Aliases & Classifications for Chronic Tic Disorder

MalaCards integrated aliases for Chronic Tic Disorder:

Name: Chronic Tic Disorder 12 14
Chronic Motor or Vocal Tic Disorder 12 69
Tic Disorders 41
Tic Disorder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10600
ICD10 32 F95.1 F95 F95.9
ICD9CM 34 307.22
MeSH 41 D013981
NCIt 46 C116768
SNOMED-CT 64 192623005
UMLS 69 C0008701

Summaries for Chronic Tic Disorder

Disease Ontology : 12 A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.

MalaCards based summary : Chronic Tic Disorder, also known as chronic motor or vocal tic disorder, is related to tic disorder and transient tic disorder, and has symptoms including recurrent muscle twitches (symptom) and symptoms. An important gene associated with Chronic Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Allograft rejection and Immune response Fc epsilon RI pathway. The drugs Aripiprazole and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, colon and b cells, and related phenotype is homeostasis/metabolism.

Related Diseases for Chronic Tic Disorder

Diseases related to Chronic Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 tic disorder 31.0 DRD4 OFCC1
2 transient tic disorder 12.5
3 gilles de la tourette syndrome 10.3
4 cytokine deficiency 10.3 IL13 IL5
5 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL13 IL5
6 respiratory syncytial virus infectious disease 10.2 IL13 IL5
7 obsessive-compulsive disorder 10.2
8 paragonimiasis 10.2 IL13 IL5
9 strongyloidiasis 10.2 IL13 IL5
10 seborrheic infantile dermatitis 10.2 CSF2 IL5
11 nut allergy 10.2 IL13 IL5
12 penicillin allergy 10.1 IL13 IL4
13 radiation cystitis 10.1 IL13 IL5
14 separation anxiety disorder 10.1 DRD4 HTR7
15 attention deficit-hyperactivity disorder 10.1
16 eosinophilic gastroenteritis 10.1 CSF2 IL5
17 cough variant asthma 10.1 IL4 IL5
18 egg allergy 10.1 IL4 IL5
19 trichinosis 10.0 IL4 IL5
20 atopic keratoconjunctivitis 10.0 IL4 IL5
21 beta-lactam allergy 10.0 IL13 IL4
22 scleritis 10.0 IL4 IL5
23 intrinsic asthma 10.0 IL4 IL5
24 radiculopathy 10.0 IL13 IL5
25 gastrointestinal allergy 10.0 IL4 IL5
26 kimura disease 10.0 IL4 IL5
27 folliculitis 9.9 IL4 IL5
28 pollen allergy 9.9 IL13 IL5
29 toxic oil syndrome 9.9 IL4 IL5
30 night blindness, congenital stationary, type 1a 9.9 CSF2 IL13 IL5
31 eosinophilic pneumonia 9.9 CSF2 IL13 IL5
32 primary amebic meningoencephalitis 9.9 IL4 IL5
33 non-suppurative otitis media 9.9 CTSB IL4 IL5
34 cercarial dermatitis 9.9 CTSB IL4 IL5
35 hypereosinophilic syndrome 9.9 CSF2 IL13 IL5
36 angiostrongyliasis 9.8 IL13 IL4 IL5
37 inflammatory bowel disease 4 9.8 IL13 IL4 IL5
38 apple allergy 9.8 IL13 IL4 IL5
39 latex allergy 9.8 IL13 IL4 IL5
40 eosinophilic meningitis 9.8 IL13 IL4 IL5
41 intestinal schistosomiasis 9.8 IL13 IL4 IL5
42 urinary schistosomiasis 9.8 IL13 IL4 IL5
43 chronic conjunctivitis 9.8 IL13 IL4 IL5
44 eosinophilic gastritis 9.8 IL13 IL4 IL5
45 vernal keratoconjunctivitis 9.8 IL13 IL4 IL5
46 conjunctival disease 9.8 IL13 IL4 IL5
47 enterobiasis 9.8 IL13 IL4 IL5
48 paranasal sinus disease 9.8 IL13 IL4 IL5
49 onchocerciasis 9.8 IL13 IL4 IL5
50 allergic conjunctivitis 9.8 IL13 IL4 IL5

Graphical network of the top 20 diseases related to Chronic Tic Disorder:



Diseases related to Chronic Tic Disorder

Symptoms & Phenotypes for Chronic Tic Disorder

UMLS symptoms related to Chronic Tic Disorder:


recurrent muscle twitches (symptom), symptoms

MGI Mouse Phenotypes related to Chronic Tic Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.36 CSF2 CTSB DRD4 F12 HTR7 IL13

Drugs & Therapeutics for Chronic Tic Disorder

Drugs for Chronic Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 3 129722-12-9 60795
2
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
3
Guanfacine Approved, Investigational Phase 3 29110-47-2 3519
4
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078 2978
5 Neurotransmitter Agents Phase 3
6 Antipsychotic Agents Phase 3
7 Central Nervous System Depressants Phase 3
8 Psychotropic Drugs Phase 3
9 Tranquilizing Agents Phase 3
10 Dopamine Agents Phase 3
11 Dopamine Antagonists Phase 3
12 Tiapride Hydrochloride Phase 3
13 Adrenergic Agents Phase 3
14 Adrenergic Agonists Phase 3
15 Adrenergic alpha-2 Receptor Agonists Phase 3
16 Adrenergic alpha-Agonists Phase 3
17 Antihypertensive Agents Phase 3
18
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
19 Antidotes Phase 2
20 Anti-Infective Agents Phase 2
21 Antioxidants Phase 2
22 Antiviral Agents Phase 2
23 Expectorants Phase 2
24 N-monoacetylcystine Phase 2
25 Protective Agents Phase 2
26 Respiratory System Agents Phase 2
27
Acetylcholine Approved 51-84-3 187
28
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
29
Sulfamethazine Approved, Investigational, Vet_approved 57-68-1 5327
30
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
31
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
32
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
33
Cycloserine Approved 68-41-7 6234 401
34
Menthol Approved 2216-51-5 16666
35 tannic acid Approved, Nutraceutical
36 abobotulinumtoxinA
37 Botulinum Toxins
38 Botulinum Toxins, Type A
39 Cholinergic Agents
40 Neuromuscular Agents
41 onabotulinumtoxinA
42 Peripheral Nervous System Agents
43 Amoxicillin-Potassium Clavulanate Combination
44 Anti-Bacterial Agents
45 Antibiotics, Antitubercular
46 beta-Lactamase Inhibitors
47 Clavulanic Acid
48 Antifungal Agents
49 Dermatologic Agents
50 Keratolytic Agents

Interventional clinical trials:

(show all 27)

# Name Status NCT ID Phase Drugs
1 Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Completed NCT00706589 Phase 3 aripiprazole;placebo
2 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
3 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3 5LGr;tiapride;placebo
4 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder Completed NCT00004376 Phase 3 guanfacine
5 CANNAbinoids in the Treatment of TICS (CANNA-TICS) Not yet recruiting NCT03087201 Phase 3 nabiximols;placebo
6 Effectiveness of Behavior Therapy and Psychosocial Therapy for the Treatment of Tourette Syndrome and Chronic Tic Disorder Completed NCT00231985 Phase 2
7 VoIP Delivered Behavior Therapy for Tourette Syndrome Completed NCT02247206 Phase 2
8 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2 N-Acetylcysteine (NAC);Placebo
9 Developing Cognitive Training for Tourette Syndrome Completed NCT01440023 Phase 1
10 Pilot Study for Use of Dysport in Treatment of Vocal Tics in Patients With Tourette's Syndrome Unknown status NCT02187679 Abobotulinum toxin A
11 Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder Completed NCT00081419
12 A Naturalistic Study Investigating Sleep and Cognitive Learning in Children With and Without Tic Disorders Completed NCT02676492
13 Brain Activation in Vocal and Motor Tics Completed NCT00026000
14 Neurocognitive Correlates of Behavioral Treatment for Childhood Tic Disorders Completed NCT00675675
15 Anger Control Training for Youth With Tourette Syndrome Completed NCT00486551
16 TicHelper: A Computerized Comprehensive Behavioral Intervention for Tics (CBIT) Completed NCT02413216
17 Assessment of Children With Tic Onset in the Past 6 Months Recruiting NCT01177774
18 Neurofeedback for Tourette Syndrome Recruiting NCT01702077
19 Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders Recruiting NCT02605902
20 Modified Comprehensive Behavioral Intervention for Tics (M_CBIT) Recruiting NCT02900144
21 Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus Recruiting NCT01860300 Amoxicillin-Potassium Clavulanate Combination;placebo
22 Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome Active, not recruiting NCT02067819
23 Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder Active, not recruiting NCT02864589
24 Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo Active, not recruiting NCT02582515 D-cycloserine;Placebo
25 Dissemination of Comprehensive Behavioral Intervention for Tics (CBIT) to Occupational Therapists: A Feasibility Study Active, not recruiting NCT02114905
26 Psychosocial Intervention for Young Children With Chronic Tics Active, not recruiting NCT03042507
27 Aripiprazole in the Treatment of Tourette's Syndrome Terminated NCT00282139 Aripiprazole

Search NIH Clinical Center for Chronic Tic Disorder

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: tic disorders

Genetic Tests for Chronic Tic Disorder

Anatomical Context for Chronic Tic Disorder

MalaCards organs/tissues related to Chronic Tic Disorder:

38
Brain, Colon, B Cells, Skin

Publications for Chronic Tic Disorder

Articles related to Chronic Tic Disorder:

(show all 36)
# Title Authors Year
1
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
2
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
3
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
4
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
5
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review. ( 26880181 )
2016
6
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
7
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
8
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
9
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
10
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
11
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
12
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
13
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
14
Evidence-based assessment of compulsive skin picking, chronic tic disorders and trichotillomania in children. ( 22488574 )
2012
15
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
16
A proper name for chronic tic disorder. ( 20889671 )
2010
17
Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. ( 19864199 )
2009
18
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. ( 19698938 )
2009
19
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. ( 18439116 )
2008
20
Obsessive-compulsive disorder in youth with and without a chronic tic disorder. ( 17345600 )
2008
21
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. ( 17717739 )
2008
22
Cognitive-behaviour therapy and skilled motor performance in adults with chronic tic disorder. ( 18058387 )
2008
23
Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder. ( 17453897 )
2007
24
Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects. ( 17171537 )
2007
25
Quality of life in youth with Tourette's syndrome and chronic tic disorder. ( 17484694 )
2007
26
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate. ( 16536367 )
2006
27
Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder. ( 17052389 )
2006
28
Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. ( 15368493 )
2004
29
A computer-aided diagnosis for distinguishing Tourette's syndrome from chronic tic disorder in children by a fuzzy system with a two-step minimization approach. ( 15248548 )
2004
30
A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. ( 12090818 )
2002
31
Differences in 99mTc-HMPAO brain SPET perfusion imaging between Tourette's syndrome and chronic tic disorder in children. ( 11303888 )
2001
32
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. ( 11694329 )
2001
33
A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified. ( 8973076 )
1996
34
Associated psychopathology in children with both ADHD and chronic tic disorder. ( 8973069 )
1996
35
Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. ( 8038934 )
1994
36
The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. ( 8227493 )
1993

Variations for Chronic Tic Disorder

Expression for Chronic Tic Disorder

Search GEO for disease gene expression data for Chronic Tic Disorder.

Pathways for Chronic Tic Disorder

Pathways related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 CTSB IL13 IL4 IL5
2
Show member pathways
12.38 CSF2 IL13 IL4 IL5
3
Show member pathways
12.13 CSF2 IL13 IL4 IL5
4
Show member pathways
12.11 CSF2 IL13 IL4 IL5
5
Show member pathways
11.95 IL13 IL4 IL5
6 11.8 CSF2 IL4 IL5
7 11.7 CSF2 IL4 IL5
8 11.6 IL13 IL4 IL5
9
Show member pathways
11.57 CSF2 IL4 IL5
10 11.47 CSF2 IL13 IL4 IL5
11 11.32 CSF2 IL13 IL4
12 11.26 CSF2 IL13 IL4 IL5
13 11.24 IL13 IL4 IL5
14 11.09 IL4 IL5
15 11.05 IL13 IL4 IL5
16 11.01 CSF2 IL13 IL4 IL5
17 10.91 IL13 IL4 IL5
18 10.4 CSF2 IL13 IL4 IL5
19 10.21 IL13 IL4 IL5

GO Terms for Chronic Tic Disorder

Biological processes related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 CSF2 IL13 IL4 IL5
2 regulation of receptor activity GO:0010469 9.67 CSF2 IL13 IL4 IL5
3 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 IL13 IL4
4 B cell activation GO:0042113 9.4 AKAP17A IL4
5 myeloid dendritic cell differentiation GO:0043011 9.32 CSF2 IL4
6 positive regulation of podosome assembly GO:0071803 9.26 CSF2 IL5
7 dendritic cell differentiation GO:0097028 9.16 CSF2 IL4
8 positive regulation of B cell proliferation GO:0030890 9.13 IL13 IL4 IL5
9 negative regulation of complement-dependent cytotoxicity GO:1903660 8.62 IL13 IL4

Molecular functions related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 AKAP17A CSF2 CTSB DNAJC13 DRD4 F12
2 growth factor activity GO:0008083 9.33 CSF2 IL4 IL5
3 cytokine receptor binding GO:0005126 9.26 IL13 IL4
4 cytokine activity GO:0005125 8.92 CSF2 IL13 IL4 IL5

Sources for Chronic Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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