CMO
MCID: CHR288
MIFTS: 49

Chronic Recurrent Multifocal Osteomyelitis (CMO) malady

Rare diseases, Bone diseases, Skin diseases categories

Summaries for Chronic Recurrent Multifocal Osteomyelitis

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Sources:
44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Chronic recurrent multifocal osteomyelitis (crmo) is an inflammatory bone condition. signs and symtpoms includeĀ recurrent episodes of pain and joint swelling, with or without fever. symptoms typicallyĀ begin in childhood. crmo may occur alone,Ā with psoriasis or inflammatory bowel disease, or as part of the syndromes, majeed syndrome or dira.Ā for most children, crmoĀ resolves after many yearsĀ without lasting effects. however, crmo can cause slow growth and permanent bone deformity. last updated: 5/15/2013

MalaCards: Chronic Recurrent Multifocal Osteomyelitis, also known as chronic multifocal osteomyelitis, is related to osteomyelitis and hypophosphatasia, and has symptoms including furuncle/cutaneous abscess/hidrosadenitis suppurativa, inflammatory intestinal disease and vascularitis/vasculitides/arteritis. An important gene associated with Chronic Recurrent Multifocal Osteomyelitis is LPIN2 (lipin 2), and among its related pathways are TNF-alpha/NF-kB Signaling Pathway and TNF Signaling. The compounds rantes and allergens have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and b cells, and related mouse phenotype other.

Wikipedia:66 Chronic recurrent multifocal osteomyelitis (CRMO) (\"multifocal\" because it can erupt in different... more...

Description from OMIM:48 259680

Aliases & Classifications for Chronic Recurrent Multifocal Osteomyelitis

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Sources:
44NIH Rare Diseases, 50Orphanet, 48OMIM, 63UMLS, 27ICD10 via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

50
chronic recurrent multifocal osteomyelitis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

chronic recurrent multifocal osteomyelitis 44 50 48
chronic multifocal osteomyelitis 44 63
crmo 44 50
multifocal osteomyelitis, chronic 44
cmo 44


External Ids:

OMIM48 259680
ICD10 via Orphanet27 M86.3
ICD1026 M86.3

Related Diseases for Chronic Recurrent Multifocal Osteomyelitis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Chronic Recurrent Multifocal Osteomyelitis:



Diseases related to chronic recurrent multifocal osteomyelitis

Symptoms for Chronic Recurrent Multifocal Osteomyelitis

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48OMIM, 50Orphanet
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Symptoms by clinical synopsis from OMIM:

259680

Clinical features from OMIM:

259680

Symptoms:

50 (show all 28)
  • furuncle/cutaneous abscess/hidrosadenitis suppurativa
  • inflammatory intestinal disease
  • vascularitis/vasculitides/arteritis
  • hyperostosis
  • anomalies of spine, vertebrae and pelvis
  • bone pain
  • sacroiliac joints anomalies
  • neuritis/polyneuritis/multineuritis
  • venous stenosis
  • palmoplantar pustulosis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • scoliosis
  • arthritis/synovitis/synovial proliferation
  • asthenia/fatigue/weakness
  • cranial nerves palsy
  • fever/chilling
  • anaemia
  • osteosclerosis/osteopetrosis/bone condensation
  • cutaneous rash
  • psoriasis
  • pruritus/itching
  • cutaneous edema
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • metaphyseal anomaly
  • acne/acnea
  • osteolysis/osteoclasia/bone destruction/erosions
  • epiphyseal anomaly

Drugs & Therapeutics for Chronic Recurrent Multifocal Osteomyelitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Chronic Recurrent Multifocal Osteomyelitis

Drug clinical trials:

Search ClinicalTrials for Chronic Recurrent Multifocal Osteomyelitis

Search NIH Clinical Center for Chronic Recurrent Multifocal Osteomyelitis

Search CenterWatch for Chronic Recurrent Multifocal Osteomyelitis

Genetic Tests for Chronic Recurrent Multifocal Osteomyelitis

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Anatomical Context for Chronic Recurrent Multifocal Osteomyelitis

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34MalaCards
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MalaCards organs/tissues related to Chronic Recurrent Multifocal Osteomyelitis:

34
Bone, Skin, B cells, Spinal cord, Testes, T cells

Animal Models for Chronic Recurrent Multifocal Osteomyelitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chronic Recurrent Multifocal Osteomyelitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.3CD40LG, ALPL

Publications for Chronic Recurrent Multifocal Osteomyelitis

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53PubMed
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Articles related to Chronic Recurrent Multifocal Osteomyelitis:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. (22961119)
2013
2
A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field. (24070048)
2013
3
Diagnostic difficulties: chronic recurrent multifocal osteomyelitis and lymphoma. One or two diseases? (22610142)
2013
4
Chronic recurrent multifocal osteomyelitis in a 13 year old female athlete: a case report. (24302781)
2013
5
Chronic recurrent multifocal osteomyelitis and deficiency of interleukin-1-receptor antagonist. (23241992)
2013
6
Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. (22359228)
2012
7
Normophosphatemic type tumoral calcinosis associated with chronic recurrent multifocal osteomyelitis: a case report. (21610312)
2011
8
Chronic recurrent multifocal osteomyelitis: a case report. (22946018)
2011
9
Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis. (21459961)
2011
10
Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate. (20339868)
2010
11
Chronic recurrent multifocal osteomyelitis primarily affecting the spine treated with anti-TNF therapy. (20228700)
2010
12
Chronic recurrent multifocal osteomyelitis as the first presentation of acute lymphoblastic leukemia in a 2-year-old boy. (20445409)
2010
13
Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia. (19335222)
2009
14
Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. (19567645)
2009
15
Chronic recurrent multifocal osteomyelitis of the first metatarsal bone: a case report. (19398809)
2009
16
Bisphosphonate treatment in chronic recurrent multifocal osteomyelitis. (18346517)
2008
17
Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature. (17912555)
2008
18
Chronic recurrent multifocal osteomyelitis. (18061969)
2007
19
Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. (17496555)
2007
20
Chronic recurrent multifocal osteomyelitis is a differential of childhood limp. (16371374)
2006
21
Chronic recurrent multifocal osteomyelitis of the spine and mandible: case report and review of the literature. (15060273)
2004
22
Residents' corner. Answer to case of the month #89. Chronic recurrent multifocal osteomyelitis as a presentation of SAPHO syndrome. (12866248)
2003
23
Chronic recurrent multifocal osteomyelitis: review of orthopaedic complications at maturity. (12131448)
2002
24
Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. (12183714)
2002
25
The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review. (11795677)
2001
26
Multifocal pyogranulomatous osteomyelitis resembling chronic recurrent multifocal osteomyelitis in a lemur. (11195834)
2001
27
Chronic recurrent multifocal osteomyelitis with Crohn's disease exacerbation and vasculitis after granulocyte colony-stimulating factor therapy. (19078487)
2000
28
Chronic recurrent multifocal osteomyelitis associated with ulcerative colitis: a case report. (11051168)
2000
29
Chronic recurrent multifocal osteomyelitis showing marked improvement with corticosteroid treatment. (10813311)
2000
30
Chronic recurrent multifocal osteomyelitis in children: diagnostic value of histopathology and microbial testing. (9923928)
1999
31
Chronic recurrent multifocal osteomyelitis--report of eight patients. (9880747)
1998
32
Chronic recurrent multifocal osteomyelitis involving both jaws: report of a case including magnetic resonance correlation. (9117765)
1997
33
Chronic recurrent multifocal osteomyelitis: an evolving clinical and radiological spectrum. (8737997)
1996
34
Chronic recurrent multifocal osteomyelitis (C.R.M.O.). A case report and review of literature. (8933140)
1996
35
Effective treatment with interferon-alpha in chronic recurrent multifocal osteomyelitis. (8564704)
1995
36
Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. (8034808)
1994
37
Case report: chronic recurrent multifocal osteomyelitis with magnetic resonance imaging. (8124893)
1994
38
Chronic recurrent multifocal osteomyelitis. (8451074)
1993
39
Chronic recurrent multifocal osteomyelitis: report of a case. (1554846)
1992
40
Chronic recurrent multifocal osteomyelitis in adult women. (1513515)
1992
41
Binding of bone sialoprotein to Staphylococcus epidermidis isolated from a patient with chronic recurrent multifocal osteomyelitis. (2319176)
1990
42
Chronic recurrent multifocal osteomyelitis. Association with vertebra plana. (2643605)
1989
43
Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings. (2809904)
1989
44
Physeal involvement in chronic recurrent multifocal osteomyelitis. (2602021)
1989
45
Chronic recurrent multifocal osteomyelitis in children. A roentgenologic and scintigraphic investigation. (3166878)
1988
46
Pustulotic arthroosteitis and chronic recurrent multifocal osteomyelitis in children. Report of three cases. (2965242)
1988
47
Chronic recurrent multifocal osteomyelitis and psoriasis--a report of a new association and review of related disorders. (2976529)
1988
48
Chronic recurrent multifocal osteomyelitis: a follow-up study. (3335622)
1988
49
Chronic recurrent multifocal osteomyelitis. A case report. (6480641)
1984
50
Pustulosis palmoplantaris and its relation to chronic recurrent multifocal osteomyelitis. (478042)
1979

Variations for Chronic Recurrent Multifocal Osteomyelitis

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Expression for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

Search GEO for disease gene expression data for Chronic Recurrent Multifocal Osteomyelitis.

Pathways for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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51PathCards, 39NCBI BioSystems Database, 58SinoBiological, 55R&D Systems, 31KEGG, 61Thomson Reuters, 54QIAGEN
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Compounds for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank
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Compounds related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes469.0CD40LG, CCL27
2allergens468.9CD40LG, CCL27
3hydroxyapatite468.8ALPL, CCL27, TNFRSF11A
4pge2468.6CD40LG, CCL27, TNFRSF11A
5aspartate468.5CCL27, ALPL, CD40LG
6dexamethasone46 52 30 1211.3CD40LG, CCL27, TNFRSF11A

GO Terms for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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17Gene Ontology
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Cellular components related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4CD40LG, TNFRSF11A
2extracellular spaceGO:0056158.2CD40LG, ALPL, CCL27

Biological processes related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.2ALPL, TNFRSF11A
2cell-cell signalingGO:0072679.2CCL27, TNFRSF11A

Products for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Recurrent Multifocal Osteomyelitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet