MCID: CHR288
MIFTS: 47

Chronic Recurrent Multifocal Osteomyelitis malady

Categories: Rare diseases, Bone diseases, Skin diseases

Aliases & Classifications for Chronic Recurrent Multifocal Osteomyelitis

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Chronic Recurrent Multifocal Osteomyelitis:

Name: Chronic Recurrent Multifocal Osteomyelitis 45 51
Chronic Multifocal Osteomyelitis 45 65
Crmo 45 51
 
Multifocal Osteomyelitis, Chronic 45
Cmo 45

Characteristics:

Orphanet epidemiological data:

51
chronic recurrent multifocal osteomyelitis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide),1-9/100000 (Worldwide); Age of onset: Adolescent,Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 324964
ICD10 via Orphanet28 M86.3
ICD1027 M86.3
UMLS65 C0410422

Summaries for Chronic Recurrent Multifocal Osteomyelitis

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NIH Rare Diseases:45 Chronic recurrent multifocal osteomyelitis (crmo) is an inflammatory bone condition. signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. symptoms typically begin in childhood. crmo may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, majeed syndrome or dira. for most children, crmo resolves after many years without lasting effects. however, crmo can cause slow growth and permanent bone deformity. last updated: 5/15/2013

MalaCards based summary: Chronic Recurrent Multifocal Osteomyelitis, also known as chronic multifocal osteomyelitis, is related to hypoaldosteronism, congenital, due to cmo ii deficiency and majeed syndrome, and has symptoms including hyperostosis, osteomyelitis and bone pain. An important gene associated with Chronic Recurrent Multifocal Osteomyelitis is LPIN2 (Lipin 2), and among its related pathways are Cellular roles of Anthrax toxin and Immune response IFN gamma signaling pathway. Affiliated tissues include bone, skin and breast, and related mouse phenotype hematopoietic system.

Wikipedia:68 Chronic recurrent multifocal osteomyelitis (CRMO) (\"multifocal\" because it can erupt in different... more...

Related Diseases for Chronic Recurrent Multifocal Osteomyelitis

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Diseases related to Chronic Recurrent Multifocal Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1hypoaldosteronism, congenital, due to cmo ii deficiency12.2
2majeed syndrome12.2
3hypoaldosteronism, congenital, due to cmo i deficiency12.2
4osteomyelitis11.0
5corticosterone methyloxidase deficiency10.9
6arthritis10.1
7crohn's disease10.1
8pyoderma10.1
9ulcerative colitis10.1
10lymphoma10.1
11colitis10.1
12sapho syndrome10.1
13calcinosis10.1
14pyoderma gangrenosum10.1
15psoriasis10.1
16enamel caries10.0
17acne10.0
18scoliosis10.0
19congenital dyserythropoietic anemia10.0
20tinea capitis10.0CASP1, IL1B
21familial cold-induced inflammatory syndrome 19.9CASP1, IL1B
22glioblastoma multiforme9.9CASP1, IL1B
23muckle-wells syndrome9.9CASP1, IL1B
24diversion colitis9.9CASP1, IL1B
25b-cell lymphomas9.8
26leukemia9.8
27lymphoblastic leukemia9.8
28hypophosphatasia9.8
29adult-onset still's disease9.8
30hyperostosis9.8
31synovitis9.8
32tuberculosis9.8
33vasculitis9.8
34familial tumoral calcinosis9.8
35hip subluxation9.8
36pustular psoriasis9.8
37pustulosis palmaris et plantaris9.8
38mitochondrial metabolism disease9.8ALPL, IL1B
39balantidiasis9.8CASP1, IL1B
40porphyria9.7CASP1, IL1B
41common cold9.6CASP1, PYCARD
42long bone adamantinoma9.6CCL27, IL1B
43rectum signet ring adenocarcinoma9.6ALPL, IL1B
44liver lipoma9.2ALPL, CASP1, IL1B, LPIN2
45cinca syndrome9.2CASP1, IL1B, PYCARD
46chudley rozdilsky syndrome7.5ALPL, CASP1, CCL27, IL1B, KIAA1468, LPIN2

Graphical network of the top 20 diseases related to Chronic Recurrent Multifocal Osteomyelitis:



Diseases related to chronic recurrent multifocal osteomyelitis

Symptoms for Chronic Recurrent Multifocal Osteomyelitis

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Symptoms:

 51 (show all 28)
  • hyperostosis
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • bone pain
  • anomalies of spine, vertebrae and pelvis
  • furuncle/cutaneous abscess/hidrosadenitis suppurativa
  • cutaneous edema
  • osteosclerosis/osteopetrosis/bone condensation
  • osteolysis/osteoclasia/bone destruction/erosions
  • metaphyseal anomaly
  • epiphyseal anomaly
  • arthritis/synovitis/synovial proliferation
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • scoliosis
  • sacroiliac joints anomalies
  • palmoplantar pustulosis
  • cutaneous rash
  • psoriasis
  • pruritus/itching
  • acne/acnea
  • inflammatory intestinal disease
  • venous stenosis
  • vascularitis/vasculitides/arteritis
  • cranial nerves palsy
  • neuritis/polyneuritis/multineuritis
  • anaemia
  • fever/chilling

HPO human phenotypes related to Chronic Recurrent Multifocal Osteomyelitis:

(show all 27)
id Description Frequency HPO Source Accession
1 hyperostosis hallmark (90%) HP:0100774
2 osteomyelitis hallmark (90%) HP:0002754
3 bone pain hallmark (90%) HP:0002653
4 recurrent cutaneous abscess formation typical (50%) HP:0100838
5 increased bone mineral density typical (50%) HP:0011001
6 abnormality of epiphysis morphology typical (50%) HP:0005930
7 osteolysis typical (50%) HP:0002797
8 weight loss typical (50%) HP:0001824
9 arthritis typical (50%) HP:0001369
10 edema typical (50%) HP:0000969
11 abnormality of the metaphyses typical (50%) HP:0000944
12 palmoplantar pustulosis occasional (7.5%) HP:0100847
13 abnormality of the sacroiliac joint occasional (7.5%) HP:0100781
14 cranial nerve paralysis occasional (7.5%) HP:0006824
15 venous thrombosis occasional (7.5%) HP:0004936
16 abnormality of temperature regulation occasional (7.5%) HP:0004370
17 psoriasis occasional (7.5%) HP:0003765
18 scoliosis occasional (7.5%) HP:0002650
19 vasculitis occasional (7.5%) HP:0002633
20 inflammation of the large intestine occasional (7.5%) HP:0002037
21 anemia occasional (7.5%) HP:0001903
22 polyneuropathy occasional (7.5%) HP:0001271
23 acne occasional (7.5%) HP:0001061
24 pruritus occasional (7.5%) HP:0000989
25 skin rash occasional (7.5%) HP:0000988
26 chronic recurrent multifocal osteomyelitis HP:0005901
27 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Chronic Recurrent Multifocal Osteomyelitis

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Drugs for Chronic Recurrent Multifocal Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PamidronateapprovedPhase 24340391-99-94674
Synonyms:
(3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID
(3-Amino-1-hydroxypropylidene)bisphosphonic acid
(3-Amino-1-hydroxypropylidene)diphosphonic acid
(3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
(3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
(3-amino-1-hydroxypropylidene)-1,1-biphosphonate
(3-amino-1-hydroxypropylidene)-1,1-bisphosphonate
1-hydroxy-3-aminopropane-1,1-diphosphonic acid
3-Amino-1-hydroxypropylidene-1,1-diphosphonate
40391-99-9
57248-88-1
57248-88-1 (di-hydrochloride salt)
AC1L1IP4
AHPrBP
AKOS003599275
APD
Acide pamidronique
Acide pamidronique [INN-French]
Acido pamidronico
Acido pamidronico [INN-Spanish]
Acidum pamidronicum
Acidum pamidronicum [INN-Latin]
Amidronate
Aminomux
Aredia
BIDD:GT0538
Bisphosphonate 6
C019248
C07395
C3H11NO7P2
 
CHEMBL834
CID4674
ChemDiv1_025240
D07281
DB00282
EINECS 254-905-2
HMS2090C13
HMS658L06
HSCI1_000312
I14-2407
LS-174826
MolPort-002-131-054
NCGC00159433-02
NCGC00159433-03
Novartis brand of pamidronate disodium salt
PAMIDRONATE DISODIUM
PAMIDRONIC ACID
Pamidronate Disodium
Pamidronic acid
Pamidronic acid (INN)
Pamidronic acid [INN:BAN]
Ribodroat
Ribodroat (TN)
STOCK1N-12562
UNII-OYY3447OMC
amino-1-hydroxypropane-1,1-diphosphonate
aminohydroxypropylidene diphosphonate
aminopropanehydroxydiphosphonate
pamidronate
pamidronate calcium
pamidronate monosodium

Interventional clinical trials:

idNameStatusNCT IDPhase
1Chronic Non-bacterial Osteomyelitis Treated With PamidronateRecruitingNCT02594878Phase 2

Search NIH Clinical Center for Chronic Recurrent Multifocal Osteomyelitis

Genetic Tests for Chronic Recurrent Multifocal Osteomyelitis

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Anatomical Context for Chronic Recurrent Multifocal Osteomyelitis

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MalaCards organs/tissues related to Chronic Recurrent Multifocal Osteomyelitis:

33
Bone, Skin, Breast, Brain, Liver, Prostate, T cells

Animal Models for Chronic Recurrent Multifocal Osteomyelitis or affiliated genes

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MGI Mouse Phenotypes related to Chronic Recurrent Multifocal Osteomyelitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0ALPL, CASP1, IL1B, LPIN2, PYCARD

Publications for Chronic Recurrent Multifocal Osteomyelitis

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Articles related to Chronic Recurrent Multifocal Osteomyelitis:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Chronic recurrent multifocal osteomyelitis with isolated spinal involvement. (27156159)
2016
2
Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO). (27000045)
2016
3
Parotid swelling and chronic recurrent multifocal osteomyelitis of mandible in children. (25468462)
2015
4
Chronic recurrent multifocal osteomyelitis and inflammatory bowel disease. (25493348)
2015
5
GALNT3 gene mutation-associated chronic recurrent multifocal osteomyelitis and familial hyperphosphatemic familial tumoral calcinosis. (25351881)
2014
6
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. (22961119)
2013
7
A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field. (24070048)
2013
8
Diagnostic difficulties: chronic recurrent multifocal osteomyelitis and lymphoma. One or two diseases? (22610142)
2013
9
Chronic recurrent multifocal osteomyelitis in a 13 year old female athlete: a case report. (24302781)
2013
10
Chronic recurrent multifocal osteomyelitis and deficiency of interleukin-1-receptor antagonist. (23241992)
2013
11
Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. (22359228)
2012
12
Normophosphatemic type tumoral calcinosis associated with chronic recurrent multifocal osteomyelitis: a case report. (21610312)
2011
13
Chronic recurrent multifocal osteomyelitis: a case report. (22946018)
2011
14
Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis. (21459961)
2011
15
Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate. (20339868)
2010
16
Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia. (19335222)
2009
17
Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. (19567645)
2009
18
Chronic recurrent multifocal osteomyelitis of the first metatarsal bone: a case report. (19398809)
2009
19
Bisphosphonate treatment in chronic recurrent multifocal osteomyelitis. (18346517)
2008
20
Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature. (17912555)
2008
21
Chronic recurrent multifocal osteomyelitis. (18061969)
2007
22
Chronic recurrent multifocal osteomyelitis is a differential of childhood limp. (16371374)
2006
23
Chronic recurrent multifocal osteomyelitis of the spine and mandible: case report and review of the literature. (15060273)
2004
24
Residents' corner. Answer to case of the month #89. Chronic recurrent multifocal osteomyelitis as a presentation of SAPHO syndrome. (12866248)
2003
25
Chronic recurrent multifocal osteomyelitis: review of orthopaedic complications at maturity. (12131448)
2002
26
Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. (12183714)
2002
27
The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review. (11795677)
2001
28
Chronic recurrent multifocal osteomyelitis with Crohn's disease exacerbation and vasculitis after granulocyte colony-stimulating factor therapy. (19078487)
2000
29
Chronic recurrent multifocal osteomyelitis associated with ulcerative colitis: a case report. (11051168)
2000
30
Chronic recurrent multifocal osteomyelitis showing marked improvement with corticosteroid treatment. (10813311)
2000
31
Chronic recurrent multifocal osteomyelitis in children: diagnostic value of histopathology and microbial testing. (9923928)
1999
32
Chronic recurrent multifocal osteomyelitis--report of eight patients. (9880747)
1998
33
Chronic recurrent multifocal osteomyelitis involving both jaws: report of a case including magnetic resonance correlation. (9117765)
1997
34
Chronic recurrent multifocal osteomyelitis: an evolving clinical and radiological spectrum. (8737997)
1996
35
Chronic recurrent multifocal osteomyelitis (C.R.M.O.). A case report and review of literature. (8933140)
1996
36
Effective treatment with interferon-alpha in chronic recurrent multifocal osteomyelitis. (8564704)
1995
37
Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. (8034808)
1994
38
Case report: chronic recurrent multifocal osteomyelitis with magnetic resonance imaging. (8124893)
1994
39
Chronic recurrent multifocal osteomyelitis. (8451074)
1993
40
Chronic recurrent multifocal osteomyelitis: report of a case. (1554846)
1992
41
Chronic recurrent multifocal osteomyelitis in adult women. (1513515)
1992
42
Binding of bone sialoprotein to Staphylococcus epidermidis isolated from a patient with chronic recurrent multifocal osteomyelitis. (2319176)
1990
43
Chronic recurrent multifocal osteomyelitis. Association with vertebra plana. (2643605)
1989
44
Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings. (2809904)
1989
45
Physeal involvement in chronic recurrent multifocal osteomyelitis. (2602021)
1989
46
Chronic recurrent multifocal osteomyelitis in children. A roentgenologic and scintigraphic investigation. (3166878)
1988
47
Pustulotic arthroosteitis and chronic recurrent multifocal osteomyelitis in children. Report of three cases. (2965242)
1988
48
Chronic recurrent multifocal osteomyelitis and psoriasis--a report of a new association and review of related disorders. (2976529)
1988
49
Chronic recurrent multifocal osteomyelitis. A case report. (6480641)
1984
50
Pustulosis palmoplantaris and its relation to chronic recurrent multifocal osteomyelitis. (478042)
1979

Variations for Chronic Recurrent Multifocal Osteomyelitis

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Expression for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Search GEO for disease gene expression data for Chronic Recurrent Multifocal Osteomyelitis.

Pathways for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Pathways related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.5CASP1, IL1B
2
Show member pathways
9.5CASP1, IL1B
39.5CASP1, IL1B
4
Show member pathways
9.5CASP1, IL1B
5
Show member pathways
8.9CASP1, IL1B, PYCARD
6
Show member pathways
8.9CASP1, IL1B, PYCARD
7
Show member pathways
8.9CASP1, IL1B, PYCARD
88.9CASP1, IL1B, PYCARD
9
Show member pathways
8.9CASP1, IL1B, PYCARD
108.9CASP1, IL1B, PYCARD
11
Show member pathways
8.9CASP1, IL1B, PYCARD

GO Terms for genes affiliated with Chronic Recurrent Multifocal Osteomyelitis

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Biological processes related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:003261110.1CASP1, IL1B
2response to ATPGO:003319810.0CASP1, IL1B
3response to glucocorticoidGO:005138410.0ALPL, IL1B
4positive regulation of interleukin-6 secretionGO:20007789.9IL1B, PYCARD
5positive regulation of interleukin-1 beta secretionGO:00507189.8CASP1, PYCARD
6nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:00358729.7CASP1, PYCARD
7cellular response to mechanical stimulusGO:00712609.7CASP1, IL1B
8positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL1B, PYCARD
9positive regulation of interferon-gamma productionGO:00327299.7IL1B, PYCARD
10stimulatory C-type lectin receptor signaling pathwayGO:00022239.7IL1B, PYCARD
11positive regulation of ERK1 and ERK2 cascadeGO:00703749.6IL1B, PYCARD
12positive regulation of interleukin-6 productionGO:00327559.6IL1B, PYCARD
13positive regulation of apoptotic processGO:00430659.5IL1B, PYCARD
14positive regulation of NF-kappaB transcription factor activityGO:00510929.4IL1B, PYCARD
15cellular response to lipopolysaccharideGO:00712229.4IL1B, PYCARD
16response to lipopolysaccharideGO:00324969.1ALPL, CASP1, IL1B

Sources for Chronic Recurrent Multifocal Osteomyelitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet