MCID: CCT002
MIFTS: 64

Cicatricial Pemphigoid malady

Eye diseases, Skin diseases categories

Summaries for Cicatricial Pemphigoid

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Cicatricial pemphigoid is a rare, chronic, blistering and scarring disease that affects the oral and ocular mucosa. other mucosal sites that might be affected include the nasopharnyx, larynx, genitalia, rectum, and esophagus. the condition usually begins in late adulthood (e.g. 50's or 60's), affects more women than men, and has a variable prognosis. scarring of the affected  mucosa of the eye may lead to blindness and tends to be the most feared complication. a combination of environmental and genetic factors appear to play a role in the susceptibility of developing benign mucosal pemphigoid. although the specific causes of benign mucosal pemphigoid have not been identified, the condition is considered an autoimmune disease that is characterized by the production of autoantibodies against basement membrane zone antigens such as bp180, bp230, and laminin 5.  treatment is dependent on the person's specific symptoms. last updated: 8/4/2009

MalaCards: Cicatricial Pemphigoid, also known as benign mucous membrane pemphigoid with ocular involvement, is related to bullous pemphigoid and epidermolysis bullosa. An important gene associated with Cicatricial Pemphigoid is ITGB4 (integrin, beta 4), and among its related pathways are HTLV-I infection and Cytokines and Inflammatory Response. The compounds pge2 and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are vision/eye and limbs/digits/tail.

Wikipedia:63 Cicatricial pemphigoid (also known as \"Mucous Membrane Pemphigoid\", \"MMP\", \"Benign mucosal... more...

Aliases & Classifications for Cicatricial Pemphigoid

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 48Orphanet, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Skin diseases


Aliases & Descriptions:

cicatricial pemphigoid 8 42 10
benign mucous membrane pemphigoid with ocular involvement 8 60
ocular pemphigoid 8 48
cicatricial pemphigoid with ocular involvement 8
benign mucous membrance pemphigoid 42
pemphigoid, benign mucous membrane 60
benign mucous membrane pemphigoid 8
benign mucosal pemphigoid 42
pemphigoid cicatricial 44
ocular pemphigus 8


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Disease Ontology8 DOID:11656
MeSH34 D010390
NCIt39 C34907
ICD9CM27 694.6
ICD10 via Orphanet26 H13.3*, L12+
ICD1025 H13.3, L12.1

Related Diseases for Cicatricial Pemphigoid

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17GeneCards, 18GeneDecks
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Diseases related to Cicatricial Pemphigoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1bullous pemphigoid31.3DST, ITGA6, COL17A1
2epidermolysis bullosa31.0LAMC2, DST, ITGA6, ITGB4, COL17A1
3epidermolysis bullosa acquisita30.9ITGB4, COL17A1, DST, CD79A, LAD1, LAMC2
4ocular cicatricial pemphigoid30.8CIITA, ITGA6, ITGB4
5rheumatoid arthritis30.8HLA-DRB1, CIITA
6arthritis30.8CSF1, TNF, CTGF, HLA-DRB1, CIITA, MIF
7pemphigus30.7CD79A, DST
8lichen planus30.6LAMC2, DST, COL17A1
9esophagitis30.6IL5, PRG2
10conjunctivitis30.5RNASE3, CD79A
11thyroiditis30.4CD79A, CIITA, HLA-DRB1
12periodontal disease30.4TNF, CD79A, LAMC2
13squamous cell carcinoma30.4COL17A1, ITGB4, ITGA6, DST, MIF, LAMC2
14lupus erythematosus30.4CD79A
15nephrotic syndrome30.1CD79A
16neutropenia30.1CSF1
17glaucoma30.1CTGF
18keratoconjunctivitis30.1IL5, RNASE3
19sjogren's syndrome30.1CD79A, CIITA
20dermatitis herpetiformis30.1HLA-DQB1, CD79A
21dermatitis30.1IL4, IL5, CD79A
22herpes gestationis30.1COL17A1, DST, RNASE3
23systemic lupus erythematosus30.1TNF, HLA-DQB1, HLA-DRB1, CIITA, MIF, CD79A
24gingivitis10.6
25laryngitis10.6
26periodontitis10.5
27stevens-johnson syndrome10.5
28cataract10.5
29cicatricial entropion10.4
30entropion10.4
31chronic conjunctivitis10.4
32mucous membrane pemphigoid10.4
33conjunctiva squamous cell carcinoma10.3
34sclerosing cholangitis10.3
35cholangitis10.3
36renal cell carcinoma10.3
37erythema multiforme10.3
38corneal ulcer10.3
39keratitis10.3
40brunsting-perry syndrome10.3
41munchausen by proxy10.1
42porphyria cutanea tarda10.1
43trachoma10.1
44mucoepidermoid carcinoma10.1
45alopecia10.1
46balanitis10.1
47gingival disease10.1
48herpes simplex10.1
49hodgkin's lymphoma10.1
50laryngeal carcinoma10.1

Graphical network of the top 20 diseases related to Cicatricial Pemphigoid:



Diseases related to cicatricial pemphigoid

Clinical Features for Cicatricial Pemphigoid

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Drugs & Therapeutics for Cicatricial Pemphigoid

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cicatricial Pemphigoid

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Anatomical Context for Cicatricial Pemphigoid

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32MalaCards
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MalaCards organs/tissues related to Cicatricial Pemphigoid:

32
Skin, Eye, Testes, Lung, Colon, Pancreas, T cells, Trachea

Animal Models for Cicatricial Pemphigoid or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cicatricial Pemphigoid:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.5DST, ITGB4
2MP:000537110.3CSF1, DST, SERPINH1
3MP:000536710.1HLA-DQB1, ITGB4, DST, LAMC2
4MP:00053899.9COL17A1, CSF1, DST, TGFB1
5MP:00107719.8COL17A1, CTGF, ITGB4, ITGA6, DST, TGFB1
6MP:00053959.8CSF1, ITGA6, DST, LAMC2
7MP:00036319.5CSF1, HLA-DQB1, ITGB4, ITGA6, DST, SERPINH1
8MP:00053779.5CSF1, CTGF, ITGB4, LAMC2
9MP:00053889.4TGFB1, CTGF, HLA-DQB1, ITGB4, ITGA6, PRG2
10MP:00053709.4TGFB1, IL4, IL5, HLA-DQB1, TNF, CSF1
11MP:00053799.4CSF1, TNF, ITGA6, CIITA, IL4, TGFB1
12MP:00053859.2CSF1, TNF, CTGF, HLA-DQB1, ITGB4, ITGA6
13MP:00053829.2CSF1, TNF, CTGF, ITGB4, ITGA6, IL4
14MP:00053818.9TNF, CTGF, HLA-DQB1, ITGB4, ITGA6, DST
15MP:00053848.9CSF1, TNF, CTGF, HLA-DQB1, ITGB4, ITGA6
16MP:00053788.8CTGF, TNF, CSF1, COL17A1, HLA-DQB1, ITGA6
17MP:00053768.8CSF1, TNF, CTGF, HLA-DQB1, ITGB4, CIITA
18MP:00053978.7CSF1, TNF, HLA-DQB1, ITGA6, CIITA, PRG2
19MP:00107688.5HLA-DQB1, CTGF, TNF, CSF1, COL17A1, ITGB4
20MP:00053878.3ITGA6, ITGB4, HLA-DQB1, TNF, CSF1, COL17A1

Publications for Cicatricial Pemphigoid

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50PubMed
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Articles related to Cicatricial Pemphigoid:

(show top 50)    (show all 425)
idTitleAuthorsYear
1
Hypopharyngeal presentation of cicatricial pemphigoid: videofluorographic and direct laryngoscopic findings. (23442384)
2013
2
Outcomes of cataract surgery in ocular cicatricial pemphigoid. (23941520)
2013
3
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. (23269857)
2012
4
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
5
Cicatricial pemphigoid vegetans. (17343590)
2007
6
Unrecognized cicatricial pemphigoid with oral manifestations and ocular complications. A case report. (18093453)
2007
7
Antiepiligrin cicatricial pemphigoid without mucous membrane involvement. (16225638)
2005
8
Ocular cicatricial pemphigoid: manifestations and management. (15967079)
2005
9
Topical tacrolimus treatment for cicatricial pemphigoid. (14726899)
2004
10
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
11
Usefulness of immunoblotting using purified laminin 5 in the diagnosis of anti-laminin 5 cicatricial pemphigoid. (14581137)
2003
12
Cicatricial pemphigoid differs from bullous pemphigoid and pemphigoid gestationis regarding the fine specificity of autoantibodies to the BP180 NC16A domain. (11916132)
2002
13
Role of enhanced expression of m-CSF in conjunctiva affected by cicatricial pemphigoid. (12202518)
2002
14
Identification of ocular cicatricial pemphigoid antibody binding site(s) in human beta4 integrin. (11157870)
2001
15
Anti-epiligrin cicatricial pemphigoid and relative risk for cancer. (11410196)
2001
16
Intravenous immunoglobulin therapy for ocular cicatricial pemphigoid: a preliminary study. (10571350)
1999
17
Drug-induced ocular cicatricial pemphigoid: a series of clinico-pathological reports. (9683956)
1998
18
HLA-DRB1 and HLA-DQB1 genes in susceptibility and resistance to cicatricial pemphigoid in French Caucasians. (9683867)
1998
19
Cicatricial pemphigoid (benign mucous membrane pemphigoid). (9759059)
1998
20
Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid. (9008223)
1997
21
Limbal conjunctival Langerhans cell density in ocular cicatricial pemphigoid: an indirect immunofluorescence study on Dispase-split conjunctiva. (9255511)
1997
22
Management of airway obstruction in cicatricial pemphigoid. (8699892)
1996
23
Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (8956662)
1996
24
Coexistence of pemphigus vulgaris and ocular cicatricial pemphigoid. (8621820)
1996
25
The immunological features and pathophysiology of ocular cicatricial pemphigoid. (7958021)
1994
26
Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid. (8052655)
1994
27
Cicatricial pemphigoid presenting as upper airways obstruction. (8179983)
1994
28
Retractor plication for lower lid entropion in ocular cicatricial pemphigoid. (8333940)
1993
29
Cicatricial pemphigoid. (8365035)
1993
30
Results of buccal mucosal grafting for patients with medically controlled ocular cicatricial pemphigoid. (1565450)
1992
31
Long-term results of systemic chemotherapy for ocular cicatricial pemphigoid. (1303858)
1992
32
Restriction of cicatricial pemphigoid antigens to the lamina densa: confirmation by indirect immunoelectron microscopy. (1401504)
1992
33
Association of autoimmunity and cicatricial pemphigoid: is there an immunogenetic basis? (1810979)
1991
34
Association of DQw7 (DQB1*0301) with ocular cicatricial pemphigoid. (1763074)
1991
35
Ocular cicatricial pemphigoid. (2202335)
1990
36
Studies of cicatricial pemphigoid autoantibodies using direct immunoelectron microscopy and immunoblot analysis. (2182720)
1990
37
Obstructive respiratory failure in cicatricial pemphigoid. (2672409)
1989
38
Sulphamethoxypyridazine for dermatitis herpetiformis, linear IgA disease and cicatricial pemphigoid. (2692691)
1989
39
Association of HLA-DR4 with ocular cicatricial pemphigoid. (2653736)
1989
40
The use of chemically split tissue in the detection of circulating anti-basement membrane zone antibodies in bullous pemphigoid and cicatricial pemphigoid. (3277659)
1988
41
Chronic bullous disease of childhood, childhood cicatricial pemphigoid, and linear IgA disease of adults. A comparative study demonstrating clinical and immunopathologic overlap. (3056993)
1988
42
Detection of ocular mucus in normal human conjunctiva and conjunctiva from patients with cicatricial pemphigoid using lectin probes and histochemical techniques. (3289955)
1988
43
Cicatricial pemphigoid: a case report. (3061861)
1988
44
The localization of the binding site of circulating IgA antibodies in linear IgA disease of adults, chronic bullous disease of childhood and childhood cicatricial pemphigoid. (3552019)
1987
45
Cicatricial pemphigoid in a patient with rheumatoid arthritis treated with D-penicillamine. (3514710)
1986
46
Disseminated cicatricial pemphigoid. (3908170)
1985
47
Benign mucous membrane (cicatricial) pemphigoid revisited: a clinical and immunological reappraisal. (6391523)
1984
48
Cicatricial pemphigoid (Brunsting-Perry type). Case report and immunofluorescence findings. (348119)
1978
49
Cicatricial pemphigoid. Immunofluorescent studies. (4212995)
1974
50
Fatal cicatricial mucous membrane pemphigoid of the trachea. (13885553)
1962

Genetic Variations for Cicatricial Pemphigoid

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Expression for genes affiliated with Cicatricial Pemphigoid

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cicatricial Pemphigoid

Search GEO for disease gene expression data for Cicatricial Pemphigoid.

Pathways for genes affiliated with Cicatricial Pemphigoid

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Sources:
29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 53Reactome
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Pathways related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HLA-DQB1
210.3HLA-DRB1
3
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10.2ITGA6, ITGB4
410.1IL4, IL5
510.0ITGA6, ITGB4, COL17A1
6
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9.9IL4, IL5, TNF
79.9TNF, IL5, IL4
89.9LAMC2, IL4, IL5
99.9TNF, IL4, TGFB1
10
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9.8IL5, CIITA, HLA-DRB1, HLA-DQB1
11
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9.8CSF1, CTGF, IL5, TGFB1
12
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9.8TNF, CD79A, IL5, IL4
13
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9.7IL5, CIITA, ITGA6, HLA-DRB1, HLA-DQB1
149.6LAMC2, IL4, ITGA6, ITGB4, CSF1
159.6COL17A1, ITGB4, ITGA6, DST, LAMC2
16
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9.6COL17A1, ITGB4, ITGA6, DST, LAMC2
179.6COL17A1, ITGB4, ITGA6, DST, LAMC2
18
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9.6IL4, CIITA, HLA-DRB1, HLA-DQB1, TNF
199.6TNF, HLA-DQB1, HLA-DRB1, CIITA, TGFB1
20
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9.5TNF, HLA-DQB1, HLA-DRB1, CD79A, IL4
21
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9.5COL17A1, ITGB4, ITGA6, PRG2, LAMC2
22
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9.5COL17A1, ITGB4, ITGA6, DST, LAMC2, SERPINH1
239.4CSF1, TNF, HLA-DRB1, ITGA6, IL5, IL4
24
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9.3COL17A1, CTGF, ITGB4, ITGA6, PRG2, LAMC2
25
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9.3CTGF, HLA-DQB1, HLA-DRB1, ITGB4, ITGA6, CD79A
26
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9.3TNF, CTGF, ITGB4, ITGA6, IL5, IL4
27
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9.2CSF1, CTGF, ITGB4, ITGA6, PRG2, IL5
28
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9.1CSF1, TNF, CTGF, ITGB4, ITGA6, IL5
29
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9.0TNF, HLA-DQB1, HLA-DRB1, CIITA, PRG2, RNASE3

Compounds for genes affiliated with Cicatricial Pemphigoid

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1pge24410.7TGFB1
2gm-csf44 2811.7TNF
3cycloheximide4410.5COL17A1, DST
4ivig4410.5CSF1, CD79A
5unicap4410.4IL5, CD79A, RNASE3
6indomethacin44 59 28 1113.3CSF1, IL5, PRG2
7beclomethasone dipropionate4410.3CSF1, RNASE3, IL5
8kalinin4410.2LAMC2, ITGB4, ITGA6, DST
9sodium cromoglycate4410.2RNASE3, CD79A, IL5
10nedocromil sodium4410.2IL4, IL5, RNASE3, CSF1
11praziquantel44 1111.2IL4, IL5, RNASE3, CD79A
12glatiramer acetate44 1111.2HLA-DRB1, CIITA, IL5, IL4
13salbutamol44 49 28 11 2414.2CSF1, CD79A, RNASE3, IL5
14cyclosporin a44 28 5912.2RNASE3, CD79A, CIITA, CTGF, SERPINH1
15pranlukast44 28 1112.2RNASE3, TNF, IL5, IL4
16h2o24410.1CTGF, MIF, CD79A
17ltc44410.1CSF1, IL5, RNASE3, PRG2
18methylcellulose4410.0TGFB1, IL4, IL5, CSF1
19polyinosinic-polycytidylic acid4410.0CSF1, TNF, CIITA, IL5, IL4
20anti-fungal4410.0CSF1, CD79A, RNASE3, IL5
21budesonide44 49 1112.0IL4, CSF1, TNF, IL5, RNASE3
22fluticasone propionate44 49 59 1113.0CSF1, IL5, IL4, RNASE3, TNF
23dexamethasone44 49 28 1113.0RNASE3, TGFB1, IL5, CD79A, CIITA, CTGF
24prednisolone44 28 1112.0CSF1, TNF, CD79A, RNASE3, IL5
25il 104410.0TNF, CSF1, IL5, TGFB1, IL4
26n-formylmethionyl-leucylphenylalanine449.9IL5, RNASE3, TNF, CSF1
27thyroxine44 2410.9CD79A, IL5, IL4, TGFB1, CIITA
28herbimycin a44 5910.9TNF, ITGA6, IL4, MIF, IL5
29rantes449.9CSF1, TNF, RNASE3, IL4, TGFB1, CIITA
30methacholine44 1110.8TGFB1, IL4, IL5, RNASE3, CD79A, PRG2
31methotrexate44 49 1111.8HLA-DRB1, TGFB1, CD79A, ITGA6, TNF, IL5
32carbamazepine44 49 1111.8IL5, CD79A, TNF, IL4
33n acetylcysteine449.8RNASE3, TNF, CD79A, CTGF, CSF1, IL4
34sb 20358044 5910.7CTGF, MIF, IL5, TNF, TGFB1, IL4
35allergens449.7CIITA, IL4, IL5, RNASE3, CD79A, PRG2
36paraffin449.7TGFB1, IL5, IL4, MIF, DST, CSF1
37fmlp449.7PRG2, CSF1, RNASE3, IL5
38lactate449.6RNASE3, TGFB1, MIF, CTGF, TNF, CSF1
39ly294002449.6CSF1, TNF, IL5, CTGF, IL4, TGFB1
40thymidine44 2410.5CSF1, CTGF, CIITA, MIF, IL5, TGFB1
41nitric oxide44 11 2411.5SERPINH1, TNF, ITGB4, CIITA, PRG2, MIF
42histamine44 28 2411.4CD79A, RNASE3, IL5, IL4, TGFB1, TNF
43actinomycin d449.4IL4, PRG2, CIITA, TNF, CSF1, TGFB1
44serine449.4CIITA, TNF, CSF1, COL17A1, MIF, TGFB1
45tacrolimus44 49 1111.3IL5, CD79A, TNF, IL4, TGFB1
46oligonucleotide449.2HLA-DQB1, HLA-DRB1, ITGA6, CTGF, CIITA, PRG2
47vegf449.1ITGA6, CTGF, TGFB1, SERPINH1, IL4, IL5
48cysteine449.1CTGF, IL4, IL5, CD79A, PRG2, CIITA
49retinoic acid44 2410.0CD79A, RNASE3, IL5, ITGA6, ITGB4, CTGF
50tyrosine448.6HLA-DRB1, COL17A1, CSF1, RNASE3, HLA-DQB1, MIF

GO Terms for genes affiliated with Cicatricial Pemphigoid

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Sources:
16Gene Ontology
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Cellular components related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal plasma membraneGO:00992510.1DST, ITGA6, ITGB4
2hemidesmosomeGO:03005610.0DST, ITGA6, ITGB4, COL17A1
3basement membraneGO:0056049.7COL17A1, ITGB4, ITGA6, DST, LAD1
4external side of plasma membraneGO:0098979.5TNF, HLA-DRB1, ITGA6, CD79A, IL4
5extracellular spaceGO:0056159.1CSF1, TNF, CTGF, MIF, IL5, IL4
6extracellular regionGO:0055768.4COL17A1, TNF, CTGF, PRG2, MIF, RNASE3

Biological processes related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.4IL4, CIITA
2positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.4MIF, TNF
3positive regulation of podosome assemblyGO:07180310.4TNF, IL5
4immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.4HLA-DQB1, HLA-DRB1
5positive regulation of B cell proliferationGO:03089010.3IL4, IL5, MIF
6integrin-mediated signaling pathwayGO:00722910.3CTGF, ITGB4, ITGA6, DST
7positive regulation of chemokine biosynthetic processGO:04508010.3TNF, IL4
8humoral immune response mediated by circulating immunoglobulinGO:00245510.2HLA-DQB1, HLA-DRB1
9positive regulation of MAP kinase activityGO:04340610.2TNF, MIF, TGFB1
10response to woundingGO:00961110.2CTGF, ITGB4, DST, TGFB1
11positive regulation of peptidyl-serine phosphorylationGO:03313810.2TGFB1, MIF, TNF
12interferon-gamma-mediated signaling pathwayGO:06033310.2CIITA, HLA-DRB1, HLA-DQB1
13cell-matrix adhesionGO:00716010.2COL17A1, CTGF, ITGB4, ITGA6
14negative regulation of gene expressionGO:01062910.2TNF, CTGF, MIF
15cell junction assemblyGO:03432910.1COL17A1, ITGB4, ITGA6, LAMC2
16cytokine-mediated signaling pathwayGO:01922110.1HLA-DQB1, HLA-DRB1, CIITA, IL5
17positive regulation of protein complex assemblyGO:03133410.1TGFB1, TNF
18positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.0IL4, IL5, TNF
19positive regulation of cellular protein metabolic processGO:03227010.0CSF1, TGFB1
20hemidesmosome assemblyGO:03158110.0LAMC2, DST, ITGA6, ITGB4, COL17A1
21inflammatory responseGO:0069549.9CSF1, TNF, MIF, IL5, TGFB1
22epidermis developmentGO:0085449.9COL17A1, CTGF, LAMC2
23positive regulation of protein phosphorylationGO:0019349.9TGFB1, CTGF, TNF
24positive regulation of transcription, DNA-dependentGO:0458939.8TNF, CIITA, IL5, IL4, TGFB1
25immune responseGO:0069559.7HLA-DQB1, HLA-DRB1, CIITA, PRG2, IL5, IL4
26positive regulation of ERK1 and ERK2 cascadeGO:0703749.6MIF, CTGF, TNF
27extracellular matrix organizationGO:0301989.5COL17A1, TNF, ITGB4, ITGA6, DST, LAMC2

Molecular functions related to Cicatricial Pemphigoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.1HLA-DRB1, HLA-DQB1
2integrin bindingGO:0051789.7DST, ITGA6, CTGF
3growth factor activityGO:0080839.6TGFB1, IL4, IL5, CTGF, CSF1
4cytokine activityGO:0051259.5CSF1, TNF, MIF, IL5, IL4

Products for genes affiliated with Cicatricial Pemphigoid

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  • Antibodies
  • Proteins
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Sources for Cicatricial Pemphigoid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet