MCID: CHR415
MIFTS: 37

Chronic Venous Leg Ulcers malady

Aliases & Classifications for Chronic Venous Leg Ulcers

Aliases & Descriptions for Chronic Venous Leg Ulcers:

Name: Chronic Venous Leg Ulcers 38 52

Summaries for Chronic Venous Leg Ulcers

MalaCards based summary : Chronic Venous Leg Ulcers is related to autoimmune polyendocrine syndrome type 1 and chondrodysplasia punctata, rhizomelic, type 1. An important gene associated with Chronic Venous Leg Ulcers is TIMP1 (TIMP Metallopeptidase Inhibitor 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Petrolatum and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and testes, and related phenotypes are Decreased Salmonella-containing vacuole maturation and cardiovascular system

Related Diseases for Chronic Venous Leg Ulcers

Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 autoimmune polyendocrine syndrome type 1 10.2 MMP9 TIMP1
2 chondrodysplasia punctata, rhizomelic, type 1 10.2 MMP9 TIMP1
3 appendix carcinoid tumor 10.2 MMP9 TIMP1
4 schwannomatosis 10.1 MMP9 TIMP1
5 striated muscle rhabdoid tumor 10.1 MMP9 TIMP1
6 maxillary neoplasm 10.1 MMP9 TIMP1
7 adenoid squamous cell carcinoma 10.1 MMP9 TIMP1
8 retinal drusen 10.1 MMP9 TIMP1
9 nodular cutaneous amyloidosis 10.1 MMP9 TIMP1
10 penis agenesis 10.1 ITGA4 MMP9
11 chordoid meningioma 10.1 MMP9 TIMP1
12 perrault syndrome 10.1 ITGA4 TIMP1
13 breast abscess 10.1 MMP9 TIMP1
14 kernicterus due to isoimmunization 10.1 ITGA4 LTA
15 renal oncocytoma 10.1 MMP9 TIMP1
16 burns 10.1 MMP9 TIMP1
17 polyneuropathy in collagen vascular disease 10.1 FASLG MMP9
18 optic nerve neoplasm 10.0 MMP9 TIMP1
19 lysosomal storage disease 10.0 MYC TIMP1
20 mixed ductal-endocrine carcinoma 10.0 MMP9 TIMP1
21 neonatal jaundice 10.0 MMP9 TIMP1
22 breast adenomyoepithelioma 9.9 FASLG MMP9 TIMP1
23 aortic aneurysm, familial thoracic 6 9.9 FASLG MMP9 TIMP1
24 advanced sleep phase syndrome, familial, 1 9.9 ITGA4 LTA MMP9
25 central nervous system teratoma 9.9 MMP9 TIMP1
26 chronic venous insufficiency 9.9
27 venous insufficiency 9.9
28 thrombophilia 9.9
29 breast papillary carcinoma 9.9 MMP9 MYC TIMP1
30 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 9.8 MMP9 MYC TIMP1
31 pituitary carcinoma 9.8 FASLG MYC
32 hemochromatosis 9.7
33 reflex sympathetic dystrophy 9.7
34 squamous cell carcinoma 9.7
35 post-thrombotic syndrome 9.7
36 dermatitis 9.7
37 atopic dermatitis 9.7
38 nail disorder, nonsyndromic congenital, 3, 9.7 FASLG MMP9 MYC
39 congenital hypomyelination neuropathy 9.2 FASLG ITGA4 LTA MMP9 MYC TIMP1

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to Chronic Venous Leg Ulcers

Symptoms & Phenotypes for Chronic Venous Leg Ulcers

GenomeRNAi Phenotypes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Salmonella-containing vacuole maturation GR00133-A-2 8.62 ITGA4 MYC

MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 FASLG ITGA4 LTA MMP9 MYC TIMP1
2 hematopoietic system MP:0005397 9.88 FASLG ITGA4 LTA MMP9 MYC TIMP1
3 immune system MP:0005387 9.85 FASLG ITGA4 LTA MMP9 MYC TIMP1
4 mortality/aging MP:0010768 9.73 FASLG ITGA4 LTA MMP9 MYC TIMP1
5 limbs/digits/tail MP:0005371 9.62 LTA MMP9 MYC TIMP1
6 neoplasm MP:0002006 9.46 FASLG MMP9 MYC TIMP1
7 respiratory system MP:0005388 9.26 FASLG LTA MMP9 TIMP1
8 skeleton MP:0005390 9.02 LTA MMP9 MYC TIMP1 FASLG

Drugs & Therapeutics for Chronic Venous Leg Ulcers

Drugs for Chronic Venous Leg Ulcers (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Petrolatum Approved Phase 4 8009-03-8
2
Coal tar Approved Phase 4 8007-45-2
3 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
4
Bismuth Phase 4,Phase 1 7440-69-9 16682734 105143
5 Mitogens Phase 4,Phase 3,Phase 1,Phase 2
6 Carboxymethylcellulose Sodium Phase 4,Phase 3
7 Cathartics Phase 4,Phase 3
8 Gastrointestinal Agents Phase 4,Phase 3,Phase 1
9 Laxatives Phase 4,Phase 3
10 Aminaftone Phase 4
11 Coagulants Phase 4,Phase 3
12 Hemostatics Phase 4,Phase 3
13
Ibuprofen Approved Phase 3 15687-27-1 3672
14
Isosorbide Dinitrate Approved Phase 3 87-33-2 6883
15
Nitric Oxide Approved Phase 3,Phase 1 10102-43-9 145068
16
Sorbitol Approved Phase 3 50-70-4 5780
17
Glucosamine Approved, Nutraceutical Phase 3,Early Phase 1 3416-24-8 439213
18 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
19 Anticholesteremic Agents Phase 3
20 Antimetabolites Phase 3
21 Chelating Agents Phase 3
22 diuretics Phase 3
23 Hypolipidemic Agents Phase 3
24 Isosorbide Phase 3
25 isosorbide-5-mononitrate Phase 3
26 Lipid Regulating Agents Phase 3
27 Natriuretic Agents Phase 3
28 Nitric Oxide Donors Phase 3,Phase 1
29 Vasodilator Agents Phase 3,Phase 1
30 Angiogenesis Inducing Agents Phase 3,Phase 1
31 Angiogenesis Modulating Agents Phase 3,Phase 1
32 Platelet-derived growth factor BB Phase 3,Phase 1
33 Bone Density Conservation Agents Phase 3,Phase 2
34 Calcium, Dietary Phase 3,Phase 1,Phase 2
35 Thrombin Phase 3
36 HIV Protease Inhibitors Phase 3,Phase 1
37
protease inhibitors Phase 3,Phase 1
38 Anti-HIV Agents Phase 3
39 Anti-Retroviral Agents Phase 3
40 Antiviral Agents Phase 3
41 Calcium Dobesilate Phase 3
42
Chitosan Nutraceutical Phase 3 9012-76-4 71853
43 Citrate Nutraceutical Phase 3,Phase 1,Phase 2
44
Citric Acid Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 77-92-9 311
45
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
46
Methyl salicylate Approved, Vet_approved Phase 2 119-36-8 4133
47
Timolol Approved Phase 2 26839-75-8 33624 5478
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 59-30-3 6037
49
Pyridoxal Approved, Nutraceutical Phase 2 66-72-8 1050
50
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 2 65-23-6 1054

Interventional clinical trials:

(show top 50) (show all 139)
id Name Status NCT ID Phase
1 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
2 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers Completed NCT01084577 Phase 4
3 DermACELL in Subjects With Chronic Wounds of the Lower Extremities Completed NCT01970163 Phase 4
4 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
5 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
6 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4
7 Effectiveness of Aurix Therapy in Venous Leg Ulcers Recruiting NCT02352454 Phase 4
8 ACTICOAT™ for the Treatment of Burns and Chronic Wounds Not yet recruiting NCT02852148 Phase 4
9 TruSkin®: Study for Treatment of Chronic Venous Leg Ulcers Terminated NCT02936128 Phase 4
10 Effectiveness of Aurix Therapy in Venous Leg Ulcers Withdrawn NCT02940587 Phase 4
11 A Post-Marketing Clinical Study of Apligraf for Venous Leg Ulcers Withdrawn NCT00648674 Phase 4
12 A Comparison of OASIS Wound Matrix With Approved Dressings for Skin Graft Donor Sites Withdrawn NCT02994589 Phase 4
13 Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy Unknown status NCT00678847 Phase 2, Phase 3
14 Biatain Ibu vs. Biatain in Painful Chronic Venous Leg Ulcers Completed NCT00627094 Phase 3
15 THERMES ET VEINES: Spa for Prevention of Leg Ulcers Completed NCT00838500 Phase 3
16 Study to Evaluate the Performance of AQUACEL® Extra™ in Venous Leg Ulcers Completed NCT01591434 Phase 3
17 Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers Completed NCT00909870 Phase 3
18 Open Multi-centre Investigation to Evaluate Signs and Symptoms of Local Inflammation/Infection on Chronic Ulcers and Partial Thickness Burns When Using Mepilex Border Ag as an Anti-microbial Wound Dressing Completed NCT01214811 Phase 3
19 Efficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot Ulcers Completed NCT02789033 Phase 3
20 Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum Recruiting NCT02802995 Phase 3
21 Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers Active, not recruiting NCT02130310 Phase 3
22 PRP ULCERAS: Clinical Trial Phase III Active, not recruiting NCT02213952 Phase 3
23 Clinical Trial of ECLIPSE PRP™ Wound Biomatrix in Chronic Non-Healing Venous Leg Ulcers Not yet recruiting NCT02312518 Phase 2, Phase 3
24 Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing Not yet recruiting NCT02845466 Phase 3
25 Calcium Dobesilate for Chronic Venous Wounds Suspended NCT00979836 Phase 3
26 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3
27 Clinical Effectiveness of Topical Autologous Platelet Gel for the Treatment of Venous Ulcers Withdrawn NCT00273234 Phase 3
28 A Prospective Randomized, Double-Blind, Placebo-Controlled Trial Comparing VitroGro® ECM to Placebo in Patients With Venous Leg Ulcers Withdrawn NCT01982318 Phase 2, Phase 3
29 Phase I/II Dose Ranging CHRONSEAL® Study in Venous Leg Ulcers Unknown status NCT00797706 Phase 1, Phase 2
30 Nursing Care With Patients With Venous Leg Ulcers Unknown status NCT02224300 Phase 2
31 Adipose Derived Regenerative Cellular Therapy of Chronic Wounds Unknown status NCT02092870 Phase 2
32 Non-Healing Ulcers Without Critical Limb Ischemia Unknown status NCT01666093 Phase 2
33 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers Completed NCT01801891 Phase 2
34 EASH Dressing on Chronic Venous Leg Ulcers Completed NCT01497210 Phase 2
35 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
36 Assessment of the Safety and Efficacy of DERMASTREAM™ - ENZYSTREAM™ System for the Treatment of Chronic Venous Ulcers Completed NCT00485329 Phase 1, Phase 2
37 Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers Completed NCT00825760 Phase 2
38 Feasibility and Safety and Evaluation of the Potential Efficacy of Autologous Platelet-rich Plasma in the Treatment of Vascular Venous Ulcers Completed NCT01817218 Phase 1, Phase 2
39 Extracorporeal Shockwave Treatment for Chronic Soft Tissue Wounds Completed NCT00545896 Phase 2
40 The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
41 Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers Completed NCT00399308 Phase 1, Phase 2
42 Community RCT of the Effectiveness of Two Compression Bandaging Technologies Completed NCT00202267 Phase 2
43 Evaluation of a Ionic Silver and Honey Preparation to Treat Chronic Wounds of the Lower Legs Completed NCT01111695 Phase 2
44 A Study to Investigate the Efficacy, Safety and Tolerability of Nexagon® as a Topical Treatment for Subjects With Venous Leg Ulcers Completed NCT01199588 Phase 2
45 SNaP Wound Care System Versus Traditional NPWT Device for Treatment of Chronic Wounds Completed NCT00951080 Phase 2
46 Safety Trial of the RedDress Wound Care System (RD1) in Management of Texas 1a or 2a Neuropathic Diabetic Foot Ulcers. Completed NCT01396837 Phase 2
47 Study of VF001-DP in Patients With Chronic Venous Leg Ulcers Recruiting NCT02973893 Phase 2
48 Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers Recruiting NCT02742844 Phase 1, Phase 2
49 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers Recruiting NCT03154619 Phase 2
50 Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence Recruiting NCT02626156 Phase 2

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf PMIDs: 12055943 12463767 20849380 18615798

Genetic Tests for Chronic Venous Leg Ulcers

Anatomical Context for Chronic Venous Leg Ulcers

MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

39
Skin, Neutrophil, Testes

Publications for Chronic Venous Leg Ulcers

Articles related to Chronic Venous Leg Ulcers:

(show top 50) (show all 123)
id Title Authors Year
1
Phase 3 Evaluation of HP802-247 in the Treatment of Chronic Venous Leg Ulcers. ( 27495869 )
2016
2
Estimating the Clinical Outcomes and Cost Differences Between Standard Care With and Without Cadexomer Iodine in the Management of Chronic Venous Leg Ulcers Using a Markov Model. ( 27356144 )
2016
3
Safety and performance evaluation of a next-generation antimicrobial dressing in patients with chronic venous leg ulcers. ( 26095122 )
2015
4
Medical grade honey in the management of chronic venous leg ulcers. ( 26050953 )
2015
5
Healing of Recalcitrant Chronic Venous Leg Ulcers by Punch Grafts Harvested From the Scalp. ( 26262948 )
2015
6
Randomized, controlled study of innovative spray formulation containing ozonated oil and I+-bisabolol in the topical treatment of chronic venous leg ulcers. ( 26280699 )
2015
7
Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (>100A cm(2)) chronic venous leg ulcers. ( 25595397 )
2015
8
Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review. ( 26408463 )
2015
9
Nutritional profile of older adults with chronic venous leg ulcers: AA pilot study. ( 26141998 )
2015
10
Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines. ( 24618232 )
2014
11
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343393 )
2014
12
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343392 )
2014
13
Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm(Ar) VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622). ( 24666170 )
2014
14
Maggots as a wound debridement agent for chronic venous leg ulcers under graduated compression bandages: a randomised controlled trial. ( 25300315 )
2014
15
Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings. ( 24589044 )
2014
16
Cost-Effective Use of Silver Dressings for the Treatment of Hard-to-Heal Chronic Venous Leg Ulcers. ( 24945381 )
2014
17
Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. ( 24839984 )
2014
18
The Effect of a Connexin43-Based Peptide on the Healing of Chronic Venous Leg Ulcers: A Multicenter, Randomized Trial. ( 25072595 )
2014
19
Cost-effectiveness of three adjunct cellular/tissue-derived products used in the management of chronic venous leg ulcers. ( 25498775 )
2014
20
Factors that influence healing of chronic venous leg ulcers: a retrospective cohort. ( 24937814 )
2014
21
A topical haemoglobin spray for oxygenating chronic venous leg ulcers: a pilot study. ( 25382133 )
2014
22
Chronic venous leg ulcers: Effects of foam sclerotherapy on healing and recurrence. ( 25351907 )
2014
23
Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. ( 24635169 )
2014
24
Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series. ( 25492574 )
2014
25
The impact of chronic venous leg ulcers: a systematic review. ( 25492276 )
2014
26
Healing rates following venous surgery for chronic venous leg ulcers in an independent specialist vein unit. ( 22833505 )
2013
27
Neutrophil activity in chronic venous leg ulcers--a target for therapy? ( 23551462 )
2013
28
Effect of foam sclerotherapy on healing and long-term recurrence in chronic venous leg ulcers. ( 22422794 )
2013
29
Catheter-directed foam sclerotherapy for chronic venous leg ulcers. ( 24072751 )
2013
30
Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. ( 23531093 )
2013
31
Proteolytic activity by multiple bacterial species isolated from chronic venous leg ulcers degrades matrix substrates. ( 23118301 )
2013
32
Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers. ( 23998779 )
2013
33
Durability of healing from spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: A 6-month follow-up. ( 23927847 )
2013
34
Healing of chronic venous leg ulcers could be affected by an interaction of the hemochromatosis gene polymorphism HFE H63D with the strength of compression treatment--a re-analysis of patients from previous studies. ( 22150832 )
2012
35
Chronic venous leg ulcers: the future of cell-based therapies. ( 22863327 )
2012
36
Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial. ( 22863328 )
2012
37
A prospective, multi-centre, randomised, open label, parallel, comparative study to evaluate effects of AQUACELAr Ag and UrgotulAr Silver dressing on healing of chronic venous leg ulcers. ( 22066961 )
2012
38
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. ( 22174074 )
2012
39
Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic--a randomized, double-blind controlled study. ( 22074592 )
2012
40
Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. ( 22018697 )
2012
41
Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or without postthrombotic syndrome. ( 21362083 )
2011
42
Duration of wound fluid secretion from chronic venous leg ulcers is critical for interleukin-1I+, interleukin-1I^, interleukin-8 levels and fibroblast activation. ( 21786164 )
2011
43
Insufficient and incomplete shaving in chronic venous leg ulcers leads to a poor prognosis of the skin graft: a histomorphological analysis. ( 21893960 )
2011
44
Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome. ( 21392126 )
2011
45
Relationship between the seasonal onset of chronic venous leg ulcers and climatic factors. ( 21371131 )
2011
46
Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study. ( 21655269 )
2011
47
Managing chronic venous leg ulcers: time for a new approach? ( 20216491 )
2010
48
Characterization of tumor necrosis factor-I+ block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. ( 20854863 )
2010
49
Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. ( 20558044 )
2010
50
Managing chronic venous leg ulcers part 2: time for a new pragmatic approach? ( 20559185 )
2010

Variations for Chronic Venous Leg Ulcers

Expression for Chronic Venous Leg Ulcers

Search GEO for disease gene expression data for Chronic Venous Leg Ulcers.

Pathways for Chronic Venous Leg Ulcers

Pathways related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 FASLG ITGA4 LTA MMP9 MYC TIMP1
2
Show member pathways
13.44 FASLG ITGA4 LTA MYC TIMP1
3
Show member pathways
13.11 FASLG ITGA4 LTA MMP9 MYC TIMP1
4
Show member pathways
13.04 FASLG ITGA4 LTA TIMP1
5
Show member pathways
12.77 FASLG LTA MMP9 MYC TIMP1
6
Show member pathways
12.53 FASLG ITGA4 LTA
7
Show member pathways
12.49 FASLG LTA MYC
8
Show member pathways
12.38 ITGA4 MMP9 TIMP1
9 12.27 FASLG MMP9 MYC
10 12.17 FASLG ITGA4 MYC
11 11.81 FASLG MMP9 MYC
12 11.57 MMP9 TIMP1
13
Show member pathways
11.56 MYC TIMP1
14
Show member pathways
11.54 FASLG LTA
15 11.51 MMP9 MYC
16 11.49 ITGA4 LTA
17 11.46 MMP9 MYC
18 11.42 MMP9 MYC
19 11.38 ITGA4 LTA
20 11.32 MMP9 TIMP1
21 11.3 MMP9 TIMP1
22 11.18 FASLG MYC
23 11.08 FASLG ITGA4
24 10.98 FASLG MMP9 MYC TIMP1
25
Show member pathways
10.96 FASLG LTA MYC
26 10.77 MMP9 TIMP1

GO Terms for Chronic Venous Leg Ulcers

Cellular components related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 FASLG LTA MMP9 TIMP1

Biological processes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.65 MMP9 MYC TIMP1
2 positive regulation of cell proliferation GO:0008284 9.63 FASLG MYC TIMP1
3 positive regulation of apoptotic process GO:0043065 9.58 FASLG LTA MMP9
4 extracellular matrix disassembly GO:0022617 9.43 MMP9 TIMP1
5 negative regulation of fibroblast proliferation GO:0048147 9.37 LTA MYC
6 endodermal cell differentiation GO:0035987 9.32 ITGA4 MMP9
7 positive regulation of DNA binding GO:0043388 9.26 MMP9 MYC
8 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.16 FASLG MMP9
9 response to growth factor GO:0070848 8.96 FASLG MYC
10 positive regulation of glial cell proliferation GO:0060252 8.62 LTA MYC

Molecular functions related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 FASLG LTA
2 cytokine activity GO:0005125 8.8 FASLG LTA TIMP1

Sources for Chronic Venous Leg Ulcers

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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