MCID: CHR048
MIFTS: 41

Chronic Rhinitis

Categories: Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Chronic Rhinitis

MalaCards integrated aliases for Chronic Rhinitis:

Name: Chronic Rhinitis 12 51 14 69
Rhinitis - Chronic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8252
ICD10 32 J31.0
ICD9CM 34 472.0
NCIt 46 C34479
UMLS 69 C0008711

Summaries for Chronic Rhinitis

Disease Ontology : 12 A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

MalaCards based summary : Chronic Rhinitis, also known as rhinitis - chronic, is related to asthma and rhinitis, and has symptoms including catarrh, rhinorrhea and purulent rhinitis. An important gene associated with Chronic Rhinitis is EDN1 (Endothelin 1), and among its related pathways/superpathways are Melatonin metabolism and effects and Endothelin Pathways. The drugs Capsaicin and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Rhinitis

Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Chronic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 asthma 29.2 EDN1 EPX MPO TRPV1
2 rhinitis 10.7
3 nasopharyngitis 10.5
4 pharyngitis 10.5
5 idiopathic edema 10.3 EDN1 MPO
6 eosinophil peroxidase deficiency 10.2 EPX MPO
7 orthostatic intolerance 10.2 ECE1 EDN1
8 collagenous colitis 10.2 EPX MPO
9 proctitis 10.2 EPX MPO
10 vernal conjunctivitis 10.1 EPX MPO
11 urinary system disease 10.0 EDN1 TRPV1
12 intestinal disease 10.0 MPO TRPV1
13 arteries, anomalies of 10.0 EDN1 TRPV1
14 bronchial disease 10.0 EPX TRPV1
15 sinusitis 9.9
16 maxillary sinusitis 9.9 MPO RHNO1
17 chronic maxillary sinusitis 9.9 MPO RHNO1
18 ischemia 9.9 EDN1 MPO TRPV1
19 multiple cranial nerve palsy 9.9 MPO RHNO1
20 leukemia, acute lymphoblastic 9.8 ASNS MPO
21 headache 9.8
22 nasal cavity disease 9.8 RHNO1 TRPV1
23 nose disease 9.8 RHNO1 TRPV1
24 upper respiratory tract disease 9.8 RHNO1 TRPV1
25 precursor t-cell acute lymphoblastic leukemia 9.7 ASNS MPO
26 gastrointestinal system disease 9.7 MPO TRPV1
27 leukemia, chronic lymphocytic 2 9.6
28 hashimoto thyroiditis 9.6
29 ige responsiveness, atopic 9.6
30 leukemia, chronic lymphocytic 9.6
31 migraine with or without aura 1 9.6
32 otitis media 9.6
33 leprosy 3 9.6
34 allergic rhinitis 9.6
35 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.6
36 leukemia 9.6
37 adenoiditis 9.6
38 lymphoma 9.6
39 adenoid hypertrophy 9.6
40 rhinoscleroma 9.6
41 hypothyroidism 9.6
42 laryngitis 9.6
43 sleep disorder 9.6
44 bronchitis 9.6
45 thyroiditis 9.6
46 leukemia, b-cell, chronic 9.6
47 respiratory system disease 9.5 MPO RHNO1 TRPV1

Comorbidity relations with Chronic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Rhinitis:



Diseases related to Chronic Rhinitis

Symptoms & Phenotypes for Chronic Rhinitis

UMLS symptoms related to Chronic Rhinitis:


catarrh, rhinorrhea, purulent rhinitis

GenomeRNAi Phenotypes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

25 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.7 ASNS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.7 MPO
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.7 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.7 EDN1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.7 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.7 MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.7 EDN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.7 ASNS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.7 ASNS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.7 ASNS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.7 ASNS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 ASNS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 EDN1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.7 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.7 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.7 EDN1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.7 ASNS MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.7 ASNS EDN1 MPO
21 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.7 EDN1

Drugs & Therapeutics for Chronic Rhinitis

Drugs for Chronic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2 Dermatologic Agents Phase 4
3 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
4 Antipruritics Phase 4
5 mometasone furoate Phase 4
6 Anti-Allergic Agents Phase 4
7 Anti-Inflammatory Agents Phase 4,Phase 3
8 glucocorticoids Phase 3
9 Respiratory System Agents Phase 3,Phase 2,Phase 1
10 Hormone Antagonists Phase 3
11 Hormones Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
13 Anti-Asthmatic Agents Phase 3,Phase 1
14 Anti-Bacterial Agents Phase 3
15 Antibiotics, Antitubercular Phase 3
16
Beclomethasone Phase 3 4419-39-0 20469
17 Pharmaceutical Solutions Phase 3
18
Ephedrine Approved Phase 2 299-42-3 9294
19
Pseudoephedrine Approved Phase 2 90-82-4 7028
20
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
21 Neurotransmitter Agents Phase 2,Phase 1
22 Autonomic Agents Phase 2,Phase 1
23
Chlorpheniramine Phase 2 113-92-8, 132-22-9 2725
24 Adrenergic Agents Phase 2
25 Adrenergic Agonists Phase 2
26 Adrenergic alpha-Agonists Phase 2
27 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
28 Nasal Decongestants Phase 2
29 Vasoconstrictor Agents Phase 2
30 Expectorants Phase 2
31 Anti-Obesity Agents Phase 2
32 Appetite Depressants Phase 2
33 Ginkgo Nutraceutical Phase 2
34
Nitric Oxide Approved Phase 1 10102-43-9 145068
35 Vasodilator Agents Phase 1
36 Endothelium-Dependent Relaxing Factors Phase 1
37 Protective Agents Phase 1
38 Antioxidants Phase 1
39 Bronchodilator Agents Phase 1
40
Epinephrine Approved, Vet_approved 51-43-4 5816
41
Lidocaine Approved, Vet_approved 137-58-6 3676
42 Racepinephrine Approved 329-65-7
43
Phenylephrine Approved 59-42-7 6041
44
Oxymetazoline Approved, Investigational 1491-59-4 4636
45 Anesthetics
46 Epinephryl borate
47 Mydriatics
48 Pomegranate Nutraceutical

Interventional clinical trials:

(show all 17)

# Name Status NCT ID Phase Drugs
1 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status NCT02288156 Phase 4 Capsaicin;placebo
2 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
3 Study of Asthma and Nasal Steroids Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
4 Surgical Reduction of the Inferior Turbinates for Nasal Obstruction Terminated NCT00737906 Phase 4
5 Impact of Acupuncture on Vasomotor Rhinitis Completed NCT00682162 Phase 3
6 beCLomethasone Efficacy in Acute Rhinosinusitis - CLEAR Study Completed NCT01691677 Phase 3 beclomethasone dipropionate 800 mcg/2 ml suspension for nebulization,one administration b.i.d. for 14 days;placebo 2 ml suspension for nebulization, one administration b.i.d. for 14 days
7 Cleanoze® Irrigation Device With Powder Preparation Versus Conventional Irrigation Method for Chronic Rhinitis Recruiting NCT02763241 Phase 3 Cleanoze®;Saline (Syringe irrigation)
8 Role of Ginkgo Biloba Extract in IUGR Completed NCT02425436 Phase 2 Ginkgo Biloba Extract
9 The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study Recruiting NCT01364467 Phase 2 Placebo;Guaifenesin
10 Evaluation Effects of Nasal Nitric Oxide Measurements Are Associated With Atopy Status in Chronic Nasal Inflammation Completed NCT01295866 Phase 1
11 A Randomized Double Dummy Double Blind Dose Determining Place-bo Controlled Study to Evaluate Efficacy of Investigational Product E-RH-06 at 2 Dose Levels for the Metabolic Management of Chronic or Recurrent, Non-infective Nasal Congestion With-or-without Unknown status NCT01546662
12 A Randomized Study of Temperature-controlled and Bipolar Radiofrequency for Inferior Turbinate Reduction Completed NCT01054521
13 ClariFix Cryoablation Clinical Study Completed NCT02820597
14 Real-life Management and Therapeutic Outcome of Patients With Chronic Rhinitis and Chronic Urticaria in Thailand Recruiting NCT02000648
15 Evaluation of the ClariFix™ Cryotherapy Device in Subjects With Chronic Rhinitis Recruiting NCT03181594
16 The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic Rhinosinusitis Recruiting NCT01564849
17 Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion Terminated NCT00584662 Oxymetazoline Hydrochloride

Search NIH Clinical Center for Chronic Rhinitis

Genetic Tests for Chronic Rhinitis

Anatomical Context for Chronic Rhinitis

MalaCards organs/tissues related to Chronic Rhinitis:

38
Bone, Testes, Skin, B Cells, Thyroid

Publications for Chronic Rhinitis

Articles related to Chronic Rhinitis:

(show top 50) (show all 123)
# Title Authors Year
1
Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and I+-defensins. ( 26831845 )
2016
2
The effectiveness of oxymetazoline plus intranasal steroid in the treatment of chronic rhinitis: A randomised controlled trial. ( 26994623 )
2016
3
Granulocyte-Macrophage Colony-Stimulating Factor Production and Tissue Eosinophilia in Chronic Rhinitis. ( 27746841 )
2016
4
Radiofrequency inferior turbinate reduction improves smell ability of patients with chronic rhinitis and inferior turbinate hypertrophy. ( 24612902 )
2014
5
Combined radiofrequency volumetric tissue reduction and lateral outfracture of hypertrophic inferior turbinate in the treatment of chronic rhinitis: short-term and long-term outcome. ( 24415652 )
2014
6
Increased proportions of CCR4<sup>+</sup> cells among peripheral blood CD4<sup>+</sup> cells and serum levels of allergen-specific IgE antibody in canine chronic rhinitis and bronchitis. ( 25650058 )
2014
7
Correlation between skin-prick testing, individual specific IgE tests, and a multiallergen IgE assay for allergy detection in patients with chronic rhinitis. ( 25198024 )
2014
8
Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. ( 24607046 )
2014
9
Chronic rhinitis in the cat. ( 24268332 )
2014
10
A study of the role of different forms of chronic rhinitis in the development of otitis media with effusion in children affected by adenoid hypertrophy. ( 24113158 )
2013
11
A new therapy (MP29-02) is effective for the long-term treatment of chronic rhinitis. ( 24654314 )
2013
12
Chronic rhinitis and its association with headache frequency and disability in persons with migraine: Results of the American Migraine Prevalence and Prevention (AMPP) Study. ( 24275145 )
2013
13
Bronchial asthma control after argon plasma coagulation turbinectomy in patients with chronic rhinitis. ( 24141470 )
2013
14
Prevalence of chronic rhinitis in Thai patients with obstructive sleep disordered breathing. ( 24163993 )
2013
15
Correlation between skin prick test and MAST-immunoblot results in patients with chronic rhinitis. ( 23517390 )
2013
16
Chronic rhinitis in South Africa: update 2013. ( 23725964 )
2013
17
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. ( 23346908 )
2013
18
The peculiarities of different types of chronic rhinitis in children and adolescents in Kazakhstan. ( 23785676 )
2013
19
Changes in the prevalence of asthma and chronic rhinitis in Valencia, Spain: the ORBA project 1983-2003. ( 24654316 )
2013
20
Smoking and chronic rhinitis: effects of nasal irrigations with sulfurous-arsenical-ferruginous thermal water: A prospective, randomized, double-blind study. ( 22521235 )
2012
21
Should we perform objective assessment of nasal obstruction in children with chronic rhinitis? ( 23093004 )
2012
22
Vitamin D and chronic rhinitis. ( 22193052 )
2012
23
Chronic rhinitis in HTLV-1 carriers: a histopathologic study. ( 22499368 )
2012
24
Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. ( 22920071 )
2012
25
Differences in airway inflammation according to atopic status in patients with chronic rhinitis. ( 23130330 )
2012
26
Improvement of chronic rhinitis under aspirin. ( 22005504 )
2012
27
Chronic rhinitis: a manifestation of leprosy. ( 21938685 )
2011
28
Epidemiological analysis of chronic rhinitis in pediatric patients. ( 22186247 )
2011
29
Quality of life in patients with chronic rhinitis after radiofrequency inferior turbinate reduction. ( 20718172 )
2010
30
Chronic rhinitis due to Streptococcus equi subspecies zooepidemicus in a dog. ( 20675628 )
2010
31
Comparison of serum-specific IgE (ImmunoCAP) and skin-prick test results for 53 inhalant allergens in patients with chronic rhinitis. ( 19772760 )
2009
32
Pharmacokinetic characteristics and safety and tolerability of a reformulated azelastine hydrochloride nasal spray in patients with chronic rhinitis. ( 19220164 )
2009
33
Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. ( 19720248 )
2009
34
Performance of self-reported occupational exposure compared to a job-exposure matrix approach in asthma and chronic rhinitis. ( 18805880 )
2009
35
Chronic rhinitis secondary to the intrusion of a tooth into the nasal cavity of a cat. ( 19749211 )
2009
36
Prevalence of autoimmune thyroid disease in chronic rhinitis. ( 18800326 )
2008
37
Rhinoscleroma in a young adult with chronic rhinitis and dyspnea. ( 18816882 )
2008
38
A correlation of symptomatology with nasal smear eosinophilia in non-infectious chronic rhinitis preliminary report. ( 18072453 )
2007
39
The skin prick test results of 977 patients suffering from chronic rhinitis in Hong Kong. ( 17406040 )
2007
40
Chronic rhinitis with nasal polyposis associated with sodium glutamate intolerance. ( 17536215 )
2007
41
Investigation of olfactory threshold responses in chronic rhinitis subtypes. ( 18219841 )
2007
42
B-cell nasal lymphoma mimicking hyperplastic chronic rhinitis. ( 16815207 )
2006
43
Chronic rhinitis in cats. ( 16711612 )
2006
44
Functional inferior turbinosurgery (FITS) for the treatment of resistant chronic rhinitis. ( 16803714 )
2006
45
Subjective and objective nasal obstruction assessment in children with chronic rhinitis. ( 16154642 )
2006
46
Evaluation of a novel immunotherapy for treatment of chronic rhinitis in cats. ( 16857403 )
2006
47
What do patients with chronic rhinitis do with their disease? ( 15853854 )
2005
48
The role of atopy in Maltese patients with chronic rhinitis. ( 15142070 )
2004
49
Chronic rhinitis: allergic or nonallergic? ( 12613726 )
2003
50
Does recurrent sinusitis lead to a sinusitis remodeling of the upper airways in asthmatic children with chronic rhinitis? ( 12968393 )
2003

Variations for Chronic Rhinitis

Expression for Chronic Rhinitis

Search GEO for disease gene expression data for Chronic Rhinitis.

Pathways for Chronic Rhinitis

Pathways related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 ECE1 EDN1
2 10.15 ECE1 EDN1

GO Terms for Chronic Rhinitis

Cellular components related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Weibel-Palade body GO:0033093 8.62 ECE1 EDN1

Biological processes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.43 EPX MPO
2 response to mechanical stimulus GO:0009612 9.4 ASNS MPO
3 sensory perception of pain GO:0019233 9.37 EDN1 TRPV1
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.32 EDN1 TRPV1
5 response to amino acid GO:0043200 9.26 ASNS EDN1
6 regulation of vasoconstriction GO:0019229 9.16 ECE1 EDN1
7 hydrogen peroxide catabolic process GO:0042744 8.96 EPX MPO
8 regulation of systemic arterial blood pressure by endothelin GO:0003100 8.62 ECE1 EDN1

Molecular functions related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.62 EPX MPO

Sources for Chronic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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