Cellular components related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:0306709.5B2M, HLA-A
2MHC class I protein complexGO:0426129.4B2M, HLA-A
3ER to Golgi transport vesicle membraneGO:0125079.2B2M, HLA-A
4extracellular spaceGO:0056158.0B2M, CP, UMOD, CALCA, ALB
5extracellular vesicular exosomeGO:0700627.5ALB, UMOD, NAGLU, CP, B2M, HLA-A

Biological processes related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.6B2M, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.5B2M, HLA-A
3regulation of defense response to virus by virusGO:0506909.5B2M, HLA-A
4interferon-gamma-mediated signaling pathwayGO:0603339.5B2M, HLA-A
5response to organic substanceGO:0100339.2UMOD, ALB
6retina homeostasisGO:0018959.0ALB, B2M

Molecular functions related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.1ALB, CP
2chaperone bindingGO:0510878.8ALB, CP

Products for genes affiliated with Chronic Pyelonephritis

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  • Antibodies
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Sources for Chronic Pyelonephritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet