MCID: CHR028
MIFTS: 34

Chronic Wasting Disease malady

Categories: Neuronal diseases

Aliases & Classifications for Chronic Wasting Disease

Aliases & Descriptions for Chronic Wasting Disease:

Name: Chronic Wasting Disease 12 3 14
Wasting Disease, Chronic 42

Classifications:



External Ids:

Disease Ontology 12 DOID:3530
MeSH 42 D034081
UMLS 69 C1135993

Summaries for Chronic Wasting Disease

CDC : 3 The known natural hosts of CWD are mule deer, white-tailed deer, elk, and moose.

MalaCards based summary : Chronic Wasting Disease, also known as wasting disease, chronic, is related to scrapie and encephalopathy. An important gene associated with Chronic Wasting Disease is PRNP (Prion Protein), and among its related pathways/superpathways are Complement and coagulation cascades and Immune response Lectin induced complement pathway. The drugs Fosinopril and Irbesartan have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node.

Wikipedia : 71 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of mule deer,... more...

Related Diseases for Chronic Wasting Disease

Diseases related to Chronic Wasting Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 scrapie 10.2
2 encephalopathy 10.1
3 prion disease 10.1
4 diabetes insipidus, neurohypophyseal 9.9 ERC1 PRNP
5 prion disease with protracted course 9.9 PRNP SPRN
6 mucositis 9.8
7 tonsillitis 9.8
8 syringocystadenoma papilliferum 9.7 PRNP SPRN
9 vaginal spindle cell epithelioma 9.7 CR2 PRNP SPRN
10 creutzfeldt-jakob disease 9.6
11 lymphocytic choriomeningitis 9.6
12 tuberculosis 9.6
13 adult choroid plexus cancer 9.2 C1QC CR2 ERC1 PRNP SPRN

Graphical network of the top 20 diseases related to Chronic Wasting Disease:



Diseases related to Chronic Wasting Disease

Symptoms & Phenotypes for Chronic Wasting Disease

Drugs & Therapeutics for Chronic Wasting Disease

Drugs for Chronic Wasting Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 137)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fosinopril Approved Phase 4 98048-97-6 55891
2
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
3 Angiotensin-Converting Enzyme Inhibitors Phase 4
4 Antihypertensive Agents Phase 4
5 HIV Protease Inhibitors Phase 4
6
protease inhibitors Phase 4
7 insulin Phase 4,Phase 2
8 Insulin, Globin Zinc Phase 4,Phase 2
9
Angiotensin II Phase 4 68521-88-0, 11128-99-7 65143 172198
10 Angiotensin II Type 1 Receptor Blockers Phase 4
11 Angiotensin Receptor Antagonists Phase 4
12 Angiotensinogen Phase 4
13 Hypoglycemic Agents Phase 4
14 Cystatins Phase 4
15 cysteine Nutraceutical Phase 4
16
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
17
Methyltestosterone Approved Phase 3 58-18-4 6010
18
Testosterone Approved, Investigational Phase 3 58-22-0 6013
19
Anagrelide Approved Phase 3 68475-42-3 2182
20
Busulfan Approved, Investigational Phase 3 55-98-1 2478
21
Hydroxyurea Approved Phase 3 127-07-1 3657
22 Hormone Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
23 Hormones Phase 3,Phase 2,Phase 1,Early Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
25 Anti-Inflammatory Agents Phase 3,Phase 2
26 Antioxidants Phase 3
27 Chelating Agents Phase 3
28 Phosphodiesterase Inhibitors Phase 3
29 Platelet Aggregation Inhibitors Phase 3
30 Protective Agents Phase 3,Phase 2
31 Radiation-Protective Agents Phase 3
32 Vasodilator Agents Phase 3
33 Androgens Phase 3,Phase 1
34 Testosterone 17 beta-cypionate Phase 3
35
Testosterone enanthate Phase 3 315-37-7 9416
36 Testosterone undecanoate Phase 3
37 Adjuvants, Immunologic Phase 3
38 interferons Phase 3
39 Nucleic Acid Synthesis Inhibitors Phase 3
40 Pharmaceutical Solutions Phase 2, Phase 3
41 Omega 3 Fatty Acid Nutraceutical Phase 3,Phase 1,Phase 2
42 tyrosine Nutraceutical Phase 3
43 leucine Nutraceutical Phase 2, Phase 3
44 beta-Hydroxy-beta-methylbutyrate Nutraceutical Phase 2, Phase 3
45
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337
46
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
47
Cyproheptadine Approved Phase 2 129-03-3 2913
48
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
49
Megestrol acetate Approved, Vet_approved Phase 2 595-33-5 11683
50
Dopamine Approved Phase 2 51-61-6, 62-31-7 681

Interventional clinical trials:

(show top 50) (show all 98)
id Name Status NCT ID Phase
1 Angiotensin-converting Enzyme (ACE)-Inhibition and Mechanisms of Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01014338 Phase 4
2 TENS in Optimizer(R) Patients Completed NCT02692690 Phase 4
3 Effect of Irbesartan on Insulin Sensitivity in Chronic Heart Failure Completed NCT00347087 Phase 4
4 Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients Completed NCT01935388 Phase 4
5 Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS Recruiting NCT02276066 Phase 4
6 Body Composition Measurements in Chronic Heart Failure Recruiting NCT02686866 Phase 4
7 LPD+α-ketoacids on Autophagy and Improving Muscle Wasting in CKD Not yet recruiting NCT02568020 Phase 4
8 Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2) Completed NCT01387282 Phase 3
9 Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 1) Completed NCT01387269 Phase 3
10 Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3) Completed NCT01395914 Phase 3
11 Anit-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients Completed NCT00561093 Phase 3
12 Multimodal Therapeutic Approach in Undernourished Maintenance Hemodialysis Patients (AMERICANO) Recruiting NCT02418065 Phase 3
13 The Ruxo-BEAT Trial in Patients With High-risk Polycythemia Vera or High-risk Essential Thrombocythemia Recruiting NCT02577926 Phase 3
14 Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit Not yet recruiting NCT02773771 Phase 2, Phase 3
15 Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis Not yet recruiting NCT02976688 Phase 2, Phase 3
16 Protein-energy Oral Supplementation Enriched With Omega-3 Fatty Acids in Cardiac Cachexia Terminated NCT00748332 Phase 3
17 BYM338 in Chronic Obstructive Pulmonary Disease (COPD) Patients With Cachexia Completed NCT01669174 Phase 2
18 SUN11031 in Cachexia Associated With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT00698828 Phase 2
19 Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in COPD Cachexia Completed NCT02442908 Phase 1, Phase 2
20 A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss Completed NCT00094562 Phase 2
21 Enteral Nutrition in Congestive Heart Failure and Cardiac Cachexia Completed NCT00654719 Phase 2
22 Nutrition, Inflammation and Insulin Resistance in End Stage Renal Disease-Aim 2 Completed NCT02278562 Phase 2
23 Effects of PINTA 745 in End Stage Renal Disease (ESRD) Patients Who Require Hemodialysis and Have Protein Energy Wasting Completed NCT01958970 Phase 1, Phase 2
24 The Effects of Thalidomide on Symptom Clusters Completed NCT00379353 Phase 2
25 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2
26 Musculoskeletal Effects of Bicarbonate Completed NCT01475214 Phase 2
27 Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS) Completed NCT00942253 Phase 2
28 Study of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Active, not recruiting NCT02072057 Phase 2
29 Haelan and Nutrition in Cancer Patients Terminated NCT00558558 Phase 2
30 Efficacy and Safety Study of Tesamorelin in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Muscle Wasting Terminated NCT01388920 Phase 2
31 The Role of the "Inflammatory/ Pathogen Burden" for Cardiac Ageing Terminated NCT01045512 Phase 2
32 Pilot Study of the Safety and Efficacy of Oxandrolone in the Prevention and Treatment of Malnutrition in Infants Active, not recruiting NCT01048632 Phase 1
33 Malnutrition, Diet and Racial Disparities in Chronic Kidney Disease (CKD) Unknown status NCT01415570
34 Impact of Body Composition on Bisoprolol and Ramipril Pharmacokinetics in Patients With Chronic Heart Failure Unknown status NCT01829880
35 The Effect of Two Weeks of Voluntary Reduced Physical Activity in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT02221804
36 The Roles of Cytokines in the Mechanism of Insulin Resistance and Energy Balance Unknown status NCT00172614
37 Effects of Growth Hormone in Chronically Ill Children Unknown status NCT00286689
38 Disturbances in BCAA Metabolism and the Effects of Feeding and Exercise in COPD Completed NCT01418469
39 Wasting in Chronic Kidney Disease Completed NCT03135717
40 A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition Completed NCT01179178
41 Body Composition in Preschool Children Completed NCT01920724
42 Inflammation, Proteolysis and IL-1 Beta Receptor Inhibition in Chronic Hemodialysis Patients Completed NCT00420290
43 Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Chronic Heart Failure and Chronic Obstructive Pulmonary Disease Patients Completed NCT00852020
44 Efficacy of Serum Bovine Immunoglobulin in Improving Nutritional Status in Advanced COPD Completed NCT02067377
45 An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis Completed NCT02452073
46 Ghrelin and Obestatin in CKD Children Completed NCT03171116
47 The Effect of Neuromuscular Electrical Stimulation Completed NCT00442728
48 Peroral Supplemental Nutrition in End-stage Renal Disease With and Without HIV Comorbidity Completed NCT00687050
49 Adipose Tissue & Uremia Completed NCT02902705
50 Testosterone Replacement Therapy in Advanced Chronic Kidney Disease Completed NCT00645658

Search NIH Clinical Center for Chronic Wasting Disease

Cochrane evidence based reviews: wasting disease, chronic

Genetic Tests for Chronic Wasting Disease

Anatomical Context for Chronic Wasting Disease

MalaCards organs/tissues related to Chronic Wasting Disease:

39
Brain, Testes, Lymph Node, Skeletal Muscle, Tonsil, B Cells, Retina

Publications for Chronic Wasting Disease

Articles related to Chronic Wasting Disease:

(show top 50) (show all 243)
id Title Authors Year
1
Using expert judgments to improve chronic wasting disease risk management in Canada. ( 27556565 )
2016
2
Applications of mathematical modeling in managing the spread of chronic wasting disease (CWD) in wild deer under alternative harvesting scenarios. ( 27556563 )
2016
3
Horizontal Transmission of Chronic Wasting Disease in Reindeer. ( 27869594 )
2016
4
Chronic wasting disease of deer - is the battle to keep Europe free already lost? ( 27474059 )
2016
5
Dietary Magnesium and Copper Affect Survival Time and Neuroinflammation in Chronic Wasting Disease. ( 27216881 )
2016
6
Expert elicitation on the uncertainties associated with chronic wasting disease. ( 27556566 )
2016
7
Chronic wasting disease in white-tailed deer: infection, mortality, and implications for heterogeneous transmission. ( 27870037 )
2016
8
Intra-host mathematical model of chronic wasting disease dynamics in deer (Odocoileus). ( 27537196 )
2016
9
Chronic Wasting Disease Drives Population Decline of White-Tailed Deer. ( 27575545 )
2016
10
Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle. ( 27031704 )
2016
11
Chronic Wasting Disease: Transmission Mechanisms and the Possibility of Harvest Management. ( 26963921 )
2016
12
Seeded Amplification of Chronic Wasting Disease Prions in Nasal Brushings and Recto-anal Mucosa-Associated Lymphoid Tissues from Elk by Real-Time Quaking-Induced Conversion. ( 26888899 )
2016
13
Systematic review of management strategies to control chronic wasting disease in wild deer populations in North America. ( 27549119 )
2016
14
Modeled Impacts of Chronic Wasting Disease on White-Tailed Deer in a Semi-Arid Environment. ( 27711208 )
2016
15
Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion. ( 27829062 )
2016
16
Antemortem Detection of Chronic Wasting Disease Prions in Nasal Brush Collections and Rectal Biopsy Specimens from White-Tailed Deer by Real-Time Quaking-Induced Conversion. ( 26865693 )
2016
17
First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer. ( 27641251 )
2016
18
Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein. ( 27393736 )
2016
19
Progressive accumulation of the abnormal conformer of the prion protein and spongiform encephalopathy in the obex of nonsymptomatic and symptomatic Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease. ( 26185123 )
2015
20
Prion protein gene sequence and chronic wasting disease susceptibility in white-tailed deer (Odocoileus virginianus). ( 26634768 )
2015
21
Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice. ( 26116725 )
2015
22
Aggregation and environmental transmission in chronic wasting disease. ( 25811337 )
2015
23
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains. ( 26423950 )
2015
24
Longitudinal Detection of Prion Shedding in Saliva and Urine by Chronic Wasting Disease-Infected Deer by Real-Time Quaking-Induced Conversion. ( 26136567 )
2015
25
Empirical Estimation of R0 for Unknown Transmission Functions: The Case of Chronic Wasting Disease in Alberta. ( 26452231 )
2015
26
Human prion protein sequence elements impede cross-species chronic wasting disease transmission. ( 25961458 )
2015
27
Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion. ( 26157118 )
2015
28
Human prion protein sequence elements impede cross-species chronic wasting disease transmission. ( 25705888 )
2015
29
Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease. ( 25539804 )
2015
30
In utero transmission and tissue distribution of chronic wasting disease-associated prions in free-ranging Rocky Mountain elk. ( 26358706 )
2015
31
Detection of chronic wasting disease in the lymph nodes of free-ranging cervids by real-time quaking-induced conversion. ( 24958799 )
2014
32
Chronic Wasting Disease of Cervids: Current Knowledge and Future Perspectives. ( 25387112 )
2014
33
Modeling seasonal behavior changes and disease transmission with application to chronic wasting disease. ( 24035840 )
2014
34
Can plants serve as a vector for prions causing chronic wasting disease? ( 24509640 )
2014
35
Transmission of chronic wasting disease in Wisconsin white-tailed deer: implications for disease spread and management. ( 24658535 )
2014
36
Chronic wasting disease agents in nonhuman primates. ( 24751215 )
2014
37
Quinacrine promotes replication and conformational mutation of chronic wasting disease prions. ( 24711410 )
2014
38
In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate. ( 25495764 )
2014
39
Lesion Profiling and Subcellular Prion Localization of Cervid Chronic Wasting Disease in Domestic Cats. ( 24577721 )
2014
40
"Atypical" chronic wasting disease in PRNP genotype 225FF mule deer. ( 24807352 )
2014
41
The importance of localized culling in stabilizing chronic wasting disease prevalence in white-tailed deer populations. ( 24128754 )
2014
42
Immunization with a synthetic peptide vaccine fails to protect mule deer (Odocoileus hemionus) from chronic wasting disease. ( 23778624 )
2013
43
Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay. ( 23764839 )
2013
44
Efficacy of antemortem rectal biopsies to diagnose and estimate prevalence of chronic wasting disease in free-ranging cow elk (Cervus elaphus nelsoni). ( 23568902 )
2013
45
Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases. ( 23505374 )
2013
46
Influence of landscape factors and management decisions on spatial and temporal patterns of the transmission of chronic wasting disease transmission in white-tailed deer. ( 24258897 )
2013
47
Evaluation of a wild white-tailed deer population management program for controlling chronic wasting disease in Illinois, 2003-2008. ( 23558033 )
2013
48
Homogenization, sex, and differential motility predict spread of chronic wasting disease in mule deer in southern Utah. ( 23846241 )
2013
49
Mother to offspring transmission of chronic wasting disease in reeves' muntjac deer. ( 23977159 )
2013
50
Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay. ( 23671598 )
2013

Variations for Chronic Wasting Disease

Expression for Chronic Wasting Disease

Search GEO for disease gene expression data for Chronic Wasting Disease.

Pathways for Chronic Wasting Disease

GO Terms for Chronic Wasting Disease

Cellular components related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 anchored component of membrane GO:0031225 8.62 PRNP SPRN

Biological processes related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 complement activation, classical pathway GO:0006958 8.96 C1QC CR2
2 regulation of complement activation GO:0030449 8.62 C1QC CR2

Sources for Chronic Wasting Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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