MCID: CHR415
MIFTS: 35

Chronic Venous Leg Ulcers malady

Summaries for Chronic Venous Leg Ulcers

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MalaCards based summary: Chronic Venous Leg Ulcers, also known as chronic ulcer of lower extremity, is related to atopic dermatitis and blindness. An important gene associated with Chronic Venous Leg Ulcers is NFKBIL1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1). The compounds neopterin and p003 have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and testes, and related mouse phenotype immune system.

Aliases & Classifications for Chronic Venous Leg Ulcers

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Sources:
32LifeMap Discovery®, 45Novoseek, 62UMLS
See all sources

Chronic Venous Leg Ulcers, Aliases & Descriptions:

Name: Chronic Venous Leg Ulcers 32 45
 
Chronic Ulcer of Lower Extremity 62


Related Diseases for Chronic Venous Leg Ulcers

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Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis30.4LTA, TTF2
2blindness10.5
3chronic venous insufficiency10.4
4thrombophilia10.4
5venous insufficiency10.4
6hemochromatosis10.3
7reflex sympathetic dystrophy10.3
8post-thrombotic syndrome10.3
9dermatitis10.3
10acute respiratory distress syndrome10.0LTA, ELANE
11periodontitis10.0LTA, ELANE
12hypertriglyceridemia10.0LTA, TTF2
13pulmonary sarcoidosis10.0LTA, ITGA4
14uveitis10.0LTA, ITGA4
15nephritis10.0LTA, ITGA4
16coronary artery disease10.0LTA, TTF2
17allergic asthma10.0ITGA4, LTA
18vasculitis10.0ELANE, ITGA4
19chronic lymphocytic leukemia10.0ITGA4, LTA
20duodenal ulcer10.0LTA, TGIF1
21hypercalcemia10.0LTA, TGIF1
22hepatitis10.0LTA, TTF2
23pneumonia10.0ITGA4, ELANE
24sarcoidosis 110.0LTA, TGIF1
25pulmonary fibrosis10.0TGIF1, ELANE
26non-suppurative otitis media10.0ITGA4, TGIF1
27t-cell leukemia10.0LTA, ITGA4, TTF2
28arthritis10.0LTA, ITGA4, TTF2
29herpes simplex10.0TTF2, TGIF1
30hodgkin lymphoma10.0TGIF1, ITGA4, LTA
31ipex syndrome10.0TTF2, TGIF1, LTA
32astrocytoma10.0TGIF1, ITGA4, LTA
33primary hyperoxaluria10.0TGIF1, ITGA4, LTA
34glomerulonephritis10.0ITGA4, ELANE, TGIF1
35liver cirrhosis10.0TTF2, TGIF1
36prostate cancer10.0TTF2, TGIF1, LTA
37leukemia9.9LTA, ITGA4, TGIF1
38myeloid leukemia9.9LTA, ELANE, TGIF1, TTF2
39rheumatoid arthritis9.9LTA, ITGA4, ELANE, TGIF1
40ulcerative colitis9.9TGIF1, ELANE, ITGA4, LTA
41inflammatory bowel disease9.9TGIF1, ELANE, ITGA4, LTA
42psoriasis9.9TGIF1, ELANE, ITGA4, LTA
43gastric cancer, somatic9.9TTF2, TGIF1, ITGA4, LTA
44asthma9.9TTF2, TGIF1, ELANE, ITGA4

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to chronic venous leg ulcers

Symptoms for Chronic Venous Leg Ulcers

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Drugs & Therapeutics for Chronic Venous Leg Ulcers

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Drug clinical trials:

Search ClinicalTrials for Chronic Venous Leg Ulcers

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf, PMIDs: 12055943, 12463767, 20849380, 18615798

Genetic Tests for Chronic Venous Leg Ulcers

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Anatomical Context for Chronic Venous Leg Ulcers

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MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

33
Skin, Neutrophil, Testes

Animal Models for Chronic Venous Leg Ulcers or affiliated genes

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MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1LTA, ITGA4, ELANE, TGIF1

Publications for Chronic Venous Leg Ulcers

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Articles related to Chronic Venous Leg Ulcers:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
The impact of chronic venous leg ulcers: a systematic review. (25492276)
2014
2
Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings. (24589044)
2014
3
Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. (24839984)
2014
4
Chronic venous leg ulcers: Effects of foam sclerotherapy on healing and recurrence. (25351907)
2014
5
Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. (24635169)
2014
6
A topical haemoglobin spray for oxygenating chronic venous leg ulcers: a pilot study. (25382133)
2014
7
Maggots as a wound debridement agent for chronic venous leg ulcers under graduated compression bandages: a randomised controlled trial. (25300315)
2014
8
Cost-effectiveness of three adjunct cellular/tissue-derived products used in the management of chronic venous leg ulcers. (25498775)
2014
9
Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers. (23998779)
2013
10
Neutrophil activity in chronic venous leg ulcers--a target for therapy? (23551462)
2013
11
Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. (23531093)
2013
12
Catheter-directed foam sclerotherapy for chronic venous leg ulcers. (24072751)
2013
13
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. (22174074)
2012
14
Chronic venous leg ulcers: the future of cell-based therapies. (22863327)
2012
15
Duration of wound fluid secretion from chronic venous leg ulcers is critical for interleukin-1I+, interleukin-1I^, interleukin-8 levels and fibroblast activation. (21786164)
2011
16
Insufficient and incomplete shaving in chronic venous leg ulcers leads to a poor prognosis of the skin graft: a histomorphological analysis. (21893960)
2011
17
Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or without postthrombotic syndrome. (21362083)
2011
18
Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. (20558044)
2010
19
Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? (21472223)
2010
20
Managing chronic venous leg ulcers: time for a new approach? (20216491)
2010
21
Why do chronic venous leg ulcers not heal? (19287249)
2009
22
The use of sensory nerve stimulation and compression bandaging to improve sensory nerve function and healing of chronic venous leg ulcers. (20021401)
2009
23
Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier. (18384617)
2008
24
Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*. (18336381)
2008
25
Evaluation of apoptotic cells and immunohistochemical detection of FAS, FAS-L, Bcl-2, Bax, p53 and c-Myc in the skin of patients with chronic venous leg ulcers. (18813857)
2008
26
An exploration of the use of ultrasound in the treatment of chronic venous leg ulcers. (16669305)
2006
27
Chronic venous leg ulcers benefit from surgery: long-term results from 173 legs. (16950436)
2006
28
Chronic venous leg ulcers: effect of a community nursing intervention on pain and healing. (16163986)
2005
29
Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. (16286373)
2005
30
Risk factors for delayed healing and recurrence of chronic venous leg ulcers--an analysis of 1324 legs. (15570275)
2005
31
Oxidative stress in chronic venous leg ulcers. (16176453)
2005
32
Improved healing rates for chronic venous leg ulcers: pilot study results from a randomized controlled trial of a community nursing intervention. (15985095)
2005
33
Successful treatment of chronic venous leg ulcers with lyophilized cultured epidermal allografts. (15818446)
2004
34
Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension. (15453833)
2004
35
Autologous cultured keratinocytes on porcine gelatin microbeads effectively heal chronic venous leg ulcers. (15086765)
2004
36
Sensory testing in patients with chronic venous leg ulcers using a 10 g Owen Mumford monofilament. (12838598)
2003
37
Cytokines and growth factors in keratinocytes and sweat glands in chronic venous leg ulcers. An immunohistochemical study. (12950634)
2003
38
The prevalence of thrombophilia in patients with chronic venous leg ulceration. (11932669)
2002
39
Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers. (11710945)
2001
40
Living with chronic venous leg ulcers: a descriptive study of knowledge and functional health status. (10778025)
2000
41
Expression of tissue-type and urokinase-type plasminogen activator activities in chronic venous leg ulcers. (10409920)
1999
42
Randomized, double-blind, placebo-controlled, dose- ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers. (10231502)
1999
43
Trial of two bandaging systems for chronic venous leg ulcers. (9325829)
1997
44
Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation. (9314951)
1997
45
Activated protein C resistance caused by factor V gene mutation: common coagulation defect in chronic venous leg ulcers? (9092749)
1997
46
Colour duplex ultrasonography in the rational management of chronic venous leg ulcers. (8944433)
1996
47
Cytokine and protease levels in healing and non-healing chronic venous leg ulcers. (8608341)
1995
48
The effect of aspirin on haemostatic activity in the treatment of chronic venous leg ulceration. (7718459)
1995
49
Abnormal lymph drainage in patients with chronic venous leg ulcers. (8463459)
1993
50
Diurnal variations in lower leg subcutaneous blood flow rate in patients with chronic venous leg ulcers. (1751349)
1991

Variations for Chronic Venous Leg Ulcers

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Expression for genes affiliated with Chronic Venous Leg Ulcers

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Search GEO for disease gene expression data for Chronic Venous Leg Ulcers.

Pathways for genes affiliated with Chronic Venous Leg Ulcers

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Compounds for genes affiliated with Chronic Venous Leg Ulcers

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Compounds related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1neopterin459.8ELANE, LTA
2p003459.8LTA, TTF2
3phorbol 12,13-dibutyrate459.8ITGA4, LTA
4infliximab45 51 1311.8LTA, ITGA4
5ivig459.8ITGA4, LTA
6methacholine45 51 1311.7ITGA4, TTF2
7thyroxine45 2610.6LTA, ELANE
8hyaluronic acid45 2610.6ELANE, LTA
9lead459.6ITGA4, TTF2
10carbon459.5ELANE, TTF2
11endotoxin459.5LTA, ELANE
12doxycycline45 1310.5ELANE, TGIF1
13nicotine45 30 51 1312.4ELANE, TTF2
141,25 dihydroxy vitamin d3459.4TTF2, TGIF1
15tgf beta1459.4LTA, TGIF1
16cyclosporin a45 30 6111.4LTA, ELANE, TTF2
17pentoxifylline45 1310.3LTA, ITGA4, ELANE
18fmlp459.3LTA, ITGA4, ELANE
19cytochalasin d45 6110.2ITGA4, TGIF1
20fibrinogen459.2ITGA4, ELANE, TTF2
21pge2459.1LTA, ELANE, TGIF1
22lactate459.1TGIF1, ELANE, LTA
23progesterone45 30 61 26 1313.0LTA, TGIF1, TTF2
24h2o2459.0LTA, ELANE, TGIF1
25cholesterol45 30 26 1312.0TTF2, TGIF1, LTA
26steroid459.0LTA, TGIF1, TTF2
27vegf459.0LTA, TGIF1, TTF2
28threonine458.9TTF2, TGIF1, LTA
29cyclic amp45 269.9LTA, ITGA4, TGIF1
30glutamate458.9TGIF1, ELANE, LTA
31vitamin d458.6LTA, ELANE, TGIF1, TTF2
32glucose458.6LTA, ITGA4, TTF2
33estrogen458.6LTA, ELANE, TGIF1, TTF2
34cysteine458.5TTF2, TGIF1, ELANE
35dexamethasone45 51 30 1311.5TTF2, TGIF1, ITGA4, LTA
36nitric oxide45 26 1310.5TTF2, TGIF1, ITGA4, LTA
37retinoic acid45 269.5TGIF1, ELANE, ITGA4, LTA
38heparin45 30 26 1311.4TTF2, TGIF1, ELANE, ITGA4
39calcium45 51 26 1311.3LTA, ITGA4, TGIF1, TTF2
40oxygen45 269.0TTF2, TGIF1, ELANE, ITGA4, LTA
41serine457.9LTA, ITGA4, ELANE, TGIF1, TTF2

GO Terms for genes affiliated with Chronic Venous Leg Ulcers

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Biological processes related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:00324969.5LTA, ELANE
2negative regulation of growth of symbiont in hostGO:00441309.4LTA, ELANE
3leukocyte migrationGO:00509009.0ITGA4, ELANE

Molecular functions related to Chronic Venous Leg Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.6NFKBIL1, ITGA4, ELANE, TGIF1, TTF2

Products for genes affiliated with Chronic Venous Leg Ulcers

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Sources for Chronic Venous Leg Ulcers

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet