MCID: CHR098
MIFTS: 40

Chronic Pyelonephritis malady

Summaries for Chronic Pyelonephritis

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MalaCards based summary: Chronic Pyelonephritis is related to pyelonephritis and bacteriuria. An important gene associated with Chronic Pyelonephritis is NAGLU (N-acetylglucosaminidase, alpha), and among its related pathways are TCR signaling in naive CD4+ T cells and Downstream signaling in naive CD8+ T cells. The compounds 99mtc-dmsa and amikacin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and cortex, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Classifications for Chronic Pyelonephritis

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Chronic Pyelonephritis, Aliases & Descriptions:

Name: Chronic Pyelonephritis 9 43 60


External Ids:

Disease Ontology9 DOID:1076
ICD9CM27 590.0

Related Diseases for Chronic Pyelonephritis

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Diseases in the Pyelonephritis family:

Acute Pyelonephritis chronic pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis31.9B2M, NAGLU, UMOD, CD79A
2bacteriuria31.1UMOD
3prostatitis30.9CD79A
4vesicoureteral reflux30.8NAGLU, UMOD
5nephritis30.7CD79A, ALB, B2M
6cystitis30.6NAGLU, UMOD
7nephrotic syndrome30.4CD79A, ALB, NAGLU, B2M
8uremia30.3ALB, B2M
9glomerulonephritis30.3CD79A, ALB, UMOD, NAGLU, B2M
10proteinuria30.2B2M, NAGLU, UMOD, ALB, CD79A
11amyloidosis30.1B2M, ALB, CD79A
12hepatitis29.9ALB, HLA-A
13myeloma29.7B2M, NAGLU, UMOD, ALB, CD79A
14tuberculosis29.4HLA-A, CP, ALB, CD79A
15chronic kidney failure29.2HLA-A, B2M, NAGLU, UMOD, ALB, CD79A
16osteitis fibrosa10.5B2M
17protein-losing enteropathy10.4ALB
18hyperthyroxinemia10.4ALB
19hepatorenal syndrome10.4ALB
20acute poststreptococcal glomerulonephritis10.4CD79A
21gastroenteritis10.4CD79A
22hemosiderosis10.4CP
23acute kidney tubular necrosis10.4NAGLU, UMOD
24urinary system disease10.4B2M, NAGLU
25nephrolithiasis10.4NAGLU, UMOD
26nephrocalcinosis10.3NAGLU, UMOD
27hydronephrosis10.3
28malignant hypertension10.3
29pseudohypoparathyroidism10.3NAGLU, CALCA
30paget disease of bone10.3B2M, CALCA
31hypoparathyroidism10.3NAGLU, CALCA
32hypophosphatemia10.3B2M, CALCA
33macroglobulinemia10.3B2M, CD79A
34plasmacytoma10.2B2M, CD79A
35urinary tract obstruction10.2B2M, NAGLU, UMOD
36acquired immunodeficiency syndrome10.2ALB, B2M
37hemochromatosis10.2CP, B2M
38peripheral vascular disease10.2CD79A, ALB
39thyroiditis10.2CALCA, CD79A
40membranous glomerulonephritis, antenatal10.2ALB, CD79A
41metabolic acidosis10.2B2M, ALB
42urethritis10.2
43nephrosclerosis10.2
44interstitial nephritis10.2
45peritonitis10.2B2M, ALB
46hyperparathyroidism10.2ALB, CALCA
47acute liver failure10.2CP, ALB
48rhinitis10.2CD79A, ALB
49secondary syphilis10.1B2M, CALCA
50non-suppurative otitis media10.1NAGLU, CP

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to chronic pyelonephritis

Symptoms for Chronic Pyelonephritis

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Drugs & Therapeutics for Chronic Pyelonephritis

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Drug clinical trials:

Search ClinicalTrials for Chronic Pyelonephritis

Search NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

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Anatomical Context for Chronic Pyelonephritis

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MalaCards organs/tissues related to Chronic Pyelonephritis:

31
Kidney, Testes, Cortex, Prostate, Spinal cord, Liver, Ovary

Animal Models for Chronic Pyelonephritis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Pyelonephritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5CD79A, UMOD, NAGLU, CP, B2M
2MP:00053708.1B2M, CP, NAGLU, ALB
3MP:00053678.1CD79A, ALB, CALCA, UMOD, NAGLU
4MP:00053767.4B2M, CP, UMOD, CALCA, ALB, CD79A

Publications for Chronic Pyelonephritis

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Articles related to Chronic Pyelonephritis:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
Chronic pyelonephritis presenting as multiple tumor-like renal lesions. (17575382)
2007
2
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. (9078596)
1997
3
Computed tomography evaluation of renal parenchymal volume in patients with chronic pyelonephritis and its relationship to glomerular filtration rate. (7735742)
1995
4
Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. (7817590)
1994
5
The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. (7532880)
1994
6
Atubular glomeruli in patients with chronic pyelonephritis. (2332970)
1990
7
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. (2680194)
1989
8
P-fimbriae receptors in patients with chronic pyelonephritis. (2896254)
1988
9
Auto-antibody to kidney tubular cells during retrograde chronic pyelonephritis in rats. (3885065)
1985
10
Role of Tamm-Horsfall protein in the pathogenesis of reflux nephropathy and chronic pyelonephritis. (3912177)
1985
11
Immunopathology of the glomerular changes in chronic pyelonephritis. (386707)
1979
12
Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. (633491)
1978
13
Long-term study of humoral immune response in patients with chronic pyelonephritis. (788977)
1976
14
Diagnostic value of ceruloplasmin, haptoglobin and sialic acid in chronic pyelonephritis. (965209)
1976
15
Hypertension in children with chronic pyelonephritis. (1059804)
1975
16
The occurrence of mycoplasmas in the urinary tract of patients with chronic pyelonephritis. (1130197)
1975
17
Letter: Urinary reflux and chronic pyelonephritis. (46073)
1975
18
The incidence of chronic pyelonephritis in schistosomal hepatic fibrosis utilising the prednisolone provocation test. (4726339)
1973
19
Improved treatment of chronic pyelonephritis with nitrofurantoin in combination with deglycyrrhizinated liquorice. (4556768)
1972
20
What is chronic pyelonephritis? (5551266)
1971
21
Chronic pyelonephritis and renal medullary necrosis. (5155285)
1971
22
Medical management of chronic pyelonephritis: acute and chronic. (5428975)
1970
23
Effect of water diuresis on chronic pyelonephritis. (5659542)
1968
24
Chronic pyelonephritis: relative incidence in transplant recipients. (5330923)
1966
25
Asymmetry of renal function with special references to chronic pyelonephritis. (5220569)
1966
26
UROLOGICAL SURVEY OF CHRONIC PYELONEPHRITIS AND RECURRENT URINARY INFECTION WITHOUT OBSTRUCTION. (14269350)
1965
27
A NEW ANTIMICROBIAL AGENT, NEGGRAM, USED IN CHRONIC PYELONEPHRITIS. (14340960)
1965
28
PATHOGENESIS OF CHRONIC PYELONEPHRITIS. II. EFFECT OF REPETITIVE INFECTION. (14223578)
1964
29
ROLE OF CHRONIC PYELONEPHRITIS IN THE PRODUCTION OF EXPERIMENTAL HYDRONEPHROSIS. (14226454)
1964
30
POTASSIUM DEPLETION AND CHRONIC PYELONEPHRITIS. (14124095)
1964
31
CHRONIC PYELONEPHRITIS AND THE ANTIBIOTICS. (14062883)
1963
32
Long-term treatment of chronic pyelonephritis in children. (13955227)
1963
33
Presentation and diagnosis of chronic pyelonephritis. (13928854)
1963
34
Problems of chronic pyelonephritis. (13974947)
1963
35
Multiple-antibiotic-resistant enteric bacilli in chronic pyelonephritis. A one-year study in the Philippine General Hospital. (14465338)
1962
36
The finding of chronic pyelonephritis in males and females at autopsy. (13756618)
1960
37
Hematogenous pyelonephritis in rats. IV. Relationship of bacterial species to the pathogenesis and sequelae of chronic pyelonephritis. (13664797)
1959
38
Chronic pyelonephritis lenta and the "malignant phase of hypertension". (14441666)
1959
39
Chronic pyelonephritis. (13668710)
1959
40
Unilateral renal function in chronic pyelonephritis and renal papillary necrosis; a study on the function of the separate kidneys with the aid of selective renal clearance and renal vein catheterization. (13558903)
1958
41
The pathogenesis of chronic pyelonephritis. (13610072)
1958
42
Chronic pyelonephritis with xanthogranulomatous change; report of 3 cases. (13248828)
1955
43
Chronic pyelonephritis. (13131022)
1954
44
Polymyxin B in chronic pyelonephritis: observations on the safety of the drug and on its influence on the renal infection. (13030476)
1953
45
WEEKLY clinicopathological exercises; ectopic left kidney (in pelvis) with chronic pyelonephritis; congenital absence of right kidney, ovary & salpinx. (14890819)
1952
46
Clinico-pathological conference: hypoplasia of the kidneys secondary to chronic pyelonephritis; acute bronchitis; myocardial hypertrophy; fatty metamorphosis of the liver; rickets. (14870327)
1951
47
Chronic pyelonephritis simulating Addison's disease. (15413207)
1950
48
Chronic pyelonephritis and hypertension. (14795114)
1950
49
Pregnancy following lumbodorsal splanchnicectomy for essential and malignant hypertension and hypertension associated with chronic pyelonephritis. (20241256)
1947
50
Duodenal obstruction caused by chronic pyelonephritis and hydronephrosis. (21014787)
1946

Variations for Chronic Pyelonephritis

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Expression for genes affiliated with Chronic Pyelonephritis

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Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for genes affiliated with Chronic Pyelonephritis

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Compounds for genes affiliated with Chronic Pyelonephritis

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Compounds related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
199mtc-dmsa4310.0NAGLU, B2M
2amikacin4310.0NAGLU, B2M
3fosfomycin439.9NAGLU, B2M
4tobramycin439.9NAGLU, B2M
5dmsa439.8B2M, NAGLU, CALCA
6aluminium43 1210.7B2M, NAGLU
7pmma439.6CD79A, CALCA, B2M
8polyether sulfone439.5B2M, ALB
9neopterin439.5CD79A, NAGLU, B2M
10mesna439.5NAGLU, B2M
1151-cr-edta439.5ALB, B2M
12iopentol439.4NAGLU, B2M, ALB
13p-aminohippuric acid439.4NAGLU, B2M, ALB
14inulin439.4ALB, NAGLU, B2M
15iohexol439.4ALB, NAGLU, B2M
16fluoride439.3NAGLU, B2M, CALCA, CD79A
17sevoflurane49 43 1211.3B2M, NAGLU, ALB
18galactose439.3UMOD, CD79A, B2M
19isoflurane49 43 1211.3NAGLU, CALCA, ALB
20vitamin-e439.3CP, NAGLU, B2M
21gamma globulin439.2ALB, CD79A, B2M
22sialic acid439.2CP, NAGLU, UMOD, CD79A
23furosemide43 59 28 49 24 1214.2NAGLU, CALCA, ALB
2425-hydroxyvitamin d439.2ALB, CALCA, B2M
25cellulose acetate439.2ALB, B2M, CD79A
26urea43 24 1211.0B2M, NAGLU, UMOD, ALB
27phosphorus439.0ALB, B2M, NAGLU, CALCA
28carbamazepine43 49 1211.0CD79A, NAGLU, HLA-A, CP
29phenytoin43 49 28 1211.9CD79A, ALB, CP
30hyaluronic acid43 249.9NAGLU, ALB, CD79A, B2M
31captopril43 59 49 28 1212.8B2M, CALCA, ALB, CD79A
32mannitol43 129.8NAGLU, ALB, CP, B2M
33vitamin a43 24 1210.8ALB, B2M, CP, NAGLU
34vitamin b12438.7CD79A, ALB, B2M, CP
35cyclosporin a43 28 5910.7CD79A, CALCA, NAGLU, B2M, HLA-A
36folate438.7CD79A, B2M, ALB, CP
37tacrolimus43 49 1210.6HLA-A, CD79A, ALB, NAGLU
38uric acid43 249.5B2M, CP, NAGLU, UMOD, ALB
39citrate438.5ALB, CD79A, UMOD, NAGLU, CP
40heparin43 28 24 1211.4CD79A, NAGLU, UMOD, ALB, CP
41thyroxine43 249.3B2M, CP, CALCA, ALB, CD79A
42indomethacin43 28 59 1211.3CD79A, ALB, CALCA, CP, B2M
43cholesterol43 28 24 1211.2CP, B2M, ALB, LPXN, NAGLU
44testosterone43 59 24 1211.2CD79A, ALB, CALCA, B2M, CP
45glucose438.2ALB, UMOD, LPXN, NAGLU, B2M
46vitamin d438.0B2M, CP, CALCA, ALB, CD79A, NAGLU
47cysteine438.0B2M, CP, NAGLU, UMOD, ALB, CD79A
48lactate438.0NAGLU, CALCA, B2M, ALB, CD79A, CP
49alanine437.8CP, CD79A, ALB, NAGLU, B2M, HLA-A
50creatinine437.7B2M, ALB, CALCA, UMOD, NAGLU, CP

GO Terms for genes affiliated with Chronic Pyelonephritis

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Cellular components related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:00306709.5B2M, HLA-A
2MHC class I protein complexGO:00426129.4B2M, HLA-A
3ER to Golgi transport vesicle membraneGO:00125079.2B2M, HLA-A
4extracellular spaceGO:00056158.0B2M, CP, UMOD, CALCA, ALB
5extracellular vesicular exosomeGO:00700627.5ALB, UMOD, NAGLU, CP, B2M, HLA-A

Biological processes related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00024809.6B2M, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:00019169.5B2M, HLA-A
3regulation of defense response to virus by virusGO:00506909.5B2M, HLA-A
4interferon-gamma-mediated signaling pathwayGO:00603339.5B2M, HLA-A
5response to organic substanceGO:00100339.2UMOD, ALB
6retina homeostasisGO:00018959.0ALB, B2M

Molecular functions related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.1ALB, CP
2chaperone bindingGO:00510878.8ALB, CP

Products for genes affiliated with Chronic Pyelonephritis

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Sources for Chronic Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet