Churg-strauss Syndrome malady

NIH Rare Diseases: Churg Strauss syndrome is a rare autoimmune condition characterized by asthma, high levels of eosinophils (a type of white blood cell that helps fight infection) in the blood and tissues, and inflammation of small to medium sized blood vessels (vasculitis). The inflamed vessels can affect various organ systems including the lungs, gastrointestinal tract, skin, heart and nervous system. The cause of Churg Strauss syndrome is unknown. While there is no cure, the condition can be successfully managed with early diagnosis and treatment.³⁰

MalaCards: Churg-strauss Syndrome, also known as churg-strauss vasculitis, is related to asthma and chronic eosinophilic pneumonia, and has symptoms including asthma An important gene associated with Churg-strauss Syndrome is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Antigen processing and presentation and RAR-Gamma-RXR-Alpha Degradation. The compounds cyclophosphamide and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung, and related mouse phenotypes are respiratory system and hematopoietic system.

Disease Ontology: A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.⁶

Wikipedia: Churg–Strauss syndrome (also known as \"Allergic granulomatosis\") is a medium and small vessel...⁴⁴ more...

Aliases & Descriptions:

churg-strauss syndrome 6 8 32 43 churg-strauss vasculitis 6 30 allergic granulomatosis angiitis (disorder) 6 eosinophilic granulomatous vasculitis 30 allergic angiitis and granulomatosis 30 allergic granulomatous and angiitis 30

allergic granulomatous angiitis 6 granulomatous allergic angiitis 30 allergic granulomatosis 30 churg strauss syndrome 30 css 30

Diseases related to churg-strauss syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 607)

id	Related Disease	Score	Top Affiliating Genes
1	asthma	33.8	ALOX5, CYSLTR1, RNASE3
2	chronic eosinophilic pneumonia	31.7	IL5, CCL11, RNASE3
3	mononeuropathy	31.6	MPO, IGHE, PRTN3
4	polyarteritis nodosa	31.1	MPO, IFNA1, CRP, LTF, PRTN3
5	eosinophilic pneumonia	31.1	IL13, IL5, CCL11, IGHE, RNASE3
6	hepatitis	30.1	FAS, IFNA1, HLA-A, HLA-DRB1, LTF
7	wegener's granulomatosis	30.0	MPO, IL10, IL2RA, IFNG, ALOX5, SULT1A3
8	peripheral neuropathy	29.9	CHKA, AVP, MPO, IL10, IFNA1, IFNG
9	cryoglobulinemia	27.9	IL10, IL4, FAS, IFNA1, IFNG, HLA-DRB1
10	autoimmune hemolytic anemia	27.1	MPO, IL10, IL2, IL2RA, IL4, IL5
11	hepatitis c	26.6	IL10, IL2, IL4, FAS, IFNA1, IFNG
12	hemolytic anemia	26.4	MPO, IL10, IL2, IL2RA, IL4, IL5
13	neuropathy	25.9	CHKA, AVP, MPO, IL10, IL2, IL2RA
14	eosinophilia	25.2	CHIA, MPO, IL10, IL13, IL2, IL25
15	vasculitis	24.1	MPO, IL10, IL2, IL2RA, IL4, IL5
16	anemia	23.4	MPO, IL10, IL13, IL2, IL2RA, IL4
17	pneumonia	22.1	CHKA, AVP, MPO, IL10, IL13, IL2
18	arthritis	20.8	MPO, IL10, IL13, IL2, IL2RA, IL4
19	rapidly progressive glomerulonephritis	13.7	MPO, PRTN3
20	collagenous colitis	13.6	MPO, RNASE3, LTF
21	hypersensitivity vasculitis	13.6	MPO, PRTN3
22	status asthmaticus	13.6	IL5, CCL11, RNASE3
23	paragonimiasis	13.6	IL5, IGHE, RNASE3
24	giant papillary conjunctivitis	13.5	IL5, CCL11, RNASE3, LTF
25	intestinal schistosomiasis	13.5	IL13, IL5
26	mononeuritis multiplex	13.5	MPO, CRP, PRTN3
27	mononeuritis	13.5	MPO, CRP, PRTN3
28	pthirus pubis infestation	13.5	IL5, CCL11, IGHE
29	common cold	13.5	CHIA, IL5, CCL11, RNASE3
30	primary sclerosing cholangitis	13.5	MPO, HLA-A, LTF, PRTN3
31	eosinophilic gastroenteritis	13.4	IL5, CCL11, IGHE, RNASE3
32	helminthiasis	13.4	IL13, IL5, IGHE, RNASE3
33	proctitis	13.4	MPO, CRP, RNASE3, LTF
34	adult respiratory distress syndrome	13.4	MPO, HMGB1, THBD
35	halo nevi	13.4	HLA-DRB1, HLA-DRB4
36	poems syndrome	13.3	IL5, CCL11, CRP
37	newborn respiratory distress syndrome	13.3	MPO, ALOX5, HMGB1, THBD
38	diffuse panbronchiolitis	13.3	MPO, IL13, IL5, HLA-A
39	panbronchiolitis	13.3	MPO, IL13, IL5, HLA-A
40	protein-energy malnutrition	13.3	MPO, CRP, LTF
41	ascariasis	13.3	IL5, IGHE, HLA-DRB3, HLA-DRB4, RNASE3
42	obstructive lung disease	13.3	FAS, IGHE, RNASE3
43	adult t-cell leukemia	13.3	IL2RA, TRB@
44	pemphigoid gestationis	13.2	CCL11, HLA-DRB1
45	primary hyperoxaluria	13.2	AVP, MPO, CRP, THBD, PRTN3
46	rheumatoid arthritis	13.2	HLA-DRB1, CRP, PRTN3
47	crescentic glomerulonephritis	13.2	MPO, IL2RA, CRP, PRTN3
48	bullous pemphigoid	13.2	IL13, IL5, CCL11, IGHE, RNASE3
49	reactive arthritis	13.2	HLA-B, CRP, LTF, PRTN3
50	aortitis	13.1	HLA-B, CRP

Symptoms: asthma.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to churg-strauss syndrome:

²²

MGI Mouse Phenotypes related to churg-strauss syndrome:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	IL25, CYSLTR1
2	hematopoietic system phenotype	MP:0005397	9.5	DDR1, TRB@, IGHE, CCL11, IL5, IL25
3	digestive/alimentary phenotype	MP:0005381	9.0	TRB@, IFNG, IL25
4	liver/biliary system phenotype	MP:0005370	8.7	CHKA, IL2, IFNG, TRB@
5	immune system phenotype	MP:0005387	8.5	IL2, PRTN3, LTF, CYSLTR1, DDR1, TRB@
6	homeostasis/metabolism phenotype	MP:0005376	7.6	ALOX5, HMGB1, DDR1, CRP, LTF, THBD

Articles related to churg-strauss syndrome:

(show all 40)

id	Title	Authors	Year	Affiliating Genes
1	Eotaxin-3 in Churg-Strauss syndrome: a clinical and i mmunogenetic study. (21266446)	Zwerina J.... Vaglio A.	2011	CCL26
2	Distinct proteinase 3-induced cytokine patterns in We generA's granulomatosis, Churg-Strauss syndrome, and healthy controls. (21470489)	Fagin U.... Lamprecht P.	2011	PRTN3
3	Membrane proteinase 3 (mPR3) expression on neutrophil s is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS). (20412702)	Holle J.U.... Csernok E.	2010	PRTN3
4	Interleukin-25: a cytokine linking eosinophils and ad aptive immunity in Churg-Strauss syndrome. (20729468)	Terrier B.... Saadoun D.	2010	IL25
5	IL-5 pathway inhibition in the treatment of asthma an d Churg-Strauss syndrome. (20513522)	Rosenwasser L.J.... Rothenberg M.E.	2010	IL5
6	Intrinsic pathway of apoptosis in peripheral blood eo sinophils of Churg-Strauss syndrome. (19643727)	Jakiela B.... Szczeklik A.	2009	BCL2L13
7	Pathogenesis of Churg-Strauss syndrome: recent insigh ts. (19811306)	Zwerina J.... Schett G.	2009	IL4, IL13, CCL26
8	Eotaxin-3 is involved in Churg-Strauss syndrome--a serum marker closely correlating with disease activity. (18397958)	Polzer K.... Zwerina J.	2008	CCL11, CHIA, CCL26
9	Retraction of Matsuyama et al., 'Discoidin domain receptor 1 contributes to eosinophil survival in an NF-kappa B-dependent manner in Churg-Strauss syndrome', Blood 109:22-30 (Jan 2007). (18299452)		2008	DDR1
10	Focused microarray analysis of peripheral mononuclear blood cells from Churg-Strauss syndrome patients. (18263571)	Tougan T.... Nojima H.	2008	COTL1
11	Differences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma. (18586318)	Tsurikisawa N.... Akiyama K.	2008	IL10
12	Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome. (18502180)	Guida G.... Cignetti A.	2008	TRB@
13	Involvement of regulatory T cells in the pathogenesis of Churg-Strauss syndrome. (18504411)	Saito H.... Akiyama K.	2008	IL2
14	Notice of retraction: Increased expression of TRAIL receptor 3 on eosinophils in Churg-Strauss syndrome (Arthritis Rheum 2007;56:662-73). (18759266)	Mitsuyama H.... Arimura K.	2008	TNFRSF10C
15	Associations of Churg-Strauss syndrome with the HLA-DRB1 locus, and relationship to the genetics of antineutrophil cytoplasmic antibody-associated vasculitides: comment on the article by Vaglio et al. (18163478)	Wieczorek S.... Epplen J.T.	2008	HLA-DRB1
16	Functionally relevant variations of the interleukin-10 gene associated with antineutrophil cytoplasmic antibody-negative Churg-Strauss syndrome, but not with Wegener's granulomatosis. (18512809)	Wieczorek S.... Epplen J.T.	2008	IL10
17	Serum eosinophil cationic protein: a marker of disease activity in Churg-Strauss syndrome. (17804567)	Guilpain P.... Mouthon L.	2007	RNASE3
18	Increased expression of TRAIL receptor 3 on eosinophils in Churg-Strauss syndrome. (17265502)	Mitsuyama H.... Arimura K.	2007	TNFRSF10C
19	HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome. (17763415)	Vaglio A.... Neri T.M.	2007	HLA-A, HLA-DRB1, HLA-B
20	Increased serum high mobility group box-1 level in Churg-Strauss syndrome. (17437420)	Taira T.... Arimura K.	2007	IL2RA, THBD, HMGB1
21	Discoidin domain receptor 1 contributes to eosinophil survival in an NF-kappaB-dependent manner in Churg-Strauss syndrome. (16968898)	Matsuyama W.... Arimura K.	2007	DDR1
22	Initial cutaneous manifestations consistent with mononeuropathy multiplex in Churg-Strauss syndrome. (16027304)	Kawakami T.... Mizoguchi M.	2005	IGHE
23	Long term effectiveness of intravenous immunoglobulin in Churg-Strauss syndrome. (15547090)	Danieli M.G.... Danieli G.	2004	CRP
24	A case of allergic granulomatosis and angiitis (Churg-Strauss syndrome) in a 15-year-old girl (15500154)	Fujita K.... Okimoto N.	2004	CRP
25	Clinicopathological studies of peripheral neuropathy in Churg-Strauss syndrome. (12564771)	Nagashima T.... Nagashima K.	2002	CHKA, RNASE3
26	Churg-Strauss syndrome: update on recent developments. (11790990)	Gross W.L.	2002	IL5
27	The relationship of asthma therapy and Churg-Strauss syndrome: NIH workshop summary report. (11496231)	Weller P.F.... Trontell A.	2001	ALOX5
28	Hepatitis C virus infection with and without cryoglobulinemia as a case of Churg-Strauss syndrome. (10743831)	MerciAc P.... Pellegrin J.L.	2000	IFNA1
29	Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome (10614173)	Maki N.... Imai H.	1999	AVP
30	Involvement of soluble CD95 in Churg-Strauss syndrome. (10487849)	MA1schen M.... HAoussinger D.	1999	FAS
31	Inflammatory cells and cellular activation in the lower respiratory tract in Churg-Strauss syndrome. (10456969)	Schnabel A.... Gross W.L.	1999	MPO, RNASE3
32	The analysis of mRNA expression of cytokines from skin lesions in Churg-Strauss syndrome. (9575680)	Fujioka A.... Jinno S.	1998	IFNG
33	Eosinophil cationic protein in a 39-year-old patient with Churg-Strauss syndrome (9465849)	Behrens R.... Fleig W.E.	1998	RNASE3
34	Two cases of Churg-Strauss syndrome with impaired prognosis (9745302)	Nakamura Y.... Suruda T.	1998	IGHE
35	Churg-Strauss syndrome with right ventricular tumor (9589022)	Schwab J.... Gottwik M.	1998	IGHE
36	Clinical study on five myeloperoxidase specific anti-neutrophil cytoplasmic antibody (MPO-ANCA) positive Churg-Strauss syndrome cases (9852746)	Yoshihara K.... Nagasawa T.	1998	MPO
37	Churg-Strauss syndrome: serum markers of lymphocyte activation and endothelial damage. (9506572)	Schmitt W.H.... Gross W.L.	1998	THBD, SULT1A3, RNASE3
38	Autoimmune hemolytic anemia in allergic granulomatous angitis (Churg-Strauss syndrome). (8867725)	Kojima K.... Harada M.	1996	IL4, IL5, IGHE
39	A case of Churg-Strauss syndrome in which MPO-ANCA (antibodies to myeloperoxidase) appeared to reflect the disease activity (7609341)	Nakagawa A.... Takao T.	1995	MPO
40	Two cases of allergic granulomatosis and angiitis (AGA); Churg-Strauss syndrome (2084865)	Ohkubo M.... Nagao S.	1990	IGHE

Genes related to churg-strauss syndrome according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
2	PRTN3	proteinase 3	11.0	Publications
3	CYSLTR1	cysteinyl leukotriene receptor 1	11.0
4	MPO	myeloperoxidase	11.0	Publications
5	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
6	THBD	thrombomodulin	11.0	Publications
7	LTF	lactotransferrin	11.0
8	IL25	interleukin 25	11.0	Publications
9	CCL26	chemokine (C-C motif) ligand 26	11.0	Publications
10	TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	11.0	Publications
11	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	11.0	Publications
12	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
13	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	11.0	Publications
14	CHIA	chitinase, acidic	11.0	Publications
15	AVP	arginine vasopressin	11.0	Publications
16	COTL1	coactosin-like 1 (Dictyostelium)	11.0	Publications
17	DDR1	discoidin domain receptor tyrosine kinase 1	11.0	Publications
18	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
19	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
20	HMGB1	high mobility group box 1	11.0	Publications
21	CHKA	choline kinase alpha	11.0	Publications
22	TRB@	T cell receptor beta locus	11.0	Publications
23	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
24	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
25	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
26	IL13	interleukin 13	11.0	Publications
27	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
28	CRP	C-reactive protein, pentraxin-related	11.0	Publications
29	IFNA1	interferon, alpha 1	11.0	Publications
30	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
31	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
32	IL2	interleukin 2	11.0	Publications
33	IL10	interleukin 10	11.0	Publications
34	IL4	interleukin 4	11.0	Publications
35	IFNG	interferon, gamma	11.0	Publications
36	BCL2L13	BCL2-like 13 (apoptosis facilitator)	9.9	Publications

Pathways related to churg-strauss syndrome according to GeneDecks:

(show top 50)    (show all 75)

id	Pathway	Score	Top Affiliating Genes
1	Antigen processing and presentation20	10.1	HLA-DRB1, HLA-DRB3, HLA-DRB4
2	RAR-Gamma-RXR-Alpha Degradation36	10.0	CCL11, CCL26, IL2
3	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	IL2RA, IL2
4	OX40 Pathway36	9.9	IL5, IL4, IL13
5	Immune response Antigen presentation by MHC class II10	9.8	HLA-DRB3, HLA-DRB4, TRB@
6	Graft-versus-host disease20	9.5	HLA-DRB4, HLA-DRB3, HLA-B, HLA-A, IL2
7	CTL Mediated Apoptosis36	9.4	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
8	Molecular Mechanisms of Cancer36	9.3	CCL11, CCL26, IL5, IL2, IL13
9	Viral myocarditis20	9.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
10	Immune response IL-22 signaling pathway10	9.2	TRB@, HLA-DRB4, HLA-DRB3, HLA-DRB1, IL2RA, IL2
11	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.2	FAS, IL2RA, IL2, IL10
12	Immune response_IL-22 signaling pathway41	9.2	TRB@, HLA-DRB4, HLA-DRB3, HLA-DRB1, IL2RA, IL2
13	IL-6 Pathway36	9.1	CCL11, CCL26, IL5, IL4, IL10
14	Hematopoietic cell lineage20	9.1	HLA-DRB4, HLA-DRB3, HLA-DRB1, IL5, IL4, IL2RA
15	NFAT Signaling and Lymphocyte Interactions36	9.1	CCL11, CCL26, IL5, IL4, IL2, IL13
16	Regulation of eIF4 and p70S6K36	9.1	CCL11, IL5, IL4, IL2, IL13
17	Phagosome20	9.0	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A, MPO
18	PGC1Alpha Pathway36	8.9	TNFRSF10C, CCL11, CCL26, IL5, IL4, IL2
19	CDC42 Pathway36	8.9	HLA-A, HLA-B, HLA-DRB1, HLA-DRB3, HLA-DRB4, DDR1
20	ICos-ICosL Pathway in T-Helper Cell36	8.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, IL2RA, IL2
21	MIF Mediated Glucocorticoid Regulation36	8.5	CCL11, CCL26, IL5, IL4, IL2, IL13
22	MIF Regulation of Innate Immune Cells36	8.5	CCL11, CCL26, IL5, IL4, IL2, IL13
23	PEDF Induced Signaling36	8.5	CCL11, CCL26, IL5, IL4, IL2, IL13
24	SOCS Pathway36	8.5	CCL11, CCL26, IL5, IL4, IL2, IL13
25	Intestinal immune network for IgA production20	8.5	HLA-DRB4, HLA-DRB3, HLA-DRB1, IL5, IL4, IL2
26	Influenza A20	8.4	TNFRSF10C, HLA-DRB4, HLA-DRB3, HLA-DRB1, IFNG, IFNA1
27	Natural killer cell mediated cytotoxicity20	8.4	TNFRSF10C, HLA-B, HLA-A, IFNG, IFNA1, FAS
28	Asthma20	8.3	RNASE3, HLA-DRB4, HLA-DRB3, HLA-DRB1, CCL11, IL5
29	Akt Signaling36	8.3	DDR1, TNFRSF10C, CCL11, CCL26, IL4, IL2RA
30	Toxoplasmosis20	8.3	HLA-DRB4, HLA-DRB3, HLA-DRB1, ALOX5, IFNG, IL10
31	Endothelin-1 Signaling Pathway36	8.3	DDR1, CCL11, CCL26, IL5, IL4, IL2
32	all-trans-Retinoic Acid Signaling in Brain36	8.3	ALOX5, CCL11, CCL26, IL5, IL4, IL2
33	Glucocorticoid Receptor Signaling36	8.2	TNFRSF10C, CCL11, CCL26, IL5, IL4, IL2RA
34	Leishmaniasis20	8.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, IFNG, IL4, IL10
35	STAT3 Pathway36	8.2	TNFRSF10C, CCL11, CCL26, IL5, IL4, IL2RA
36	TGF-Beta Pathway36	8.1	TNFRSF10C, CCL11, CCL26, IL5, IL4, IL2RA
37	PAK Pathway36	8.1	CCL11, CCL26, IL5, IL4, IL2RA, IL2
38	MAPK Family Pathway36	8.1	CCL11, CCL26, IL5, IL4, IL2RA, IL2
39	Tec Kinases Signaling36	8.1	TNFRSF10C, CCL11, CCL26, IL5, IL4, IL2RA
40	Antioxidant Action of Vitamin-C36	8.0	TNFRSF10C, CCL11, CCL26, IL5, IL4, IL2RA
41	Type I diabetes mellitus20	8.0	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A, IFNG
42	p38 Signaling36	7.9	DDR1, TNFRSF10C, CCL11, CCL26, IL5, IL4
43	Cytokine Network36	7.7	IFNG, IFNA1, IL5, IL4, IL2, IL13
44	Measles20	7.7	TNFRSF10C, IFNG, IFNA1, FAS, IL4, IL2RA
45	THC Differentiation Pathway36	7.5	HLA-DRB4, HLA-DRB3, HLA-DRB1, IFNG, IL4, IL2RA
46	Jak-STAT signaling pathway20	7.5	IFNG, IFNA1, IL5, IL4, IL2RA, IL2
47	Autoimmune thyroid disease20	7.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A, IFNA1
48	JAK-STAT Pathway36	6.8	DDR1, TNFRSF10C, IFNG, IFNA1, CCL11, CCL26
49	Allograft rejection20	6.7	HLA-B, HLA-A, IFNG, FAS, IL5, IL4
50	Cytokine-cytokine receptor interaction20	6.6	CCL26, FAS, IL5, IL4, IL2RA, IL25

Compounds related to churg-strauss syndrome according to GeneDecks:

(show top 50)    (show all 217)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.5	TRB@, LTF
2	ionomycin32	10.5	CCL11, IL5
3	ivig32	10.5	CRP
4	budesonide32 42 9 9	13.3	IGHE, CCL11, RNASE3, LTF
5	aspartate32	10.1	THBD, ALOX5, LTF, SULT1A3
6	endotoxin32	9.9	CCL11, HMGB1, CRP, LTF, THBD
7	vegf32	9.8	MPO, ALOX5, CRP, RNASE3, LTF, THBD
8	pge232	9.8	LTF, IL13, CYSLTR1, IL5, ALOX5, CCL11
9	heparin32 9 18 9	12.8	SULT1A3, RNASE3, MPO, HMGB1, CCL11, ALOX5
10	n acetylcysteine32	9.7	IL2RA, LTF, IGHE, RNASE3, ALOX5, CCL11
11	n-formylmethionyl-leucylphenylalanine32	9.7	IL5, CCL11, PRTN3, THBD, LTF, RNASE3
12	pgd232	9.6	IL13, RNASE3, CYSLTR1, ALOX5, CCL11, IL5
13	pranlukast32 9 9	11.4	RNASE3, IL4, IL5, CCL11, ALOX5, CYSLTR1
14	salbutamol32 34 9 18 9	13.2	CYSLTR1, CCL11, IL5, IGHE, IL13, IL10
15	leukotriene b432 42 18	11.1	LTF, CCL11, ALOX5, IL13, MPO, RNASE3
16	okt332	8.9	IL10, FAS, CRP, IL2, IL2RA
17	salmeterol32 42 9 9	11.9	RNASE3, CCL11, IL5, IL4, IL2, IL13
18	praziquantel32 9 9	10.9	IL10, IL13, RNASE3, IL4, IGHE, IL5
19	methacholine32 9 9	10.8	MPO, IL13, IL4, CCL11, RNASE3, IGHE
20	theophylline32 9 18 9	11.8	IL2RA, RNASE3, IL10, CYSLTR1, IL5, IL13
21	aspirin32 34 18	10.7	CCL11, THBD, RNASE3, CRP, CYSLTR1, SULT1A3
22	fluticasone propionate32 42 9 9	11.4	IL4, RNASE3, MPO, IL13, IL5, CCL11
23	sb 20358032 42	9.3	CRP, CCL11, ALOX5, IFNG, IL13
24	montelukast32 34 9 9	11.2	CCL11, IL5, IL13, IL10, IL2RA, IL4
25	creatinine32	8.1	RNASE3, IGHE, AVP, THBD, CHKA, LTF
26	arginine32	8.1	ALOX5, HLA-A, HLA-B, HLA-DRB1, SULT1A3, RNASE3
27	azathioprine32 34 9 9	11.1	IL4, CRP, LTF, THBD, PRTN3, IL2
28	rolipram32 42	9.0	IL5, IL4, IL13, IL10, IFNG, ALOX5
29	tarc32	7.9	IFNG, CCL26, CCL11, IGHE, IL13, IL5
30	infliximab32 9 9	9.7	PRTN3, CRP, IFNG, IGHE, IL4, FAS
31	il-1232	7.7	IL2, IL4, IL10, IFNG, IFNA1, IL5
32	allergens32	7.6	IL10, IFNG, IGHE, IL13, IL4, IL5
33	pentoxifylline32 9 9	9.6	LTF, IL4, IL2RA, IL2, IL13, MPO
34	il 1032	7.6	IFNG, IL10, IL5, IL4, IL13, IL2
35	ifn-alpha32	7.5	IFNG, IFNA1, FAS, IL2RA, IL2, IL13
36	polyinosinic-polycytidylic acid32	7.4	HLA-B, IL2, IFNA1, IFNG, IL10, IL5
37	paraffin32	7.4	CHKA, MPO, THBD, LTF, HLA-B, IL10
38	glatiramer acetate32 9 9	9.3	IL10, IL13, IL2, IL4, IL5, IFNA1
39	neopterin32	7.3	CRP, IFNA1, IL2RA, IL2, IL10, LTF
40	indomethacin32 9 9	9.1	MPO, IL13, IL2, IL2RA, IL4, IL5
41	actinomycin d32	7.0	THBD, IL13, LTF, IFNG, IFNA1, IGHE
42	retinoic acid32 42 18	8.9	MPO, IL5, IL13, FAS, CCL11, IGHE
43	prednisolone32 9 9	8.7	THBD, MPO, IL10, IL13, IL2, RNASE3
44	histamine32 18	7.6	THBD, LTF, RNASE3, IL13, IL5, IL4
45	tacrolimus32 34 9 9	9.4	ALOX5, IFNG, IFNA1, CCL11, IL5, IL4
46	cycloheximide32	6.2	IL10, CRP, THBD, IL13, IL2, PRTN3
47	rantes32	6.2	HLA-B, IFNG, IFNA1, CHIA, IL10, IL13
48	tyrosine32	5.8	HLA-DRB1, HLA-B, HLA-A, IFNA1, CCL11, CHKA
49	cyclosporin a32 42	6.4	FAS, IL5, IL4, IL2RA, IL2, IL13
50	dexamethasone32 42 34 9 9	8.9	FAS, IL5, IL4, IL2RA, IL2, IL13

Cellular components related to churg-strauss syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1
2	clathrin-coated endocytic vesicle membrane	GO:030669	9.8	HLA-DRB1, HLA-DRB3, HLA-DRB4
3	transport vesicle membrane	GO:030658	9.8	HLA-DRB1, HLA-DRB3, HLA-DRB4
4	trans-Golgi network membrane	GO:032588	9.5	HLA-DRB4, HLA-DRB3, HLA-DRB1
5	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.3	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
6	ER to Golgi transport vesicle membrane	GO:012507	9.3	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
7	integral to plasma membrane	GO:005887	8.4	THBD, CYSLTR1, DDR1, TNFRSF10C, HLA-DRB4, HLA-DRB3
8	external side of plasma membrane	GO:009897	7.9	HLA-DRB4, HLA-DRB3, HLA-DRB1, IFNG, FAS, IL4
9	extracellular region	GO:005576	7.3	LTF, RNASE3, CRP, DDR1, HMGB1, IFNG
10	extracellular space	GO:005615	6.3	CHIA, THBD, CRP, HMGB1, IFNG, CCL11

Biological processes related to churg-strauss syndrome according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of interleukin-10 secretion	GO:2001179	10.1	HLA-DRB4, HLA-DRB3, HLA-DRB1
2	positive regulation of vasoconstriction	GO:045907	10.1	CYSLTR1, ALOX5, AVP
3	regulation of interleukin-4 production	GO:032673	10.1	HLA-DRB4, HLA-DRB3, HLA-DRB1
4	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.1	HLA-DRB4, HLA-DRB3, HLA-DRB1
5	humoral immune response mediated by circulating immunoglobulin	GO:002455	10.0	HLA-DRB4, HLA-DRB3, HLA-DRB1
6	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:035774	10.0	HLA-DRB4, HLA-DRB3, HLA-DRB1
7	T-helper 1 type immune response	GO:042088	10.0	HLA-DRB1, HLA-DRB3, HLA-DRB4
8	protein tetramerization	GO:051262	9.9	HLA-DRB1, HLA-DRB3, HLA-DRB4
9	inflammatory response to antigenic stimulus	GO:002437	9.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HMGB1, IL25
10	negative regulation of interferon-gamma production	GO:032689	9.5	IL10, HLA-DRB1, HLA-DRB3, HLA-DRB4
11	negative regulation of T cell proliferation	GO:042130	9.5	IL10, HLA-DRB1, HLA-DRB3, HLA-DRB4
12	regulation of isotype switching	GO:045191	9.5	IL10, IL4
13	detection of bacterium	GO:016045	9.5	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
14	positive regulation of B cell proliferation	GO:030890	9.2	IL5, IL4, IL2, IL13
15	type 2 immune response	GO:042092	9.2	IL10, IL4
16	chemotaxis	GO:006935	9.1	CYSLTR1, CCL11, CCL26, IL4
17	inflammatory response	GO:006954	9.0	CRP, CYSLTR1, CCL11, CCL26, IL5, IL13
18	cell-cell signaling	GO:007267	8.9	AVP, IL10, IL13, IL2, CCL26
19	defense response to bacterium	GO:042742	8.9	LTF, RNASE3, IFNG, IL10
20	positive regulation of isotype switching to IgG isotypes	GO:048304	8.9	IFNG, IL4, IL2
21	signal transduction	GO:007165	8.8	TNFRSF10C, HLA-DRB4, HLA-DRB3, CCL11, CCL26, FAS
22	positive regulation of MHC class II biosynthetic process	GO:045348	8.8	IL10, IL4, IFNG
23	interferon-gamma-mediated signaling pathway	GO:060333	8.6	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A, IFNG
24	cytokine-mediated signaling pathway	GO:019221	8.5	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A, IFNG
25	immune response	GO:006955	7.0	CHIA, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A

Molecular functions related to churg-strauss syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide antigen binding	GO:042605	9.8	HLA-DRB1, HLA-DRB3, HLA-DRB4
2	MHC class II receptor activity	GO:032395	9.5	HLA-DRB1, HLA-DRB3, HLA-DRB4
3	cytokine activity	GO:005125	7.2	IL10, HMGB1, IFNG, IL5, IL4, IL25