MCID: CHR466
MIFTS: 43

Chronic Thromboembolic Pulmonary Hypertension

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Chronic Thromboembolic Pulmonary Hypertension

MalaCards integrated aliases for Chronic Thromboembolic Pulmonary Hypertension:

Name: Chronic Thromboembolic Pulmonary Hypertension 49 36 69
Cteph 49

Classifications:



External Ids:

KEGG 36 H01622
UMLS 69 C2363973

Summaries for Chronic Thromboembolic Pulmonary Hypertension

NIH Rare Diseases : 49 Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique pulmonary vascular disease caused by chronic block of the major lung arteries. Signs and symptoms commonly include progressive breathing difficulties (dyspnea) on exertion, fatigue, palpitations, loss of consciousness (syncope), or swelling (edema). The disease may appear a few months or many years after the sudden blockage in a lung artery by a blood clot (acute pulmonary embolism). However, up to 60% of patients have no history of acute pulmonary embolism. Some people with this disease may have clotting problems. Research suggests there may be a genetic predisposition leading to abnormal vascular healing after pulmonary embolism in susceptible individuals, but no specific genemutations have been identified in CTEPH. Curative treatment is done with pulmonary endarterectomy (a surgery that removes the blood clots in the lungs), and more recently by pulmonary balloon angioplasty (a procedure that opens up the vessels of the lung and increases blood flow).  Last updated: 10/18/2016

MalaCards based summary : Chronic Thromboembolic Pulmonary Hypertension, also known as cteph, is related to pulmonary hypertension and pulmonary embolism. An important gene associated with Chronic Thromboembolic Pulmonary Hypertension is FGA (Fibrinogen Alpha Chain), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The drugs Adempas and Bosentan have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related phenotype is cardiovascular system.

Related Diseases for Chronic Thromboembolic Pulmonary Hypertension

Diseases related to Chronic Thromboembolic Pulmonary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 pulmonary hypertension 31.4 BMPR2 EDN1 NPPB
2 pulmonary embolism 30.7 CRP NPPB
3 eisenmenger syndrome 29.9 BMPR2 EDN1
4 dysfibrinogenemia 29.8 FGA FGB
5 arteries, anomalies of 29.4 CRP EDN1 NPPB
6 coronary artery anomaly 29.4 CRP EDN1 NPPB
7 heart disease 28.9 BMPR2 CRP EDN1 NPPB
8 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 11.9
9 pulmonary hypertension, primary, 1 10.5
10 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.2
11 thrombosis 10.2
12 angina pectoris 10.2 CRP FGA
13 endotheliitis 10.2
14 cardiogenic shock 10.2 CRP NPPB
15 chronic mountain sickness 10.2 EDN1 NPPB
16 ischemic heart disease 10.1 CRP NPPB
17 idiopathic edema 10.1 EDN1 NPPB
18 systolic heart failure 10.1 CRP NPPB
19 chronic pulmonary heart disease 10.1 BMPR2 EDN1
20 renal hypertension 10.1 EDN1 NPPB
21 pericardial effusion 10.1 CRP NPPB
22 pericarditis 10.1 CRP NPPB
23 heart conduction disease 10.1 CRP NPPB
24 renal tuberculosis 10.1 CRP EDN1
25 sarcoma 10.0
26 antiphospholipid syndrome 10.0
27 aortic valve disease 1 10.0 CRP NPPB
28 apnea, obstructive sleep 10.0 CRP EDN1
29 dysfibrinogenemia, congenital 10.0 FGA FGB
30 aortic valve disease 2 9.9 CRP NPPB
31 portal hypertension 9.9 BMPR2 EDN1
32 afibrinogenemia 9.9 FGA FGB
33 afibrinogenemia, congenital 9.8 FGA FGB
34 pulmonary edema 9.8 CRP EDN1 NPPB
35 urinary system disease 9.8 CRP EDN1
36 sleep apnea 9.8 CRP EDN1 NPPB
37 blood group, i system 9.8
38 cataract 6, multiple types 9.8
39 fibrosis of extraocular muscles, congenital, 1 9.8
40 schistosoma mansoni infection, susceptibility/ 9.8
41 takayasu arteritis 9.8
42 pulmonary arteriovenous fistulas 9.8
43 resting heart rate, variation in 9.8
44 anxiety 9.8
45 hereditary hemorrhagic telangiectasia 9.8
46 sinusitis 9.8
47 thrombocytopenia 9.8
48 arteriovenous malformation 9.8
49 nephrotic syndrome 9.8
50 esophagitis 9.8

Graphical network of the top 20 diseases related to Chronic Thromboembolic Pulmonary Hypertension:



Diseases related to Chronic Thromboembolic Pulmonary Hypertension

Symptoms & Phenotypes for Chronic Thromboembolic Pulmonary Hypertension

MGI Mouse Phenotypes related to Chronic Thromboembolic Pulmonary Hypertension:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 BMPR2 CRP EDN1 FGA FGB

Drugs & Therapeutics for Chronic Thromboembolic Pulmonary Hypertension

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Adempas 17 RIOCIGUAT Bayer Healthcare Pharmaceuticals October 2013

Drugs for Chronic Thromboembolic Pulmonary Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 3,Phase 1,Phase 2 147536-97-8 104865
2
Treprostinil Approved, Investigational Phase 3 81846-19-7 6918140 54786
3 Endothelin Receptor Antagonists Phase 3,Phase 2,Phase 1
4 Antihypertensive Agents Phase 3,Phase 2,Phase 1
5 Calamus Nutraceutical Phase 3
6
Macitentan Approved Phase 2 441798-33-0
7 adrenomedullin Phase 2
8 Respiratory System Agents Phase 2
9 Fluorodeoxyglucose F18 Phase 2,Phase 1
10 Vasodilator Agents Phase 2
11 Peripheral Nervous System Agents Phase 2
12 Anti-Asthmatic Agents Phase 2
13 Endothelin A Receptor Antagonists Phase 2
14 Protective Agents Phase 2
15 Radiopharmaceuticals Phase 2,Phase 1
16 Autonomic Agents Phase 2
17 Bronchodilator Agents Phase 2
18 Deoxyglucose Phase 1, Phase 2
19 Anti-Infective Agents Phase 1, Phase 2
20 Antimetabolites Phase 1, Phase 2
21 Antiviral Agents Phase 1, Phase 2
22
Warfarin Approved 81-81-2 54678486 6691
23
Rivaroxaban Approved 366789-02-8
24
Thrombin Approved, Investigational
25
Iloprost Approved, Investigational 78919-13-8 6443959
26
Tadalafil Approved, Investigational 171596-29-5 110635
27 Immunoglobulins
28 Antibodies
29 Autoantibodies
30 interferons
31
protease inhibitors
32 Serine Proteinase Inhibitors
33 Coagulants
34 Hemostatics
35 HIV Protease Inhibitors
36 Anesthetics
37 Anticoagulants
38 Factor Xa Inhibitors
39 Antithrombin III
40 Antithrombins
41 Tezosentan
42 Sildenafil Citrate 171599-83-0
43 Phosphodiesterase 5 Inhibitors
44 serine Nutraceutical

Interventional clinical trials:

(show top 50) (show all 69)

# Name Status NCT ID Phase Drugs
1 Influence of Respiratory and Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA Unknown status NCT01393327 Phase 3
2 Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension Completed NCT00313222 Phase 3 bosentan
3 Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension Completed NCT01884012 Phase 3
4 Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Completed NCT00319111 Phase 3 bosentan
5 A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH. Completed NCT00855465 Phase 3 Riociguat (Adempas, BAY63-2521);Placebo
6 CTEPH DIAGNOSIS Europe - MRI Recruiting NCT02791282 Phase 3
7 Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH) Active, not recruiting NCT01416636 Phase 3 Treprostinil sodium
8 BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT00910429 Phase 3 Riociguat (Adempas, BAY63-2521)
9 Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension. Terminated NCT01884675 Phase 3 Ambrisentan 5 mg;Placebo
10 A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Terminated NCT01894022 Phase 3 Ambrisentan 5 mg
11 Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Completed NCT02021292 Phase 2 Macitentan;Placebo
12 Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH Completed NCT02094001 Phase 2
13 Effect of Short-term Oxygen During CPET in Pulmonary Hypertension Completed NCT01748474 Phase 2
14 An Open Multiple Dose Titration Study In Patients With Pulmonary Hypertension Completed NCT00454558 Phase 2 Riociguat (Adempas, BAY63-2521)
15 Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension Completed NCT02216279 Phase 2 PulmoBind
16 Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy Recruiting NCT02745106 Phase 2
17 Bosentan in Myocardium Metabolism and Perfusion Measured by 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and Rubidium-82 (82Rb) Positron Emission Tomography/Computed Tomography (PET/CTs) on Pulmonary Arterial Hypertension (PAH) or Chronic Thromboembolic Pulmo Recruiting NCT02970851 Phase 1, Phase 2
18 Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT02060721 Phase 2 Macitentan
19 Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) Not yet recruiting NCT03273257 Phase 2 Riociguat;Placebo
20 Cell Proliferation in Pulmonary Hypertension. FDG-PET Comparison Between Patients and Healthy Subjects Not yet recruiting NCT02886793 Phase 1, Phase 2 fludeoxyglucose
21 Prospective Registry to Evaluate the Effective Incidence of Chronic Thromboembolic Pulmonary Hypertension in Germany Unknown status NCT02660463
22 Latent Pulmonary Hypertension (PH) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH )After Endarterectomy and Influence of Exercise and Respiratory Therapy Unknown status NCT00477724
23 Right Ventricular Resynchronization Therapy Unknown status NCT01163422
24 3D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary Endarterectomy Unknown status NCT02426203
25 Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism Unknown status NCT01672203
26 Epidemiological Study of Chronic Thromboembolic Pulmonary Hypertension in China Unknown status NCT01717092
27 Gene Mutations in Secondary Pulmonary Hypertension Unknown status NCT00348803
28 Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging Completed NCT02114047
29 A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice Completed NCT02545465 Riociguat (Adempas, BAY63-2521)
30 Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients Completed NCT00747045
31 Study on the Clinical Course Of Pulmonary Embolism Completed NCT01781858
32 Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension Completed NCT02536534
33 Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic Hypertension Completed NCT00657722
34 Smoking: a Risk Factor for Pulmonary Arterial Hypertension? Completed NCT01484899
35 RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter Defibrillators Completed NCT02111980
36 Auto-immunity and Pulmonary Arterial Hypertension Completed NCT01208792
37 Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension Recruiting NCT02634203 Riociguat
38 Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region Recruiting NCT03349164
39 Sleep Disorder Breathing in Chronic Thromboembolic Pulmonary Hypertension Recruiting NCT03074539 Riociguat
40 Determinants of Right Heart Remodeling in Patients With CTEPH or PAH Recruiting NCT03205085
41 Assessment of Blood Coagulation Disorders in Patients With Pulmonary Hypertension Recruiting NCT03195543
42 Lung Perfusion Measured With Dual-Energy CT in Patients With Chronic Thromboembolic Pulmonary Hypertension: Comparative Study With Right Heart Catheterization and V/Q Recruiting NCT03450304
43 Registry for Pulmonary Hypertension in China Recruiting NCT01417338
44 U.S. CTEPH Registry Recruiting NCT02429284
45 Balloon Pulmonary Angioplasty in Non-operable CTEPH Patients Recruiting NCT02964390
46 Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH ) Recruiting NCT02117791 Riociguat (ADEMPAS, BAY63-2521)
47 The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging Recruiting NCT03199131
48 Long Term Outcomes of Venous Thromboembolism Recruiting NCT02268630
49 Early Non-invasive Detection of CTEPH After Pulmonary Embolism Recruiting NCT02555137
50 Effect of Exercise Training in Patients With Pulmonary Hypertension Recruiting NCT02558582

Search NIH Clinical Center for Chronic Thromboembolic Pulmonary Hypertension

Genetic Tests for Chronic Thromboembolic Pulmonary Hypertension

Anatomical Context for Chronic Thromboembolic Pulmonary Hypertension

MalaCards organs/tissues related to Chronic Thromboembolic Pulmonary Hypertension:

38
Lung, Heart, Endothelial, Brain, Testes, Neutrophil, Monocytes

Publications for Chronic Thromboembolic Pulmonary Hypertension

Articles related to Chronic Thromboembolic Pulmonary Hypertension:

(show top 50) (show all 537)
# Title Authors Year
1
Adherence and medication belief in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension: A nationwide population-based cohort survey. ( 29356440 )
2018
2
Chronic Thromboembolic Pulmonary Hypertension. ( 29446688 )
2018
3
Epidemiology and risk factors for chronic thromboembolic pulmonary hypertension. ( 29338883 )
2018
4
Coping, social support and information in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension: A 2-year retrospective cohort study. ( 29326818 )
2018
5
Incidence and characteristics of chronic thromboembolic pulmonary hypertension in Germany. ( 29450722 )
2018
6
Bosentan Therapy for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: A Systemic Review and Meta-Analysis. ( 29393580 )
2018
7
Severe Compression of the Left Main Coronary Artery in a Patient with Chronic Thromboembolic Pulmonary Hypertension. ( 29321385 )
2018
8
Sex-specific cardiopulmonary exercise testing indices to estimate the severity of inoperable chronic thromboembolic pulmonary hypertension. ( 29416329 )
2018
9
Impact of Balloon Pulmonary Angioplasty on Hemodynamics and Clinical Outcomes in Patients with Chronic Thromboembolic Pulmonary Hypertension: the Initial Korean Experience. ( 29318791 )
2018
10
Chronic thromboembolic pulmonary hypertension and homocysteinaemia. ( 29294117 )
2018
11
Balloon Pulmonary Angioplasty Relieves Hemodynamic Stress towards Untreated-Side Pulmonary Vasculature and Ameliorates Its Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension. ( 29360065 )
2018
12
Balloon pulmonary angioplasty is effective for treating peripheral-type chronic thromboembolic pulmonary hypertension in elderly patients. ( 29278287 )
2017
13
N-terminal pro-B-type natriuretic peptide for monitoring after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension. ( 29329761 )
2017
14
Combination therapy with riociquat and inhaled treprostinil in inoperable and progressive chronic thromboembolic pulmonary hypertension. ( 27942445 )
2017
15
Reply: Tidal Carbon Dioxide as a Prognostic Feature in Inoperable Chronic Thromboembolic Pulmonary Hypertension. ( 28806530 )
2017
16
The changing landscape of chronic thromboembolic pulmonary hypertension management. ( 29263176 )
2017
17
Microarray Analysis and Detection of MicroRNAs Associated with Chronic Thromboembolic Pulmonary Hypertension. ( 28904974 )
2017
18
Modern diagnosis of chronic thromboembolic pulmonary hypertension. ( 28918335 )
2017
19
To screen or not to screen for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. ( 28073030 )
2017
20
A Review of Clinical Trial Endpoints of Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension and How They Relate to Patient Outcomes in the United States. ( 28025931 )
2017
21
Treatment Effect of Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension Quantified by Automatic Comparative Imaging in Computed Tomography Pulmonary Angiography. ( 29278545 )
2017
22
Pulmonary Artery Diameter Predicts Lung Injury After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28701673 )
2017
23
Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target. ( 28289017 )
2017
24
Epidemiology and management of chronic thromboembolic pulmonary hypertension: Experience from two expert centers. ( 28528258 )
2017
25
Hereditary hyperhomocysteinemia associated with nephrotic syndrome complicated by artery thrombosis and chronic thromboembolic pulmonary hypertension: A case report. ( 29424201 )
2017
26
Early Development of Right Ventricular Ischemic Lesions in a Novel Large Animal Model of Acute Right Heart Failure in Chronic Thromboembolic Pulmonary Hypertension. ( 28801076 )
2017
27
An Update on the Management of Chronic Thromboembolic Pulmonary Hypertension. ( 27989311 )
2017
28
Stepwise optimisation of balloon pulmonary angioplasty in a patient with severe non-operable chronic thromboembolic pulmonary hypertension. ( 28691912 )
2017
29
Depressive Status in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28529263 )
2017
30
The effective systematic heparin pre-treatment on thrombus formation on pulmonary artery catheter tips during pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a randomized, double-blind study. ( 28875371 )
2017
31
The Challenge in Diagnosis and Current Treatment of Chronic Thromboembolic Pulmonary Hypertension. ( 28790235 )
2017
32
Plexiform Vasculopathy in Chronic Thromboembolic Pulmonary Hypertension. ( 28892403 )
2017
33
Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. ( 28750932 )
2017
34
Novel Predictor of Lung Injury After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28717116 )
2017
35
Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study. ( 28919201 )
2017
36
Imaging in Chronic Thromboembolic Pulmonary Hypertension. ( 28060193 )
2017
37
Individual dose adjustment of riociguat in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. ( 28732819 )
2017
38
Transition of Intravenous Treprostinil to Oral Therapy in a Patient with Functional Class IV Chronic Thromboembolic Pulmonary Hypertension. ( 28513869 )
2017
39
A chronic thromboembolic pulmonary hypertension catch-22 situation: inferior vena caval filter plays a pivotal role in an unlikely situation. ( 28523175 )
2017
40
Tidal Carbon Dioxide as a Prognostic Feature in Inoperable Chronic Thromboembolic Pulmonary Hypertension. ( 28806531 )
2017
41
Systolic Anterior Motion of the Mitral Valve During Pulmonary Endarterectomy in a Patient with Chronic Thromboembolic Pulmonary Hypertension: A Case Report. ( 29398378 )
2017
42
Associations of Exercise Tolerance With Hemodynamic Parameters for Pulmonary Arterial Hypertension and for Chronic Thromboembolic Pulmonary Hypertension. ( 28671932 )
2017
43
Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension. ( 28682884 )
2017
44
Chronic Thromboembolic Pulmonary Hypertension: Epidemiology, Diagnosis, and Management. ( 28832374 )
2017
45
Riociguat in patients with chronic thromboembolic pulmonary hypertension: results from an early access study. ( 29282032 )
2017
46
Extensive revascularization by balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension beyond hemodynamic normalization. ( 28804055 )
2017
47
Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: Correlation with perfusion SPECT/CT. ( 28526539 )
2017
48
Riociguat for patients with chronic thromboembolic pulmonary hypertension: Usefulness of transitioning from phosphodiesterase type 5 inhibitor. ( 28705306 )
2017
49
Mosaic attenuation pattern in non-contrast computed tomography for the assessment of pulmonary perfusion in chronic thromboembolic pulmonary hypertension. ( 28942885 )
2017
50
Heart Rate and Oxygen Saturation Change Patterns During 6-min Walk Test in Subjects With Chronic Thromboembolic Pulmonary Hypertension. ( 29279364 )
2017

Variations for Chronic Thromboembolic Pulmonary Hypertension

Expression for Chronic Thromboembolic Pulmonary Hypertension

Search GEO for disease gene expression data for Chronic Thromboembolic Pulmonary Hypertension.

Pathways for Chronic Thromboembolic Pulmonary Hypertension

GO Terms for Chronic Thromboembolic Pulmonary Hypertension

Cellular components related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 CPB2 CRP EDN1 FGA FGB NPPB
2 platelet alpha granule lumen GO:0031093 9.37 FGA FGB
3 extracellular vesicle GO:1903561 9.32 FGA FGB
4 platelet alpha granule GO:0031091 9.26 FGA FGB
5 extracellular space GO:0005615 9.17 BMPR2 CPB2 CRP EDN1 FGA FGB
6 fibrinogen complex GO:0005577 8.96 FGA FGB

Biological processes related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.71 CPB2 FGA FGB
2 cellular response to interleukin-1 GO:0071347 9.63 EDN1 FGB
3 regulation of blood pressure GO:0008217 9.62 EDN1 NPPB
4 response to calcium ion GO:0051592 9.62 FGA FGB
5 positive regulation of endothelial cell migration GO:0010595 9.61 BMPR2 EDN1
6 toll-like receptor signaling pathway GO:0002224 9.61 FGA FGB
7 platelet aggregation GO:0070527 9.6 FGA FGB
8 positive regulation of protein secretion GO:0050714 9.59 FGA FGB
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 FGA FGB
10 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.58 FGA FGB
11 positive regulation of vasoconstriction GO:0045907 9.57 FGA FGB
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.56 FGA FGB
13 positive regulation of exocytosis GO:0045921 9.55 FGA FGB
14 cellular protein complex assembly GO:0043623 9.52 FGA FGB
15 regulation of blood vessel size GO:0050880 9.51 EDN1 NPPB
16 positive regulation of renal sodium excretion GO:0035815 9.49 EDN1 NPPB
17 positive regulation of urine volume GO:0035810 9.48 EDN1 NPPB
18 protein polymerization GO:0051258 9.46 FGA FGB
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.43 FGA FGB
20 plasminogen activation GO:0031639 9.4 FGA FGB
21 body fluid secretion GO:0007589 9.37 EDN1 NPPB
22 positive regulation of peptide hormone secretion GO:0090277 9.32 FGA FGB
23 induction of bacterial agglutination GO:0043152 9.26 FGA FGB
24 blood coagulation, fibrin clot formation GO:0072378 9.16 FGA FGB
25 hemostasis GO:0007599 9.13 CPB2 FGA FGB
26 fibrinolysis GO:0042730 8.8 CPB2 FGA FGB

Molecular functions related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 9.16 FGA FGB
2 cell adhesion molecule binding GO:0050839 8.96 FGA FGB
3 receptor binding GO:0005102 8.92 EDN1 FGA FGB NPPB

Sources for Chronic Thromboembolic Pulmonary Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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