HHV8
MCID: CLS007
MIFTS: 48

Classic Kaposi Sarcoma (HHV8) malady

Cancer diseases category

Summaries for Classic Kaposi Sarcoma

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MalaCards: Classic Kaposi Sarcoma, also known as human herpesvirus 8, is related to sarcoma and kaposi's sarcoma. An important gene associated with Classic Kaposi Sarcoma is HHV8S (Human herpesvirus 8, susceptibility to), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and TGF-Beta Pathway. The drugs etoposide and etoposide phosphate and the compounds hydrocortisone and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Classic Kaposi Sarcoma

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42NIH Rare Diseases, 46OMIM, 38NCBI Bookshelf, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

classic kaposi sarcoma 42
human herpesvirus 8 42 46
hhv8 42 38
kaposi sarcoma herpesvirus 42
classic kaposi's sarcoma 60
kaposi's sarcoma 42
kaposi sarcoma 60
kshv 42


Related Diseases for Classic Kaposi Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Classic Kaposi Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 294)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.5CD34, OSM
2kaposi's sarcoma30.5CD34, VEGFA, OSM, IFNA1, IFNA2
3mycosis fungoides30.4CXCR2, IFNA1, IFNA2
4poems syndrome30.4IL1B, VEGFA
5leukemia30.3IL1B, IL1A, IL4, CD34, B2M, OSM
6gingivitis30.2IL1B, IL1A
7hemangioma30.2CD34, VEGFA, IFNA2
8non-hodgkin lymphoma30.2FCGR3A, CD34, B2M, CCND1
9malaria30.2IL10, TNF
10tuberculosis30.2IL1B, IL4, IL10, CXCR2, TNF
11multiple myeloma30.2B2M, CCND1
12angiosarcoma30.2VWF, CD34
13hepatitis30.2IFNA1, IFNA2
14acquired immunodeficiency syndrome30.2IL1B, B2M, IFNA1
15peritonitis30.1IL1B, B2M, TNF
16hepatitis c30.1IL4, IL10, TNF, IFNA1, IFNA2
17systemic lupus erythematosus30.1FCGR3A, VWF, IL4, IL10, TNF, IFNA1
18pneumonia30.1IL1B, IL8, IL10, IL13, CXCR2, OSM
19myeloma30.1IL1B, IL4, CD34, VEGFA, B2M, OSM
20herpes zoster30.0FCGR3A
21paracoccidioidomycosis30.0IL10
22glomerulonephritis30.0IL1B, B2M
23dermatitis30.0IL1A, IL4, IL13
24arthritis30.0IL1B, IL1A, IL8, OSM, TNF
25synovitis30.0IL1B, IL1A, IL8, B2M, TNF
26atopic dermatitis30.0FCGR3A, IL1A, IL8, IL4, IL10, IL13
27ulcerative colitis30.0IL1B, IL1A, IL8, IL4, IL10, IL13
28rheumatoid arthritis30.0FCGR3A, IL1B, IL1A, IL8, IL4, IL10
29vasculitis29.9VWF, TNF, IFNA2
30liver cirrhosis29.9CD34, OSM, IFNA1, IFNA2
31hepatocellular carcinoma29.9CXCR2, CD34, VEGFA, IFNA1, IFNA2, CCND1
32diabetes mellitus29.9VWF, IL1B, VEGFA, B2M, TNF
33endemic kaposi sarcoma10.5
34primary pulmonary hypertension10.4
35hypertension10.4
36parapsoriasis10.3
37pemphigus10.3
38dementia10.3
39colon kaposi sarcoma10.3
40secondary syphilis10.3
41syphilis10.3
42cryptococcosis10.2
43lymphangioma10.2
44pulmonary tuberculosis10.2
45kshv inflammatory cytokine syndrome10.1
46bullous pemphigoid10.1
47pityriasis rosea10.1
48common variable immunodeficiency10.1
49anaplastic large cell lymphoma10.1
50granuloma annulare10.1

Graphical network of the top 20 diseases related to Classic Kaposi Sarcoma:



Diseases related to classic kaposi sarcoma

Clinical Features for Classic Kaposi Sarcoma

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Drugs & Therapeutics for Classic Kaposi Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Classic Kaposi Sarcoma

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Anatomical Context for Classic Kaposi Sarcoma

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Animal Models for Classic Kaposi Sarcoma or affiliated genes

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36MGI
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Publications for Classic Kaposi Sarcoma

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Genetic Variations for Classic Kaposi Sarcoma

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Expression for genes affiliated with Classic Kaposi Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Classic Kaposi Sarcoma

Search GEO for disease gene expression data for Classic Kaposi Sarcoma.

Pathways for genes affiliated with Classic Kaposi Sarcoma

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12EMD Millipore, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 59Tocris Bioscience, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Classic Kaposi Sarcoma according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.2IL1A
2
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10.0IL12A, IL13
3
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10.0IL4, IL1A
49.9IL1A, IL1B
59.7IFNA2, IFNA1
69.7IL8, IL4, IL13
79.6IL13, IL10, IL4
8
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9.6IL1B, IL1A, IL13
99.6IL13, IL1B, IL4
10
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9.6IL12A, IL13, IL1A, FCGR3A
119.5IL1A, IL1B, IL8
12
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9.5IL13, IL12A, OSM
139.5IL4, IL1B, IL8
14
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9.5OSM, IL12A, CCND1
15
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9.5IL12A, TNF, IL10
169.4IL1B, IL12A, TNF
17
Development Thrombopoetin signaling via JAK-STAT pathway
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9.4IL4, OSM, CCND1
18
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9.4TNF, IL8, IL4
19
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9.3IL1B, IL4, IL12A, B2M
20
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.3VEGFA, CCND1, OSM
21
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9.3IFNA1, TNF, IFNA2
22
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9.2IL12A, IL1B, IL1A, TNF
239.2FCGR3A, IL1B, IL1A, TNF
249.1TNF, IL12A, IL8, IL1B
259.1TNF, IL10, IL12A, IL1B
26
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9.1IL1B, IL10, TNF, IL12A
27
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9.1TNF, IL1A, IL8, IL1B
28
Immune response Bacterial infections in normal airways
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9.1IL1A, IL8, IL1B, TNF
299.0TNF, IL1A, IL12A, IL10, FCGR3A
309.0IFNA1, TNF, IL8, IFNA2
31
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8.9IL1A, IL4, TNF, CCND1, IL1B
328.9TNF, IL1A, IL1B, CCND1, IL4
33
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8.8IFNA1, IL1B, IFNA2, B2M, IL1A
348.8CCND1, IL10, TNF, IL1B, IL1A
358.8IL1B, IL10, IL12A, TNF, IL8
368.8B2M, IL10, IL4, CD34
37
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8.6IL1B, IL8, TNF, IFNA1, IFNA2
388.5IL1A, IL12A, TNF, IL1B, IL10, IL8
398.3IL1A, IL1B, TNF, IL4, CD34
40
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8.2IL13, FCGR3A, IFNA2, IFNA1, TNF, VEGFA
41
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8.1IFNA1, OSM, CXCR2, IL13, IL1A, IL12A
428.1IL1A, IL8, IL10, VEGFA, TNF, IL13
438.0CCND1, IFNA2, IFNA1, OSM, VEGFA, IL4
447.9IL13, IFNA1, IFNA2, IL10, IL12A, OSM
45
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7.8IL1A, IFNA2, IFNA1, STIM1, B2M, CD34
46
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7.8IL8, IL12A, IL10, TNF, IFNA1, IL1B
47
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7.4IL13, IL12A, IL4, IL8, TNF, IFNA1
487.3IL10, IL12A, IL4, IL8, IL1A, IL1B
49
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7.3IL1B, OSM, TNF, CCND1, IL10, IL12A
50
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7.1IL13, IL10, CCND1, IFNA2, IFNA1, B2M

Compounds for genes affiliated with Classic Kaposi Sarcoma

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44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Classic Kaposi Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.5IL8
2pge24410.5VEGFA
3cycloheximide4410.4IFNA1
4pentoxifylline44 1111.4IL4, IL13
5indomethacin44 59 28 1113.3OSM
6ivig4410.1VWF, FCGR3A, IL1A
7lamivudine44 1111.1IL4, B2M
8gm-csf44 2811.1TNF, IL10
9cyclosporin a44 28 5912.0B2M, IFNA1
10endotoxin449.7OSM, CXCR2
11fmlp449.4CXCR2, FCGR3A, IL13, IL1A
12cyclophosphamide44 49 1111.4B2M, IFNA1, VWF, IFNA2
13dexamethasone44 49 28 1112.2IL13, VEGFA, OSM, IFNA1
14budesonide44 49 1111.0IL13, IL4, IL8, TNF, IL1B
15tarc448.9IL10, IL13, TNF, IL8, IL1A, IL4
16mip 1alpha448.9IL8, IL1B, IL10, IL4, IL13, TNF
17prednisolone44 28 1110.9IFNA1, VWF, IL13, IFNA2
18etanercept44 49 1110.9IFNA2, TNF, IL8, IL1B, FCGR3A, IL10
19fluticasone propionate44 49 59 1111.9IL4, IL8, IL1B, TNF, IL13
20polymyxin b448.9IL4, TNF, IL10, IL1B, IL8, IL1A
21imiquimod44 28 59 1111.8IL1A, IFNA2, TNF, IL10, IL8, IFNA1
22ns 39844 599.8VEGFA, IL8, IL1A, CCND1, TNF, IL1B
23infliximab44 49 1110.7IL1B, IL4, IL10, VEGFA, TNF, IFNA2
24il 10448.7TNF, IL13, IL10, IL4, IL8, IL1A
252,5-oligoadenylate448.7IFNA2, TNF, IL10, IFNA1, B2M
26poly(i-c)448.5IL8, IFNA1, TNF, IL4, IL1B
27rantes448.5IL4, OSM, IL1A, TNF, IL1B, IFNA1
28calcitriol44 59 11 2411.5TNF, IL1B, IL1A, IL4, IL10, IL13
29lipoteichoic acid448.5TNF, IL1B, IL8, CXCR2, IL10
3015-deoxy-delta-12,14-prostaglandin j2448.5IL8, IL4, IL1B, IL10, VEGFA, TNF
31simvastatin44 49 59 28 11 2413.4IL4, VWF, IL1A, IL8, VEGFA, TNF
32il-12448.4IL13, TNF, IL1B, IFNA1, IL8, IL4
33ccl344 289.4IL8, IFNA1, IL13, IL10, IL1B, TNF
34polyinosinic-polycytidylic acid448.4IL4, TNF, IFNA1, IL1A, IL1B, IL8
35rituximab44 49 1110.3B2M, TNF, IFNA1, IFNA2, IL13, VWF
36leukotriene b444 59 2410.3IL8, IL13, CXCR2, TNF, IL1A, IL1B
37thymidylate448.3IFNA1, IFNA2, CCND1, B2M, VEGFA, IL10
38groalpha448.3IL13, IL1B, IL10, CXCR2, TNF, IL8
39hyaluronic acid44 249.2OSM, IL1B, IL1A, IL8, VEGFA, B2M
40ly294002448.1IL4, IL10, IL13, VEGFA, TNF, CCND1
41sb 20358044 599.0IL4, IL10, IL1B, CCND1, TNF, VEGFA
42neopterin447.9IFNA2, IL1A, IFNA1, TNF, B2M, IL10
43actinomycin d447.9IL1A, IFNA1, IL1B, IL8, IL4, IL13
44herbimycin a44 598.9TNF, OSM, CXCR2, IL1A, IL8, FCGR3A
45histamine44 28 249.8IL10, IL4, IL8, IL1B, VWF, IFNA2
46thalidomide44 49 59 1110.6IL1A, IL1B, IL10, IL13, VEGFA, B2M
47genistein44 28 59 2 11 2412.3IL1B, IL1A, IL8, CXCR2, VEGFA, B2M
48thymidine44 247.4CCND1, IFNA2, TNF, OSM, B2M, CD34
49retinoic acid44 247.0IFNA2, CXCR2, CD34, B2M, OSM, TNF
50vegf444.7CCND1, VWF, IL1B, IL1A, IFNA2, IFNA1

GO Terms for genes affiliated with Classic Kaposi Sarcoma

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16Gene Ontology
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Cellular components related to Classic Kaposi Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098977.6FCGR3A, VWF, IL4, IL13, CD34, B2M
2extracellular regionGO:0055767.4VWF, IL1B, IL1A, IL8, IL13, VEGFA
3extracellular spaceGO:0056156.5IL12A, IL13, IL10, B2M, IL4, IL8

Biological processes related to Classic Kaposi Sarcoma according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.2IL1B, IL1A
2regulation of isotype switchingGO:04519110.2IL4, IL10
3regulation of proton transportGO:01015510.2IL13, IL4
4type 2 immune responseGO:04209210.1IL4, IL10
5positive regulation of MHC class II biosynthetic processGO:04534810.0IL4, IL10
6receptor biosynthetic processGO:03280010.0IL10, TNF
7positive regulation of calcidiol 1-monooxygenase activityGO:06055910.0TNF, IL1B
8sequestering of triglycerideGO:03073010.0IL1B, TNF
9response to molecule of bacterial originGO:0022379.9IL8, B2M, IL10
10positive regulation of heterotypic cell-cell adhesionGO:0341169.9IL1B, TNF
11negative regulation of cytokine secretion involved in immune responseGO:0027409.9IL10, TNF
12positive regulation of T cell proliferationGO:0421029.9IL4, IL12A, IL1B
13positive regulation of fever generationGO:0316229.9TNF, IL1B
14positive regulation of cytokine secretionGO:0507159.8TNF, IL10, IL1A
15positive regulation of interferon-gamma productionGO:0327299.8TNF, IL12A, IL1B
16positive regulation of chemokine biosynthetic processGO:0450809.8IL1B, IL4, TNF
17negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8TNF, IL1A, IL1B
18positive regulation of mitosisGO:0458409.8IL1B, TNF, IL1A
19regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.6TNF, IL1B
20response to ethanolGO:0454719.6CCND1, IL4, IL13
21neutrophil chemotaxisGO:0305939.5IL8, CXCR2, IL1B
22cytokine-mediated signaling pathwayGO:0192219.5IL1A, IL1B, B2M, IFNA2
23negative regulation of nitric oxide biosynthetic processGO:0450199.4IL10, IL4, CD34
24positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL4, IL1B, IL10, TNF
25positive regulation of protein phosphorylationGO:0019349.4CCND1, TNF, VEGFA, IL1B
26positive regulation of cell divisionGO:0517819.3IL1B, IL1A, VEGFA, OSM
27cell-cell signalingGO:0072679.3IL10, IFNA2, IL13, IL1B
28regulation of immune responseGO:0507769.3B2M, FCGR3A, CD34, IL4
29positive regulation of peptidyl-serine phosphorylationGO:0331389.3VEGFA, OSM, TNF
30response to drugGO:0424939.2IL4, B2M, IL10, CCND1, TNF
31neutrophil activationGO:0421199.2IL8, CXCR2
32negative regulation of gene expressionGO:0106299.0CD34, TNF, IFNA2
33positive regulation of angiogenesisGO:0457669.0VEGFA, CD34, IL1A, IL1B
34negative regulation of cell proliferationGO:0082858.9IL1B, OSM, TNF, IL8, IL1A
35immune responseGO:0069558.5OSM, FCGR3A, IL1B, IL1A, IL8, IL4
36apoptotic processGO:0069158.3CXCR2, TNF, IL1B, IL1A, OSM, IFNA2
37positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IL1B, IL1A, IL4, IL10, VEGFA, OSM
38inflammatory responseGO:0069548.1TNF, IL1B, IL1A, IL8, IL10, IL13

Molecular functions related to Classic Kaposi Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.8VWF, VEGFA, B2M, STIM1, TNF
2growth factor activityGO:0080838.6IL4, IL12A, IL10, VEGFA, OSM
3cytokine activityGO:0051257.2IL1B, IFNA2, TNF, OSM, VEGFA, IL13
4protein bindingGO:0055156.2CCND1, IFNA2, TNF, STIM1, B2M, VWF

Products for genes affiliated with Classic Kaposi Sarcoma

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Sources for Classic Kaposi Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet