CSS
MCID: CHR001
MIFTS: 58

Churg-Strauss Syndrome (CSS) malady

Rare diseases, Cardiovascular diseases, Immune diseases categories
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Summaries for Churg-Strauss Syndrome

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NIH Rare Diseases:42 Churg strauss syndrome is a rare autoimmune condition characterized by asthma, high levels of eosinophils (a type of white blood cell that helps fight infection) in the blood and tissues, and inflammation of small to medium sized blood vessels (vasculitis). the inflamed vessels can affect various organ systems including the lungs, gastrointestinal tract, skin, heart and nervous system. the cause of churg strauss syndrome is unknown. while there is no cure, the condition can be successfully managed with early diagnosis and treatment. last updated: 4/4/2011

MalaCards based summary: Churg-Strauss Syndrome, also known as eosinophilic granulomatous vasculitis, is related to asthma and eosinophilic pneumonia, and has symptoms including An important gene associated with Churg-Strauss Syndrome is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Selected targets of GCR alpha and IL4-mediated signaling events. The compounds mometasone furoate and unicap have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and skin, and related mouse phenotype immune system.

Disease Ontology:8 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

Wikipedia:65 Churg?Strauss syndrome (CSS, also known as eosinophilic granulomatosis with polyangiitis [EGPA] or... more...

Aliases & Classifications for Churg-Strauss Syndrome

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Churg-Strauss Syndrome, Aliases & Descriptions:

Name: Churg-Strauss Syndrome 8 10 44 62
Eosinophilic Granulomatous Vasculitis 42 62
Allergic Granulomatosis Angiitis 8 62
Granulomatous Allergic Angiitis 42 62
Churg-Strauss Vasculitis 8 42
Allergic Granulomatosis 42 62
Allergic Angiitis and Granulomatosis 42
 
Allergic Granulomatous and Angiitis 42
Angiitis, Allergic Granulomatous 62
Allergic Granulomatous Angiitis 8
Vasculitis, Churg-Strauss 62
Churg Strauss Syndrome 42
Coffin-Siris Syndrome 62
Css 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:3049
NCIt39 C34481
SNOMED-CT57 82275008, 195362002
ICD9CM27 446.4

Related Diseases for Churg-Strauss Syndrome

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Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.8RNASE3, IL5
2eosinophilic pneumonia31.3RNASE3, IL5
3chronic eosinophilic pneumonia31.3IL5, RNASE3
4polyarteritis nodosa31.3MPO, LTF
5pneumonia31.2IL5, MPO
6hypereosinophilic syndrome31.1RNASE3, IL5
7vasculitis30.9LTF, MPO, CYSLTR1, THBD
8bullous pemphigoid30.7IL5, RNASE3
9esophagitis30.6CCL26, IL5
10otitis media30.5RNASE3, LTF
11eosinophilia30.4CYSLTR1, MPO, RNASE3, CCL26, IL5
12septic shock30.3LTF, THBD
13rheumatoid arthritis29.9LTF, RNASE3, MPO
14microscopic polyangiitis10.9
15neuropathy10.9
16wegener's granulomatosis10.8
17eosinophilic granulomatosis with polyangiitis10.8
18granulomatosis with polyangiitis10.8
19granulomatous angiitis10.8
20glomerulonephritis10.8
21retinitis10.8
22myocarditis10.7
23peripheral neuropathy10.7
24retinal artery occlusion10.7
25wells syndrome10.7
26central retinal artery occlusion10.7
27mononeuritis10.7
28cerebritis10.6
29cholecystitis10.6
30mononeuritis multiplex10.6
31endomyocardial fibrosis10.6
32crescentic glomerulonephritis10.6
33polyneuropathy10.6
34hepatitis10.5
35myocardial infarction10.5
36temporal arteritis10.5
37aneurysm10.5
38endotheliitis10.5
39bronchitis10.5RNASE3
40collagenous colitis10.5RNASE3
41chronic rhinitis10.5RNASE3
42conjunctivitis10.5RNASE3
43acalculous cholecystitis10.5
44rapidly progressive glomerulonephritis10.5
45dacryoadenitis10.5
46purpura10.5
47allergic angiitis10.5
48thromboembolism10.5
49paragonimiasis10.4IL5
50arthritis10.4

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to churg-strauss syndrome

Symptoms for Churg-Strauss Syndrome

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Drugs & Therapeutics for Churg-Strauss Syndrome

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Drug clinical trials:

Search ClinicalTrials for Churg-Strauss Syndrome

Search NIH Clinical Center for Churg-Strauss Syndrome

Genetic Tests for Churg-Strauss Syndrome

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Anatomical Context for Churg-Strauss Syndrome

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MalaCards organs/tissues related to Churg-Strauss Syndrome:

32
Lung, Heart, Skin, T cells, Liver, Colon, Endothelial, Small intestine, Neutrophil, Bone, Spinal cord, Kidney, Breast, Prostate, Brain, Retina, Salivary gland, Testes

Animal Models for Churg-Strauss Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Churg-Strauss Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6LTF, IL5, MPO, CYSLTR1, THBD

Publications for Churg-Strauss Syndrome

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Articles related to Churg-Strauss Syndrome:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature. (25070496)
2014
2
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. (24158754)
2014
3
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
4
Heart transplantation in patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). (24709271)
2014
5
Coronary spasms, cardiomyopathy, and Churg-Strauss syndrome : A case report. (24065048)
2013
6
Clinical and laboratory characteristics of 19 patients with Churg-Strauss syndrome from a single South Australian centre. (23611179)
2013
7
Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome. (22640649)
2012
8
Double-balloon endoscopy-diagnosed multiple small intestinal ulcers in a Churg-Strauss syndrome patient. (22624072)
2012
9
Churg-Strauss syndrome with endobronchial eosinophilic vasculitis. (23154742)
2012
10
Churg Strauss syndrome associated with montelukast--case report. (22783603)
2012
11
Churg-Strauss syndrome presenting with acute myocarditis and cardiogenic shock. (21963398)
2012
12
Churg-Strauss syndrome manifesting as cholestasis and diagnosed by liver biopsy. (22882337)
2012
13
Cutaneous Churg-Strauss syndrome: response to dapsone therapy. (21679841)
2011
14
Cardiac magnetic resonance imaging showing complete resolution of subendocardial involvement in Churg-Strauss syndrome. (20634759)
2011
15
Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors. (21468361)
2011
16
Hepatic venous outflow obstruction complicating Churg-Strauss syndrome in a 5-year-old child. (21240017)
2011
17
Showered cortical infarctions and brain atrophy in Churg-Strauss syndrome. (21282959)
2011
18
Churg-strauss syndrome. (22345778)
2011
19
Spontaneous anterior interosseous nerve palsy with Churg-Strauss syndrome. (20458608)
2010
20
Kampo medicines improved blood test and QOL in two vasculitis cases of Churg-Strauss syndrome and Henoch-ShAPnlein purpura after inadequate treatment with conventional therapies. (20463826)
2010
21
Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview. (19833618)
2010
22
Pulmonary findings in Churg-Strauss syndrome in chest X-rays and high resolution computed tomography at the time of initial diagnosis. (20623310)
2010
23
A patient with Churg-Strauss syndrome who underwent endoscopic sinus surgery under general anesthesia -A case report-. (20651999)
2010
24
A case of Churg-Strauss syndrome with refractory otitis media. (18384991)
2009
25
Churg-Strauss Syndrome in childhood: a clinical review. (19893067)
2009
26
Churg-Strauss syndrome presenting as acute abdomen: are gastrointestinal manifestations an indicator of poor prognosis? (20374336)
2009
27
Churg-Strauss syndrome associated with omalizumab. (18549941)
2008
28
Hypoxemia with high alveolar-arterial oxygen gradient but no lung involvement in a patient with Churg-Strauss syndrome: case report. (18336755)
2008
29
Granulomatous arteritis in cutaneous lesions of Churg-Strauss syndrome. (17381804)
2007
30
Acute coronary syndrome associated with Churg-Strauss syndrome. (18078031)
2007
31
Remarkable effect of anticoagulation therapy in Churg-Strauss syndrome-associated neuropathy: a case report. (16834686)
2006
32
Churg-Strauss syndrome. (16612766)
2006
33
Mesalazine-induced Churg-Strauss syndrome in a patient with Crohn's disease and sclerosing cholangitis. (16859609)
2006
34
Incidence of Churg-Strauss syndrome in asthma drug users: a population-based perspective. (15940771)
2005
35
Elevated troponins and the Churg-Strauss syndrome: a case report. (15965564)
2005
36
Hepatomegaly as a rare presentation of Churg-Strauss syndrome. (16105912)
2005
37
Churg Strauss syndrome--successful induction of remission with methotrexate and unexpected high cardiac and pulmonary relapse ratio during maintenance treatment. (15675136)
2004
38
Usefulness of 18FDG/13N-ammonia PET imaging for evaluation of the cardiac damage in Churg-Strauss syndrome. (15150672)
2004
39
Churg-Strauss syndrome associated with the leukotriene antagonist montelukast. (15060812)
2004
40
Cardiac involvement of Churg Strauss syndrome demonstrated by magnetic resonance imaging. (15675140)
2004
41
Churg-strauss syndrome with cholecystitis and renal involvement. (14518684)
2003
42
The Churg Strauss syndrome (allergic granulomatous angiitis): review and update. (14625818)
2003
43
Acute cholecystitis and duodenitis associated with Churg-Strauss syndrome. (12845966)
2003
44
Effects of a nitro compound patch on neuropathy in Churg-Strauss syndrome. (12823139)
2003
45
Churg-Strauss syndrome and eosinophilic prostatitis. (19125482)
2003
46
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis. (12418444)
2002
47
Treatment of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: where do we stand? (11263763)
2001
48
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
49
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
50
Eosinophil cationic protein in a 39-year-old patient with Churg-Strauss syndrome]. (9465849)
1998

Variations for Churg-Strauss Syndrome

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Expression for genes affiliated with Churg-Strauss Syndrome

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Expression patterns in normal tissues for genes affiliated with Churg-Strauss Syndrome

Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for genes affiliated with Churg-Strauss Syndrome

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Pathways related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL5, THBD
29.4IL5, CCL26

Compounds for genes affiliated with Churg-Strauss Syndrome

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Compounds related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1mometasone furoate44 6110.9RNASE3, IL5
2unicap449.9RNASE3, IL5
3levocabastine44 28 1111.8RNASE3, IL5
4toluene diisocyanate449.8RNASE3, IL5
5sodium cromoglycate449.8IL5, RNASE3
611-dehydrothromboxane b2449.6THBD, RNASE3
7beclomethasone dipropionate449.6CYSLTR1, IL5, RNASE3
8lte4449.6RNASE3, IL5, CYSLTR1
9pranlukast44 28 1111.6CYSLTR1, RNASE3, IL5
10ltd4449.6RNASE3, CYSLTR1, IL5
11montelukast44 50 28 1112.6CYSLTR1, RNASE3, IL5
12ltc4449.6CYSLTR1, RNASE3, IL5
13salbutamol44 50 28 24 1113.6CYSLTR1, IL5, RNASE3
145-oxoete449.5IL5, CYSLTR1
15pgd2449.5RNASE3, CYSLTR1, IL5
16bivalirudin44 1110.5MPO, THBD
17fluticasone propionate44 50 61 1112.3RNASE3, MPO, IL5
18naphthol as-d chloroacetate449.3MPO, LTF
19hypothiocyanite44 2410.3MPO, LTF
20percoll449.2IL5, LTF, RNASE3
21theophylline44 28 24 1112.2RNASE3, CYSLTR1, THBD, IL5
22anti-fungal449.1LTF, RNASE3, IL5
23capsaicin44 2810.1RNASE3, LTF, IL5
24zymosan449.1LTF, RNASE3, MPO
25cytochalasin b449.0LTF, RNASE3, MPO
26carbohydrates449.0THBD, RNASE3, LTF
27hyaluronic acid44 249.9THBD, RNASE3, LTF
28prednisolone44 28 1110.9IL5, RNASE3, MPO, THBD
29pentoxifylline44 119.9LTF, THBD, MPO
30fluorescein44 119.9LTF, CCL26, MPO
31dextran sulfate448.9IL5, MPO, LTF
32erythromycin44 2 50 1111.9LTF, IL5, MPO
33cyclosporin a44 28 6110.6THBD, IL5, LTF, RNASE3
34budesonide44 50 1110.6IL5, RNASE3, MPO, LTF
35methacholine44 50 1110.6MPO, RNASE3, IL5, LTF
36fmlp448.5IL5, RNASE3, MPO, LTF
37endotoxin448.5THBD, LTF, RNASE3
38cyclophosphamide44 50 1110.5MPO, THBD, LTF
39indomethacin44 28 61 1111.5CYSLTR1, MPO, IL5, LTF
40creatinine448.5RNASE3, THBD, MPO, LTF
41paraffin448.4THBD, MPO, LTF, IL5
42dexamethasone44 50 28 1111.3LTF, RNASE3, IL5, CYSLTR1, THBD
43leukotriene b444 61 2410.2MPO, LTF, IL5, RNASE3, CYSLTR1
44pge2448.2CYSLTR1, MPO, IL5, LTF, RNASE3
45n-formylmethionyl-leucylphenylalanine448.1IL5, RNASE3, LTF, MPO, THBD
46heparin44 28 24 1111.1IL5, MPO, THBD, LTF, RNASE3
47h2o2448.1MPO, LTF, IL5, RNASE3, THBD
48vegf448.1IL5, MPO, LTF, THBD, RNASE3
49retinoic acid44 249.0RNASE3, IL5, THBD, LTF, MPO
50histamine44 28 249.7THBD, CYSLTR1, RNASE3, IL5, LTF, MPO

GO Terms for genes affiliated with Churg-Strauss Syndrome

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Cellular components related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.0LTF, MPO
2extracellular spaceGO:0056157.2LTF, IL5, CCL26, MPO, THBD

Biological processes related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.4MPO, THBD
2defense responseGO:0069529.3MPO, CYSLTR1
3chemotaxisGO:0069359.2CCL26, CYSLTR1
4inflammatory responseGO:0069549.0IL5, CCL26, CYSLTR1

Products for genes affiliated with Churg-Strauss Syndrome

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Sources for Churg-Strauss Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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36MGI
39NCIt
40NDF-RT
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47OMIM via Orphanet
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