MCID: CHR466
MIFTS: 38

Chronic Thromboembolic Pulmonary Hypertension

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Chronic Thromboembolic Pulmonary Hypertension

MalaCards integrated aliases for Chronic Thromboembolic Pulmonary Hypertension:

Name: Chronic Thromboembolic Pulmonary Hypertension 50 69
Cteph 50

Classifications:



Summaries for Chronic Thromboembolic Pulmonary Hypertension

NIH Rare Diseases : 50 chronic thromboembolic pulmonary hypertension (cteph) is a unique pulmonary vascular disease caused by chronic block of the major lung arteries. signs and symptoms commonly include progressive breathing difficulties (dyspnea) on exertion, fatigue, palpitations, loss of consciousness (syncope), or swelling (edema). the disease may appear a few months or many years after the sudden blockage in a lung artery by a blood clot (acute pulmonary embolism). however, up to 60% of patients have no history of acute pulmonary embolism. some people with this disease may have clotting problems. research suggests there may be a genetic predisposition leading to abnormal vascular healing after pulmonary embolism in susceptible individuals, but no specific genemutations have been identified in cteph. curative treatment is done with pulmonary endarterectomy (a surgery that removes the blood clots in the lungs), and more recently by pulmonary balloon angioplasty (a procedure that opens up the vessels of the lung and increases blood flow).  last updated: 10/18/2016

MalaCards based summary : Chronic Thromboembolic Pulmonary Hypertension, also known as cteph, is related to pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis and pulmonary hypertension. An important gene associated with Chronic Thromboembolic Pulmonary Hypertension is FGA (Fibrinogen Alpha Chain), and among its related pathways/superpathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Cell adhesion_Plasmin signaling. The drugs Adempas and Bosentan have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial.

Wikipedia : 72 Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term disease caused by a blockage in the... more...

Related Diseases for Chronic Thromboembolic Pulmonary Hypertension

Diseases related to Chronic Thromboembolic Pulmonary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Related Disease Score Top Affiliating Genes
1 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 11.2
2 pulmonary hypertension 11.1
3 pulmonary embolism 10.4
4 chronic diarrhea due to guanylate cyclase 2c overactivity 10.3 CRP FGA
5 lethal congenital contractural syndrome 2 10.3 EDN1 NPPB
6 islet cell tumor 10.3 CRP NPPB
7 idiopathic juxtafoveal retinal telangiectasia 10.3 EDN1 NPPB
8 placental abruption 10.3 CRP NPPB
9 elizabethkingia anophelis infection 10.3 BMPR2 EDN1
10 hematocele of tunica vaginalis testis 10.2 BMPR2 EDN1
11 broad ligament malignant neoplasm 10.2 EDN1 NPPB
12 urinary bladder posterior wall cancer 10.2 CRP NPPB
13 pancreas lymphoma 10.2 CRP NPPB
14 prostate malignant phyllodes tumor 10.2 CRP NPPB
15 eustachian tube disease 10.2 CRP EDN1
16 adams-oliver syndrome 5 10.2 CRP NPPB
17 acute closed-angle glaucoma 10.1 EDN1 NPPB
18 thrombosis 10.1
19 endotheliitis 10.1
20 meckel's diverticulum 10.1 CRP NPPB
21 amyloidosis, familial visceral 10.0 FGA FGB
22 sarcoma 10.0
23 antiphospholipid syndrome 10.0
24 dyskeratosis congenita autosomal recessive 10.0 FGA FGB
25 diabetic encephalopathy 10.0 CRP EDN1
26 van maldergem syndrome 2 10.0 FGA FGB
27 bubonic plague 9.9 BMPR2 EDN1
28 craniosynostosis 7 9.9 CRP NPPB
29 diamond-blackfan anemia 1 9.9 CRP NPPB
30 agenesis of the dorsal pancreas 9.9 FGA FGB
31 dysfibrinogenemia 9.9
32 pyelonephritis 9.8 CRP EDN1 NPPB
33 periampullary adenoma 9.8 CRP EDN1 NPPB
34 adult respiratory distress syndrome 9.8 CRP EDN1 NPPB
35 peripheral artery disease 9.8 CRP EDN1 NPPB
36 hypothyroidism, congenital nongoitrous, 5 9.8 CRP EDN1 NPPB
37 lubani-al saleh-teebi syndrome 9.8 BMPR2 EDN1 NPPB
38 coronary artery disease 9.7
39 takayasu arteritis 9.7
40 hereditary hemorrhagic telangiectasia 9.7
41 sinusitis 9.7
42 thrombocytopenia 9.7
43 artery disease 9.7
44 arteriovenous malformation 9.7
45 heart disease 9.7
46 esophagitis 9.7
47 schistosomiasis 9.7
48 post-thrombotic syndrome 9.7
49 thoracic outlet syndrome 9.7
50 cerebritis 9.7

Graphical network of the top 20 diseases related to Chronic Thromboembolic Pulmonary Hypertension:



Diseases related to Chronic Thromboembolic Pulmonary Hypertension

Symptoms & Phenotypes for Chronic Thromboembolic Pulmonary Hypertension

Drugs & Therapeutics for Chronic Thromboembolic Pulmonary Hypertension

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Adempas 17 RIOCIGUAT Bayer Healthcare Pharmaceuticals October 2013

Drugs for Chronic Thromboembolic Pulmonary Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 3,Phase 1,Phase 2 147536-97-8 104865
2
Treprostinil Approved, Investigational Phase 3 81846-19-7 54786 6918140
3 Antihypertensive Agents Phase 3,Phase 2,Phase 1
4 Endothelin Receptor Antagonists Phase 3,Phase 2,Phase 1
5 Calamus Nutraceutical Phase 3
6
Macitentan Approved Phase 2 441798-33-0
7 Endothelin A Receptor Antagonists Phase 2
8 Fluorodeoxyglucose F18 Phase 2,Phase 1
9 Radiopharmaceuticals Phase 2,Phase 1
10 adrenomedullin Phase 2
11 Anti-Asthmatic Agents Phase 2
12 Autonomic Agents Phase 2
13 Bronchodilator Agents Phase 2
14 Peripheral Nervous System Agents Phase 2
15 Protective Agents Phase 2
16 Respiratory System Agents Phase 2
17 Vasodilator Agents Phase 2
18 Anti-Infective Agents Phase 1, Phase 2
19 Antimetabolites Phase 1, Phase 2
20 Antiviral Agents Phase 1, Phase 2
21 Deoxyglucose Phase 1, Phase 2
22
Thrombin Approved
23
Rivaroxaban Approved 366789-02-8
24
Warfarin Approved 81-81-2 6691 54678486
25
Iloprost Approved, Investigational 78919-13-8 6443959
26
Tadalafil Approved, Investigational 171596-29-5 110635
27 Antibodies
28 Autoantibodies
29 Immunoglobulins
30 interferons
31 Anticoagulants
32 Coagulants
33 Hemostatics
34 Antithrombin III
35 Antithrombins
36 Factor Xa Inhibitors
37 HIV Protease Inhibitors
38
protease inhibitors
39 Serine Proteinase Inhibitors
40 Anesthetics
41 Phosphodiesterase 5 Inhibitors
42 Sildenafil Citrate 171599-83-0
43 Tezosentan
44 serine Nutraceutical

Interventional clinical trials:

(show top 50) (show all 67)

id Name Status NCT ID Phase Drugs
1 Influence of Respiratory and Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA Unknown status NCT01393327 Phase 3
2 Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension Completed NCT00313222 Phase 3 bosentan
3 Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension Completed NCT01884012 Phase 3
4 Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Completed NCT00319111 Phase 3 bosentan
5 A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH. Completed NCT00855465 Phase 3 Riociguat (Adempas, BAY63-2521);Placebo
6 CTEPH DIAGNOSIS Europe - MRI Recruiting NCT02791282 Phase 3
7 Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH) Active, not recruiting NCT01416636 Phase 3 Treprostinil sodium
8 BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT00910429 Phase 3 Riociguat (Adempas, BAY63-2521)
9 Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension. Terminated NCT01884675 Phase 3 Ambrisentan 5 mg;Placebo
10 A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Terminated NCT01894022 Phase 3 Ambrisentan 5 mg
11 Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Completed NCT02021292 Phase 2 Macitentan;Placebo
12 Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH Completed NCT02094001 Phase 2
13 Effect of Short-term Oxygen During CPET in Pulmonary Hypertension Completed NCT01748474 Phase 2
14 An Open Multiple Dose Titration Study In Patients With Pulmonary Hypertension Completed NCT00454558 Phase 2 Riociguat (Adempas, BAY63-2521)
15 Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension Completed NCT02216279 Phase 2 PulmoBind
16 Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy Recruiting NCT02745106 Phase 2
17 Bosentan in Myocardium Metabolism and Perfusion Measured by 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and Rubidium-82 (82Rb) Positron Emission Tomography/Computed Tomography (PET/CTs) on Pulmonary Arterial Hypertension (PAH) or Chronic Thromboembolic Pulmo Recruiting NCT02970851 Phase 1, Phase 2
18 Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT02060721 Phase 2 Macitentan
19 Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) Not yet recruiting NCT03273257 Phase 2 Riociguat;Placebo
20 Cell Proliferation in Pulmonary Hypertension. FDG-PET Comparison Between Patients and Healthy Subjects Not yet recruiting NCT02886793 Phase 1, Phase 2 fludeoxyglucose
21 Latent Pulmonary Hypertension (PH) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH )After Endarterectomy and Influence of Exercise and Respiratory Therapy Unknown status NCT00477724
22 Right Ventricular Resynchronization Therapy Unknown status NCT01163422
23 3D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary Endarterectomy Unknown status NCT02426203
24 Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism Unknown status NCT01672203
25 Epidemiological Study of Chronic Thromboembolic Pulmonary Hypertension in China Unknown status NCT01717092
26 Gene Mutations in Secondary Pulmonary Hypertension Unknown status NCT00348803
27 Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging Completed NCT02114047
28 A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice Completed NCT02545465 Riociguat (Adempas, BAY63-2521)
29 Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension Completed NCT02536534
30 Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients Completed NCT00747045
31 Study on the Clinical Course Of Pulmonary Embolism Completed NCT01781858
32 Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic Hypertension Completed NCT00657722
33 Smoking: a Risk Factor for Pulmonary Arterial Hypertension? Completed NCT01484899
34 RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter Defibrillators Completed NCT02111980
35 Auto-immunity and Pulmonary Arterial Hypertension Completed NCT01208792
36 Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension Recruiting NCT02634203 Riociguat
37 Sleep Disorder Breathing in Chronic Thromboembolic Pulmonary Hypertension Recruiting NCT03074539 Riociguat
38 Prospective Registry to Evaluate the Effective Incidence of Chronic Thromboembolic Pulmonary Hypertension in Germany Recruiting NCT02660463
39 Registry for Pulmonary Hypertension in China Recruiting NCT01417338
40 Determinants of Right Heart Remodeling in Patients With CTEPH or PAH Recruiting NCT03205085
41 Assessment of Blood Coagulation Disorders in Patients With Pulmonary Hypertension Recruiting NCT03195543
42 A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries Recruiting NCT02637050
43 Retrospective Data Analysis of Data From the Zurich PH Registry Recruiting NCT03198910
44 U.S. CTEPH Registry Recruiting NCT02429284
45 Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH ) Recruiting NCT02117791 Riociguat (ADEMPAS, BAY63-2521)
46 Balloon Pulmonary Angioplasty in Non-operable CTEPH Patients Recruiting NCT02964390
47 The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging Recruiting NCT03199131
48 Long Term Outcomes of Venous Thromboembolism Recruiting NCT02268630
49 Effect of Exercise Training in Patients With Pulmonary Hypertension Recruiting NCT02558582
50 Early Non-invasive Detection of CTEPH After Pulmonary Embolism Recruiting NCT02555137

Search NIH Clinical Center for Chronic Thromboembolic Pulmonary Hypertension

Genetic Tests for Chronic Thromboembolic Pulmonary Hypertension

Anatomical Context for Chronic Thromboembolic Pulmonary Hypertension

MalaCards organs/tissues related to Chronic Thromboembolic Pulmonary Hypertension:

39
Lung, Heart, Endothelial, Brain, Neutrophil, Monocytes, Smooth Muscle

Publications for Chronic Thromboembolic Pulmonary Hypertension

Articles related to Chronic Thromboembolic Pulmonary Hypertension:

(show top 50) (show all 517)
id Title Authors Year
1
Chronic Thromboembolic Pulmonary Hypertension: Epidemiology, Diagnosis, and Management. ( 28832374 )
2017
2
Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target. ( 28289017 )
2017
3
Imaging in Chronic Thromboembolic Pulmonary Hypertension. ( 28060193 )
2017
4
Novel Predictor of Lung Injury After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28717116 )
2017
5
An Update on the Management of Chronic Thromboembolic Pulmonary Hypertension. ( 27989311 )
2017
6
Epidemiology and management of chronic thromboembolic pulmonary hypertension: Experience from two expert centers. ( 28528258 )
2017
7
Stepwise optimisation of balloon pulmonary angioplasty in a patient with severe non-operable chronic thromboembolic pulmonary hypertension. ( 28691912 )
2017
8
Associations of Exercise Tolerance With Hemodynamic Parameters for Pulmonary Arterial Hypertension and for Chronic Thromboembolic Pulmonary Hypertension. ( 28671932 )
2017
9
Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension. ( 28682884 )
2017
10
Plexiform Vasculopathy in Chronic Thromboembolic Pulmonary Hypertension. ( 28892403 )
2017
11
Riociguat for patients with chronic thromboembolic pulmonary hypertension: Usefulness of transitioning from phosphodiesterase type 5 inhibitor. ( 28705306 )
2017
12
A Review of Clinical Trial Endpoints of Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension and How They Relate to Patient Outcomes in the United States. ( 28025931 )
2017
13
Extensive revascularization by balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension beyond hemodynamic normalization. ( 28804055 )
2017
14
Mosaic attenuation pattern in non-contrast computed tomography for the assessment of pulmonary perfusion in chronic thromboembolic pulmonary hypertension. ( 28942885 )
2017
15
Modern diagnosis of chronic thromboembolic pulmonary hypertension. ( 28918335 )
2017
16
Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. ( 28750932 )
2017
17
Early Development of Right Ventricular Ischemic Lesions in a Novel Large Animal Model of Acute Right Heart Failure in Chronic Thromboembolic Pulmonary Hypertension. ( 28801076 )
2017
18
Energy efficiency and pulmonary artery flow after balloon pulmonary angioplasty for inoperable, chronic thromboembolic pulmonary hypertension: Analysis by phase-contrast MRI. ( 28065382 )
2017
19
Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study. ( 28919201 )
2017
20
Depressive Status in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28529263 )
2017
21
Tidal Carbon Dioxide as a Prognostic Feature in Inoperable Chronic Thromboembolic Pulmonary Hypertension. ( 28806531 )
2017
22
Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: Correlation with perfusion SPECT/CT. ( 28526539 )
2017
23
To screen or not to screen for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. ( 28073030 )
2017
24
Reply: Tidal Carbon Dioxide as a Prognostic Feature in Inoperable Chronic Thromboembolic Pulmonary Hypertension. ( 28806530 )
2017
25
Microarray Analysis and Detection of MicroRNAs Associated with Chronic Thromboembolic Pulmonary Hypertension. ( 28904974 )
2017
26
Transition of Intravenous Treprostinil to Oral Therapy in a Patient with Functional Class IV Chronic Thromboembolic Pulmonary Hypertension. ( 28513869 )
2017
27
A chronic thromboembolic pulmonary hypertension catch-22 situation: inferior vena caval filter plays a pivotal role in an unlikely situation. ( 28523175 )
2017
28
Individual dose adjustment of riociguat in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. ( 28732819 )
2017
29
The Challenge in Diagnosis and Current Treatment of Chronic Thromboembolic Pulmonary Hypertension. ( 28790235 )
2017
30
Combination therapy with riociquat and inhaled treprostinil in inoperable and progressive chronic thromboembolic pulmonary hypertension. ( 27942445 )
2017
31
Pulmonary Artery Diameter Predicts Lung Injury After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28701673 )
2017
32
The effective systematic heparin pre-treatment on thrombus formation on pulmonary artery catheter tips during pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a randomized, double-blind study. ( 28875371 )
2017
33
Efficacy and safety of balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension guided by cone-beam computed tomography and electrocardiogram-gated area detector computed tomography. ( 28034568 )
2016
34
TCT-771 Clinical and Hemodynamic Efficacy of Balloon Pulmonary Angioplasty forA Inoperable Chronic Thromboembolic Pulmonary Hypertension: AA Meta-Analysis. ( 27970157 )
2016
35
Risk factors detection in chronic thromboembolic pulmonary hypertension, a tool for risk quantification? ( 27826972 )
2016
36
Beneficial Therapeutic Effects of Balloon Pulmonary Angioplasty on Biventricular Function in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 27170202 )
2016
37
Spontaneous enlargement of pulmonary artery after successful balloon pulmonary angioplasty in a patient with chronic thromboembolic pulmonary hypertension. ( 27934612 )
2016
38
Clinical usefulness of end-tidal CO2 profiles during incremental exercise in patients with chronic thromboembolic pulmonary hypertension. ( 27817818 )
2016
39
Pulmonary arteriovenous malformation in chronic thromboembolic pulmonary hypertension. ( 27413264 )
2016
40
Insights into ventilation-gas exchange coupling in chronic thromboembolic pulmonary hypertension. ( 27076589 )
2016
41
Re: Outcome after surgical treatment of chronic thromboembolic pulmonary hypertension: dealing with different patient subsets. A single-centre experience. ( 27147627 )
2016
42
Fractional Flow Reserve-guided Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension. ( 27052125 )
2016
43
Population pharmacokinetics and the pharmacokinetic/pharmacodynamic relationship of riociguat in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension. ( 27162632 )
2016
44
Long-Term Outcomes After Percutaneous Transluminal Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. ( 27956405 )
2016
45
REDUCED FORCE OF DIAPHRAGM MUSCLE FIBERS IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION. ( 27190061 )
2016
46
Familial chronic thromboembolic pulmonary hypertension in aA mother and aA son: successful treatment with refined balloon pulmonary angioplasty. ( 28010001 )
2016
47
Pulmonary vascular morphology as an imaging biomarker in chronic thromboembolic pulmonary hypertension. ( 27162616 )
2016
48
The predictive value of echocardiography for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism in Korea. ( 27044855 )
2016
49
Familial Chronic Thromboembolic Pulmonary Hypertension. ( 27055719 )
2016
50
Thrombin-Activatable Fibrinolysis Inhibitor in Chronic Thromboembolic Pulmonary Hypertension. ( 27102961 )
2016

Variations for Chronic Thromboembolic Pulmonary Hypertension

Expression for Chronic Thromboembolic Pulmonary Hypertension

Search GEO for disease gene expression data for Chronic Thromboembolic Pulmonary Hypertension.

Pathways for Chronic Thromboembolic Pulmonary Hypertension

Pathways related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.03 FGA FGB
2 10.95 FGA FGB
3 10.94 CPB2 FGA FGB
4
Show member pathways
10.63 CRP EDN1
5 10.3 BMPR2 NPPB

GO Terms for Chronic Thromboembolic Pulmonary Hypertension

Cellular components related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 CPB2 CRP EDN1 FGA FGB NPPB
2 platelet alpha granule lumen GO:0031093 9.37 FGA FGB
3 extracellular vesicle GO:1903561 9.32 FGA FGB
4 platelet alpha granule GO:0031091 9.26 FGA FGB
5 extracellular space GO:0005615 9.17 BMPR2 CPB2 CRP EDN1 FGA FGB
6 fibrinogen complex GO:0005577 8.96 FGA FGB

Biological processes related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.73 CPB2 FGA FGB
2 cellular response to interleukin-1 GO:0071347 9.64 EDN1 FGB
3 regulation of blood pressure GO:0008217 9.63 EDN1 NPPB
4 response to drug GO:0042493 9.63 CPB2 EDN1
5 positive regulation of endothelial cell migration GO:0010595 9.62 BMPR2 EDN1
6 toll-like receptor signaling pathway GO:0002224 9.62 FGA FGB
7 platelet aggregation GO:0070527 9.61 FGA FGB
8 positive regulation of protein secretion GO:0050714 9.61 FGA FGB
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.6 FGA FGB
10 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.59 FGA FGB
11 positive regulation of vasoconstriction GO:0045907 9.58 FGA FGB
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 FGA FGB
13 positive regulation of exocytosis GO:0045921 9.57 FGA FGB
14 cellular protein complex assembly GO:0043623 9.55 FGA FGB
15 regulation of blood vessel size GO:0050880 9.54 EDN1 NPPB
16 positive regulation of renal sodium excretion GO:0035815 9.52 EDN1 NPPB
17 positive regulation of urine volume GO:0035810 9.51 EDN1 NPPB
18 protein polymerization GO:0051258 9.49 FGA FGB
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 FGA FGB
20 plasminogen activation GO:0031639 9.46 FGA FGB
21 body fluid secretion GO:0007589 9.43 EDN1 NPPB
22 positive regulation of peptide hormone secretion GO:0090277 9.4 FGA FGB
23 induction of bacterial agglutination GO:0043152 9.32 FGA FGB
24 blood coagulation, fibrin clot formation GO:0072378 9.26 FGA FGB
25 response to calcium ion GO:0051592 9.16 FGA FGB
26 hemostasis GO:0007599 9.13 CPB2 FGA FGB
27 negative regulation of systemic arterial blood pressure GO:0003085 9.07 BMPR2
28 fibrinolysis GO:0042730 8.8 CPB2 FGA FGB

Molecular functions related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 9.16 FGA FGB
2 cell adhesion molecule binding GO:0050839 8.96 FGA FGB
3 receptor binding GO:0005102 8.92 EDN1 FGA FGB NPPB

Sources for Chronic Thromboembolic Pulmonary Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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