MCID: CLR003
MIFTS: 53

Clear Cell Adenocarcinoma malady

Cancer diseases category
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Summaries for Clear Cell Adenocarcinoma

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Wikipedia:65 Clear-cell adenocarcinoma is a type of adenocarcinoma. more...

MalaCards based summary: Clear Cell Adenocarcinoma, also known as mesonephroid clear cell carcinoma, is related to adenocarcinoma and endometriosis. An important gene associated with Clear Cell Adenocarcinoma is HNF1B (HNF1 homeobox B), and among its related pathways are Selected targets of HNF1 and AHR Pathway. The compounds leptomycin b and dehydroepiandrosterone sulfate have been mentioned in the context of this disorder. Affiliated tissues include cervix, ovary and colon, and related mouse phenotype endocrine/exocrine gland.

Disease Ontology:8 An adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

Aliases & Classifications for Clear Cell Adenocarcinoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
See all sources

Clear Cell Adenocarcinoma, Aliases & Descriptions:

Name: Clear Cell Adenocarcinoma 8 10
Mesonephroid Clear Cell Carcinoma 8 62
Water-Clear Cell Adenocarcinoma 8 62
Mesonephroma, Malignant 8 62
Wolffian Duct Neoplasm 8 62
Clear Cell Adenocarcinoma Nos 8
Water-Clear Cell Carcinoma 8
 
Adenocarcinoma, Clear Cell 62
Adenocarcinoma Clear Cell 44
Malignant Mesonephroma 8
Mesonephric Tumor 62
Mesonephroma Nos 8
Mesonephroma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4468
MeSH34 D008649
NCIt39 C4072

Related Diseases for Clear Cell Adenocarcinoma

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Diseases related to Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7HNF1B, STS, STMN1, PTHLH, AFP, AHR
2endometriosis30.6HOXA10, IGFBP1, AHR, STS, HNF1B
3ovarian cancer30.2AFP, STMN1, STS, HNF1B
4endometrial carcinoma30.1STS, IGFBP1, HOXA10
5ovarian clear cell adenocarcinoma11.1
6vaginitis10.8
7urethritis10.7
8urethral diverticulum10.6
9cervicitis10.6
10cervical clear cell adenocarcinoma10.5
11adenoma10.5
12nephrogenic adenoma10.5
13urethra clear cell adenocarcinoma10.5
14endometrial clear cell adenocarcinoma10.5
15prostatitis10.5
16clear cell adenocarcinoma of ovary10.5
17adenofibroma10.4
18hypoxia10.4
19bile duct clear cell adenocarcinoma10.4
20uterine ligament clear cell adenocarcinoma10.4
21fallopian tube clear cell adenocarcinoma10.4
22ampulla of vater clear cell adenocarcinoma10.4
23bladder tubulo-cystic clear cell adenocarcinoma10.4
24bladder papillary clear cell adenocarcinoma10.4
25bladder clear cell adenocarcinoma10.4
26peritonitis10.4
27leydig cell tumor10.4PTHLH
28bladder diffuse clear cell adenocarcinoma10.3
29clear cell adenofibroma10.3
30hypercalcemia10.3
31renal clear cell carcinoma10.3
32mucinous adenocarcinoma10.3
33ectropion10.3
34endometrial adenocarcinoma10.3
35rhabdomyosarcoma10.3
36transitional cell carcinoma10.3
37adenomyosis10.3
38hemihypertrophy10.3
39teratoma10.3
40wolffian duct adenoma10.2
41pregnancy loss10.2AHR, HOXA10
42primary hyperparathyroidism10.2IGFBP1, PTHLH
43renal cell carcinoma10.1
44wilms tumor10.1
45vulvovaginitis10.1
46renal agenesis10.1
47mixed gonadal dysgenesis10.1
48situs inversus10.1
49salpingitis isthmica nodosa10.1
50epithelial-myoepithelial carcinoma10.1

Graphical network of the top 20 diseases related to Clear Cell Adenocarcinoma:



Diseases related to clear cell adenocarcinoma

Symptoms for Clear Cell Adenocarcinoma

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Drugs & Therapeutics for Clear Cell Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Clear Cell Adenocarcinoma

Search NIH Clinical Center for Clear Cell Adenocarcinoma

Genetic Tests for Clear Cell Adenocarcinoma

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Anatomical Context for Clear Cell Adenocarcinoma

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MalaCards organs/tissues related to Clear Cell Adenocarcinoma:

32
Cervix, Ovary, Colon, Prostate, Kidney, Uterus, Brain, Lung, Salivary gland, Tongue, Lymph node, Spleen, Testis, Endothelial

Animal Models for Clear Cell Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Clear Cell Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.0HNF1B, PTHLH, AFP, AHR, HOXA10

Publications for Clear Cell Adenocarcinoma

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Articles related to Clear Cell Adenocarcinoma:

(show top 50)    (show all 379)
idTitleAuthorsYear
1
Primary clear cell adenocarcinoma of the colon: a case report and review. (25311456)
2014
2
Primary non-clear-cell adenocarcinoma of the vagina in a diethylstilbestrol exposed woman. (24690973)
2014
3
Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. (24669262)
2014
4
Clear Cell Adenocarcinoma of the Prostate: A Rare Oncologic Entity in a 42-Year-Old African American Man. (25217452)
2014
5
Clear cell adenocarcinoma of the renal pelvis: an extremely rare neoplasm of the upper urinary tract. (24375047)
2013
6
Integrative analysis of copy number alteration and gene expression profiling in ovarian clear cell adenocarcinoma. (23726144)
2013
7
ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis. (23762304)
2013
8
ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas. (22348389)
2012
9
Metastatic clear cell adenocarcinoma of the urethra in a male patient: report of a case. (22056213)
2012
10
Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United States. (22015647)
2012
11
IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma. (21457161)
2011
12
Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma. (21348943)
2011
13
Re-expression of estrogen receptor I^ inhibits the proliferation and migration of ovarian clear cell adenocarcinoma cells. (21874257)
2011
14
Biological significance of plasminogen activator inhibitor-1 expression in ovarian clear cell adenocarcinoma. (22335020)
2011
15
Primary clear cell adenocarcinoma of the rectum: a case report. (20405292)
2010
16
Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma. (20546339)
2010
17
HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival. (20009888)
2009
18
Ultrastructural changes of platelet aggregates and fibrin networks in a patient with renal clear cell adenocarcinoma: a scanning electron microscopy study. (19353637)
2009
19
Vaginal clear cell adenocarcinoma with associated MA1llerian duct anomalies, renal agenesis and situs inversus: report of a case with no known in-utero exposure with diethyl stilboestrol. (19757709)
2009
20
A synthetic retinoid, TAC-101 (4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid), plus cisplatin: potential new therapy for ovarian clear cell adenocarcinoma. (18048092)
2008
21
Immunohistochemical detection of hepatocyte nuclear factor 1beta in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium. (17442376)
2007
22
Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma. (16391844)
2006
23
Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis. (16442693)
2006
24
Clear cell adenocarcinoma of the cervix in a child without in utero exposure to diethylstilbestrol: a case report and review of the literature. (16222478)
2005
25
The clear cell adenocarcinoma of the colon: case report and review of the literature. (14557891)
2004
26
Endobronchial clear cell adenocarcinoma occurring in a patient 15 years after treatment for DES-associated vaginal clear cell adenocarcinoma. (15196869)
2004
27
A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. (15350353)
2004
28
Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells. (12114452)
2002
29
Clear cell adenocarcinoma within a tamoxifen-related polyp. (12366493)
2002
30
Clear cell adenocarcinoma of the female urethra showing strong immunostaining for prostate-specific antigen. (11251541)
2001
31
Tubulocystic clear cell adenocarcinoma arising within the prostate. (11023108)
2000
32
Prognostic significance of serous and clear cell adenocarcinoma in surgically staged endometrial carcinoma. (10746848)
2000
33
A pilot study of CPT-11 and cisplatin for ovarian clear cell adenocarcinoma. (10563197)
1999
34
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma. (9022137)
1997
35
p53 protein expression and gene analysis in clear cell adenocarcinoma of the vagina and cervix. (8774636)
1996
36
Primary non-clear cell adenocarcinoma of the vagina in older DES-exposed women. (8641634)
1996
37
Clear cell adenocarcinoma of the colon. (8568005)
1995
38
Clear cell adenocarcinoma of the cervix and vagina in a woman with mixed gonadal dysgenesis. A case report. (2621740)
1989
39
Clear-cell adenocarcinoma of the female urethra. (3856984)
1985
40
Clear cell adenocarcinoma of the bladder and urethra. A report of three cases and review of the literature. (2416225)
1985
41
Colposcopic and pathologic features in two cases of DES-related vaginal clear-cell adenocarcinoma. (6834354)
1983
42
Mucinous adenocarcinoma and clear cell adenocarcinoma arising in separate ovaries. (6293404)
1983
43
Primary clear cell adenocarcinoma of the fallopian tube: light microscopic and ultrastructural findings. (7185764)
1982
44
Development of clear cell adenocarcinoma in DES-exposed offspring under observation. (7088431)
1982
45
Intrauterine diethylstilbestrol exposure and its consequences: pathologic characteristics of vaginal adenosis, clear cell adenocarcinoma, and related lesions. (576195)
1977
46
Clear cell adenocarcinoma of the uterus--ultrastructural and hormonal study. (605800)
1977
47
Clear-cell adenocarcinoma of the cervix in young women. (4473263)
1974
48
Clear cell adenocarcinoma in young females. (4696964)
1973
49
Studies of nuclear DNA in vaginal adenosis and clear-cell adenocarcinoma. (4688576)
1973
50
Clear-cell adenocarcinoma of the uterine body and cervix. (4654058)
1972

Variations for Clear Cell Adenocarcinoma

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Expression for genes affiliated with Clear Cell Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Clear Cell Adenocarcinoma.

Pathways for genes affiliated with Clear Cell Adenocarcinoma

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Pathways related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HNF1B, IGFBP1
2
Show member pathways
AhR pathway37
9.4AHR, IGFBP1
39.1AFP, IGFBP1

Compounds for genes affiliated with Clear Cell Adenocarcinoma

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Compounds related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1leptomycin b44 6110.7AHR, PTHLH
2dehydroepiandrosterone sulfate449.6IGFBP1, STS
3progestins449.6IGFBP1, STS
4diethylstilbestrol44 28 1111.6AFP, HOXA10
5octreotide44 61 28 1112.5IGFBP1, PTHLH
6clomiphene citrate449.5AFP, IGFBP1
7p005449.5IGFBP1, AFP
8forskolin44 50 1111.4IGFBP1, PTHLH, STMN1
9ccl444 2810.4PTHLH, AFP
10dihydrotestosterone44 28 24 1112.3PTHLH, STS, IGFBP1
11pge2449.2PTHLH, IGFBP1, AHR
12vinblastine44 50 1111.2AFP, STMN1
13paclitaxel44 50 1111.1AFP, PTHLH, STMN1
14arginine449.1PTHLH, IGFBP1, AHR, HNF1B
15cycloheximide449.1PTHLH, HOXA10, IGFBP1, AHR
16glycogen44 2410.1AFP, IGFBP1, PTHLH
17dhea449.0STS, IGFBP1
18glutamine448.9AHR, AFP, STMN1
19cisplatin44 50 61 1111.9STMN1, AFP, PTHLH
20lactate448.9IGFBP1, PTHLH, AFP
21hydrogen44 249.9PTHLH, AFP, STS
22progestin448.8IGFBP1, STS, AHR, PTHLH
23tamoxifen44 50 28 1111.8PTHLH, STS, AHR, IGFBP1
24sodium44 249.8IGFBP1, PTHLH, AFP
25glucose448.7AFP, PTHLH, HNF1B, IGFBP1
26thymidine44 249.7STMN1, PTHLH, IGFBP1, AFP
27creatinine448.7IGFBP1, STMN1, PTHLH, AFP
28threonine448.6AFP, PTHLH, STMN1, IGFBP1
29thyroxine44 249.6AFP, AHR, PTHLH, IGFBP1
30heparin44 28 24 1111.6IGFBP1, AFP, PTHLH
31vitamin d448.6AHR, AFP, PTHLH, IGFBP1
32actinomycin d448.6IGFBP1, AHR, AFP, PTHLH
33dexamethasone44 50 28 1111.6AFP, AHR, PTHLH, IGFBP1
34vegf448.6PTHLH, AFP, AHR, IGFBP1
35cholesterol44 28 24 1111.6AFP, HNF1B, IGFBP1, STS
36alanine448.6AFP, PTHLH, AHR, IGFBP1
37glutamate448.5AFP, AHR, IGFBP1, STMN1
38estrone44 28 24 1111.4STS, AFP, AHR, IGFBP1
39lipid448.4IGFBP1, STS, PTHLH, AFP
40oligonucleotide448.3HOXA10, AFP, STMN1, STS, HNF1B
41tyrosine448.2STS, AFP, HOXA10, PTHLH, STMN1
42oxygen44 249.1STMN1, AFP, PTHLH, STS, IGFBP1
43calcium44 50 24 1111.0IGFBP1, AFP, PTHLH, STMN1, STS
44progesterone44 28 61 24 1111.7HOXA10, STMN1, STS, PTHLH, AFP, IGFBP1
45estradiol44 24 119.7STS, AFP, PTHLH, AHR, IGFBP1, HOXA10
46testosterone44 61 24 1110.6AHR, HOXA10, IGFBP1, AFP, PTHLH, STS
47steroid447.6IGFBP1, AFP, HOXA10, PTHLH, STS, AHR
48serine447.5IGFBP1, AHR, AFP, PTHLH, STMN1, STS
49retinoic acid44 248.2HNF1B, STMN1, PTHLH, AFP, AHR, STS
50estrogen447.2AFP, AHR, PTHLH, STS, IGFBP1, STMN1

GO Terms for genes affiliated with Clear Cell Adenocarcinoma

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Cellular components related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.2HNF1B, AHR, HOXA10

Biological processes related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anterior/posterior pattern specificationGO:0099529.8HNF1B, HOXA10
2regulation of gene expressionGO:0104689.5PTHLH, AHR
3epidermis developmentGO:0085449.3STS, PTHLH
4female pregnancyGO:0075659.1STS, PTHLH

Molecular functions related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.6HNF1B, AHR
2sequence-specific DNA bindingGO:0435658.9HNF1B, AHR, HOXA10

Products for genes affiliated with Clear Cell Adenocarcinoma

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Sources for Clear Cell Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet