MCID: CLR011
MIFTS: 34

Clear Cell Ependymoma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Ependymoma

MalaCards integrated aliases for Clear Cell Ependymoma:

Name: Clear Cell Ependymoma 12 51 14
Cellular Ependymoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5507

Summaries for Clear Cell Ependymoma

MalaCards based summary : Clear Cell Ependymoma, also known as cellular ependymoma, is related to ependymoma and hemangioblastoma. An important gene associated with Clear Cell Ependymoma is VIM (Vimentin), and among its related pathways/superpathways are Neuroscience and Interleukin-4 and 13 signaling. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cerebellum and medulla oblongata, and related phenotypes are Increased proliferation and behavior/neurological

Related Diseases for Clear Cell Ependymoma

Diseases related to Clear Cell Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.8 GFAP MUC1 NF2 RELA SYP VIM
2 hemangioblastoma 30.4 ENO2 GFAP MUC1 SYP
3 oligodendroglioma 29.7 ENO2 GFAP OLIG2 SYP TP53
4 desmoplastic infantile ganglioglioma 10.6 GFAP SYP
5 extraventricular neurocytoma 10.6 GFAP SYP
6 lung combined type small cell carcinoma 10.6 GFAP SYP
7 cutaneous leiomyosarcoma 10.6 GFAP VIM
8 malignant sertoli cell tumor 10.6 ENO2 SYP
9 primary hepatic neuroendocrine carcinoma 10.6 SYP VIM
10 urinary bladder small cell neuroendocrine carcinoma 10.6 ENO2 SYP
11 bednar tumor 10.6 ENO2 VIM
12 pilomatrix carcinoma 10.6 ENO2 MUC1
13 auditory system cancer 10.6 ENO2 SYP
14 cutaneous ganglioneuroma 10.6 ENO2 SYP
15 sensory organ benign neoplasm 10.6 ENO2 SYP
16 melanotic medulloblastoma 10.6 ENO2 GFAP
17 gallbladder small cell carcinoma 10.6 ENO2 SYP
18 gangliocytoma 10.6 GFAP SYP
19 pancreatic somatostatinoma 10.6 ENO2 SYP
20 extrahepatic bile duct adenocarcinoma 10.6 ENO2 SYP
21 small cell carcinoma of the bladder 10.5 ENO2 SYP
22 epulis 10.5 ENO2 VIM
23 orbital cancer 10.5 ENO2 SYP
24 ovarian carcinosarcoma 10.5 ENO2 SYP
25 pilomyxoid astrocytoma 10.5 GFAP SYP
26 frontal convexity meningioma 10.5 GFAP TP53
27 biphasic synovial sarcoma 10.5 MUC1 VIM
28 spindle cell rhabdomyosarcoma 10.5 GFAP MUC1
29 cerebellar medulloblastoma 10.5 ENO2 GFAP
30 epithelioid leiomyosarcoma 10.5 ENO2 VIM
31 gliofibroma 10.5 GFAP TP53
32 epithelioid malignant peripheral nerve sheath tumor 10.5 ENO2 MUC1
33 microcystic adenoma 10.5 ENO2 MUC1
34 angiocentric glioma 10.5 GFAP SYP VIM
35 medulloepithelioma 10.5 GFAP SYP VIM
36 parachordoma 10.5 GFAP MUC1 VIM
37 malignant mixed mullerian tumor 10.5 MUC1 VIM
38 clear cell meningioma 10.5 GFAP MUC1 VIM
39 syringocystadenoma papilliferum 10.5 GFAP MUC1 VIM
40 perivascular epithelioid cell tumor 10.5 MUC1 SYP VIM
41 myxopapillary ependymoma 10.5 GFAP MUC1 VIM
42 primitive neuroectodermal tumor of the cervix uteri 10.5 ENO2 GFAP VIM
43 protoplasmic astrocytoma 10.5 GFAP TP53
44 pulmonary large cell neuroendocrine carcinoma 10.5 ENO2 SYP
45 nodular hidradenoma 10.5 MUC1 VIM
46 syringoma 10.5 GFAP MUC1 VIM
47 sertoli cell tumor 10.5 MUC1 SYP VIM
48 perineurioma 10.5 GFAP MUC1 VIM
49 ossifying fibromyxoid tumor 10.5 ENO2 MUC1 VIM
50 subependymal glioma 10.5 ENO2 GFAP SYP

Graphical network of the top 20 diseases related to Clear Cell Ependymoma:



Diseases related to Clear Cell Ependymoma

Symptoms & Phenotypes for Clear Cell Ependymoma

GenomeRNAi Phenotypes related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 TP53

MGI Mouse Phenotypes related to Clear Cell Ependymoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 VIM YAP1 SYP TP53 GFAP MAP2
2 mortality/aging MP:0010768 10.1 VIM YAP1 RELA FANCL TP53 GFAP
3 cellular MP:0005384 10.07 VIM YAP1 EPB41L3 RELA FANCL GFAP
4 nervous system MP:0003631 9.97 YAP1 VIM SYP TP53 GFAP MAP2
5 neoplasm MP:0002006 9.73 YAP1 EPB41L3 TP53 CD34 NF2 OLIG2
6 respiratory system MP:0005388 9.5 VIM YAP1 RELA TP53 NF2 OLIG2
7 vision/eye MP:0005391 9.28 VIM FANCL TP53 GFAP ADGRV1 NF2

Drugs & Therapeutics for Clear Cell Ependymoma

Drugs for Clear Cell Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Recruiting NCT02722512 Phase 1

Search NIH Clinical Center for Clear Cell Ependymoma

Genetic Tests for Clear Cell Ependymoma

Anatomical Context for Clear Cell Ependymoma

MalaCards organs/tissues related to Clear Cell Ependymoma:

38
Spinal Cord, Cerebellum, Medulla Oblongata, Bone, Temporal Lobe

Publications for Clear Cell Ependymoma

Articles related to Clear Cell Ependymoma:

(show all 28)
# Title Authors Year
1
A case of clear cell ependymoma with bizarre aggressiveness: Are we underestimating its ferocity? ( 28879912 )
2017
2
Clear cell ependymoma with late leptomeningeal and supratentorial metastases. ( 26431995 )
2015
3
Clear cell ependymoma in a dog. ( 23273584 )
2013
4
Anaplastic clear cell ependymoma of the conus medullaris and cauda equina in a 3-year-old child. ( 22009009 )
2012
5
Clear cell ependymoma with trisomy 19 developing bone metastases. ( 22207400 )
2012
6
A case of anaplastic clear-cell ependymoma presenting with high erythropoietin concentration and 1p/19q deletions. ( 21643803 )
2011
7
Intraparenchymal clear cell ependymoma. ( 21713151 )
2011
8
Supratentorial clear cell ependymoma mimicking oligodendroglioma : case report and review of the literature. ( 22102956 )
2011
9
Clear cell ependymoma occurring in the cauda equina. ( 20856665 )
2010
10
Differentiation of clear cell ependymoma of the cerebellum from hemangioblastoma by thallium-201 single photon emission computed tomography-case report-. ( 20035139 )
2009
11
Malignant transformation of supratentorial clear cell ependymoma. ( 18647267 )
2009
12
Clear cell ependymoma of the temporal lobe in a child: a case report. ( 18097199 )
2008
13
Clear cell ependymoma: a mimicker of oligodendroglioma--report of three cases. ( 18248576 )
2008
14
Clear-cell ependymoma: a report of intracortical tumor with significant desmoplasia. ( 18194140 )
2008
15
Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. ( 17626628 )
2007
16
Intramedullary clear cell ependymoma in the thoracic spinal cord: a case with its crush smear and ultrastructural findings. ( 17923743 )
2007
17
Clear-cell ependymoma of the cerebellum: a case report. ( 17614003 )
2007
18
Imaging features of clear-cell ependymoma of the spinal cord. ( 17279401 )
2007
19
[Immunohistochemical study is helpful for the diagnosis of cerebellar clear cell ependymoma with atypical radiological findings--case report]. ( 16277226 )
2005
20
Clear cell ependymoma of the fourth ventricle. ( 15641594 )
2004
21
Case of clear cell ependymoma of medulla oblongata: clinicopathological and immunohistochemical study with literature review. ( 12713564 )
2003
22
Clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. ( 12870256 )
2003
23
Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients. ( 14601094 )
2003
24
Intramedullary clear cell ependymoma in the cervical spinal cord: case report. ( 11126915 )
2000
25
Cerebellar clear cell ependymoma mimicking hemangioblastoma: its clinical and pathological features. ( 10086492 )
1999
26
[Clear cell ependymoma--a case report]. ( 9621365 )
1998
27
Clear cell ependymoma: a mimic of oligodendroglioma: clinicopathologic and ultrastructural considerations. ( 9236838 )
1997
28
Clear cell ependymoma. A histological variant with diagnostic implications. ( 2477945 )
1989

Variations for Clear Cell Ependymoma

Expression for Clear Cell Ependymoma

Search GEO for disease gene expression data for Clear Cell Ependymoma.

Pathways for Clear Cell Ependymoma

Pathways related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 ENO2 GFAP MAP2 NF2 SYP
2 11.49 MUC1 TP53 VIM
3 10.98 FANCL RELA TP53
4 10.92 GFAP MAP2 OLIG2 SYP VIM

GO Terms for Clear Cell Ependymoma

Cellular components related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 ADGRV1 CD34 ENO2 EPB41L3 FANCL GFAP
2 neuron projection GO:0043005 9.46 MAP2 NF2 SYP VIM
3 cell body GO:0044297 9.13 GFAP MAP2 NF2

Biological processes related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 astrocyte development GO:0014002 9.46 GFAP VIM
2 intermediate filament organization GO:0045109 9.43 GFAP VIM
3 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 MUC1 TP53
4 response to inorganic substance GO:0010035 9.37 RELA TP53
5 response to UV-B GO:0010224 9.32 RELA TP53
6 Bergmann glial cell differentiation GO:0060020 9.26 GFAP VIM
7 regulation of stem cell proliferation GO:0072091 9.16 NF2 YAP1
8 cellular response to organic substance GO:0071310 9.13 CD68 MAP2 SYP
9 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 EPB41L3 GFAP VIM
2 structural molecule activity GO:0005198 8.92 EPB41L3 GFAP MAP2 VIM

Sources for Clear Cell Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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