Aliases & Classifications for Chronic Tic Disorder

MalaCards integrated aliases for Chronic Tic Disorder:

Name: Chronic Tic Disorder 12 14
Chronic Motor or Vocal Tic Disorder 12 69
Tic Disorders 42
Tic Disorder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10600
ICD10 33 F95.1 F95 F95.9
ICD9CM 35 307.22
MeSH 42 D013981
NCIt 47 C116768
SNOMED-CT 64 192623005
UMLS 69 C0008701

Summaries for Chronic Tic Disorder

Disease Ontology : 12 A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.

MalaCards based summary : Chronic Tic Disorder, also known as chronic motor or vocal tic disorder, is related to tic disorder and cytoplasmic body myopathy, and has symptoms including symptoms and recurrent muscle twitches (symptom). An important gene associated with Chronic Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Allograft rejection and Immune response Fc epsilon RI pathway. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include brain, colon and heart, and related phenotype is homeostasis/metabolism.

Related Diseases for Chronic Tic Disorder

Diseases related to Chronic Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 tic disorder 10.5
2 cytoplasmic body myopathy 10.4 IL13 IL5
3 aortic arch interruption 10.4 IL13 IL5
4 hypercementosis 10.4 IL13 IL5
5 toxic diffuse goiter 10.4 IL13 IL5
6 cholesteatoma of middle ear 10.3 IL13 IL5
7 sideroblastic anemia 10.3 CSF2 IL5
8 myofibroma 10.3 IL13 IL5
9 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 10.3 IL13 IL5
10 esophagus small cell carcinoma 10.2 IL13 IL5
11 contact dermatitis 10.2 DRD4 OFCC1
12 goat milk allergy 10.2 IL13 IL4
13 hypertrophy of breast 10.2 DRD4 HTR7
14 marasmus 10.2 IL4 IL5
15 obsessive-compulsive disorder 10.2
16 lymphocytic gastritis 10.2 CSF2 IL5
17 orbit alveolar rhabdomyosarcoma 10.1 IL4 IL5
18 angioid streaks of choroid 10.1 IL4 IL5
19 cow milk allergy 10.1 IL13 IL4
20 x-linked intellectual disability, van esch type 10.1 IL4 IL5
21 urethral intrinsic sphincter deficiency 10.1 IL4 IL5
22 orbital plasma cell granuloma 10.1 IL4 IL5
23 apple allergy 10.1 IL4 IL5
24 myofascial pain syndrome 10.1 IL13 IL5
25 attention deficit-hyperactivity disorder 10.0
26 gilles de la tourette syndrome 10.0
27 female urethral cancer 10.0 IL4 IL5
28 autoimmune neuropathy 10.0 IL13 IL5
29 frontal sinus schneiderian papilloma 10.0 IL13 IL5
30 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.0 IL4 IL5
31 fibrous histiocytoma 10.0 IL4 IL5
32 exudative vitreoretinopathy 2, x-linked 9.9 CSF2 IL13 IL5
33 endocardium cancer 9.9 CSF2 IL13 IL5
34 philophthalmiasis 9.9 IL4 IL5
35 allescheriosis 9.9 CTSB IL4 IL5
36 histoplasmosis retinitis 9.9 CTSB IL4 IL5
37 18p deletion syndrome 9.9 CSF2 IL13 IL5
38 dioctophymiasis 9.9 IL13 IL4 IL5
39 winchester syndrome 9.9 IL13 IL4 IL5
40 cherry allergy 9.9 IL13 IL4 IL5
41 epididymis adenocarcinoma 9.9 IL13 IL4 IL5
42 purpura fulminans 9.9 IL13 IL4 IL5
43 fungal gastritis 9.9 IL13 IL4 IL5
44 abdominal tuberculosis 9.8 IL13 IL4 IL5
45 acute gonococcal prostatitis 9.8 IL13 IL4 IL5
46 trachea leiomyoma 9.8 IL13 IL4 IL5
47 viljoen kallis voges syndrome 9.8 IL13 IL4 IL5
48 angiomyoma 9.8 IL13 IL4 IL5
49 spindle cell variant squamous cell breast carcinoma 9.8 IL13 IL4 IL5
50 loiasis 9.8 IL13 IL4 IL5

Graphical network of the top 20 diseases related to Chronic Tic Disorder:



Diseases related to Chronic Tic Disorder

Symptoms & Phenotypes for Chronic Tic Disorder

UMLS symptoms related to Chronic Tic Disorder:


symptoms, recurrent muscle twitches (symptom)

MGI Mouse Phenotypes related to Chronic Tic Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.36 CSF2 CTSB DRD4 F12 HTR7 IL13

Drugs & Therapeutics for Chronic Tic Disorder

Drugs for Chronic Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4 58-22-0 6013
3
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
4
Budesonide Approved Phase 4 51333-22-3 63006 5281004
5 Anabolic Agents Phase 4
6 Androgens Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Hormone Antagonists Phase 4
9 Hormones Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
11 Pharmaceutical Solutions Phase 4,Phase 3
12 Testosterone 17 beta-cypionate Phase 4
13
Testosterone enanthate Phase 4 315-37-7 9416
14 Testosterone undecanoate Phase 4
15 Neurotransmitter Agents Phase 4,Phase 3
16 Peripheral Nervous System Agents Phase 4,Phase 3
17 Cholinergic Agents Phase 4
18 Antipsychotic Agents Phase 4,Phase 3
19 Central Nervous System Depressants Phase 4,Phase 3
20 Psychotropic Drugs Phase 4,Phase 3
21 Tranquilizing Agents Phase 4,Phase 3
22 Adrenergic Agents Phase 4,Phase 3
23 Adrenergic Agonists Phase 4,Phase 3
24 Adrenergic beta-2 Receptor Agonists Phase 4
25 Adrenergic beta-Agonists Phase 4
26 Anti-Asthmatic Agents Phase 4
27 Anti-Inflammatory Agents Phase 4
28 Autonomic Agents Phase 4
29 Bronchodilator Agents Phase 4
30 Formoterol Fumarate Phase 4
31 glucocorticoids Phase 4
32 Respiratory System Agents Phase 4,Phase 2
33 Bromides Phase 4
34 Cholinergic Antagonists Phase 4
35 Parasympatholytics Phase 4
36 Tiotropium Bromide Phase 4 136310-93-5
37
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
38
Guanfacine Approved, Investigational Phase 3 29110-47-2 3519
39
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
40
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
41
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
42
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
43
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078 2978
44 Dopamine Agents Phase 3
45 Dopamine Antagonists Phase 3
46 Tiapride Hydrochloride Phase 3
47 Adrenergic alpha-2 Receptor Agonists Phase 3
48 Adrenergic alpha-Agonists Phase 3
49 Antihypertensive Agents Phase 3
50 Adjuvants, Anesthesia Phase 3

Interventional clinical trials:

(show all 44)

id Name Status NCT ID Phase Drugs
1 Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects Unknown status NCT01813201 Phase 4 Testosterone undecanoate;Saline isotonic solution
2 Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT00241176 Phase 4 Aripiprazole
3 Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD Completed NCT03028701 Phase 4 Formoterol/Budesonide 12/400 mcg Discair
4 Comparison 24 Hour Bronchodilator Efficacy of Tiotropium 18 mcg Delivered Via DISCAIR Versus SPIRIVA 18 µg Delivered Via HANDIHALER® in Patients With Moderate to Severe COPD Completed NCT02541006 Phase 4 Tiotropium 18 mcg
5 Tiotropium/Formoterol Via Discair® vs Tiotropium Monotherapy or Tiotropium + Formoterol Free Combination Treatment Recruiting NCT02988869 Phase 4 Tiotropium/Formoterol;Tiotropium;Formoterol;Tiotropium
6 Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Completed NCT00706589 Phase 3 aripiprazole;placebo
7 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
8 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3 5LGr;tiapride;placebo
9 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder Completed NCT00004376 Phase 3 guanfacine
10 Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery Completed NCT01837290 Phase 3 dexmedetomidine infusion for premedication;Midazolam;saline infusion;Spinal block with hyperbaric bupivacaine 0.5% 12.5 mg
11 Integral Clinical Plan Shared With or Without Telemonitoring of Constants in Patient With Chronic Diseases Recruiting NCT03018717 Phase 3
12 CANNAbinoids in the Treatment of TICS (CANNA-TICS) Not yet recruiting NCT03087201 Phase 3 nabiximols;placebo
13 Effectiveness of Behavior Therapy and Psychosocial Therapy for the Treatment of Tourette Syndrome and Chronic Tic Disorder Completed NCT00231985 Phase 2
14 VoIP Delivered Behavior Therapy for Tourette Syndrome Completed NCT02247206 Phase 2
15 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2 N-Acetylcysteine (NAC);Placebo
16 Subthalamic Stimulation in Tourette's Syndrome Completed NCT02619084 Phase 2
17 Developing Cognitive Training for Tourette Syndrome Completed NCT01440023 Phase 1
18 A Study to Evaluate the Effects of ABX-1431 on Patients With Tourette Syndrome Recruiting NCT03058562 Phase 1 ABX-1431;Placebo Comparator;ABX-1431
19 Pilot Study for Use of Dysport in Treatment of Vocal Tics in Patients With Tourette's Syndrome Unknown status NCT02187679 Abobotulinum toxin A
20 Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder Completed NCT00081419
21 A Naturalistic Study Investigating Sleep and Cognitive Learning in Children With and Without Tic Disorders Completed NCT02676492
22 Brain Activation in Vocal and Motor Tics Completed NCT00026000
23 Neurocognitive Correlates of Behavioral Treatment for Childhood Tic Disorders Completed NCT00675675
24 Anger Control Training for Youth With Tourette Syndrome Completed NCT00486551
25 Study of Tics in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder Completed NCT00033995
26 Brain Dynamics Involved in Generating Tics and Controlling Voluntary Movement Completed NCT00056420
27 Study of the Neurobiology of Tourette Syndrome and Related Disorders Completed NCT00004325
28 Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo Recruiting NCT02582515 D-cycloserine;Placebo
29 Assessment of Children With Tic Onset in the Past 6 Months Recruiting NCT01177774
30 Neurofeedback for Tourette Syndrome Recruiting NCT01702077
31 Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders Recruiting NCT02605902
32 Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus Recruiting NCT01860300 Amoxicillin-Potassium Clavulanate Combination;placebo
33 Modified Comprehensive Behavioral Intervention for Tics (M_CBIT) Recruiting NCT02900144
34 TicHelper: A Computerized Comprehensive Behavioral Intervention for Tics (CBIT) Recruiting NCT02413216
35 Brain-Behavior Interactions in Tic Suppression Recruiting NCT02205918
36 Evaluation of a Cognitive Psychophysiological Treatment for Tourette Syndrome and Tic Disorders Recruiting NCT03225430
37 pCO2 Oscillations During Exercise: Relation to Cerebral Blood Flow and to Cognitive Dysfunction in COPD Recruiting NCT02660437
38 Behavioral Therapy for Tourette Syndrome Recruiting NCT03019731
39 Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome Active, not recruiting NCT02067819
40 Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder Active, not recruiting NCT02864589
41 Dissemination of Comprehensive Behavioral Intervention for Tics (CBIT) to Occupational Therapists: A Feasibility Study Active, not recruiting NCT02114905
42 Psychosocial Intervention for Young Children With Chronic Tics Active, not recruiting NCT03042507
43 Group Intervention for Children With Chronic Tics Syndrome or Tourette Syndrome: CBIT vs Psycho-Educational Intervention Not yet recruiting NCT02407951
44 Aripiprazole in the Treatment of Tourette's Syndrome Terminated NCT00282139 Aripiprazole

Search NIH Clinical Center for Chronic Tic Disorder

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: tic disorders

Genetic Tests for Chronic Tic Disorder

Anatomical Context for Chronic Tic Disorder

MalaCards organs/tissues related to Chronic Tic Disorder:

39
Brain, Colon, Heart, Skin, B Cells

Publications for Chronic Tic Disorder

Articles related to Chronic Tic Disorder:

(show all 36)
id Title Authors Year
1
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
2
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
3
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
4
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
5
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review. ( 26880181 )
2016
6
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
7
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
8
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
9
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
10
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
11
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
12
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
13
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
14
Evidence-based assessment of compulsive skin picking, chronic tic disorders and trichotillomania in children. ( 22488574 )
2012
15
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
16
A proper name for chronic tic disorder. ( 20889671 )
2010
17
Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. ( 19864199 )
2009
18
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. ( 19698938 )
2009
19
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. ( 17717739 )
2008
20
Cognitive-behaviour therapy and skilled motor performance in adults with chronic tic disorder. ( 18058387 )
2008
21
Obsessive-compulsive disorder in youth with and without a chronic tic disorder. ( 17345600 )
2008
22
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. ( 18439116 )
2008
23
Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects. ( 17171537 )
2007
24
Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder. ( 17453897 )
2007
25
Quality of life in youth with Tourette's syndrome and chronic tic disorder. ( 17484694 )
2007
26
Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder. ( 17052389 )
2006
27
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate. ( 16536367 )
2006
28
Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. ( 15368493 )
2004
29
A computer-aided diagnosis for distinguishing Tourette's syndrome from chronic tic disorder in children by a fuzzy system with a two-step minimization approach. ( 15248548 )
2004
30
A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. ( 12090818 )
2002
31
Differences in 99mTc-HMPAO brain SPET perfusion imaging between Tourette's syndrome and chronic tic disorder in children. ( 11303888 )
2001
32
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. ( 11694329 )
2001
33
A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified. ( 8973076 )
1996
34
Associated psychopathology in children with both ADHD and chronic tic disorder. ( 8973069 )
1996
35
Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. ( 8038934 )
1994
36
The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. ( 8227493 )
1993

Variations for Chronic Tic Disorder

Expression for Chronic Tic Disorder

Search GEO for disease gene expression data for Chronic Tic Disorder.

Pathways for Chronic Tic Disorder

Pathways related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 CTSB IL13 IL4 IL5
2
Show member pathways
12.38 CSF2 IL13 IL4 IL5
3
Show member pathways
12.13 CSF2 IL13 IL4 IL5
4
Show member pathways
11.97 CSF2 IL13 IL4 IL5
5
Show member pathways
11.95 IL13 IL4 IL5
6 11.8 CSF2 IL4 IL5
7 11.7 CSF2 IL4 IL5
8 11.6 IL13 IL4 IL5
9
Show member pathways
11.57 CSF2 IL4 IL5
10 11.47 CSF2 IL13 IL4 IL5
11 11.32 CSF2 IL13 IL4
12 11.26 CSF2 IL13 IL4 IL5
13 11.25 IL13 IL4 IL5
14 11.09 IL4 IL5
15 11.05 IL13 IL4 IL5
16 11.01 CSF2 IL13 IL4 IL5
17 10.91 IL13 IL4 IL5
18 10.4 CSF2 IL13 IL4 IL5
19 10.31 IL13 IL4 IL5

GO Terms for Chronic Tic Disorder

Biological processes related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 CSF2 IL13 IL4 IL5
2 B cell activation GO:0042113 9.51 AKAP17A IL4
3 negative regulation of endothelial cell apoptotic process GO:2000352 9.49 IL13 IL4
4 myeloid dendritic cell differentiation GO:0043011 9.48 CSF2 IL4
5 microglial cell activation GO:0001774 9.46 IL13 IL4
6 dendritic cell differentiation GO:0097028 9.43 CSF2 IL4
7 positive regulation of podosome assembly GO:0071803 9.4 CSF2 IL5
8 positive regulation of mast cell degranulation GO:0043306 9.37 IL13 IL4
9 positive regulation of immunoglobulin production GO:0002639 9.32 IL13 IL4
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 CSF2 IL4
11 regulation of proton transport GO:0010155 9.16 IL13 IL4
12 positive regulation of B cell proliferation GO:0030890 9.13 IL13 IL4 IL5
13 negative regulation of complement-dependent cytotoxicity GO:1903660 8.62 IL13 IL4

Molecular functions related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 AKAP17A CSF2 CTSB DNAJC13 DRD4 F12
2 growth factor activity GO:0008083 9.33 CSF2 IL4 IL5
3 cytokine receptor binding GO:0005126 9.26 IL13 IL4
4 cytokine activity GO:0005125 8.92 CSF2 IL13 IL4 IL5

Sources for Chronic Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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