MCID: CLR030
MIFTS: 44

Clear Cell Renal Cell Carcinoma malady

Nephrological, Cancer categories

Summaries for Clear Cell Renal Cell Carcinoma

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Clear cell renal cell carcinoma is a cancer of the kidney.  the name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.  clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von hippel lindau syndrome) may contribute to the development of this type of cancer.  treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy. last updated: 6/1/2012

MalaCards: Clear Cell Renal Cell Carcinoma, also known as clear-cell metastatic renal cell carcinoma, is related to renal clear cell carcinoma and adenocarcinoma. An important gene associated with Clear Cell Renal Cell Carcinoma is CA6 (carbonic anhydrase VI), and among its related pathways are Reversible Hydration of Carbon Dioxide and Cellular response to hypoxia. The compounds 5-aza-2deoxycytidine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and tongue, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Clear Cell Renal Cell Carcinoma

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61UMLS, 43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Nephrological


Aliases & Descriptions:

clear cell renal cell carcinoma 43
clear-cell metastatic renal cell carcinoma 43 61
conventional renal cell carcinoma 61
cystic-multilocular variant 43
clear cell rcc 43


Related Diseases for Clear Cell Renal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Clear Cell Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1renal clear cell carcinoma32.4RASSF1, CA9, VHL, INHA
2adenocarcinoma30.4CA9, PSCA, GRPR, INHA, VHL, RASSF1
3cystadenoma30.4VHL, INHA
4hypoxia10.8
5papillary carcinoma10.7
6multilocular clear cell renal cell carcinoma10.7
7papillary renal cell carcinoma10.7
8papillary renal carcinoma10.7
9adrenal carcinoma10.6
10multilocular cystic renal cell carcinoma10.6
11angiomyolipoma10.5
12hereditary conventional renal cell carcinoma10.4
13clear cell adenoma10.4
14bone carcinoma10.4
15hepatitis c10.4
16small cell carcinoma10.4
17hepatitis b10.4
18granular cell carcinoma10.4
19large cell carcinoma10.4
20adenoma10.4
21adrenocortical carcinoma10.4
22chromophobe renal cell carcinoma10.4
23familial renal cell carcinoma10.4
24renal cell carcinoma, clear cell, somatic10.4
25renal cell carcinoma, somatic10.4
26hepatitis c virus10.4
27parathyroid carcinoma10.3
28lung clear cell carcinoma10.3
29collecting duct carcinoma10.3
30clear cell adenocarcinoma10.3
31sarcomatoid renal cell carcinoma10.3
32hepatitis e10.3
33gastrointestinal stromal tumor10.3
34hepatitis d10.3
35clear cell sarcoma10.3
36mantle cell lymphoma10.3
37phaeochromocytoma10.3
38paraganglioma10.3
39adrenal adenoma10.3
40bladder carcinoma10.3
41systemic mastocytosis10.3
42vascular cancer10.3
43horseshoe kidney10.3
44mastocytosis10.3
45germ cell tumors10.3
46teratoma10.3
47tubulocystic carcinoma10.3
48chromosome 3p deletion10.2
49kidney cancer10.0CD70, VHL, RASSF1, INHA, CA9
50prostate cancer10.0RASSF1, INHA, GRPR, PSCA, CA9

Graphical network of the top 20 diseases related to Clear Cell Renal Cell Carcinoma:



Diseases related to clear cell renal cell carcinoma

Clinical Features for Clear Cell Renal Cell Carcinoma

Drugs & Therapeutics for Clear Cell Renal Cell Carcinoma

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Clear Cell Renal Cell Carcinoma

Anatomical Context for Clear Cell Renal Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Clear Cell Renal Cell Carcinoma:

33
Ovary, Liver, Tongue, Brain, Kidney, Lymph node, Lung, Whole blood, Smooth muscle, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Prostate, T cells, B cells, Endothelial, Pituitary

Animal Models for Clear Cell Renal Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Clear Cell Renal Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.8VHL, PSCA, INHA, RASSF1, TCF21
2MP:000287310.6VHL, PSCA, GRPR, INHA, RASSF1, TCF21

Publications for Clear Cell Renal Cell Carcinoma

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51PubMed
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Articles related to Clear Cell Renal Cell Carcinoma:

(show top 50)    (show all 790)
idTitleAuthorsYear
1
Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma. (24182559)
2014
2
Quantification of peripheral blood CD133 mRNA in identifying metastasis and in predicting recurrence of patients with clear cell renal cell carcinoma. (24054866)
2014
3
Tumor necrosis on magnetic resonance imaging correlates with aggressive histology and disease progression in clear cell renal cell carcinoma. (24145001)
2014
4
Characteristic MRI findings of sarcomatoid renal cell carcinoma dedifferentiated from clear cell renal carcinoma: radiological-pathological correlation. (23834905)
2013
5
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. (24136229)
2013
6
Key pathways and genes controlling the development and progression of clear cell renal cell carcinoma (ccRCC) based on gene set enrichment analysis. (23943374)
2013
7
Increased expression of ALDH1A1 protein is associated with poor prognosis in clear cell renal cell carcinoma. (23585015)
2013
8
Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC). (23785518)
2013
9
The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis. (23969937)
2013
10
Cyclooxygenase-2 expression and its prognostic significance in clear cell renal cell carcinoma. (23110009)
2012
11
Gain of chromosome 8q is associated with metastases and poor survival of patients with clear cell renal cell carcinoma. (22605478)
2012
12
Preliminary study of whole-body diffusion-weighted imaging in detecting pulmonary metastatic lesions from clear cell renal cell carcinoma: comparison with CT. (21903870)
2011
13
Clear cell papillary renal cell carcinoma in the bilateral native kidneys after 2a88years of renal transplantation: report of a case and review of the literature. (23198258)
2011
14
High-level expression of stem cell marker CD133 in clear cell renal cell carcinoma with favorable prognosis. (22848273)
2011
15
Application of simplified Fuhrman grading system in clear-cell renal cell carcinoma. (20804473)
2011
16
miRNA profiling for clear cell renal cell carcinoma: biomarker discovery and identification of potential controls and consequences of miRNA dysregulation. (21784468)
2011
17
Knockdown of VEGF receptor-1 (VEGFR-1) impairs macrophage infiltration, angiogenesis and growth of clear cell renal cell carcinoma (CRCC). (21989163)
2011
18
Prediction of clear cell renal cell carcinoma by integrity of cell-free DNA in serum. (19962739)
2010
19
Neoadjuvant temsirolimus effectiveness in downstaging advanced non-clear cell renal cell carcinoma. (20347211)
2010
20
Obesity, cholesterol, and clear-cell renal cell carcinoma (RCC). (20399960)
2010
21
Expression of nuclear FIH independently predicts overall survival of clear cell renal cell carcinoma patients. (20709525)
2010
22
Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma. (20454689)
2010
23
Clinical significance of serum levels of endostatin in patients with clear cell renal cell carcinoma]. (19615205)
2009
24
Multifocal brain metastases in clear cell renal cell carcinoma with complete response to sunitinib. (19996660)
2009
25
Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy. (19240241)
2009
26
Thymidylate synthetase allelic imbalance in clear cell renal carcinoma. (19306093)
2009
27
A case of tubulocystic carcinoma simultaneously occurring with clear cell type renal cell carcinoma and micropapillary urothelial carcinoma of bladder. (19488016)
2009
28
Sunitinib treatment for patients with advanced clear-cell renal-cell carcinoma after progression on sorafenib. (19321976)
2009
29
siRNA targeting survivin inhibits growth and induces apoptosis in human renal clear cell carcinoma 786-O cells. (19628339)
2009
30
Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma. (18464292)
2008
31
Prognostic role of histological necrosis for nonmetastatic clear cell renal cell carcinoma: correlation with pathological features and molecular markers. (18707725)
2008
32
Renal cell carcinomas with papillary architecture and clear cell components: the utility of immunohistochemical and cytogenetical analyses in differential diagnosis. (18779729)
2008
33
Carbonic anhydrase IX expression in clear cell renal cell carcinomas negatively correlates with the proportion of the granular cell component. (18669473)
2008
34
C-reactive Protein in Patients with Metastatic Clear Cell Renal Carcinoma: An Important Biomarker for Tumor-associated Inflammation. (19690640)
2007
35
Overexpression of E2F1 in clear cell renal cell carcinoma: a potential impact of erroneous regulation by thyroid hormone nuclear receptors. (17910524)
2007
36
Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. (17699851)
2007
37
Elevated cyclin E level in human clear cell renal cell carcinoma: possible causes and consequences. (17726548)
2007
38
Biomarkers in clear cell renal cell carcinoma. (18062748)
2007
39
Different isoform patterns for vascular endothelial growth factor between clear cell and papillary renal cell carcinoma. (16643499)
2006
40
Differentiation of renal clear cell carcinoma and renal papillary carcinoma using quantitative CT enhancement parameters. (15505308)
2004
41
Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. (15198927)
2004
42
Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. (14764125)
2004
43
Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. (12883249)
2003
44
VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma. (12381710)
2002
45
Specific von Hippel-Lindau protein expression of clear cell renal cell carcinoma with "immunogenic" features. (11349220)
2001
46
Topotecan (Hycamtin) responsiveness in human renal carcinoma cell lines of the clear cell and papillary types. (11848517)
2001
47
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. (11431362)
2001
48
Expression of thyroid hormone receptors is disturbed in human renal clear cell carcinoma. (10822129)
2000
49
Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas. (7585599)
1995
50
Metastatic renal clear cell carcinoma of the jaws. Two cases illustrating clinical and pathological diagnostic problems. (2135656)
1990

Genetic Variations for Clear Cell Renal Cell Carcinoma

Expression for genes affiliated with Clear Cell Renal Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Renal Cell Carcinoma

Search GEO for disease gene expression data for Clear Cell Renal Cell Carcinoma.

Pathways for genes affiliated with Clear Cell Renal Cell Carcinoma

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54Reactome, 30KEGG
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Compounds for genes affiliated with Clear Cell Renal Cell Carcinoma

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45Novoseek, 60Tocris Bioscience, 11DrugBank
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Compounds related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine4510.6SEMA3B, RASSF1, CA9, VHL
2tyrosine4510.6VHL, CA9, HAVCR1, DOK4, GRPR, INHA
3ellagic acid45 60 1112.6CA9, CA6

GO Terms for genes affiliated with Clear Cell Renal Cell Carcinoma

Sources:
16Gene Ontology
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Biological processes related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bicarbonate transportGO:01570110.6CA9, CA6
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.5CA9, VHL
3one-carbon metabolic processGO:00673010.3CA9, CA6

Molecular functions related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbonate dehydratase activityGO:00408910.6CA9, CA6

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Sources for Clear Cell Renal Cell Carcinoma

3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
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48OMIM via Orphanet
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