MCID: CHR415
MIFTS: 35

Chronic Venous Leg Ulcers malady

Summaries for Chronic Venous Leg Ulcers

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34MalaCards
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MalaCards: Chronic Venous Leg Ulcers, also known as chronic ulcer of lower extremity, is related to atopic dermatitis and blindness. An important gene associated with Chronic Venous Leg Ulcers is NFKBIL1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1). The compounds neopterin and p003 have been mentioned in the context of this disorder. Affiliated tissues include skin and testes, and related mouse phenotype immune system.

Aliases & Classifications for Chronic Venous Leg Ulcers

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Sources:
32LifeMap Discoveryā„¢, 46Novoseek, 63UMLS
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Aliases & Descriptions:

chronic venous leg ulcers 32 46
chronic ulcer of lower extremity 63


Related Diseases for Chronic Venous Leg Ulcers

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis30.4LTA, TTF2
2blindness10.6
3chronic venous insufficiency10.4
4thrombophilia10.4
5venous insufficiency10.4
6reflex sympathetic dystrophy10.3
7post-thrombotic syndrome10.3
8hemochromatosis10.3
9dermatitis10.3
10adult respiratory distress syndrome10.0LTA, ELANE
11periodontitis10.0LTA, ELANE
12hypertriglyceridemia10.0LTA, TTF2
13septic shock10.0LTA, ELANE
14pulmonary sarcoidosis10.0LTA, ITGA4
15uveitis10.0LTA, ITGA4
16nephritis10.0LTA, ITGA4
17encephalomyelitis10.0ITGA4, LTA
18coronary artery disease10.0LTA, TTF2
19vasculitis10.0ELANE, ITGA4
20allergic asthma10.0ITGA4, LTA
21duodenal ulcer10.0LTA, TGIF1
22chronic lymphocytic leukemia10.0ITGA4, LTA
23hypercalcemia10.0LTA, TGIF1
24hepatitis10.0LTA, TTF2
25pneumonia10.0ITGA4, ELANE
26sarcoidosis10.0LTA, TGIF1
27pulmonary fibrosis10.0TGIF1, ELANE
28bronchitis10.0ITGA4, TGIF1
29t-cell leukemia10.0LTA, ITGA4, TTF2
30arthritis10.0LTA, ITGA4, TTF2
31herpes simplex10.0TTF2, TGIF1
32ipex syndrome10.0TTF2, TGIF1, LTA
33hodgkin's lymphoma10.0TGIF1, ITGA4, LTA
34astrocytoma10.0TGIF1, ITGA4, LTA
35primary hyperoxaluria9.9TGIF1, ITGA4, LTA
36glomerulonephritis9.9ITGA4, ELANE, TGIF1
37liver cirrhosis9.9TTF2, TGIF1
38sepsis9.9TTF2, ELANE, ITGA4, LTA
39prostate cancer9.9TTF2, TGIF1, LTA
40leukemia9.9LTA, ITGA4, TGIF1
41myeloid leukemia9.9LTA, ELANE, TGIF1, TTF2
42rheumatoid arthritis9.9LTA, ITGA4, ELANE, TGIF1
43ulcerative colitis9.9TGIF1, ELANE, ITGA4, LTA
44inflammatory bowel disease9.9TGIF1, ELANE, ITGA4, LTA
45psoriasis9.9TGIF1, ELANE, ITGA4, LTA
46stomach cancer9.9TTF2, TGIF1, ITGA4, LTA
47asthma9.9TTF2, TGIF1, ELANE, ITGA4

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to chronic venous leg ulcers

Symptoms for Chronic Venous Leg Ulcers

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Drugs & Therapeutics for Chronic Venous Leg Ulcers

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Chronic Venous Leg Ulcers

Drug clinical trials:

Search ClinicalTrials for Chronic Venous Leg Ulcers

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Search CenterWatch for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf, PMIDs: 12055943, 12463767, 20849380, 18615798

Genetic Tests for Chronic Venous Leg Ulcers

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Anatomical Context for Chronic Venous Leg Ulcers

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34MalaCards
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MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

34
Skin, Testes

Animal Models for Chronic Venous Leg Ulcers or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1LTA, ITGA4, ELANE, TGIF1

Publications for Chronic Venous Leg Ulcers

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Sources:
53PubMed
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Articles related to Chronic Venous Leg Ulcers:

(show top 50)    (show all 98)
idTitleAuthorsYear
1
Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers. (23998779)
2013
2
Neutrophil activity in chronic venous leg ulcers--a target for therapy? (23551462)
2013
3
Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. (23531093)
2013
4
Catheter-directed foam sclerotherapy for chronic venous leg ulcers. (24072751)
2013
5
Effect of foam sclerotherapy on healing and long-term recurrence in chronic venous leg ulcers. (22422794)
2013
6
Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic--a randomized, double-blind controlled study. (22074592)
2012
7
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. (22174074)
2012
8
Chronic venous leg ulcers: the future of cell-based therapies. (22863327)
2012
9
Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. (22018697)
2012
10
Duration of wound fluid secretion from chronic venous leg ulcers is critical for interleukin-1I+, interleukin-1I^, interleukin-8 levels and fibroblast activation. (21786164)
2011
11
Insufficient and incomplete shaving in chronic venous leg ulcers leads to a poor prognosis of the skin graft: a histomorphological analysis. (21893960)
2011
12
Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or without postthrombotic syndrome. (21362083)
2011
13
Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome. (21392126)
2011
14
Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. (20558044)
2010
15
Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? (21472223)
2010
16
Managing chronic venous leg ulcers: time for a new approach? (20216491)
2010
17
Why do chronic venous leg ulcers not heal? (19287249)
2009
18
The use of sensory nerve stimulation and compression bandaging to improve sensory nerve function and healing of chronic venous leg ulcers. (20021401)
2009
19
Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier. (18384617)
2008
20
Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*. (18336381)
2008
21
Evaluation of apoptotic cells and immunohistochemical detection of FAS, FAS-L, Bcl-2, Bax, p53 and c-Myc in the skin of patients with chronic venous leg ulcers. (18813857)
2008
22
Contact allergy to glucocorticosteroids in patients with chronic venous leg ulcers, atopic dermatitis and contact allergy. (18541102)
2008
23
Neurovascular changes after four-layer compression bandaging in people with chronic venous leg ulcers. (18268849)
2007
24
An exploration of the use of ultrasound in the treatment of chronic venous leg ulcers. (16669305)
2006
25
Chronic venous leg ulcers benefit from surgery: long-term results from 173 legs. (16950436)
2006
26
Comprehensive decision-analytic model and Bayesian value-of-information analysis: pentoxifylline in the treatment of chronic venous leg ulcers. (16706572)
2006
27
Chronic venous leg ulcers: effect of a community nursing intervention on pain and healing. (16163986)
2005
28
Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. (16286373)
2005
29
Risk factors for delayed healing and recurrence of chronic venous leg ulcers--an analysis of 1324 legs. (15570275)
2005
30
Oxidative stress in chronic venous leg ulcers. (16176453)
2005
31
Improved healing rates for chronic venous leg ulcers: pilot study results from a randomized controlled trial of a community nursing intervention. (15985095)
2005
32
Successful treatment of chronic venous leg ulcers with lyophilized cultured epidermal allografts. (15818446)
2004
33
Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension. (15453833)
2004
34
Autologous cultured keratinocytes on porcine gelatin microbeads effectively heal chronic venous leg ulcers. (15086765)
2004
35
Low-frequency ultrasound to manage chronic venous leg ulcers. (14593268)
2003
36
Sensory testing in patients with chronic venous leg ulcers using a 10 g Owen Mumford monofilament. (12838598)
2003
37
Cytokines and growth factors in keratinocytes and sweat glands in chronic venous leg ulcers. An immunohistochemical study. (12950634)
2003
38
The prevalence of thrombophilia in patients with chronic venous leg ulceration. (11932669)
2002
39
Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers. (11710945)
2001
40
Living with chronic venous leg ulcers: a descriptive study of knowledge and functional health status. (10778025)
2000
41
Expression of tissue-type and urokinase-type plasminogen activator activities in chronic venous leg ulcers. (10409920)
1999
42
Randomized, double-blind, placebo-controlled, dose- ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers. (10231502)
1999
43
Low intensity laser therapy for chronic venous leg ulcers. (10983060)
1999
44
Trial of two bandaging systems for chronic venous leg ulcers. (9325829)
1997
45
Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation. (9314951)
1997
46
Colour duplex ultrasonography in the rational management of chronic venous leg ulcers. (8944433)
1996
47
Cytokine and protease levels in healing and non-healing chronic venous leg ulcers. (8608341)
1995
48
The effect of aspirin on haemostatic activity in the treatment of chronic venous leg ulceration. (7718459)
1995
49
Abnormal lymph drainage in patients with chronic venous leg ulcers. (8463459)
1993
50
Diurnal variations in lower leg subcutaneous blood flow rate in patients with chronic venous leg ulcers. (1751349)
1991

Variations for Chronic Venous Leg Ulcers

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Expression for genes affiliated with Chronic Venous Leg Ulcers

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Chronic Venous Leg Ulcers

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Pathways for genes affiliated with Chronic Venous Leg Ulcers

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Compounds for genes affiliated with Chronic Venous Leg Ulcers

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1neopterin469.8ELANE, LTA
2p003469.8LTA, TTF2
3phorbol 12,13-dibutyrate469.8ITGA4, LTA
4infliximab46 52 1211.8LTA, ITGA4
5ivig469.8ITGA4, LTA
6methacholine46 52 1211.7ITGA4, TTF2
7thyroxine46 2510.6LTA, ELANE
8hyaluronic acid46 2510.6ELANE, LTA
9lead469.6ITGA4, TTF2
10carbon469.5ELANE, TTF2
11endotoxin469.5LTA, ELANE
12doxycycline46 1210.5ELANE, TGIF1
13nicotine46 30 52 1212.4ELANE, TTF2
141,25 dihydroxy vitamin d3469.4TTF2, TGIF1
15tgf beta1469.4LTA, TGIF1
16cyclosporin a46 30 6211.4LTA, ELANE, TTF2
17pentoxifylline46 1210.3LTA, ITGA4, ELANE
18fmlp469.3LTA, ITGA4, ELANE
19cytochalasin d46 6210.2ITGA4, TGIF1
20fibrinogen469.2ITGA4, ELANE, TTF2
21pge2469.1LTA, ELANE, TGIF1
22lactate469.1TGIF1, ELANE, LTA
23progesterone46 30 62 25 1213.0LTA, TGIF1, TTF2
24h2o2469.0LTA, ELANE, TGIF1
25cholesterol46 30 25 1212.0TTF2, TGIF1, LTA
26steroid469.0LTA, TGIF1, TTF2
27vegf469.0LTA, TGIF1, TTF2
28threonine468.9TTF2, TGIF1, LTA
29cyclic amp46 259.9LTA, ITGA4, TGIF1
30glutamate468.9TGIF1, ELANE, LTA
31vitamin d468.6LTA, ELANE, TGIF1, TTF2
32glucose468.6LTA, ITGA4, TTF2
33estrogen468.6LTA, ELANE, TGIF1, TTF2
34cysteine468.5TTF2, TGIF1, ELANE
35dexamethasone46 52 30 1211.5TTF2, TGIF1, ITGA4, LTA
36nitric oxide46 25 1210.5TTF2, TGIF1, ITGA4, LTA
37retinoic acid46 259.5TGIF1, ELANE, ITGA4, LTA
38heparin46 30 25 1211.4TTF2, TGIF1, ELANE, ITGA4
39calcium46 52 25 1211.3LTA, ITGA4, TGIF1, TTF2
40oxygen46 259.0TTF2, TGIF1, ELANE, ITGA4, LTA
41serine467.9LTA, ITGA4, ELANE, TGIF1, TTF2

GO Terms for genes affiliated with Chronic Venous Leg Ulcers

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17Gene Ontology
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Biological processes related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.5LTA, ELANE
2negative regulation of growth of symbiont in hostGO:0441309.4LTA, ELANE
3leukocyte migrationGO:0509009.0ITGA4, ELANE

Molecular functions related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.6NFKBIL1, ITGA4, ELANE, TGIF1, TTF2

Products for genes affiliated with Chronic Venous Leg Ulcers

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Chronic Venous Leg Ulcers

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet