MCID: CHR415
MIFTS: 45

Chronic Venous Leg Ulcers malady

Summaries for Chronic Venous Leg Ulcers

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32MalaCards
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MalaCards: Chronic Venous Leg Ulcers, also known as chronic ulcer of lower extremity, is related to dermatitis and chronic ulcer of skin. An important gene associated with Chronic Venous Leg Ulcers is NFKBIL1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1), and among its related pathways are Rheumatoid arthritis and Alpha-defensins. The compounds pge2 and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and heart, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Chronic Venous Leg Ulcers

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30LifeMap Discovery™, 44Novoseek, 60UMLS
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Aliases & Descriptions:

chronic venous leg ulcers 30 44
chronic ulcer of lower extremity 60


Related Diseases for Chronic Venous Leg Ulcers

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17GeneCards, 18GeneDecks
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Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.3ITGB2
2chronic ulcer of skin10.6
3venous insufficiency10.5
4thrombophilia10.4
5reflex sympathetic dystrophy10.2
6atopic dermatitis10.2
7hemochromatosis10.2
8contact dermatitis10.2
9hepatitis c10.0TGIF1
10gingivitis10.0TIMP1
11pulmonary disease, chronic obstructive10.0TIMP1
12peritonitis10.0ITGB2
13lichen planus10.0ITGB2
14crohn's disease10.0ITGA4
15thyroiditis10.0FASLG
16multiple myeloma10.0ITGA4
17adenoma10.0TGFBR2
18moyamoya disease10.0TGIF1
19meningioma10.0TGIF1
20dilated cardiomyopathy10.0BSG
21acute myocardial infarction10.0ITGB2
22gastric ulcer10.0FGF7
23sjogren's syndrome10.0FASLG
24tuberculosis10.0DEFA1, ITGB2
25liver cirrhosis10.0TIMP1
26duodenal ulcer10.0TGIF1, LTA
27hepatitis b10.0MMP3
28oral submucous fibrosis10.0TIMP1
29polycythemia10.0TIMP1
30aortic aneurysm10.0TGFBR2
31nephritis10.0LTA, ITGA4
32diabetes mellitus10.0MMP3, ITGB2
33pneumonia10.0ITGA4, FGF7
34seminoma10.0PDGFRA
35pituitary adenoma10.0TGFBR2
36myopia 610.0TGIF1
37lupus nephritis10.0LTA, ITGB2
38uveitis10.0LTA, ITGA4
39bronchopulmonary dysplasia10.0FGF7, TIMP1
40arteriosclerosis10.0TGIF1, PDGFRA
41sarcoidosis10.0LTA, TGIF1
42thromboembolism10.0TTF2
43retinoblastoma10.0TGFBR2, TGIF1
44laryngeal benign neoplasm10.0PLAU
45dementia10.0TTF2, MMP3
46galactosemia10.0TIMP1
47hepatitis10.0FASLG, LTA, TTF2
48laryngeal squamous cell carcinoma10.0TGFBR2, BSG
49cystic fibrosis10.0FGF7, DEFA1
50silicosis10.0FASLG

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to chronic venous leg ulcers

Clinical Features for Chronic Venous Leg Ulcers

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Drugs & Therapeutics for Chronic Venous Leg Ulcers

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Venous Leg Ulcers

Drug clinical trials:

Search ClinicalTrials for Chronic Venous Leg Ulcers

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Search CenterWatch for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf, PMIDs: 12055943, 12463767, 20849380, 18615798

Genetic Tests for Chronic Venous Leg Ulcers

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Anatomical Context for Chronic Venous Leg Ulcers

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32MalaCards
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MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

32
Skin, Testes, Heart

Animal Models for Chronic Venous Leg Ulcers or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9PDGFRA, ITGB2, LTA, FGF7, TGIF1
2MP:00036319.9TGIF1, MMP3, FGF7, LTA, TIMP2
3MP:00053889.8PDGFRA, FASLG, LTA, PLAU, TGFBR2
4MP:00053859.6TIMP1, PDGFRA, FASLG, ITGA4, ITGB2, LTA
5MP:00053909.6PDGFRA, FASLG, ITGB2, LTA, MMP3
6MP:00053979.3FASLG, PDGFRA, TIMP1, TIMP2, ITGA4, ITGB2
7MP:00053879.1TGFBR2, TIMP2, TIMP1, PDGFRA, FASLG, BSG

Publications for Chronic Venous Leg Ulcers

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50PubMed
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Articles related to Chronic Venous Leg Ulcers:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers. (23998779)
2013
2
Neutrophil activity in chronic venous leg ulcers--a target for therapy? (23551462)
2013
3
Proteolytic activity by multiple bacterial species isolated from chronic venous leg ulcers degrades matrix substrates. (23118301)
2013
4
Healing rates following venous surgery for chronic venous leg ulcers in an independent specialist vein unit. (22833505)
2013
5
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. (22174074)
2012
6
Chronic venous leg ulcers: the future of cell-based therapies. (22863327)
2012
7
Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. (22018697)
2012
8
A prospective, multi-centre, randomised, open label, parallel, comparative study to evaluate effects of AQUACELAr Ag and UrgotulAr Silver dressing on healing of chronic venous leg ulcers. (22066961)
2012
9
Healing of chronic venous leg ulcers could be affected by an interaction of the hemochromatosis gene polymorphism HFE H63D with the strength of compression treatment--a re-analysis of patients from previous studies. (22150832)
2012
10
Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome. (21392126)
2011
11
Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study. (21655269)
2011
12
Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? (21472223)
2010
13
Managing chronic venous leg ulcers: time for a new approach? (20216491)
2010
14
Managing chronic venous leg ulcers part 2: time for a new pragmatic approach? (20559185)
2010
15
Leg ulceration in chronic venous insufficiency caused by an absent inferior vena cava. (19734977)
2009
16
The use of sensory nerve stimulation and compression bandaging to improve sensory nerve function and healing of chronic venous leg ulcers. (20021401)
2009
17
Proteolytic activity in wound fluids and tissues derived from chronic venous leg ulcers. (19903304)
2009
18
Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*. (18336381)
2008
19
Evaluation of apoptotic cells and immunohistochemical detection of FAS, FAS-L, Bcl-2, Bax, p53 and c-Myc in the skin of patients with chronic venous leg ulcers. (18813857)
2008
20
Increased levels of human neutrophil alpha-defensins in chronic venous leg ulcers. (18472248)
2008
21
Multiplexed analysis of matrix metalloproteinases in leg ulcer tissue of patients with chronic venous insufficiency before and after compression therapy. (19128259)
2008
22
Contact sensitization in patients with chronic venous leg ulcers in Singapore. (17244077)
2007
23
A prospective study of the microbiology of chronic venous leg ulcers to reevaluate the clinical predictive value of tissue biopsies and swabs. (17244315)
2007
24
An exploration of the use of ultrasound in the treatment of chronic venous leg ulcers. (16669305)
2006
25
Chronic venous leg ulcers benefit from surgery: long-term results from 173 legs. (16950436)
2006
26
Comprehensive decision-analytic model and Bayesian value-of-information analysis: pentoxifylline in the treatment of chronic venous leg ulcers. (16706572)
2006
27
Evaluation of hypochlorous acid washes in the treatment of chronic venous leg ulcers. (16669304)
2006
28
The impact of differential expression of extracellular matrix metalloproteinase inducer, matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2 and PDGF-AA on the chronicity of venous leg ulcers. (16169261)
2006
29
Contact allergy in patients with chronic venous leg ulcers-- possible role of chronic venous insufficiency. (16487282)
2006
30
Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. (16286373)
2005
31
Risk factors for delayed healing and recurrence of chronic venous leg ulcers--an analysis of 1324 legs. (15570275)
2005
32
Improved healing rates for chronic venous leg ulcers: pilot study results from a randomized controlled trial of a community nursing intervention. (15985095)
2005
33
Does the use of low-level laser influence wound healing in chronic venous leg ulcers? (16178295)
2005
34
Successful treatment of chronic venous leg ulcers with lyophilized cultured epidermal allografts. (15818446)
2004
35
Use of medical honey in patients with chronic venous leg ulcers after split-skin grafting. (15575578)
2004
36
Pathomechanism of chronic venous insufficiency and leg ulcer. (15484713)
2004
37
Low-frequency ultrasound to manage chronic venous leg ulcers. (14593268)
2003
38
Efficacy of a 6-month treatment with Daflon 500 mg in patients with venous leg ulcers associated with chronic venous insufficiency. (12771852)
2003
39
Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers. (14681639)
2003
40
Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers. (11710945)
2001
41
Randomized, double-blind, placebo-controlled, dose- ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers. (10231502)
1999
42
Low intensity laser therapy for chronic venous leg ulcers. (10983060)
1999
43
Proliferation and mitogenic response to PDGF-BB of fibroblasts isolated from chronic venous leg ulcers is ulcer-age dependent. (10201530)
1999
44
Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation. (9314951)
1997
45
Cytokine and protease levels in healing and non-healing chronic venous leg ulcers. (8608341)
1995
46
Localization of platelet-derived growth factor receptor subunit expression in chronic venous leg ulcers. (17173552)
1995
47
Reflex sympathetic dystrophy. The other villain in chronic venous leg ulcers. (7930012)
1994
48
The healing of chronic venous leg ulcers with prepared human amnion. (2670029)
1989
49
Pinch grafting for chronic venous leg ulcers in general practice. (3912501)
1985
50
Sympathectomy in the treatment of chronic venous leg ulcers. (7149976)
1982

Genetic Variations for Chronic Venous Leg Ulcers

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Expression for genes affiliated with Chronic Venous Leg Ulcers

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Venous Leg Ulcers

Search GEO for disease gene expression data for Chronic Venous Leg Ulcers.

Pathways for genes affiliated with Chronic Venous Leg Ulcers

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Sources:
29KEGG, 53Reactome, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ITGB2, ATP6V1G2
210.2DEFA3, DEFA1
3
Hide members
10.1TIMP2, TIMP1, LTA
410.1PDGFRA, TIMP1, TIMP2
5
Hide members
10.1MMP3, TIMP1, TIMP2
610.1BSG, ITGA4, ITGB2
710.1ITGB2, ITGA4, FASLG
8
Hide members
10.1FGF7, ITGA4, PDGFRA
9
Hide members
10.1TGFBR2, FGF7, PDGFRA
1010.0PDGFRA, ITGB2, LTA, TGFBR2
11
Hide members
10.0TIMP2, TIMP1, BSG, MMP3
12
Hide members
10.0FASLG, ITGA4, ITGB2, LTA
13
Cell adhesion ECM remodeling
Hide members
10.0TIMP2, TIMP1, MMP3, PLAU
14
Hide members
10.0FGF7, ITGB2, ITGA4, PDGFRA
159.9DEFA3, MMP3, PLAU, TGFBR2
16
Hide members
9.9TGFBR2, FGF7, FASLG, PDGFRA
17
Hide members
9.7FGF7, TIMP2, TIMP1, ITGA4, ITGB2, LTA
18
Hide members
9.7TIMP2, TIMP1, PDGFRA, LTA, FGF7, TGFBR2
19
Hide members
9.6PDGFRA, ITGA4, ITGB2, DEFA3, DEFA1, FGF7
20
Hide members
9.6TIMP2, TIMP1, PDGFRA, ITGA4, ITGB2, LTA
21
Hide members
9.5TIMP2, TIMP1, PDGFRA, ITGA4, ITGB2, LTA
22
Hide members
9.5TIMP2, TIMP1, PDGFRA, ITGA4, ITGB2, LTA
23
Hide members
9.5TIMP2, TIMP1, PDGFRA, ITGA4, ITGB2, FGF7

Compounds for genes affiliated with Chronic Venous Leg Ulcers

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB
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Compounds related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1pge24410.8PLAU
2indomethacin44 59 28 1113.6PLAU
3glutamate4410.6ITGB2, DEFA1
4estradiol44 11 2412.5PLAU, FASLG
5cycloheximide4410.5FGF7, FASLG, LTA
6propionate4410.3TIMP2, MMP3, PLAU, TIMP1
71,10-phenanthroline44 211.3FASLG, TIMP1, TIMP2, MMP3
8rantes4410.3FASLG, ITGA4, ITGB2, LTA, FGF7
9batimastat44 59 1112.3MMP3, TIMP1, PLAU, TIMP2
10latanoprost44 1111.2TIMP2, TIMP1, MMP3
11tamoxifen44 49 28 1113.2TGFBR2, TGIF1, FASLG, FGF7
12doxycycline44 1111.1PLAU, MMP3, FGF7, FASLG, TIMP1, TGIF1
13nimesulide44 1111.1MMP3, PLAU, TIMP1
14aspartate4410.1FASLG, FGF7, ITGA4, ITGB2, PDGFRA
15infliximab44 49 1112.1TIMP1, ITGA4, LTA, MMP3
16herbimycin a44 5911.1PLAU, ITGB2, TIMP1, TIMP2, LTA
17cytochalasin d44 5911.1MMP3, ITGB2, TGIF1, FASLG, ITGA4, TIMP2
18dexamethasone44 49 28 1113.1ITGA4, TGIF1, TIMP1, ITGB2, FASLG, TGFBR2
19ivig4410.1ITGB2
20nitric oxide44 11 2412.1TGFBR2, ITGB2, ITGA4, FASLG, TTF2, TIMP1
21cyclosporin a44 28 5912.0BSG, TIMP2, ITGB2, TTF2, TGFBR2, LTA
22sb 20358044 5911.0PLAU, FASLG, BSG, ITGB2, MMP3, TIMP2
23paraffin4410.0PLAU, MMP3, LTA, FASLG, PDGFRA, TIMP1
24ribonucleic acid4410.0TGFBR2, TIMP2, TIMP1, TGIF1, FGF7, MMP3
25matrigel4410.0PLAU, FGF7, TIMP2, MMP3, TIMP1, BSG
26serine4410.0TIMP1, TTF2, MMP3, FGF7, LTA, ITGA4
27ly2940024410.0PLAU, FASLG, BSG, TIMP2, TGFBR2, TIMP1
28glucose449.9TIMP2, DEFA1, TTF2, TGFBR2, FASLG, BSG
29vitamin d449.9TGFBR2, TIMP1, ITGB2, LTA, FGF7, TTF2
3012-o-tetradecanoylphorbol 13-acetate449.9LTA, MMP3, TGIF1, PLAU, ITGB2, TIMP1
31actinomycin d449.9TIMP2, TGFBR2, PLAU, FGF7, LTA, FASLG
32hyaluronic acid44 2410.9LTA, FASLG, TIMP1, ITGB2, PLAU, MMP3
33oxygen44 2410.9TTF2, ITGA4, FGF7, TIMP2
34pd 98,059449.8PLAU, MMP3, FGF7, FASLG, TIMP2, TIMP1
35lactate449.8TGIF1, PLAU, MMP3, ITGB2, BSG, FASLG
36h2o2449.8TIMP2, TIMP1, FASLG, LTA, FGF7, ITGB2
37tgf beta1449.8TIMP1, PDGFRA, FASLG, LTA, FGF7, MMP3
38oligonucleotide449.8TIMP2, PDGFRA, TGFBR2, TGIF1, FGF7, LTA
39adenylate449.8TIMP1, TGFBR2, PLAU, ITGB2, TIMP2, FGF7
40genistein44 28 59 2 11 2414.8ITGB2, TGIF1, PLAU, MMP3, ITGA4, FASLG
41cholesterol44 28 11 2412.8FASLG, TGIF1, TGFBR2, BSG, TIMP1, ITGB2
42alanine449.7TGFBR2, ITGB2, MMP3, TTF2, PLAU, FASLG
43heparin44 28 11 2412.7FGF7, TGIF1, TTF2, TIMP2, TIMP1, FASLG
44wortmannin449.7FASLG, PLAU, ITGA4, ITGB2, FGF7, TGFBR2
45cysteine449.6TGIF1, PLAU, FGF7, ITGB2, TTF2, FASLG
46progesterone44 59 28 11 2413.6BSG, TGFBR2, TGIF1, FASLG, PLAU, TTF2
47tyrosine449.5LTA, ITGA4, BSG, FASLG, PDGFRA, TIMP1
48retinoic acid44 2410.4LTA, TGFBR2, TGIF1, TIMP2, TIMP1, PDGFRA
49vegf449.4TIMP2, FASLG, BSG, ITGB2, LTA, FGF7
50calcium44 49 11 2412.3FASLG, PDGFRA, TGFBR2, ITGB2, TGIF1, TTF2

GO Terms for genes affiliated with Chronic Venous Leg Ulcers

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16Gene Ontology
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Cellular components related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9TGFBR2, ITGA4, FASLG, PDGFRA
2extracellular regionGO:0055769.5TIMP1, FASLG, DEFA3, FGF7, MMP3, PLAU
3extracellular spaceGO:0056159.4TIMP2, FASLG, DEFA3, LTA, MMP3, PLAU

Biological processes related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:02261710.1TIMP2, TIMP1, MMP3
2agingGO:00756810.1TGFBR2, TIMP1, TIMP2
3positive regulation of cell proliferationGO:0082849.9TGFBR2, FGF7, FASLG, PDGFRA, TIMP1
4blood coagulationGO:0075969.9TIMP1, BSG, ITGA4, ITGB2, PLAU
5extracellular matrix organizationGO:0301989.9MMP3, PDGFRA, TIMP1, TIMP2
6response to drugGO:0424939.7TIMP2, LTA, TGIF1, TGFBR2

Molecular functions related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:00819110.2TIMP1, TIMP2

Products for genes affiliated with Chronic Venous Leg Ulcers

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Venous Leg Ulcers

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet