MCID: CHR098
MIFTS: 35

Chronic Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Chronic Pyelonephritis

MalaCards integrated aliases for Chronic Pyelonephritis:

Name: Chronic Pyelonephritis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1076
ICD10 33 N11 N11.9
ICD9CM 35 590.0
NCIt 47 C123216
UMLS 69 C0085697

Summaries for Chronic Pyelonephritis

MalaCards based summary : Chronic Pyelonephritis is related to hand-foot-uterus syndrome and pyelonephritis. An important gene associated with Chronic Pyelonephritis is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Interferon gamma signaling and Antigen processing-Cross presentation. The drugs Bone Density Conservation Agents and Diphosphonates have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and adipocyte.

Related Diseases for Chronic Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 hand-foot-uterus syndrome 10.8
2 pyelonephritis 10.8
3 autosomal recessive severe congenital neutropenia due to cxcr2 deficiency 10.6 HLA-A HLA-B
4 ramsay hunt syndrome i 10.6 HLA-A HLA-B
5 cardioskeletal syndrome, kuwaiti type 10.6 HLA-A HLA-B
6 lens-induced iridocyclitis 10.6 HLA-A HLA-B
7 hernia of ovary and fallopian tube 10.6 HLA-A HLA-B
8 progressive myoclonus epilepsy 10.6 HLA-A HLA-B
9 low compliance bladder 10.6 CALCA TLR4
10 heterotaxy, visceral, 4, autosomal 10.5 HLA-A HLA-B
11 not otherwise specified 3-mga-uria type 10.5 HLA-A HLA-B
12 antigen-peptide-transporter 2 deficiency 10.5 HLA-B TLR4
13 mazabraud syndrome 10.5 HLA-A HLA-B
14 acanthoma 10.5 HLA-A HLA-B
15 high pressure neurological syndrome 10.5 CALCA HLA-B
16 hemophagocytic lymphohistiocytosis 10.5 HLA-A HLA-B
17 familial periodic paralysis 10.5 B2M HLA-A
18 hypertrophy of breast 10.5 HLA-A HLA-B
19 follicular mucinosis 10.4 HLA-A TLR4
20 anaerobic meningitis 10.4 HLA-A HLA-B
21 noma 10.4 HLA-A HLA-B
22 anal canal squamous cell carcinoma 10.4 B2M CALCA
23 spondylocostal dysostosis 4 10.4 B2M TLR4
24 acute necrotizing encephalopathy type 1 10.4 HLA-A HLA-B
25 fallopian tube leiomyoma 10.4 B2M CALCA
26 orbital osteomyelitis 10.4 HLA-A HLA-B
27 sezary's disease 10.4 HLA-A HLA-B
28 classic hairy cell leukemia 10.3 HLA-A HLA-B
29 voyeurism 10.3 HLA-A REN
30 non-congenital cyst of kidney 10.3 B2M REN
31 bladder transitional cell papilloma 10.3 CALCA CPN1
32 astrakhan spotted fever 10.2 CALCA REN
33 idiopathic juvenile osteoporosis 10.2 B2M UMOD
34 spondyloarthropathy 1 10.2 HLA-A HLA-B
35 aseptic meningitis 10.2 HLA-A HLA-B TLR4
36 bestrophinopathy 10.2 REN UMOD
37 eye carcinoma in situ 10.1 HLA-A HLA-B
38 goodpasture syndrome 10.1 HLA-A HLA-B TLR4
39 tricuspid valve insufficiency 10.1 CALCA PKDREJ
40 nasu-hakola disease 10.1 B2M HLA-A HLA-B
41 choroiditis 10.0 TLR4 UMOD
42 anterior corneal pigmentation 10.0 HLA-A HLA-B
43 acute liver failure 10.0 B2M REN
44 cystinosis 10.0 REN UMOD
45 neovascular glaucoma 9.9 TLR4 UMOD
46 glomerulonephritis 9.9
47 emphysema, congenital lobar 9.8 HLA-A HLA-B
48 malignant hypertension 9.8
49 hydronephrosis 9.8
50 nephrotic syndrome 9.8

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to Chronic Pyelonephritis

Symptoms & Phenotypes for Chronic Pyelonephritis

Drugs & Therapeutics for Chronic Pyelonephritis

Drugs for Chronic Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Bone Density Conservation Agents Phase 3
2 Diphosphonates Phase 3
3
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
4 Antidotes Phase 2
5 Anti-Infective Agents Phase 2
6 Antioxidants Phase 2
7 Antiviral Agents Phase 2
8 Expectorants Phase 2
9 N-monoacetylcystine Phase 2
10 Protective Agents Phase 2
11 Respiratory System Agents Phase 2
12
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
13 Amoxicillin-Potassium Clavulanate Combination
14 Anti-Bacterial Agents
15 beta-Lactamase Inhibitors
16 Clavulanic Acid

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Queen's University Investigation of Calcification in Chronic Kidney Disease Completed NCT00687661 Phase 3 Bisphosphonate;Placebo
2 Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children Recruiting NCT00367159 Phase 3
3 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2 Acetylcysteine;placebo acetylcysteine
4 Histology of Implantation Biopsies and Kidney Allograft Outcomes Completed NCT03155763
5 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate

Search NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

Anatomical Context for Chronic Pyelonephritis

MalaCards organs/tissues related to Chronic Pyelonephritis:

39
Kidney, Testes, Adipocyte, Bone, Prostate, Cortex, Spinal Cord

Publications for Chronic Pyelonephritis

Articles related to Chronic Pyelonephritis:

(show top 50) (show all 282)
id Title Authors Year
1
Causal Neuro-immune Relationships at Patients with Chronic Pyelonephritis and Cholecystitis. Correlations between Parameters EEG, HRV and White Blood Cell Count. ( 28730179 )
2017
2
Role of genetic mutations in development of immunological and clinical disorders in children with chronic pyelonephritis. ( 28343193 )
2017
3
Urinary cytokines as markers of latent inflammation in children with chronic pyelonephritis and anorectal malformations. ( 26936433 )
2016
4
The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis. ( 27370410 )
2016
5
AJKD Atlas of Renal Pathology: Chronic Pyelonephritis. ( 27664481 )
2016
6
Incidental primary papillary mucinous adenocarcinoma of the renal pelvis in a case of non-functioning kidney due to chronic pyelonephritis and pelvic calculus. ( 22569454 )
2012
7
Retroperitoneal-necrotizing fasciitis due to chronic pyelonephritis. ( 21063573 )
2010
8
Estimation of the kidney functional reserve as the prognosis of preeclampsia development in the pregnant woman with chronic pyelonephritis and glomerulonephritis. ( 20614512 )
2010
9
Chronic pyelonephritis presenting as a renal sinus tumor with retroperitoneal extension: a case report. ( 19918288 )
2009
10
Erythropoiesis and iron metabolism biorhythms in children with chronic pyelonephritis. ( 19240844 )
2008
11
Chronic pyelonephritis presenting as multiple tumor-like renal lesions. ( 17575382 )
2007
12
[Combined rehabilitation of patients with chronic pyelonephritis]. ( 16862887 )
2006
13
Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers. ( 15177997 )
2004
14
Recurrent eclampsia in a woman with chronic pyelonephritis. ( 11165745 )
2001
15
Massive proteinuria in a patient with chronic pyelonephritis. ( 10831663 )
2000
16
Long-term follow-up of patients presenting to adult nephrologists with chronic pyelonephritis and 'normal' renal function. ( 11110586 )
2000
17
Chronic pyelonephritis in association with neuropathic bladder. ( 10661788 )
1999
18
Effect of haemodialysis on peripheral lymphocyte carnitine levels in patients with chronic pyelonephritis. ( 10824328 )
1999
19
An unusual granulomatous form of chronic pyelonephritis mimicking tuberculosis. ( 9639129 )
1998
20
[Hormonal disorders in patients with chronic pyelonephritis with nephrosclerosis and kidney failure]. ( 9621641 )
1998
21
Urinary excretion of prostanoids in children with chronic pyelonephritis. ( 9547653 )
1997
22
[The bioregulatory therapy of patients with chronic pyelonephritis]. ( 9381626 )
1997
23
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. ( 9078596 )
1997
24
Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis. ( 9120010 )
1997
25
Role of iron and iron chelation therapy in oxygen free radical mediated tissue injury in an ascending mouse model of chronic pyelonephritis. ( 9481514 )
1997
26
[Hydrocortisol, parathyroid hormone and calcitonin in blood of patients with chronic pyelonephritis and nephrosclesosis]. ( 9471316 )
1997
27
Role of type-1 fimbriae in the pathogenesis of chronic pyelonephritis in relation to reactive oxygen species. ( 9152036 )
1997
28
Development of multiple myeloma in 2 patients with chronic pyelonephritis and long-term hemodialysis treatment. ( 8742983 )
1996
29
Clinical and histological criteria defining the diagnosis of active chronic pyelonephritis in pregnancy. ( 7774082 )
1995
30
Computed tomography evaluation of renal parenchymal volume in patients with chronic pyelonephritis and its relationship to glomerular filtration rate. ( 7735742 )
1995
31
An ascending non-obstructive model for chronic pyelonephritis in BALB/c mice. ( 7608952 )
1995
32
Mechanisms of renal damage in chronic pyelonephritis (reflux nephropathy). ( 7614849 )
1995
33
Long-term urethral catheterization increases risk of chronic pyelonephritis and renal inflammation. ( 7983294 )
1994
34
[The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. ( 7532880 )
1994
35
[Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. ( 7817590 )
1994
36
[The clinical importance of histocompatibility antigens and their combinations in the diagnosis of chronic pyelonephritis]. ( 7940364 )
1994
37
A case of nephrotic syndrome with chronic pyelonephritis. ( 8390018 )
1993
38
Renocolic fistula secondary to chronic pyelonephritis. ( 8225822 )
1993
39
Systemic amyloidosis (type AA) in end-stage renal failure patients due to chronic pyelonephritis. ( 1758552 )
1991
40
Chronic pyelonephritis: the significance of renal renin and the vascular changes in the human kidney. ( 2033493 )
1991
41
Chronic pyelonephritis masquerading as a renal neoplasm. ( 2024378 )
1991
42
Atubular glomeruli in patients with chronic pyelonephritis. ( 2332970 )
1990
43
Nephrectomy in unilateral chronic pyelonephritis. A long-term follow-up study. ( 2210973 )
1990
44
Chronic pyelonephritis: modulation of host defenses by cyclosporin A. ( 2666534 )
1989
45
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. ( 2680194 )
1989
46
P-fimbriae receptors in patients with chronic pyelonephritis. ( 2896254 )
1988
47
Potentials of ultrasonography for early diagnosis of primary chronic pyelonephritis. ( 3068178 )
1988
48
Haemorrhage due to rupture of the kidney with intraparenchymal calculi, chronic pyelonephritis and acute obstructive uropathy. A case report. ( 3187808 )
1988
49
Hypertension in chronic pyelonephritis. ( 3568676 )
1987
50
Chronic pyelonephritis in a brood mare. ( 3689265 )
1987

Variations for Chronic Pyelonephritis

Expression for Chronic Pyelonephritis

Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for Chronic Pyelonephritis

GO Terms for Chronic Pyelonephritis

Cellular components related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.67 B2M HLA-A HLA-B TLR4
2 early endosome membrane GO:0031901 9.5 B2M HLA-A HLA-B
3 phagocytic vesicle membrane GO:0030670 9.43 B2M HLA-A HLA-B
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.4 HLA-A HLA-B
5 recycling endosome membrane GO:0055038 9.33 B2M HLA-A HLA-B
6 ER to Golgi transport vesicle membrane GO:0012507 9.13 B2M HLA-A HLA-B
7 MHC class I protein complex GO:0042612 8.8 B2M HLA-A HLA-B

Biological processes related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 B2M HLA-A HLA-B TLR4
2 regulation of immune response GO:0050776 9.67 B2M HLA-A HLA-B
3 immune system process GO:0002376 9.67 B2M HLA-A HLA-B TLR4
4 antigen processing and presentation GO:0019882 9.51 HLA-A HLA-B
5 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.5 B2M HLA-A HLA-B
6 positive regulation of interleukin-8 production GO:0032757 9.48 CALCA TLR4
7 leukocyte cell-cell adhesion GO:0007159 9.46 CALCA UMOD
8 negative regulation of osteoclast differentiation GO:0045671 9.43 CALCA TLR4
9 interferon-gamma-mediated signaling pathway GO:0060333 9.43 B2M HLA-A HLA-B
10 protection from natural killer cell mediated cytotoxicity GO:0042270 9.16 HLA-A HLA-B
11 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.13 B2M HLA-A HLA-B
12 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.8 B2M HLA-A HLA-B

Molecular functions related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-A HLA-B
2 receptor binding GO:0005102 8.92 CALCA HLA-A HLA-B REN

Sources for Chronic Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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