Aliases & Classifications for Chronic Venous Leg Ulcers

MalaCards integrated aliases for Chronic Venous Leg Ulcers:

Name: Chronic Venous Leg Ulcers 37 51

Summaries for Chronic Venous Leg Ulcers

MalaCards based summary : Chronic Venous Leg Ulcers is related to chronic venous insufficiency and venous insufficiency. An important gene associated with Chronic Venous Leg Ulcers is TIMP1 (TIMP Metallopeptidase Inhibitor 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Carboxymethylcellulose Sodium and Cathartics have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil, and related phenotypes are Decreased Salmonella-containing vacuole maturation and cardiovascular system

Related Diseases for Chronic Venous Leg Ulcers

Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 30.3 ITGA4 TIMP1
2 venous insufficiency 30.3 ITGA4 TIMP1
3 squamous cell carcinoma of the hypopharynx 10.1 MMP9 TIMP1
4 cryptogenic organizing pneumonia 10.1 MMP9 TIMP1
5 conjunctival nevus 10.1 MMP9 TIMP1
6 microcystic meningioma 10.1 MMP9 TIMP1
7 sorsby fundus dystrophy 10.1 MMP9 TIMP1
8 nasal cavity squamous cell carcinoma 10.1 MMP9 TIMP1
9 inguinal hernia 10.1 MMP9 TIMP1
10 appendicitis 10.1 MMP9 TIMP1
11 pediatric multiple sclerosis 10.1 ITGA4 MMP9
12 hydronephrosis 10.1 MMP9 TIMP1
13 bronchiolitis obliterans 10.1 MMP9 TIMP1
14 pulmonary emphysema 10.1 MMP9 TIMP1
15 carotid artery disease 10.1 MMP9 TIMP1
16 varicose veins 10.1 MMP9 TIMP1
17 aging 10.1
18 photokeratitis 10.0 FASLG MMP9
19 aortic aneurysm, familial abdominal, 1 10.0 MMP9 TIMP1
20 relapsing-remitting multiple sclerosis 10.0 MMP9 TIMP1
21 lymphoma, large-cell, immunoblastic 10.0 MYC TIMP1
22 thrombophilia 10.0
23 periodontitis 10.0 MMP9 TIMP1
24 kawasaki disease 9.9 MMP9 TIMP1
25 aortic aneurysm 9.9 MMP9 TIMP1
26 malignant histiocytosis 9.9 LTA MYC
27 bile duct carcinoma 9.8 FASLG MYC
28 dermatitis, atopic 9.8
29 reflex sympathetic dystrophy 9.8
30 episodic pain syndrome, familial, 1 9.8
31 algoneurodystrophy 9.8
32 squamous cell carcinoma 9.8
33 post-thrombotic syndrome 9.8
34 dermatitis 9.8
35 central nervous system tuberculosis 9.7 FASLG MMP9 TIMP1
36 pulmonary fibrosis, idiopathic 9.7 FASLG MMP9 TIMP1
37 male reproductive organ cancer 9.7 MMP9 MYC
38 female reproductive organ cancer 9.7 MMP9 MYC
39 breast adenocarcinoma 9.7 MMP9 MYC
40 reproductive organ cancer 9.7 MMP9 MYC
41 gastrointestinal system cancer 9.7 MMP9 MYC
42 cell type cancer 9.6 MMP9 MYC
43 interstitial lung disease 9.6 MMP9 TIMP1
44 lung giant cell carcinoma 9.5 MMP9 MYC TIMP1
45 oral squamous cell carcinoma 9.4 MMP9 MYC
46 myocardial infarction 9.4 LTA MMP9 TIMP1
47 esophageal cancer 9.4 FASLG MMP9 MYC
48 ewing sarcoma 9.3 FASLG MMP9 MYC
49 multiple sclerosis 9.0 FASLG ITGA4 LTA MMP9 TIMP1

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to Chronic Venous Leg Ulcers

Symptoms & Phenotypes for Chronic Venous Leg Ulcers

GenomeRNAi Phenotypes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Salmonella-containing vacuole maturation GR00133-A-2 8.62 ITGA4 MYC

MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 MYC FASLG TIMP1 ITGA4 LTA MMP9
2 hematopoietic system MP:0005397 9.88 MYC FASLG TIMP1 ITGA4 LTA MMP9
3 immune system MP:0005387 9.85 MYC FASLG TIMP1 ITGA4 LTA MMP9
4 mortality/aging MP:0010768 9.73 MMP9 MYC FASLG ITGA4 TIMP1 LTA
5 limbs/digits/tail MP:0005371 9.62 MMP9 MYC TIMP1 LTA
6 neoplasm MP:0002006 9.46 MMP9 MYC FASLG TIMP1
7 respiratory system MP:0005388 9.26 MMP9 FASLG TIMP1 LTA
8 skeleton MP:0005390 9.02 MYC FASLG TIMP1 LTA MMP9

Drugs & Therapeutics for Chronic Venous Leg Ulcers

Drugs for Chronic Venous Leg Ulcers (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Carboxymethylcellulose Sodium Phase 4
2 Cathartics Phase 4
3 Gastrointestinal Agents Phase 4
4 Laxatives Phase 4
5
Thrombin Approved, Investigational Phase 3
6 Coagulants Phase 3
7 Hemostatics Phase 3
8 Pharmaceutical Solutions Phase 3
9 Mitogens Phase 1, Phase 2
10 Anti-Bacterial Agents Phase 2
11 Anti-Infective Agents Phase 2
12 insulin Phase 2
13 Insulin, Globin Zinc Phase 2
14 Somatomedin B Phase 2
15
Mineral oil Approved, Vet_approved 8042-47-5
16
Ibuprofen Approved 15687-27-1 3672
17 monensin
18 Omega 3 Fatty Acid Nutraceutical

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers Completed NCT01084577 Phase 4
2 TruSkin®: Study for Treatment of Chronic Venous Leg Ulcers Terminated NCT02936128 Phase 4
3 Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers Unknown status NCT02130310 Phase 3
4 Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy Unknown status NCT00678847 Phase 2, Phase 3
5 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3
6 Phase I/II Dose Ranging CHRONSEAL® Study in Venous Leg Ulcers Unknown status NCT00797706 Phase 1, Phase 2 CHRONSEAL
7 EASH Dressing on Chronic Venous Leg Ulcers Completed NCT01497210 Phase 2
8 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers Completed NCT01801891 Phase 2
9 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
10 Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers Completed NCT00825760 Phase 2 Topical PPA904 gel and light;Topical placebo gel plus light
11 Study of VF001-DP in Patients With Chronic Venous Leg Ulcers Recruiting NCT02973893 Phase 2
12 Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers Recruiting NCT02742844 Phase 1, Phase 2
13 Silica Gel Fiber Wound Dressing for Chronic Venous Leg Ulcers Terminated NCT00998673 Phase 2
14 A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers Terminated NCT02154087 Phase 2
15 Cell Therapy for Venous Leg Ulcers Pilot Study Completed NCT01750749 Phase 1
16 Testing Fish Oil Derivatives In Healing Of Chronic Venous Leg Ulcers Completed NCT01754506
17 Safety Evaluation of Biatain Ibu in Painful Chronic Venous Leg Ulcers Completed NCT00628004
18 Biatain Ibu vs. Biatain in Painful Chronic Venous Leg Ulcers Completed NCT00627094
19 MIST Ultrasound Therapy Compared to United Kingdom Standard Care for the Treatment of Non-healing Venous Leg Ulcers Completed NCT01671748
20 Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing Recruiting NCT02024243
21 VLU Non-inferiority Study Comparing a Dual Action Pneumatic Compression Device to Multi-layer Bandaging Active, not recruiting NCT02680834
22 Intermittent Pneumatic Compression of the Foot vs Geko Plus R-2 Neuromuscular Electrostimulation Device in Venous Leg Ulcer Patients Withdrawn NCT02912858

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf PMIDs: 12055943 12463767 20849380 18615798

Genetic Tests for Chronic Venous Leg Ulcers

Anatomical Context for Chronic Venous Leg Ulcers

MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

38
Skin, Testes, Neutrophil

Publications for Chronic Venous Leg Ulcers

Articles related to Chronic Venous Leg Ulcers:

(show top 50) (show all 129)
# Title Authors Year
1
Trichloroacetic acid (80%) as a chemical debridement method for chronic venous leg ulcers-A pilot study. ( 29334174 )
2018
2
Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: A comparative study. ( 28834103 )
2017
3
Unna boot central gauze technique for chronic venous leg ulcers. ( 28329467 )
2017
4
Reliability and Measurement Error of Digital Planimetry for the Measurement of Chronic Venous Leg Ulcers. ( 28922511 )
2017
5
Comparison of Efficacy of Autologous Platelet-rich Fibrin versus Saline Dressing in Chronic Venous Leg Ulcers: A Randomised Controlled Trial. ( 28529414 )
2017
6
EPAa88+a88DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double-blind, controlled study. ( 28758717 )
2017
7
Phase 3 Evaluation of HP802-247 in the Treatment of Chronic Venous Leg Ulcers. ( 27495869 )
2016
8
Estimating the Clinical Outcomes and Cost Differences Between Standard Care With and Without Cadexomer Iodine in the Management of Chronic Venous Leg Ulcers Using a Markov Model. ( 27356144 )
2016
9
Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review. ( 26408463 )
2015
10
Safety and performance evaluation of a next-generation antimicrobial dressing in patients with chronic venous leg ulcers. ( 26095122 )
2015
11
Nutritional profile of older adults with chronic venous leg ulcers: AA pilot study. ( 26141998 )
2015
12
Healing of Recalcitrant Chronic Venous Leg Ulcers by Punch Grafts Harvested From the Scalp. ( 26262948 )
2015
13
Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (>100A cm(2)) chronic venous leg ulcers. ( 25595397 )
2015
14
Randomized, controlled study of innovative spray formulation containing ozonated oil and I+-bisabolol in the topical treatment of chronic venous leg ulcers. ( 26280699 )
2015
15
Medical grade honey in the management of chronic venous leg ulcers. ( 26050953 )
2015
16
Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series. ( 25492574 )
2014
17
The Effect of a Connexin43-Based Peptide on the Healing of Chronic Venous Leg Ulcers: A Multicenter, Randomized Trial. ( 25072595 )
2014
18
Cost-effectiveness of three adjunct cellular/tissue-derived products used in the management of chronic venous leg ulcers. ( 25498775 )
2014
19
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343393 )
2014
20
Factors that influence healing of chronic venous leg ulcers: a retrospective cohort. ( 24937814 )
2014
21
Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines. ( 24618232 )
2014
22
The impact of chronic venous leg ulcers: a systematic review. ( 25492276 )
2014
23
Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm(Ar) VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622). ( 24666170 )
2014
24
Chronic venous leg ulcers: Effects of foam sclerotherapy on healing and recurrence. ( 25351907 )
2014
25
A topical haemoglobin spray for oxygenating chronic venous leg ulcers: a pilot study. ( 25382133 )
2014
26
Maggots as a wound debridement agent for chronic venous leg ulcers under graduated compression bandages: a randomised controlled trial. ( 25300315 )
2014
27
Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings. ( 24589044 )
2014
28
Cost-Effective Use of Silver Dressings for the Treatment of Hard-to-Heal Chronic Venous Leg Ulcers. ( 24945381 )
2014
29
Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. ( 24635169 )
2014
30
Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. ( 24839984 )
2014
31
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343392 )
2014
32
Effect of foam sclerotherapy on healing and long-term recurrence in chronic venous leg ulcers. ( 22422794 )
2013
33
Proteolytic activity by multiple bacterial species isolated from chronic venous leg ulcers degrades matrix substrates. ( 23118301 )
2013
34
Durability of healing from spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: A 6-month follow-up. ( 23927847 )
2013
35
Healing rates following venous surgery for chronic venous leg ulcers in an independent specialist vein unit. ( 22833505 )
2013
36
Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. ( 23531093 )
2013
37
Catheter-directed foam sclerotherapy for chronic venous leg ulcers. ( 24072751 )
2013
38
Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers. ( 23998779 )
2013
39
Neutrophil activity in chronic venous leg ulcers--a target for therapy? ( 23551462 )
2013
40
Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial. ( 22863328 )
2012
41
Healing of chronic venous leg ulcers could be affected by an interaction of the hemochromatosis gene polymorphism HFE H63D with the strength of compression treatment--a re-analysis of patients from previous studies. ( 22150832 )
2012
42
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. ( 22174074 )
2012
43
Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. ( 22018697 )
2012
44
A prospective, multi-centre, randomised, open label, parallel, comparative study to evaluate effects of AQUACELAr Ag and UrgotulAr Silver dressing on healing of chronic venous leg ulcers. ( 22066961 )
2012
45
Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic--a randomized, double-blind controlled study. ( 22074592 )
2012
46
Chronic venous leg ulcers: the future of cell-based therapies. ( 22863327 )
2012
47
Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome. ( 21392126 )
2011
48
Duration of wound fluid secretion from chronic venous leg ulcers is critical for interleukin-1I+, interleukin-1I^, interleukin-8 levels and fibroblast activation. ( 21786164 )
2011
49
Insufficient and incomplete shaving in chronic venous leg ulcers leads to a poor prognosis of the skin graft: a histomorphological analysis. ( 21893960 )
2011
50
Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or without postthrombotic syndrome. ( 21362083 )
2011

Variations for Chronic Venous Leg Ulcers

Expression for Chronic Venous Leg Ulcers

Search GEO for disease gene expression data for Chronic Venous Leg Ulcers.

Pathways for Chronic Venous Leg Ulcers

Pathways related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 FASLG ITGA4 LTA MMP9 MYC TIMP1
2
Show member pathways
13.36 FASLG ITGA4 LTA MYC TIMP1
3
Show member pathways
13.27 FASLG ITGA4 LTA MMP9 MYC TIMP1
4
Show member pathways
13.03 FASLG ITGA4 LTA TIMP1
5
Show member pathways
12.66 FASLG LTA MMP9 MYC TIMP1
6 12.53 FASLG MMP9 MYC
7
Show member pathways
12.53 FASLG ITGA4 LTA
8
Show member pathways
12.49 FASLG LTA MYC
9
Show member pathways
12.39 ITGA4 MMP9 TIMP1
10
Show member pathways
12.17 FASLG MMP9 MYC
11 11.85 FASLG MMP9 MYC
12 11.57 MMP9 TIMP1
13
Show member pathways
11.56 MYC TIMP1
14
Show member pathways
11.52 FASLG LTA
15 11.51 MMP9 MYC
16 11.49 ITGA4 LTA
17 11.47 MMP9 MYC
18 11.43 MMP9 MYC
19 11.37 ITGA4 LTA
20 11.34 MMP9 TIMP1
21 11.31 MMP9 TIMP1
22 11.22 FASLG MYC
23 11.1 FASLG ITGA4
24 10.98 FASLG MMP9 MYC TIMP1
25
Show member pathways
10.96 FASLG LTA MYC
26 10.8 MMP9 TIMP1
27 10.46 FASLG ITGA4 LTA TIMP1

GO Terms for Chronic Venous Leg Ulcers

Biological processes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.67 MMP9 MYC TIMP1
2 positive regulation of cell proliferation GO:0008284 9.65 FASLG MYC TIMP1
3 regulation of receptor activity GO:0010469 9.61 FASLG LTA TIMP1
4 positive regulation of apoptotic process GO:0043065 9.58 FASLG LTA MMP9
5 extracellular matrix disassembly GO:0022617 9.46 MMP9 TIMP1
6 negative regulation of fibroblast proliferation GO:0048147 9.37 LTA MYC
7 endodermal cell differentiation GO:0035987 9.32 ITGA4 MMP9
8 positive regulation of DNA binding GO:0043388 9.26 MMP9 MYC
9 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.16 FASLG MMP9
10 response to growth factor GO:0070848 8.96 FASLG MYC
11 positive regulation of glial cell proliferation GO:0060252 8.62 LTA MYC

Molecular functions related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 FASLG LTA
2 cytokine activity GO:0005125 8.8 FASLG LTA TIMP1

Sources for Chronic Venous Leg Ulcers

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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