CMO
MCID: CHR288
MIFTS: 36

Chronic Recurrent Multifocal Osteomyelitis (CMO) malady

Bone category

Summaries for Chronic Recurrent Multifocal Osteomyelitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Chronic recurrent multifocal osteomyelitis (crmo) is an inflammatory bone condition. signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. symptoms typically begin in childhood. crmo may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, majeed syndrome or dira. for most children, crmo resolves after many years without lasting effects. however, crmo can cause slow growth and permanent bone deformity. last updated: 5/15/2013

MalaCards: Chronic Recurrent Multifocal Osteomyelitis, also known as chronic multifocal osteomyelitis, is related to arthritis and hypophosphatasia. An important gene associated with Chronic Recurrent Multifocal Osteomyelitis is TNFRSF11A (tumor necrosis factor receptor superfamily, member 11a, NFKB activator), and among its related pathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and NF-kappa B signaling pathway. The compounds hydroxyapatite and allergens have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and t cells.

Wikipedia:64 Chronic recurrent multifocal osteomyelitis (CRMO) (\"multifocal\" because it can erupt in different... more...

Description from OMIM:47 259680

Aliases & Classifications for Chronic Recurrent Multifocal Osteomyelitis

Sources:
43NIH Rare Diseases, 49Orphanet, 47OMIM, 61UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

chronic recurrent multifocal osteomyelitis 43 49 47
chronic multifocal osteomyelitis 43 61
crmo 43 49
multifocal osteomyelitis, chronic 43
cmo 43


External Ids:

OMIM47 259680
ICD10 via Orphanet26 M86.3
ICD1025 M86.3

Related Diseases for Chronic Recurrent Multifocal Osteomyelitis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Chronic Recurrent Multifocal Osteomyelitis family:

juvenile chronic recurrent multifocal osteomyelitis adult chronic recurrent multifocal osteomyelitis

Diseases related to Chronic Recurrent Multifocal Osteomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.7ALPL, TNFRSF11A
2hypophosphatasia30.4ALPL
3majeed syndrome10.6
4adult chronic recurrent multifocal osteomyelitis10.6
5juvenile chronic recurrent multifocal osteomyelitis10.6
6sapho syndrome10.5
7ulcerative colitis10.5
8pyoderma gangrenosum10.5
9congenital dyserythropoietic anemia10.4
10bone lymphoma10.4
11acne10.4
12chronic pain10.4
13hypoaldosteronism, congenital, due to cmo ii deficiency10.4
14crohn's disease10.3
15familial mediterranean fever10.3
16adult-onset still's disease10.3
17n syndrome10.3
18acute leukemia10.3
19synovitis10.3
20vasculitis10.3
21pediatric ulcerative colitis10.3
22synovitis, chronic10.3
23primary bone lymphoma10.3
24chronic granulomatous disease10.2
25sickle cell anemia10.2
26creatine transporter deficiency10.2
27clostridium difficile10.2
28hypoaldosteronism, congenital, due to cmo i deficiency10.2
2918 hydroxylase deficiency10.2
30enamel caries10.0
31corticosterone methyloxidase deficiency10.0
32osteomyelitis10.0LPIN2
33psoriasis10.0CCL27
34mycosis fungoides10.0CCL27
35osteosclerosis10.0ALPL
36dengue hemorrhagic fever10.0CD40LG
37periodontal disease10.0ALPL
38deficiency anemia10.0ALPL
39osteomalacia10.0ALPL
40vascular disease10.0ALPL
41schistosomiasis10.0CD40LG
42cholelithiasis10.0ALPL
43arthropathy10.0ALPL
44hepatitis10.0CCL27, CD40LG
45inflammatory bowel disease10.0ALPL
46hypercalcemia10.0TNFRSF11A, ALPL
47hepatitis b10.0CCL27, ALPL
48paget's disease of bone10.0TNFRSF11A, ALPL
49secondary syphilis10.0TNFRSF11A, ALPL
50rheumatoid arthritis10.0CD40LG, TNFRSF11A, CCL27

Graphical network of the top 20 diseases related to Chronic Recurrent Multifocal Osteomyelitis:



Diseases related to chronic recurrent multifocal osteomyelitis

Clinical Features for Chronic Recurrent Multifocal Osteomyelitis

Sources:
47OMIM
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Clinical features from OMIM:

259680

Clinical synopsis from OMIM:

259680

Drugs & Therapeutics for Chronic Recurrent Multifocal Osteomyelitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Chronic Recurrent Multifocal Osteomyelitis

Drug clinical trials:

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Search NIH Clinical Center for Chronic Recurrent Multifocal Osteomyelitis

Search CenterWatch for Chronic Recurrent Multifocal Osteomyelitis

Genetic Tests for Chronic Recurrent Multifocal Osteomyelitis

Anatomical Context for Chronic Recurrent Multifocal Osteomyelitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Chronic Recurrent Multifocal Osteomyelitis:

33
Spinal cord, Skin, T cells, B lymphoblasts, B cells

Animal Models for Chronic Recurrent Multifocal Osteomyelitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Chronic Recurrent Multifocal Osteomyelitis

Sources:
51PubMed
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Articles related to Chronic Recurrent Multifocal Osteomyelitis:

(show top 50)    (show all 159)
idTitleAuthorsYear
1
Chronic recurrent multifocal osteomyelitis. (23695372)
2013
2
Chronic recurrent multifocal osteomyelitis causing an acute scoliosis. (23997974)
2013
3
Unusual presentation of spinal involvement in a child with chronic recurrent multifocal osteomyelitis. (23992272)
2013
4
Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). (24359092)
2013
5
Schnitzler's disease as an important differential diagnosis of chronic recurrent multifocal osteomyelitis: a case report. (22937451)
2012
6
Adult-onset Still's disease and chronic recurrent multifocal osteomyelitis: a hitherto undescribed manifestation of autoinflammation. (21769488)
2012
7
Chronic recurrent multifocal osteomyelitis mimicking osteoid osteoma. (23019997)
2012
8
Chronic recurrent multifocal osteomyelitis: a case report and review of literature. (22786864)
2011
9
A 14-year-old boy with mandibular tumor, spontaneous spinal fractures. Chronic recurrent multifocal osteomyelitis. (21485994)
2011
10
Chronic recurrent multifocal osteomyelitis with concomitant features of juvenile idiopathic arthritis. (22937441)
2011
11
Granulomatous pyoderma preceding chronic recurrent multifocal osteomyelitis triggered by vaccinations in a two-year-old boy: a case report. (20955551)
2010
12
Chronic recurrent multifocal osteomyelitis of the first metatarsal bone: a case report. (19398809)
2009
13
Chronic recurrent multifocal osteomyelitis (CRMO) and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome with associated neutrophilic dermatoses: a report of seven cases and review of the literature. (19840301)
2009
14
Case report: Chronic recurrent multifocal osteomyelitis: a case report and role of whole-body MRI. (19414089)
2009
15
A case of chronic recurrent multifocal osteomyelitis successfully treated with neridronate. (19187751)
2009
16
Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO). (19138427)
2009
17
Chronic recurrent multifocal osteomyelitis in a patient with selective immunoglobulin M deficiency. (19034453)
2009
18
Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature. (17912555)
2008
19
Chronic recurrent multifocal osteomyelitis (CRMO). (18661712)
2008
20
Chronic recurrent multifocal osteomyelitis is a differential of childhood limp. (16371374)
2006
21
Chronic recurrent multifocal osteomyelitis. (15697165)
2005
22
Chronic recurrent multifocal osteomyelitis: two cases of sacral disease responsive to corticosteroids. (15712088)
2005
23
Imaging of chronic recurrent multifocal osteomyelitis of childhood first presenting with isolated primary spinal involvement. (12761599)
2003
24
Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. (12183714)
2002
25
The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review. (11795677)
2001
26
Multifocal pyogranulomatous osteomyelitis resembling chronic recurrent multifocal osteomyelitis in a lemur. (11195834)
2001
27
Acne with chronic recurrent multifocal osteomyelitis involving the mandible as part of the SAPHO syndrome: case report. (11286450)
2001
28
Imaging of chronic recurrent multifocal osteomyelitis. (11316361)
2001
29
Chronic recurrent multifocal osteomyelitis: five-year outcomes in 14 pediatric cases. (11394625)
2001
30
Premature epiphyseal fusion and degenerative arthritis in chronic recurrent multifocal osteomyelitis. (10741498)
2000
31
Chronic recurrent multifocal osteomyelitis. (10511196)
1999
32
Chronic recurrent multifocal osteomyelitis: a great clinical and radiologic mimic in need of recognition by the pathologist. (10230689)
1999
33
Skin ulcers associated with a tender and swollen arm. Pyoderma gangrenosum (PG) in association with chronic recurrent multifocal osteomyelitis (CRMO). (9762031)
1998
34
Chronic recurrent multifocal osteomyelitis causing spinal cord compression. (9765044)
1998
35
Chronic recurrent multifocal osteomyelitis: an evolving clinical and radiological spectrum. (8737997)
1996
36
Chronic recurrent multifocal osteomyelitis (C.R.M.O.). A case report and review of literature. (8933140)
1996
37
Chronic recurrent multifocal osteomyelitis: spinal involvement and radiological appearances. (8883445)
1996
38
Two cases of chronic recurrent multifocal osteomyelitis: radiological and scintigraphic findings. (8996908)
1996
39
Chronic recurrent multifocal osteomyelitis associated with tumoral calcinosis. (8113304)
1994
40
Chronic recurrent multifocal osteomyelitis involving the mandible. (7936583)
1994
41
Chronic recurrent multifocal osteomyelitis. (8451074)
1993
42
Chronic recurrent multifocal osteomyelitis in adult women. (1513515)
1992
43
Binding of bone sialoprotein to Staphylococcus epidermidis isolated from a patient with chronic recurrent multifocal osteomyelitis. (2319176)
1990
44
Physeal and epiphyseal involvement in chronic recurrent multifocal osteomyelitis (CRMO) (2216601)
1990
45
Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings. (2809904)
1989
46
Pustulotic arthroosteitis and chronic recurrent multifocal osteomyelitis in children. Report of three cases. (2965242)
1988
47
Sweet's syndrome and chronic recurrent multifocal osteomyelitis. (3591758)
1987
48
Chronic recurrent multifocal osteomyelitis: are mycoplasmas involved? (3614302)
1987
49
Chronic recurrent multifocal osteomyelitis. A case report. (6480641)
1984
50
Pustulosis palmoplantaris and its relation to chronic recurrent multifocal osteomyelitis. (478042)
1979

Genetic Variations for Chronic Recurrent Multifocal Osteomyelitis

Expression for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

Search GEO for disease gene expression data for Chronic Recurrent Multifocal Osteomyelitis.

Pathways for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

Sources:
12EMD Millipore, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank
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Compounds related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hydroxyapatite458.8ALPL, TNFRSF11A, CCL27
2allergens458.7CD40LG, CCL27
3pge2458.6CD40LG, TNFRSF11A, CCL27
4dexamethasone45 50 29 1111.6CD40LG, TNFRSF11A, CCL27
5aspartate458.4CCL27, CD40LG, ALPL

GO Terms for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

Sources:
16Gene Ontology
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Biological processes related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.5ALPL, TNFRSF11A

Products for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Sources for Chronic Recurrent Multifocal Osteomyelitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet