CSS
MCID: CHR001
MIFTS: 57

Churg-Strauss Syndrome (CSS) malady

Rare diseases, Cardiovascular diseases, Immune diseases categories

Summaries for Churg-Strauss Syndrome

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Churg strauss syndrome is a rare autoimmune condition characterized by asthma, high levels of eosinophils (a type of white blood cell that helps fight infection) in the blood and tissues, and inflammation of small to medium sized blood vessels (vasculitis). the inflamed vessels can affect various organ systems including the lungs, gastrointestinal tract, skin, heart and nervous system. the cause of churg strauss syndrome is unknown. while there is no cure, the condition can be successfully managed with early diagnosis and treatment. last updated: 4/4/2011

MalaCards: Churg-Strauss Syndrome, also known as churg-strauss vasculitis, is related to asthma and polyarteritis nodosa, and has symptoms including asthma An important gene associated with Churg-Strauss Syndrome is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Selected targets of GCR alpha and IL4-mediated signaling events. The compounds mometasone furoate and unicap have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and skin, and related mouse phenotype immune system.

Disease Ontology:9 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

Wikipedia:66 Churg?Strauss syndrome (CSS, also known as eosinophilic granulomatosis with polyangiitis [EGPA] or... more...

Aliases & Classifications for Churg-Strauss Syndrome

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63UMLS, 9Disease Ontology, 11DISEASES, 46Novoseek, 44NIH Rare Diseases, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Immune diseases


Aliases & Descriptions:

churg-strauss syndrome 9 11 46 63
churg-strauss vasculitis 9 44
eosinophilic granulomatous vasculitis 44
allergic angiitis and granulomatosis 44
allergic granulomatous and angiitis 44
allergic granulomatosis angiitis 9
allergic granulomatous angiitis 9
granulomatous allergic angiitis 44
allergic granulomatosis 44
churg strauss syndrome 44
coffin-siris syndrome 63
css 44


External Ids:

Disease Ontology9 DOID:3049
SNOMED-CT59 82275008, 195362002
NCIt41 C34481

Related Diseases for Churg-Strauss Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.4RNASE3, IL5
2polyarteritis nodosa31.2MPO, LTF
3vasculitis31.2LTF, MPO, CYSLTR1, THBD
4eosinophilic pneumonia31.0RNASE3, IL5
5pneumonia31.0IL5, MPO
6chronic eosinophilic pneumonia31.0IL5, RNASE3
7eosinophilia30.8CYSLTR1, MPO, RNASE3, CCL26, IL5
8hypereosinophilic syndrome30.8RNASE3, IL5
9bullous pemphigoid30.4IL5, RNASE3
10esophagitis30.4CCL26, IL5
11otitis media30.4RNASE3, LTF
12septic shock30.3LTF, THBD
13rheumatoid arthritis30.2LTF, RNASE3, MPO
14microscopic polyangiitis10.9
15neuropathy10.9
16wegener's granulomatosis10.8
17granulomatous angiitis10.8
18retinitis10.7
19glomerulonephritis10.7
20eosinophilic granulomatosis with polyangiitis10.7
21granulomatosis with polyangiitis10.7
22myocarditis10.7
23peripheral neuropathy10.7
24retinal artery occlusion10.7
25central retinal artery occlusion10.6
26mononeuritis10.6
27wells syndrome10.6
28cerebritis10.6
29cholecystitis10.6
30mononeuritis multiplex10.6
31endomyocardial fibrosis10.6
32polyneuropathy10.6
33temporal arteritis10.5
34crescentic glomerulonephritis10.5
35hepatitis10.5
36aneurysm10.5
37acalculous cholecystitis10.5
38rapidly progressive glomerulonephritis10.5
39dacryoadenitis10.5
40myocardial infarction10.5
41purpura10.5
42allergic angiitis10.5
43thromboembolism10.5
44endotheliitis10.5
45hepatitis c10.4
46iga glomerulonephritis10.4
47cryoglobulinemia10.4
48focal segmental glomerulosclerosis10.4
49exophthalmos10.4
50coronary aneurysm10.4

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to churg-strauss syndrome

Symptoms for Churg-Strauss Syndrome

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9Disease Ontology
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Symptoms:

9
  • asthma

Drugs & Therapeutics for Churg-Strauss Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Churg-Strauss Syndrome

Drug clinical trials:

Search ClinicalTrials for Churg-Strauss Syndrome

Search NIH Clinical Center for Churg-Strauss Syndrome

Search CenterWatch for Churg-Strauss Syndrome

Genetic Tests for Churg-Strauss Syndrome

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Anatomical Context for Churg-Strauss Syndrome

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34MalaCards
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MalaCards organs/tissues related to Churg-Strauss Syndrome:

34
Lung, Heart, Skin, T cells, Liver, Colon, Small intestine, Endothelial, Prostate, Kidney, Bone, Testes, Breast, Spinal cord, Retina, Brain, Salivary gland

Animal Models for Churg-Strauss Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Churg-Strauss Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6LTF, IL5, MPO, CYSLTR1, THBD

Publications for Churg-Strauss Syndrome

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Sources:
53PubMed
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Articles related to Churg-Strauss Syndrome:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Endomyocardial fibrosis in patients with confirmed Churg-Strauss syndrome. (24158754)
2014
2
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
3
Coronary spasms, cardiomyopathy, and Churg-Strauss syndrome : A case report. (24065048)
2013
4
Clinical and laboratory characteristics of 19 patients with Churg-Strauss syndrome from a single South Australian centre. (23611179)
2013
5
Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome. (22640649)
2012
6
Double-balloon endoscopy-diagnosed multiple small intestinal ulcers in a Churg-Strauss syndrome patient. (22624072)
2012
7
Churg-Strauss syndrome with endobronchial eosinophilic vasculitis. (23154742)
2012
8
Churg Strauss syndrome associated with montelukast--case report. (22783603)
2012
9
Churg-Strauss syndrome presenting with acute myocarditis and cardiogenic shock. (21963398)
2012
10
Churg-Strauss syndrome manifesting as cholestasis and diagnosed by liver biopsy. (22882337)
2012
11
Cutaneous Churg-Strauss syndrome: response to dapsone therapy. (21679841)
2011
12
Cardiac magnetic resonance imaging showing complete resolution of subendocardial involvement in Churg-Strauss syndrome. (20634759)
2011
13
Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors. (21468361)
2011
14
Hepatic venous outflow obstruction complicating Churg-Strauss syndrome in a 5-year-old child. (21240017)
2011
15
Showered cortical infarctions and brain atrophy in Churg-Strauss syndrome. (21282959)
2011
16
Churg-strauss syndrome. (22345778)
2011
17
Spontaneous anterior interosseous nerve palsy with Churg-Strauss syndrome. (20458608)
2010
18
Kampo medicines improved blood test and QOL in two vasculitis cases of Churg-Strauss syndrome and Henoch-ShAPnlein purpura after inadequate treatment with conventional therapies. (20463826)
2010
19
Eosinophilia and thrombophilia in churg strauss syndrome: a clinical and pathogenetic overview. (19833618)
2010
20
Pulmonary findings in Churg-Strauss syndrome in chest X-rays and high resolution computed tomography at the time of initial diagnosis. (20623310)
2010
21
A patient with Churg-Strauss syndrome who underwent endoscopic sinus surgery under general anesthesia -A case report-. (20651999)
2010
22
A laryngeal presentation of Churg-Strauss syndrome in childhood. (19318743)
2009
23
A case of Churg-Strauss syndrome with refractory otitis media. (18384991)
2009
24
Churg-Strauss Syndrome in childhood: a clinical review. (19893067)
2009
25
Churg-Strauss syndrome presenting as acute abdomen: are gastrointestinal manifestations an indicator of poor prognosis? (20374336)
2009
26
Churg-Strauss syndrome associated with omalizumab. (18549941)
2008
27
Hypoxemia with high alveolar-arterial oxygen gradient but no lung involvement in a patient with Churg-Strauss syndrome: case report. (18336755)
2008
28
Granulomatous arteritis in cutaneous lesions of Churg-Strauss syndrome. (17381804)
2007
29
Acute coronary syndrome associated with Churg-Strauss syndrome. (18078031)
2007
30
A case of Churg-Strauss syndrome associated with antiphospholipid antibodies. (17175066)
2007
31
Remarkable effect of anticoagulation therapy in Churg-Strauss syndrome-associated neuropathy: a case report. (16834686)
2006
32
Churg-Strauss syndrome. (16612766)
2006
33
Mesalazine-induced Churg-Strauss syndrome in a patient with Crohn's disease and sclerosing cholangitis. (16859609)
2006
34
Incidence of Churg-Strauss syndrome in asthma drug users: a population-based perspective. (15940771)
2005
35
Elevated troponins and the Churg-Strauss syndrome: a case report. (15965564)
2005
36
Hepatomegaly as a rare presentation of Churg-Strauss syndrome. (16105912)
2005
37
Churg Strauss syndrome--successful induction of remission with methotrexate and unexpected high cardiac and pulmonary relapse ratio during maintenance treatment. (15675136)
2004
38
Usefulness of 18FDG/13N-ammonia PET imaging for evaluation of the cardiac damage in Churg-Strauss syndrome. (15150672)
2004
39
Churg-Strauss syndrome associated with the leukotriene antagonist montelukast. (15060812)
2004
40
Cardiac involvement of Churg Strauss syndrome demonstrated by magnetic resonance imaging. (15675140)
2004
41
Churg-strauss syndrome with cholecystitis and renal involvement. (14518684)
2003
42
The Churg Strauss syndrome (allergic granulomatous angiitis): review and update. (14625818)
2003
43
Acute cholecystitis and duodenitis associated with Churg-Strauss syndrome. (12845966)
2003
44
Effects of a nitro compound patch on neuropathy in Churg-Strauss syndrome. (12823139)
2003
45
Churg-Strauss syndrome and eosinophilic prostatitis. (19125482)
2003
46
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis. (12418444)
2002
47
Treatment of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: where do we stand? (11263763)
2001
48
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
49
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
50
Eosinophil cationic protein in a 39-year-old patient with Churg-Strauss syndrome]. (9465849)
1998

Variations for Churg-Strauss Syndrome

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Expression for genes affiliated with Churg-Strauss Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Churg-Strauss Syndrome

Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for genes affiliated with Churg-Strauss Syndrome

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Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database
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Pathways related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL5, THBD
29.4IL5, CCL26

Compounds for genes affiliated with Churg-Strauss Syndrome

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1mometasone furoate46 6210.9RNASE3, IL5
2unicap469.9RNASE3, IL5
3levocabastine46 30 1211.8RNASE3, IL5
4toluene diisocyanate469.8RNASE3, IL5
5sodium cromoglycate469.8IL5, RNASE3
611-dehydrothromboxane b2469.6THBD, RNASE3
7beclomethasone dipropionate469.6CYSLTR1, IL5, RNASE3
8lte4469.6RNASE3, IL5, CYSLTR1
9pranlukast46 30 1211.6CYSLTR1, RNASE3, IL5
10ltd4469.6RNASE3, CYSLTR1, IL5
11montelukast46 52 30 1212.6CYSLTR1, RNASE3, IL5
12ltc4469.6CYSLTR1, RNASE3, IL5
13salbutamol46 52 30 25 1213.6CYSLTR1, IL5, RNASE3
145-oxoete469.5IL5, CYSLTR1
15pgd2469.5RNASE3, CYSLTR1, IL5
16bivalirudin46 1210.5MPO, THBD
17fluticasone propionate46 52 62 1212.3RNASE3, MPO, IL5
18naphthol as-d chloroacetate469.3MPO, LTF
19hypothiocyanite46 2510.3MPO, LTF
20percoll469.2IL5, LTF, RNASE3
21theophylline46 30 25 1212.2RNASE3, CYSLTR1, THBD, IL5
22anti-fungal469.1LTF, RNASE3, IL5
23capsaicin46 3010.1RNASE3, LTF, IL5
24zymosan469.1LTF, RNASE3, MPO
25cytochalasin b469.0LTF, RNASE3, MPO
26carbohydrates469.0THBD, RNASE3, LTF
27hyaluronic acid46 259.9THBD, RNASE3, LTF
28prednisolone46 30 1210.9IL5, RNASE3, MPO, THBD
29pentoxifylline46 129.9LTF, THBD, MPO
30fluorescein46 129.9LTF, CCL26, MPO
31dextran sulfate468.9IL5, MPO, LTF
32erythromycin46 3 52 1211.9LTF, IL5, MPO
33cyclosporin a46 30 6210.6THBD, IL5, LTF, RNASE3
34budesonide46 52 1210.6IL5, RNASE3, MPO, LTF
35methacholine46 52 1210.6MPO, RNASE3, IL5, LTF
36fmlp468.5IL5, RNASE3, MPO, LTF
37endotoxin468.5THBD, LTF, RNASE3
38cyclophosphamide46 52 1210.5MPO, THBD, LTF
39indomethacin46 30 62 1211.5CYSLTR1, MPO, IL5, LTF
40creatinine468.5RNASE3, THBD, MPO, LTF
41paraffin468.4THBD, MPO, LTF, IL5
42dexamethasone46 52 30 1211.3LTF, RNASE3, IL5, CYSLTR1, THBD
43leukotriene b446 62 2510.2MPO, LTF, IL5, RNASE3, CYSLTR1
44pge2468.2CYSLTR1, MPO, IL5, LTF, RNASE3
45n-formylmethionyl-leucylphenylalanine468.1IL5, RNASE3, LTF, MPO, THBD
46heparin46 30 25 1211.1IL5, MPO, THBD, LTF, RNASE3
47h2o2468.1MPO, LTF, IL5, RNASE3, THBD
48vegf468.1IL5, MPO, LTF, THBD, RNASE3
49retinoic acid46 259.0RNASE3, IL5, THBD, LTF, MPO
50histamine46 30 259.7THBD, CYSLTR1, RNASE3, IL5, LTF, MPO

GO Terms for genes affiliated with Churg-Strauss Syndrome

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17Gene Ontology
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Cellular components related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.0LTF, MPO
2extracellular spaceGO:0056157.2LTF, IL5, CCL26, MPO, THBD

Biological processes related to Churg-Strauss Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.4MPO, THBD
2defense responseGO:0069529.3MPO, CYSLTR1
3chemotaxisGO:0069359.2CCL26, CYSLTR1
4inflammatory responseGO:0069549.0IL5, CCL26, CYSLTR1

Products for genes affiliated with Churg-Strauss Syndrome

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  • Antibodies
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Sources for Churg-Strauss Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet