MCID: CLR003
MIFTS: 60

Clear Cell Adenocarcinoma malady

Cancer diseases category

Summaries for Clear Cell Adenocarcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Clear-cell adenocarcinoma is a type of adenocarcinoma. more...

MalaCards: Clear Cell Adenocarcinoma, also known as water-clear cell adenocarcinoma, is related to adenocarcinoma and endometriosis. An important gene associated with Clear Cell Adenocarcinoma is HNF1B (HNF1 homeobox B), and among its related pathways are Axon guidance and Remodeling of Adherens Junctions. The compounds glutamate and leptomycin b have been mentioned in the context of this disorder. Affiliated tissues include cervix, ovary and colon, and related mouse phenotypes are reproductive system and integument.

Disease Ontology:8 An adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

Aliases & Classifications for Clear Cell Adenocarcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

clear cell adenocarcinoma 8 10
water-clear cell adenocarcinoma 8 60
mesonephroid clear cell carcinoma 8
clear cell adenocarcinoma nos 8
adenocarcinoma, clear cell 60
water-clear cell carcinoma 8
adenocarcinoma clear cell 44
mesonephroma, malignant 8
malignant mesonephroma 8
wolffian duct neoplasm 8
mesonephric tumor 60
mesonephroma nos 8
mesonephroma 8


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Disease Ontology8 DOID:4468
NCIt39 C4072
MeSH34 D008649

Related Diseases for Clear Cell Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.0SMAD4, STS, PIK3CA, WT1, HNF1B, STMN1
2endometriosis31.1HNF1B, STS, MUC16, AHR, ESR2
3colon adenocarcinoma30.8AHR, ESR2, SMAD4
4cervical adenocarcinoma30.7MUC16
5adenoma30.7MET, AHR, INHBA, GPX3, ESR2, SMAD4
6ovarian cancer30.6SMAD4, SMAD2, ESR2, MUC16, AFP, MET
7peritonitis30.5MUC16
8rhabdomyosarcoma30.3SMAD4, SMAD2, MET, WT1
9lung adenocarcinoma30.3PIK3CA, STMN1, MET, MUC16, AHR, ESR2
10squamous cell carcinoma30.3ANXA4, MET, STMN1, PIK3CA, MUC16, AHR
11endometrial carcinoma30.1WT1, MUC16, ESR2
12gastric adenocarcinoma30.1PIK3CA, MET, AFP, MUC16, SMAD4
13ovarian cyst30.1ESR2, MUC16
14ovarian clear cell adenocarcinoma11.1
15urethra clear cell adenocarcinoma10.8
16ovary adenocarcinoma10.8
17vaginitis10.8
18urethra adenocarcinoma10.8
19bladder clear cell adenocarcinoma10.8
20bladder adenocarcinoma10.7
21endometrial clear cell adenocarcinoma10.7
22urethritis10.6
23endometrial adenocarcinoma10.6
24cervical clear cell adenocarcinoma10.6
25urethral diverticulum10.5
26cervicitis10.5
27clear cell adenoma10.5
28nephrogenic adenoma10.4
29fallopian tube clear cell adenocarcinoma10.4
30ovarian endometriosis10.4
31clear cell adenofibroma10.4
32adenofibroma10.4
33prostate adenocarcinoma10.4
34prostatitis10.4
35bile duct clear cell adenocarcinoma10.3
36renal clear cell carcinoma10.3
37bladder diffuse clear cell adenocarcinoma10.3
38bladder tubulo-cystic clear cell adenocarcinoma10.3
39bladder papillary clear cell adenocarcinoma10.3
40uterine ligament clear cell adenocarcinoma10.3
41ampulla of vater clear cell adenocarcinoma10.3
42mucinous adenocarcinoma10.3
43cell type cancer10.3
44papillary adenocarcinoma10.3
45endometriosis of ovary10.2
46ovary rhabdomyosarcoma10.2
47nephrogenic adenoma of the urethra10.2
48hypercalcemia10.2
49ureter adenocarcinoma10.2
50renal pelvis adenocarcinoma10.2

Graphical network of the top 20 diseases related to Clear Cell Adenocarcinoma:



Diseases related to clear cell adenocarcinoma

Clinical Features for Clear Cell Adenocarcinoma

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Drugs & Therapeutics for Clear Cell Adenocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Clear Cell Adenocarcinoma

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Anatomical Context for Clear Cell Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Clear Cell Adenocarcinoma:

32
Cervix, Ovary, Colon, Prostate, Uterus, Lung, Kidney, Tongue, Salivary gland, Brain, Lymph node, Pancreas, Smooth muscle, Endothelial, Spleen, Testis

Animal Models for Clear Cell Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Clear Cell Adenocarcinoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.3WT1, PIK3CA, NEU4, AFP, SMAD2, SMAD4
2MP:001077110.3PIK3CA, AHR, SMAD2, SMAD4
3MP:000363110.3ESR2, GPX3, TUBB3
4MP:000538810.2TUBB3, MET, AHR, PTHLH, ESR2, SMAD2
5MP:000200610.2PIK3CA, MET, AFP, AHR, ESR2, SMAD2
6MP:000537910.2HNF1B, WT1, PIK3CA, AFP, AHR, INHBA
7MP:000536910.2HNF1B, WT1, STMN1, MET, AHR, INHBA
8MP:000537010.2HNF1B, WT1, MET, AHR, ESR2, SMAD2
9MP:000537610.2HNF1B, PIK3CA, STMN1, NEU4, AFP, INHBA
10MP:000538110.1MET, AHR, INHBA, PTHLH, ESR2, SMAD2
11MP:000287310.1WT1, STMN1, MET, MAP4, INHBA, ESR2
12MP:000538710.0MET, PIK3CA, WT1, HNF1B, AHR, ACTN4
13MP:000301210.0PIK3CA, MET, AHR, ESR2, SMAD2, WT1
14MP:000536710.0SMAD4, HNF1B, WT1, MET, ANXA4, AHR
15MP:000538510.0WT1, PIK3CA, STMN1, MET, AHR, GPX3
16MP:000538610.0PIK3CA, MET, NEU4, AFP, ANXA4, INHBA
17MP:00053849.9TUBB3, WT1, PIK3CA, MET, NEU4, ACTN4
18MP:00053809.9HNF1B, WT1, PIK3CA, MET, INHBA, SMAD2
19MP:00053789.9HNF1B, WT1, PIK3CA, MET, NEU4, AHR
20MP:00107689.7NEU4, MET, PIK3CA, WT1, TUBB3, HNF1B
21MP:00053979.6WT1, AHR, INHBA, GPX3, PTHLH, ESR2

Publications for Clear Cell Adenocarcinoma

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50PubMed
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Articles related to Clear Cell Adenocarcinoma:

(show top 50)    (show all 379)
idTitleAuthorsYear
1
Primary Urethral Clear-Cell Adenocarcinoma: Comprehensive Analysis by Surgical Pathology, Cytopathology, and Next-Generation Sequencing. (24389164)
2014
2
Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. (23469222)
2013
3
Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1I+, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma. (22498943)
2012
4
Long-term survival in patients with clear cell adenocarcinoma of ovary treated with irinotecan hydrochloride plus cisplatin therapy as first-line chemotherapy. (22639843)
2012
5
Clear cell adenocarcinoma of the uterine cervix in a 24-year-old woman. Case report and review of the literature. (22852019)
2012
6
Successful treatment of an adolescent with locally advanced cervicovaginal clear cell adenocarcinoma using definitive chemotherapy and radiotherapy. (22713709)
2012
7
IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma. (21457161)
2011
8
Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma. (21348943)
2011
9
Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. (20697252)
2010
10
Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinoma. (20486992)
2010
11
Primary peritoneal clear cell adenocarcinoma arising in previous abdominal scar for endometriosis surgery. (19219617)
2009
12
Clear cell adenocarcinoma of the female urethra: magnetic resonance imaging. (19188802)
2009
13
Clear cell adenocarcinoma of the colon: a case report and review of literature. (18286700)
2008
14
Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: evidence of related histogenesis? (18670350)
2008
15
Immunohistochemical detection of hepatocyte nuclear factor 1beta in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium. (17442376)
2007
16
Irinotecan hydrochloride (CPT-11) and cisplatin as first-line chemotherapy after initial surgery for ovarian clear cell adenocarcinoma. (18050828)
2007
17
Proteomic search for potential diagnostic markers and therapeutic targets for ovarian clear cell adenocarcinoma. (17022098)
2006
18
Synchronous invasive squamous cell carcinoma and clear cell adenocarcinoma of the uterine cervix: a different human papillomavirus status. (15896829)
2005
19
A young woman with clear cell adenocarcinoma of the uterine cervix. (14663645)
2003
20
A case of clear cell adenocarcinoma of the mA1llerian duct in persistent mA1llerian duct syndrome: the first reported case. (12218580)
2002
21
Tubulocystic clear cell adenocarcinoma arising within the prostate. (11023108)
2000
22
Clear cell adenocarcinoma of the cervix associated with a rare genitourinary malformation. (11094228)
2000
23
Clear cell adenocarcinoma of the vulva arising in endometriosis. A case report. (11055499)
2000
24
Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. (10206285)
1999
25
Differential diagnosis between monomorphic clear cell adenocarcinoma of salivary glands and renal (clear) cell carcinoma. (10584707)
1999
26
Late recurrence of a uterine clear cell adenocarcinoma confined to an endometrial polyp: case report. (10215432)
1998
27
Clear cell adenocarcinoma of the vagina and cervix. An update of the central Netherlands registry showing twin age incidence peaks. (9179071)
1997
28
Uterine cervical clear-cell adenocarcinoma with a choriocarcinomatous component: a case report. (8987325)
1996
29
Establishment and characterization of two human ovarian clear cell adenocarcinoma lines from metastatic lesions with different properties. (7535723)
1995
30
Histologic correlates of progression-free interval and survival in ovarian clear cell adenocarcinoma. (8406197)
1993
31
Late recurrence of clear cell adenocarcinoma of the vagina and cervix: a report of three cases. (8276306)
1993
32
Clear cell adenocarcinoma of the urinary bladder: report of a case of probable mA1llerian origin. (8483895)
1993
33
Hemihypertrophy, bilateral Wilms' tumor, and clear-cell adenocarcinoma of the uterine cervix in a young girl. (8413002)
1993
34
Characterization of oncogenes (K, N-ras and N, c-myc) in subcloned cell lines (KCC-1a and 1b) derived from same endometrial carcinoma presenting well differentiated adenocarcinoma and clear cell carcinoma]. (1955783)
1991
35
Clear cell adenocarcinoma of the vagina and cervix. A report of the Central Netherlands Registry with emphasis on early detection and prognosis. (2004313)
1991
36
Clear cell adenocarcinoma of the urethra: evidence for origin within paraurethral ducts. (2294240)
1990
37
Vaginal bleeding and diethylstilbestrol exposure during pregnancy: relationship to genital tract clear cell adenocarcinoma and vaginal adenosis in daughters. (2327468)
1990
38
Clear cell adenocarcinoma of the cervix and vagina in a woman with mixed gonadal dysgenesis. A case report. (2621740)
1989
39
Establishment and characterization of cell line SFCC from clear cell adenocarcinoma of the uterine cervix. (2472868)
1989
40
Local therapy in stage I clear cell adenocarcinoma of the vagina. (3621114)
1987
41
Clear cell adenocarcinoma (CCA) of the vagina and cervix in association with pregnancy. (3086191)
1986
42
Risk factors for the development of diethylstilbestrol-associated clear cell adenocarcinoma: a case-control study. (3963071)
1986
43
Primary clear cell adenocarcinoma of the fallopian tube: light microscopic and ultrastructural findings. (7185764)
1982
44
Papillary adenocarcinoma of the prostatic urethra with clear-cell appearance. (7306922)
1981
45
Clear cell adenocarcinoma arising in endometriosis of the rectovaginal septum. (618473)
1978
46
Primary clear-cell adenocarcinoma of the vagina. A case report. (1026665)
1976
47
Clear cell adenocarcinoma of the cervix and vagina. A clinicopathologic study of 21 cases with and without a history of maternal ingestion of estrogens. (1253110)
1976
48
Clinical detection of vaginal adenosis and clear-cell adenocarcinoma. (1167309)
1975
49
Studies of nuclear DNA in vaginal adenosis and clear-cell adenocarcinoma. (4688576)
1973
50
Clear-cell adenocarcinoma in an endometrioid ovarian cyst. (4286320)
1966

Genetic Variations for Clear Cell Adenocarcinoma

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Expression for genes affiliated with Clear Cell Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Clear Cell Adenocarcinoma.

Pathways for genes affiliated with Clear Cell Adenocarcinoma

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 12EMD Millipore
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Compounds for genes affiliated with Clear Cell Adenocarcinoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1glutamate4410.7MAP4, AHR
2leptomycin b44 5911.6SMAD4, SMAD2, PTHLH, AHR
3progestin4410.6ESR2, PTHLH, AHR, STS
4b 7234410.6MUC16, AFP, WT1
5crcs4410.5SMAD4, MET, PIK3CA
6dihydrotestosterone44 28 11 2413.5STS, PTHLH, ESR2, SMAD2, SMAD4
7nocodazole44 1111.5SMAD2, PTHLH, MAP4, STMN1
8estrone44 28 11 2413.5STS, AFP, AHR, ESR2
9agar4410.5PIK3CA, MET, AFP, PTHLH, SMAD4
10dmso4410.5TUBB3, PIK3CA, AFP, AHR, ESR2
11arsenite44 2411.5PIK3CA, STS, AHR
12tgf beta14410.5AFP, PTHLH, SMAD2, SMAD4
13vitamin d4410.5WT1, MET, AFP, AHR, PTHLH, ESR2
14tamoxifen44 49 28 1113.4PIK3CA, STS, AHR, PTHLH, ESR2
15paclitaxel44 49 1112.4TUBB3, PIK3CA, STMN1, AFP, MAP4, MUC16
16pd 98,0594410.4PIK3CA, STMN1, MET, SMAD2, SMAD4
17actinomycin d4410.4PIK3CA, MET, AFP, AHR, PTHLH, ESR2
18dexamethasone44 49 28 1113.4PIK3CA, AFP, MUC16, AHR, GPX3, SMAD2
19thyroxine44 2411.4PTHLH, GPX3, AHR, AFP
20creatinine4410.4WT1, STMN1, AFP, MUC16, GPX3, PTHLH
21cisplatin44 49 59 1113.4TUBB3, PIK3CA, STMN1, MET, AFP, MUC16
22h2o24410.4PIK3CA, AFP, MUC16, ESR2, SMAD2
23paraffin4410.4WT1, MET, AFP, MUC16, PTHLH, ESR2
24heparin44 28 11 2413.4PIK3CA, MET, AFP, ANXA4, GPX3, PTHLH
25thymidine44 2411.4WT1, PIK3CA, STMN1, MET, AFP, PTHLH
26steroid4410.3WT1, PIK3CA, STS, AFP, MUC16, AHR
27ccl444 2811.3PTHLH, AFP, MET
28kaempferol4410.3ESR2, AHR
29nitric oxide44 11 2412.3TUBB3, WT1, PIK3CA, MET, GPX3, PTHLH
30glucose4410.3HNF1B, PIK3CA, MET, MUC16, GPX3, PTHLH
31oligonucleotide4410.3HNF1B, WT1, STS, STMN1, MET, AFP
32estradiol44 11 2412.3STS, AFP, MUC16, AHR, GPX3, PTHLH
33cholesterol44 28 11 2413.3HNF1B, PIK3CA, STS, MET, AFP, GPX3
34doxorubicin44 49 1112.3WT1, PIK3CA, STMN1, MET, AFP, MAP4
35alanine4410.3MET, AFP, MAP4, AHR, GPX3, PTHLH
36lactate4410.2PIK3CA, AFP, MUC16, PTHLH, SMAD4
37cysteine4410.2WT1, STS, MET, ANXA4, AHR, ESR2
38map444 2811.2MAP4, STMN1
39threonine4410.2MET, STMN1, PIK3CA, WT1, AFP, MUC16
40progesterone44 59 28 11 2414.2WT1, PIK3CA, STS, STMN1, MET, AFP
41arginine4410.2MET, PIK3CA, WT1, HNF1B, ANXA4, AHR
42retinoic acid44 2411.2HNF1B, TUBB3, WT1, PIK3CA, STS, STMN1
43chloramphenicol44 2 1112.2WT1, AFP, ESR2, SMAD4
44vegf4410.2WT1, PIK3CA, MET, AFP, MUC16, AHR
45testosterone44 59 11 2413.1SMAD4, WT1, PIK3CA, STS, MET, AFP
46lipid4410.1PIK3CA, STS, MET, AFP, ANXA4, GPX3
47calcium44 49 11 2413.1TUBB3, PIK3CA, STS, STMN1, MET, AFP
48tyrosine4410.0STMN1, STS, PIK3CA, WT1, TUBB3, MET
49serine4410.0MET, STMN1, STS, PIK3CA, WT1, TUBB3
50matrigel449.9PIK3CA, MET, PTHLH, SMAD2

GO Terms for genes affiliated with Clear Cell Adenocarcinoma

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16Gene Ontology
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Cellular components related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activin responsive factor complexGO:03244410.2SMAD4, SMAD2
2transcription factor complexGO:00566710.2SMAD4, SMAD2, AHR, HNF1B
3SMAD protein complexGO:07114110.0SMAD4, SMAD2

Biological processes related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of bindingGO:05109810.5SMAD2, SMAD4
2positive regulation of cellular component movementGO:05127210.4ACTN4, STMN1
3negative regulation of cell growthGO:03030810.4WT1, INHBA, ESR2, SMAD4
4palate developmentGO:06002110.3SMAD4, SMAD2, INHBA
5negative regulation of cell proliferationGO:00828510.3SMAD4, SMAD2, PTHLH, INHBA, WT1
6negative regulation of transcription from RNA polymerase II promoterGO:00012210.3SMAD4, SMAD2, ESR2, AHR, WT1, HNF1B
7SMAD protein complex assemblyGO:00718310.2SMAD4, SMAD2
8positive regulation of transcription, DNA-dependentGO:04589310.1HNF1B, WT1, INHBA, SMAD2, SMAD4
9activin receptor signaling pathwayGO:03292410.0SMAD2, INHBA

Molecular functions related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I-SMAD bindingGO:07041110.3SMAD4, SMAD2
2transcription regulatory region DNA bindingGO:04421210.2SMAD4, AHR, WT1, HNF1B
3sequence-specific DNA binding transcription factor activityGO:0037009.8HNF1B, WT1, AHR, ESR2, SMAD2, SMAD4
4protein bindingGO:0055159.4NEU4, MET, PIK3CA, WT1, HNF1B, MAP4

Products for genes affiliated with Clear Cell Adenocarcinoma

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Sources for Clear Cell Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet