MCID: CRR011
MIFTS: 24

Cirrhosis, Noncryptogenic malady

Summaries for Cirrhosis, Noncryptogenic

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46OMIM, 32MalaCards
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MalaCards: Cirrhosis, Noncryptogenic is related to pulmonary fibrosis and hepatoblastoma. An important gene associated with Cirrhosis, Noncryptogenic is KRT18 (keratin 18), and among its related pathways are Cytoskeletal Signaling and EGFR1 Signaling Pathway. The compounds griseofulvin and fitc have been mentioned in the context of this disorder.

Description from OMIM:46 215600

Aliases & Classifications for Cirrhosis, Noncryptogenic

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46OMIM
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Aliases & Descriptions:

cirrhosis, noncryptogenic 46


Related Diseases for Cirrhosis, Noncryptogenic

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cirrhosis, Noncryptogenic:



Diseases related to cirrhosis, noncryptogenic

Clinical Features for Cirrhosis, Noncryptogenic

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46OMIM
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Clinical features from OMIM:

215600

Drugs & Therapeutics for Cirrhosis, Noncryptogenic

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Cirrhosis, Noncryptogenic

Search CenterWatch for Cirrhosis, Noncryptogenic

Genetic Tests for Cirrhosis, Noncryptogenic

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Anatomical Context for Cirrhosis, Noncryptogenic

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Animal Models for Cirrhosis, Noncryptogenic or affiliated genes

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Publications for Cirrhosis, Noncryptogenic

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Genetic Variations for Cirrhosis, Noncryptogenic

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Cirrhosis, Noncryptogenic:

62
id Symbol AA change Variation ID SNP ID
1KRT18p.His128LeuVAR_003852rs57758506
2KRT18p.Thr103AlaVAR_023054rs61136606
3KRT18p.Arg261GlnVAR_023056
4KRT18p.Gly340ArgVAR_023057
5KRT8p.Gly53ValVAR_023058rs61710484
6KRT8p.Tyr54CysVAR_023059
7KRT8p.Gly62CysVAR_023060rs11554495

Expression for genes affiliated with Cirrhosis, Noncryptogenic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cirrhosis, Noncryptogenic

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Pathways for genes affiliated with Cirrhosis, Noncryptogenic

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Sources:
4Cell Signaling Technology, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Cirrhosis, Noncryptogenic according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1KRT8, KRT18
29.1KRT8, KRT18
39.1KRT8, KRT18

Compounds for genes affiliated with Cirrhosis, Noncryptogenic

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Cirrhosis, Noncryptogenic according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1griseofulvin44 1110.5KRT8, KRT18
2fitc449.5KRT8, KRT18
3diethyl dithiocarbamate449.5KRT18, KRT8
4hematoxylin449.5KRT8, KRT18
5n-acetylglucosamine449.5KRT8, KRT18
6urea44 11 2411.4KRT18, KRT8
7gold449.4KRT8, KRT18
8bromodeoxyuridine449.4KRT8, KRT18
9sucrose44 11 2411.4KRT18, KRT8
10agar449.4KRT8, KRT18
11retinoid449.4KRT8, KRT18
12matrigel449.4KRT18, KRT8
13butyrate449.4KRT8, KRT18
14ethanol44 49 11 2412.3KRT8, KRT18
15doxorubicin44 49 1111.3KRT18, KRT8
16glycogen44 2410.3KRT8, KRT18
17actinomycin d449.2KRT18, KRT8
18paraffin449.2KRT8, KRT18
19forskolin44 49 1111.1KRT8, KRT18
20creatinine449.1KRT8, KRT18
21iron44 2410.0KRT18, KRT8
22lactate448.8KRT8, KRT18

GO Terms for genes affiliated with Cirrhosis, Noncryptogenic

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16Gene Ontology
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Cellular components related to Cirrhosis, Noncryptogenic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1KRT8, KRT18
2keratin filamentGO:0450958.8KRT8, KRT18

Biological processes related to Cirrhosis, Noncryptogenic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:0190489.1KRT8, KRT18
2tumor necrosis factor-mediated signaling pathwayGO:0332098.8KRT8, KRT18

Molecular functions related to Cirrhosis, Noncryptogenic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.1KRT8, KRT18
2scaffold protein bindingGO:0971108.8KRT8, KRT18

Products for genes affiliated with Cirrhosis, Noncryptogenic

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cirrhosis, Noncryptogenic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet