MCID: CHR001
MIFTS: 56

Churg-Strauss Syndrome malady

Rare diseases, Immune diseases, Cardiovascular diseases categories

Summaries for Churg-Strauss Syndrome

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NIH Rare Diseases:43 Churg strauss syndrome is a condition characterized by asthma, high levels of eosinophils (a type of white blood cell that helps fight infection), and inflammation of small to medium sized blood vessels (vasculitis). the inflamed vessels can affect various organ systems including the lungs, gastrointestinal tract, skin, heart and nervous system. the exact cause of churg strauss syndrome is unknown, but it is thought to be an autoimmune disorder. treatment may involve the use of glucocorticoids and/or other immunosuppressive therapies. last updated: 3/9/2015

MalaCards based summary: Churg-Strauss Syndrome, also known as eosinophilic granulomatous vasculitis, is related to asthma and vasculitis, and has symptoms including asthma An important gene associated with Churg-Strauss Syndrome is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Selected targets of GCR alpha and IL4-mediated signaling events. The compounds mometasone furoate and unicap have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and skin, and related mouse phenotype immune system.

Disease Ontology:10 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

Wikipedia:65 Churg?Strauss syndrome (CSS, also known as eosinophilic granulomatosis with polyangiitis [EGPA] or... more...

Aliases & Classifications for Churg-Strauss Syndrome

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Churg-Strauss Syndrome, Aliases & Descriptions:

Name: Churg-Strauss Syndrome 10 12 45 62
Eosinophilic Granulomatous Vasculitis 43 62
Allergic Granulomatosis Angiitis 10 62
Granulomatous Allergic Angiitis 43 62
Churg-Strauss Vasculitis 10 43
Allergic Granulomatosis 43 62
Allergic Angiitis and Granulomatosis 43
 
Allergic Granulomatous and Angiitis 43
Angiitis, Allergic Granulomatous 62
Allergic Granulomatous Angiitis 10
Vasculitis, Churg-Strauss 62
Churg Strauss Syndrome 43
Coffin-Siris Syndrome 62
Css 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases, Cardiovascular diseases


External Ids:

Disease Ontology10 DOID:3049
SNOMED-CT57 82275008, 195362002
NCIt40 C34481
ICD9CM29 446.4

Related Diseases for Churg-Strauss Syndrome

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Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.4RNASE3, IL5
2vasculitis31.3CYSLTR1, THBD, LTF, MPO
3polyarteritis nodosa31.2MPO, LTF
4eosinophilic pneumonia31.0RNASE3, IL5
5pneumonia31.0IL5, MPO
6chronic eosinophilic pneumonia30.9RNASE3, IL5
7eosinophilia30.9CCL26, IL5, RNASE3, MPO, CYSLTR1
8hypereosinophilic syndrome30.8RNASE3, IL5
9bullous pemphigoid30.4IL5, RNASE3
10esophagitis30.4CCL26, IL5
11otitis media30.4RNASE3, LTF
12rheumatoid arthritis30.3RNASE3, LTF, MPO
13neuropathy10.9
14microscopic polyangiitis10.9
15eosinophilic granulomatosis with polyangiitis10.9
16granulomatous angiitis10.8
17glomerulonephritis10.8
18peripheral neuropathy10.7
19retinitis10.7
20myocarditis10.7
21mononeuritis10.7
22retinal artery occlusion10.7
23wells syndrome10.7
24cerebritis10.6
25central retinal artery occlusion10.6
26cholecystitis10.6
27polyneuropathy10.6
28hepatitis10.6
29mononeuritis multiplex10.6
30endomyocardial fibrosis10.6
31crescentic glomerulonephritis10.6
32myocardial infarction10.5
33temporal arteritis10.5
34aneurysm10.5
35endotheliitis10.5
36wegener granulomatosis10.5
37acalculous cholecystitis10.5
38rapidly progressive glomerulonephritis10.5
39dacryoadenitis10.5
40myositis10.5
41purpura10.5
42allergic angiitis10.5
43blindness10.5
44aspergillosis10.4
45arthritis10.4
46dilated cardiomyopathy10.4
47focal segmental glomerulosclerosis10.4
48hemolytic anemia10.4
49hepatitis c10.4
50iga glomerulonephritis10.4

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to churg-strauss syndrome

Symptoms for Churg-Strauss Syndrome

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Symptoms:

 10
  • asthma

Drugs & Therapeutics for Churg-Strauss Syndrome

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Drug clinical trials:

Search ClinicalTrials for Churg-Strauss Syndrome

Search NIH Clinical Center for Churg-Strauss Syndrome

Genetic Tests for Churg-Strauss Syndrome

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Anatomical Context for Churg-Strauss Syndrome

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MalaCards organs/tissues related to Churg-Strauss Syndrome:

33
Lung, Heart, Skin, T cells, Colon, Liver, Endothelial, Small intestine, Neutrophil, Bone, Brain, Spinal cord, Kidney, Breast, Prostate, Retina, Salivary gland, Testes

Animal Models for Churg-Strauss Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Churg-Strauss Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6LTF, IL5, MPO, CYSLTR1, THBD

Publications for Churg-Strauss Syndrome

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Articles related to Churg-Strauss Syndrome:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
An atypical caseof Churg-Strauss syndrome. (25686653)
2015
2
Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature. (25070496)
2014
3
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. (24158754)
2014
4
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
5
Heart transplantation in patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). (24709271)
2014
6
Coronary spasms, cardiomyopathy, and Churg-Strauss syndrome : A case report. (24065048)
2013
7
Clinical and laboratory characteristics of 19 patients with Churg-Strauss syndrome from a single South Australian centre. (23611179)
2013
8
Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome. (22640649)
2012
9
Double-balloon endoscopy-diagnosed multiple small intestinal ulcers in a Churg-Strauss syndrome patient. (22624072)
2012
10
Churg-Strauss syndrome with endobronchial eosinophilic vasculitis. (23154742)
2012
11
Churg Strauss syndrome associated with montelukast--case report. (22783603)
2012
12
Cutaneous Churg-Strauss syndrome: response to dapsone therapy. (21679841)
2011
13
Cardiac magnetic resonance imaging showing complete resolution of subendocardial involvement in Churg-Strauss syndrome. (20634759)
2011
14
Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors. (21468361)
2011
15
Hepatic venous outflow obstruction complicating Churg-Strauss syndrome in a 5-year-old child. (21240017)
2011
16
Showered cortical infarctions and brain atrophy in Churg-Strauss syndrome. (21282959)
2011
17
Churg-strauss syndrome. (22345778)
2011
18
Spontaneous anterior interosseous nerve palsy with Churg-Strauss syndrome. (20458608)
2010
19
Kampo medicines improved blood test and QOL in two vasculitis cases of Churg-Strauss syndrome and Henoch-ShAPnlein purpura after inadequate treatment with conventional therapies. (20463826)
2010
20
Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview. (19833618)
2010
21
Pulmonary findings in Churg-Strauss syndrome in chest X-rays and high resolution computed tomography at the time of initial diagnosis. (20623310)
2010
22
A patient with Churg-Strauss syndrome who underwent endoscopic sinus surgery under general anesthesia -A case report-. (20651999)
2010
23
A laryngeal presentation of Churg-Strauss syndrome in childhood. (19318743)
2009
24
A case of Churg-Strauss syndrome with refractory otitis media. (18384991)
2009
25
Churg-Strauss Syndrome in childhood: a clinical review. (19893067)
2009
26
Churg-Strauss syndrome presenting as acute abdomen: are gastrointestinal manifestations an indicator of poor prognosis? (20374336)
2009
27
Churg-Strauss syndrome associated with omalizumab. (18549941)
2008
28
Hypoxemia with high alveolar-arterial oxygen gradient but no lung involvement in a patient with Churg-Strauss syndrome: case report. (18336755)
2008
29
Granulomatous arteritis in cutaneous lesions of Churg-Strauss syndrome. (17381804)
2007
30
Acute coronary syndrome associated with Churg-Strauss syndrome. (18078031)
2007
31
A case of Churg-Strauss syndrome associated with antiphospholipid antibodies. (17175066)
2007
32
Remarkable effect of anticoagulation therapy in Churg-Strauss syndrome-associated neuropathy: a case report. (16834686)
2006
33
Churg-Strauss syndrome. (16612766)
2006
34
Incidence of Churg-Strauss syndrome in asthma drug users: a population-based perspective. (15940771)
2005
35
Elevated troponins and the Churg-Strauss syndrome: a case report. (15965564)
2005
36
Hepatomegaly as a rare presentation of Churg-Strauss syndrome. (16105912)
2005
37
Churg Strauss syndrome--successful induction of remission with methotrexate and unexpected high cardiac and pulmonary relapse ratio during maintenance treatment. (15675136)
2004
38
Usefulness of 18FDG/13N-ammonia PET imaging for evaluation of the cardiac damage in Churg-Strauss syndrome. (15150672)
2004
39
Churg-Strauss syndrome associated with the leukotriene antagonist montelukast. (15060812)
2004
40
Cardiac involvement of Churg Strauss syndrome demonstrated by magnetic resonance imaging. (15675140)
2004
41
Churg-strauss syndrome with cholecystitis and renal involvement. (14518684)
2003
42
The Churg Strauss syndrome (allergic granulomatous angiitis): review and update. (14625818)
2003
43
Acute cholecystitis and duodenitis associated with Churg-Strauss syndrome. (12845966)
2003
44
Effects of a nitro compound patch on neuropathy in Churg-Strauss syndrome. (12823139)
2003
45
Churg-Strauss syndrome and eosinophilic prostatitis. (19125482)
2003
46
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis. (12418444)
2002
47
Treatment of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: where do we stand? (11263763)
2001
48
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
49
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
50
Eosinophil cationic protein in a 39-year-old patient with Churg-Strauss syndrome]. (9465849)
1998

Variations for Churg-Strauss Syndrome

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Expression for genes affiliated with Churg-Strauss Syndrome

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Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for genes affiliated with Churg-Strauss Syndrome

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Pathways related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL5, THBD
29.4IL5, CCL26

Compounds for genes affiliated with Churg-Strauss Syndrome

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Compounds related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1mometasone furoate45 6110.9RNASE3, IL5
2unicap459.9RNASE3, IL5
3levocabastine45 30 1311.8RNASE3, IL5
4toluene diisocyanate459.8RNASE3, IL5
5sodium cromoglycate459.8IL5, RNASE3
611-dehydrothromboxane b2459.6THBD, RNASE3
7beclomethasone dipropionate459.6CYSLTR1, IL5, RNASE3
8lte4459.6RNASE3, IL5, CYSLTR1
9pranlukast45 30 1311.6CYSLTR1, RNASE3, IL5
10ltd4459.6RNASE3, CYSLTR1, IL5
11montelukast45 51 30 1312.6CYSLTR1, RNASE3, IL5
12ltc4459.6CYSLTR1, RNASE3, IL5
13salbutamol45 51 30 26 1313.6CYSLTR1, IL5, RNASE3
145-oxoete459.5IL5, CYSLTR1
15pgd2459.5RNASE3, CYSLTR1, IL5
16bivalirudin45 1310.5MPO, THBD
17fluticasone propionate45 51 61 1312.3RNASE3, MPO, IL5
18naphthol as-d chloroacetate459.3MPO, LTF
19hypothiocyanite45 2610.3MPO, LTF
20percoll459.2IL5, LTF, RNASE3
21theophylline45 30 26 1312.2RNASE3, CYSLTR1, THBD, IL5
22anti-fungal459.1LTF, RNASE3, IL5
23capsaicin45 3010.1RNASE3, LTF, IL5
24zymosan459.1LTF, RNASE3, MPO
25cytochalasin b459.0LTF, RNASE3, MPO
26carbohydrates459.0THBD, RNASE3, LTF
27hyaluronic acid45 269.9THBD, RNASE3, LTF
28prednisolone45 30 1310.9IL5, RNASE3, MPO, THBD
29pentoxifylline45 139.9LTF, THBD, MPO
30fluorescein45 139.9LTF, CCL26, MPO
31dextran sulfate458.9IL5, MPO, LTF
32erythromycin45 3 51 1311.9LTF, IL5, MPO
33cyclosporin a45 30 6110.6THBD, IL5, LTF, RNASE3
34budesonide45 51 1310.6IL5, RNASE3, MPO, LTF
35methacholine45 51 1310.6MPO, RNASE3, IL5, LTF
36fmlp458.5IL5, RNASE3, MPO, LTF
37endotoxin458.5THBD, LTF, RNASE3
38cyclophosphamide45 51 1310.5MPO, THBD, LTF
39indomethacin45 30 61 1311.5CYSLTR1, MPO, IL5, LTF
40creatinine458.5RNASE3, THBD, MPO, LTF
41paraffin458.4THBD, MPO, LTF, IL5
42dexamethasone45 51 30 1311.3LTF, RNASE3, IL5, CYSLTR1, THBD
43leukotriene b445 61 2610.2MPO, LTF, IL5, RNASE3, CYSLTR1
44pge2458.2CYSLTR1, MPO, IL5, LTF, RNASE3
45n-formylmethionyl-leucylphenylalanine458.1IL5, RNASE3, LTF, MPO, THBD
46heparin45 30 26 1311.1IL5, MPO, THBD, LTF, RNASE3
47h2o2458.1MPO, LTF, IL5, RNASE3, THBD
48vegf458.1IL5, MPO, LTF, THBD, RNASE3
49retinoic acid45 269.0RNASE3, IL5, THBD, LTF, MPO
50histamine45 30 269.7THBD, CYSLTR1, RNASE3, IL5, LTF, MPO

GO Terms for genes affiliated with Churg-Strauss Syndrome

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Cellular components related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.0LTF, MPO
2extracellular spaceGO:00056157.2LTF, IL5, CCL26, MPO, THBD

Biological processes related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:00324969.4MPO, THBD
2defense responseGO:00069529.3MPO, CYSLTR1
3chemotaxisGO:00069359.2CCL26, CYSLTR1
4inflammatory responseGO:00069549.0IL5, CCL26, CYSLTR1

Products for genes affiliated with Churg-Strauss Syndrome

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Sources for Churg-Strauss Syndrome

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet