CSS
MCID: CHR001
MIFTS: 59

Churg-Strauss Syndrome (CSS) malady

Immune diseases, Cardiovascular diseases categories

Summaries for Churg-Strauss Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Churg strauss syndrome is a rare autoimmune condition characterized by asthma, high levels of eosinophils (a type of white blood cell that helps fight infection) in the blood and tissues, and inflammation of small to medium sized blood vessels (vasculitis). the inflamed vessels can affect various organ systems including the lungs, gastrointestinal tract, skin, heart and nervous system. the cause of churg strauss syndrome is unknown. while there is no cure, the condition can be successfully managed with early diagnosis and treatment. last updated: 4/4/2011

MalaCards: Churg-Strauss Syndrome, also known as churg-strauss vasculitis, is related to asthma and vasculitis, and has symptoms including asthma An important gene associated with Churg-Strauss Syndrome is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Selected targets of GCR-alpha and Allograft rejection. The compounds rantes and lte4 have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and skin, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

Wikipedia:63 Churg–Strauss syndrome (also known as eosinophilic granulomatosis with polyangiitis [EGPA] or allergic... more...

Aliases & Classifications for Churg-Strauss Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Cardiovascular diseases


Aliases & Descriptions:

churg-strauss syndrome 8 10 44 60
churg-strauss vasculitis 8 42
allergic angiitis and granulomatosis 42
allergic granulomatous and angiitis 42
allergic granulomatosis angiitis 8
allergic granulomatous angiitis 8
allergic granulomatosis 42
churg strauss syndrome 42
coffin-siris syndrome 60
css 42


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Disease Ontology8 DOID:3049
SNOMED-CT56 195362002, 82275008
NCIt39 C34481

Related Diseases for Churg-Strauss Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.3CYSLTR1, RNASE3
2vasculitis31.2MPO, PRTN3, LTF, CYSLTR1, THBD, SULT1A3
3wegener's granulomatosis31.2PRTN3, MPO
4polyarteritis nodosa31.1LTF, PRTN3, MPO
5eosinophilia30.9CCL11, CCL26, CCL17, MPO, PRTN3, IGHE
6eosinophilic pneumonia30.8CCL11, CCL17, IGHE, RNASE3, IL5
7pneumonia30.8CCL11, CCL17, DDR1, MPO, IL5, AVP
8mononeuritis multiplex30.8MPO, PRTN3
9chronic eosinophilic pneumonia30.8CCL11, RNASE3, IL5
10hepatitis30.7CCL11
11rapidly progressive glomerulonephritis30.6MPO, PRTN3
12myocardial infarction30.6SULT1A3, CCL11
13obesity30.6SULT1A3, CCL11
14hepatitis c30.5PRTN3
15mononeuropathy30.5PRTN3, MPO
16prostatitis30.5LTF
17antiphospholipid syndrome30.5THBD, SULT1A3
18arthritis30.5MPO, PRTN3, LTF, SULT1A3
19allergic bronchopulmonary aspergillosis30.5IGHE, IL5
20crohn's disease30.3LTF
21uveitis30.3CCL11
22candidiasis30.3LTF
23hepatitis b30.2LTF, SULT1A3
24nephrotic syndrome30.2CCL11
25urticaria30.2IGHE, RNASE3
26hypersensitivity vasculitis30.2MPO, PRTN3
27acute myocardial infarction30.2SULT1A3, THBD
28esophagitis30.2CCL11, CCL26, IL5
29eosinophilic gastroenteritis30.2IL5, IGHE, CCL11
30otitis media30.2RNASE3, LTF, IGHE, CCL11
31dermatitis30.2CCL11, CCL17, IGHE, IL5
32multiple sclerosis30.2KLRK1, CCL11, IL5
33bullous pemphigoid30.2CCL11, CCL17, IGHE, RNASE3, IL5
34allergic asthma30.2CCL11, CCL26, CCL17, IGHE, RNASE3, IL5
35rheumatoid arthritis30.2KLRK1, CCL11, HLA-DRB4, MPO, PRTN3, LTF
36melanoma30.2KLRK1, CCL11, TNFRSF10C, PRTN3, LTF, LAMP1
37neuropathy10.8
38image syndrome10.8
39granulomatous angiitis10.7
40retinitis10.7
41glomerulonephritis10.7
42retinal artery occlusion10.7
43central retinal artery occlusion10.6
44myocarditis10.6
45peripheral neuropathy10.6
46mononeuritis10.6
47cerebritis10.6
48cholecystitis10.6
49endomyocardial fibrosis10.5
50polyneuropathy10.5

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to churg-strauss syndrome

Clinical Features for Churg-Strauss Syndrome

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8Disease Ontology
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Symptoms:

8
  • asthma

Drugs & Therapeutics for Churg-Strauss Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Churg-Strauss Syndrome

Drug clinical trials:

Search ClinicalTrials for Churg-Strauss Syndrome

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Search CenterWatch for Churg-Strauss Syndrome

Genetic Tests for Churg-Strauss Syndrome

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Anatomical Context for Churg-Strauss Syndrome

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32MalaCards
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MalaCards organs/tissues related to Churg-Strauss Syndrome:

32
Lung, Heart, Skin, T cells, Liver, Colon, Endothelial, Small intestine, Prostate, Kidney, Bone, Breast, Brain, Spinal cord, Retina, Testes, Salivary gland

Animal Models for Churg-Strauss Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Churg-Strauss Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.4CCL11, DDR1, MPO, IGHE, LTF, IL25
2MP:00053878.8THBD, KLRK1, CCL11, CCL17, DDR1, MPO

Publications for Churg-Strauss Syndrome

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50PubMed
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Articles related to Churg-Strauss Syndrome:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. (24158754)
2014
2
Churg-Strauss syndrome: remember cardiac complications too. (23760718)
2013
3
Standard and feature tracking magnetic resonance evidence of myocardial involvement in Churg-Strauss syndrome and granulomatosis with polyangiitis (Wegener's) in patients with normal electrocardiograms and transthoracic echocardiography. (23212274)
2013
4
Cutting edge issues in the Churg-Strauss syndrome. (21380944)
2013
5
Churg-Strauss syndrome with endobronchial eosinophilic vasculitis. (23154742)
2012
6
12-hydroxy-eicosatetraenoic acid (12-HETE): a biomarker of Churg-Strauss syndrome. (22417211)
2012
7
Churg-Strauss syndrome with neurologic manifestations: successful treatment with intravenous immunoglobulins. (23101425)
2012
8
Impaired cardiovascular autonomic nervous system function in patients with Churg-Strauss syndrome. (21366384)
2011
9
Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-CI^ gene rearrangement. (20680375)
2011
10
Churg-Strauss syndrome in childhood: a rare form of systemic vasculitis posing a great diagnostic challenge. (21385552)
2011
11
Churg-strauss syndrome without respiratory symptoms in a child. (21572801)
2011
12
A fatal case of Churg-Strauss syndrome presenting with acute polyneuropathy mimicking Guillain-BarrAc syndrome. (21533561)
2011
13
Kampo medicines improved blood test and QOL in two vasculitis cases of Churg-Strauss syndrome and Henoch-ShAPnlein purpura after inadequate treatment with conventional therapies. (20463826)
2010
14
Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome. (20513524)
2010
15
Churg-Strauss syndrome versus chronic eosinophilic pneumonia on high-resolution computed tomographic findings. (20118716)
2010
16
Churg-Strauss syndrome secondary to antileucotriene therapy in a patient not receiving oral corticosteroids. (19747303)
2009
17
Churg-Strauss syndrome: a rare presentation with otological and pericardial manifestations: case report and review of the literature. (19225706)
2009
18
An unusual manifestation in a patient with Churg-Strauss syndrome: isolated cardiac septum involvement. (19879791)
2009
19
Rhinologic symptoms and quality-of-life in patients with Churg-Strauss syndrome vasculitis. (18702907)
2008
20
Phrenic nerve palsy in a patient of Churg Strauss syndrome and mononeuritis multiplex. (17786498)
2008
21
Embolization of a right gastroepiploic artery pseudoaneurysm associated with Churg-Strauss syndrome. (18341968)
2008
22
Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patients. (18240234)
2008
23
A phase II study of interferon-alpha for the treatment of refractory Churg-Strauss syndrome. (18799051)
2008
24
Peripheral neuropathy in Wegener's granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis. (17299018)
2007
25
Churg-Strauss syndrome: still a clinical challenge. (20477130)
2007
26
Churg-Strauss syndrome revealed by granulomatous acute pericarditis: two case reports and a review of the literature. (17303217)
2007
27
The common allergens in the Churg-Strauss syndrome. (17919144)
2007
28
Topical steroids in the management of Churg-Strauss syndrome involving the conjunctiva. (17457205)
2007
29
Multiple tracheobronchial mucosal lesions in two cases of Churg-Strauss syndrome. (16423211)
2006
30
Initial cutaneous manifestations consistent with mononeuropathy multiplex in Churg-Strauss syndrome. (16027304)
2005
31
Vasospastic angina pectoris associated with Churg-Strauss syndrome. (16265589)
2005
32
Churg Strauss syndrome--successful induction of remission with methotrexate and unexpected high cardiac and pulmonary relapse ratio during maintenance treatment. (15675136)
2004
33
Churg-Strauss syndrome associated with the leukotriene antagonist montelukast. (15060812)
2004
34
Bilateral chronic anterior uveitis & neuro-ophthalmologic manifestations in a patient with Churg-Strauss syndrome: an unusual ocular presentation. (15209465)
2004
35
Long term effectiveness of intravenous immunoglobulin in Churg-Strauss syndrome. (15547090)
2004
36
Churg-strauss syndrome. (16088497)
2004
37
A limited form of Churg-Strauss syndrome presenting without asthma and eosinophilia. (15516195)
2004
38
Endomyocardial fibrosis in Churg-Strauss syndrome. (14743851)
2004
39
Montelukast-associated Churg-Strauss syndrome. (12958007)
2003
40
Churg-Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists. (12967693)
2003
41
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis. (12418444)
2002
42
Churg-Strauss syndrome with critical endomyocardial fibrosis: 10 year survival after combined surgical and medical management. (11997435)
2002
43
Hepatitis C virus infection with and without cryoglobulinemia as a case of Churg-Strauss syndrome. (10743831)
2000
44
Simultaneous presence of C-ANCA and P-ANCA in a patient with concurrent Churg-Strauss syndrome and giant cell temporal arteritis. (10722262)
2000
45
A case of Churg-Strauss syndrome presenting with cortical blindness. (10941817)
2000
46
IgA glomerulonephritis associated with microscopic polyangiitis or Churg-Strauss syndrome. (10442496)
1999
47
Inflammatory cells and cellular activation in the lower respiratory tract in Churg-Strauss syndrome. (10456969)
1999
48
Churg-Strauss syndrome presenting with pulmonary capillaritis and diffuse alveolar hemorrhage. (9645420)
1998
49
Churg-Strauss syndrome associated with necrotizing crescentic glomerulonephritis in a diabetic patient. (9058106)
1997
50
A case of Churg-Strauss syndrome in which MPO-ANCA (antibodies to myeloperoxidase) appeared to reflect the disease activity]. (7609341)
1995

Genetic Variations for Churg-Strauss Syndrome

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Expression for genes affiliated with Churg-Strauss Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Churg-Strauss Syndrome

Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for genes affiliated with Churg-Strauss Syndrome

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12EMD Millipore, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2THBD, IL5, CCL11
2
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10.0CCL11, HLA-DRB4, RNASE3, IL5
3
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9.9CCL11, CCL26, CCL17, TNFRSF10C, IL5
49.9IL5, IGHE, CCL17, CCL26, CCL11
5
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9.8KLRK1, CCL11, TNFRSF10C, IGHE, IL5
6
Hide members
9.8CCL11, CCL26, CCL17, TNFRSF10C, DDR1, IL5
7
Hide members
9.8CCL11, CCL26, CCL17, TNFRSF10C, DDR1, IL5
8
Hide members
9.8IL5, DDR1, TNFRSF10C, CCL17, CCL26, CCL11
9
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9.6CCL11, CCL26, CCL17, TNFRSF10C, DDR1, IL25

Compounds for genes affiliated with Churg-Strauss Syndrome

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1rantes4410.5CHIA, CCL11, RNASE3
2lte44410.5RNASE3, CYSLTR1, CCL11, IL5
3beclomethasone dipropionate4410.5CYSLTR1, IGHE, RNASE3, IL5
4pranlukast44 28 1112.5IL5, RNASE3, CYSLTR1, CCL11
55-oxoete4410.5IL5, CCL11, CYSLTR1
6heparin44 28 11 2413.5LTF, CCL11, MPO, RNASE3
7unicap4410.5IGHE, RNASE3, IL5, CCL11
8pge24410.5CCL11, CYSLTR1
9toluene diisocyanate4410.5IL5, RNASE3, IGHE
10anti-histamine4410.5CCL11, RNASE3, IGHE
11ltc44410.4CCL11, RNASE3, CYSLTR1, IL5
12sodium cromoglycate4410.4CCL11, IGHE, IL5, RNASE3
13nedocromil sodium4410.4IGHE, RNASE3, IL5
14percoll4410.4PRTN3, LTF, RNASE3, IL5
15roxithromycin44 28 1112.4IL5, CCL11, CCL17
16cetirizine44 28 11 2413.4IL5, CCL11, IGHE, RNASE3
17ketotifen44 1111.4CCL11, IGHE, RNASE3, IL5
18cytochalasin b4410.4MPO, RNASE3, LTF, PRTN3
19montelukast44 49 28 1113.4CCL11, IL5, RNASE3, CYSLTR1, IGHE
20salbutamol44 49 28 11 2414.4CCL11, CYSLTR1, RNASE3, IL5, IGHE
21theophylline44 28 11 2413.4THBD, CYSLTR1, RNASE3, IL5
22fluticasone propionate44 49 59 1113.4MPO, RNASE3, CCL11, IGHE, IL5
23pgd24410.3IL5, CYSLTR1, IGHE, CCL11, RNASE3
24praziquantel44 1111.3IL5, IGHE, RNASE3
25salmeterol44 49 28 1113.3RNASE3, IL5, CCL11
26capsaicin44 2811.3RNASE3, LTF, IL5, IGHE
27leukotriene b444 59 2412.3RNASE3, CYSLTR1, LTF, MPO, CCL11, IL5
28allergens4410.3IL5, CCL11, CCL17, RNASE3, IGHE
29tarc4410.3IL5, IGHE, CCL17, CCL26, CCL11
30budesonide44 49 1112.3MPO, IGHE, LTF, RNASE3, CCL11, IL5
31methacholine44 1111.3LTF, IGHE, MPO, CCL11, IL5, RNASE3
32hyaluronic acid44 2411.3THBD, CCL11, RNASE3, LTF, PRTN3
33prednisolone44 28 1112.2MPO, THBD, IL5, RNASE3, CCL11, IGHE
34fmlp4410.2MPO, LTF, IL5, CCL11, RNASE3, PRTN3
35n-formylmethionyl-leucylphenylalanine4410.2MPO, IL5, RNASE3, THBD, LTF, PRTN3
36aspirin44 49 28 2413.2SULT1A3, THBD, CYSLTR1, CCL11, RNASE3
37indomethacin44 59 28 1113.2MPO, IGHE, IL5, CYSLTR1, CCL11, LTF
38dmso4410.2PRTN3, THBD, LAMP1, MPO, IL5
39clarithromycin44 1111.2IL5, LTF, CCL11
40azelastine44 1111.1RNASE3, IGHE, IL5
41ltd44410.1CYSLTR1, RNASE3, IL5
42cyclosporin a44 28 5912.1LTF, CCL11, CCL17, IGHE, IL5, THBD
43histamine44 28 2412.1MPO, THBD, CCL11, IGHE, RNASE3, CYSLTR1
44creatinine4410.1MPO, IGHE, LTF, RNASE3, AVP, THBD
45retinoic acid44 2410.9PRTN3, MPO, IGHE, CCL11, KLRK1, RNASE3
46dexamethasone44 49 28 1112.9LTF, CYSLTR1, THBD, CCL11, CCL17, AVP
47vegf449.8LTF, MPO, IGHE, CCL11, RNASE3, IL5
48arginine449.8THBD, AVP, SULT1A3, IL5, RNASE3, KLRK1
49calcium44 49 11 2412.5CCL11, PRTN3, CYSLTR1, MPO, CCL17, DDR1
50nitric oxide44 11 2411.5THBD, CCL11, CCL17, MPO, RNASE3, AVP

GO Terms for genes affiliated with Churg-Strauss Syndrome

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16Gene Ontology
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Cellular components related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.9MPO, LTF, AVP
2integral to plasma membraneGO:0058879.7LAMP1, THBD, CYSLTR1, DDR1, HLA-DRB4, TNFRSF10C
3extracellular spaceGO:0056159.6AVP, CCL11, CCL26, CCL17, MPO, CHIA
4extracellular regionGO:0055769.5CCL11, CCL17, DDR1, IGHE, LTF, RNASE3

Biological processes related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory response to antigenic stimulusGO:00243710.2IL25, HLA-DRB4
2chemotaxisGO:00693510.1CYSLTR1, CCL17, CCL26, CCL11
3response to fungusGO:00962010.1IL25, CHIA
4inflammatory responseGO:00695410.0CCL11, CCL26, CCL17, CYSLTR1, IL5
5branching involved in mammary gland duct morphogenesisGO:0604449.9DDR1, CCL11
6immune responseGO:0069559.8IL5, CCL11, CCL26, CCL17, HLA-DRB4, CHIA

Molecular functions related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.1CCL17, CCL26, CCL11

Products for genes affiliated with Churg-Strauss Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Churg-Strauss Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet