MCID: CHR098
MIFTS: 36

Chronic Pyelonephritis malady

Category: Nephrological diseases

Aliases & Classifications for Chronic Pyelonephritis

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Aliases & Descriptions for Chronic Pyelonephritis:

Name: Chronic Pyelonephritis 11 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:1076
ICD1030 N11, N11.9
ICD9CM32 590.0
NCIt45 C123216

Summaries for Chronic Pyelonephritis

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MalaCards based summary: Chronic Pyelonephritis is related to hepatitis and hand-foot-uterus syndrome. An important gene associated with Chronic Pyelonephritis is CP (Ceruloplasmin), and among its related pathways are Downstream signaling in naive CD8+ T cells and Interferon gamma signaling. Affiliated tissues include kidney, testes and cortex.

Related Diseases for Chronic Pyelonephritis

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Diseases in the Pyelonephritis family:

chronic pyelonephritis Acute Pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis29.5HLA-A, HLA-B
2hand-foot-uterus syndrome10.8
3pyelonephritis10.7
4solid pseudopapillary carcinoma of pancreas10.2HLA-A, HLA-B
5sacral nerve root cysts10.2HLA-A, HLA-B
6myopathy, congenital nonprogressive, with moebius sequence and robin sequence10.2HLA-A, HLA-B
7epididymo-orchitis10.2HLA-A, HLA-B
8hernia of ovary and fallopian tube10.2HLA-A, HLA-B
9learning disability10.2HLA-A, HLA-B
10aortic coarctation10.2HLA-A, HLA-B
11childhood vagina botryoid rhabdomyosarcoma10.2B2M, CALCA
12colorectal cancer, hereditary nonpolyposis, type 610.2HLA-A, HLA-B
13loeffler syndrome10.2CP, LYZ
14nystagmus, congenital motor, autosomal recessive10.2HLA-A, HLA-B
15aseptic meningitis10.2HLA-A, HLA-B
16tetanus10.2CALCA, LYZ
17acanthoma10.2HLA-A, HLA-B
18prostate lymphoma10.2B2M, HLA-A
19gonococcal endophthalmia10.2HLA-A, HLA-B
20bickerstaff brainstem encephalitis10.2HLA-A, HLA-B
21mixed fibrolamellar hepatocellular carcinoma10.2HLA-A, LYZ
22anaerobic meningitis10.1HLA-A, HLA-B
23ovarian endometrioid cystadenoma10.1B2M, CALCA
24bizarre leiomyoma10.1B2M, CALCA
25choriodal dystrophy, central areolar 210.1B2M, LYZ
26hereditary lymphedema type ii10.1B2M, LYZ
27angiokeratoma10.1B2M, LYZ
28mastitis10.1HLA-A, HLA-B
29orbital osteomyelitis10.1HLA-A, HLA-B
30central nervous system lymphoma10.1CALCA, HLA-A, HLA-B
31hemorrhoid10.1B2M, LYZ
32autosomal recessive congenital methemoglobinemia10.1HLA-A, HLA-B
33idiopathic juvenile osteoporosis10.1B2M, UMOD
34goodpasture syndrome10.1CP, HLA-A, HLA-B
35folinic acid-responsive seizures10.1HLA-A, HLA-B
36parasitic helminthiasis infectious disease10.1HLA-A, HLA-B
37childhood brain meningioma10.0CALCA, CPN1
38van maldergem syndrome 29.9B2M, LYZ
39calcinosis9.9B2M, LYZ, UMOD
40glomerulonephritis9.9
41nasu-hakola disease9.9B2M, CP, HLA-A, HLA-B
42systolic heart failure9.9B2M, UMOD
43malignant hypertension9.8
44hydronephrosis9.8
45nephrotic syndrome9.8
46alternating exotropia9.8CPN1, KIAA2022, LYZ
47interstitial nephritis9.7
48nephrosclerosis9.7
49urethritis9.7
50bacteriuria9.7

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to chronic pyelonephritis

Symptoms & Phenotypes for Chronic Pyelonephritis

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Drugs & Therapeutics for Chronic Pyelonephritis

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Drugs for Chronic Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Bone Density Conservation AgentsPhase 33376
2DiphosphonatesPhase 3450
3
Etanerceptapproved, investigationalPhase 1, Phase 2403185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
4
Acetylcysteineapproved, investigationalPhase 2330616-91-112035
Synonyms:
(2R)-2-acetylamino-3-sulfanylpropanoic acid
(R)-2-acetylamino-3-mercaptopropanoic acid
(R)-mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
Fluprowit
 
L-Acetylcysteine
L-acetylcysteine
L-α-acetamido-β-mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetyl-L-(+)-cysteine
N-acetyl-L-cysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
5Peripheral Nervous System AgentsPhase 1, Phase 223689
6AnalgesicsPhase 1, Phase 211733
7Anti-Inflammatory AgentsPhase 1, Phase 210729
8Gastrointestinal AgentsPhase 1, Phase 28402
9Immunosuppressive AgentsPhase 1, Phase 213086
10Anti-Inflammatory Agents, Non-SteroidalPhase 1, Phase 24443
11Analgesics, Non-NarcoticPhase 1, Phase 26501
12Antirheumatic AgentsPhase 1, Phase 210956
13AutoantibodiesPhase 1, Phase 2130
14N-monoacetylcystinePhase 2330
15Protective AgentsPhase 27443
16ExpectorantsPhase 2404
17Respiratory System AgentsPhase 24997
18Anti-Infective AgentsPhase 222062
19AntidotesPhase 21071
20AntioxidantsPhase 23050
21Antiviral AgentsPhase 29967
22
Amoxicillinapproved, vet_approved46526787-78-033613, 2171
Synonyms:
(-)-6-(2-Amino-2-(P-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-(3.2.0)heptane-2-carboxylic acid
(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
26787-78-0
33911-69-2
34642-77-8 (mono-hydrochloride salt)
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-, D- (8CI)
6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid
6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin
6-(a-Amino-4-hydroxyphenylacetamido)penicillanic acid
6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid
6-(p-hydroxy-α-aminophenylacetamido)penicillanic acid
6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 9CI
61336-70-7 (TRIHYDRATE)
6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carbonyl
6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
71447-36-4
81030-75-3
AC-12263
AC1L1PY2
AMC
AMOXICILLIN CRYSTALLINE
AMOXICILLIN PEDIATRIC
AMPC
AUGMENTIN '125'
AUGMENTIN '200'
AUGMENTIN '250'
AUGMENTIN '400'
AUGMENTIN '500'
AUGMENTIN '875'
AUGMENTIN ES-600
AX
Actimoxi
Almodan
Ambap26787-78-0
Amix
Amoclen
Amolin
Amopen
Amopenixin
Amoram
Amox
Amox 250 Cap 250mg
Amox 500 Cap 500mg
Amox S 125 Sus 125mg/5ml
Amox S 250 Sus 250mg/5ml
Amoxi
Amoxi-Mast
Amoxi-mast
Amoxibiotic
Amoxicaps
Amoxicilina
Amoxicilina [INN-Spanish]
Amoxicillin (INN)
Amoxicillin (TN)
Amoxicillin (anhydrous)
Amoxicillin (inn)
Amoxicillin Trihydrate
Amoxicillin and clavulanate potassium
Amoxicillin anhydrous
Amoxicillin pediatric
Amoxicillin trihydrate
Amoxicillin(usan)
Amoxicilline
Amoxicilline [INN-French]
Amoxicilline [INN]
Amoxicilline [inn]
Amoxicillinum
Amoxicillinum [INN-Latin]
Amoxid
Amoxiden
Amoxil
Amoxivet
Amoxycillin
Amoxycillin Trihydrate
Amoxycillin trihydrate
Amoxycillin, BAN
Amoxymed
Amrit
Anemolin
Apo-Amoxi
Apo-Amoxi Cap 250mg
Apo-Amoxi Cap 500mg
Apo-Amoxi Pwr for Susp 125mg/5ml
Apo-Amoxi Pwr for Susp 250mg/5ml
Apo-amoxi
Apo-amoxi sugar free
Aspenil
BL-P 1410
BLP 1410
BPBio1_000499
BRD-K55044200-001-03-9
BRL 2333
BRL-2333
BSPBio_000453
 
Biomox
Bristamox
C06827
CHEBI:2676
CHEBI:53712
CHEMBL1082
CID33613
CPD000058707
Cemoxin
Clamoxyl
Clamoxyl (SKB)
D-(-)-alpha-Amino-p-hydroxybenzyl penicillin
D-(-)-alpha-Amino-p-hydroxybenzylpenicillin
D-(alpha-Amino-p-hydroxybenzyl)penicillin
D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid
D-Amoxicillin
D07452
DB01060
Delacillin
DisperMox
Dispermox
EINECS 248-003-8
Efpenix
Flemoxin
Galenamox
Gen-Amoxicillin 250mg
Gen-Amoxicillin 500mg
HMS1569G15
HSDB 3204
Hiconcil
Histocillin
Hydroxyampicillin
Ibiamox
Imacillin
LS-149721
Lamoxy
Larotid
MLS000028632
MLS002222248
Metafarma capsules
Metifarma capsules
MolPort-003-981-182
MolPort-005-933-687
Moxacin
Moxal
Moxatag
NCGC00179554-01
NSC 277174
NSC277174
Novamoxin Cap 250mg
Novamoxin Cap 500mg
Novamoxin Sus 125mg/5ml
Novamoxin Sus 250mg/5ml
Nu-Amoxi Cap 250mg
Nu-Amoxi Cap 500mg
Nu-Amoxi Sus 125/5ml
Nu-Amoxi Sus 250mg/5ml
Ospamox
P-Hydroxyampicillin
PHL-amoxicillin
PMS-amoxicillin
Pamoxicillin
Piramox
Polymox
Prestwick0_000357
Prestwick1_000357
Prestwick2_000357
Prestwick3_000357
Prestwick_713
Prevpac
Pro Amox Pwr for Oral Susp 125mg/5ml
Pro Amox-250 Cap 250mg
Pro Amox-500 Cap 500mg
Pro-Amox-250 Orl Sus 250mg/5ml
R-Hydroxyampicillin
Rimoxallin
Ro 10-8756
Robamox
SAM002264592
SMR000058707
SPBio_002374
Sauracillin
Sawamox PM
Sumox
Tolodina
Trimox
Unicillin
Utimox
Vetramox
Wymox
Zimox
alpha-Amino-p-hydroxybenzylpenicillin
amoxicillanyl
amoxicillin
p-Hydroxyampicillin
α-amino-p-hydroxybenzylpenicillin
23Clavulanic Acid170
24beta-Lactamase Inhibitors294
25Anti-Bacterial Agents11226
26Amoxicillin-Potassium Clavulanate Combination137

Interventional clinical trials:

idNameStatusNCT IDPhase
1Queen's University Investigation of Calcification in Chronic Kidney DiseaseCompletedNCT00687661Phase 3
2Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in ChildrenRecruitingNCT00367159Phase 3
3ASIS for Enbrel in Plaque PsoriasisUnknown statusNCT02112097Phase 1, Phase 2
4Effect of Acetylcysteine in Pediatric Acute Pyelonephritis.CompletedNCT02080182Phase 2
5Histology of Implantation Biopsies and Kidney Allograft OutcomesCompletedNCT03155763
6Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)CompletedNCT01406275

Search NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

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Anatomical Context for Chronic Pyelonephritis

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MalaCards organs/tissues related to Chronic Pyelonephritis:

36
Kidney, Testes, Cortex, Prostate, Liver, Spinal cord, Ovary

Publications for Chronic Pyelonephritis

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Articles related to Chronic Pyelonephritis:

(show top 50)    (show all 280)
idTitleAuthorsYear
1
AJKD Atlas of Renal Pathology: Chronic Pyelonephritis. (27664481)
2016
2
The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis. (27370410)
2016
3
Urinary cytokines as markers of latent inflammation in children with chronic pyelonephritis and anorectal malformations. (26936433)
2016
4
Incidental primary papillary mucinous adenocarcinoma of the renal pelvis in a case of non-functioning kidney due to chronic pyelonephritis and pelvic calculus. (22569454)
2012
5
Estimation of the kidney functional reserve as the prognosis of preeclampsia development in the pregnant woman with chronic pyelonephritis and glomerulonephritis. (20614512)
2010
6
Retroperitoneal-necrotizing fasciitis due to chronic pyelonephritis. (21063573)
2010
7
Chronic pyelonephritis presenting as a renal sinus tumor with retroperitoneal extension: a case report. (19918288)
2009
8
Erythropoiesis and iron metabolism biorhythms in children with chronic pyelonephritis. (19240844)
2008
9
Chronic pyelonephritis presenting as multiple tumor-like renal lesions. (17575382)
2007
10
Combined rehabilitation of patients with chronic pyelonephritis]. (16862887)
2006
11
Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers. (15177997)
2004
12
Recurrent eclampsia in a woman with chronic pyelonephritis. (11165745)
2001
13
Long-term follow-up of patients presenting to adult nephrologists with chronic pyelonephritis and 'normal' renal function. (11110586)
2000
14
Massive proteinuria in a patient with chronic pyelonephritis. (10831663)
2000
15
Effect of haemodialysis on peripheral lymphocyte carnitine levels in patients with chronic pyelonephritis. (10824328)
1999
16
Chronic pyelonephritis in association with neuropathic bladder. (10661788)
1999
17
Hormonal disorders in patients with chronic pyelonephritis with nephrosclerosis and kidney failure]. (9621641)
1998
18
An unusual granulomatous form of chronic pyelonephritis mimicking tuberculosis. (9639129)
1998
19
Hydrocortisol, parathyroid hormone and calcitonin in blood of patients with chronic pyelonephritis and nephrosclesosis]. (9471316)
1997
20
Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis. (9120010)
1997
21
The bioregulatory therapy of patients with chronic pyelonephritis]. (9381626)
1997
22
Urinary excretion of prostanoids in children with chronic pyelonephritis. (9547653)
1997
23
Role of type-1 fimbriae in the pathogenesis of chronic pyelonephritis in relation to reactive oxygen species. (9152036)
1997
24
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
25
Role of iron and iron chelation therapy in oxygen free radical mediated tissue injury in an ascending mouse model of chronic pyelonephritis. (9481514)
1997
26
Development of multiple myeloma in 2 patients with chronic pyelonephritis and long-term hemodialysis treatment. (8742983)
1996
27
An ascending non-obstructive model for chronic pyelonephritis in BALB/c mice. (7608952)
1995
28
Mechanisms of renal damage in chronic pyelonephritis (reflux nephropathy). (7614849)
1995
29
Clinical and histological criteria defining the diagnosis of active chronic pyelonephritis in pregnancy. (7774082)
1995
30
Computed tomography evaluation of renal parenchymal volume in patients with chronic pyelonephritis and its relationship to glomerular filtration rate. (7735742)
1995
31
The clinical importance of histocompatibility antigens and their combinations in the diagnosis of chronic pyelonephritis]. (7940364)
1994
32
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
33
The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. (7532880)
1994
34
Long-term urethral catheterization increases risk of chronic pyelonephritis and renal inflammation. (7983294)
1994
35
A case of nephrotic syndrome with chronic pyelonephritis. (8390018)
1993
36
Renocolic fistula secondary to chronic pyelonephritis. (8225822)
1993
37
Chronic pyelonephritis: the significance of renal renin and the vascular changes in the human kidney. (2033493)
1991
38
Systemic amyloidosis (type AA) in end-stage renal failure patients due to chronic pyelonephritis. (1758552)
1991
39
Chronic pyelonephritis masquerading as a renal neoplasm. (2024378)
1991
40
Atubular glomeruli in patients with chronic pyelonephritis. (2332970)
1990
41
Nephrectomy in unilateral chronic pyelonephritis. A long-term follow-up study. (2210973)
1990
42
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. (2680194)
1989
43
Chronic pyelonephritis: modulation of host defenses by cyclosporin A. (2666534)
1989
44
Haemorrhage due to rupture of the kidney with intraparenchymal calculi, chronic pyelonephritis and acute obstructive uropathy. A case report. (3187808)
1988
45
P-fimbriae receptors in patients with chronic pyelonephritis. (2896254)
1988
46
Potentials of ultrasonography for early diagnosis of primary chronic pyelonephritis. (3068178)
1988
47
Hypertension in chronic pyelonephritis. (3568676)
1987
48
Chronic pyelonephritis in a brood mare. (3689265)
1987
49
Virulence properties of Escherichia coli strains in patients with chronic pyelonephritis. (2874114)
1986
50
The phosphatidylcholine metabolism in the renal tissue during experimental acute and chronic pyelonephritis in the rabbit. (3792487)
1986

Variations for Chronic Pyelonephritis

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Expression for genes affiliated with Chronic Pyelonephritis

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Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for genes affiliated with Chronic Pyelonephritis

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GO Terms for genes affiliated with Chronic Pyelonephritis

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Cellular components related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.4HLA-A, HLA-B
2early endosome membraneGO:003190110.2B2M, HLA-A, HLA-B
3ER to Golgi transport vesicle membraneGO:001250710.2B2M, HLA-A, HLA-B
4specific granule lumenGO:003558010.0B2M, LYZ
5MHC class I protein complexGO:00426129.9B2M, HLA-A, HLA-B
6phagocytic vesicle membraneGO:00306709.9B2M, HLA-A, HLA-B
7recycling endosome membraneGO:00550389.9B2M, HLA-A, HLA-B
8tertiary granule lumenGO:19047249.5B2M, LYZ
9extracellular exosomeGO:00700628.8B2M, CP, HLA-A, HLA-B, LYZ, UMOD
10extracellular spaceGO:00056158.6B2M, CALCA, CP, CPN1, LYZ
11extracellular regionGO:00055768.2B2M, CALCA, CP, CPN1, LYZ, UMOD

Biological processes related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentationGO:001988210.4HLA-A, HLA-B
2protection from natural killer cell mediated cytotoxicityGO:004227010.4HLA-A, HLA-B
3leukocyte cell-cell adhesionGO:000715910.1CALCA, UMOD
4retina homeostasisGO:000189510.0B2M, LYZ
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:000247910.0B2M, HLA-A, HLA-B
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:000248010.0B2M, HLA-A, HLA-B
7antigen processing and presentation of peptide antigen via MHC class IGO:000247410.0B2M, HLA-A, HLA-B
8interferon-gamma-mediated signaling pathwayGO:006033310.0B2M, HLA-A, HLA-B
9regulation of immune responseGO:00507769.9B2M, HLA-A, HLA-B
10type I interferon signaling pathwayGO:00603379.8HLA-A, HLA-B
11cellular protein metabolic processGO:00442679.4B2M, CALCA, CP, LYZ

Molecular functions related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.8HLA-A, HLA-B

Sources for Chronic Pyelonephritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet