MCID: CHR415
MIFTS: 36

Chronic Venous Leg Ulcers malady

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Summaries for Chronic Venous Leg Ulcers

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MalaCards based summary: Chronic Venous Leg Ulcers, also known as chronic ulcer of lower extremity, is related to atopic dermatitis and blindness. An important gene associated with Chronic Venous Leg Ulcers is NFKBIL1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1). The compounds neopterin and p003 have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and testes, and related mouse phenotype immune system.

Aliases & Classifications for Chronic Venous Leg Ulcers

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Chronic Venous Leg Ulcers, Aliases & Descriptions:

Name: Chronic Venous Leg Ulcers 30 44
 
Chronic Ulcer of Lower Extremity 62


Related Diseases for Chronic Venous Leg Ulcers

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Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis30.6LTA, TTF2
2blindness10.6
3chronic venous insufficiency10.4
4thrombophilia10.4
5venous insufficiency10.4
6post-thrombotic syndrome10.3
7hemochromatosis10.3
8reflex sympathetic dystrophy10.3
9dermatitis10.3
10adult respiratory distress syndrome10.2LTA, ELANE
11periodontitis10.2LTA, ELANE
12hypertriglyceridemia10.2LTA, TTF2
13septic shock10.2LTA, ELANE
14pulmonary sarcoidosis10.2LTA, ITGA4
15uveitis10.1LTA, ITGA4
16nephritis10.1LTA, ITGA4
17coronary artery anomaly10.1LTA, TTF2
18vasculitis10.1ELANE, ITGA4
19allergic asthma10.1ITGA4, LTA
20chronic lymphocytic leukemia10.1ITGA4, LTA
21duodenal ulcer10.1LTA, TGIF1
22hypercalcemia10.1LTA, TGIF1
23hepatitis10.0LTA, TTF2
24pneumonia10.0ITGA4, ELANE
25sarcoidosis10.0LTA, TGIF1
26pulmonary fibrosis10.0TGIF1, ELANE
27non-suppurative otitis media10.0ITGA4, TGIF1
28t-cell leukemia9.9LTA, ITGA4, TTF2
29arthritis9.9LTA, ITGA4, TTF2
30herpes simplex9.8TTF2, TGIF1
31hodgkin's lymphoma9.8TGIF1, ITGA4, LTA
32ipex syndrome9.8TTF2, TGIF1, LTA
33astrocytoma9.8TGIF1, ITGA4, LTA
34primary hyperoxaluria9.8TGIF1, ITGA4, LTA
35glomerulonephritis9.8ITGA4, ELANE, TGIF1
36liver cirrhosis9.8TTF2, TGIF1
37sepsis9.7TTF2, ELANE, ITGA4, LTA
38prostate cancer9.7TTF2, TGIF1, LTA
39leukemia9.6LTA, ITGA4, TGIF1
40myeloid leukemia9.6LTA, ELANE, TGIF1, TTF2
41rheumatoid arthritis9.6LTA, ITGA4, ELANE, TGIF1
42ulcerative colitis9.6TGIF1, ELANE, ITGA4, LTA
43inflammatory bowel disease9.6TGIF1, ELANE, ITGA4, LTA
44psoriasis9.6TGIF1, ELANE, ITGA4, LTA
45stomach cancer9.6TTF2, TGIF1, ITGA4, LTA
46asthma9.6TTF2, TGIF1, ELANE, ITGA4

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to chronic venous leg ulcers

Symptoms for Chronic Venous Leg Ulcers

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Drugs & Therapeutics for Chronic Venous Leg Ulcers

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Drug clinical trials:

Search ClinicalTrials for Chronic Venous Leg Ulcers

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf, PMIDs: 12055943, 12463767, 20849380, 18615798

Genetic Tests for Chronic Venous Leg Ulcers

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Anatomical Context for Chronic Venous Leg Ulcers

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MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

32
Skin, Neutrophil, Testes

Animal Models for Chronic Venous Leg Ulcers or affiliated genes

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MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1LTA, ITGA4, ELANE, TGIF1

Publications for Chronic Venous Leg Ulcers

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Articles related to Chronic Venous Leg Ulcers:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings. (24589044)
2014
2
Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. (24839984)
2014
3
Chronic venous leg ulcers: Effects of foam sclerotherapy on healing and recurrence. (25351907)
2014
4
Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. (24635169)
2014
5
A topical haemoglobin spray for oxygenating chronic venous leg ulcers: a pilot study. (25382133)
2014
6
Maggots as a wound debridement agent for chronic venous leg ulcers under graduated compression bandages: a randomised controlled trial. (25300315)
2014
7
Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers. (23998779)
2013
8
Neutrophil activity in chronic venous leg ulcers--a target for therapy? (23551462)
2013
9
Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. (23531093)
2013
10
Catheter-directed foam sclerotherapy for chronic venous leg ulcers. (24072751)
2013
11
Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic--a randomized, double-blind controlled study. (22074592)
2012
12
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. (22174074)
2012
13
Chronic venous leg ulcers: the future of cell-based therapies. (22863327)
2012
14
Duration of wound fluid secretion from chronic venous leg ulcers is critical for interleukin-1I+, interleukin-1I^, interleukin-8 levels and fibroblast activation. (21786164)
2011
15
Insufficient and incomplete shaving in chronic venous leg ulcers leads to a poor prognosis of the skin graft: a histomorphological analysis. (21893960)
2011
16
Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or without postthrombotic syndrome. (21362083)
2011
17
Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. (20558044)
2010
18
Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? (21472223)
2010
19
Managing chronic venous leg ulcers: time for a new approach? (20216491)
2010
20
Why do chronic venous leg ulcers not heal? (19287249)
2009
21
The use of sensory nerve stimulation and compression bandaging to improve sensory nerve function and healing of chronic venous leg ulcers. (20021401)
2009
22
Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier. (18384617)
2008
23
Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*. (18336381)
2008
24
Evaluation of apoptotic cells and immunohistochemical detection of FAS, FAS-L, Bcl-2, Bax, p53 and c-Myc in the skin of patients with chronic venous leg ulcers. (18813857)
2008
25
An exploration of the use of ultrasound in the treatment of chronic venous leg ulcers. (16669305)
2006
26
Chronic venous leg ulcers benefit from surgery: long-term results from 173 legs. (16950436)
2006
27
Chronic venous leg ulcers: effect of a community nursing intervention on pain and healing. (16163986)
2005
28
Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. (16286373)
2005
29
Risk factors for delayed healing and recurrence of chronic venous leg ulcers--an analysis of 1324 legs. (15570275)
2005
30
Oxidative stress in chronic venous leg ulcers. (16176453)
2005
31
Improved healing rates for chronic venous leg ulcers: pilot study results from a randomized controlled trial of a community nursing intervention. (15985095)
2005
32
Successful treatment of chronic venous leg ulcers with lyophilized cultured epidermal allografts. (15818446)
2004
33
Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension. (15453833)
2004
34
Autologous cultured keratinocytes on porcine gelatin microbeads effectively heal chronic venous leg ulcers. (15086765)
2004
35
Low-frequency ultrasound to manage chronic venous leg ulcers. (14593268)
2003
36
Sensory testing in patients with chronic venous leg ulcers using a 10 g Owen Mumford monofilament. (12838598)
2003
37
Cytokines and growth factors in keratinocytes and sweat glands in chronic venous leg ulcers. An immunohistochemical study. (12950634)
2003
38
The prevalence of thrombophilia in patients with chronic venous leg ulceration. (11932669)
2002
39
Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers. (11710945)
2001
40
Living with chronic venous leg ulcers: a descriptive study of knowledge and functional health status. (10778025)
2000
41
Expression of tissue-type and urokinase-type plasminogen activator activities in chronic venous leg ulcers. (10409920)
1999
42
Randomized, double-blind, placebo-controlled, dose- ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers. (10231502)
1999
43
Trial of two bandaging systems for chronic venous leg ulcers. (9325829)
1997
44
Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation. (9314951)
1997
45
Activated protein C resistance caused by factor V gene mutation: common coagulation defect in chronic venous leg ulcers? (9092749)
1997
46
Colour duplex ultrasonography in the rational management of chronic venous leg ulcers. (8944433)
1996
47
Cytokine and protease levels in healing and non-healing chronic venous leg ulcers. (8608341)
1995
48
The effect of aspirin on haemostatic activity in the treatment of chronic venous leg ulceration. (7718459)
1995
49
Abnormal lymph drainage in patients with chronic venous leg ulcers. (8463459)
1993
50
Diurnal variations in lower leg subcutaneous blood flow rate in patients with chronic venous leg ulcers. (1751349)
1991

Variations for Chronic Venous Leg Ulcers

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Expression for genes affiliated with Chronic Venous Leg Ulcers

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Expression patterns in normal tissues for genes affiliated with Chronic Venous Leg Ulcers

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Pathways for genes affiliated with Chronic Venous Leg Ulcers

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Compounds for genes affiliated with Chronic Venous Leg Ulcers

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Compounds related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1neopterin449.8ELANE, LTA
2p003449.8LTA, TTF2
3phorbol 12,13-dibutyrate449.8ITGA4, LTA
4infliximab44 50 1111.8LTA, ITGA4
5ivig449.8ITGA4, LTA
6methacholine44 50 1111.7ITGA4, TTF2
7thyroxine44 2410.6LTA, ELANE
8hyaluronic acid44 2410.6ELANE, LTA
9lead449.6ITGA4, TTF2
10carbon449.5ELANE, TTF2
11endotoxin449.5LTA, ELANE
12doxycycline44 1110.5ELANE, TGIF1
13nicotine44 28 50 1112.4ELANE, TTF2
141,25 dihydroxy vitamin d3449.4TTF2, TGIF1
15tgf beta1449.4LTA, TGIF1
16cyclosporin a44 28 6111.4LTA, ELANE, TTF2
17pentoxifylline44 1110.3LTA, ITGA4, ELANE
18fmlp449.3LTA, ITGA4, ELANE
19cytochalasin d44 6110.2ITGA4, TGIF1
20fibrinogen449.2ITGA4, ELANE, TTF2
21pge2449.1LTA, ELANE, TGIF1
22lactate449.1TGIF1, ELANE, LTA
23progesterone44 28 61 24 1113.0LTA, TGIF1, TTF2
24h2o2449.0LTA, ELANE, TGIF1
25cholesterol44 28 24 1112.0TTF2, TGIF1, LTA
26steroid449.0LTA, TGIF1, TTF2
27vegf449.0LTA, TGIF1, TTF2
28threonine448.9TTF2, TGIF1, LTA
29cyclic amp44 249.9LTA, ITGA4, TGIF1
30glutamate448.9TGIF1, ELANE, LTA
31vitamin d448.6LTA, ELANE, TGIF1, TTF2
32glucose448.6LTA, ITGA4, TTF2
33estrogen448.6LTA, ELANE, TGIF1, TTF2
34cysteine448.5TTF2, TGIF1, ELANE
35dexamethasone44 50 28 1111.5TTF2, TGIF1, ITGA4, LTA
36nitric oxide44 24 1110.5TTF2, TGIF1, ITGA4, LTA
37retinoic acid44 249.5TGIF1, ELANE, ITGA4, LTA
38heparin44 28 24 1111.4TTF2, TGIF1, ELANE, ITGA4
39calcium44 50 24 1111.3LTA, ITGA4, TGIF1, TTF2
40oxygen44 249.0TTF2, TGIF1, ELANE, ITGA4, LTA
41serine447.9LTA, ITGA4, ELANE, TGIF1, TTF2

GO Terms for genes affiliated with Chronic Venous Leg Ulcers

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Biological processes related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.5LTA, ELANE
2negative regulation of growth of symbiont in hostGO:0441309.4LTA, ELANE
3leukocyte migrationGO:0509009.0ITGA4, ELANE

Molecular functions related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.6NFKBIL1, ITGA4, ELANE, TGIF1, TTF2

Products for genes affiliated with Chronic Venous Leg Ulcers

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  • Antibodies
  • Proteins
  • Lysates

Sources for Chronic Venous Leg Ulcers

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet