CSS
MCID: CHR001
MIFTS: 56

Churg-Strauss Syndrome (CSS) malady

Immune, Cardiovascular categories

Summaries for Churg-Strauss Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Churg strauss syndrome is a rare autoimmune condition characterized by asthma, high levels of eosinophils (a type of white blood cell that helps fight infection) in the blood and tissues, and inflammation of small to medium sized blood vessels (vasculitis). the inflamed vessels can affect various organ systems including the lungs, gastrointestinal tract, skin, heart and nervous system. the cause of churg strauss syndrome is unknown. while there is no cure, the condition can be successfully managed with early diagnosis and treatment. last updated: 4/4/2011

MalaCards: Churg-Strauss Syndrome, also known as churg-strauss vasculitis, is related to asthma and wegener's granulomatosis, and has symptoms including asthma An important gene associated with Churg-Strauss Syndrome is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Selected targets of GCR-alpha and Allograft rejection. The compounds rantes and lte4 have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and spinal cord, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

Wikipedia:64 Churg–Strauss syndrome (also known as eosinophilic granulomatosis with polyangiitis [EGPA] or allergic... more...

Aliases & Classifications for Churg-Strauss Syndrome

Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek, 43NIH Rare Diseases, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Cardiovascular


Aliases & Descriptions:

churg-strauss syndrome 8 10 45 61
churg-strauss vasculitis 8 43
allergic angiitis and granulomatosis 43
allergic granulomatous and angiitis 43
allergic granulomatosis angiitis 8
allergic granulomatous angiitis 8
allergic granulomatosis 43
churg strauss syndrome 43
coffin-siris syndrome 61
css 43


External Ids:

Disease Ontology8 DOID:3049
SNOMED-CT57 195362002, 82275008
NCIt40 C34481

Related Diseases for Churg-Strauss Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.3CYSLTR1, RNASE3
2wegener's granulomatosis31.3PRTN3, MPO
3vasculitis31.3SULT1A3, THBD, CYSLTR1, LTF, PRTN3, MPO
4polyarteritis nodosa31.2MPO, PRTN3, LTF
5mononeuritis multiplex30.8PRTN3, MPO
6chronic eosinophilic pneumonia30.8RNASE3, CCL11, IL5
7hypereosinophilic syndrome30.8CCL11, RNASE3, IGHE, IL5
8hepatitis c30.6PRTN3
9rapidly progressive glomerulonephritis30.6PRTN3, MPO
10antiphospholipid syndrome30.5SULT1A3, THBD
11arthritis30.5MPO, LTF, SULT1A3, PRTN3
12allergic bronchopulmonary aspergillosis30.5IGHE, IL5
13allergic asthma30.5IL5, CCL26, CCL17, IGHE, RNASE3, CCL11
14crohn's disease30.3LTF
15uveitis30.3CCL11
16urticaria30.3RNASE3, IGHE
17acute myocardial infarction30.3THBD, SULT1A3
18nephritis30.3PRTN3, MPO, SULT1A3
19thromboembolism30.3SULT1A3, THBD
20eosinophilic gastroenteritis30.3IL5, CCL11, IGHE
21bullous pemphigoid30.3CCL11, CCL17, RNASE3, IL5, IGHE
22septic shock30.3THBD, LTF, AVP
23coffin-siris syndrome11.2
24n syndrome11.2
25micro syndrome10.9
26microscopic polyangiitis10.9
27allergic angiitis10.9
28granulomatous angiitis10.8
29central retinal artery occlusion10.7
30wells syndrome10.6
31mass syndrome10.6
32endomyocardial fibrosis10.6
33crescentic glomerulonephritis10.5
34temporal arteritis10.5
35acalculous cholecystitis10.4
36young syndrome10.4
37hemorrhage, intracerebral10.4
38retinal vasculitis10.4
39smarcb1-related coffin-siris syndrome10.4
40smarca4-related coffin-siris syndrome10.4
41smarce1-related coffin-siris syndrome10.4
42arid1a-related coffin-siris syndrome10.4
43arid1b-related coffin-siris syndrome10.4
44stroke, ischemic10.4
45branch retinal artery occlusion10.4
46focal segmental glomerulosclerosis10.4
47cryoglobulinemia10.4
48coronary aneurysm10.4
49good syndrome10.4
50exophthalmos10.4

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to churg-strauss syndrome

Clinical Features for Churg-Strauss Syndrome

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • asthma

Drugs & Therapeutics for Churg-Strauss Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Churg-Strauss Syndrome

Drug clinical trials:

Search ClinicalTrials for Churg-Strauss Syndrome

Search NIH Clinical Center for Churg-Strauss Syndrome

Search CenterWatch for Churg-Strauss Syndrome

Genetic Tests for Churg-Strauss Syndrome

Anatomical Context for Churg-Strauss Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Churg-Strauss Syndrome:

33
Brain, Retina, Spinal cord, Heart, Small intestine, Colon, Kidney, Liver, Lung, Salivary gland, Breast, Skin, Prostate, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Churg-Strauss Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Churg-Strauss Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.4CCL11, DDR1, MPO, IGHE, LTF, IL25
2MP:00053878.8THBD, KLRK1, CCL11, CCL17, DDR1, MPO

Publications for Churg-Strauss Syndrome

Sources:
51PubMed
See all sources

Articles related to Churg-Strauss Syndrome:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
2
Coronary spasms, cardiomyopathy, and Churg-Strauss syndrome : A case report. (24065048)
2013
3
Churg-Strauss Syndrome in Childhood: A Case Report. (24170259)
2013
4
Churg-Strauss syndrome mimicking myocardial infarction with cerebral vascular involvement. (23996128)
2013
5
Eosinophilic myocarditis due to Churg-Strauss syndrome with markedly elevated eosinophil cationic protein. (23428926)
2013
6
Churg-Strauss Syndrome: An Uncommon Cause of Intracerebral Hemorrhage. (24126465)
2013
7
Wells syndrome and its relationship to Churg-Strauss syndrome. (23786445)
2013
8
Churg-Strauss syndrome cardiac involvement evaluated by cardiac magnetic resonance imaging and positron-emission tomography: a prospective study on 20 patients. (22772324)
2013
9
Antineutrophil cytoplasmic autoantibodies and myeloperoxidase autoantibodies in clinical expression of Churg-Strauss syndrome. (22920496)
2013
10
Spinal hematoma complicating a Churg-Strauss syndrome patient: a previously unreported association. (22892936)
2012
11
Hypereosinophilic syndrome, Churg-Strauss syndrome and parasitic diseases: possible links between eosinophilia and thrombosis. (22272911)
2012
12
Cardiac denervation procedure to treat refractory angina in a patient with Churg-Strauss syndrome and non-obstructive coronary lesions. (22493151)
2012
13
Conjunctival granulomatosis in churg-strauss syndrome. (22965612)
2012
14
Churg-Strauss syndrome complicated by chronic periaortitis: a case report and review of the literature. (22214634)
2012
15
Serum biomarkers are similar in Churg-Strauss syndrome and hypereosinophilic syndrome. (22775568)
2012
16
Dacryoadenitis and diffuse orbital inflammation: unusual first presentations of Churg-Strauss syndrome. (21574807)
2011
17
The proportion of regulatory T cells in the peripheral blood reflects the relapse or remission status of patients with Churg-Strauss syndrome. (21646795)
2011
18
Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview. (19833618)
2010
19
Pulmonary findings in Churg-Strauss syndrome in chest X-rays and high resolution computed tomography at the time of initial diagnosis. (20623310)
2010
20
Churg Strauss syndrome: a review. (20642075)
2010
21
Churg-Strauss syndrome: a case report. (21147630)
2010
22
Churg-strauss syndrome and active chronic hepatitis B virus infection: coincidence or association? (20360926)
2010
23
Development of Churg-Strauss syndrome with severe multiple mononeuropathy after leukotriene receptor antagonist treatment in one of the monozygotic twins with asthma: case report. (19920803)
2009
24
Severe bronchospasm associated with rituximab for refractory Churg-Strauss syndrome. (19286908)
2009
25
Retraction. Increased serum vascular endothelial growth factor level in Churg-Strauss syndrome. (18938645)
2008
26
Notice of retraction: Increased expression of TRAIL receptor 3 on eosinophils in Churg-Strauss syndrome (Arthritis Rheum 2007;56:662-73). (18759266)
2008
27
Disseminated subcutaneous nodules alone as manifestations of Churg-Strauss syndrome. (18412881)
2008
28
Functionally relevant variations of the interleukin-10 gene associated with antineutrophil cytoplasmic antibody-negative Churg-Strauss syndrome, but not with Wegener's granulomatosis. (18512809)
2008
29
Acute coronary syndrome associated with Churg-Strauss syndrome. (18078031)
2007
30
Central retinal artery occlusion in an ANCA negative Churg-Strauss syndrome patient. (17522782)
2007
31
HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome. (17763415)
2007
32
Solar urticaria as a manifestation of Churg-Strauss syndrome. (17034420)
2007
33
Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients. (17471546)
2007
34
Pulmonary involvement in Churg-Strauss syndrome: an analysis of CT, clinical, and pathologic findings. (17605012)
2007
35
Churg-Strauss syndrome and Wells syndrome: coincidence or pathogenetic association? A new case report. (17428365)
2007
36
Churg-Strauss syndrome presenting with salivary gland enlargement and respiratory distress. (16463394)
2006
37
Combined central retinal artery and vein occlusion in Churg-Strauss syndrome: case report. (16965506)
2006
38
Asthma and Churg-Strauss syndrome. (17268737)
2006
39
Subendocardial and papillary muscle involvement in a patient with Churg-Strauss syndrome, detected by contrast enhanced cardiovascular magnetic resonance. (15604316)
2005
40
Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome. (16263885)
2005
41
Assessment of myocardial perfusion and fatty acid metabolism in a patient with Churg-Strauss syndrome associated with eosinophilic heart disease. (15170099)
2004
42
Image of the month. Churg-Strauss syndrome. (14988815)
2004
43
Bullous eosinophilic cellulitis (Wells' syndrome) associated with Churg-Strauss syndrome. (12602982)
2003
44
Churg-Strauss syndrome: the use of cyclophosphamide in mononeuritis. (12595649)
2003
45
Churg-Strauss syndrome: update on recent developments. (11790990)
2002
46
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
47
Clinical study on five myeloperoxidase specific anti-neutrophil cytoplasmic antibody (MPO-ANCA) positive Churg-Strauss syndrome cases]. (9852746)
1998
48
Therapy of resistant systemic necrotizing vasculitis. Polyarteritis, Churg-Strauss syndrome, Wegener's granulomatosis, and hypersensitivity vasculitis group disorders. (7732173)
1995
49
Chronic eosinophilic pneumonia (CEP) as a presenting feature of Churg-Strauss syndrome (CSS). (7875290)
1994
50
Peripheral neuropathy associated with allergic granulomatous angiitis (Churg-Strauss syndrome): clinical features and histological findings. (2852178)
1988

Genetic Variations for Churg-Strauss Syndrome

Expression for genes affiliated with Churg-Strauss Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Churg-Strauss Syndrome

Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for genes affiliated with Churg-Strauss Syndrome

Sources:
12EMD Millipore, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database
See all sources

Pathways related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL5, CCL11, THBD
2
Hide members
10.0RNASE3, HLA-DRB4, IL5, CCL11
3
Hide members
9.9IL5, CCL11, CCL26, CCL17, TNFRSF10C
49.9CCL11, CCL17, IGHE, IL5, CCL26
5
Hide members
9.8IL5, TNFRSF10C, KLRK1, CCL11, IGHE
6
Hide members
9.8IL5, CCL11, TNFRSF10C, CCL17, CCL26, DDR1
7
Hide members
9.8DDR1, IL5, CCL11, CCL26, CCL17, TNFRSF10C
8
Hide members
9.8CCL17, TNFRSF10C, DDR1, CCL11, IL5, CCL26
9
Hide members
9.6CCL17, TNFRSF10C, DDR1, IL25, CCL11, CCL26

Compounds for genes affiliated with Churg-Strauss Syndrome

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1rantes4510.5CHIA, CCL11, RNASE3
2lte44510.5RNASE3, CYSLTR1, CCL11, IL5
3beclomethasone dipropionate4510.5CYSLTR1, IGHE, RNASE3, IL5
4pranlukast45 29 1112.5IL5, RNASE3, CYSLTR1, CCL11
55-oxoete4510.5IL5, CCL11, CYSLTR1
6heparin45 29 11 2413.5LTF, CCL11, MPO, RNASE3
7unicap4510.5IGHE, RNASE3, IL5, CCL11
8pge24510.5CCL11, CYSLTR1
9toluene diisocyanate4510.5IL5, RNASE3, IGHE
10anti-histamine4510.5CCL11, RNASE3, IGHE
11ltc44510.4CCL11, RNASE3, CYSLTR1, IL5
12sodium cromoglycate4510.4CCL11, IGHE, IL5, RNASE3
13nedocromil sodium4510.4IGHE, RNASE3, IL5
14percoll4510.4PRTN3, LTF, RNASE3, IL5
15roxithromycin45 29 1112.4IL5, CCL11, CCL17
16cetirizine45 29 11 2413.4IL5, CCL11, IGHE, RNASE3
17ketotifen45 1111.4CCL11, IGHE, RNASE3, IL5
18cytochalasin b4510.4MPO, RNASE3, LTF, PRTN3
19montelukast45 50 29 1113.4CCL11, IL5, RNASE3, CYSLTR1, IGHE
20salbutamol45 50 29 11 2414.4CCL11, CYSLTR1, RNASE3, IL5, IGHE
21theophylline45 29 11 2413.4THBD, CYSLTR1, RNASE3, IL5
22fluticasone propionate45 50 60 1113.4MPO, RNASE3, CCL11, IGHE, IL5
23pgd24510.3IL5, CYSLTR1, IGHE, CCL11, RNASE3
24praziquantel45 1111.3IL5, IGHE, RNASE3
25salmeterol45 50 29 1113.3RNASE3, IL5, CCL11
26capsaicin45 2911.3RNASE3, LTF, IL5, IGHE
27leukotriene b445 60 2412.3RNASE3, CYSLTR1, LTF, MPO, CCL11, IL5
28allergens4510.3IL5, CCL11, CCL17, RNASE3, IGHE
29tarc4510.3IL5, IGHE, CCL17, CCL26, CCL11
30budesonide45 50 1112.3MPO, IGHE, LTF, RNASE3, CCL11, IL5
31methacholine45 1111.3LTF, IGHE, MPO, CCL11, IL5, RNASE3
32hyaluronic acid45 2411.3THBD, CCL11, RNASE3, LTF, PRTN3
33prednisolone45 29 1112.2MPO, THBD, IL5, RNASE3, CCL11, IGHE
34fmlp4510.2MPO, LTF, IL5, CCL11, RNASE3, PRTN3
35n-formylmethionyl-leucylphenylalanine4510.2MPO, IL5, RNASE3, THBD, LTF, PRTN3
36aspirin45 50 29 2413.2SULT1A3, THBD, CYSLTR1, CCL11, RNASE3
37indomethacin45 60 29 1113.2MPO, IGHE, IL5, CYSLTR1, CCL11, LTF
38dmso4510.2PRTN3, THBD, LAMP1, MPO, IL5
39clarithromycin45 1111.2IL5, LTF, CCL11
40azelastine45 1111.1RNASE3, IGHE, IL5
41ltd44510.1CYSLTR1, RNASE3, IL5
42cyclosporin a45 29 6012.1LTF, CCL11, CCL17, IGHE, IL5, THBD
43histamine45 29 2412.1MPO, THBD, CCL11, IGHE, RNASE3, CYSLTR1
44creatinine4510.1MPO, IGHE, LTF, RNASE3, AVP, THBD
45retinoic acid45 2410.9PRTN3, MPO, IGHE, CCL11, KLRK1, RNASE3
46dexamethasone45 50 29 1112.9LTF, CYSLTR1, THBD, CCL11, CCL17, AVP
47vegf459.8LTF, MPO, IGHE, CCL11, RNASE3, IL5
48arginine459.8THBD, AVP, SULT1A3, IL5, RNASE3, KLRK1
49calcium45 50 11 2412.5CCL11, PRTN3, CYSLTR1, MPO, CCL17, DDR1
50nitric oxide45 11 2411.5THBD, CCL11, CCL17, MPO, RNASE3, AVP

GO Terms for genes affiliated with Churg-Strauss Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.9LTF, AVP, MPO
2integral to plasma membraneGO:0058879.7CYSLTR1, DDR1, HLA-DRB4, TNFRSF10C, LAMP1, THBD
3extracellular spaceGO:0056159.6MPO, CCL11, CCL26, CCL17, CHIA, IL25
4extracellular regionGO:0055769.5AVP, CCL11, CCL17, DDR1, IGHE, LTF

Biological processes related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory response to antigenic stimulusGO:00243710.2HLA-DRB4, IL25
2chemotaxisGO:00693510.1CCL26, CCL17, CYSLTR1, CCL11
3response to fungusGO:00962010.1CHIA, IL25
4inflammatory responseGO:00695410.0CCL11, CCL26, CCL17, CYSLTR1, IL5
5branching involved in mammary gland duct morphogenesisGO:0604449.9DDR1, CCL11
6immune responseGO:0069559.8IL5, CHIA, HLA-DRB4, CCL17, CCL26, IGHE

Molecular functions related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.1CCL17, CCL26, CCL11

Products for genes affiliated with Churg-Strauss Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Churg-Strauss Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet