Aliases & Classifications for Chronic Wasting Disease

MalaCards integrated aliases for Chronic Wasting Disease:

Name: Chronic Wasting Disease 12 3 14
Wasting Disease, Chronic 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3530
MeSH 41 D034081
UMLS 69 C1135993

Summaries for Chronic Wasting Disease

MalaCards based summary : Chronic Wasting Disease, also known as wasting disease, chronic, is related to scrapie and kuru, and has symptoms including lameness, animal An important gene associated with Chronic Wasting Disease is PRNP (Prion Protein), and among its related pathways/superpathways are Complement and coagulation cascades and Immune response Lectin induced complement pathway. The drugs Caseins and Soy Bean have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and tonsil.

Wikipedia : 72 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of mule deer,... more...

Related Diseases for Chronic Wasting Disease

Diseases related to Chronic Wasting Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 scrapie 31.2 PRNP SPRN
2 kuru 30.9 ERC1 PRNP
3 prion disease 30.8 CR2 PRNP SPRN
4 creutzfeldt-jakob disease 28.9 PRNP SPRN
5 genetic prion diseases 10.8
6 encephalopathy 10.2
7 mucositis 10.0
8 aging 9.9
9 dermal ridges-off-the-end 9.8
10 tonsillitis 9.8
11 mycobacterium tuberculosis 1 9.7
12 lymphocytic choriomeningitis 9.7
13 parasitic ectoparasitic infectious disease 9.7
14 lupus erythematosus 9.6 C1QC CR2

Graphical network of the top 20 diseases related to Chronic Wasting Disease:



Diseases related to Chronic Wasting Disease

Symptoms & Phenotypes for Chronic Wasting Disease

UMLS symptoms related to Chronic Wasting Disease:


lameness, animal

Drugs & Therapeutics for Chronic Wasting Disease

Drugs for Chronic Wasting Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Caseins
2 Soy Bean Nutraceutical
3 Whey Protein Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Active, not recruiting NCT02072057 Phase 2 Ruxolitinib
2 Disturbances in BCAA Metabolism and the Effects of Feeding and Exercise in COPD Completed NCT01418469
3 Sarcopenia and Visceral Obesity in Esophageal and Gastric Cancer Active, not recruiting NCT03061370

Search NIH Clinical Center for Chronic Wasting Disease

Cochrane evidence based reviews: wasting disease, chronic

Genetic Tests for Chronic Wasting Disease

Anatomical Context for Chronic Wasting Disease

MalaCards organs/tissues related to Chronic Wasting Disease:

38
Brain, Testes, Tonsil, Lymph Node, Skeletal Muscle, B Cells, Retina

Publications for Chronic Wasting Disease

Articles related to Chronic Wasting Disease:

(show top 50) (show all 268)
# Title Authors Year
1
Chronic wasting disease management in ranched elk using rectal biopsy testing. ( 29424295 )
2018
2
Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling. ( 29118163 )
2018
3
High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population. ( 28350512 )
2017
4
Current evidence on the transmissibility of chronic wasting disease prions to humans-A systematic review. ( 28139079 )
2017
5
Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (Cervus elaphus nelsoni) using real-time quaking-induced conversion (RT-QuIC) assay: A blinded collaborative study. ( 29098931 )
2017
6
Pathways of Prion Spread during Early Chronic Wasting Disease in Deer. ( 28250130 )
2017
7
Temporal patterns of chronic wasting disease prion excretion in three cervid species. ( 28708047 )
2017
8
Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice. ( 29105545 )
2017
9
Induction of PrP<sup>Sc</sup>-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease. ( 28968152 )
2017
10
Chronic wasting disease prion infection of differentiated neurospheres. ( 28762865 )
2017
11
Detection of Prions in Blood of Cervids at the Asymptomatic Stage of Chronic Wasting Disease. ( 29222449 )
2017
12
Pathogen-mediated selection in free-ranging elk populations infected by chronic wasting disease. ( 29087314 )
2017
13
Detection of chronic wasting disease prion seeding activity in deer and elk feces by real-time quaking-induced conversion. ( 28703697 )
2017
14
Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro. ( 28874781 )
2017
15
Experimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation. ( 28701407 )
2017
16
Infectious Prions in the Pregnancy Microenvironment of Chronic Wasting Disease-Infected Reeves' Muntjac Deer. ( 28539446 )
2017
17
EFSA proposes surveillance scheme for chronic wasting disease. ( 28154211 )
2017
18
Molecular Mechanisms of Chronic Wasting Disease Prion Propagation. ( 28193766 )
2017
19
Endemic chronic wasting disease causes mule deer population decline in Wyoming. ( 29049389 )
2017
20
Contact tracing for the control of infectious disease epidemics: Chronic Wasting Disease in deer farms. ( 29329958 )
2017
21
Evolution of Diagnostic Tests for Chronic Wasting Disease, a Naturally Occurring Prion Disease of Cervids. ( 28783058 )
2017
22
Clay content and pH: soil characteristic associations with the persistent presence of chronic wasting disease in northern Illinois. ( 29273783 )
2017
23
Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion. ( 29058651 )
2017
24
Chronic wasting disease: Emerging prions and their potential risk. ( 29095921 )
2017
25
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion. ( 28820384 )
2017
26
Applications of mathematical modeling in managing the spread of chronic wasting disease (CWD) in wild deer under alternative harvesting scenarios. ( 27556563 )
2016
27
Intra-host mathematical model of chronic wasting disease dynamics in deer (Odocoileus). ( 27537196 )
2016
28
Systematic review of management strategies to control chronic wasting disease in wild deer populations in North America. ( 27549119 )
2016
29
Seeded Amplification of Chronic Wasting Disease Prions in Nasal Brushings and Recto-anal Mucosa-Associated Lymphoid Tissues from Elk by Real-Time Quaking-Induced Conversion. ( 26888899 )
2016
30
Modeled Impacts of Chronic Wasting Disease on White-Tailed Deer in a Semi-Arid Environment. ( 27711208 )
2016
31
Dietary Magnesium and Copper Affect Survival Time and Neuroinflammation in Chronic Wasting Disease. ( 27216881 )
2016
32
First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer. ( 27641251 )
2016
33
Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle. ( 27031704 )
2016
34
Horizontal Transmission of Chronic Wasting Disease in Reindeer. ( 27869594 )
2016
35
Using expert judgments to improve chronic wasting disease risk management in Canada. ( 27556565 )
2016
36
Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion. ( 27829062 )
2016
37
Chronic Wasting Disease Drives Population Decline of White-Tailed Deer. ( 27575545 )
2016
38
Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein. ( 27393736 )
2016
39
Chronic wasting disease of deer - is the battle to keep Europe free already lost? ( 27474059 )
2016
40
Expert elicitation on the uncertainties associated with chronic wasting disease. ( 27556566 )
2016
41
Chronic wasting disease in white-tailed deer: infection, mortality, and implications for heterogeneous transmission. ( 27870037 )
2016
42
Chronic Wasting Disease: Transmission Mechanisms and the Possibility of Harvest Management. ( 26963921 )
2016
43
Antemortem Detection of Chronic Wasting Disease Prions in Nasal Brush Collections and Rectal Biopsy Specimens from White-Tailed Deer by Real-Time Quaking-Induced Conversion. ( 26865693 )
2016
44
Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice. ( 26116725 )
2015
45
Aggregation and environmental transmission in chronic wasting disease. ( 25811337 )
2015
46
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains. ( 26423950 )
2015
47
Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion. ( 26157118 )
2015
48
Progressive accumulation of the abnormal conformer of the prion protein and spongiform encephalopathy in the obex of nonsymptomatic and symptomatic Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease. ( 26185123 )
2015
49
Longitudinal Detection of Prion Shedding in Saliva and Urine by Chronic Wasting Disease-Infected Deer by Real-Time Quaking-Induced Conversion. ( 26136567 )
2015
50
Prion protein gene sequence and chronic wasting disease susceptibility in white-tailed deer (Odocoileus virginianus). ( 26634768 )
2015

Variations for Chronic Wasting Disease

Expression for Chronic Wasting Disease

Search GEO for disease gene expression data for Chronic Wasting Disease.

Pathways for Chronic Wasting Disease

GO Terms for Chronic Wasting Disease

Cellular components related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of membrane GO:0031225 8.62 PRNP SPRN

Biological processes related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement activation, classical pathway GO:0006958 8.96 C1QC CR2
2 regulation of complement activation GO:0030449 8.62 C1QC CR2

Sources for Chronic Wasting Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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