CMO
MCID: CHR288
MIFTS: 45

Chronic Recurrent Multifocal Osteomyelitis (CMO) malady

Categories: Rare diseases, Bone diseases, Skin diseases

Aliases & Classifications for Chronic Recurrent Multifocal Osteomyelitis

Aliases & Descriptions for Chronic Recurrent Multifocal Osteomyelitis:

Name: Chronic Recurrent Multifocal Osteomyelitis 54 12 50 56 14
Chronic Multifocal Osteomyelitis 12 50 69
Crmo 12 50 56
Multifocal Osteomyelitis, Chronic 50
Cmo 50

Characteristics:

Orphanet epidemiological data:

56
chronic recurrent multifocal osteomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide),1-9/100000 (Worldwide); Age of onset: Adolescent,Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

OMIM 54 259680
Disease Ontology 12 DOID:0060645
ICD10 33 M86.3
Orphanet 56 ORPHA324964
ICD10 via Orphanet 34 M86.3

Summaries for Chronic Recurrent Multifocal Osteomyelitis

NIH Rare Diseases : 50 chronic recurrent multifocal osteomyelitis (crmo) is an inflammatory bone condition. signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. symptoms typically begin in childhood. crmo may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, majeed syndrome or dira. for most children, crmo resolves after many years without lasting effects. however, crmo can cause slow growth and permanent bone deformity. last updated: 5/15/2013

MalaCards based summary : Chronic Recurrent Multifocal Osteomyelitis, also known as chronic multifocal osteomyelitis, is related to majeed syndrome and hypoaldosteronism, congenital, due to cmo i deficiency, and has symptoms including pruritus, fatigue and edema. An important gene associated with Chronic Recurrent Multifocal Osteomyelitis is LPIN2 (Lipin 2), and among its related pathways/superpathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Salmonella infection (KEGG). The drug Pamidronate has been mentioned in the context of this disorder. Affiliated tissues include bone, skin and t cells, and related phenotype is Synthetic lethal with MLN4924 (a NAE inhibitor).

Disease Ontology : 12 An osteomyelitis characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine.

Wikipedia : 71 Chronic recurrent multifocal osteomyelitis (CRMO) (\"multifocal\" because it can erupt in different... more...

Description from OMIM: 259680

Related Diseases for Chronic Recurrent Multifocal Osteomyelitis

Diseases related to Chronic Recurrent Multifocal Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
id Related Disease Score Top Affiliating Genes
1 majeed syndrome 12.3
2 hypoaldosteronism, congenital, due to cmo i deficiency 12.2
3 hypoaldosteronism, congenital, due to cmo ii deficiency 12.2
4 osteomyelitis 10.9
5 corticosterone methyloxidase deficiency 10.8
6 amelanotic melanoma 10.1 CASP1 IL1B
7 muckle-wells syndrome 10.1 CASP1 IL1B
8 giant cell glioblastoma 10.1 CASP1 IL1B
9 familial hyperthyroidism due to mutations in tsh receptor 10.1 CASP1 IL1B
10 pyoderma 10.1
11 cinca syndrome 10.1 CASP1 IL1B
12 pyloric stenosis, infantile hypertrophic, 2 10.1 CASP1 IL1B
13 isolated growth hormone deficiency 10.1 CASP1 IL1B
14 wilkes stevenson syndrome 10.1 CASP1 IL1B
15 keratomalacia 10.1 CASP1 IL1B
16 pyoderma gangrenosum 10.0
17 arthritis 10.0
18 crohn's disease 10.0
19 dentin caries 10.0 CASP1 PYCARD
20 lymphoma 10.0
21 colitis 10.0
22 psoriasis 10.0
23 sapho syndrome 10.0
24 calcinosis 10.0
25 ulcerative colitis 10.0
26 mental retardation, autosomal dominant 22 10.0 CASP1 IL1B PYCARD
27 rift valley fever 9.9 CASP1 IL1B
28 enamel caries 9.9
29 inflammatory bowel disease 9.9
30 scoliosis 9.9
31 congenital dyserythropoietic anemia 9.9
32 acne 9.9
33 classic type lipoma 9.8 ALPL CASP1 IL1B LPIN2
34 vasculitis 9.7
35 familial tumoral calcinosis 9.7
36 hip subluxation 9.7
37 lymphoblastic leukemia 9.7
38 pustular psoriasis 9.7
39 pustulosis palmaris et plantaris 9.7
40 takayasu arteritis 9.7
41 hypophosphatasia 9.7
42 adult-onset still's disease 9.7
43 b-cell lymphomas 9.7
44 hyperostosis 9.7
45 chronic granulomatous disease 9.7
46 synovitis 9.7
47 leukemia 9.7
48 tuberculosis 9.7
49 chromosome 16p11.2 duplication syndrome autism, susceptibility to, 14b, included 8.9 ALPL CASP1 CCL27 CPT1B IL1B KIAA1468

Graphical network of the top 20 diseases related to Chronic Recurrent Multifocal Osteomyelitis:



Diseases related to Chronic Recurrent Multifocal Osteomyelitis

Symptoms & Phenotypes for Chronic Recurrent Multifocal Osteomyelitis

Symptoms by clinical synopsis from OMIM:

259680

Clinical features from OMIM:

259680

Human phenotypes related to Chronic Recurrent Multifocal Osteomyelitis:

56 32 (show all 29)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 56 32 Occasional (29-5%) HP:0000989
2 fatigue 56 32 Frequent (79-30%) HP:0012378
3 edema 56 32 Frequent (79-30%) HP:0000969
4 fever 56 32 Occasional (29-5%) HP:0001945
5 bone pain 56 32 Very frequent (99-80%) HP:0002653
6 abnormality of epiphysis morphology 56 32 Frequent (79-30%) HP:0005930
7 scoliosis 56 32 Occasional (29-5%) HP:0002650
8 arthritis 56 32 Frequent (79-30%) HP:0001369
9 abnormality of the vertebrae 56 32 Frequent (79-30%) HP:0003468
10 cranial nerve paralysis 56 32 Occasional (29-5%) HP:0006824
11 anemia 56 32 Occasional (29-5%) HP:0001903
12 weight loss 56 32 Frequent (79-30%) HP:0001824
13 abnormality of the metaphyses 56 32 Frequent (79-30%) HP:0000944
14 acne 56 32 Occasional (29-5%) HP:0001061
15 inflammation of the large intestine 56 32 Occasional (29-5%) HP:0002037
16 osteomyelitis 56 32 Very frequent (99-80%) HP:0002754
17 skin rash 56 32 Occasional (29-5%) HP:0000988
18 vasculitis 56 32 Occasional (29-5%) HP:0002633
19 hyperostosis 56 32 Very frequent (99-80%) HP:0100774
20 osteolysis 56 32 Frequent (79-30%) HP:0002797
21 elevated c-reactive protein level 56 32 Frequent (79-30%) HP:0011227
22 abnormality of the sacroiliac joint 56 32 Occasional (29-5%) HP:0100781
23 elevated erythrocyte sedimentation rate 56 32 Frequent (79-30%) HP:0003565
24 poor appetite 56 32 Frequent (79-30%) HP:0004396
25 craniofacial osteosclerosis 56 32 Frequent (79-30%) HP:0005464
26 psoriasis 56 32 Occasional (29-5%) HP:0003765
27 palmoplantar pustulosis 56 32 Occasional (29-5%) HP:0100847
28 abnormality of metabolism/homeostasis 32 HP:0001939
29 chronic recurrent multifocal osteomyelitis 32 HP:0005901

GenomeRNAi Phenotypes related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CASP1 IL1B KIAA1468 PYCARD
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CASP1 IL1B KIAA1468 PYCARD

Drugs & Therapeutics for Chronic Recurrent Multifocal Osteomyelitis

Drugs for Chronic Recurrent Multifocal Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pamidronate Approved Phase 2 40391-99-9 4674

Interventional clinical trials:


id Name Status NCT ID Phase
1 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate Recruiting NCT02594878 Phase 2

Search NIH Clinical Center for Chronic Recurrent Multifocal Osteomyelitis

Genetic Tests for Chronic Recurrent Multifocal Osteomyelitis

Anatomical Context for Chronic Recurrent Multifocal Osteomyelitis

MalaCards organs/tissues related to Chronic Recurrent Multifocal Osteomyelitis:

39
Bone, Skin, T Cells, Testes, Neutrophil, B Cells, Spinal Cord

Publications for Chronic Recurrent Multifocal Osteomyelitis

Articles related to Chronic Recurrent Multifocal Osteomyelitis:

(show top 50) (show all 195)
id Title Authors Year
1
An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis. ( 28042129 )
2017
2
Chronic Recurrent Multifocal Osteomyelitis in Crohn's Disease - Complete Resolution with Anti TNFI+ Therapy. ( 27050047 )
2016
3
Chronic recurrent multifocal osteomyelitis (CRMO) - advancing the diagnosis. ( 27576444 )
2016
4
Chronic recurrent multifocal osteomyelitis with isolated spinal involvement. ( 27156159 )
2016
5
Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO). ( 27000045 )
2016
6
Successful treatment of chronic recurrent multifocal osteomyelitis using low-dose radiotherapy : A case report. ( 27822735 )
2016
7
Chronic recurrent multifocal osteomyelitis with isolated spinal involvement. ( 27606479 )
2016
8
Chronic Recurrent Multifocal Osteomyelitis and Thalidomide in Chronic Granulomatous Disease. ( 27436506 )
2016
9
Chronic recurrent multifocal osteomyelitis in association with pyoderma gangraenosum. ( 27585859 )
2016
10
Whole-Body Diffusion-Weighted Imaging in Chronic Recurrent Multifocal Osteomyelitis in Children. ( 26799970 )
2016
11
Chronic recurrent multifocal osteomyelitis in children: nine years' experience at a statewide tertiary paediatric rheumatology referral centre. ( 25936788 )
2015
12
Chronic recurrent multifocal osteomyelitis and inflammatory bowel disease. ( 25493348 )
2015
13
Etanercept treatment in five cases of refractory chronic recurrent multifocal osteomyelitis (CRMO). ( 26184538 )
2015
14
Whole-body Magnetic Resonance Imaging in Chronic Recurrent Multifocal Osteomyelitis: Clinical Longterm Assessment May Underestimate Activity. ( 25979713 )
2015
15
Chronic recurrent multifocal osteomyelitis with an atypical presentation in an adult man. ( 25771734 )
2015
16
Chronic recurrent multifocal osteomyelitis. ( 25701475 )
2015
17
Chronic recurrent multifocal osteomyelitis: A rare entity. ( 25898848 )
2015
18
Clinical outcome in a Norwegian cohort of patients with chronic recurrent multifocal osteomyelitis. ( 26312400 )
2015
19
Chronic recurrent multifocal osteomyelitis: a rare skeletal disorder. ( 26307646 )
2015
20
Unusual onset of a case of chronic recurrent multifocal osteomyelitis. ( 26653878 )
2015
21
Skull involvement in a pediatric case of chronic recurrent multifocal osteomyelitis. ( 26412896 )
2015
22
Parotid swelling and chronic recurrent multifocal osteomyelitis of mandible in children. ( 25468462 )
2015
23
The Contributions of Whole-body Magnetic Resonance Imaging for the Diagnosis and Management of Chronic Recurrent Multifocal Osteomyelitis. ( 26233948 )
2015
24
A case of chronic recurrent multifocal osteomyelitis associated with crohn's disease. ( 26151695 )
2015
25
Caseous granuloma: tuberculosis or chronic recurrent multifocal osteomyelitis? ( 26019785 )
2014
26
Chronic recurrent multifocal osteomyelitis manifested as painful clavicular swelling: a case report. ( 25374147 )
2014
27
Chronic recurrent multifocal osteomyelitis: the prevalence of lower-limb and foot involvement. ( 25514269 )
2014
28
Deregulation of the IL-1I^ axis in chronic recurrent multifocal osteomyelitis. ( 25061439 )
2014
29
Retracted: chronic recurrent multifocal osteomyelitis with concomitant features of juvenile idiopathic arthritis. ( 25543994 )
2014
30
Chronic recurrent multifocal osteomyelitis complicated by hip subluxation: a case report. ( 25123421 )
2014
31
Chronic recurrent multifocal osteomyelitis (CRMO) in children - single-centre clinical observations and experience. ( 25058105 )
2014
32
99mTc-HMPAO-Labeled WBC Scan for the Diagnosis of Chronic Recurrent Multifocal Osteomyelitis. ( 25168250 )
2014
33
Skin manifestations associated with chronic recurrent multifocal osteomyelitis in a 9-year-old girl. ( 25438001 )
2014
34
GALNT3 gene mutation-associated chronic recurrent multifocal osteomyelitis and familial hyperphosphatemic familial tumoral calcinosis. ( 25351881 )
2014
35
Chronic recurrent multifocal osteomyelitis: typical patterns of bone involvement in whole-body bone scintigraphy. ( 24736329 )
2014
36
Chronic recurrent multifocal osteomyelitis in a 13 year old female athlete: a case report. ( 24302781 )
2013
37
Chronic Recurrent Multifocal Osteomyelitis in Children: A Multidisciplinary Approach is needed to establish a Diagnosis. ( 25165423 )
2013
38
A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field. ( 24070048 )
2013
39
Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). ( 24359092 )
2013
40
Chronic recurrent multifocal osteomyelitis. ( 23695372 )
2013
41
Unusual presentation of spinal involvement in a child with chronic recurrent multifocal osteomyelitis. ( 23992272 )
2013
42
Chronic recurrent multifocal osteomyelitis and deficiency of interleukin-1-receptor antagonist. ( 23241992 )
2013
43
Typical patterns of bone involvement in whole-body MRI of patients with chronic recurrent multifocal osteomyelitis (CRMO). ( 23696017 )
2013
44
Diagnostic difficulties: chronic recurrent multifocal osteomyelitis and lymphoma. One or two diseases? ( 22610142 )
2013
45
Chronic recurrent multifocal osteomyelitis (CRMO): a longitudinal case series review. ( 23263195 )
2013
46
Chronic recurrent multifocal osteomyelitis causing an acute scoliosis. ( 23997974 )
2013
47
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. ( 22961119 )
2013
48
Bisphosphonate therapy for chronic recurrent multifocal osteomyelitis. ( 23624726 )
2013
49
Chronic recurrent multifocal osteomyelitis. ( 23654059 )
2013
50
Tibial stress fracture simulate osteomyelitic foci in the course of chronic recurrent multifocal osteomyelitis. ( 24611355 )
2013

Variations for Chronic Recurrent Multifocal Osteomyelitis

Expression for Chronic Recurrent Multifocal Osteomyelitis

Search GEO for disease gene expression data for Chronic Recurrent Multifocal Osteomyelitis.

Pathways for Chronic Recurrent Multifocal Osteomyelitis

GO Terms for Chronic Recurrent Multifocal Osteomyelitis

Cellular components related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NLRP3 inflammasome complex GO:0072559 9.16 CASP1 PYCARD
2 AIM2 inflammasome complex GO:0097169 8.96 CASP1 PYCARD
3 NLRP1 inflammasome complex GO:0072558 8.62 CASP1 PYCARD

Biological processes related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.52 CASP1 PYCARD
2 cellular response to mechanical stimulus GO:0071260 9.51 CASP1 IL1B
3 response to lipopolysaccharide GO:0032496 9.5 ALPL CASP1 IL1B
4 cellular response to organic cyclic compound GO:0071407 9.49 ALPL IL1B
5 positive regulation of JNK cascade GO:0046330 9.48 IL1B PYCARD
6 positive regulation of interferon-gamma production GO:0032729 9.46 IL1B PYCARD
7 positive regulation of interleukin-6 production GO:0032755 9.43 IL1B PYCARD
8 cellular response to organic substance GO:0071310 9.4 CASP1 IL1B
9 positive regulation of phagocytosis GO:0050766 9.37 IL1B PYCARD
10 positive regulation of interleukin-1 beta secretion GO:0050718 9.26 CASP1 PYCARD
11 positive regulation of interleukin-6 secretion GO:2000778 9.16 IL1B PYCARD
12 response to ATP GO:0033198 8.96 CASP1 IL1B
13 interleukin-1 beta production GO:0032611 8.62 CASP1 IL1B

Molecular functions related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 8.62 CASP1 PYCARD

Sources for Chronic Recurrent Multifocal Osteomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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