CMO
MCID: CHR288
MIFTS: 31

Chronic Recurrent Multifocal Osteomyelitis (CMO) malady

Bone diseases, Skin diseases categories

Summaries for Chronic Recurrent Multifocal Osteomyelitis

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Chronic recurrent multifocal osteomyelitis (crmo) is an inflammatory bone condition. signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. symptoms typically begin in childhood. crmo may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, majeed syndrome or dira. for most children, crmo resolves after many years without lasting effects. however, crmo can cause slow growth and permanent bone deformity. last updated: 5/15/2013

MalaCards: Chronic Recurrent Multifocal Osteomyelitis, also known as chronic multifocal osteomyelitis, is related to osteomyelitis and psoriasis. An important gene associated with Chronic Recurrent Multifocal Osteomyelitis is TNFRSF11A (tumor necrosis factor receptor superfamily, member 11a, NFKB activator), and among its related pathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and NF-kappa B signaling pathway. The compounds hydroxyapatite and allergens have been mentioned in the context of this disorder. Affiliated tissues include bone and skin.

Wikipedia:63 Chronic recurrent multifocal osteomyelitis (CRMO) (\"multifocal\" because it can erupt in different... more...

Description from OMIM:46 259680

Aliases & Classifications for Chronic Recurrent Multifocal Osteomyelitis

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42NIH Rare Diseases, 48Orphanet, 46OMIM, 60UMLS, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Skin diseases


Aliases & Descriptions:

chronic recurrent multifocal osteomyelitis 42 48 46
chronic multifocal osteomyelitis 42 60
crmo 42 48
multifocal osteomyelitis, chronic 42
cmo 42


External Ids:

OMIM46 259680
ICD10 via Orphanet26 M86.3
ICD1025 M86.3

Related Diseases for Chronic Recurrent Multifocal Osteomyelitis

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17GeneCards, 18GeneDecks
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Diseases in the Chronic Recurrent Multifocal Osteomyelitis family:

Juvenile Chronic Recurrent Multifocal Osteomyelitis Adult Chronic Recurrent Multifocal Osteomyelitis

Diseases related to Chronic Recurrent Multifocal Osteomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1osteomyelitis32.0LPIN2
2psoriasis30.7CCL27
3arthritis30.7ALPL, TNFRSF11A
4hypophosphatasia30.3ALPL
5inflammatory bowel disease30.3ALPL
6majeed syndrome10.6
7pyoderma10.5
8sapho syndrome10.5
9ulcerative colitis10.5
10pyoderma gangrenosum10.5
11crohn's disease10.4
12congenital dyserythropoietic anemia10.4
13bone lymphoma10.4
14acne10.4
15calcinosis10.4
16juvenile chronic recurrent multifocal osteomyelitis10.4
17adult chronic recurrent multifocal osteomyelitis10.4
18hypoaldosteronism, congenital, due to cmo ii deficiency10.4
19familial mediterranean fever10.2
20adult-onset still's disease10.2
21acute leukemia10.2
22hyperostosis10.2
23leukemia10.2
24lymphoblastic leukemia10.2
25synovitis10.2
26vasculitis10.2
27chronic granulomatous disease10.1
28sickle cell anemia10.1
29creatine transporter deficiency10.1
30hypoaldosteronism, congenital, due to cmo i deficiency10.1
31adult-onset sapho syndrome10.1
32juvenile-onset sapho syndrome10.1
3318 hydroxylase deficiency10.1
34enamel caries10.0
35corticosterone methyloxidase deficiency10.0
36mycosis fungoides10.0CCL27
37osteosclerosis10.0ALPL
38dengue hemorrhagic fever10.0CD40LG
39periodontal disease10.0ALPL
40deficiency anemia10.0ALPL
41osteomalacia10.0ALPL
42vascular disease10.0ALPL
43schistosomiasis10.0CD40LG
44cholelithiasis10.0ALPL
45arthropathy10.0ALPL
46hepatitis10.0CCL27, CD40LG
47hypercalcemia10.0TNFRSF11A, ALPL
48hepatitis b10.0CCL27, ALPL
49paget's disease of bone10.0TNFRSF11A, ALPL
50secondary syphilis10.0TNFRSF11A, ALPL

Graphical network of the top 20 diseases related to Chronic Recurrent Multifocal Osteomyelitis:



Diseases related to chronic recurrent multifocal osteomyelitis

Clinical Features for Chronic Recurrent Multifocal Osteomyelitis

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46OMIM
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Clinical features from OMIM:

259680

Clinical synopsis from OMIM:

259680

Drugs & Therapeutics for Chronic Recurrent Multifocal Osteomyelitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Chronic Recurrent Multifocal Osteomyelitis

Genetic Tests for Chronic Recurrent Multifocal Osteomyelitis

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Anatomical Context for Chronic Recurrent Multifocal Osteomyelitis

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32MalaCards
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MalaCards organs/tissues related to Chronic Recurrent Multifocal Osteomyelitis:

32
Bone, Skin

Animal Models for Chronic Recurrent Multifocal Osteomyelitis or affiliated genes

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Publications for Chronic Recurrent Multifocal Osteomyelitis

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Genetic Variations for Chronic Recurrent Multifocal Osteomyelitis

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Expression for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

Search GEO for disease gene expression data for Chronic Recurrent Multifocal Osteomyelitis.

Pathways for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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12EMD Millipore, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank
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Compounds related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hydroxyapatite448.8ALPL, TNFRSF11A, CCL27
2allergens448.7CD40LG, CCL27
3pge2448.6CD40LG, TNFRSF11A, CCL27
4dexamethasone44 49 28 1111.6CD40LG, TNFRSF11A, CCL27
5aspartate448.4CCL27, CD40LG, ALPL

GO Terms for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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16Gene Ontology
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Biological processes related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.5ALPL, TNFRSF11A

Products for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Recurrent Multifocal Osteomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet