MCID: CLR003
MIFTS: 58

Clear Cell Adenocarcinoma malady

Cancer category

Summaries for Clear Cell Adenocarcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Clear cell adenocarcinoma is a type of adenocarcinoma. more...

MalaCards: Clear Cell Adenocarcinoma, also known as water-clear cell adenocarcinoma, is related to adenocarcinoma and adenoma. An important gene associated with Clear Cell Adenocarcinoma is HNF1B (HNF1 homeobox B), and among its related pathways are Axon guidance and Remodeling of Adherens Junctions. The compounds glutamate and leptomycin b have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and brain, and related mouse phenotypes are reproductive system and integument.

Disease Ontology:8 An adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

Aliases & Classifications for Clear Cell Adenocarcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

clear cell adenocarcinoma 8 10
water-clear cell adenocarcinoma 8 61
mesonephroid clear cell carcinoma 8
clear cell adenocarcinoma nos 8
adenocarcinoma, clear cell 61
water-clear cell carcinoma 8
adenocarcinoma clear cell 45
mesonephroma, malignant 8
malignant mesonephroma 8
wolffian duct neoplasm 8
mesonephric tumor 61
mesonephroma nos 8
mesonephroma 8


External Ids:

Disease Ontology8 DOID:4468
NCIt40 C4072
MeSH35 D008649

Related Diseases for Clear Cell Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.0STS, PTHLH, STMN1, WT1, ESR2, PIK3CA
2adenoma30.7INHBA, ESR2, SMAD4, GPX3, MET, AHR
3hemihypertrophy30.4WT1
4teratoma30.4AFP
5squamous cell carcinoma30.4MUC16, SMAD4, PIK3CA, MET, AHR, ANXA4
6wilms tumor30.1WT1, ACTN4
7ovarian clear cell adenocarcinoma11.1
8urethra clear cell adenocarcinoma10.9
9urethra adenocarcinoma10.9
10bladder clear cell adenocarcinoma10.8
11bladder adenocarcinoma10.8
12endometrial clear cell adenocarcinoma10.7
13cervical clear cell adenocarcinoma10.6
14urethral diverticulum10.5
15clear cell adenoma10.5
16clear cell adenofibroma10.5
17adenofibroma10.5
18nephrogenic adenoma10.5
19fallopian tube clear cell adenocarcinoma10.5
20ovarian endometriosis10.4
21ovarian epithelial cancer10.4
22hypoxia10.4
23bile duct clear cell adenocarcinoma10.3
24renal clear cell carcinoma10.3
25bladder diffuse clear cell adenocarcinoma10.3
26bladder tubulo-cystic clear cell adenocarcinoma10.3
27bladder papillary clear cell adenocarcinoma10.3
28uterine ligament clear cell adenocarcinoma10.3
29ampulla of vater clear cell adenocarcinoma10.3
30ovary rhabdomyosarcoma10.3
31hypercalcemia10.3
32mucinous adenocarcinoma10.3
33ureter adenocarcinoma10.3
34renal pelvis adenocarcinoma10.3
35bladder diverticulum10.3
36transitional cell carcinoma10.3
37adenomyosis10.3
38clear cell renal cell carcinoma10.3
39rare endometriosis10.3
40wolffian duct adenoma10.2
41squamous cell papilloma10.1
42cervix endometriosis10.1
43endosalpingiosis10.1
44renal agenesis10.1
45salpingitis isthmica nodosa10.1
46ovarian mucinous adenocarcinoma10.1
47cervix squamous papilloma10.1
48urethra transitional cell carcinoma10.1
49maxillary sinus adenocarcinoma10.1
50ovarian squamous cell carcinoma10.1

Graphical network of the top 20 diseases related to Clear Cell Adenocarcinoma:



Diseases related to clear cell adenocarcinoma

Clinical Features for Clear Cell Adenocarcinoma

Drugs & Therapeutics for Clear Cell Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Clear Cell Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Clear Cell Adenocarcinoma

Search NIH Clinical Center for Clear Cell Adenocarcinoma

Search CenterWatch for Clear Cell Adenocarcinoma

Genetic Tests for Clear Cell Adenocarcinoma

Anatomical Context for Clear Cell Adenocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Clear Cell Adenocarcinoma:

33
Lymph node, Spleen, Brain, Smooth muscle, Small intestine, Colon, Kidney, Lung, Pancreas, Salivary gland, Adrenal gland, Ovary, Uterus, Prostate, Testis, Cervix, T cells, Endothelial, Tongue, Testis germ

Animal Models for Clear Cell Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Clear Cell Adenocarcinoma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.3WT1, PIK3CA, NEU4, AFP, SMAD2, SMAD4
2MP:001077110.3PIK3CA, AHR, SMAD2, SMAD4
3MP:000363110.3ESR2, GPX3, TUBB3
4MP:000538810.2TUBB3, MET, AHR, PTHLH, ESR2, SMAD2
5MP:000200610.2PIK3CA, MET, AFP, AHR, ESR2, SMAD2
6MP:000537910.2HNF1B, WT1, PIK3CA, AFP, AHR, INHBA
7MP:000536910.2HNF1B, WT1, STMN1, MET, AHR, INHBA
8MP:000537010.2HNF1B, WT1, MET, AHR, ESR2, SMAD2
9MP:000537610.2HNF1B, PIK3CA, STMN1, NEU4, AFP, INHBA
10MP:000538110.1MET, AHR, INHBA, PTHLH, ESR2, SMAD2
11MP:000287310.1WT1, STMN1, MET, MAP4, INHBA, ESR2
12MP:000538710.0MET, PIK3CA, WT1, HNF1B, AHR, ACTN4
13MP:000301210.0PIK3CA, MET, AHR, ESR2, SMAD2, WT1
14MP:000536710.0SMAD4, HNF1B, WT1, MET, ANXA4, AHR
15MP:000538510.0WT1, PIK3CA, STMN1, MET, AHR, GPX3
16MP:000538610.0PIK3CA, MET, NEU4, AFP, ANXA4, INHBA
17MP:00053849.9TUBB3, WT1, PIK3CA, MET, NEU4, ACTN4
18MP:00053809.9HNF1B, WT1, PIK3CA, MET, INHBA, SMAD2
19MP:00053789.9HNF1B, WT1, PIK3CA, MET, NEU4, AHR
20MP:00107689.7NEU4, MET, PIK3CA, WT1, TUBB3, HNF1B
21MP:00053979.6WT1, AHR, INHBA, GPX3, PTHLH, ESR2

Publications for Clear Cell Adenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Clear Cell Adenocarcinoma:

(show top 50)    (show all 380)
idTitleAuthorsYear
1
Clear cell adenocarcinoma of the renal pelvis: an extremely rare neoplasm of the upper urinary tract. (24375047)
2013
2
ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis. (23762304)
2013
3
Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI. (24172789)
2013
4
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
5
Successful Treatment of a Young Patient with Locally Advanced Clear Cell Adenocarcinoma of the Uterine Cervix Undergoing Chemoradiation Followed by Radical Surgery. (24296792)
2013
6
A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age. (24306200)
2013
7
Primary clear cell adenocarcinoma arising from rectal endometriosis. (23362987)
2013
8
Clear cell adenocarcinoma of the female genital tract: long-term outcome and fertility aspects after brachytherapy aimed at a conservative treatment. (22932263)
2012
9
Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review. (22325372)
2012
10
Histological grading of ovarian clear cell adenocarcinoma: proposal for a simple and reproducible grouping system based on tumor growth architecture. (22317866)
2012
11
Clear cell adenocarcinoma with enteroblastic differentiation of the ascending colon. (21632507)
2011
12
Analysis of mTOR inhibition-involved pathway in ovarian clear cell adenocarcinoma. (21614172)
2011
13
Clear cell adenocarcinoma of the uterine cervix in a young pregnant woman: a case report with immunohistochemical study. (20054717)
2011
14
Expression of podoplanin in epithelial ovarian carcinomas and its potential as a marker for clear cell adenocarcinoma. (20736762)
2010
15
HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival. (20009888)
2009
16
Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. (19020706)
2008
17
Clear cell adenocarcinoma arising in endometriosis of a previous episiotomy site. (18669770)
2008
18
Vaginal clear cell adenocarcinoma with early pulmonary metastasis in a child. (18850481)
2008
19
Clear cell adenocarcinoma of urinary bladder and urethra: another urinary tract lesion immunoreactive for P504S. (18788852)
2008
20
Clear cell adenocarcinoma arising from abdominal wall endometriosis. (19266089)
2008
21
Fertility-sparing radical abdominal trachelectomy for clear cell adenocarcinoma of the upper vagina: a case report. (17399769)
2007
22
Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma. (16391844)
2006
23
PTEN expression in clear cell adenocarcinoma of the ovary. (16290000)
2006
24
Clear cell adenocarcinoma of the cervix in a child without in utero exposure to diethylstilbestrol: a case report and review of the literature. (16222478)
2005
25
Advanced clear-cell adenocarcinoma of the bladder successfully treated by radical surgery with adjuvant chemoradiotherapy. (16247666)
2005
26
Successful diagnosis of thromboembolism before surgery in a woman with clear cell adenocarcinoma of the endometrium. (16369752)
2005
27
Irinotecan hydrochloride (CPT-11) and mitomycin C as the first line chemotherapy for ovarian clear cell adenocarcinoma. (15894369)
2005
28
Antiproliferative effects of interferon-alphaCon1 on ovarian clear cell adenocarcinoma in vitro and in vivo. (15534119)
2004
29
Clear cell adenocarcinoma of the bladder in a male patient: clinicopathologic analysis of a case. (12890970)
2003
30
HER2 is frequently over-expressed in ovarian clear cell adenocarcinoma: possible novel treatment modality using recombinant monoclonal antibody against HER2, trastuzumab. (12460467)
2002
31
Establishment of a new cell line (TAYA) of clear cell adenocarcinoma of the ovary and its radiosensitivity. (11914605)
2002
32
Ovarian endometriosis and clear cell carcinoma, leiomyomatosis peritonealis disseminata, and endometrial adenocarcinoma: an unusual, pathogenetically related association. (11444203)
2001
33
Clear cell adenocarcinoma of the female urethra showing strong immunostaining for prostate-specific antigen. (11251541)
2001
34
Absence of estrogen receptor-alpha expression in human ovarian clear cell adenocarcinoma compared with ovarian serous, endometrioid, and mucinous adenocarcinoma. (11342781)
2001
35
Cyclophosphamide and 5-fluorouracil act synergistically in ovarian clear cell adenocarcinoma cells. (11121861)
2001
36
Cytologic examination to detect clear cell adenocarcinoma of the vagina or cervix. (10600286)
1999
37
Female pseudohermaphroditism due to congenital adrenal hyperplasia complicated by adenocarcinoma of the prostate and clear cell carcinoma of the endometrium. (8929478)
1996
38
Influence of in utero diethylstilbestrol exposure on the prognosis and biologic behavior of vaginal clear-cell adenocarcinoma. (7959291)
1994
39
Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion with ovarian clear cell adenocarcinoma. (1582751)
1992
40
Clear cell adenocarcinoma of the vagina and cervix secondary to intrauterine exposure to diethylstilbestrol. (2263810)
1990
41
Stage II papillary clear cell adenocarcinoma of the vagina during observation in a diethylstilbestrol-exposed daughter. (2909454)
1989
42
Clear-cell adenocarcinoma of the female urethra. (3055610)
1988
43
Benign glandular inclusions in lymph nodes, endosalpingiosis, and salpingitis isthmica nodosa in a young girl with clear cell adenocarcinoma of the cervix. (6837837)
1983
44
Genital clear cell adenocarcinoma. (6662641)
1983
45
Clear cell adenocarcinoma of the female urethra: clinical and ultrastructural study suggesting a unique neoplasm. (7198504)
1982
46
Endobronchial metastases from clear cell adenocarcinoma of the vagina. (7254738)
1981
47
A case of clear cell adenocarcinoma of the vagina in pregnancy. (7470424)
1981
48
Diethylstilbestrol-exposed monozygotic twins discordant for cervicovaginal clear cell adenocarcinoma. (7189642)
1980
49
Clear-cell adenocarcinoma of the uterine body and cervix. (4654058)
1972
50
A mixed "clear-cell" adenocarcinoma with mesonephroma of the ovary. Report of a case with special clinical aspects. (13835758)
1960

Genetic Variations for Clear Cell Adenocarcinoma

Expression for genes affiliated with Clear Cell Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Clear Cell Adenocarcinoma.

Pathways for genes affiliated with Clear Cell Adenocarcinoma

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 53R&D Systems, 12EMD Millipore
See all sources

Compounds for genes affiliated with Clear Cell Adenocarcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1glutamate4510.7MAP4, AHR
2leptomycin b45 6011.6SMAD4, SMAD2, PTHLH, AHR
3progestin4510.6ESR2, PTHLH, AHR, STS
4b 7234510.6MUC16, AFP, WT1
5crcs4510.5SMAD4, MET, PIK3CA
6dihydrotestosterone45 29 11 2413.5STS, PTHLH, ESR2, SMAD2, SMAD4
7nocodazole45 1111.5SMAD2, PTHLH, MAP4, STMN1
8estrone45 29 11 2413.5STS, AFP, AHR, ESR2
9agar4510.5PIK3CA, MET, AFP, PTHLH, SMAD4
10dmso4510.5TUBB3, PIK3CA, AFP, AHR, ESR2
11arsenite45 2411.5PIK3CA, STS, AHR
12tgf beta14510.5AFP, PTHLH, SMAD2, SMAD4
13vitamin d4510.5WT1, MET, AFP, AHR, PTHLH, ESR2
14tamoxifen45 50 29 1113.4PIK3CA, STS, AHR, PTHLH, ESR2
15paclitaxel45 50 1112.4TUBB3, PIK3CA, STMN1, AFP, MAP4, MUC16
16pd 98,0594510.4PIK3CA, STMN1, MET, SMAD2, SMAD4
17actinomycin d4510.4PIK3CA, MET, AFP, AHR, PTHLH, ESR2
18dexamethasone45 50 29 1113.4PIK3CA, AFP, MUC16, AHR, GPX3, SMAD2
19thyroxine45 2411.4PTHLH, GPX3, AHR, AFP
20creatinine4510.4WT1, STMN1, AFP, MUC16, GPX3, PTHLH
21cisplatin45 50 60 1113.4TUBB3, PIK3CA, STMN1, MET, AFP, MUC16
22h2o24510.4PIK3CA, AFP, MUC16, ESR2, SMAD2
23paraffin4510.4WT1, MET, AFP, MUC16, PTHLH, ESR2
24heparin45 29 11 2413.4PIK3CA, MET, AFP, ANXA4, GPX3, PTHLH
25thymidine45 2411.4WT1, PIK3CA, STMN1, MET, AFP, PTHLH
26steroid4510.3WT1, PIK3CA, STS, AFP, MUC16, AHR
27ccl445 2911.3PTHLH, AFP, MET
28kaempferol4510.3ESR2, AHR
29nitric oxide45 11 2412.3TUBB3, WT1, PIK3CA, MET, GPX3, PTHLH
30glucose4510.3HNF1B, PIK3CA, MET, MUC16, GPX3, PTHLH
31oligonucleotide4510.3HNF1B, WT1, STS, STMN1, MET, AFP
32estradiol45 11 2412.3STS, AFP, MUC16, AHR, GPX3, PTHLH
33cholesterol45 29 11 2413.3HNF1B, PIK3CA, STS, MET, AFP, GPX3
34doxorubicin45 50 1112.3WT1, PIK3CA, STMN1, MET, AFP, MAP4
35alanine4510.3MET, AFP, MAP4, AHR, GPX3, PTHLH
36lactate4510.2PIK3CA, AFP, MUC16, PTHLH, SMAD4
37cysteine4510.2WT1, STS, MET, ANXA4, AHR, ESR2
38map445 2911.2MAP4, STMN1
39threonine4510.2MET, STMN1, PIK3CA, WT1, AFP, MUC16
40progesterone45 60 29 11 2414.2WT1, PIK3CA, STS, STMN1, MET, AFP
41arginine4510.2MET, PIK3CA, WT1, HNF1B, ANXA4, AHR
42retinoic acid45 2411.2HNF1B, TUBB3, WT1, PIK3CA, STS, STMN1
43chloramphenicol45 2 1112.2WT1, AFP, ESR2, SMAD4
44vegf4510.2WT1, PIK3CA, MET, AFP, MUC16, AHR
45testosterone45 60 11 2413.1SMAD4, WT1, PIK3CA, STS, MET, AFP
46lipid4510.1PIK3CA, STS, MET, AFP, ANXA4, GPX3
47calcium45 50 11 2413.1TUBB3, PIK3CA, STS, STMN1, MET, AFP
48tyrosine4510.0STMN1, STS, PIK3CA, WT1, TUBB3, MET
49serine4510.0MET, STMN1, STS, PIK3CA, WT1, TUBB3
50matrigel459.9PIK3CA, MET, PTHLH, SMAD2

GO Terms for genes affiliated with Clear Cell Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activin responsive factor complexGO:03244410.2SMAD4, SMAD2
2transcription factor complexGO:00566710.2SMAD4, SMAD2, AHR, HNF1B
3SMAD protein complexGO:07114110.0SMAD4, SMAD2

Biological processes related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of bindingGO:05109810.5SMAD2, SMAD4
2positive regulation of cellular component movementGO:05127210.4ACTN4, STMN1
3negative regulation of cell growthGO:03030810.4WT1, INHBA, ESR2, SMAD4
4palate developmentGO:06002110.3SMAD4, SMAD2, INHBA
5negative regulation of cell proliferationGO:00828510.3SMAD4, SMAD2, PTHLH, INHBA, WT1
6negative regulation of transcription from RNA polymerase II promoterGO:00012210.3SMAD4, SMAD2, ESR2, AHR, WT1, HNF1B
7SMAD protein complex assemblyGO:00718310.2SMAD4, SMAD2
8positive regulation of transcription, DNA-dependentGO:04589310.1HNF1B, WT1, INHBA, SMAD2, SMAD4
9activin receptor signaling pathwayGO:03292410.0SMAD2, INHBA

Molecular functions related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I-SMAD bindingGO:07041110.3SMAD4, SMAD2
2transcription regulatory region DNA bindingGO:04421210.2HNF1B, WT1, AHR, SMAD4
3sequence-specific DNA binding transcription factor activityGO:0037009.8SMAD4, HNF1B, WT1, AHR, ESR2, SMAD2
4protein bindingGO:0055159.4MUC16, WT1, MAP4, NEU4, MET, AHR

Products for genes affiliated with Clear Cell Adenocarcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Clear Cell Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet