MCID: CCT002
MIFTS: 64

Cicatricial Pemphigoid malady

Eye diseases, Skin diseases categories

Summaries for Cicatricial Pemphigoid

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Cicatricial pemphigoid is a rare, chronic, blistering and scarring disease that affects the oral and ocular mucosa. other mucosal sites that might be affected include the nasopharnyx, larynx, genitalia, rectum, and esophagus. the condition usually begins in late adulthood (e.g. 50's or 60's), affects more women than men, and has a variable prognosis. scarring of the affected  mucosa of the eye may lead to blindness and tends to be the most feared complication. a combination of environmental and genetic factors appear to play a role in the susceptibility of developing benign mucosal pemphigoid. although the specific causes of benign mucosal pemphigoid have not been identified, the condition is considered an autoimmune disease that is characterized by the production of autoantibodies against basement membrane zone antigens such as bp180, bp230, and laminin 5.  treatment is dependent on the person's specific symptoms. last updated: 8/4/2009

MalaCards: Cicatricial Pemphigoid, also known as benign mucous membrane pemphigoid with ocular involvement, is related to bullous pemphigoid and epidermolysis bullosa. An important gene associated with Cicatricial Pemphigoid is ITGB4 (integrin, beta 4), and among its related pathways are HTLV-I infection and Cytokines and Inflammatory Response. The compounds pge2 and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are vision/eye and limbs/digits/tail.

Wikipedia:63 Cicatricial pemphigoid (also known as \"Mucous Membrane Pemphigoid\", \"MMP\", \"Benign mucosal... more...

Aliases & Classifications for Cicatricial Pemphigoid

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 48Orphanet, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Skin diseases


Aliases & Descriptions:

cicatricial pemphigoid 8 42 10
benign mucous membrane pemphigoid with ocular involvement 8 60
ocular pemphigoid 8 48
cicatricial pemphigoid with ocular involvement 8
benign mucous membrance pemphigoid 42
pemphigoid, benign mucous membrane 60
benign mucous membrane pemphigoid 8
benign mucosal pemphigoid 42
pemphigoid cicatricial 44
ocular pemphigus 8


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Disease Ontology8 DOID:11656
MeSH34 D010390
NCIt39 C34907
ICD9CM27 694.6
ICD10 via Orphanet26 H13.3*, L12+
ICD1025 H13.3, L12.1

Related Diseases for Cicatricial Pemphigoid

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17GeneCards, 18GeneDecks
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Diseases related to Cicatricial Pemphigoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1bullous pemphigoid31.3DST, ITGA6, COL17A1
2epidermolysis bullosa31.0LAMC2, DST, ITGA6, ITGB4, COL17A1
3epidermolysis bullosa acquisita30.9ITGB4, COL17A1, DST, CD79A, LAD1, LAMC2
4ocular cicatricial pemphigoid30.8CIITA, ITGA6, ITGB4
5rheumatoid arthritis30.8HLA-DRB1, CIITA
6arthritis30.8CSF1, TNF, CTGF, HLA-DRB1, CIITA, MIF
7pemphigus30.7CD79A, DST
8lichen planus30.6LAMC2, DST, COL17A1
9esophagitis30.6IL5, PRG2
10conjunctivitis30.5RNASE3, CD79A
11thyroiditis30.4CD79A, CIITA, HLA-DRB1
12periodontal disease30.4TNF, CD79A, LAMC2
13squamous cell carcinoma30.4COL17A1, ITGB4, ITGA6, DST, MIF, LAMC2
14lupus erythematosus30.4CD79A
15nephrotic syndrome30.1CD79A
16neutropenia30.1CSF1
17glaucoma30.1CTGF
18keratoconjunctivitis30.1IL5, RNASE3
19sjogren's syndrome30.1CD79A, CIITA
20dermatitis herpetiformis30.1HLA-DQB1, CD79A
21dermatitis30.1IL4, IL5, CD79A
22herpes gestationis30.1COL17A1, DST, RNASE3
23systemic lupus erythematosus30.1TNF, HLA-DQB1, HLA-DRB1, CIITA, MIF, CD79A
24gingivitis10.6
25laryngitis10.6
26periodontitis10.5
27stevens-johnson syndrome10.5
28cataract10.5
29cicatricial entropion10.4
30entropion10.4
31chronic conjunctivitis10.4
32mucous membrane pemphigoid10.4
33conjunctiva squamous cell carcinoma10.3
34sclerosing cholangitis10.3
35cholangitis10.3
36renal cell carcinoma10.3
37erythema multiforme10.3
38corneal ulcer10.3
39keratitis10.3
40brunsting-perry syndrome10.3
41munchausen by proxy10.1
42porphyria cutanea tarda10.1
43trachoma10.1
44mucoepidermoid carcinoma10.1
45alopecia10.1
46balanitis10.1
47gingival disease10.1
48herpes simplex10.1
49hodgkin's lymphoma10.1
50laryngeal carcinoma10.1

Graphical network of the top 20 diseases related to Cicatricial Pemphigoid:



Diseases related to cicatricial pemphigoid

Clinical Features for Cicatricial Pemphigoid

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Drugs & Therapeutics for Cicatricial Pemphigoid

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cicatricial Pemphigoid

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Anatomical Context for Cicatricial Pemphigoid

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32MalaCards
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MalaCards organs/tissues related to Cicatricial Pemphigoid:

32
Skin, Eye, Testes, Lung, Colon, Pancreas, T cells, Trachea

Animal Models for Cicatricial Pemphigoid or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cicatricial Pemphigoid:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.5DST, ITGB4
2MP:000537110.3CSF1, DST, SERPINH1
3MP:000536710.1HLA-DQB1, ITGB4, DST, LAMC2
4MP:00053899.9COL17A1, CSF1, DST, TGFB1
5MP:00107719.8COL17A1, CTGF, ITGB4, ITGA6, DST, TGFB1
6MP:00053959.8CSF1, ITGA6, DST, LAMC2
7MP:00036319.5CSF1, HLA-DQB1, ITGB4, ITGA6, DST, SERPINH1
8MP:00053779.5CSF1, CTGF, ITGB4, LAMC2
9MP:00053889.4TGFB1, CTGF, HLA-DQB1, ITGB4, ITGA6, PRG2
10MP:00053709.4TGFB1, IL4, IL5, HLA-DQB1, TNF, CSF1
11MP:00053799.4CSF1, TNF, ITGA6, CIITA, IL4, TGFB1
12MP:00053859.2CSF1, TNF, CTGF, HLA-DQB1, ITGB4, ITGA6
13MP:00053829.2CSF1, TNF, CTGF, ITGB4, ITGA6, IL4
14MP:00053818.9TNF, CTGF, HLA-DQB1, ITGB4, ITGA6, DST
15MP:00053848.9CSF1, TNF, CTGF, HLA-DQB1, ITGB4, ITGA6
16MP:00053788.8CTGF, TNF, CSF1, COL17A1, HLA-DQB1, ITGA6
17MP:00053768.8CSF1, TNF, CTGF, HLA-DQB1, ITGB4, CIITA
18MP:00053978.7CSF1, TNF, HLA-DQB1, ITGA6, CIITA, PRG2
19MP:00107688.5HLA-DQB1, CTGF, TNF, CSF1, COL17A1, ITGB4
20MP:00053878.3ITGA6, ITGB4, HLA-DQB1, TNF, CSF1, COL17A1

Publications for Cicatricial Pemphigoid

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50PubMed
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Articles related to Cicatricial Pemphigoid:

(show top 50)    (show all 425)
idTitleAuthorsYear
1
Ocular and oral mucous membrane pemphigoid (cicatricial pemphigoid). (22137224)
2012
2
Laser light may improve the symptoms of oral lesions of cicatricial pemphigoid: a case report. (19878031)
2009
3
Two cases of anti-epiligrin cicatricial pemphigoid with and without associated malignancy. (18779887)
2008
4
Ocular cicatricial pemphigoid. (18762085)
2008
5
Intravenous immunoglobulin therapy for refractory ocular cicatricial pemphigoid: case report. (18724167)
2008
6
A quick and simple serum test to differentiate bullous pemphigoid, epidermolysis bullosa acquisita, and anti-epiligrin cicatricial pemphigoid. (18718187)
2008
7
In vivo confocal microscopy of ocular cicatricial pemphigoid. (16583645)
2006
8
Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. (16950250)
2006
9
Vulvar cicatricial pemphigoid of childhood. (14871327)
2004
10
Ocular cicatricial pemphigoid, keratomycosis, and intravenous immunoglobulin therapy. (15502484)
2004
11
Anti-epiligrin cicatricial pemphigoid and epidermolysis bullosa acquisita: differentiation by use of indirect immunofluorescence microscopy. (12664017)
2003
12
Effects of IL-4 on conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid. (12882790)
2003
13
Cicatricial pemphigoid in non-Hodgkin's lymphoma. (12895176)
2003
14
Cicatricial pemphigoid with circulating IgA and IgG autoantibodies to the central portion of the BP180 ectodomain: beneficial effect of adjuvant therapy with high-dose intravenous immunoglobulin. (11756957)
2002
15
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
16
Cicatricial pemphigoid--a case report. (17664749)
2001
17
IgG autoantibodies in patients with anti-epiligrin cicatricial pemphigoid recognize the G domain of the laminin 5 alpha-subunit. (11580232)
2001
18
Treatment of ocular cicatricial pemphigoid with tacrolimus (FK 506). (11561793)
2001
19
A spontaneous canine model of mucous membrane (cicatricial) pemphigoid, an autoimmune blistering disease affecting mucosae and mucocutaneous junctions. (11437489)
2001
20
Tissue and molecular events in human conjunctival scarring in ocular cicatricial pemphigoid. (11642740)
2001
21
Management and outcome of cataract surgery in ocular cicatricial pemphigoid. (10766278)
2000
22
Remission of antiepiligrin (laminin-5) cicatricial pemphigoid after excision of gastric carcinoma. (10928780)
2000
23
The clinical and immunopathological manifestations of anti-epiligrin cicatricial pemphigoid, a recently defined subepithelial autoimmune blistering disease. (11125317)
2000
24
Cicatricial pemphigoid. (11004612)
2000
25
Non-specific scalp crusting as a presenting feature of Brunsting-Perry cicatricial pemphigoid. (10343952)
1999
26
Local interferon alfa-2b for ocular cicatricial pemphigoid. (8976708)
1996
27
Cicatricial pemphigoid with severe laryngeal involvement necessitating tracheostomy (laryngeal cicatricial pemphigoid). (8914362)
1996
28
Oesophageal webs associated with cicatricial pemphigoid. (8565261)
1995
29
Barium studies in esophageal cicatricial pemphigoid. (7787730)
1995
30
Inferior retractor plication surgery for lower lid entropion with trichiasis in ocular cicatricial pemphigoid. (8534641)
1995
31
Treatment of cicatricial pemphigoid with tetracycline and nicotinamide. (7671428)
1995
32
Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the alpha subunit of laminin 5. (7561156)
1995
33
Cryotherapy for trichiasis in ocular cicatricial pemphigoid. (7803353)
1994
34
Topical cyclosporine for cicatricial pemphigoid. (8425963)
1993
35
Serum levels of tumor necrosis factor-alpha and interleukin-6 in ocular cicatricial pemphigoid. (8258509)
1993
36
Alcaligenes faecalis corneal ulcer in a patient with cicatricial pemphigoid. (8430740)
1993
37
Cicatricial pemphigoid and carcinoma of the pancreas. (1330387)
1992
38
Two cases of cicatricial pemphigoid showing atypical immunofluorescent findings. (1776774)
1991
39
Cicatricial pemphigoid and erythema multiforme. (2199891)
1990
40
Bullous pemphigoid and cicatricial pemphigoid: immunoblotting detection of involved autoantigens. (2491598)
1989
41
Stenosis of left mainstem bronchus in a case of cicatricial pemphigoid. (3078423)
1988
42
Cicatricial pemphigoid in D-penicillamine treated patients with rheumatoid arthritis--a report of three cases. (3899425)
1985
43
Childhood cicatricial pemphigoid with linear IgA deposits. (6378448)
1984
44
Immunosuppressive therapy in ocular cicatricial pemphigoid. (6353928)
1983
45
Cicatricial pemphigoid confined to the larynx. (6988177)
1980
46
Bullous and cicatricial pemphigoid. Clinical, histopathologic, and immunopathologic correlations. (344998)
1977
47
Ocular cicatricial pemphigoid (immunologic studies). (798368)
1976
48
Immunologic aspects of cicatricial pemphigoid. (1090180)
1975
49
Circulating antibodies in cicatricial pemphigoid. (4579502)
1973
50
Pathogenesis of the blister in cicatricial pemphigoid and in bullous pemphigoid. A comparative ultrastructural study. (4584013)
1973

Genetic Variations for Cicatricial Pemphigoid

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Expression for genes affiliated with Cicatricial Pemphigoid

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cicatricial Pemphigoid

Search GEO for disease gene expression data for Cicatricial Pemphigoid.

Pathways for genes affiliated with Cicatricial Pemphigoid

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Sources:
29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 53Reactome
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Pathways related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HLA-DQB1
210.3HLA-DRB1
3
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10.2ITGA6, ITGB4
410.1IL4, IL5
510.0ITGA6, ITGB4, COL17A1
6
Hide members
9.9IL4, IL5, TNF
79.9TNF, IL5, IL4
89.9LAMC2, IL4, IL5
99.9TNF, IL4, TGFB1
10
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9.8IL5, CIITA, HLA-DRB1, HLA-DQB1
11
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9.8CSF1, CTGF, IL5, TGFB1
12
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9.8TNF, CD79A, IL5, IL4
13
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9.7IL5, CIITA, ITGA6, HLA-DRB1, HLA-DQB1
149.6LAMC2, IL4, ITGA6, ITGB4, CSF1
159.6COL17A1, ITGB4, ITGA6, DST, LAMC2
16
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9.6COL17A1, ITGB4, ITGA6, DST, LAMC2
179.6COL17A1, ITGB4, ITGA6, DST, LAMC2
18
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9.6IL4, CIITA, HLA-DRB1, HLA-DQB1, TNF
199.6TNF, HLA-DQB1, HLA-DRB1, CIITA, TGFB1
20
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9.5TNF, HLA-DQB1, HLA-DRB1, CD79A, IL4
21
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9.5COL17A1, ITGB4, ITGA6, PRG2, LAMC2
22
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9.5COL17A1, ITGB4, ITGA6, DST, LAMC2, SERPINH1
239.4CSF1, TNF, HLA-DRB1, ITGA6, IL5, IL4
24
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9.3COL17A1, CTGF, ITGB4, ITGA6, PRG2, LAMC2
25
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9.3CTGF, HLA-DQB1, HLA-DRB1, ITGB4, ITGA6, CD79A
26
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9.3TNF, CTGF, ITGB4, ITGA6, IL5, IL4
27
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9.2CSF1, CTGF, ITGB4, ITGA6, PRG2, IL5
28
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9.1CSF1, TNF, CTGF, ITGB4, ITGA6, IL5
29
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9.0TNF, HLA-DQB1, HLA-DRB1, CIITA, PRG2, RNASE3

Compounds for genes affiliated with Cicatricial Pemphigoid

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1pge24410.7TGFB1
2gm-csf44 2811.7TNF
3cycloheximide4410.5DST, COL17A1
4ivig4410.5CD79A, CSF1
5unicap4410.4CD79A, RNASE3, IL5
6indomethacin44 59 28 1113.3CSF1, PRG2, IL5
7beclomethasone dipropionate4410.3IL5, RNASE3, CSF1
8kalinin4410.2LAMC2, DST, ITGA6, ITGB4
9sodium cromoglycate4410.2CD79A, RNASE3, IL5
10nedocromil sodium4410.2CSF1, RNASE3, IL5, IL4
11praziquantel44 1111.2CD79A, RNASE3, IL5, IL4
12glatiramer acetate44 1111.2HLA-DRB1, CIITA, IL5, IL4
13salbutamol44 49 28 11 2414.2IL5, RNASE3, CD79A, CSF1
14cyclosporin a44 28 5912.2CTGF, CIITA, CD79A, RNASE3, SERPINH1
15pranlukast44 28 1112.2TNF, RNASE3, IL5, IL4
16h2o24410.1CTGF, MIF, CD79A
17ltc44410.1CSF1, PRG2, RNASE3, IL5
18methylcellulose4410.0CSF1, IL5, IL4, TGFB1
19polyinosinic-polycytidylic acid4410.0CSF1, TNF, CIITA, IL5, IL4
20anti-fungal4410.0IL5, RNASE3, CD79A, CSF1
21budesonide44 49 1112.0CSF1, TNF, RNASE3, IL5, IL4
22fluticasone propionate44 49 59 1113.0IL4, IL5, RNASE3, TNF, CSF1
23dexamethasone44 49 28 1113.0CTGF, CIITA, CD79A, RNASE3, IL5, TGFB1
24prednisolone44 28 1112.0CSF1, TNF, CD79A, RNASE3, IL5
25il 104410.0CSF1, TNF, IL5, IL4, TGFB1
26n-formylmethionyl-leucylphenylalanine449.9IL5, RNASE3, TNF, CSF1
27thyroxine44 2410.9CIITA, CD79A, IL5, IL4, TGFB1
28herbimycin a44 5910.9IL4, IL5, MIF, ITGA6, TNF
29rantes449.9CSF1, TNF, CIITA, RNASE3, IL4, TGFB1
30methacholine44 1110.8PRG2, CD79A, RNASE3, IL5, IL4, TGFB1
31methotrexate44 49 1111.8TNF, HLA-DRB1, ITGA6, CD79A, IL5, TGFB1
32carbamazepine44 49 1111.8IL4, IL5, CD79A, TNF
33n acetylcysteine449.8CSF1, TNF, CTGF, CD79A, RNASE3, IL4
34sb 20358044 5910.7TNF, CTGF, MIF, IL5, IL4, TGFB1
35allergens449.7IL4, IL5, RNASE3, CD79A, PRG2, CIITA
36paraffin449.7CSF1, DST, MIF, CD79A, IL5, IL4
37fmlp449.7CSF1, PRG2, RNASE3, IL5
38lactate449.6CSF1, TNF, CTGF, MIF, CD79A, RNASE3
39ly294002449.6TGFB1, IL4, IL5, CTGF, TNF, CSF1
40thymidine44 2410.5CSF1, TNF, CTGF, CIITA, MIF, IL5
41nitric oxide44 11 2411.5TNF, CTGF, ITGB4, CIITA, PRG2, MIF
42histamine44 28 2411.4CSF1, TNF, PRG2, CD79A, RNASE3, IL5
43actinomycin d449.4CSF1, TNF, CIITA, PRG2, IL4, TGFB1
44serine449.4COL17A1, CSF1, TNF, CTGF, ITGB4, CIITA
45tacrolimus44 49 1111.3TNF, CD79A, IL5, IL4, TGFB1
46oligonucleotide449.2ITGA6, HLA-DRB1, HLA-DQB1, CTGF, CIITA, PRG2
47vegf449.1CSF1, TNF, CTGF, ITGA6, MIF, CD79A
48cysteine449.1CTGF, CIITA, PRG2, MIF, CD79A, IL5
49retinoic acid44 2410.0CSF1, TNF, CTGF, ITGB4, ITGA6, PRG2
50tyrosine448.6COL17A1, CSF1, CTGF, HLA-DQB1, HLA-DRB1, ITGB4

GO Terms for genes affiliated with Cicatricial Pemphigoid

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Sources:
16Gene Ontology
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Cellular components related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal plasma membraneGO:00992510.1DST, ITGA6, ITGB4
2hemidesmosomeGO:03005610.0DST, ITGA6, ITGB4, COL17A1
3basement membraneGO:0056049.7COL17A1, ITGB4, ITGA6, DST, LAD1
4external side of plasma membraneGO:0098979.5TNF, HLA-DRB1, ITGA6, CD79A, IL4
5extracellular spaceGO:0056159.1CSF1, TNF, CTGF, MIF, IL5, IL4
6extracellular regionGO:0055768.4COL17A1, TNF, CTGF, PRG2, MIF, RNASE3

Biological processes related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.4IL4, CIITA
2positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.4MIF, TNF
3positive regulation of podosome assemblyGO:07180310.4TNF, IL5
4immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.4HLA-DQB1, HLA-DRB1
5positive regulation of B cell proliferationGO:03089010.3IL4, IL5, MIF
6integrin-mediated signaling pathwayGO:00722910.3CTGF, ITGB4, ITGA6, DST
7positive regulation of chemokine biosynthetic processGO:04508010.3TNF, IL4
8humoral immune response mediated by circulating immunoglobulinGO:00245510.2HLA-DQB1, HLA-DRB1
9positive regulation of MAP kinase activityGO:04340610.2TNF, MIF, TGFB1
10response to woundingGO:00961110.2CTGF, ITGB4, DST, TGFB1
11positive regulation of peptidyl-serine phosphorylationGO:03313810.2TGFB1, MIF, TNF
12interferon-gamma-mediated signaling pathwayGO:06033310.2CIITA, HLA-DRB1, HLA-DQB1
13cell-matrix adhesionGO:00716010.2COL17A1, CTGF, ITGB4, ITGA6
14negative regulation of gene expressionGO:01062910.2TNF, CTGF, MIF
15cell junction assemblyGO:03432910.1COL17A1, ITGB4, ITGA6, LAMC2
16cytokine-mediated signaling pathwayGO:01922110.1HLA-DQB1, HLA-DRB1, CIITA, IL5
17positive regulation of protein complex assemblyGO:03133410.1TGFB1, TNF
18positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.0IL4, IL5, TNF
19positive regulation of cellular protein metabolic processGO:03227010.0CSF1, TGFB1
20hemidesmosome assemblyGO:03158110.0LAMC2, DST, ITGA6, ITGB4, COL17A1
21inflammatory responseGO:0069549.9CSF1, TNF, MIF, IL5, TGFB1
22epidermis developmentGO:0085449.9COL17A1, CTGF, LAMC2
23positive regulation of protein phosphorylationGO:0019349.9TGFB1, CTGF, TNF
24positive regulation of transcription, DNA-dependentGO:0458939.8TNF, CIITA, IL5, IL4, TGFB1
25immune responseGO:0069559.7HLA-DQB1, HLA-DRB1, CIITA, PRG2, IL5, IL4
26positive regulation of ERK1 and ERK2 cascadeGO:0703749.6MIF, CTGF, TNF
27extracellular matrix organizationGO:0301989.5COL17A1, TNF, ITGB4, ITGA6, DST, LAMC2

Molecular functions related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.1HLA-DRB1, HLA-DQB1
2integrin bindingGO:0051789.7DST, ITGA6, CTGF
3growth factor activityGO:0080839.6TGFB1, IL4, IL5, CTGF, CSF1
4cytokine activityGO:0051259.5CSF1, TNF, MIF, IL5, IL4

Products for genes affiliated with Cicatricial Pemphigoid

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  • Antibodies
  • Proteins
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Sources for Cicatricial Pemphigoid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet