MCID: CHR415
MIFTS: 33

Chronic Venous Leg Ulcers malady

Summaries for Chronic Venous Leg Ulcers

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33MalaCards
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MalaCards: Chronic Venous Leg Ulcers, also known as chronic ulcer of lower extremity, is related to thrombophilia and venous insufficiency. An important gene associated with Chronic Venous Leg Ulcers is NFKBIL1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1), and among its related pathways are Rheumatoid arthritis and Alpha-defensins. The compounds pge2 and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Chronic Venous Leg Ulcers

Sources:
31LifeMap Discovery™, 45Novoseek, 61UMLS
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Aliases & Descriptions:

chronic venous leg ulcers 31 45
chronic ulcer of lower extremity 61


Related Diseases for Chronic Venous Leg Ulcers

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia10.4
2venous insufficiency10.4
3reflex sympathetic dystrophy10.2
4atopic dermatitis10.2
5hemochromatosis10.2
6chronic pain10.2
7hepatitis c10.0TGIF1
8gingivitis10.0TIMP1
9pulmonary disease, chronic obstructive10.0TIMP1
10peritonitis10.0ITGB2
11lichen planus10.0ITGB2
12crohn's disease10.0ITGA4
13thyroiditis10.0FASLG
14multiple myeloma10.0ITGA4
15adenoma10.0TGFBR2
16moyamoya disease10.0TGIF1
17meningioma10.0TGIF1
18dermatitis10.0ITGB2
19dilated cardiomyopathy10.0BSG
20acute myocardial infarction10.0ITGB2
21gastric ulcer10.0FGF7
22sjogren's syndrome10.0FASLG
23tuberculosis10.0DEFA1, ITGB2
24liver cirrhosis10.0TIMP1
25duodenal ulcer10.0TGIF1, LTA
26hepatitis b10.0MMP3
27oral submucous fibrosis10.0TIMP1
28polycythemia10.0TIMP1
29aortic aneurysm10.0TGFBR2
30nephritis10.0LTA, ITGA4
31diabetes mellitus10.0MMP3, ITGB2
32pneumonia10.0ITGA4, FGF7
33seminoma10.0PDGFRA
34pituitary adenoma10.0TGFBR2
35myopia 610.0TGIF1
36lupus nephritis10.0LTA, ITGB2
37uveitis10.0LTA, ITGA4
38bronchopulmonary dysplasia10.0FGF7, TIMP1
39arteriosclerosis10.0TGIF1, PDGFRA
40sarcoidosis10.0LTA, TGIF1
41thromboembolism10.0TTF2
42retinoblastoma10.0TGFBR2, TGIF1
43laryngeal carcinoma10.0PLAU
44dementia10.0TTF2, MMP3
45galactosemia10.0TIMP1
46hepatitis10.0FASLG, LTA, TTF2
47laryngeal squamous cell carcinoma10.0TGFBR2, BSG
48cystic fibrosis10.0FGF7, DEFA1
49silicosis10.0FASLG
50gingival overgrowth10.0MMP3, FGF7, TIMP1

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to chronic venous leg ulcers

Clinical Features for Chronic Venous Leg Ulcers

Drugs & Therapeutics for Chronic Venous Leg Ulcers

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Venous Leg Ulcers

Drug clinical trials:

Search ClinicalTrials for Chronic Venous Leg Ulcers

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Search CenterWatch for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf, PMIDs: 12055943, 12463767, 20849380, 18615798

Genetic Tests for Chronic Venous Leg Ulcers

Anatomical Context for Chronic Venous Leg Ulcers

Sources:
33MalaCards
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MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

33
Skin

Animal Models for Chronic Venous Leg Ulcers or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Chronic Venous Leg Ulcers

Sources:
51PubMed
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Articles related to Chronic Venous Leg Ulcers:

idTitleAuthorsYear
1
Chronic venous leg ulcers benefit from surgery: long-term results from 173 legs. (16950436)
2006
2
Risk factors for delayed healing and recurrence of chronic venous leg ulcers--an analysis of 1324 legs. (15570275)
2005

Genetic Variations for Chronic Venous Leg Ulcers

Expression for genes affiliated with Chronic Venous Leg Ulcers

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Chronic Venous Leg Ulcers

Search GEO for disease gene expression data for Chronic Venous Leg Ulcers.

Pathways for genes affiliated with Chronic Venous Leg Ulcers

Sources:
30KEGG, 54Reactome, 52QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ITGB2, ATP6V1G2
210.2DEFA3, DEFA1
3
Hide members
10.1TIMP2, TIMP1, LTA
410.1PDGFRA, TIMP1, TIMP2
5
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10.1MMP3, TIMP1, TIMP2
610.1BSG, ITGA4, ITGB2
710.1ITGB2, ITGA4, FASLG
8
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10.1FGF7, ITGA4, PDGFRA
9
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10.1TGFBR2, FGF7, PDGFRA
1010.0PDGFRA, ITGB2, LTA, TGFBR2
11
Hide members
10.0TIMP2, TIMP1, BSG, MMP3
12
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10.0FASLG, ITGA4, ITGB2, LTA
13
Cell adhesion ECM remodeling
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10.0TIMP2, TIMP1, MMP3, PLAU
14
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10.0FGF7, ITGB2, ITGA4, PDGFRA
159.9DEFA3, MMP3, PLAU, TGFBR2
16
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9.9TGFBR2, FGF7, FASLG, PDGFRA
17
Hide members
9.7FGF7, TIMP2, TIMP1, ITGA4, ITGB2, LTA
18
Hide members
9.7TIMP2, TIMP1, PDGFRA, LTA, FGF7, TGFBR2
19
Hide members
9.6PDGFRA, ITGA4, ITGB2, DEFA3, DEFA1, FGF7
20
Hide members
9.6TIMP2, TIMP1, PDGFRA, ITGA4, ITGB2, LTA
21
Hide members
9.5TIMP2, TIMP1, PDGFRA, ITGA4, ITGB2, LTA
22
Hide members
9.5TIMP2, TIMP1, PDGFRA, ITGA4, ITGB2, LTA
23
Hide members
9.5TIMP2, TIMP1, PDGFRA, ITGA4, ITGB2, FGF7

Compounds for genes affiliated with Chronic Venous Leg Ulcers

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 50PharmGKB
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Compounds related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1pge24510.8PLAU
2indomethacin45 60 29 1113.6PLAU
3glutamate4510.6ITGB2, DEFA1
4estradiol45 11 2412.5PLAU, FASLG
5cycloheximide4510.5FGF7, FASLG, LTA
6propionate4510.3TIMP2, MMP3, PLAU, TIMP1
71,10-phenanthroline45 211.3FASLG, TIMP1, TIMP2, MMP3
8rantes4510.3FASLG, ITGA4, ITGB2, LTA, FGF7
9batimastat45 60 1112.3MMP3, TIMP1, PLAU, TIMP2
10latanoprost45 1111.2TIMP2, TIMP1, MMP3
11tamoxifen45 50 29 1113.2TGFBR2, TGIF1, FASLG, FGF7
12doxycycline45 1111.1PLAU, MMP3, FGF7, FASLG, TIMP1, TGIF1
13nimesulide45 1111.1MMP3, PLAU, TIMP1
14aspartate4510.1FASLG, FGF7, ITGA4, ITGB2, PDGFRA
15infliximab45 50 1112.1TIMP1, ITGA4, LTA, MMP3
16herbimycin a45 6011.1PLAU, ITGB2, TIMP1, TIMP2, LTA
17cytochalasin d45 6011.1MMP3, ITGB2, TGIF1, FASLG, ITGA4, TIMP2
18dexamethasone45 50 29 1113.1ITGA4, TGIF1, TIMP1, ITGB2, FASLG, TGFBR2
19ivig4510.1ITGB2
20nitric oxide45 11 2412.1TGFBR2, ITGB2, ITGA4, FASLG, TTF2, TIMP1
21cyclosporin a45 29 6012.0BSG, TIMP2, ITGB2, TTF2, TGFBR2, LTA
22sb 20358045 6011.0PLAU, FASLG, BSG, ITGB2, MMP3, TIMP2
23paraffin4510.0PLAU, MMP3, LTA, FASLG, PDGFRA, TIMP1
24ribonucleic acid4510.0TGFBR2, TIMP2, TIMP1, TGIF1, FGF7, MMP3
25matrigel4510.0PLAU, FGF7, TIMP2, MMP3, TIMP1, BSG
26serine4510.0TIMP1, TTF2, MMP3, FGF7, LTA, ITGA4
27ly2940024510.0PLAU, FASLG, BSG, TIMP2, TGFBR2, TIMP1
28glucose459.9TIMP2, DEFA1, TTF2, TGFBR2, FASLG, BSG
29vitamin d459.9TGFBR2, TIMP1, ITGB2, LTA, FGF7, TTF2
3012-o-tetradecanoylphorbol 13-acetate459.9LTA, MMP3, TGIF1, PLAU, ITGB2, TIMP1
31actinomycin d459.9TIMP2, TGFBR2, PLAU, FGF7, LTA, FASLG
32hyaluronic acid45 2410.9LTA, FASLG, TIMP1, ITGB2, PLAU, MMP3
33oxygen45 2410.9TTF2, ITGA4, FGF7, TIMP2
34pd 98,059459.8PLAU, MMP3, FGF7, FASLG, TIMP2, TIMP1
35lactate459.8TGIF1, PLAU, MMP3, ITGB2, BSG, FASLG
36h2o2459.8TIMP2, TIMP1, FASLG, LTA, FGF7, ITGB2
37tgf beta1459.8TIMP1, PDGFRA, FASLG, LTA, FGF7, MMP3
38oligonucleotide459.8TIMP2, PDGFRA, TGFBR2, TGIF1, FGF7, LTA
39adenylate459.8TIMP1, TGFBR2, PLAU, ITGB2, TIMP2, FGF7
40genistein45 29 60 2 11 2414.8ITGB2, TGIF1, PLAU, MMP3, ITGA4, FASLG
41cholesterol45 29 11 2412.8FASLG, TGIF1, TGFBR2, BSG, TIMP1, ITGB2
42alanine459.7TGFBR2, ITGB2, MMP3, TTF2, PLAU, FASLG
43heparin45 29 11 2412.7FGF7, TGIF1, TTF2, TIMP2, TIMP1, FASLG
44wortmannin459.7FASLG, PLAU, ITGA4, ITGB2, FGF7, TGFBR2
45cysteine459.6TGIF1, PLAU, FGF7, ITGB2, TTF2, FASLG
46progesterone45 60 29 11 2413.6BSG, TGFBR2, TGIF1, FASLG, PLAU, TTF2
47tyrosine459.5LTA, ITGA4, BSG, FASLG, PDGFRA, TIMP1
48retinoic acid45 2410.4LTA, TGFBR2, TGIF1, TIMP2, TIMP1, PDGFRA
49vegf459.4TIMP2, FASLG, BSG, ITGB2, LTA, FGF7
50calcium45 50 11 2412.3FASLG, PDGFRA, TGFBR2, ITGB2, TGIF1, TTF2

GO Terms for genes affiliated with Chronic Venous Leg Ulcers

Sources:
16Gene Ontology
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Cellular components related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9TGFBR2, ITGA4, FASLG, PDGFRA
2extracellular regionGO:0055769.5TIMP1, FASLG, DEFA3, FGF7, MMP3, PLAU
3extracellular spaceGO:0056159.4TIMP2, FASLG, DEFA3, LTA, MMP3, PLAU

Biological processes related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:02261710.1TIMP1, MMP3, TIMP2
2agingGO:00756810.1TIMP2, TIMP1, TGFBR2
3positive regulation of cell proliferationGO:0082849.9TIMP1, PDGFRA, FASLG, FGF7, TGFBR2
4blood coagulationGO:0075969.9ITGA4, BSG, TIMP1, ITGB2, PLAU
5extracellular matrix organizationGO:0301989.9MMP3, PDGFRA, TIMP1, TIMP2
6response to drugGO:0424939.7LTA, TGIF1, TGFBR2, TIMP2

Molecular functions related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:00819110.2TIMP1, TIMP2

Products for genes affiliated with Chronic Venous Leg Ulcers

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Venous Leg Ulcers

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet