MCID: CHR001
MIFTS: 49

Churg-Strauss Syndrome malady

Categories: Cardiovascular diseases, Immune diseases

Aliases & Classifications for Churg-Strauss Syndrome

Aliases & Descriptions for Churg-Strauss Syndrome:

Name: Churg-Strauss Syndrome 12 52 42 14 69
Allergic Granulomatosis Angiitis 12
Allergic Granulomatous Angiitis 12
Churg-Strauss Vasculitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3049
ICD10 33 M30.1
MeSH 42 D015267
NCIt 47 C34481
SNOMED-CT 64 195362002 82275008
UMLS 69 C0008728

Summaries for Churg-Strauss Syndrome

Disease Ontology : 12 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

MalaCards based summary : Churg-Strauss Syndrome, also known as allergic granulomatosis angiitis, is related to hypersensitivity vasculitis and exophthalmos, and has symptoms including asthma An important gene associated with Churg-Strauss Syndrome is MPO (Myeloperoxidase), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Methotrexate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and t cells, and related phenotypes are hematopoietic system and immune system

Wikipedia : 71 Eosinophilic granulomatosis with polyangiitis (EGPA; also known as Churg-Strauss syndrome [CSS] or... more...

Related Diseases for Churg-Strauss Syndrome

Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
id Related Disease Score Top Affiliating Genes
1 hypersensitivity vasculitis 29.7 CD40LG IL5
2 exophthalmos 29.6 CD40LG IL10 TNF
3 uveitis 29.6 CD40LG MPO TNF
4 goodpasture syndrome 29.2 CD40LG IL10 THBD TNF
5 eosinophilic granulomatosis with polyangiitis 12.2
6 allergic angiitis 12.0
7 asthma 10.5
8 neuropathy 10.5
9 vasculitis 10.5
10 microscopic polyangiitis 10.5
11 polyarteritis nodosa 10.5
12 granulomatous angiitis 10.4
13 retinitis 10.4
14 glomerulonephritis 10.4
15 myocarditis 10.3
16 cerebritis 10.3
17 cholecystitis 10.3
18 retinal artery occlusion 10.3
19 wells syndrome 10.3
20 restrictive cardiomyopathy 10.3 IL5 RNASE3
21 marasmus 10.3 IL5 RNASE3
22 central retinal artery occlusion 10.3
23 polyneuropathy 10.3
24 hepatitis 10.3
25 lens-induced iridocyclitis 10.2 IL5 RNASE3
26 vulvar disease 10.2 MPO RNASE3
27 spastic paraplegia 3a, autosomal dominant 10.2 IL5 RNASE3
28 pneumonia 10.2
29 eosinophilic pneumonia 10.2
30 mononeuritis multiplex 10.2
31 cardiomyopathy 10.2
32 filariasis 10.2 MPO PRTN3 RNASE3
33 chronic eosinophilic pneumonia 10.2
34 endomyocardial fibrosis 10.2
35 crescentic glomerulonephritis 10.2
36 metal allergy 10.2 IL5 MPO RNASE3
37 autosomal dominant charcot-marie-tooth disease type 2 with giant axons 10.2 MPO TNF
38 small intestine lymphoma 10.2 IL5 MPO RNASE3
39 prostate calculus 10.2 PRTN3 TNF
40 mirizzi syndrome 10.2 MPO TNF
41 opiate dependence 10.1 IL5 PRTN3 THBD
42 aortic atherosclerosis 10.1 IL5 TNF
43 renal hypertension 10.1 CCL17 IL5 RNASE3
44 aneurysm 10.1
45 temporal arteritis 10.1
46 endotheliitis 10.1
47 thrombosis 10.1
48 hypereosinophilic syndrome 10.1
49 myocardial infarction 10.1
50 glucocorticoid resistance 10.1 IL5 MPO RNASE3

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to Churg-Strauss Syndrome

Symptoms & Phenotypes for Churg-Strauss Syndrome

Symptoms:

12
  • asthma

MGI Mouse Phenotypes related to Churg-Strauss Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 PRTN3 THBD TNF CCL17 CD40LG IL10
2 immune system MP:0005387 9.23 PRTN3 THBD TNF CCL17 CD40LG IL10

Drugs & Therapeutics for Churg-Strauss Syndrome

Drugs for Churg-Strauss Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 50-18-0, 6055-19-2 2907
3
Azathioprine Approved Phase 4,Phase 3,Early Phase 1 446-86-6 2265
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
6
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
7
Mycophenolic acid Approved Phase 4 24280-93-1 446541
8
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
9
rituximab Approved Phase 4,Phase 3,Phase 2,Early Phase 1 174722-31-7 10201696
10
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 54575, 6560146 143
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
12 Prednisolone acetate Phase 4,Phase 3
13 Alkylating Agents Phase 4,Phase 3,Phase 2
14 glucocorticoids Phase 4,Phase 3,Phase 2
15 Folic Acid Antagonists Phase 4,Phase 2
16 Gastrointestinal Agents Phase 4
17 Neuroprotective Agents Phase 4
18 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
19 Dermatologic Agents Phase 4,Phase 2
20 Hormone Antagonists Phase 4,Phase 3,Phase 2
21 Hormones Phase 4,Phase 3,Phase 2
22 Peripheral Nervous System Agents Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
24 Vitamin B Complex Phase 4,Phase 2
25 Prednisolone hemisuccinate Phase 4,Phase 3
26 Prednisolone phosphate Phase 4,Phase 3
27 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
28 Protective Agents Phase 4
29 Antiemetics Phase 4
30 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
31 Antimetabolites Phase 4,Phase 3,Phase 2
32 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
33 Methylprednisolone acetate Phase 4,Phase 3
34 Methylprednisolone Hemisuccinate Phase 4,Phase 3
35 Antirheumatic Agents Phase 4,Phase 3,Phase 2
36 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2
37 Autonomic Agents Phase 4
38 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
39 Anti-Bacterial Agents Phase 4
40 Antibiotics, Antitubercular Phase 4
41 Folate Nutraceutical Phase 4,Phase 2
42 Vitamin B9 Nutraceutical Phase 4,Phase 2
43 Immunoglobulins Phase 3,Phase 2
44 Antibodies Phase 3,Phase 2
45 Pharmaceutical Solutions Phase 3
46 Immunoglobulin G Phase 3
47 gamma-Globulins Phase 3
48 Immunoglobulins, Intravenous Phase 3
49 Rho(D) Immune Globulin Phase 3
50
Abatacept Approved Phase 2 332348-12-6 10237

Interventional clinical trials:

(show all 37)
id Name Status NCT ID Phase
1 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4
2 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4
3 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Not yet recruiting NCT03164473 Phase 4
4 A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis Completed NCT02020889 Phase 3
5 Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Completed NCT00647166 Phase 3
6 Rituximab in Eosinophilic Granulomatosis With Polyangiitis Recruiting NCT02807103 Phase 3
7 Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES) Recruiting NCT02836496 Phase 3
8 Intravenous Immunoglobulin After Relapse in Vasculitis Terminated NCT00307658 Phase 3
9 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides Unknown status NCT00751517 Phase 2
10 Mepolizumab As a Steroid-sparing Treatment Option in the Churg Strauss Syndrome Completed NCT00527566 Phase 1, Phase 2
11 Safety and Efficacy Study of Mepolizumab in Churg Strauss Syndrome Completed NCT00716651 Phase 2
12 Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic Syndrome Completed NCT00266565 Phase 1, Phase 2
13 Steroids and Methotrexate to Treat Systemic Vasculitis Completed NCT00001256 Phase 2
14 Benralizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Recruiting NCT03010436 Phase 2
15 Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Not yet recruiting NCT02947945 Phase 2
16 Rituxan in Churg Strauss Syndrome With Renal Involvement Terminated NCT00424749 Phase 2
17 Abatacept in ANCA Associated Vasculitis Terminated NCT00482066 Phase 2
18 Hematopoietic Stem Cell Support in Vasculitis Terminated NCT00278512 Phase 1
19 PRO Development for ANCA Associated Vasculitis Unknown status NCT01729624
20 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055
21 RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides Completed NCT00307593
22 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
23 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
24 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
25 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
26 Eosinophilic Granulomatosis With Polyangiitis Cohort Recruiting NCT03036670
27 Determining Disease Activity Biomarkers in Individuals With Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Recruiting NCT00315380
28 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Recruiting NCT01066208
29 Pediatric Vasculitis Initiative Recruiting NCT02006134
30 VCRC Tissue Repository Recruiting NCT02967068
31 Vasculitis Pregnancy Registry Recruiting NCT02593565
32 One-Time DNA Study for Vasculitis Recruiting NCT01241305
33 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
34 Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis) Recruiting NCT01862068
35 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Active, not recruiting NCT01663129
36 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
37 Immuno-ablation With Chemoimmunoradiation and Autologous Stem Cell Transplant for Churg-Strauss Syndrome Not yet recruiting NCT02728271 Early Phase 1

Search NIH Clinical Center for Churg-Strauss Syndrome

Cochrane evidence based reviews: churg-strauss syndrome

Genetic Tests for Churg-Strauss Syndrome

Anatomical Context for Churg-Strauss Syndrome

MalaCards organs/tissues related to Churg-Strauss Syndrome:

39
Lung, Heart, T Cells, Liver, Colon, Endothelial, Neutrophil

Publications for Churg-Strauss Syndrome

Articles related to Churg-Strauss Syndrome:

(show top 50) (show all 634)
id Title Authors Year
1
Clinical Characteristics and Treatment Response of Peripheral Neuropathy in the Presence of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Experience at a Single Tertiary Center. ( 28079316 )
2017
2
A Case of Churg-Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis (EGPA)) of the Urinary Bladder. ( 28477943 )
2017
3
Low Median Nerve Palsy as Initial Manifestation of Churg-Strauss Syndrome. ( 28089164 )
2017
4
Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome) as a differential diagnosis of hypereosinophilic syndromes. ( 28337408 )
2017
5
Multiple Thromboembolic Cerebral Infarctions from the Aorta in a Patient with Churg-Strauss Syndrome. ( 27993446 )
2017
6
ANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report. ( 28065613 )
2017
7
Omalizumab-associated eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28094120 )
2017
8
Churg-Strauss Syndrome: Singulair or Silicone (or both?). ( 27228637 )
2016
9
Not All Coughs Are Asthma or Allergies: Churg-Strauss Syndrome. ( 27431867 )
2016
10
A patient with Churg-Strauss syndrome complicated with pulmonary hemoptysis. ( 27041254 )
2016
11
Churg-Strauss syndrome with endocardial injury, clot formation in heart's chambers, and neurological complications. ( 27910080 )
2016
12
A case report and literature review of Churg-Strauss syndrome presenting with myocarditis. ( 28002315 )
2016
13
A case of hemorrhagic cholecystitis associated with Churg-Strauss syndrome. ( 26853987 )
2016
14
Churg Strauss syndrome formes frustes: A case report. ( 27728665 )
2016
15
Erratum to: Bowel perforations in a patient affected by Churg-Strauss syndrome under high-dose steroid treatment: will alternative drugs reduce risk of surgery? ( 26740233 )
2016
16
Echocardiographic Changes in Eosinophilic Endocarditis Induced by Churg-Strauss Syndrome. ( 27725542 )
2016
17
Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis. ( 26767873 )
2016
18
Churg-Strauss syndrome in a pediatric patient presenting with recurrent hemorrhagic stroke and mitral regurgitation due to a prolapsed mitral valve. ( 27381148 )
2016
19
Optimal therapy and prospects for new medicines in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 27191665 )
2016
20
Native T1 Mapping Demonstrating Apical Thrombi in Eosinophilic Myocarditis Associated with Churg-Strauss Syndrome. ( 27826352 )
2016
21
Churg-Strauss syndrome associated with antiphospholipid antibodies in a patient with retinal vasculitis. ( 27068137 )
2016
22
Polyneuropathy with demyelinating changes in Churg-Strauss syndrome: an unusual association. ( 28025723 )
2016
23
Churg-Strauss syndrome occurring during omalizumab treatment. ( 27708948 )
2015
24
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) presenting with polyneuropathy--a case series. ( 25695917 )
2015
25
A Case Report of Churg-Strauss Syndrome Presenting With Cardiogenic Shock Treated With Extracorporeal Membrane Oxygenation. ( 26512570 )
2015
26
Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a multicenter, double-blind trial. ( 25577176 )
2015
27
Churg-Strauss syndrome from an orthopaedic perspective. ( 26634374 )
2015
28
Cardiac involvement of churg-strauss syndrome as a reversible cause of dilated cardiomyopathy. ( 25883756 )
2015
29
Development of eosinophilic granulomatosis with poliangiitis (Churg-Strauss syndrome) and brain tumor in a patient after more than 7 years of omalizumab use: A case report. ( 25816417 )
2015
30
Churg-Strauss syndrome. ( 25500434 )
2015
31
An atypical caseof Churg-Strauss syndrome. ( 25686653 )
2015
32
Churg-Strauss syndrome with asymptomatic pulmonary emboli. ( 25751349 )
2015
33
Coronary involvement in Churg-Strauss syndrome. ( 26702692 )
2015
34
Letter to the editor: Colonic findings in a patient with relapse of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 25795174 )
2015
35
Noncorticosteroid immunosuppression limits myocardial damage and contractile dysfunction in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 25572517 )
2015
36
Montelukast-associated Churg-Strauss syndrome with mononeuritis multiplex. ( 26425022 )
2015
37
Nasal dermoplasty for recurrent polyps in a patient with churg-strauss syndrome. ( 25692061 )
2015
38
Unfavorably Altered Fibrin Clot Properties in Patients with Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Association with Thrombin Generation and Eosinophilia. ( 26540111 )
2015
39
Eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): where are we now? ( 26521277 )
2015
40
Churg-Strauss Syndrome as an Unusual Cause of Dysphagia: Case Report. ( 26161355 )
2015
41
Small bowel involvement documented by capsule endoscopy in Churg-Strauss syndrome. ( 26664542 )
2015
42
Familial Churg-Strauss Syndrome in a Sister and Brother. ( 26546904 )
2015
43
Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature. ( 25070496 )
2014
44
Refractory warm IgM-mediated autoimmune hemolytic anemia associated with Churg-Strauss syndrome responsive to eculizumab and rituximab. ( 24942207 )
2014
45
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. ( 24158754 )
2014
46
Modulation of MMP-2 and MMP-9 in Churg-Strauss syndrome respiratory mucosa: potential monitoring parameters. ( 25004843 )
2014
47
Usefulness of cardiac resonance imaging in Churg-Strauss syndrome. ( 25000251 )
2014
48
Churg-Strauss syndrome masquerading as an acute coronary syndrome: a case report. ( 25178849 )
2014
49
Eosinophilic leukocytoclastic vasculitis - a spectrum ranging from Wells' syndrome to Churg-Strauss syndrome? ( 25115356 )
2014
50
Ileal perforation in a young female with churg-strauss syndrome. ( 24401524 )
2014

Variations for Churg-Strauss Syndrome

Expression for Churg-Strauss Syndrome

Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for Churg-Strauss Syndrome

Pathways related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 CCL17 CCL26 CD40LG IL10 IL5 TNF
2
Show member pathways
13.05 CCL17 CCL26 CD40LG IL10 IL5 TNF
3
Show member pathways
12.57 CD40LG IL10 IL5 RNASE3 TNF
4 12.33 CD40LG IL10 MPO TNF
5
Show member pathways
12.17 CD40LG IL10 IL5 TNF
6
Show member pathways
12.03 CD40LG IL10 TNF
7
Show member pathways
11.95 IL10 IL5 TNF
8 11.63 IL10 IL5 MPO TNF
9 11.6 IL10 IL5 TNF
10
Show member pathways
11.55 CD40LG IL5 TNF
11 11.53 IL10 THBD TNF
12 11.3 CD40LG IL10 IL5 TNF
13 11.27 CD40LG IL10 TNF
14 11.22 CCL17 IL10 IL5
15 10.99 IL10 IL5
16 10.97 IL10 IL5 TNF
17 10.82 CCL17 CCL26 CD40LG IL10 IL5
18 10.76 MPO TNF
19 10.66 CCL17 CCL26 CD40LG IL10 IL5 TNF

GO Terms for Churg-Strauss Syndrome

Cellular components related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL17 CCL26 CD40LG IL10 IL5 MPO
2 cell surface GO:0009986 9.56 CD40LG GHSR THBD TNF
3 azurophil granule lumen GO:0035578 9.33 MPO PRTN3 RNASE3
4 extracellular space GO:0005615 9.32 CCL17 CCL26 CD40LG IL10 IL5 MPO

Biological processes related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.75 CCL17 CCL26 TNF
2 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.69 IL10 IL5 TNF
3 defense response to bacterium GO:0042742 9.62 IL10 MPO RNASE3 TNF
4 lymphocyte chemotaxis GO:0048247 9.59 CCL17 CCL26
5 positive regulation of cytokine secretion GO:0050715 9.58 IL10 TNF
6 negative regulation of mitotic cell cycle GO:0045930 9.57 IL10 TNF
7 negative regulation of interleukin-6 production GO:0032715 9.56 IL10 TNF
8 response to food GO:0032094 9.55 GHSR MPO
9 negative regulation of myoblast differentiation GO:0045662 9.54 CCL17 TNF
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.52 IL10 TNF
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL10 TNF
12 positive regulation of podosome assembly GO:0071803 9.48 IL5 TNF
13 endothelial cell apoptotic process GO:0072577 9.46 IL10 TNF
14 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.43 GHSR IL10
15 immune response GO:0006955 9.43 CCL17 CCL26 CD40LG IL10 IL5 TNF
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.4 IL10 TNF
17 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
18 negative regulation of growth of symbiont in host GO:0044130 9.33 IL10 MPO TNF
19 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
20 inflammatory response GO:0006954 9.1 CCL17 CCL26 CD40LG IL10 IL5 TNF

Molecular functions related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL17 CCL26 CD40LG IL10 IL5 TNF
2 CCR chemokine receptor binding GO:0048020 8.96 CCL17 CCL26

Sources for Churg-Strauss Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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