MCID: CLR011
MIFTS: 35

Clear Cell Ependymoma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Ependymoma

MalaCards integrated aliases for Clear Cell Ependymoma:

Name: Clear Cell Ependymoma 12 52 14
Cellular Ependymoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5507

Summaries for Clear Cell Ependymoma

MalaCards based summary : Clear Cell Ependymoma, also known as cellular ependymoma, is related to ependymoma and devriendt syndrome. An important gene associated with Clear Cell Ependymoma is VIM (Vimentin), and among its related pathways/superpathways are Neuroscience and Interleukin-4 and 13 signaling. The drugs Fentanyl and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and cerebellum, and related phenotypes are Increased proliferation and behavior/neurological

Related Diseases for Clear Cell Ependymoma

Diseases related to Clear Cell Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
id Related Disease Score Top Affiliating Genes
1 ependymoma 11.4
2 devriendt syndrome 10.9 GFAP SYP
3 hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 10.9 GFAP SYP
4 dystonia 10.9 GFAP SYP
5 spinal cord ependymoma 10.9 GFAP SYP
6 paranasal sinus cancer 10.9 ENO2 SYP
7 ampulla of vater small cell carcinoma 10.9 ENO2 SYP
8 esophagus leiomyosarcoma 10.9 GFAP VIM
9 neurogenic thoracic outlet syndrome 10.9 SYP VIM
10 benallegue lacete syndrome 10.9 ENO2 VIM
11 childhood choriocarcinoma of the ovary 10.9 ENO2 SYP
12 glomus tumor 10.9 ENO2 SYP
13 cerebellar astrocytoma 10.8 GFAP SYP
14 nodular medulloblastoma 10.8 ENO2 GFAP
15 osteoblastoma 10.8 ENO2 SYP
16 cystitis cystica 10.8 ENO2 SYP
17 small intestine cancer, childhood 10.8 ENO2 SYP
18 pemphigus foliaceus 10.8 ENO2 SYP
19 gallbladder adenocarcinoma 10.8 ENO2 SYP
20 epidermal appendage tumor 10.8 GFAP SYP
21 mucinous ovarian cystadenoma 10.8 GFAP MUC1
22 pineal region yolk sac tumor 10.8 ENO2 VIM
23 chondroid chordoma 10.8 ENO2 SYP
24 mannose-binding lectin protein deficiency 10.8 MUC1 VIM
25 pancoast tumor 10.8 GFAP TP53
26 brain stem astrocytic neoplasm 10.8 GFAP TP53
27 vulvar angiokeratoma 10.8 MUC1 VIM
28 space motion sickness 10.8 GFAP SYP VIM
29 papillary glioneuronal tumor 10.8 GFAP SYP VIM
30 spleen angiosarcoma 10.7 GFAP MUC1 VIM
31 laryngeal neuroendocrine tumor 10.7 GFAP MUC1 VIM
32 enteric pattern testicular yolk sac tumor 10.7 ENO2 MUC1
33 skin papilloma 10.7 ENO2 SYP VIM
34 pyoderma 10.7 GFAP MUC1 VIM
35 vulvar benign neoplasm 10.7 ENO2 GFAP
36 myxoid leiomyosarcoma 10.7 ENO2 VIM
37 intellectual disability-polydactyly-uncombable hair syndrome 10.7 ENO2 GFAP VIM
38 sebaceous adenoma 10.7 MUC1 SYP VIM
39 ganglioglioma 10.7 GFAP MUC1 VIM
40 tendon sheath lipoma 10.7 GFAP TP53
41 pancreatic ductal carcinoma 10.7 MUC1 SYP VIM
42 morbid obesity 10.7 ENO2 MUC1
43 vulvar squamous papilloma 10.7 GFAP MUC1 VIM
44 subependymal glioma 10.7 GFAP MUC1 VIM
45 myoma 10.7 ENO2 MUC1 VIM
46 prostate disease 10.7 GFAP MUC1 VIM
47 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.7 ENO2 MUC1 SYP
48 pancreatic intraductal papillary-colloid carcinoma 10.7 MUC1 VIM
49 cauda equina intradural extramedullary astrocytoma 10.7 ENO2 GFAP SYP
50 bronchus adenoma 10.7 ENO2 MUC1 SYP

Graphical network of the top 20 diseases related to Clear Cell Ependymoma:



Diseases related to Clear Cell Ependymoma

Symptoms & Phenotypes for Clear Cell Ependymoma

GenomeRNAi Phenotypes related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 TP53

MGI Mouse Phenotypes related to Clear Cell Ependymoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 ADGRV1 ENO2 EPB41L3 GFAP MAP2 NF2
2 mortality/aging MP:0010768 10.1 YAP1 ADGRV1 CFH EPB41L3 FANCL GFAP
3 cellular MP:0005384 10.07 OLIG2 RELA TP53 VIM YAP1 CD34
4 nervous system MP:0003631 9.97 ADGRV1 CFH ENO2 EPB41L3 GFAP MAP2
5 neoplasm MP:0002006 9.73 CD34 EPB41L3 NF2 OLIG2 TP53 YAP1
6 respiratory system MP:0005388 9.5 ENO2 NF2 OLIG2 RELA TP53 VIM
7 vision/eye MP:0005391 9.23 CFH GFAP NF2 OLIG2 RELA TP53

Drugs & Therapeutics for Clear Cell Ependymoma

Drugs for Clear Cell Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
4 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
5 Adjuvants, Anesthesia Phase 3
6 Analgesics Phase 3
7 Analgesics, Opioid Phase 3
8 Anesthetics Phase 3
9 Anesthetics, General Phase 3
10 Anesthetics, Intravenous Phase 3
11 Central Nervous System Depressants Phase 3
12 Liver Extracts Phase 3,Phase 1,Phase 2
13 Narcotics Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Anti-Allergic Agents Phase 3
16 Antipruritics Phase 3
17 Dermatologic Agents Phase 3
18 Gastrointestinal Agents Phase 3
19 Histamine Antagonists Phase 3
20 Histamine H1 Antagonists Phase 3
21
Histamine Phosphate Phase 3 51-74-1 65513
22 Neurotransmitter Agents Phase 3
23
Serotonin Phase 3 50-67-9 5202
24 Serotonin Agents Phase 3
25 Serotonin Antagonists Phase 3
26 Cola Nutraceutical Phase 3
27
Bevacizumab Approved, Investigational Phase 2 216974-75-3
28
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
29
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
30
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
31
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
32
Mechlorethamine Approved Phase 1, Phase 2 51-75-2 4033
33
Lapatinib Approved March 2007, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
34 Angiogenesis Inhibitors Phase 2
35 Angiogenesis Modulating Agents Phase 2
36 Antibodies Phase 2
37 Antibodies, Monoclonal Phase 2
38 Immunoglobulins Phase 2
39 Protein Kinase Inhibitors Phase 2,Phase 1
40 Alkylating Agents Phase 1, Phase 2
41 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
42 Etoposide phosphate Phase 1, Phase 2
43 Isophosphamide mustard Phase 1, Phase 2
44 Topoisomerase Inhibitors Phase 1, Phase 2
45
Everolimus Approved Phase 1 159351-69-6 6442177
46
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
47
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030 46835353
48
Busulfan Approved, Investigational Phase 1 55-98-1 2478
49
Lenograstim Approved Phase 1 135968-09-1
50
Melphalan Approved Phase 1 148-82-3 4053 460612

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
3 Bevacizumab and Lapatinib in Children With Recurrent or Refractory Ependymoma Completed NCT00883688 Phase 2 Bevacizumab;Lapatinib
4 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
5 Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Recruiting NCT02722512 Phase 1
6 Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors Active, not recruiting NCT01331135 Phase 1 sirolimus
7 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
8 Molecular-Guided Therapy for Childhood Cancer Recruiting NCT02162732

Search NIH Clinical Center for Clear Cell Ependymoma

Genetic Tests for Clear Cell Ependymoma

Anatomical Context for Clear Cell Ependymoma

MalaCards organs/tissues related to Clear Cell Ependymoma:

39
Liver, Spinal Cord, Cerebellum, Medulla Oblongata, Temporal Lobe, Bone

Publications for Clear Cell Ependymoma

Articles related to Clear Cell Ependymoma:

(show all 28)
id Title Authors Year
1
A case of clear cell ependymoma with bizarre aggressiveness: Are we underestimating its ferocity? ( 28879912 )
2017
2
Clear cell ependymoma with late leptomeningeal and supratentorial metastases. ( 26431995 )
2015
3
Clear cell ependymoma in a dog. ( 23273584 )
2013
4
Clear cell ependymoma with trisomy 19 developing bone metastases. ( 22207400 )
2012
5
Anaplastic clear cell ependymoma of the conus medullaris and cauda equina in a 3-year-old child. ( 22009009 )
2012
6
Supratentorial clear cell ependymoma mimicking oligodendroglioma : case report and review of the literature. ( 22102956 )
2011
7
Intraparenchymal clear cell ependymoma. ( 21713151 )
2011
8
A case of anaplastic clear-cell ependymoma presenting with high erythropoietin concentration and 1p/19q deletions. ( 21643803 )
2011
9
Clear cell ependymoma occurring in the cauda equina. ( 20856665 )
2010
10
Malignant transformation of supratentorial clear cell ependymoma. ( 18647267 )
2009
11
Differentiation of clear cell ependymoma of the cerebellum from hemangioblastoma by thallium-201 single photon emission computed tomography-case report-. ( 20035139 )
2009
12
Clear cell ependymoma: a mimicker of oligodendroglioma--report of three cases. ( 18248576 )
2008
13
Clear cell ependymoma of the temporal lobe in a child: a case report. ( 18097199 )
2008
14
Clear-cell ependymoma: a report of intracortical tumor with significant desmoplasia. ( 18194140 )
2008
15
Clear-cell ependymoma of the cerebellum: a case report. ( 17614003 )
2007
16
Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. ( 17626628 )
2007
17
Imaging features of clear-cell ependymoma of the spinal cord. ( 17279401 )
2007
18
Intramedullary clear cell ependymoma in the thoracic spinal cord: a case with its crush smear and ultrastructural findings. ( 17923743 )
2007
19
[Immunohistochemical study is helpful for the diagnosis of cerebellar clear cell ependymoma with atypical radiological findings--case report]. ( 16277226 )
2005
20
Clear cell ependymoma of the fourth ventricle. ( 15641594 )
2004
21
Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients. ( 14601094 )
2003
22
Clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. ( 12870256 )
2003
23
Case of clear cell ependymoma of medulla oblongata: clinicopathological and immunohistochemical study with literature review. ( 12713564 )
2003
24
Intramedullary clear cell ependymoma in the cervical spinal cord: case report. ( 11126915 )
2000
25
Cerebellar clear cell ependymoma mimicking hemangioblastoma: its clinical and pathological features. ( 10086492 )
1999
26
[Clear cell ependymoma--a case report]. ( 9621365 )
1998
27
Clear cell ependymoma: a mimic of oligodendroglioma: clinicopathologic and ultrastructural considerations. ( 9236838 )
1997
28
Clear cell ependymoma. A histological variant with diagnostic implications. ( 2477945 )
1989

Variations for Clear Cell Ependymoma

Expression for Clear Cell Ependymoma

Search GEO for disease gene expression data for Clear Cell Ependymoma.

Pathways for Clear Cell Ependymoma

Pathways related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.86 ENO2 GFAP MAP2 NF2 SYP
2 11.49 MUC1 TP53 VIM
3 10.98 FANCL RELA TP53
4 10.92 GFAP MAP2 OLIG2 SYP VIM

GO Terms for Clear Cell Ependymoma

Cellular components related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 ADGRV1 CD34 ENO2 EPB41L3 FANCL GFAP
2 cell body GO:0044297 8.65 NF2

Biological processes related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 MUC1 TP53
2 regulation of stem cell proliferation GO:0072091 9.16 NF2 YAP1
3 cellular response to organic substance GO:0071310 9.13 CD68 MAP2 SYP
4 intermediate filament organization GO:0045109 9.1 VIM
5 astrocyte development GO:0014002 9.07 VIM
6 Bergmann glial cell differentiation GO:0060020 8.96 VIM
7 intermediate filament-based process GO:0045103 8.32 VIM

Molecular functions related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 EPB41L3 GFAP VIM
2 structural molecule activity GO:0005198 8.8 EPB41L3 MAP2 VIM

Sources for Clear Cell Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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