Chylomicronemia Syndrome malady

Wikipedia: Lipoprotein lipase deficiency (also known as \"chylomicronemia\", \"chylomicronemia syndrome\" and...⁴⁴ more...

MalaCards: Chylomicronemia Syndrome is related to familial lipoprotein lipase deficiency and familial hypertriglyceridemia. An important gene associated with Chylomicronemia Syndrome is APOC2 (apolipoprotein C-II), and among its related pathways are Metabolism of lipids and lipoproteins and Statin Pathway, Pharmacodynamics. The compounds trioleoylglycerol and gemfibrozil have been mentioned in the context of this disorder.

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Diseases related to chylomicronemia syndrome by text searches and GeneDecks gene sharing:

(show all 29)

id	Related Disease	Score	Top Affiliating Genes
1	familial lipoprotein lipase deficiency	28.3	LPL, APOC2
2	familial hypertriglyceridemia	28.3	APOC2, LPL
3	lipoprotein lipase deficiency	28.2	LPL, APOC2
4	acute pancreatitis	27.0	LPL, APOC2, PRSS1
5	hyperlipoproteinemia type v	12.7	APOC2, LPL
6	familial hyperlipidemia	12.7	LPL, APOC2
7	abetalipoproteinemia	12.7	APOC2, LPL
8	hyperlipoproteinemia type iii	12.7	LPL, APOC2
9	familial combined hyperlipidemia	12.6	APOC2, LPL
10	glucose intolerance	12.6	APOC2, LPL
11	hypertriglyceridemia	12.6	LPL, APOC2
12	patent ductus arteriosus	12.6	LPL, APOC2
13	cerebral infarction	12.6	APOC2, LPL
14	vascular disease	12.5	LPL, APOC2
15	hyperlipidemia	12.5	APOC2, LPL
16	chronic kidney failure	12.5	LPL, APOC2
17	alcoholic pancreatitis	12.5	LPL, PRSS1
18	hypercholesterolemia	12.4	LPL, APOC2
19	type 2 diabetes mellitus	12.4	APOC2, LPL
20	mayer-rokitansky-kuster-hauser syndrome	12.3	LPL, APOC2
21	duodenitis	12.0	PRSS1, LPL
22	steatorrhea	11.9	PRSS1, APOC2, LPL
23	hereditary pancreatitis	11.9	LPL, APOC2, PRSS1
24	hepatitis c	11.8	PRSS1, APOC2, LPL
25	diabetes mellitus	11.8	LPL, APOC2, PRSS1
26	gonococcal synovitis	11.7	LPL, APOC2, PRSS1
27	alzheimer's disease	11.5	LPL, APOC2, PRSS1
28	thyroiditis	11.2	LPL, APOC2, PRSS1
29	pancreatitis	7.0

Approved drugs:

Drug clinical trials:

Articles related to chylomicronemia syndrome:

id	Title	Authors	Year	Affiliating Genes
1	Missense mutation Leu72Pro located on the carboxyl terminal amphipathic helix of apolipoprotein C-II causes familial chylomicronemia syndrome. (16153625)	Lam C.W.... Tong S.F.	2006	APOC2
2	Recurrent acute and chronic pancreatitis in two brothers with familial chylomicronemia syndrome. (16552344)	Truninger K.... Ammann R.W.	2006	LPL, PRSS1
3	Familial chylomicronemia syndrome. (15758547)	Mohandas M.K.... George T.T.	2005	LPL
4	Chylomicronemia syndrome (11905095)	Francis A.... Levy Y.	2002	LPL, APOC2
5	Chylomicronemia syndrome in 45 years old man (11865593)	Obojski A.... MaA8olepszy J.	2001	LPL
6	Therapeutic plasma exchange in patients with chylomicronemia syndrome complicated by acute pancreatitis. (10427620)	Lennertz A.... Bosch T.	1999	LPL, APOC2
7	Therapeutic response to medium-chain triglycerides and omega-3 fatty acids in a patient with the familial chylomicronemia syndrome. (9261273)	Rouis M.... Santamarina-Fojo S.	1997	LPL

Genes related to chylomicronemia syndrome according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	APOC2	apolipoprotein C-II	11.0	Publications
2	PRSS1	protease, serine, 1 (trypsin 1)	11.0	Publications
3	LPL	lipoprotein lipase	11.0	Publications

Pathways related to chylomicronemia syndrome according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Metabolism of lipids and lipoproteins38	9.3	LPL, APOC2
2	Statin Pathway, Pharmacodynamics34	9.0	LPL, APOC2

Compounds related to chylomicronemia syndrome according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	trioleoylglycerol32	9.5	LPL, APOC2
2	gemfibrozil32 9 9	11.4	LPL, APOC2
3	triacylglycerol32	9.4	LPL, APOC2
4	sodium dodecylsulfate32	9.3	APOC2, LPL
5	phospholipid32	9.3	LPL, APOC2
6	vitamin a32 9 18 9	12.2	LPL, APOC2
7	polysaccharide32	8.8	LPL, PRSS1

Cellular components related to chylomicronemia syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chylomicron	GO:042627	9.3	LPL, APOC2
2	very-low-density lipoprotein particle	GO:034361	9.2	LPL, APOC2
3	extracellular region	GO:005576	8.5	LPL, APOC2, PRSS1
4	extracellular space	GO:005615	8.2	PRSS1, APOC2, LPL

Biological processes related to chylomicronemia syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chylomicron remodeling	GO:034371	9.4	LPL, APOC2
2	very-low-density lipoprotein particle remodeling	GO:034372	9.4	LPL, APOC2
3	triglyceride homeostasis	GO:070328	9.3	LPL, APOC2
4	response to drug	GO:042493	9.3	LPL, APOC2
5	lipoprotein metabolic process	GO:042157	9.2	APOC2, LPL
6	lipid metabolic process	GO:006629	9.0	LPL, APOC2