MCID: CHR466
MIFTS: 35

Chronic Thromboembolic Pulmonary Hypertension malady

Respiratory diseases, Rare diseases, Blood diseases categories

Aliases & Classifications for Chronic Thromboembolic Pulmonary Hypertension

About this section
Sources:
51Orphanet, 65UMLS, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Chronic Thromboembolic Pulmonary Hypertension:

Name: Chronic Thromboembolic Pulmonary Hypertension 51 65
 
Cteph 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
chronic thromboembolic pulmonary hypertension:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult


External Ids:

Orphanet51 70591
UMLS via Orphanet66 C2363973

Summaries for Chronic Thromboembolic Pulmonary Hypertension

About this section
MalaCards based summary: Chronic Thromboembolic Pulmonary Hypertension, also known as cteph, is related to hypertension, essential and vascular hemostatic disease. An important gene associated with Chronic Thromboembolic Pulmonary Hypertension is NPPB (Natriuretic Peptide B), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and MicroRNAs in cardiomyocyte hypertrophy. Affiliated tissues include lung, heart and endothelial, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Related Diseases for Chronic Thromboembolic Pulmonary Hypertension

About this section

Diseases related to Chronic Thromboembolic Pulmonary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension, essential30.4BMPR2, CRP, EDN1, NPPB, PTGIS
2vascular hemostatic disease29.2CRP, EDN1, FGA, PTGIS
3pulmonary hypertension11.6
4pulmonary embolism10.9
5pulmonary hypertension, primary, 310.6
6chronic pulmonary heart disease10.6
7endotheliitis10.6
8coronary heart disease 610.6
9pulmonary hypertension, primary, 210.5
10congenital heart disease10.5
11vascular disease10.5
12peripheral vascular disease10.5
13antiphospholipid syndrome10.5
14respiratory system disease10.5
15sarcoma10.5
16vein disease10.5
17vascular malformation10.5
18trichohepatoenteric syndrome 110.4
19coronary heart disease 910.4
20thrombophilia due to thrombin defect10.4
21alexander disease10.4
22mycobacterium avium complex disease10.4
23newcastle disease10.4
24pulmonary tuberculosis10.4
25oral tuberculosis10.4
26peripheral artery disease10.4
27coats disease10.4
28tuberculosis10.4
29heritable pulmonary arterial hypertension10.4
30dysfibrinogenemia10.4
31dawson disease10.4
32idiopathic and/or familial pulmonary arterial hypertension10.4
33asthma10.2
34anemia, sideroblastic, pyridoxine-refractory, autosomal recessive10.2
35coronary heart disease 510.2
36hypertension, diastolic10.2
37trichohepatoenteric syndrome 210.2
38asthma 210.2
39coronary heart disease 810.2
40asthma 110.2
41kawasaki disease10.2
42hereditary hemorrhagic telangiectasia10.2
43sinusitis10.2
44thrombocytopenia10.2
45spondylosis10.2
46post-thrombotic syndrome10.2
47homocystinuria10.2
48intrinsic asthma10.2
49systolic heart failure10.2
50lipoid nephrosis10.2

Graphical network of the top 20 diseases related to Chronic Thromboembolic Pulmonary Hypertension:



Diseases related to chronic thromboembolic pulmonary hypertension

Symptoms for Chronic Thromboembolic Pulmonary Hypertension

About this section

Drugs & Therapeutics for Chronic Thromboembolic Pulmonary Hypertension

About this section

Drugs for Chronic Thromboembolic Pulmonary Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bosentanapproved, investigationalPhase 399147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
2
Treprostinilapproved, investigationalPhase 37181846-19-754786, 6918140
Synonyms:
((1R,2R,3aS,9aS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate
(1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-hexahydro-2-hydroxy- 1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl] oxy]acetic acid
({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetic acid
15 AU81
15AU81
2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid
2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid
289480-64-4 (Sodium salt)
81846-19-7
AC1L1HPX
AC1OCF2J
CHEBI:50861
CID11246284
CID54786
CID6918140
CID9800580
D06213
DB00374
L001079
LRX 15
 
LS-177654
LS-187014
LS-187645
Orenitram
Remodulin
Remodulin (TN)
Treprostinil
Treprostinil (USAN/INN)
Treprostinil [USAN:INN]
Treprostinil sodium
Treprostinilo
Treprostinilum
Tyvaso
U 62840
U-62,840
UNII-RUM6K67ESG
UT-15
Uniprost
Viveta
[[(1R,2R,3aS,9aS)-2-Hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphtalen-5-yl]oxy]acetic acid
treprostinilo
treprostinilum
3CalamusNutraceuticalPhase 3312
4adrenomedullinPhase 211
5Gadobenic acidPhase 282
6Gadolinium DTPAPhase 282
7Fluorodeoxyglucose F18Phase 2340
8
Rivaroxabanapproved190366789-02-8
Synonyms:
BAY 59-7939
 
BAY59-7939
Xarelto
9
Warfarinapproved39181-81-26691, 54678486
Synonyms:
(-)-Warfarin
(S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone
(S)-Warfarin
(phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarin
(phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine
1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
200 Coumarin
200 coumarin
3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
3-(Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin
3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin
4-Hydroxy-3- (3-oxo-1-fenyl-butyl) cumarine
4-Hydroxy-3- (3-oxo-1-phenyl-butyl)-cumarin
4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine
4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
4-Idrossi-3- (3-oxo-)-fenil-butil)-cumarine
4-Idrossi-3-(3-oxo-)-fenil-butil)-cumarine
4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine
45706_FLUKA
45706_RIEDEL
4oh-coumarin deriv.
5543-56-6
5543-57-7
81-81-2
A2250_FLUKA
A2250_SIGMA
AC-15978
AC1L1N37
AC1Q6AN3
AR-1E2310
Arab Rat Death
Arab rat death
Arab rat deth
Athrombin
Athrombin-K
Athrombin-k
Athrombine-K
Athrombine-k
BRD-A24514565-001-02-2
BRD-A24514565-236-01-6
BRN 1293536
BSPBio_002026
Bio-0586
Brumolin
C01541
C19H16O4
CBDivE_002127
CBDivE_013236
CBKinase1_000192
CBKinase1_012592
CHEBI:10033
CHEMBL1464
CID6691
CO-Rax
Caswell No. 903
Choice
Choice (TN)
Co-Rax
Co-rax
Compound 42
Coumadin
Coumadin Tabs
Coumafen
Coumafene
Coumafene [French]
Coumaphen
Coumaphene
Coumarins
Coumefene
Cov-R-Tox
Cov-R-tox
D-Con
D08682
DB00682
DL-3-(alpha-acetonylbenzyl)-4-hydroxycoumarin
Dethmor
Dethnel
Dicusat E
Dicusat e
DivK1c_000444
EINECS 201-377-6
EINECS 226-907-3
EPA Pesticide Chemical Code 086002
Eastern states duocide
Fasco fascrat powder
Frass-Ratron
Frass-ratron
HMS1921K07
HMS2092C20
HMS501G06
HSDB 1786
I14-0958
IDI1_000444
Jantoven
KBio1_000444
KBio2_000674
KBio2_003242
KBio2_005810
KBio3_001526
KBioGR_000901
KBioSS_000674
Killgerm sewarin p
Kumader
Kumadu
Kumatox
Kypfarin
LS-55083
Latka 42
Latka 42 [Czech]
Liqua-tox
MLS001304042
Maag Rattentod Cum
Maag rattentod cum
Mar-Frin
Mar-frin
Marevan
Martin'S mar-frin
Martin's mar-frin
 
Maveran
MolPort-001-787-822
Mouse pak
NCGC00094810-01
NCGC00094810-02
NCGC00159398-03
NCGC00178855-01
NINDS_000444
NSC 59813
NSC59813
PS104_SUPELCO
Panwarfin
Place-Pax
Place-pax
Prothromadin
RAX
RCR grey squirrel killer concentrate
RCRA waste no. P001
Rat & mice bait
Rat and mice bait
Rat-B-gon
Rat-Gard
Rat-Kill
Rat-Mix
Rat-O-cide #2
Rat-O-cide no. 2
Rat-Ola
Rat-Trol
Rat-a-way
Rat-alpha-way
Rat-b-gon
Rat-beta-gon
Rat-gard
Rat-kill
Rat-mix
Rat-o-cide #2
Rat-ola
Rat-trol
Ratorex
Ratox
Ratoxin
Ratron
Ratron G
Ratron g
Rats-no-more
Ratten-Koederrohr
Ratten-koederrohr
Rattenstreupulver Neu Schacht
Rattenstreupulver neu schacht
Rattenstreupulver new schacht
Rattentraenke
Rattunal
Rcra waste number P001
Ro-Deth
Ro-deth
Rodafarin
Rodafarin C
Rodafarin c
Rodex
Rodex blox
Rosex
Rough & ready mouse mix
Rough and ready mouse mix
SMP1_000316
SMR000718754
SPBio_000870
SPECTRUM1500613
STK364490
Sakarat
Sewarin
Sofarin
Solfarin
Sorexa Plus
Sorexa plus
Spectrum2_000935
Spectrum3_000583
Spectrum4_000381
Spectrum5_001751
Spectrum_000194
Spray-trol brand roden-trol
Temus W
Temus w
Tintorane
Tox-Hid
Tox-hid
Twin light rat away
UNII-5Q7ZVV76EI
Vampirinip II
Vampirinip III
Vampirinip iii
W.A.R.F. 42
WARF compound 42
WLN: T66 BOVJ DYR&1V1 EQ
Waran
Warf 10
Warf 42
Warfarat
Warfarin (INN)
Warfarin (and salts of)
Warfarin Plus
Warfarin Q
Warfarin Sodium
Warfarin [BSI:ISO]
Warfarin [INN:BAN]
Warfarin plus
Warfarin plus [discontinued]
Warfarin sodium
Warfarin titrated to an INR of 2.5-3.0
Warfarin(R)
Warfarina
Warfarina [INN-Spanish]
Warfarine
Warfarine [INN-French]
Warfarine [ISO-French]
Warfarinum
Warfarinum [INN-Latin]
Warficide
Warfilone
Zoocoumarin
Zoocoumarin [Netherlands and USSR]
Zoocoumarin [Russian]
delta-Con
nchembio.307-comp19
rac-Warfarin
warfarin
10
Tadalafilapproved, investigational137171596-29-5110635
Synonyms:
(6R,12AR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
171596-29-5
1xoz
6-BENZO[1,3]dioxol-5-yl-2-methyl-2,3,6,7,12,12a-hexahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
AC1L380B
ADCIRCA
Acdirca
Adcirca
C429886
CHEBI:41488
CHEMBL779
CID110635
CPD000466321
Cialis
Cialis (TN)
Cialis, GF 196960, IC 351, ICOS 351, Tadalafil
D02008
DB00820
FT-0080116
GF 196960
GF-196960
 
HMS2051N17
HSDB 7303
IC 351
IC-351
ICOS 351
Ic351
KS-1117
LS-186558
LS-187015
LS-187770
Lilly brand of tadalafil
MLS000759426
MLS001165782
MLS001195644
MLS001424132
MolPort-002-885-864
S1512_Selleck
SAM001246586
SMR000466321
Tadalafil
Tadalafil (JAN/USAN/INN)
Tadalafil [USAN]
Tadanafil
UNII-742SXX0ICT
ZINC03993855
11
Sildenafilapproved, investigational296139755-83-25212
Synonyms:
1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-D)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
139755-83-2
171599-83-0 (citrate)
1udt
1xos
2h42
5-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (Sildenafil or Viagra)
5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one(Sildenafil)
5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
5-{2-(ethyloxy)-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
AC-938
AC1L1JUI
Ambap139755-83-2
Aphrodil
Aphrodil (TN)
BAS 04213629
BIDD:GT0352
BRD-K79759585-001-02-1
BSPBio_003424
C07259
C22H30N6O4S
CHEBI:9139
CHEMBL192
CID5212
Caverta
D08514
DB00203
DivK1c_006894
HMS1684K08
HMS1922B19
HMS2089M12
HMS2093O17
HSDB 7305
 
I06-0023
Jsp002373
KBio1_001838
KBio2_002035
KBio2_004603
KBio2_007171
KBio3_002927
KBioGR_001052
KBioSS_002035
LS-111655
MLS001240224
MLS001304737
MolPort-001-995-394
MolPort-002-885-861
NCGC00095099-01
NCGC00095099-02
NCGC00159496-02
Revatio
SMR000752512
SPBio_001775
SPECTRUM1504099
Sildenafil
Sildenafil (INN)
Sildenafil Citrate
Sildenafil Viagra
Sildenafil [INN:BAN]
Sildenafil citrate
SpecPlus_000798
Spectrum2_001648
Spectrum3_001892
Spectrum4_000586
Spectrum5_001508
Spectrum_001555
UK-92,480-10
UK-92480
UNII-3M7OB98Y7H
VIA
Viagra
sildenafil
12
Iloprostapproved, investigational7378919-13-86443959
Synonyms:
(16R,S)-Methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandin I(sub 2)
(5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
(5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
(5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
(5Z)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(E,3R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
(E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric acid
(E)-5-(3aS,4R,5R,6aS)-5-Hydroxy-4((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-inyl)perhydropentalen-2-yliden)valeriansaeure
73873-87-7
78919-13-8
AC1NSK5T
AC1O5JIJ
AC1O5JP3
AC1Q1J28
ACT-213105
C22H32O4
CHEMBL138694
CHEMBL236025
CHEMBL494
CID10937300
CID11639089
CID5311181
CID6435293
CID6435378
CID9885245
 
CID9975807
Ciloprost
D02721
E-1030
Endoprost
HMS2090A19
ILOPROST
Ilomedin
Ilomedine
Iloprost
Iloprost (INN)
Iloprost [BAN:INN]
Iloprostum
Iloprostum [Latin]
L000996
LS-101845
NCGC00181784-01
PDSP2_001536
SH-401
UNII-JED5K35YGL
Ventavis
Ventavis (TN)
ZK 36374
ZK-36374
ZK-363775
[3H]-Iloprost
13Phosphodiesterase 5 Inhibitors518
14Tezosentan61

Interventional clinical trials:

(show all 49)
idNameStatusNCT IDPhase
1Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension.CompletedNCT01884675Phase 3
2Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary HypertensionCompletedNCT00313222Phase 3
3Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)CompletedNCT00319111Phase 3
4A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)CompletedNCT01894022Phase 3
5A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH.CompletedNCT00855465Phase 3
6Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH)RecruitingNCT01416636Phase 3
7Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary HypertensionRecruitingNCT01884012Phase 3
8Influence of Respiratory and Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEARecruitingNCT01393327Phase 3
9BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary HypertensionActive, not recruitingNCT00910429Phase 3
10An Open Multiple Dose Titration Study In Patients With Pulmonary HypertensionCompletedNCT00454558Phase 2
11Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary HypertensionCompletedNCT02216279Phase 2
12Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary HypertensionRecruitingNCT02021292Phase 2
13Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary HypertensionRecruitingNCT02060721Phase 2
14Effect of Short-term Oxygen During CPET in Pulmonary HypertensionRecruitingNCT01748474Phase 2
15Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPHRecruitingNCT02094001Phase 2
16Look at Way the Heart Functions in People With Pulmonary Hypertension (PH) Who Have Near Normal Right Ventricle (RV) Function and People With Pulmonary Hypertension Who Have Impaired RV Function. Using Imaging Studies PET Scan and Cardiac MRI.RecruitingNCT01953965Phase 2
17Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) PatientsCompletedNCT00747045
18Study on the Clinical Course Of Pulmonary EmbolismCompletedNCT01781858
19Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic HypertensionCompletedNCT00657722
20Smoking: a Risk Factor for Pulmonary Arterial Hypertension?CompletedNCT01484899
21RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter DefibrillatorsCompletedNCT02111980
22Chronic Thrombo-embolic Pulmonary Hypertension: Classification and Long Term OutcomeRecruitingNCT02565030
23Prospective Registry to Evaluate the Effective Incidence of Chronic Thromboembolic Pulmonary Hypertension in GermanyRecruitingNCT02660463
24Registry for Pulmonary Hypertension in ChinaRecruitingNCT01417338
25Latent Pulmonary Hypertension (PH) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH )After Endarterectomy and Influence of Exercise and Respiratory TherapyRecruitingNCT00477724
26Evaluation of Pulmonary Perfusion Heterogeneity in Patients With Chronic Thromboembolic Pulmonary Hypertension Using Functional PET ImagingRecruitingNCT02114047
27U.S. CTEPH RegistryRecruitingNCT02429284
28A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical PracticeRecruitingNCT02545465
29Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH)RecruitingNCT02117791
30Long Term Outcomes of Venous ThromboembolismRecruitingNCT02268630
31New International CTEPH DatabaseRecruitingNCT02656238
32Electronic Activity Level Monitoring Pilot in Pulmonary HypertensionRecruitingNCT02536534
33Effect of Exercise Training in Patients With Pulmonary HypertensionRecruitingNCT02558582
34Sleep Disordered Breathing in Precapillary Pulmonary Hypertension: Effect of CPAP TreatmentRecruitingNCT02583906
35Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral EmbolismRecruitingNCT01672203
36Epidemiological Study of Chronic Thromboembolic Pulmonary Hypertension in ChinaRecruitingNCT01717092
37Follow-up in Rivaroxaban Patients in Setting of ThromboembolismRecruitingNCT02248610
38Global Anticoagulant Registry in the FIELD- Venous Thromboembolic EventsRecruitingNCT02155491
39Gene Mutations in Secondary Pulmonary HypertensionRecruitingNCT00348803
40Z├╝rich Pulmonary Hypertension Outcome Assessment CohortRecruitingNCT02249806
41EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary HypertensionRecruitingNCT02092818
42VTEval Project - Prospective Cohort Studies to Evaluate and Improve Diagnostics, Management Strategies and Risk Stratification in VTERecruitingNCT02156401
43Auto-immunity and Pulmonary Arterial HypertensionActive, not recruitingNCT01208792
44Right Ventricular Resynchronization TherapyEnrolling by invitationNCT01163422
45Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary HypertensionNot yet recruitingNCT02634203
46A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA CountriesNot yet recruitingNCT02637050
47Early Non-invasive Detection of CTEPH After Pulmonary EmbolismNot yet recruitingNCT02555137
483D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary EndarterectomyNot yet recruitingNCT02426203
49Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)No longer availableNCT01784562

Search NIH Clinical Center for Chronic Thromboembolic Pulmonary Hypertension

Genetic Tests for Chronic Thromboembolic Pulmonary Hypertension

About this section

Anatomical Context for Chronic Thromboembolic Pulmonary Hypertension

About this section

MalaCards organs/tissues related to Chronic Thromboembolic Pulmonary Hypertension:

33
Lung, Heart, Endothelial, Brain, Neutrophil, Monocytes, Smooth muscle

Animal Models for Chronic Thromboembolic Pulmonary Hypertension or affiliated genes

About this section

MGI Mouse Phenotypes related to Chronic Thromboembolic Pulmonary Hypertension:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5BMPR2, CRP, EDN1, FGA, PTGIS
2MP:00053857.0BMPR2, CRP, EDN1, FGA, NPPB, PTGIS

Publications for Chronic Thromboembolic Pulmonary Hypertension

About this section

Articles related to Chronic Thromboembolic Pulmonary Hypertension:

(show top 50)    (show all 442)
idTitleAuthorsYear
1
Noninvasive assessment of pulmonary vascular resistance by echocardiography in chronic thromboembolic pulmonary hypertension. (26344610)
2015
2
Balloon pulmonary angioplasty using contrast agents improves impaired renal function in patients with chronic thromboembolic pulmonary hypertension. (25880583)
2015
3
Recent advances of pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension including Japanese experiences. (24068659)
2014
4
Operability Assessment and Postoperative Outcome in Chronic Thromboembolic Pulmonary Hypertension. (24401572)
2014
5
Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension. (24978044)
2014
6
Dual-energy CT perfusion and angiography in chronic thromboembolic pulmonary hypertension: diagnostic accuracy and concordance with radionuclide scintigraphy. (23982287)
2014
7
Balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension. (23846611)
2013
8
Clinical outcomes of thromboendarterectomy for chronic thromboembolic pulmonary hypertension: 12-year experience. (23423163)
2013
9
Optical coherence tomography is superior to intravascular ultrasound for diagnosis of distal-type chronic thromboembolic pulmonary hypertension. (23386271)
2013
10
Right ventricular longitudinal deformation parameters and exercise capacity : Prognosis of patients with chronic thromboembolic pulmonary hypertension. (23740084)
2013
11
Chronic thromboembolic pulmonary hypertension due to upper-extremity deep vein thrombosis caused by thoracic outlet syndrome. (22138476)
2012
12
Evolving surgical techniques for pulmonary endarterectomy according to the changing features of chronic thromboembolic pulmonary hypertension patients during 17-year single-center experience. (22498087)
2012
13
Chronic thromboembolic pulmonary hypertension with pulmonary infarction occuring in a hypertensive. (21970224)
2011
14
Clinical course of unoperated mild chronic thromboembolic pulmonary hypertension. (21594826)
2011
15
The incidence of recurrent venous thromboembolism and chronic thromboembolic pulmonary hypertension following a first episode of pulmonary embolism. (21743331)
2011
16
Surgical outcome of two difficult cases with predominant proximal pulmonary artery lesions of chronic thromboembolic pulmonary hypertension. (23555449)
2011
17
Recent advances in chronic thromboembolic pulmonary hypertension. (21620730)
2011
18
Single photon emission computed tomography in chronic thromboembolic pulmonary hypertension. (20920137)
2011
19
Clinical and haemodynamic evaluation of chronic thromboembolic pulmonary hypertension patients scheduled for pulmonary thromboendarterectomy: Is schistosomiasis hypertension an important confounding factor? (21243290)
2010
20
Clinical features and management of chronic thromboembolic pulmonary hypertension in Thai. (20364561)
2010
21
Bosentan for chronic thromboembolic pulmonary hypertension: findings from a systematic review and meta-analysis. (20172593)
2010
22
Long-term outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a single institution experience. (19272789)
2009
23
HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. (19165231)
2009
24
Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension. (18239156)
2008
25
Thromboendarterectomy for severe chronic thromboembolic pulmonary hypertension. (17540993)
2007
26
Role of NT-proBNP and 6MWD in chronic thromboembolic pulmonary hypertension. (17706409)
2007
27
Long-term bosentan in chronic thromboembolic pulmonary hypertension. (16699254)
2007
28
Chronic thromboembolic pulmonary hypertension - assessment by magnetic resonance imaging. (16838142)
2007
29
Effects of pulmonary thromboendarterectomy on right-sided echocardiographic parameters in patients with chronic thromboembolic pulmonary hypertension. (16770978)
2006
30
Assessment of operability in chronic thromboembolic pulmonary hypertension. (16963538)
2006
31
Angiotensin-converting enzyme gene polymorphisms and prognosis in chronic thromboembolic pulmonary hypertension. (16936432)
2006
32
Pulmonary artery-to-pulmonary artery anastomoses: angiographic demonstration in patients with chronic thromboembolic pulmonary hypertension. (16488207)
2006
33
Long-term recovery of exercise ability after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. (16996930)
2006
34
The efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension: a 1-year follow-up study. (16611652)
2006
35
Bosentan in inoperable chronic thromboembolic pulmonary hypertension. (16061720)
2005
36
Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension. (15735803)
2005
37
Chronic thromboembolic pulmonary hypertension. (15302364)
2004
38
Prostacyclin therapy before pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension. (12576349)
2003
39
High prevalence of elevated clotting factor VIII in chronic thromboembolic pulmonary hypertension. (12958604)
2003
40
Thrombophilic factors in chronic thromboembolic pulmonary hypertension. (11555695)
2001
41
Chronic thromboembolic pulmonary hypertension. (11590849)
2001
42
Plasma monocyte chemoattractant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hypertension. (11463608)
2001
43
Three-dimensional visualization of pulmonary thromboemboli in chronic thromboembolic pulmonary hypertension with multiple detector-row spiral computed tomography. (11413092)
2001
44
Surgical treatment of chronic thromboembolic pulmonary hypertension. (10700671)
2000
45
Chronic Thromboembolic Pulmonary Hypertension. (11096519)
2000
46
Surgical treatment for chronic thromboembolic pulmonary hypertension under profound hypothermia and circulatory arrest in 24 patients. (10875595)
1999
47
A successful case of pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension with a thrombus in the right ventricle. (10333425)
1999
48
Lupus anticoagulant, heparin use, and thrombocytopenia in patients with chronic thromboembolic pulmonary hypertension: a preliminary report. (7573095)
1995
49
Acute pulmonary embolism and chronic thromboembolic pulmonary hypertension: is there a relationship? (2044728)
1991
50
Chronic thromboembolic pulmonary hypertension following ventriculo-atrial shunting. (282858)
1978

Variations for Chronic Thromboembolic Pulmonary Hypertension

About this section

Expression for genes affiliated with Chronic Thromboembolic Pulmonary Hypertension

About this section
Search GEO for disease gene expression data for Chronic Thromboembolic Pulmonary Hypertension.

Pathways for genes affiliated with Chronic Thromboembolic Pulmonary Hypertension

About this section

Pathways related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6BMPR2, NPPB
29.2EDN1, NPPB
39.1EDN1, PTGIS
4
Show member pathways
9.0CRP, EDN1

GO Terms for genes affiliated with Chronic Thromboembolic Pulmonary Hypertension

About this section

Cellular components related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:000590110.1BMPR2, PTGIS
2extracellular regionGO:00055767.8CRP, EDN1, FGA, NPPB
3extracellular spaceGO:00056157.1BMPR2, CRP, EDN1, FGA, NPPB, PTGIS

Biological processes related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular response to interleukin-6GO:00713549.9FGA, PTGIS
2body fluid secretionGO:00075899.8EDN1, NPPB
3positive regulation of urine volumeGO:00358109.8EDN1, NPPB
4positive regulation of endothelial cell migrationGO:00105959.6BMPR2, EDN1
5acute-phase responseGO:00069539.6CRP, FGA
6negative regulation of cell growthGO:00303089.5BMPR2, NPPB
7prostaglandin biosynthetic processGO:00015169.4EDN1, PTGIS
8regulation of blood pressureGO:00082179.2EDN1, NPPB
9cellular response to interleukin-1GO:00713479.2EDN1, PTGIS
10cellular response to hypoxiaGO:00714569.1EDN1, PTGIS
11positive regulation of renal sodium excretionGO:00358158.9EDN1, NPPB

Molecular functions related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.5EDN1, NPPB
2receptor bindingGO:00051028.7EDN1, FGA, NPPB

Sources for Chronic Thromboembolic Pulmonary Hypertension

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet