MCID: CRR012
MIFTS: 22

Cirrhotic Cardiomyopathy

Categories: Cardiovascular diseases, Liver diseases, Rare diseases

Aliases & Classifications for Cirrhotic Cardiomyopathy

MalaCards integrated aliases for Cirrhotic Cardiomyopathy:

Name: Cirrhotic Cardiomyopathy 55

Characteristics:

Orphanet epidemiological data:

55
cirrhotic cardiomyopathy
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 55  
Rare hepatic diseases


External Ids:

Orphanet 55 ORPHA57777
ICD10 via Orphanet 33 I42.8

Summaries for Cirrhotic Cardiomyopathy

MalaCards based summary : Cirrhotic Cardiomyopathy is related to liver disease and hepatorenal syndrome. An important gene associated with Cirrhotic Cardiomyopathy is NPPA (Natriuretic Peptide A). The drugs Metoprolol and Dobutamine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and brain.

Related Diseases for Cirrhotic Cardiomyopathy

Diseases related to Cirrhotic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 liver disease 9.9
2 hepatorenal syndrome 9.9
3 hepatopulmonary syndrome 9.9
4 portal hypertension 9.7
5 peritonitis 9.7
6 fibrosis of extraocular muscles, congenital, 1 9.7
7 budd-chiari syndrome 9.7
8 liver cirrhosis 9.7

Graphical network of the top 20 diseases related to Cirrhotic Cardiomyopathy:



Diseases related to Cirrhotic Cardiomyopathy

Symptoms & Phenotypes for Cirrhotic Cardiomyopathy

Drugs & Therapeutics for Cirrhotic Cardiomyopathy

Drugs for Cirrhotic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metoprolol Approved, Investigational Phase 3 51384-51-1, 37350-58-6 4171
2
Dobutamine Approved Phase 3 34368-04-2 36811
3 Adrenergic Agents Phase 3
4 Adrenergic Agonists Phase 3
5 Adrenergic Antagonists Phase 3
6 Adrenergic beta-1 Receptor Antagonists Phase 3
7 Adrenergic beta-Agonists Phase 3
8 Adrenergic beta-Antagonists Phase 3
9 Sympatholytics Phase 3
10 Neurotransmitter Agents Phase 3
11 Peripheral Nervous System Agents Phase 3
12 Anti-Arrhythmia Agents Phase 3
13 Antihypertensive Agents Phase 3
14 Protective Agents Phase 3
15 Autonomic Agents Phase 3
16
Carvedilol Approved, Investigational 72956-09-3 2585
17 Liver Extracts
18 Adrenergic alpha-1 Receptor Antagonists
19 Adrenergic alpha-Antagonists
20 Vasodilator Agents
21 Antioxidants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 DOCICAR: Cardiac Dysfunction in Cirrhosis Completed NCT00250315 Phase 3 Dobutamine
2 Metoprolol Succinate in Cardiac Remodeling Related to Cirrhosis Completed NCT01676285 Phase 3 Metoprolol succinate;placebo
3 Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events Unknown status NCT01433848
4 Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity and Mortality Completed NCT02294292 Carvedilol;Ivabradine
5 Heart Rate Variability Change After Liver Transplantation Completed NCT00778687
6 Subclinical Myocardial Dysfunction in Patients With Hepatic Cirrhosis Completed NCT01713478
7 Hemodynamic Alterations in Liver Cirrhosis Validated by Non-invasive MR Compared to Invasive Assessment Recruiting NCT03443934

Search NIH Clinical Center for Cirrhotic Cardiomyopathy

Genetic Tests for Cirrhotic Cardiomyopathy

Anatomical Context for Cirrhotic Cardiomyopathy

MalaCards organs/tissues related to Cirrhotic Cardiomyopathy:

38
Liver, Heart, Brain

Publications for Cirrhotic Cardiomyopathy

Articles related to Cirrhotic Cardiomyopathy:

(show top 50) (show all 72)
# Title Authors Year
1
Cirrhotic cardiomyopathy is less prevalent in patients with Budd-Chiari syndrome than cirrhosis of liver. ( 29368192 )
2018
2
Cirrhotic cardiomyopathy: Implications for liver transplantation. ( 28407402 )
2017
3
Cirrhotic cardiomyopathy: is there any correlation between the stage of cardiac impairment and the severity of liver disease? ( 28245727 )
2017
4
Cirrhotic Cardiomyopathy: A New Clinical Phenotype. ( 28699978 )
2017
5
Minocycline attenuates cirrhotic cardiomyopathy and portal hypertension in a rat model: Possible involvement of nitric oxide pathway. ( 27917279 )
2016
6
Fragmented QRS is associated with cirrhotic cardiomyopathy in patients with decompensated cirrhosis. ( 27382936 )
2016
7
Cirrhotic cardiomyopathy: Isn't stress evaluation always required for the diagnosis? ( 26839643 )
2016
8
Impact and persistence of cirrhotic cardiomyopathy after liver transplantation. ( 27292629 )
2016
9
Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome. ( 27843430 )
2016
10
Prevalence of cirrhotic cardiomyopathy in patients with cirrhosis of liver. ( 27727569 )
2016
11
Galactin-3 and brain natriuretic peptide versus conventional echocardiography in the early detection of cirrhotic cardiomyopathy. ( 27458853 )
2016
12
The heart matters when the liver shatters! Cirrhotic cardiomyopathy: frequency, comparison, and correlation with severity of disease. ( 28053679 )
2016
13
Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy. ( 27217700 )
2016
14
Cirrhotic cardiomyopathy: Implications for the perioperative management of liver transplant patients. ( 25848474 )
2015
15
Anti-Apoptosis Effects on Hearts of SHSST Cyclodextrin Complex in a Carbon Tetrachloride-induced Cirrhotic Cardiomyopathy Rat Model. ( 25687490 )
2015
16
Prevalence and impact on survival of hepatopulmonary syndrome and cirrhotic cardiomyopathy in a cohort of cirrhotic patients. ( 25974637 )
2015
17
Cirrhotic cardiomyopathy. ( 26556983 )
2015
18
Hepatorenal syndrome with cirrhotic cardiomyopathy: case report and literature review. ( 25874140 )
2015
19
Cirrhotic cardiomyopathy in the pre- and post-liver transplantation phase. ( 26074443 )
2015
20
Assessment of cardiovascular physiology using dobutamine stress cardiovascular magnetic resonance reveals impaired contractile reserve in patients with cirrhotic cardiomyopathy. ( 26187817 )
2015
21
Cirrhotic cardiomyopathy: review of pathophysiology and treatment. ( 25221635 )
2014
22
Recent Advances in Cirrhotic Cardiomyopathy. ( 25404411 )
2014
23
Cirrhotic cardiomyopathy. ( 25870696 )
2014
24
Cirrhotic cardiomyopathy: A cardiologist's perspective. ( 25400434 )
2014
25
Cardiomyocyte apoptosis contributes to pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated mice. ( 24712830 )
2014
26
SHSST cyclodextrin complex prevents the fibrosis effect on CCla88-induced cirrhotic cardiomyopathy in rats through TGF-I^ pathway inhibition effects. ( 24815066 )
2014
27
Pathophysiological and clinical approach to cirrhotic cardiomyopathy. ( 25267959 )
2014
28
Opioid receptors blockade modulates apoptosis in a rat model of cirrhotic cardiomyopathy. ( 24971217 )
2014
29
Diastolic dysfunction characterizes cirrhotic cardiomyopathy. ( 25634400 )
2014
30
Cirrhotic cardiomyopathy and hepatopulmonary syndrome: prevalence and prognosis in a series of patients. ( 23615223 )
2013
31
Cirrhotic cardiomyopathy: pathogenesis and clinical relevance. ( 24217347 )
2013
32
Does cirrhotic cardiomyopathy exist? 50 years of uncertainty. ( 23995321 )
2013
33
New insights into cirrhotic cardiomyopathy. ( 23041091 )
2013
34
Frequency and severity of cirrhotic cardiomyopathy and its possible relationship with bacterial endotoxemia. ( 23907333 )
2013
35
Protective effects of erythropoietin on cirrhotic cardiomyopathy in rats. ( 22835858 )
2012
36
The heart: pathophysiology and clinical implications of cirrhotic cardiomyopathy. ( 23245476 )
2012
37
A perspective on cirrhotic cardiomyopathy. ( 21693251 )
2011
38
High brain-natriuretic peptide level predicts cirrhotic cardiomyopathy in liver transplant patients. ( 21276088 )
2011
39
The role of lipophilic bile acids in the development of cirrhotic cardiomyopathy. ( 20414815 )
2010
40
Perioperative considerations in patients with cirrhotic cardiomyopathy. ( 20124994 )
2010
41
Cirrhotic cardiomyopathy. ( 20688208 )
2010
42
Cirrhotic cardiomyopathy. ( 20462649 )
2010
43
Dobutamine stress echocardiography for evaluating cirrhotic cardiomyopathy in liver cirrhosis. ( 21415581 )
2010
44
Cirrhotic cardiomyopathy. ( 19669380 )
2009
45
Is the immediate reversal of diastolic dysfunction of cirrhotic cardiomyopathy after liver transplantation a sign of the metabolic etiology? ( 19877209 )
2009
46
Nuclear factor-kappaB inhibition improves myocardial contractility in rats with cirrhotic cardiomyopathy. ( 18346133 )
2008
47
Cirrhotic cardiomyopathy. ( 18293277 )
2008
48
Cirrhotic cardiomyopathy. ( 17389039 )
2007
49
Cirrhotic cardiomyopathy. ( 17383244 )
2007
50
Cirrhotic cardiomyopathy: multiple reviews. ( 17717858 )
2007

Variations for Cirrhotic Cardiomyopathy

Expression for Cirrhotic Cardiomyopathy

Search GEO for disease gene expression data for Cirrhotic Cardiomyopathy.

Pathways for Cirrhotic Cardiomyopathy

GO Terms for Cirrhotic Cardiomyopathy

Sources for Cirrhotic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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