MCID: CLR003
MIFTS: 52

Clear Cell Adenocarcinoma malady

Cancer diseases category

Summaries for Clear Cell Adenocarcinoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Clear-cell adenocarcinoma is a type of adenocarcinoma. more...

MalaCards: Clear Cell Adenocarcinoma, also known as water-clear cell adenocarcinoma, is related to adenocarcinoma and endometriosis. An important gene associated with Clear Cell Adenocarcinoma is HNF1B (HNF1 homeobox B), and among its related pathways are Selected targets of HNF1 and AHR Pathway. The compounds leptomycin b and dehydroepiandrosterone sulfate have been mentioned in the context of this disorder. Affiliated tissues include cervix, ovary and colon, and related mouse phenotype endocrine/exocrine gland.

Disease Ontology:9 An adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

Aliases & Classifications for Clear Cell Adenocarcinoma

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9Disease Ontology, 11DISEASES, 63UMLS, 46Novoseek, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

clear cell adenocarcinoma 9 11
water-clear cell adenocarcinoma 9 63
mesonephroid clear cell carcinoma 9
clear cell adenocarcinoma nos 9
water-clear cell carcinoma 9
adenocarcinoma, clear cell 63
adenocarcinoma clear cell 46
mesonephroma, malignant 9
wolffian duct neoplasm 9
malignant mesonephroma 9
mesonephric tumor 63
mesonephroma nos 9
mesonephroma 9


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Disease Ontology9 DOID:4468
NCIt41 C4072
MeSH36 D008649

Related Diseases for Clear Cell Adenocarcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.8HNF1B, STS, STMN1, PTHLH, AFP, AHR
2endometriosis31.1HOXA10, IGFBP1, AHR, STS, HNF1B
3ovarian cancer30.6AFP, STMN1, STS, HNF1B
4endometrial carcinoma30.2STS, IGFBP1, HOXA10
5ovarian clear cell adenocarcinoma11.1
6vaginitis10.9
7urethritis10.7
8urethral diverticulum10.6
9cervicitis10.6
10cervical clear cell adenocarcinoma10.5
11adenoma10.5
12nephrogenic adenoma10.5
13endometrial clear cell adenocarcinoma10.5
14urethra clear cell adenocarcinoma10.4
15adenofibroma10.4
16prostatitis10.4
17hypoxia10.4
18clear cell adenocarcinoma of ovary10.4
19bile duct clear cell adenocarcinoma10.4
20bladder tubulo-cystic clear cell adenocarcinoma10.4
21bladder papillary clear cell adenocarcinoma10.4
22uterine ligament clear cell adenocarcinoma10.4
23fallopian tube clear cell adenocarcinoma10.4
24ampulla of vater clear cell adenocarcinoma10.4
25bladder clear cell adenocarcinoma10.4
26peritonitis10.4
27bladder diffuse clear cell adenocarcinoma10.3
28clear cell adenofibroma10.3
29hypercalcemia10.3
30mucinous adenocarcinoma10.3
31renal clear cell carcinoma10.3
32ectropion10.3
33endometrial adenocarcinoma10.3
34rhabdomyosarcoma10.3
35transitional cell carcinoma10.3
36adenomyosis10.3
37hemihypertrophy10.3
38teratoma10.3
39wolffian duct adenoma10.2
40vulvovaginitis10.1
41nephrogenic adenoma of the urethra10.1
42situs inversus10.1
43epithelial-myoepithelial carcinoma10.1
44endosalpingiosis10.1
45choroiditis10.1
46renal agenesis10.1
47salpingitis isthmica nodosa10.1
48mixed gonadal dysgenesis10.1
49adenosarcoma10.1
50angiosarcoma10.1

Graphical network of the top 20 diseases related to Clear Cell Adenocarcinoma:



Diseases related to clear cell adenocarcinoma

Symptoms for Clear Cell Adenocarcinoma

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Drugs & Therapeutics for Clear Cell Adenocarcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Clear Cell Adenocarcinoma

Search NIH Clinical Center for Clear Cell Adenocarcinoma

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Genetic Tests for Clear Cell Adenocarcinoma

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Anatomical Context for Clear Cell Adenocarcinoma

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34MalaCards
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MalaCards organs/tissues related to Clear Cell Adenocarcinoma:

34
Cervix, Ovary, Colon, Prostate, Kidney, Uterus, Tongue, Salivary gland, Lung, Brain, Lymph node, Testis, Spleen, Endothelial

Animal Models for Clear Cell Adenocarcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Clear Cell Adenocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.0HNF1B, PTHLH, AFP, AHR, HOXA10

Publications for Clear Cell Adenocarcinoma

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Sources:
53PubMed
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Articles related to Clear Cell Adenocarcinoma:

(show top 50)    (show all 360)
idTitleAuthorsYear
1
Primary Urethral Clear-Cell Adenocarcinoma: Comprehensive Analysis by Surgical Pathology, Cytopathology, and Next-Generation Sequencing. (24389164)
2014
2
Clear cell adenocarcinoma of the renal pelvis: an extremely rare neoplasm of the upper urinary tract. (24375047)
2013
3
Integrative analysis of copy number alteration and gene expression profiling in ovarian clear cell adenocarcinoma. (23726144)
2013
4
ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis. (23762304)
2013
5
ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas. (22348389)
2012
6
Metastatic clear cell adenocarcinoma of the urethra in a male patient: report of a case. (22056213)
2012
7
Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United States. (22015647)
2012
8
IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma. (21457161)
2011
9
Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma. (21348943)
2011
10
Re-expression of estrogen receptor I^ inhibits the proliferation and migration of ovarian clear cell adenocarcinoma cells. (21874257)
2011
11
Biological significance of plasminogen activator inhibitor-1 expression in ovarian clear cell adenocarcinoma. (22335020)
2011
12
Primary clear cell adenocarcinoma of the rectum: a case report. (20405292)
2010
13
Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma. (20546339)
2010
14
HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival. (20009888)
2009
15
Ultrastructural changes of platelet aggregates and fibrin networks in a patient with renal clear cell adenocarcinoma: a scanning electron microscopy study. (19353637)
2009
16
Vaginal clear cell adenocarcinoma with associated MA1llerian duct anomalies, renal agenesis and situs inversus: report of a case with no known in-utero exposure with diethyl stilboestrol. (19757709)
2009
17
A synthetic retinoid, TAC-101 (4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid), plus cisplatin: potential new therapy for ovarian clear cell adenocarcinoma. (18048092)
2008
18
Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. (19020706)
2008
19
Immunohistochemical detection of hepatocyte nuclear factor 1beta in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium. (17442376)
2007
20
Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma. (16391844)
2006
21
Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis. (16442693)
2006
22
Clear cell adenocarcinoma of the cervix in a child without in utero exposure to diethylstilbestrol: a case report and review of the literature. (16222478)
2005
23
The clear cell adenocarcinoma of the colon: case report and review of the literature. (14557891)
2004
24
Endobronchial clear cell adenocarcinoma occurring in a patient 15 years after treatment for DES-associated vaginal clear cell adenocarcinoma. (15196869)
2004
25
A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. (15350353)
2004
26
Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells. (12114452)
2002
27
Clear cell adenocarcinoma within a tamoxifen-related polyp. (12366493)
2002
28
Clear cell adenocarcinoma of the female urethra showing strong immunostaining for prostate-specific antigen. (11251541)
2001
29
Tubulocystic clear cell adenocarcinoma arising within the prostate. (11023108)
2000
30
Prognostic significance of serous and clear cell adenocarcinoma in surgically staged endometrial carcinoma. (10746848)
2000
31
A pilot study of CPT-11 and cisplatin for ovarian clear cell adenocarcinoma. (10563197)
1999
32
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma. (9022137)
1997
33
p53 protein expression and gene analysis in clear cell adenocarcinoma of the vagina and cervix. (8774636)
1996
34
Primary non-clear cell adenocarcinoma of the vagina in older DES-exposed women. (8641634)
1996
35
Clear cell adenocarcinoma of the colon. (8568005)
1995
36
Clear cell adenocarcinoma of the vagina and cervix secondary to intrauterine exposure to diethylstilbestrol. (2263810)
1990
37
Clear cell adenocarcinoma of the cervix and vagina in a woman with mixed gonadal dysgenesis. A case report. (2621740)
1989
38
Clear cell adenocarcinoma of the vagina and cervix: incidence, undetected disease, and diethylstilbestrol. (3385459)
1988
39
Clear-cell adenocarcinoma of the female urethra. (3856984)
1985
40
Clear cell adenocarcinoma of the bladder and urethra. A report of three cases and review of the literature. (2416225)
1985
41
Colposcopic and pathologic features in two cases of DES-related vaginal clear-cell adenocarcinoma. (6834354)
1983
42
Mucinous adenocarcinoma and clear cell adenocarcinoma arising in separate ovaries. (6293404)
1983
43
Primary clear cell adenocarcinoma of the fallopian tube: light microscopic and ultrastructural findings. (7185764)
1982
44
Development of clear cell adenocarcinoma in DES-exposed offspring under observation. (7088431)
1982
45
Intrauterine diethylstilbestrol exposure and its consequences: pathologic characteristics of vaginal adenosis, clear cell adenocarcinoma, and related lesions. (576195)
1977
46
Clear cell adenocarcinoma of the uterus--ultrastructural and hormonal study. (605800)
1977
47
Clear-cell adenocarcinoma of the cervix in young women. (4473263)
1974
48
Clear cell adenocarcinoma in young females. (4696964)
1973
49
Studies of nuclear DNA in vaginal adenosis and clear-cell adenocarcinoma. (4688576)
1973
50
Clear-cell adenocarcinoma of the uterine body and cervix. (4654058)
1972

Variations for Clear Cell Adenocarcinoma

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Expression for genes affiliated with Clear Cell Adenocarcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Clear Cell Adenocarcinoma.

Pathways for genes affiliated with Clear Cell Adenocarcinoma

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51PathCards, 13EMD Millipore, 54QIAGEN, 39NCBI BioSystems Database
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Pathways related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HNF1B, IGFBP1
2
Show member pathways
AhR pathway39
9.4AHR, IGFBP1
39.1AFP, IGFBP1

Compounds for genes affiliated with Clear Cell Adenocarcinoma

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1leptomycin b46 6210.7PTHLH, AHR
2dehydroepiandrosterone sulfate469.6STS, IGFBP1
3progestins469.6IGFBP1, STS
4diethylstilbestrol46 30 1211.6AFP, HOXA10
5octreotide46 62 30 1212.5PTHLH, IGFBP1
6clomiphene citrate469.5IGFBP1, AFP
7p005469.5AFP, IGFBP1
8forskolin46 52 1211.4IGFBP1, PTHLH, STMN1
9ccl446 3010.4AFP, PTHLH
10dihydrotestosterone46 30 25 1212.3STS, PTHLH, IGFBP1
11pge2469.2IGFBP1, AHR, PTHLH
12vinblastine46 52 1211.2STMN1, AFP
13paclitaxel46 52 1211.1AFP, PTHLH, STMN1
14arginine469.1IGFBP1, AHR, PTHLH, HNF1B
15cycloheximide469.1HOXA10, IGFBP1, AHR, PTHLH
16glycogen46 2510.1IGFBP1, AFP, PTHLH
17dhea469.0STS, IGFBP1
18glutamine468.9AHR, AFP, STMN1
19cisplatin46 52 62 1211.9STMN1, PTHLH, AFP
20lactate468.9PTHLH, AFP, IGFBP1
21hydrogen46 259.9STS, PTHLH, AFP
22progestin468.8IGFBP1, AHR, PTHLH, STS
23tamoxifen46 52 30 1211.8IGFBP1, AHR, PTHLH, STS
24sodium46 259.8IGFBP1, AFP, PTHLH
25glucose468.7HNF1B, PTHLH, AFP, IGFBP1
26thymidine46 259.7IGFBP1, AFP, PTHLH, STMN1
27creatinine468.7IGFBP1, AFP, PTHLH, STMN1
28threonine468.6STMN1, PTHLH, AFP, IGFBP1
29thyroxine46 259.6IGFBP1, AHR, AFP, PTHLH
30heparin46 30 25 1211.6IGFBP1, AFP, PTHLH
31vitamin d468.6PTHLH, AFP, AHR, IGFBP1
32actinomycin d468.6PTHLH, AFP, AHR, IGFBP1
33dexamethasone46 52 30 1211.6PTHLH, AFP, AHR, IGFBP1
34vegf468.6IGFBP1, AHR, AFP, PTHLH
35cholesterol46 30 25 1211.6IGFBP1, AFP, STS, HNF1B
36alanine468.6IGFBP1, AHR, AFP, PTHLH
37glutamate468.5STMN1, AFP, AHR, IGFBP1
38estrone46 30 25 1211.4STS, AFP, AHR, IGFBP1
39lipid468.4STS, PTHLH, AFP, IGFBP1
40oligonucleotide468.3HOXA10, AFP, STMN1, STS, HNF1B
41tyrosine468.2HOXA10, AFP, PTHLH, STMN1, STS
42oxygen46 259.1IGFBP1, AFP, PTHLH, STMN1, STS
43calcium46 52 25 1211.0IGFBP1, AFP, PTHLH, STMN1, STS
44progesterone46 30 62 25 1211.7HOXA10, IGFBP1, AFP, PTHLH, STMN1, STS
45estradiol46 25 129.7STS, PTHLH, AFP, AHR, IGFBP1, HOXA10
46testosterone46 62 25 1210.6HOXA10, IGFBP1, AHR, AFP, PTHLH, STS
47steroid467.6HOXA10, IGFBP1, AHR, AFP, PTHLH, STS
48serine467.5IGFBP1, AHR, AFP, PTHLH, STMN1, STS
49retinoic acid46 258.2IGFBP1, AHR, AFP, PTHLH, STMN1, STS
50estrogen467.2HOXA10, IGFBP1, AHR, AFP, PTHLH, STMN1

GO Terms for genes affiliated with Clear Cell Adenocarcinoma

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17Gene Ontology
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Cellular components related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.2HNF1B, AHR, HOXA10

Biological processes related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anterior/posterior pattern specificationGO:0099529.8HNF1B, HOXA10
2regulation of gene expressionGO:0104689.5PTHLH, AHR
3epidermis developmentGO:0085449.3STS, PTHLH
4female pregnancyGO:0075659.1STS, PTHLH

Molecular functions related to Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.6HNF1B, AHR
2sequence-specific DNA bindingGO:0435658.9HNF1B, AHR, HOXA10

Products for genes affiliated with Clear Cell Adenocarcinoma

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Sources for Clear Cell Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet