MCID: CHR098
MIFTS: 44

Chronic Pyelonephritis malady

Summaries for Chronic Pyelonephritis

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32MalaCards
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MalaCards: Chronic Pyelonephritis is related to pyelonephritis and hypertension. An important gene associated with Chronic Pyelonephritis is UMOD (uromodulin), and among its related pathways are Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters and Endosomal/Vacuolar pathway. The compounds uric acid and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Chronic Pyelonephritis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

chronic pyelonephritis 8 44 60


External Ids:

Disease Ontology8 DOID:1076
ICD9CM27 590.0

Related Diseases for Chronic Pyelonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Pyelonephritis family:

Acute Pyelonephritis chronic pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis31.7CPN1, UMOD, B2M, CD79A, NAGLU
2hypertension30.9CALCA, CD79A, ALB
3acute pyelonephritis30.8NAGLU
4glomerulonephritis30.5ALB, NAGLU, CD79A, B2M, UMOD
5hydronephrosis30.4NAGLU
6nephrotic syndrome30.4ALB, NAGLU, CD79A, B2M
7proteinuria30.4ALB, NAGLU, CD79A, B2M, UMOD
8chronic kidney failure30.3HLA-A, B2M, CD79A, NAGLU, ALB, UMOD
9bacteriuria30.2UMOD
10prostatitis30.2CD79A
11multiple myeloma29.9B2M
12neutropenia29.9CP
13bronchitis29.9CD79A
14uremia29.9B2M, ALB
15essential hypertension29.9ALB, NAGLU, LPXN
16hepatitis29.9HLA-A, CP
17acute kidney failure29.9UMOD, B2M, NAGLU, ALB
18proliferative glomerulonephritis29.9CD79A
19amyloidosis29.9ALB, CD79A, B2M
20myeloma29.9UMOD, B2M, CD79A, NAGLU, ALB
21tuberculosis29.9HLA-A, CD79A, ALB, CP
22diabetes mellitus29.9CP, CALCA, UMOD, HLA-A, B2M, CD79A
23malignant hypertension10.3
24kidney hypertrophy10.2
25renal hypertension10.2
26urethritis10.1
27nephrosclerosis10.1
28vesicoureteral reflux10.1
29interstitial nephritis10.1
30malignant secondary hypertension10.1
31nephrolithiasis10.0UMOD
32gout10.0UMOD
33myocardial infarction10.0NAGLU
34ischemia10.0NAGLU
35acute myocardial infarction10.0NAGLU
36arthropathy10.0B2M
37hypercholesterolemia10.0LPXN
38osteitis fibrosa10.0B2M
39wilson disease10.0CP
40cholangitis10.0ALB
41insulin resistance10.0ALB
42protein-energy malnutrition10.0ALB
43intestinal pseudo-obstruction10.0B2M
44pancreatitis10.0ALB
45goiter10.0CALCA
46crohn's disease10.0ALB
47lupus erythematosus10.0CD79A
48protein-losing enteropathy10.0ALB
49nephrocalcinosis10.0UMOD, NAGLU
50lung cancer10.0ALB

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to chronic pyelonephritis

Clinical Features for Chronic Pyelonephritis

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Drugs & Therapeutics for Chronic Pyelonephritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Chronic Pyelonephritis

Search NIH Clinical Center for Chronic Pyelonephritis

Search CenterWatch for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

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Anatomical Context for Chronic Pyelonephritis

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32MalaCards
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MalaCards organs/tissues related to Chronic Pyelonephritis:

32
Kidney, Testes, Prostate, Cortex, Liver, Lymph node, Spleen, Spinal cord, Ovary

Animal Models for Chronic Pyelonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chronic Pyelonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.6NAGLU, UMOD
2MP:00053767.3CP, ALB, CD79A, HCCS, B2M, UMOD

Publications for Chronic Pyelonephritis

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50PubMed
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Articles related to Chronic Pyelonephritis:

(show top 50)    (show all 287)
idTitleAuthorsYear
1
Estimation of the kidney functional reserve as the prognosis of preeclampsia development in the pregnant woman with chronic pyelonephritis and glomerulonephritis. (20614512)
2010
2
Chronic granulomatous interstitial nephritis: unusual complication of acute pyelonephritis. (8684545)
1996
3
Mechanisms of renal damage in chronic pyelonephritis (reflux nephropathy). (7614849)
1995
4
Role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis. (3912177)
1985
5
Long-term intermittent netilmicin therapy of chronic pyelonephritis: a pharmacokinetic and clinical study. (4018946)
1985
6
Detection of latent bacteriuria in patients with chronic pyelonephritis. (3989292)
1985
7
Urographic findings in adults with chronic pyelonephritis. (4064488)
1985
8
Autoimmune responses to Tamm-Horsfall protein in the pathogenesis of chronic pyelonephritis. (6545494)
1984-1985
9
Immunopathogenesis of chronic pyelonephritis. (6192715)
1983
10
Results of angiographic studies of patients with chronic pyelonephritis. (6425143)
1983
11
Measurements of nonspecific humoral immune parameters in patients with chronic pyelonephritis. (7237865)
1981
12
Chronic pyelonephritis. Electron microscopic study. III. The ureter. (112082)
1979
13
Hypertension and plasma renin activity in experimentally induced chronic pyelonephritis. (940627)
1976
14
Comparison of renal excretion of chloramphenicol in patients with chronic pyelonephritis, glomerulonephritis and polycystic kidneys. (1254381)
1976
15
Renal potassium excretion in patients with chronic pyelonephritis. (1121599)
1975
16
Editorial: Massive proteinuria associated with chronic pyelonephritis. (4767182)
1973
17
Gentamicin in acute and chronic pyelonephritis. (4544327)
1973
18
Ureteric reflux 1973: chronic pyelonephritis v. reflux nephropathy. (4580015)
1973
19
Renal excretion of gentamycin in chronic pyelonephritis. (5121528)
1971
20
The renal cortex index and its value in the diagnosis of chronic pyelonephritis. (5006197)
1971
21
Chronic pyelonephritis as a cause of renal failure in dialysis candidates. Analysis of 173 patients. (4927432)
1971
22
Medical management of chronic pyelonephritis: acute and chronic. (5428975)
1970
23
Markers for chronic pyelonephritis. (4191252)
1970
24
Maximum tubular reabsorption of water. A preliminary study of renal concentrating capacity in children with chronic pyelonephritis. (5455519)
1970
25
The incidence of chronic pyelonephritis diagnosed by renal biopsy and bacterial counts in pre-eclamptic and eclamptic women. (4919904)
1970
26
Nephrotic syndrome due to chronic pyelonephritis. (5714575)
1968
27
Long-term treatment of chronic pyelonephritis. (5655858)
1968
28
Effect of hyperbaric oxygen on chronic pyelonephritis in rats. (4874295)
1968
29
The radiological contribution toward the diagnosis of chronic pyelonephritis. (6025043)
1967
30
Long-term treatment of chronic pyelonephritis. (6037470)
1967
31
Asymmetry of renal function with special references to chronic pyelonephritis. (5220569)
1966
32
Experimental pyelonephritis. XII. Changes mimicking chronic pyelonephritis as a consequence of renal vascular occlusion in the rat. (5981347)
1966
33
COLONY COUNTS AND CHRONIC PYELONEPHRITIS. (14319460)
1965
34
Comparison of some tests used in the diagnosis of chronic pyelonephritis. (5840516)
1965
35
THE RADIOLOGY OF CHRONIC PYELONEPHRITIS. (14325643)
1965
36
CHRONIC PYELONEPHRITIS AND THE ANTIBIOTICS . (14104417)
1964
37
HYPERKALEMIA AND HYPERCHLOREMIC ACIDOSIS IN CHRONIC PYELONEPHRITIS. (14231280)
1964
38
Long-term treatment of chronic pyelonephritis in children. (13955227)
1963
39
Multiple-antibiotic-resistant enteric bacilli in chronic pyelonephritis. A one-year study in the Philippine General Hospital. (14465338)
1962
40
The nature of chronic pyelonephritis. (13931750)
1962
41
Chronic pyelonephritis in "essential" hypertension. A critical autopsy analysis. (13911127)
1962
42
The finding of chronic pyelonephritis in males and females at autopsy. (13756618)
1960
43
Intensive treatment of chronic pyelonephritis, including some observations on prolonged intra-arterial infusion of antibiotics. (14402978)
1960
44
Experimental pyelonephritis: the role of arterial narrowing in the production of the kidney of chronic pyelonephritis. (13713502)
1960
45
Hematogenous pyelonephritis in rats. IV. Relationship of bacterial species to the pathogenesis and sequelae of chronic pyelonephritis. (13664797)
1959
46
The relationship of urinary obstruction to experimental chronic pyelonephritis in the rabbit. (14434657)
1959
47
Hyperchloremic acidosis in chronic pyelonephritis. (13552915)
1958
48
Chronic pyelonephritis. (13284528)
1955
49
Chronic pyelonephritis. (13131022)
1954
50
CHRONIC PYELONEPHRITIS AND ARTERIAL HYPERTENSION. (16694535)
1937

Genetic Variations for Chronic Pyelonephritis

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Expression for genes affiliated with Chronic Pyelonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Pyelonephritis

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Pathways for genes affiliated with Chronic Pyelonephritis

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53Reactome
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Compounds for genes affiliated with Chronic Pyelonephritis

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1uric acid44 2411.3B2M, UMOD
2sialic acid4410.3NAGLU, UMOD
399mtc-dmsa4410.1B2M, NAGLU
4amikacin4410.1B2M, NAGLU
5vitamin a44 11 2412.0NAGLU, CP
6tobramycin4410.0B2M, NAGLU
7fosfomycin4410.0B2M, NAGLU
8aluminium44 1110.9B2M, NAGLU
9dmsa449.9B2M, CALCA, NAGLU
10mesna449.9NAGLU, B2M
113-Indolebutyric Acid119.8B2M, HLA-A
12mannitol44 1110.8NAGLU, ALB
13galactose449.7UMOD, CD79A
14polyether sulfone449.7ALB, B2M
15pmma449.6CALCA, CD79A, B2M
1651-cr-edta449.6ALB, B2M
17neopterin449.5CD79A, B2M, NAGLU
18iopentol449.5ALB, NAGLU, B2M
19p-aminohippuric acid449.5NAGLU, B2M, ALB
20carbamazepine44 49 1111.5NAGLU, CD79A, CP
21iohexol449.5ALB, NAGLU, B2M
22inulin449.4B2M, NAGLU, ALB
23sevoflurane44 1110.4B2M, NAGLU, ALB
24fluoride449.4NAGLU, CALCA, CD79A, B2M
25isoflurane44 1110.3CALCA, ALB, NAGLU
26furosemide44 49 59 28 11 2414.3CALCA, NAGLU, ALB
27heparin44 28 11 2412.3CD79A, UMOD, CP, NAGLU
2825-hydroxyvitamin d449.3ALB, CALCA, B2M
29icodextrin44 1110.2B2M, ALB
30cellulose acetate449.2B2M, ALB, CD79A
31urea44 11 2411.1B2M, NAGLU, ALB, UMOD
32vitamin-e449.1CP, NAGLU, B2M
33phosphorus449.1ALB, NAGLU, B2M, CALCA
34phenytoin44 49 28 1111.9CD79A, ALB, CP
35hyaluronic acid44 249.9CD79A, ALB, NAGLU, B2M
36captopril44 28 49 59 1112.8CALCA, B2M, CD79A, ALB
37vitamin b12448.8B2M, CP, ALB, CD79A
38folate448.7CD79A, ALB, CP, B2M
39cyclosporin a44 28 5910.7NAGLU, CD79A, B2M, CALCA, HLA-A
40tacrolimus44 49 1110.6HLA-A, NAGLU, CD79A, ALB
41citrate448.5NAGLU, ALB, CP, UMOD, CD79A
42thyroxine44 249.4CALCA, B2M, CD79A, ALB, CP
43indomethacin44 59 28 1111.4CP, ALB, B2M, CD79A, CALCA
44cholesterol44 28 11 2411.3ALB, LPXN, B2M, CP, NAGLU
45testosterone44 59 11 2411.2ALB, CP, CALCA, B2M, CD79A
46cysteine448.1B2M, CP, ALB, NAGLU, CD79A, UMOD
47vitamin d448.1CALCA, B2M, CD79A, CP, ALB, NAGLU
48lactate448.1CALCA, B2M, CP, ALB, CD79A, NAGLU
49alanine447.8HLA-A, B2M, CD79A, NAGLU, ALB, CP
50creatinine447.8CD79A, CALCA, UMOD, B2M, NAGLU, ALB

GO Terms for genes affiliated with Chronic Pyelonephritis

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16Gene Ontology
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Cellular components related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.5B2M, HLA-A
2extracellular spaceGO:0056157.5CP, CPN1, ALB, B2M, UMOD, CALCA

Biological processes related to Chronic Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.5B2M, HLA-A
2regulation of defense response to virus by virusGO:0506909.5B2M, HLA-A
3positive regulation of T cell mediated cytotoxicityGO:0019169.4B2M, HLA-A
4response to organic substanceGO:0100339.1ALB, UMOD

Products for genes affiliated with Chronic Pyelonephritis

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  • Antibodies
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Sources for Chronic Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet