CTEPH
MCID: CHR466
MIFTS: 39

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Chronic Thromboembolic Pulmonary Hypertension

Aliases & Descriptions for Chronic Thromboembolic Pulmonary Hypertension:

Name: Chronic Thromboembolic Pulmonary Hypertension 50 69
Cteph 50

Classifications:



Summaries for Chronic Thromboembolic Pulmonary Hypertension

NIH Rare Diseases : 50 chronic thromboembolic pulmonary hypertension (cteph) is a unique pulmonary vascular disease caused by chronic block of the major lung arteries. signs and symptoms commonly include progressive breathing difficulties (dyspnea) on exertion, fatigue, palpitations, loss of consciousness (syncope), or swelling (edema). the disease may appear a few months or many years after the sudden blockage in a lung artery by a blood clot (acute pulmonary embolism). however, up to 60% of patients have no history of acute pulmonary embolism. some people with this disease may have clotting problems. research suggests there may be a genetic predisposition leading to abnormal vascular healing after pulmonary embolism in susceptible individuals, but no specific gene mutations have been identified in cteph. curative treatment is done with pulmonary endarterectomy (a surgery that removes the blood clots in the lungs), and more recently by pulmonary balloon angioplasty (a procedure that opens up the vessels of the lung and increases blood flow).  last updated: 10/18/2016

MalaCards based summary : Chronic Thromboembolic Pulmonary Hypertension, also known as cteph, is related to artery disease and pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis. An important gene associated with Chronic Thromboembolic Pulmonary Hypertension is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Formation of Fibrin Clot (Clotting Cascade). The drugs Adempas and Bosentan have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and heart, and related phenotype is cardiovascular system.

Related Diseases for Chronic Thromboembolic Pulmonary Hypertension

Diseases related to Chronic Thromboembolic Pulmonary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
id Related Disease Score Top Affiliating Genes
1 artery disease 29.5 CRP F2
2 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 11.3
3 pulmonary hypertension 11.1
4 pulmonary embolism 10.4
5 unilateral multicystic dysplastic kidney 10.2 CRP NPPB
6 ectodermal dysplasia 9, hair/nail type 10.2 EDN1 NPPB
7 joint disorders 10.2 CRP NPPB
8 eastern equine encephalitis 10.2 EDN1 NPPB
9 secretory diarrhea myopathy and deafness 10.2 CRP FGA
10 toxic myocarditis 10.2 CRP NPPB
11 iida kannari syndrome 10.2 EDN1 NPPB
12 petrositis 10.1 EDN1 NPPB
13 lymphadenitis 10.1 EDN1 NPPB
14 enamel hypoplasia cataract hydrocephaly 10.1 BMPR2 EDN1
15 hematocele of tunica vaginalis testis 10.1 BMPR2 EDN1
16 afibrinogenemia, congenital 10.1 FGA FGB
17 endotheliitis 10.1
18 thrombosis 10.1
19 pancreas lymphoma 10.1 CRP NPPB
20 hemorrhoid 10.1 CRP EDN1
21 urinary bladder posterior wall cancer 10.1 CRP NPPB
22 deafness, autosomal recessive 79 10.1 CRP NPPB
23 autonomic neuropathy 10.1 F2 NPPB
24 acute closed-angle glaucoma 10.0 EDN1 NPPB
25 acute infection of pinna 10.0 CRP F2
26 synostosis 10.0 CRP F2
27 midline cystocele 10.0 CRP F2
28 houlston ironton temple syndrome 10.0 CRP F2
29 myopia 10.0 EDN1 F2
30 diabetic encephalopathy 10.0 CRP EDN1 NPPB
31 adult t-cell leukemia 10.0 CRP EDN1 NPPB
32 intestinal disaccharidase deficiency 10.0 CRP F2
33 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.0 CRP F2
34 ceroid lipofuscinosis, neuronal, 8 10.0 CRP EDN1 NPPB
35 antiphospholipid syndrome 10.0
36 sarcoma 10.0
37 villous adenoma 10.0 CRP F2
38 macular degeneration, age-related, 12 10.0 CRP EDN1 NPPB
39 xerophthalmia 10.0 CRP F2
40 alpha-2-plasmin inhibitor deficiency 10.0 EDN1 F2
41 pregnancy loss, recurrent 1 9.9 F2 FGA
42 essential thrombocythemia 9.9 F2 FGB
43 autoimmune disease of central nervous system 9.9 CRP F2
44 capillary hemangioma 9.9 EDN1 F2
45 ischemic optic neuropathy 9.9 CRP F2
46 immunodeficiency 21 9.9 F2 FGA
47 atrophy of prostate 9.9 CRP F2
48 benign deep fibrous histiocytoma 9.9 F2 FGB
49 dysfibrinogenemia 9.9
50 brill-zinsser disease 9.9 F2 FGA

Graphical network of the top 20 diseases related to Chronic Thromboembolic Pulmonary Hypertension:



Diseases related to Chronic Thromboembolic Pulmonary Hypertension

Symptoms & Phenotypes for Chronic Thromboembolic Pulmonary Hypertension

MGI Mouse Phenotypes related to Chronic Thromboembolic Pulmonary Hypertension:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 BMPR2 CRP EDN1 F2 FGA FGB

Drugs & Therapeutics for Chronic Thromboembolic Pulmonary Hypertension

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Adempas 17 RIOCIGUAT Bayer Healthcare Pharmaceuticals Approved October 2013

Drugs for Chronic Thromboembolic Pulmonary Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 3,Phase 1,Phase 2 147536-97-8 104865
2
Treprostinil Approved, Investigational Phase 3 81846-19-7 54786 6918140
3 Endothelin Receptor Antagonists Phase 3,Phase 2,Phase 1
4 Antihypertensive Agents Phase 3,Phase 2,Phase 1
5 Calamus Nutraceutical Phase 3
6
Macitentan Approved Phase 2 441798-33-0
7 adrenomedullin Phase 2
8 Peripheral Nervous System Agents Phase 2
9 Vasodilator Agents Phase 2
10 Endothelin A Receptor Antagonists Phase 2
11 Anti-Asthmatic Agents Phase 2
12 Fluorodeoxyglucose F18 Phase 2,Phase 1
13 Protective Agents Phase 2
14 Radiopharmaceuticals Phase 2,Phase 1
15 Respiratory System Agents Phase 2
16 Autonomic Agents Phase 2
17 Bronchodilator Agents Phase 2
18 Deoxyglucose Phase 1, Phase 2
19 Anti-Infective Agents Phase 1, Phase 2
20 Antimetabolites Phase 1, Phase 2
21 Antiviral Agents Phase 1, Phase 2
22
Warfarin Approved 81-81-2 6691 54678486
23
Rivaroxaban Approved 366789-02-8
24
Iloprost Approved, Investigational 78919-13-8 6443959
25
Tadalafil Approved, Investigational 171596-29-5 110635
26 Thrombin
27
protease inhibitors
28 Serine Proteinase Inhibitors
29 HIV Protease Inhibitors
30 Factor Xa Inhibitors
31 Anticoagulants
32 Antithrombin III
33 Antithrombins
34 Tezosentan
35 Sildenafil Citrate 171599-83-0
36 Phosphodiesterase 5 Inhibitors
37 Immunoglobulins
38 Antibodies
39 Autoantibodies
40 serine Nutraceutical

Interventional clinical trials:

(show top 50) (show all 60)
id Name Status NCT ID Phase
1 Influence of Respiratory and Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA Unknown status NCT01393327 Phase 3
2 Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension Completed NCT00313222 Phase 3
3 Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension Completed NCT01884012 Phase 3
4 Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Completed NCT00319111 Phase 3
5 A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH. Completed NCT00855465 Phase 3
6 CTEPH DIAGNOSIS Europe - MRI Recruiting NCT02791282 Phase 3
7 Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH) Active, not recruiting NCT01416636 Phase 3
8 BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT00910429 Phase 3
9 Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension. Terminated NCT01884675 Phase 3
10 A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Terminated NCT01894022 Phase 3
11 Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Completed NCT02021292 Phase 2
12 Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH Completed NCT02094001 Phase 2
13 Effect of Short-term Oxygen During CPET in Pulmonary Hypertension Completed NCT01748474 Phase 2
14 An Open Multiple Dose Titration Study In Patients With Pulmonary Hypertension Completed NCT00454558 Phase 2
15 Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension Completed NCT02216279 Phase 2
16 Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy Recruiting NCT02745106 Phase 2
17 Bosentan in Myocardium Metabolism and Perfusion Measured by 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and Rubidium-82 (82Rb) Positron Emission Tomography/Computed Tomography (PET/CTs) on Pulmonary Arterial Hypertension (PAH) or Chronic Thromboembolic Pulmo Recruiting NCT02970851 Phase 1, Phase 2
18 Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT02060721 Phase 2
19 Cell Proliferation in Pulmonary Hypertension. FDG-PET Comparison Between Patients and Healthy Subjects Not yet recruiting NCT02886793 Phase 1, Phase 2
20 Latent Pulmonary Hypertension (PH) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH )After Endarterectomy and Influence of Exercise and Respiratory Therapy Unknown status NCT00477724
21 Right Ventricular Resynchronization Therapy Unknown status NCT01163422
22 3D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary Endarterectomy Unknown status NCT02426203
23 Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism Unknown status NCT01672203
24 Epidemiological Study of Chronic Thromboembolic Pulmonary Hypertension in China Unknown status NCT01717092
25 Gene Mutations in Secondary Pulmonary Hypertension Unknown status NCT00348803
26 Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging Completed NCT02114047
27 A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice Completed NCT02545465
28 Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension Completed NCT02536534
29 Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients Completed NCT00747045
30 Study on the Clinical Course Of Pulmonary Embolism Completed NCT01781858
31 Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic Hypertension Completed NCT00657722
32 Smoking: a Risk Factor for Pulmonary Arterial Hypertension? Completed NCT01484899
33 RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter Defibrillators Completed NCT02111980
34 Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension Recruiting NCT02634203
35 Sleep Disorder Breathing in Chronic Thromboembolic Pulmonary Hypertension Recruiting NCT03074539
36 Prospective Registry to Evaluate the Effective Incidence of Chronic Thromboembolic Pulmonary Hypertension in Germany Recruiting NCT02660463
37 Registry for Pulmonary Hypertension in China Recruiting NCT01417338
38 A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries Recruiting NCT02637050
39 U.S. CTEPH Registry Recruiting NCT02429284
40 Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH ) Recruiting NCT02117791
41 Balloon Pulmonary Angioplasty in Non-operable CTEPH Patients Recruiting NCT02964390
42 Long Term Outcomes of Venous Thromboembolism Recruiting NCT02268630
43 Effect of Exercise Training in Patients With Pulmonary Hypertension Recruiting NCT02558582
44 Early Non-invasive Detection of CTEPH After Pulmonary Embolism Recruiting NCT02555137
45 Sleep Disordered Breathing in Precapillary Pulmonary Hypertension: Effect of CPAP Treatment Recruiting NCT02583906
46 Six Years of Follow-up After Idiopathic Venous Throbmoembolism Recruiting NCT02884934
47 Follow-up in Rivaroxaban Patients in Setting of Thromboembolism Recruiting NCT02248610
48 Global Anticoagulant Registry in the FIELD- Venous Thromboembolic Events Recruiting NCT02155491
49 CTEPH Identification an Standard Computerised Tomography Pulmonary Angiography in Pulmonary Embolism Patients Recruiting NCT03083093
50 Zürich Pulmonary Hypertension Outcome Assessment Cohort Recruiting NCT02249806

Search NIH Clinical Center for Chronic Thromboembolic Pulmonary Hypertension

Genetic Tests for Chronic Thromboembolic Pulmonary Hypertension

Anatomical Context for Chronic Thromboembolic Pulmonary Hypertension

MalaCards organs/tissues related to Chronic Thromboembolic Pulmonary Hypertension:

39
Lung, Endothelial, Heart, Brain, Neutrophil, Smooth Muscle, Monocytes

Publications for Chronic Thromboembolic Pulmonary Hypertension

Articles related to Chronic Thromboembolic Pulmonary Hypertension:

(show top 50) (show all 497)
id Title Authors Year
1
Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target. ( 28289017 )
2017
2
Transition of Intravenous Treprostinil to Oral Therapy in a Patient with Functional Class IV Chronic Thromboembolic Pulmonary Hypertension. ( 28513869 )
2017
3
Depressive Status in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28529263 )
2017
4
Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: Correlation with perfusion SPECT/CT. ( 28526539 )
2017
5
Epidemiology and management of chronic thromboembolic pulmonary hypertension: Experience from two expert centers. ( 28528258 )
2017
6
To screen or not to screen for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. ( 28073030 )
2017
7
An Update on the Management of Chronic Thromboembolic Pulmonary Hypertension. ( 27989311 )
2017
8
Imaging in Chronic Thromboembolic Pulmonary Hypertension. ( 28060193 )
2017
9
Combination therapy with riociquat and inhaled treprostinil in inoperable and progressive chronic thromboembolic pulmonary hypertension. ( 27942445 )
2017
10
A chronic thromboembolic pulmonary hypertension catch-22 situation: inferior vena caval filter plays a pivotal role in an unlikely situation. ( 28523175 )
2017
11
Energy efficiency and pulmonary artery flow after balloon pulmonary angioplasty for inoperable, chronic thromboembolic pulmonary hypertension: Analysis by phase-contrast MRI. ( 28065382 )
2017
12
A Review of Clinical Trial Endpoints of Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension and How They Relate to Patient Outcomes in the United States. ( 28025931 )
2017
13
Percutaneous treatment of chronic thromboembolic pulmonary hypertension (CTEPH). ( 27174110 )
2016
14
Clinical usefulness of end-tidal CO2 profiles during incremental exercise in patients with chronic thromboembolic pulmonary hypertension. ( 27817818 )
2016
15
Familial chronic thromboembolic pulmonary hypertension in aA mother and aA son: successful treatment with refined balloon pulmonary angioplasty. ( 28010001 )
2016
16
Thrombin-Activatable Fibrinolysis Inhibitor in Chronic Thromboembolic Pulmonary Hypertension. ( 27102961 )
2016
17
Information, social support and coping in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension-A nationwide population-based study. ( 28041647 )
2016
18
Quality of life in patients with chronic thromboembolic pulmonary hypertension. ( 27076580 )
2016
19
Pulmonary arteriovenous malformation in chronic thromboembolic pulmonary hypertension. ( 27413264 )
2016
20
Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension. ( 27097557 )
2016
21
An international physician survey of chronic thromboembolic pulmonary hypertension management. ( 28090289 )
2016
22
Predictors of long-term outcomes in patients treated with riociguat for chronic thromboembolic pulmonary hypertension: data from the CHEST-2 open-label, randomised, long-term extension trial. ( 27067478 )
2016
23
TCT-91 Efficacy of aggressive balloon pulmonary angioplasty on chronic thromboembolic pulmonary hypertension beyond normalized mean pulmonary arterial pressure. ( 27970256 )
2016
24
Population pharmacokinetics and the pharmacokinetic/pharmacodynamic relationship of riociguat in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension. ( 27162632 )
2016
25
Native T1 mapping and extracellular volume fraction measurement for assessment of right ventricular insertion point and septal fibrosis in chronic thromboembolic pulmonary hypertension. ( 27651142 )
2016
26
Efficacy and safety of balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension guided by cone-beam computed tomography and electrocardiogram-gated area detector computed tomography. ( 28034568 )
2016
27
TCT-90 Efficacy and safety of sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension. ( 27970252 )
2016
28
Long-Term Outcomes After Percutaneous Transluminal Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. ( 27956405 )
2016
29
TCT-92 Short- and Long-Term Remodeling of Pulmonary Arteries After Balloon Angioplasty in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension. ( 27970255 )
2016
30
The role of mononuclear cell tissue factor and inflammatory cytokines in patients with chronic thromboembolic pulmonary hypertension. ( 26667361 )
2016
31
TCT-771 Clinical and Hemodynamic Efficacy of Balloon Pulmonary Angioplasty forA Inoperable Chronic Thromboembolic Pulmonary Hypertension: AA Meta-Analysis. ( 27970157 )
2016
32
Choriocarcinoma mimicking chronic thromboembolic pulmonary hypertension. ( 26916795 )
2016
33
Spontaneous enlargement of pulmonary artery after successful balloon pulmonary angioplasty in a patient with chronic thromboembolic pulmonary hypertension. ( 27934612 )
2016
34
Risk factors detection in chronic thromboembolic pulmonary hypertension, a tool for risk quantification? ( 27826972 )
2016
35
Re: Outcome after surgical treatment of chronic thromboembolic pulmonary hypertension: dealing with different patient subsets. A single-centre experience. ( 27147627 )
2016
36
Successful balloon pulmonary angioplasty with gadolinium contrast media for a patient with chronic thromboembolic pulmonary hypertension and iodine allergy. ( 27141436 )
2016
37
Haemodynamic effects of riociguat in inoperable/recurrent chronic thromboembolic pulmonary hypertension. ( 28011757 )
2016
38
Fractional Flow Reserve-guided Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension. ( 27052125 )
2016
39
Chronic thromboembolic pulmonary hypertension - a diagnostic and therapeutic update. ( 27128884 )
2016
40
REDUCED FORCE OF DIAPHRAGM MUSCLE FIBERS IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION. ( 27190061 )
2016
41
Review of the Association between Splenectomy and Chronic Thromboembolic Pulmonary Hypertension. ( 27058013 )
2016
42
Insights into ventilation-gas exchange coupling in chronic thromboembolic pulmonary hypertension. ( 27076589 )
2016
43
Pulmonary endarterectomy for the treatment of chronic thromboembolic pulmonary hypertension. ( 27070482 )
2016
44
Beneficial Therapeutic Effects of Balloon Pulmonary Angioplasty on Biventricular Function in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 27170202 )
2016
45
CXCL13 in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. ( 26927848 )
2016
46
Development and Characterization of an Inducible Rat Model of Chronic Thromboembolic Pulmonary Hypertension. ( 27045032 )
2016
47
High prevalence of severe coronary artery disease in elderly patients with non-operable chronic thromboembolic pulmonary hypertension referred for balloon pulmonary angioplasty. ( 27980550 )
2016
48
Endothelin ETA receptors predominate in chronic thromboembolic pulmonary hypertension. ( 26874031 )
2016
49
Pulmonary vascular morphology as an imaging biomarker in chronic thromboembolic pulmonary hypertension. ( 27162616 )
2016
50
Outcome after surgical treatment of chronic thromboembolic pulmonary hypertension: dealing with different patient subsets. A single-centre experience. ( 27072006 )
2016

Variations for Chronic Thromboembolic Pulmonary Hypertension

Expression for Chronic Thromboembolic Pulmonary Hypertension

Search GEO for disease gene expression data for Chronic Thromboembolic Pulmonary Hypertension.

Pathways for Chronic Thromboembolic Pulmonary Hypertension

Pathways related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.38 EDN1 F2 FGA FGB
2
Show member pathways
11.64 F2 FGA FGB
3 11.47 F2 FGA FGB
4 11.12 FGA FGB
5
Show member pathways
11.12 F2 FGA FGB
6
Show member pathways
10.88 CRP EDN1
7 10.71 BMPR2 NPPB
8 10.51 F2 FGA FGB

GO Terms for Chronic Thromboembolic Pulmonary Hypertension

Cellular components related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 CRP EDN1 F2 FGA FGB NPPB
2 external side of plasma membrane GO:0009897 9.54 F2 FGA FGB
3 blood microparticle GO:0072562 9.5 F2 FGA FGB
4 platelet alpha granule lumen GO:0031093 9.43 FGA FGB
5 extracellular vesicle GO:1903561 9.4 FGA FGB
6 platelet alpha granule GO:0031091 9.26 FGA FGB
7 extracellular space GO:0005615 9.17 BMPR2 CRP EDN1 F2 FGA FGB
8 fibrinogen complex GO:0005577 8.96 FGA FGB

Biological processes related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.78 EDN1 F2 NPPB
2 blood coagulation GO:0007596 9.72 F2 FGA FGB
3 cellular response to interleukin-1 GO:0071347 9.64 EDN1 FGB
4 regulation of blood pressure GO:0008217 9.64 EDN1 NPPB
5 response to calcium ion GO:0051592 9.63 FGA FGB
6 positive regulation of endothelial cell migration GO:0010595 9.63 BMPR2 EDN1
7 toll-like receptor signaling pathway GO:0002224 9.62 FGA FGB
8 platelet aggregation GO:0070527 9.62 FGA FGB
9 positive regulation of protein secretion GO:0050714 9.61 FGA FGB
10 acute-phase response GO:0006953 9.6 CRP F2
11 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.59 FGA FGB
12 positive regulation of vasoconstriction GO:0045907 9.58 FGA FGB
13 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.58 FGA FGB
14 platelet activation GO:0030168 9.58 F2 FGA FGB
15 negative regulation of endothelial cell apoptotic process GO:2000352 9.57 FGA FGB
16 positive regulation of exocytosis GO:0045921 9.56 FGA FGB
17 cellular protein complex assembly GO:0043623 9.54 FGA FGB
18 regulation of blood vessel size GO:0050880 9.52 EDN1 NPPB
19 positive regulation of urine volume GO:0035810 9.51 EDN1 NPPB
20 positive regulation of renal sodium excretion GO:0035815 9.49 EDN1 NPPB
21 protein polymerization GO:0051258 9.48 FGA FGB
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.46 FGA FGB
23 plasminogen activation GO:0031639 9.43 FGA FGB
24 body fluid secretion GO:0007589 9.37 EDN1 NPPB
25 positive regulation of peptide hormone secretion GO:0090277 9.32 FGA FGB
26 blood coagulation, fibrin clot formation GO:0072378 9.26 FGA FGB
27 induction of bacterial agglutination GO:0043152 9.16 FGA FGB
28 hemostasis GO:0007599 9.13 F2 FGA FGB
29 fibrinolysis GO:0042730 8.8 F2 FGA FGB

Molecular functions related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.02 EDN1 F2 FGA FGB NPPB
2 cell adhesion molecule binding GO:0050839 8.96 FGA FGB

Sources for Chronic Thromboembolic Pulmonary Hypertension

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
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48 NDF-RT
51 NINDS
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54 OMIM
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