MCID: CHR098
MIFTS: 36

Chronic Pyelonephritis malady

Categories: Nephrological diseases

Aliases & Classifications for Chronic Pyelonephritis

Aliases & Descriptions for Chronic Pyelonephritis:

Name: Chronic Pyelonephritis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1076
ICD10 33 N11 N11.9
ICD9CM 35 590.0
NCIt 47 C123216
UMLS 69 C0085697

Summaries for Chronic Pyelonephritis

MalaCards based summary : Chronic Pyelonephritis is related to hepatitis and hand-foot-uterus syndrome. An important gene associated with Chronic Pyelonephritis is CP (Ceruloplasmin), and among its related pathways/superpathways are Interferon gamma signaling and Antigen processing-Cross presentation. The drugs Diphosphonates and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate.

Related Diseases for Chronic Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.5 HLA-A HLA-B
2 hand-foot-uterus syndrome 10.8
3 pyelonephritis 10.7
4 solid pseudopapillary carcinoma of pancreas 10.2 HLA-A HLA-B
5 sacral nerve root cysts 10.2 HLA-A HLA-B
6 myopathy, congenital nonprogressive, with moebius sequence and robin sequence 10.2 HLA-A HLA-B
7 epididymo-orchitis 10.2 HLA-A HLA-B
8 hernia of ovary and fallopian tube 10.2 HLA-A HLA-B
9 learning disability 10.2 HLA-A HLA-B
10 aortic coarctation 10.2 HLA-A HLA-B
11 childhood vagina botryoid rhabdomyosarcoma 10.2 B2M CALCA
12 colorectal cancer, hereditary nonpolyposis, type 6 10.2 HLA-A HLA-B
13 loeffler syndrome 10.2 CP LYZ
14 nystagmus, congenital motor, autosomal recessive 10.2 HLA-A HLA-B
15 aseptic meningitis 10.2 HLA-A HLA-B
16 tetanus 10.2 CALCA LYZ
17 acanthoma 10.2 HLA-A HLA-B
18 prostate lymphoma 10.2 B2M HLA-A
19 gonococcal endophthalmia 10.2 HLA-A HLA-B
20 bickerstaff brainstem encephalitis 10.2 HLA-A HLA-B
21 mixed fibrolamellar hepatocellular carcinoma 10.2 HLA-A LYZ
22 anaerobic meningitis 10.1 HLA-A HLA-B
23 ovarian endometrioid cystadenoma 10.1 B2M CALCA
24 bizarre leiomyoma 10.1 B2M CALCA
25 choriodal dystrophy, central areolar 2 10.1 B2M LYZ
26 hereditary lymphedema type ii 10.1 B2M LYZ
27 angiokeratoma 10.1 B2M LYZ
28 mastitis 10.1 HLA-A HLA-B
29 orbital osteomyelitis 10.1 HLA-A HLA-B
30 central nervous system lymphoma 10.1 CALCA HLA-A HLA-B
31 hemorrhoid 10.1 B2M LYZ
32 autosomal recessive congenital methemoglobinemia 10.1 HLA-A HLA-B
33 idiopathic juvenile osteoporosis 10.1 B2M UMOD
34 goodpasture syndrome 10.1 CP HLA-A HLA-B
35 folinic acid-responsive seizures 10.1 HLA-A HLA-B
36 parasitic helminthiasis infectious disease 10.1 HLA-A HLA-B
37 childhood brain meningioma 10.0 CALCA CPN1
38 van maldergem syndrome 2 9.9 B2M LYZ
39 calcinosis 9.9 B2M LYZ UMOD
40 glomerulonephritis 9.9
41 nasu-hakola disease 9.9 B2M CP HLA-A HLA-B
42 systolic heart failure 9.9 B2M UMOD
43 nephrotic syndrome 9.8
44 malignant hypertension 9.8
45 hydronephrosis 9.8
46 alternating exotropia 9.8 CPN1 KIAA2022 LYZ
47 nephrosclerosis 9.7
48 urethritis 9.7
49 bacteriuria 9.7
50 prostatitis 9.7

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to Chronic Pyelonephritis

Symptoms & Phenotypes for Chronic Pyelonephritis

Drugs & Therapeutics for Chronic Pyelonephritis

Drugs for Chronic Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Diphosphonates Phase 3
2 Bone Density Conservation Agents Phase 3
3
Etanercept Approved, Investigational Phase 1, Phase 2 185243-69-0
4
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
5 Analgesics Phase 1, Phase 2
6 Gastrointestinal Agents Phase 1, Phase 2
7 Analgesics, Non-Narcotic Phase 1, Phase 2
8 Peripheral Nervous System Agents Phase 1, Phase 2
9 Immunosuppressive Agents Phase 1, Phase 2
10 Anti-Inflammatory Agents Phase 1, Phase 2
11 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
12 Antirheumatic Agents Phase 1, Phase 2
13 Autoantibodies Phase 1, Phase 2
14 N-monoacetylcystine Phase 2
15 Expectorants Phase 2
16 Anti-Infective Agents Phase 2
17 Protective Agents Phase 2
18 Antidotes Phase 2
19 Respiratory System Agents Phase 2
20 Antiviral Agents Phase 2
21 Antioxidants Phase 2
22
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
23 Clavulanic Acid
24 Amoxicillin-Potassium Clavulanate Combination
25 Anti-Bacterial Agents
26 beta-Lactamase Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase
1 Queen's University Investigation of Calcification in Chronic Kidney Disease Completed NCT00687661 Phase 3
2 Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children Recruiting NCT00367159 Phase 3
3 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2
4 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2
5 Histology of Implantation Biopsies and Kidney Allograft Outcomes Completed NCT03155763
6 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275

Search NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

Anatomical Context for Chronic Pyelonephritis

MalaCards organs/tissues related to Chronic Pyelonephritis:

39
Kidney, Testes, Prostate, Cortex, Liver, Ovary, Spinal Cord

Publications for Chronic Pyelonephritis

Articles related to Chronic Pyelonephritis:

(show top 50) (show all 280)
id Title Authors Year
1
AJKD Atlas of Renal Pathology: Chronic Pyelonephritis. ( 27664481 )
2016
2
The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis. ( 27370410 )
2016
3
Urinary cytokines as markers of latent inflammation in children with chronic pyelonephritis and anorectal malformations. ( 26936433 )
2016
4
Incidental primary papillary mucinous adenocarcinoma of the renal pelvis in a case of non-functioning kidney due to chronic pyelonephritis and pelvic calculus. ( 22569454 )
2012
5
Estimation of the kidney functional reserve as the prognosis of preeclampsia development in the pregnant woman with chronic pyelonephritis and glomerulonephritis. ( 20614512 )
2010
6
Retroperitoneal-necrotizing fasciitis due to chronic pyelonephritis. ( 21063573 )
2010
7
Chronic pyelonephritis presenting as a renal sinus tumor with retroperitoneal extension: a case report. ( 19918288 )
2009
8
Erythropoiesis and iron metabolism biorhythms in children with chronic pyelonephritis. ( 19240844 )
2008
9
Chronic pyelonephritis presenting as multiple tumor-like renal lesions. ( 17575382 )
2007
10
[Combined rehabilitation of patients with chronic pyelonephritis]. ( 16862887 )
2006
11
Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers. ( 15177997 )
2004
12
Recurrent eclampsia in a woman with chronic pyelonephritis. ( 11165745 )
2001
13
Long-term follow-up of patients presenting to adult nephrologists with chronic pyelonephritis and 'normal' renal function. ( 11110586 )
2000
14
Massive proteinuria in a patient with chronic pyelonephritis. ( 10831663 )
2000
15
Effect of haemodialysis on peripheral lymphocyte carnitine levels in patients with chronic pyelonephritis. ( 10824328 )
1999
16
Chronic pyelonephritis in association with neuropathic bladder. ( 10661788 )
1999
17
[Hormonal disorders in patients with chronic pyelonephritis with nephrosclerosis and kidney failure]. ( 9621641 )
1998
18
An unusual granulomatous form of chronic pyelonephritis mimicking tuberculosis. ( 9639129 )
1998
19
[Hydrocortisol, parathyroid hormone and calcitonin in blood of patients with chronic pyelonephritis and nephrosclesosis]. ( 9471316 )
1997
20
Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis. ( 9120010 )
1997
21
[The bioregulatory therapy of patients with chronic pyelonephritis]. ( 9381626 )
1997
22
Urinary excretion of prostanoids in children with chronic pyelonephritis. ( 9547653 )
1997
23
Role of type-1 fimbriae in the pathogenesis of chronic pyelonephritis in relation to reactive oxygen species. ( 9152036 )
1997
24
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. ( 9078596 )
1997
25
Role of iron and iron chelation therapy in oxygen free radical mediated tissue injury in an ascending mouse model of chronic pyelonephritis. ( 9481514 )
1997
26
Development of multiple myeloma in 2 patients with chronic pyelonephritis and long-term hemodialysis treatment. ( 8742983 )
1996
27
An ascending non-obstructive model for chronic pyelonephritis in BALB/c mice. ( 7608952 )
1995
28
Mechanisms of renal damage in chronic pyelonephritis (reflux nephropathy). ( 7614849 )
1995
29
Clinical and histological criteria defining the diagnosis of active chronic pyelonephritis in pregnancy. ( 7774082 )
1995
30
Computed tomography evaluation of renal parenchymal volume in patients with chronic pyelonephritis and its relationship to glomerular filtration rate. ( 7735742 )
1995
31
[The clinical importance of histocompatibility antigens and their combinations in the diagnosis of chronic pyelonephritis]. ( 7940364 )
1994
32
[Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. ( 7817590 )
1994
33
[The correction of the immune disorders in patients with chronic pyelonephritis and chronic kidney failure]. ( 7532880 )
1994
34
Long-term urethral catheterization increases risk of chronic pyelonephritis and renal inflammation. ( 7983294 )
1994
35
A case of nephrotic syndrome with chronic pyelonephritis. ( 8390018 )
1993
36
Renocolic fistula secondary to chronic pyelonephritis. ( 8225822 )
1993
37
Chronic pyelonephritis: the significance of renal renin and the vascular changes in the human kidney. ( 2033493 )
1991
38
Systemic amyloidosis (type AA) in end-stage renal failure patients due to chronic pyelonephritis. ( 1758552 )
1991
39
Chronic pyelonephritis masquerading as a renal neoplasm. ( 2024378 )
1991
40
Atubular glomeruli in patients with chronic pyelonephritis. ( 2332970 )
1990
41
Nephrectomy in unilateral chronic pyelonephritis. A long-term follow-up study. ( 2210973 )
1990
42
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. ( 2680194 )
1989
43
Chronic pyelonephritis: modulation of host defenses by cyclosporin A. ( 2666534 )
1989
44
Haemorrhage due to rupture of the kidney with intraparenchymal calculi, chronic pyelonephritis and acute obstructive uropathy. A case report. ( 3187808 )
1988
45
P-fimbriae receptors in patients with chronic pyelonephritis. ( 2896254 )
1988
46
Potentials of ultrasonography for early diagnosis of primary chronic pyelonephritis. ( 3068178 )
1988
47
Hypertension in chronic pyelonephritis. ( 3568676 )
1987
48
Chronic pyelonephritis in a brood mare. ( 3689265 )
1987
49
Virulence properties of Escherichia coli strains in patients with chronic pyelonephritis. ( 2874114 )
1986
50
The phosphatidylcholine metabolism in the renal tissue during experimental acute and chronic pyelonephritis in the rabbit. ( 3792487 )
1986

Variations for Chronic Pyelonephritis

Expression for Chronic Pyelonephritis

Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for Chronic Pyelonephritis

GO Terms for Chronic Pyelonephritis

Cellular components related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.93 B2M CP HLA-A HLA-B LYZ UMOD
2 extracellular region GO:0005576 9.88 B2M CALCA CP CPN1 LYZ UMOD
3 extracellular space GO:0005615 9.83 B2M CALCA CP CPN1 LYZ
4 early endosome membrane GO:0031901 9.5 B2M HLA-A HLA-B
5 specific granule lumen GO:0035580 9.49 B2M LYZ
6 tertiary granule lumen GO:1904724 9.48 B2M LYZ
7 phagocytic vesicle membrane GO:0030670 9.43 B2M HLA-A HLA-B
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.37 HLA-A HLA-B
9 recycling endosome membrane GO:0055038 9.33 B2M HLA-A HLA-B
10 ER to Golgi transport vesicle membrane GO:0012507 9.13 B2M HLA-A HLA-B
11 MHC class I protein complex GO:0042612 8.8 B2M HLA-A HLA-B

Biological processes related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.61 B2M HLA-A HLA-B
2 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.54 B2M HLA-A HLA-B
3 interferon-gamma-mediated signaling pathway GO:0060333 9.5 B2M HLA-A HLA-B
4 type I interferon signaling pathway GO:0060337 9.49 HLA-A HLA-B
5 antigen processing and presentation GO:0019882 9.48 HLA-A HLA-B
6 retina homeostasis GO:0001895 9.46 B2M LYZ
7 cellular protein metabolic process GO:0044267 9.46 B2M CALCA CP LYZ
8 leukocyte cell-cell adhesion GO:0007159 9.4 CALCA UMOD
9 protection from natural killer cell mediated cytotoxicity GO:0042270 9.26 HLA-A HLA-B
10 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.13 B2M HLA-A HLA-B
11 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.8 B2M HLA-A HLA-B

Molecular functions related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-A HLA-B

Sources for Chronic Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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