MCID: CLR003
MIFTS: 60

Clear Cell Adenocarcinoma malady

Cancer diseases category

Summaries for Clear Cell Adenocarcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Clear-cell adenocarcinoma is a type of adenocarcinoma. more...

MalaCards: Clear Cell Adenocarcinoma, also known as water-clear cell adenocarcinoma, is related to adenocarcinoma and endometriosis. An important gene associated with Clear Cell Adenocarcinoma is HNF1B (HNF1 homeobox B), and among its related pathways are Axon guidance and Remodeling of Adherens Junctions. The compounds glutamate and leptomycin b have been mentioned in the context of this disorder. Affiliated tissues include cervix, ovary and colon, and related mouse phenotypes are reproductive system and integument.

Disease Ontology:8 An adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

Aliases & Classifications for Clear Cell Adenocarcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

clear cell adenocarcinoma 8 10
water-clear cell adenocarcinoma 8 60
mesonephroid clear cell carcinoma 8
clear cell adenocarcinoma nos 8
adenocarcinoma, clear cell 60
water-clear cell carcinoma 8
adenocarcinoma clear cell 44
mesonephroma, malignant 8
malignant mesonephroma 8
wolffian duct neoplasm 8
mesonephric tumor 60
mesonephroma nos 8
mesonephroma 8


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Disease Ontology8 DOID:4468
NCIt39 C4072
MeSH34 D008649

Related Diseases for Clear Cell Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.0SMAD4, STS, PIK3CA, WT1, HNF1B, STMN1
2endometriosis31.1HNF1B, STS, MUC16, AHR, ESR2
3colon adenocarcinoma30.8AHR, ESR2, SMAD4
4cervical adenocarcinoma30.7MUC16
5adenoma30.7MET, AHR, INHBA, GPX3, ESR2, SMAD4
6ovarian cancer30.6SMAD4, SMAD2, ESR2, MUC16, AFP, MET
7peritonitis30.5MUC16
8rhabdomyosarcoma30.3SMAD4, SMAD2, MET, WT1
9lung adenocarcinoma30.3PIK3CA, STMN1, MET, MUC16, AHR, ESR2
10squamous cell carcinoma30.3ANXA4, MET, STMN1, PIK3CA, MUC16, AHR
11endometrial carcinoma30.1WT1, MUC16, ESR2
12gastric adenocarcinoma30.1PIK3CA, MET, AFP, MUC16, SMAD4
13ovarian cyst30.1ESR2, MUC16
14ovarian clear cell adenocarcinoma11.1
15urethra clear cell adenocarcinoma10.8
16ovary adenocarcinoma10.8
17vaginitis10.8
18urethra adenocarcinoma10.8
19bladder clear cell adenocarcinoma10.8
20bladder adenocarcinoma10.7
21endometrial clear cell adenocarcinoma10.7
22urethritis10.6
23endometrial adenocarcinoma10.6
24cervical clear cell adenocarcinoma10.6
25urethral diverticulum10.5
26cervicitis10.5
27clear cell adenoma10.5
28nephrogenic adenoma10.4
29fallopian tube clear cell adenocarcinoma10.4
30ovarian endometriosis10.4
31clear cell adenofibroma10.4
32adenofibroma10.4
33prostate adenocarcinoma10.4
34prostatitis10.4
35bile duct clear cell adenocarcinoma10.3
36renal clear cell carcinoma10.3
37bladder diffuse clear cell adenocarcinoma10.3
38bladder tubulo-cystic clear cell adenocarcinoma10.3
39bladder papillary clear cell adenocarcinoma10.3
40uterine ligament clear cell adenocarcinoma10.3
41ampulla of vater clear cell adenocarcinoma10.3
42mucinous adenocarcinoma10.3
43cell type cancer10.3
44papillary adenocarcinoma10.3
45endometriosis of ovary10.2
46ovary rhabdomyosarcoma10.2
47nephrogenic adenoma of the urethra10.2
48hypercalcemia10.2
49ureter adenocarcinoma10.2
50renal pelvis adenocarcinoma10.2

Graphical network of the top 20 diseases related to Clear Cell Adenocarcinoma:



Diseases related to clear cell adenocarcinoma

Clinical Features for Clear Cell Adenocarcinoma

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Drugs & Therapeutics for Clear Cell Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Clear Cell Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Clear Cell Adenocarcinoma

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Genetic Tests for Clear Cell Adenocarcinoma

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Anatomical Context for Clear Cell Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Clear Cell Adenocarcinoma:

32
Cervix, Ovary, Colon, Prostate, Uterus, Kidney, Lung, Tongue, Salivary gland, Brain, Lymph node, Pancreas, Smooth muscle, Testis, Spleen, Endothelial

Animal Models for Clear Cell Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Clear Cell Adenocarcinoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.3WT1, PIK3CA, NEU4, AFP, SMAD2, SMAD4
2MP:001077110.3PIK3CA, AHR, SMAD2, SMAD4
3MP:000363110.3ESR2, GPX3, TUBB3
4MP:000538810.2TUBB3, MET, AHR, PTHLH, ESR2, SMAD2
5MP:000200610.2PIK3CA, MET, AFP, AHR, ESR2, SMAD2
6MP:000537910.2HNF1B, WT1, PIK3CA, AFP, AHR, INHBA
7MP:000536910.2HNF1B, WT1, STMN1, MET, AHR, INHBA
8MP:000537010.2HNF1B, WT1, MET, AHR, ESR2, SMAD2
9MP:000537610.2HNF1B, PIK3CA, STMN1, NEU4, AFP, INHBA
10MP:000538110.1MET, AHR, INHBA, PTHLH, ESR2, SMAD2
11MP:000287310.1WT1, STMN1, MET, MAP4, INHBA, ESR2
12MP:000538710.0MET, PIK3CA, WT1, HNF1B, AHR, ACTN4
13MP:000301210.0PIK3CA, MET, AHR, ESR2, SMAD2, WT1
14MP:000536710.0SMAD4, HNF1B, WT1, MET, ANXA4, AHR
15MP:000538510.0WT1, PIK3CA, STMN1, MET, AHR, GPX3
16MP:000538610.0PIK3CA, MET, NEU4, AFP, ANXA4, INHBA
17MP:00053849.9TUBB3, WT1, PIK3CA, MET, NEU4, ACTN4
18MP:00053809.9HNF1B, WT1, PIK3CA, MET, INHBA, SMAD2
19MP:00053789.9HNF1B, WT1, PIK3CA, MET, NEU4, AHR
20MP:00107689.7NEU4, MET, PIK3CA, WT1, TUBB3, HNF1B
21MP:00053979.6WT1, AHR, INHBA, GPX3, PTHLH, ESR2

Publications for Clear Cell Adenocarcinoma

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50PubMed
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Articles related to Clear Cell Adenocarcinoma:

(show top 50)    (show all 379)
idTitleAuthorsYear
1
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent. (23849091)
2014
2
Clear cell adenocarcinoma of the ovary with a sarcoid reaction in the spleen and regional lymph nodes: A case report. (24371694)
2013
3
Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells. (24244679)
2013
4
Vaginal laparoscopically assisted radical trachelectomy in cervical clear cell adenocarcinoma. (24244219)
2013
5
A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry. (22615710)
2012
6
Mixed angiosarcoma, clear cell adenocarcinoma and mature teratoma elements in an ovarian tumor: a case report and literature review. (22827762)
2012
7
Re-expression of estrogen receptor I^ inhibits the proliferation and migration of ovarian clear cell adenocarcinoma cells. (21874257)
2011
8
Immunohistochemical evidence for the over-expression of Glutathione peroxidase 3 in clear cell type ovarian adenocarcinoma. (20730571)
2011
9
Endometrial clear cell adenocarcinoma diagnosed by endometrial cytological examination: two cases report. (21319323)
2011
10
Epithelioid clear cell smooth muscle tumor of the ovary presenting as a mural nodule in an endometrioid adenocarcinoma with clear cell changes. (21131832)
2011
11
Primary clear cell adenocarcinoma of the rectum: a case report. (20405292)
2010
12
Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas. (20134266)
2010
13
Clear cell adenocarcinoma of the urinary bladder: a short review. (19492895)
2009
14
PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas. (19007975)
2009
15
Clear cell adenocarcinoma cervix: a diagnostic dilemma. (19332946)
2009
16
Clear cell adenocarcinoma of a female urethra: A case report and review of the literature. (22666717)
2009
17
A synthetic retinoid, TAC-101 (4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid), plus cisplatin: potential new therapy for ovarian clear cell adenocarcinoma. (18048092)
2008
18
Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: case report with molecular analysis. (19030216)
2008
19
Clear-cell adenocarcinoma of the uterine cervix in a 17-year-old adolescent. (19093185)
2008
20
Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics. (17592265)
2007
21
Persistent and moderate hypercalcemia related to an ovarian clear cell adenocarcinoma: Pre- and postoperative parathyroid hormone related-peptide and 1,25-dihydroxyvitamin D3 levels. (16794368)
2006
22
Clear-cell adenocarcinoma of the female genital tract: presence of hyaline stroma and tigroid background in various types of cytologic specimens. (15880717)
2005
23
WT1 and WT1-AS genes are inactivated by promoter methylation in ovarian clear cell adenocarcinoma. (16134181)
2005
24
Clear cell adenocarcinoma of the tunica vaginalis of the testis with an adjacent uterus-like tissue. (15260857)
2004
25
Clear cell adenocarcinoma of the maxillary sinus: a case report. (15027741)
2003
26
Clear cell adenocarcinoma within a tamoxifen-related polyp. (12366493)
2002
27
Steroid sulfatase expression in ovarian clear cell adenocarcinoma: immunohistochemical study. (11520136)
2001
28
Concurrent primaries of vaginal clear cell adenocarcinoma and endometrial adenocarcinoma in a 39-year old woman with in utero diethylstilbestrol exposure. (11437935)
2001
29
Multicentric clear cell adenocarcinoma in the urinary bladder and the urethral diverticulum: evidence of origin of clear cell adenocarcinoma of the female lower urinary tract from MA1llerian duct remnants. (10841652)
2000
30
Parotid metastasis from renal clear cell adenocarcinoma. An unusual site for metastasis. (9933847)
1998
31
Vesical clear cell adenocarcinoma. V. Nephrogenic adenoma: a diagnostic problem. (7557905)
1995
32
Clear cell adenocarcinoma of the vagina in a young female, treated by combination chemotherapy (local and systemic chemotherapy), complicated with chromosomal abnormality. (7959294)
1994
33
Conservative surgery plus adjuvant therapy for vulvovaginal rhabdomyosarcoma, diethylstilbestrol clear cell adenocarcinoma of the vagina, and unilateral germ cell tumors of the ovary. (1316595)
1992
34
Clear cell adenocarcinoma of the lower genital tract. Correlation of mother's recall of diethylstilbestrol history with obstetrical records. (2224777)
1990
35
Clear cell adenocarcinoma of the female urethra. A case report. (3389150)
1988
36
Solitary cyst and clear cell adenocarcinoma of the kidney: report of 2 cases and review of the literature. (3735516)
1986
37
Nephrogenic adenoma. A report of 15 cases, review of the literature, and comparison with clear cell adenocarcinoma of the urinary tract. (3706613)
1986
38
Colposcopic and pathologic features in two cases of DES-related vaginal clear-cell adenocarcinoma. (6834354)
1983
39
Mucinous adenocarcinoma and clear cell adenocarcinoma arising in separate ovaries. (6293404)
1983
40
DES-related clear cell adenocarcinoma of the vagina in pregnancy. (7243130)
1981
41
Clear cell adenocarcinoma of the urethra. A case report. (7323759)
1981
42
An analysis of 346 cases of clear cell adenocarcinoma of the vagina and cervix with emphasis on recurrence and survival. (437563)
1979
43
The DES syndrome and clear cell adenocarcinoma in young women. (248302)
1978
44
Intrauterine diethylstilbestrol exposure and its consequences: pathologic characteristics of vaginal adenosis, clear cell adenocarcinoma, and related lesions. (576195)
1977
45
Clear-cell adenocarcinoma of the cervix in young women. (4473263)
1974
46
Clear-cell adenocarcinoma of the female genital tract. A light and electron microscopic study. (4819225)
1974
47
Clear-cell adenocarcinoma of the vagina. Reconstruction after radical surgery. (4615356)
1974
48
Clear-cell adenocarcinoma of the cervix after maternal treatment with synthetic estrogens. (5073941)
1972
49
Encapsulation of clear cell adenocarcinoma of the kidney by fibrotic tissue. (5114045)
1971
50
Papillary clear cell adenocarcinoma of the ovary. (18137078)
1949

Genetic Variations for Clear Cell Adenocarcinoma

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Expression for genes affiliated with Clear Cell Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Clear Cell Adenocarcinoma.

Pathways for genes affiliated with Clear Cell Adenocarcinoma

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 12EMD Millipore
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Compounds for genes affiliated with Clear Cell Adenocarcinoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1glutamate4410.7MAP4, AHR
2leptomycin b44 5911.6SMAD4, SMAD2, PTHLH, AHR
3progestin4410.6PTHLH, ESR2, AHR, STS
4b 7234410.6WT1, AFP, MUC16
5crcs4410.5SMAD4, PIK3CA, MET
6dihydrotestosterone44 28 11 2413.5STS, PTHLH, ESR2, SMAD2, SMAD4
7nocodazole44 1111.5MAP4, STMN1, PTHLH, SMAD2
8estrone44 28 11 2413.5ESR2, AHR, AFP, STS
9agar4410.5PIK3CA, MET, PTHLH, SMAD4, AFP
10dmso4410.5ESR2, AHR, PIK3CA, AFP, TUBB3
11arsenite44 2411.5PIK3CA, STS, AHR
12tgf beta14410.5SMAD2, AFP, PTHLH, SMAD4
13vitamin d4410.5AHR, PTHLH, ESR2, AFP, MET, WT1
14tamoxifen44 49 28 1113.4PIK3CA, STS, AHR, PTHLH, ESR2
15paclitaxel44 49 1112.4AFP, MAP4, MUC16, STMN1, TUBB3, PIK3CA
16pd 98,0594410.4MET, SMAD2, PIK3CA, STMN1, SMAD4
17actinomycin d4410.4MET, AFP, AHR, PTHLH, ESR2, PIK3CA
18dexamethasone44 49 28 1113.4SMAD2, AHR, PIK3CA, AFP, MUC16, GPX3
19thyroxine44 2411.4AHR, GPX3, PTHLH, AFP
20creatinine4410.4MUC16, PTHLH, GPX3, AFP, STMN1, WT1
21cisplatin44 49 59 1113.4TUBB3, MUC16, PTHLH, AFP, MET, STMN1
22h2o24410.4AFP, MUC16, ESR2, SMAD2, PIK3CA
23paraffin4410.4SMAD4, WT1, MET, AFP, PTHLH, ESR2
24heparin44 28 11 2413.4PTHLH, PIK3CA, MET, ANXA4, AFP, GPX3
25thymidine44 2411.4SMAD4, PTHLH, AFP, WT1, SMAD2, MET
26steroid4410.3PTHLH, AHR, MUC16, AFP, STS, PIK3CA
27ccl444 2811.3AFP, MET, PTHLH
28kaempferol4410.3AHR, ESR2
29nitric oxide44 11 2412.3SMAD4, TUBB3, WT1, SMAD2, PIK3CA, MET
30glucose4410.3GPX3, SMAD2, SMAD4, HNF1B, PTHLH, MUC16
31oligonucleotide4410.3STMN1, SMAD2, INHBA, AFP, MET, WT1
32estradiol44 11 2412.3AFP, PTHLH, ESR2, STS, MUC16, AHR
33cholesterol44 28 11 2413.3AFP, GPX3, MET, STS, PIK3CA, HNF1B
34doxorubicin44 49 1112.3MET, MUC16, AFP, WT1, PIK3CA, ESR2
35alanine4410.3MET, GPX3, AHR, MAP4, AFP, PTHLH
36lactate4410.2AFP, MUC16, PTHLH, SMAD4, PIK3CA
37cysteine4410.2STS, MET, WT1, AHR, ESR2, SMAD2
38map444 2811.2MAP4, STMN1
39threonine4410.2WT1, SMAD4, ACTN4, STMN1, PIK3CA, MET
40progesterone44 59 28 11 2414.2STMN1, PIK3CA, STS, PTHLH, MET, AFP
41arginine4410.2AHR, ANXA4, MET, PIK3CA, WT1, SMAD4
42retinoic acid44 2411.2ESR2, WT1, AHR, HNF1B, PIK3CA, STMN1
43chloramphenicol44 2 1112.2AFP, SMAD4, WT1, ESR2
44vegf4410.2AHR, PTHLH, SMAD2, SMAD4, ESR2, PIK3CA
45testosterone44 59 11 2413.1PIK3CA, WT1, STS, MET, AFP, MUC16
46lipid4410.1PIK3CA, STS, MET, AFP, PTHLH, GPX3
47calcium44 49 11 2413.1ANXA4, AFP, MET, STMN1, STS, PTHLH
48tyrosine4410.0PIK3CA, ANXA4, WT1, STMN1, MUC16, TUBB3
49serine4410.0MUC16, AHR, ACTN4, PTHLH, ESR2, SMAD4
50matrigel449.9SMAD2, PTHLH, MET, PIK3CA

GO Terms for genes affiliated with Clear Cell Adenocarcinoma

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16Gene Ontology
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Cellular components related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activin responsive factor complexGO:03244410.2SMAD4, SMAD2
2transcription factor complexGO:00566710.2SMAD4, SMAD2, AHR, HNF1B
3SMAD protein complexGO:07114110.0SMAD4, SMAD2

Biological processes related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of bindingGO:05109810.5SMAD2, SMAD4
2positive regulation of cellular component movementGO:05127210.4ACTN4, STMN1
3negative regulation of cell growthGO:03030810.4WT1, INHBA, ESR2, SMAD4
4palate developmentGO:06002110.3SMAD4, SMAD2, INHBA
5negative regulation of cell proliferationGO:00828510.3SMAD4, SMAD2, PTHLH, INHBA, WT1
6negative regulation of transcription from RNA polymerase II promoterGO:00012210.3SMAD4, SMAD2, ESR2, AHR, WT1, HNF1B
7SMAD protein complex assemblyGO:00718310.2SMAD4, SMAD2
8positive regulation of transcription, DNA-dependentGO:04589310.1HNF1B, WT1, INHBA, SMAD2, SMAD4
9activin receptor signaling pathwayGO:03292410.0SMAD2, INHBA

Molecular functions related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I-SMAD bindingGO:07041110.3SMAD4, SMAD2
2transcription regulatory region DNA bindingGO:04421210.2SMAD4, AHR, WT1, HNF1B
3sequence-specific DNA binding transcription factor activityGO:0037009.8HNF1B, WT1, AHR, ESR2, SMAD2, SMAD4
4protein bindingGO:0055159.4NEU4, MET, PIK3CA, WT1, HNF1B, MAP4

Products for genes affiliated with Clear Cell Adenocarcinoma

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Sources for Clear Cell Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet