CMO
MCID: CHR288
MIFTS: 50

Chronic Recurrent Multifocal Osteomyelitis (CMO) malady

Rare diseases, Bone diseases, Skin diseases categories
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Summaries for Chronic Recurrent Multifocal Osteomyelitis

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NIH Rare Diseases:42 Chronic recurrent multifocal osteomyelitis (crmo) is an inflammatory bone condition. signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. symptoms typically begin in childhood. crmo may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, majeed syndrome or dira. for most children, crmo resolves after many years without lasting effects. however, crmo can cause slow growth and permanent bone deformity. last updated: 5/15/2013

MalaCards based summary: Chronic Recurrent Multifocal Osteomyelitis, also known as chronic multifocal osteomyelitis, is related to osteomyelitis and hypophosphatasia, and has symptoms including hyperostosis, osteomyelitis/osteitis/periostitis/spondylodisciitis and bone pain. An important gene associated with Chronic Recurrent Multifocal Osteomyelitis is LPIN2 (lipin 2), and among its related pathways are TNF-alpha/NF-kB Signaling Pathway and TNF Signaling. The compounds rantes and allergens have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spinal cord, and related mouse phenotype other.

Wikipedia:65 Chronic recurrent multifocal osteomyelitis (CRMO) (\"multifocal\" because it can erupt in different... more...

Description from OMIM:46 259680

Aliases & Classifications for Chronic Recurrent Multifocal Osteomyelitis

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Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 62UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Chronic Recurrent Multifocal Osteomyelitis, Aliases & Descriptions:

Name: Chronic Recurrent Multifocal Osteomyelitis 42 48 46 62
Chronic Multifocal Osteomyelitis 42 62
Crmo 42 48
 
Multifocal Osteomyelitis, Chronic 42
Cmo 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

48
chronic recurrent multifocal osteomyelitis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Childhood; Age of death: Normal


External Ids:

OMIM46 259680
ICD10 via Orphanet26 M86.3
ICD1025 M86.3

Related Diseases for Chronic Recurrent Multifocal Osteomyelitis

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Diseases related to Chronic Recurrent Multifocal Osteomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1osteomyelitis32.7LPIN2
2hypophosphatasia30.9ALPL
3majeed syndrome10.7
4arthritis10.5
5sapho syndrome10.5
6calcinosis10.5
7psoriasis10.5
8pyoderma10.5
9hypoaldosteronism, congenital, due to cmo ii deficiency10.4
10acne10.4
11crohn's disease10.4
12ulcerative colitis10.4
13congenital dyserythropoietic anemia10.4
14pyoderma gangrenosum10.4
15colitis10.4
1618 hydroxylase deficiency10.3
17acute lymphoblastic leukemia10.3
18b-cell lymphomas10.3
19leukemia10.3
20familial mediterranean fever10.3
21adult-onset still's disease10.3
22hyperostosis10.3
23lymphoblastic leukemia10.3
24synovitis10.3
25vasculitis10.3
26familial tumoral calcinosis10.3
27hip subluxation10.3
28hyperphosphatemic familial tumoral calcinosis10.3
29inflammatory bowel disease10.3
30pustulosis palmaris et plantaris10.3
31sickle cell anemia10.2
32corticosterone methyloxidase deficiency10.2
33hypoaldosteronism, congenital, due to cmo i deficiency10.2
34sjogren's syndrome10.1CCL27, CD40LG
35paget's disease of bone10.1TNFRSF11A, ALPL
36hypercalcemia10.1ALPL, TNFRSF11A
37enamel caries10.0
38secondary syphilis10.0ALPL, TNFRSF11A
39hepatitis b10.0ALPL, CCL27
40thrombocytopenia10.0CD40LG, ALPL
41hepatitis9.9CD40LG, CCL27
42osteoporosis9.9TNFRSF11A, ALPL
43ipex syndrome9.9CD40LG, CCL27, TNFRSF11A
44rheumatoid arthritis9.9TNFRSF11A, CCL27, CD40LG
45myeloma9.8CD40LG, ALPL, TNFRSF11A

Graphical network of the top 20 diseases related to Chronic Recurrent Multifocal Osteomyelitis:



Diseases related to chronic recurrent multifocal osteomyelitis

Symptoms for Chronic Recurrent Multifocal Osteomyelitis

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Symptoms by clinical synopsis from OMIM:

259680

Clinical features from OMIM:

259680

Symptoms:

48 (show all 28)
  • hyperostosis
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • bone pain
  • anomalies of spine, vertebrae and pelvis
  • furuncle/cutaneous abscess/hidrosadenitis suppurativa
  • cutaneous edema
  • osteosclerosis/osteopetrosis/bone condensation
  • osteolysis/osteoclasia/bone destruction/erosions
  • metaphyseal anomaly
  • epiphyseal anomaly
  • arthritis/synovitis/synovial proliferation
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • scoliosis
  • sacroiliac joints anomalies
  • palmoplantar pustulosis
  • cutaneous rash
  • psoriasis
  • pruritus/itching
  • acne/acnea
  • inflammatory intestinal disease
  • venous stenosis
  • vascularitis/vasculitides/arteritis
  • cranial nerves palsy
  • neuritis/polyneuritis/multineuritis
  • anaemia
  • fever/chilling

HPO human phenotypes related to Chronic Recurrent Multifocal Osteomyelitis:

(show all 27)
id Description Frequency HPO Source Accession
1 bone pain hallmark (90%) HP:0002653
2 osteomyelitis hallmark (90%) HP:0002754
3 hyperostosis hallmark (90%) HP:0100774
4 abnormality of the metaphyses typical (50%) HP:0000944
5 edema typical (50%) HP:0000969
6 arthritis typical (50%) HP:0001369
7 weight loss typical (50%) HP:0001824
8 osteolysis typical (50%) HP:0002797
9 abnormality of the epiphyses typical (50%) HP:0005930
10 increased bone mineral density typical (50%) HP:0011001
11 recurrent cutaneous abscess formation typical (50%) HP:0100838
12 skin rash occasional (7.5%) HP:0000988
13 pruritus occasional (7.5%) HP:0000989
14 acne occasional (7.5%) HP:0001061
15 polyneuropathy occasional (7.5%) HP:0001271
16 anemia occasional (7.5%) HP:0001903
17 inflammation of the large intestine occasional (7.5%) HP:0002037
18 vasculitis occasional (7.5%) HP:0002633
19 scoliosis occasional (7.5%) HP:0002650
20 psoriasis occasional (7.5%) HP:0003765
21 abnormality of temperature regulation occasional (7.5%) HP:0004370
22 venous thrombosis occasional (7.5%) HP:0004936
23 cranial nerve paralysis occasional (7.5%) HP:0006824
24 abnormality of the sacroiliac joint occasional (7.5%) HP:0100781
25 palmoplantar pustules occasional (7.5%) HP:0100847
26 abnormality of metabolism/homeostasis HP:0001939
27 chronic recurrent multifocal osteomyelitis HP:0005901

Drugs & Therapeutics for Chronic Recurrent Multifocal Osteomyelitis

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Drug clinical trials:

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Genetic Tests for Chronic Recurrent Multifocal Osteomyelitis

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Anatomical Context for Chronic Recurrent Multifocal Osteomyelitis

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MalaCards organs/tissues related to Chronic Recurrent Multifocal Osteomyelitis:

32
Bone, Skin, Spinal cord, Testes, T cells, B cells, Neutrophil

Animal Models for Chronic Recurrent Multifocal Osteomyelitis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Recurrent Multifocal Osteomyelitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.3CD40LG, ALPL

Publications for Chronic Recurrent Multifocal Osteomyelitis

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Articles related to Chronic Recurrent Multifocal Osteomyelitis:

(show top 50)    (show all 162)
idTitleAuthorsYear
1
GALNT3 gene mutation-associated chronic recurrent multifocal osteomyelitis and familial hyperphosphatemic familial tumoral calcinosis. (25351881)
2014
2
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. (22961119)
2013
3
A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field. (24070048)
2013
4
Diagnostic difficulties: chronic recurrent multifocal osteomyelitis and lymphoma. One or two diseases? (22610142)
2013
5
Chronic recurrent multifocal osteomyelitis in a 13 year old female athlete: a case report. (24302781)
2013
6
Chronic recurrent multifocal osteomyelitis and deficiency of interleukin-1-receptor antagonist. (23241992)
2013
7
Chronic Recurrent Multifocal Osteomyelitis in Children: A Multidisciplinary Approach is needed to establish a Diagnosis. (25165423)
2013
8
Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. (22359228)
2012
9
Normophosphatemic type tumoral calcinosis associated with chronic recurrent multifocal osteomyelitis: a case report. (21610312)
2011
10
Chronic recurrent multifocal osteomyelitis: a case report. (22946018)
2011
11
Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis. (21459961)
2011
12
Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate. (20339868)
2010
13
Chronic recurrent multifocal osteomyelitis primarily affecting the spine treated with anti-TNF therapy. (20228700)
2010
14
Chronic recurrent multifocal osteomyelitis as the first presentation of acute lymphoblastic leukemia in a 2-year-old boy. (20445409)
2010
15
Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia. (19335222)
2009
16
Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. (19567645)
2009
17
Chronic recurrent multifocal osteomyelitis of the first metatarsal bone: a case report. (19398809)
2009
18
Bisphosphonate treatment in chronic recurrent multifocal osteomyelitis. (18346517)
2008
19
Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature. (17912555)
2008
20
Chronic recurrent multifocal osteomyelitis. (18061969)
2007
21
Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. (17496555)
2007
22
Chronic recurrent multifocal osteomyelitis is a differential of childhood limp. (16371374)
2006
23
Chronic recurrent multifocal osteomyelitis of the spine and mandible: case report and review of the literature. (15060273)
2004
24
Residents' corner. Answer to case of the month #89. Chronic recurrent multifocal osteomyelitis as a presentation of SAPHO syndrome. (12866248)
2003
25
Chronic recurrent multifocal osteomyelitis: review of orthopaedic complications at maturity. (12131448)
2002
26
Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. (12183714)
2002
27
The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review. (11795677)
2001
28
Multifocal pyogranulomatous osteomyelitis resembling chronic recurrent multifocal osteomyelitis in a lemur. (11195834)
2001
29
Chronic recurrent multifocal osteomyelitis with Crohn's disease exacerbation and vasculitis after granulocyte colony-stimulating factor therapy. (19078487)
2000
30
Chronic recurrent multifocal osteomyelitis associated with ulcerative colitis: a case report. (11051168)
2000
31
Chronic recurrent multifocal osteomyelitis showing marked improvement with corticosteroid treatment. (10813311)
2000
32
Chronic recurrent multifocal osteomyelitis in children: diagnostic value of histopathology and microbial testing. (9923928)
1999
33
Chronic recurrent multifocal osteomyelitis--report of eight patients. (9880747)
1998
34
Chronic recurrent multifocal osteomyelitis involving both jaws: report of a case including magnetic resonance correlation. (9117765)
1997
35
Chronic recurrent multifocal osteomyelitis: an evolving clinical and radiological spectrum. (8737997)
1996
36
Chronic recurrent multifocal osteomyelitis (C.R.M.O.). A case report and review of literature. (8933140)
1996
37
Effective treatment with interferon-alpha in chronic recurrent multifocal osteomyelitis. (8564704)
1995
38
Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. (8034808)
1994
39
Chronic recurrent multifocal osteomyelitis. (8451074)
1993
40
Chronic recurrent multifocal osteomyelitis: report of a case. (1554846)
1992
41
Chronic recurrent multifocal osteomyelitis in adult women. (1513515)
1992
42
Binding of bone sialoprotein to Staphylococcus epidermidis isolated from a patient with chronic recurrent multifocal osteomyelitis. (2319176)
1990
43
Chronic recurrent multifocal osteomyelitis. Association with vertebra plana. (2643605)
1989
44
Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings. (2809904)
1989
45
Physeal involvement in chronic recurrent multifocal osteomyelitis. (2602021)
1989
46
Chronic recurrent multifocal osteomyelitis in children. A roentgenologic and scintigraphic investigation. (3166878)
1988
47
Pustulotic arthroosteitis and chronic recurrent multifocal osteomyelitis in children. Report of three cases. (2965242)
1988
48
Chronic recurrent multifocal osteomyelitis and psoriasis--a report of a new association and review of related disorders. (2976529)
1988
49
Chronic recurrent multifocal osteomyelitis. A case report. (6480641)
1984
50
Pustulosis palmoplantaris and its relation to chronic recurrent multifocal osteomyelitis. (478042)
1979

Variations for Chronic Recurrent Multifocal Osteomyelitis

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Expression for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Expression patterns in normal tissues for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

Search GEO for disease gene expression data for Chronic Recurrent Multifocal Osteomyelitis.

Pathways for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Compounds for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Sources:
44Novoseek, 50PharmGKB, 28IUPHAR, 11DrugBank
See all sources

Compounds related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes449.0CD40LG, CCL27
2allergens448.9CD40LG, CCL27
3hydroxyapatite448.8ALPL, CCL27, TNFRSF11A
4pge2448.6CD40LG, CCL27, TNFRSF11A
5aspartate448.5CCL27, ALPL, CD40LG
6dexamethasone44 50 28 1111.3CD40LG, CCL27, TNFRSF11A

GO Terms for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Cellular components related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4CD40LG, TNFRSF11A
2extracellular spaceGO:0056158.2CD40LG, ALPL, CCL27

Biological processes related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.2ALPL, TNFRSF11A
2cell-cell signalingGO:0072679.2CCL27, TNFRSF11A

Products for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Sources for Chronic Recurrent Multifocal Osteomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet