MCID: CHR001
MIFTS: 47

Churg-Strauss Syndrome

Categories: Cardiovascular diseases, Immune diseases

Aliases & Classifications for Churg-Strauss Syndrome

MalaCards integrated aliases for Churg-Strauss Syndrome:

Name: Churg-Strauss Syndrome 12 52 42 14 69
Allergic Granulomatosis Angiitis 12
Allergic Granulomatous Angiitis 12
Churg-Strauss Vasculitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3049
ICD10 33 M30.1
MeSH 42 D015267
NCIt 47 C34481
SNOMED-CT 64 195362002 82275008
UMLS 69 C0008728

Summaries for Churg-Strauss Syndrome

Disease Ontology : 12 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

MalaCards based summary : Churg-Strauss Syndrome, also known as allergic granulomatosis angiitis, is related to exophthalmos and purpura fulminans. An important gene associated with Churg-Strauss Syndrome is MPO (Myeloperoxidase), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Azathioprine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and heart, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Eosinophilic granulomatosis with polyangiitis (EGPA; also known as Churg-Strauss syndrome [CSS] or... more...

Related Diseases for Churg-Strauss Syndrome

Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
id Related Disease Score Top Affiliating Genes
1 exophthalmos 30.9 IL5 RNASE3
2 purpura fulminans 30.7 IL5 RNASE3
3 uveitis 29.2 CD40LG MPO TNF
4 pulmonary embolism 28.9 CD40LG IL10 TNF
5 goodpasture syndrome 28.3 CD40LG IL10 THBD TNF
6 myocardial infarction 28.2 CD40LG IL10 MPO THBD TNF
7 lymphoma 27.9 CD40LG IL10 IL5 PRTN3 TNF
8 asthma 27.8 CCL17 CCL26 CD40LG IL10 IL5 RNASE3
9 eosinophilic granulomatosis with polyangiitis 12.2
10 allergic angiitis 11.5
11 papillary follicular thyroid adenocarcinoma 10.7 IL5 RNASE3
12 vulvar disease 10.7 MPO RNASE3
13 marasmus 10.7 IL5 RNASE3
14 x-linked intellectual disability, van esch type 10.7 IL5 RNASE3
15 orbital plasma cell granuloma 10.7 IL5 RNASE3
16 winchester syndrome 10.7 IL5 RNASE3
17 allescheriosis 10.7 IL5 PRTN3
18 apple allergy 10.7 IL5 RNASE3
19 focal embolic glomerulonephritis 10.6 MPO PRTN3
20 lymphocytic gastritis 10.6 IL5 RNASE3
21 subacute bacterial endocarditis 10.6 IL5 RNASE3
22 cannabis abuse 10.6 IL5 RNASE3
23 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 10.6 CCL26 IL5
24 acute gonococcal prostatitis 10.6 IL5 RNASE3
25 trachea leiomyoma 10.6 IL5 RNASE3
26 fungal gastritis 10.6 CCL26 IL5
27 female urethral cancer 10.6 IL5 RNASE3
28 neuropathy 10.5
29 viljoen kallis voges syndrome 10.5 IL5 RNASE3
30 clostridium difficile colitis 10.5 MPO RNASE3
31 vasculitis 10.5
32 microscopic polyangiitis 10.5
33 sphenoid sinusitis 10.5 MPO PRTN3 RNASE3
34 gerstmann syndrome 10.5 IL10 PRTN3
35 polyarteritis nodosa 10.5
36 prostate calculus 10.4 PRTN3 TNF
37 autoimmune oophoritis 10.4 MPO TNF
38 inclusion conjunctivitis 10.4 IL5 PRTN3
39 migraine with brainstem aura 10.4 MPO TNF
40 skin disease 10.4 IL5 RNASE3
41 granulomatous angiitis 10.4
42 aortic arch interruption 10.4 IL5 TNF
43 retinitis 10.4
44 anencephaly and spina bifida x-linked 10.4 MPO TNF
45 glomerulonephritis 10.4
46 urethral intrinsic sphincter deficiency 10.3 IL5 TNF
47 myocarditis 10.3
48 opiate dependence 10.3 IL5 PRTN3 THBD
49 hepatic encephalopathy 10.3 IL5 TNF
50 toxic diffuse goiter 10.3 CCL17 IL5 RNASE3

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to Churg-Strauss Syndrome

Symptoms & Phenotypes for Churg-Strauss Syndrome

MGI Mouse Phenotypes related to Churg-Strauss Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CCL17 CD40LG IL10 IL5 MPO PRTN3
2 immune system MP:0005387 9.23 THBD TNF CCL17 CD40LG IL10 IL5

Drugs & Therapeutics for Churg-Strauss Syndrome

Drugs for Churg-Strauss Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4,Phase 3,Early Phase 1 446-86-6 2265
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 50-18-0, 6055-19-2 2907
3
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
6
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
7
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
8
Mycophenolic acid Approved Phase 4 24280-93-1 446541
9
rituximab Approved Phase 4,Phase 3,Phase 2,Early Phase 1 174722-31-7 10201696
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
11
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
12 Alkylating Agents Phase 4,Phase 3,Phase 2
13 Antimetabolites Phase 4,Phase 3,Phase 2
14 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
15 Antirheumatic Agents Phase 4,Phase 3,Phase 2
16 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
17 Antiemetics Phase 4
18 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
19 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
20 Autonomic Agents Phase 4
21 Dermatologic Agents Phase 4,Phase 2
22 Folic Acid Antagonists Phase 4,Phase 2
23 Gastrointestinal Agents Phase 4
24 glucocorticoids Phase 4,Phase 3,Phase 2
25 Hormone Antagonists Phase 4,Phase 3,Phase 2
26 Hormones Phase 4,Phase 3,Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
28 Methylprednisolone acetate Phase 4,Phase 3
29 Methylprednisolone Hemisuccinate Phase 4,Phase 3
30 Neuroprotective Agents Phase 4
31 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
32 Peripheral Nervous System Agents Phase 4
33 Prednisolone acetate Phase 4,Phase 3
34 Prednisolone hemisuccinate Phase 4,Phase 3
35 Prednisolone phosphate Phase 4,Phase 3
36 Protective Agents Phase 4
37 Vitamin B Complex Phase 4,Phase 2
38 Anti-Bacterial Agents Phase 4
39 Antibiotics, Antitubercular Phase 4
40 Folate Nutraceutical Phase 4,Phase 2
41 Vitamin B9 Nutraceutical Phase 4,Phase 2
42 Antibodies Phase 3,Phase 2
43 Immunoglobulins Phase 3,Phase 2
44 Pharmaceutical Solutions Phase 3
45 gamma-Globulins Phase 3
46 Immunoglobulins, Intravenous Phase 3
47 Rho(D) Immune Globulin Phase 3
48
Abatacept Approved Phase 2 332348-12-6 10237
49 Antibodies, Antineutrophil Cytoplasmic Phase 2
50 interferons Phase 1, Phase 2

Interventional clinical trials:

(show all 38)

id Name Status NCT ID Phase Drugs
1 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
2 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
3 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Not yet recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
4 A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis Completed NCT02020889 Phase 3 Placebo
5 Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Completed NCT00647166 Phase 3 corticosteroid and azathioprine;corticosteroid and placebo
6 Rituximab in Eosinophilic Granulomatosis With Polyangiitis Recruiting NCT02807103 Phase 3 Rituximab;Placebo-rituximab;Cyclophosphamide;Placebo-cyclophosphamide
7 Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES) Recruiting NCT02836496 Phase 3 Mepolizumab 300 mg;Placebo matching mepolizumab;Active OCS capsules (5 mg prednisolone or prednisone);Placebo matching OCS capsules
8 Long-term Access Program (LAP) of Mepolizumab for Subjects Who Participated in Study MEA115921 Active, not recruiting NCT03298061 Phase 3 Mepolizumab;Prednisolone
9 Intravenous Immunoglobulin After Relapse in Vasculitis Terminated NCT00307658 Phase 3 Intravenous immunoglobulins (human immunoglobulins G)
10 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides Unknown status NCT00751517 Phase 2 Methotrexate;Cyclophosphamide
11 Mepolizumab As a Steroid-sparing Treatment Option in the Churg Strauss Syndrome Completed NCT00527566 Phase 1, Phase 2
12 Safety and Efficacy Study of Mepolizumab in Churg Strauss Syndrome Completed NCT00716651 Phase 2 mepolizumab
13 Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic Syndrome Completed NCT00266565 Phase 1, Phase 2 Mepolizumab
14 Steroids and Methotrexate to Treat Systemic Vasculitis Completed NCT00001256 Phase 2 prednisone and methotrexate
15 Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Recruiting NCT02947945 Phase 2 Reslizumab
16 Benralizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Recruiting NCT03010436 Phase 2 Benralizumab
17 Rituxan in Churg Strauss Syndrome With Renal Involvement Terminated NCT00424749 Phase 2 Rituximab;Prednisone
18 Abatacept in ANCA Associated Vasculitis Terminated NCT00482066 Phase 2 Abatacept (Orencia)
19 Hematopoietic Stem Cell Support in Vasculitis Terminated NCT00278512 Phase 1
20 PRO Development for ANCA Associated Vasculitis Unknown status NCT01729624
21 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
22 RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides Completed NCT00307593 Infliximab;Rituximab
23 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
24 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
25 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
26 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
27 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
28 Eosinophilic Granulomatosis With Polyangiitis Cohort Recruiting NCT03036670
29 Determining Disease Activity Biomarkers in Individuals With Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Recruiting NCT00315380
30 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Recruiting NCT01066208
31 Pediatric Vasculitis Initiative Recruiting NCT02006134
32 VCRC Tissue Repository Recruiting NCT02967068
33 Vasculitis Pregnancy Registry Recruiting NCT02593565
34 One-Time DNA Study for Vasculitis Recruiting NCT01241305
35 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
36 Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis) Recruiting NCT01862068
37 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
38 Immuno-ablation With Chemoimmunoradiation and Autologous Stem Cell Transplant for Churg-Strauss Syndrome Terminated NCT02728271 Early Phase 1

Search NIH Clinical Center for Churg-Strauss Syndrome

Cochrane evidence based reviews: churg-strauss syndrome

Genetic Tests for Churg-Strauss Syndrome

Anatomical Context for Churg-Strauss Syndrome

MalaCards organs/tissues related to Churg-Strauss Syndrome:

39
Lung, Neutrophil, Heart, T Cells, Liver, Colon, Endothelial

Publications for Churg-Strauss Syndrome

Articles related to Churg-Strauss Syndrome:

(show top 50) (show all 639)
id Title Authors Year
1
Multiple Thromboembolic Cerebral Infarctions from the Aorta in a Patient with Churg-Strauss Syndrome. ( 27993446 )
2017
2
A Case of Churg-Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis (EGPA)) of the Urinary Bladder. ( 28477943 )
2017
3
Clinical Characteristics and Treatment Response of Peripheral Neuropathy in the Presence of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Experience at a Single Tertiary Center. ( 28079316 )
2017
4
Two different causes in a patient with distal symmetric axonal polyneuropathy: Churg-Strauss syndrome and multiple myeloma, coincidental or associated with each other? ( 28332041 )
2017
5
Low Median Nerve Palsy as Initial Manifestation of Churg-Strauss Syndrome. ( 28089164 )
2017
6
Diagnosis of Churg-Strauss Syndrome Presented With Neuroendocrine Carcinoma: A Case Report. ( 28758089 )
2017
7
Eye problems in a woman with Churg-Strauss syndrome. ( 28098669 )
2017
8
Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome) as a differential diagnosis of hypereosinophilic syndromes. ( 28337408 )
2017
9
Sequential rituximab and omalizumab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28762062 )
2017
10
ANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report. ( 28065613 )
2017
11
Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome. ( 28255916 )
2017
12
Omalizumab-associated eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28094120 )
2017
13
Heart involvement in Churg-Strauss syndrome. ( 28205199 )
2017
14
Churg-Strauss syndrome associated with antiphospholipid antibodies in a patient with retinal vasculitis. ( 27068137 )
2016
15
A case of hemorrhagic cholecystitis associated with Churg-Strauss syndrome. ( 26853987 )
2016
16
Polyneuropathy with demyelinating changes in Churg-Strauss syndrome: an unusual association. ( 28025723 )
2016
17
Churg-Strauss Syndrome: Singulair or Silicone (or both?). ( 27228637 )
2016
18
Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis. ( 26767873 )
2016
19
Not All Coughs Are Asthma or Allergies: Churg-Strauss Syndrome. ( 27431867 )
2016
20
Echocardiographic Changes in Eosinophilic Endocarditis Induced by Churg-Strauss Syndrome. ( 27725542 )
2016
21
A case report and literature review of Churg-Strauss syndrome presenting with myocarditis. ( 28002315 )
2016
22
Native T1 Mapping Demonstrating Apical Thrombi in Eosinophilic Myocarditis Associated with Churg-Strauss Syndrome. ( 27826352 )
2016
23
Churg-Strauss syndrome with endocardial injury, clot formation in heart's chambers, and neurological complications. ( 27910080 )
2016
24
Optimal therapy and prospects for new medicines in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 27191665 )
2016
25
Churg-Strauss syndrome in a pediatric patient presenting with recurrent hemorrhagic stroke and mitral regurgitation due to a prolapsed mitral valve. ( 27381148 )
2016
26
A patient with Churg-Strauss syndrome complicated with pulmonary hemoptysis. ( 27041254 )
2016
27
Churg Strauss syndrome formes frustes: A case report. ( 27728665 )
2016
28
Churg-Strauss syndrome with asymptomatic pulmonary emboli. ( 25751349 )
2015
29
Churg-Strauss syndrome. ( 25500434 )
2015
30
Noncorticosteroid immunosuppression limits myocardial damage and contractile dysfunction in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 25572517 )
2015
31
Churg-Strauss syndrome occurring during omalizumab treatment. ( 27708948 )
2015
32
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) presenting with polyneuropathy--a case series. ( 25695917 )
2015
33
An atypical caseof Churg-Strauss syndrome. ( 25686653 )
2015
34
A Case Report of Churg-Strauss Syndrome Presenting With Cardiogenic Shock Treated With Extracorporeal Membrane Oxygenation. ( 26512570 )
2015
35
Cardiac involvement of churg-strauss syndrome as a reversible cause of dilated cardiomyopathy. ( 25883756 )
2015
36
Letter to the editor: Colonic findings in a patient with relapse of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 25795174 )
2015
37
Churg-Strauss syndrome from an orthopaedic perspective. ( 26634374 )
2015
38
Unfavorably Altered Fibrin Clot Properties in Patients with Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Association with Thrombin Generation and Eosinophilia. ( 26540111 )
2015
39
Eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): where are we now? ( 26521277 )
2015
40
Familial Churg-Strauss Syndrome in a Sister and Brother. ( 26546904 )
2015
41
Nasal dermoplasty for recurrent polyps in a patient with churg-strauss syndrome. ( 25692061 )
2015
42
Churg-Strauss Syndrome as an Unusual Cause of Dysphagia: Case Report. ( 26161355 )
2015
43
Montelukast-associated Churg-Strauss syndrome with mononeuritis multiplex. ( 26425022 )
2015
44
Coronary involvement in Churg-Strauss syndrome. ( 26702692 )
2015
45
Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a multicenter, double-blind trial. ( 25577176 )
2015
46
Small bowel involvement documented by capsule endoscopy in Churg-Strauss syndrome. ( 26664542 )
2015
47
Development of eosinophilic granulomatosis with poliangiitis (Churg-Strauss syndrome) and brain tumor in a patient after more than 7 years of omalizumab use: A case report. ( 25816417 )
2015
48
Churg-Strauss syndrome: a new endotype of severe asthma? Results of 14 Turkish patients. ( 24761830 )
2014
49
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) presenting as diffuse myositis. ( 25414144 )
2014
50
Churg-strauss syndrome presented with hearing impairment and facial palsy. ( 25566487 )
2014

Variations for Churg-Strauss Syndrome

Expression for Churg-Strauss Syndrome

Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for Churg-Strauss Syndrome

Pathways related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 CCL17 CCL26 CD40LG IL10 IL5 TNF
2
Show member pathways
13.04 CCL17 CCL26 CD40LG IL10 IL5 TNF
3
Show member pathways
12.57 CD40LG IL10 IL5 RNASE3 TNF
4 12.33 CD40LG IL10 MPO TNF
5
Show member pathways
12.17 CD40LG IL10 IL5 TNF
6
Show member pathways
12.03 CD40LG IL10 TNF
7
Show member pathways
11.95 IL10 IL5 TNF
8 11.63 IL10 IL5 MPO TNF
9 11.6 IL10 IL5 TNF
10
Show member pathways
11.57 CD40LG IL5 TNF
11 11.53 IL10 THBD TNF
12 11.3 CD40LG IL10 IL5 TNF
13 11.27 CD40LG IL10 TNF
14 11.22 CCL17 IL10 IL5
15 10.99 IL10 IL5
16 10.97 IL10 IL5 TNF
17 10.82 CCL17 CCL26 CD40LG IL10 IL5
18 10.76 MPO TNF
19 10.66 CCL17 CCL26 CD40LG IL10 IL5 TNF

GO Terms for Churg-Strauss Syndrome

Cellular components related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL17 CCL26 CD40LG IL10 IL5 MPO
2 azurophil granule lumen GO:0035578 9.33 MPO PRTN3 RNASE3
3 extracellular space GO:0005615 9.32 CCL17 CCL26 CD40LG IL10 IL5 MPO

Biological processes related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 CCL17 CCL26 TNF
2 response to lipopolysaccharide GO:0032496 9.76 IL10 MPO THBD
3 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.69 IL10 IL5 TNF
4 defense response to bacterium GO:0042742 9.62 IL10 MPO RNASE3 TNF
5 positive regulation of cytokine secretion GO:0050715 9.58 IL10 TNF
6 negative regulation of interleukin-6 production GO:0032715 9.57 IL10 TNF
7 negative regulation of myoblast differentiation GO:0045662 9.56 CCL17 TNF
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.55 IL10 TNF
9 response to food GO:0032094 9.54 GHSR MPO
10 cellular response to lipopolysaccharide GO:0071222 9.52 IL10 TNF
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL10 TNF
12 positive regulation of podosome assembly GO:0071803 9.48 IL5 TNF
13 endothelial cell apoptotic process GO:0072577 9.46 IL10 TNF
14 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.43 GHSR IL10
15 immune response GO:0006955 9.43 CCL17 CCL26 CD40LG IL10 IL5 TNF
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.4 IL10 TNF
17 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
18 negative regulation of growth of symbiont in host GO:0044130 9.33 IL10 MPO TNF
19 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
20 inflammatory response GO:0006954 9.1 CCL17 CCL26 CD40LG IL10 IL5 TNF

Molecular functions related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL17 CCL26 CD40LG IL10 IL5 TNF

Sources for Churg-Strauss Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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