MCID: CLR030
MIFTS: 44

Clear Cell Renal Cell Carcinoma malady

Rare diseases, Nephrological diseases, Cancer diseases categories

Summaries for Clear Cell Renal Cell Carcinoma

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Clear cell renal cell carcinoma is a cancer of the kidney.  the name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.  clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von hippel lindau syndrome) may contribute to the development of this type of cancer.  treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy. last updated: 6/1/2012

MalaCards: Clear Cell Renal Cell Carcinoma, also known as clear-cell metastatic renal cell carcinoma, is related to hemangioblastoma and cystadenoma. An important gene associated with Clear Cell Renal Cell Carcinoma is CA6 (carbonic anhydrase VI), and among its related pathways are Nitrogen metabolism and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The compounds zonisamide and Carbonic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:66 The Clear Cell Renal Cell Carcinoma (CCRCC) is a type of Renal cell carcinoma. more...

Aliases & Classifications for Clear Cell Renal Cell Carcinoma

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63UMLS, 44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

clear cell renal cell carcinoma 44
clear-cell metastatic renal cell carcinoma 44 63
conventional renal cell carcinoma 63
cystic-multilocular variant 44
clear cell rcc 44


Related Diseases for Clear Cell Renal Cell Carcinoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Clear Cell Renal Cell Carcinoma:



Diseases related to clear cell renal cell carcinoma

Symptoms for Clear Cell Renal Cell Carcinoma

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Drugs & Therapeutics for Clear Cell Renal Cell Carcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Genetic Tests for Clear Cell Renal Cell Carcinoma

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Anatomical Context for Clear Cell Renal Cell Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Clear Cell Renal Cell Carcinoma:

34
Kidney, Endothelial, T cells, Thyroid, Bone, Brain, Lymph node, Colon, Lung, Smooth muscle, Adrenal gland, Breast, Prostate, Pancreas

Animal Models for Clear Cell Renal Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Clear Cell Renal Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4BAP1, VHL, TCF21, INHA
2MP:00053818.8CA9, CA6, VHL, TCF21, INHA

Publications for Clear Cell Renal Cell Carcinoma

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53PubMed
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Articles related to Clear Cell Renal Cell Carcinoma:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Attenuation of krA1ppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. (23861801)
2013
2
Effects of TGF-I^ signaling in clear cell renal cell carcinoma cells. (23618868)
2013
3
Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. (23887297)
2013
4
Roles of transcriptional factor Snail and adhesion factor E-cadherin in clear cell renal cell carcinoma. (24255679)
2013
5
BAP1 Immunohistochemistry in a Multi-Institutional Cohort Predicts Outcomes in Patients with Clear Cell Renal Cell Carcinoma. (24076305)
2013
6
Angiomyolipoma with minimal fat and non-clear cell renal cell carcinoma: differentiation on MDCT using classification and regression tree analysis-based algorithm. (24259298)
2013
7
Monitoring of plasma cell-free DNA in predicting postoperative recurrence of clear cell renal cell carcinoma. (23860338)
2013
8
Molecular imaging and carbonic anhydrase IX-targeted radioimmunotherapy in clear cell renal cell carcinoma. (23638744)
2013
9
Higher Expression of Topoisomerase II Alpha Is an Independent Marker of Increased Risk of Cancer-specific Death in Patients with Clear Cell Renal Cell Carcinoma. (24388441)
2013
10
Dysregulation of beta-catenin is an independent predictor of oncological outcomes in patients with clear cell renal cell carcinoma. (24291548)
2013
11
Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin. (23896380)
2013
12
Breast metastasis from clear cell renal cell carcinoma. (24432163)
2013
13
Serum miR-210 as a novel biomarker for molecular diagnosis of clear cell renal cell carcinoma. (23064048)
2013
14
Fibronectin 1 protein expression in clear cell renal cell carcinoma. (22740994)
2012
15
Alterations of the WNT7A gene in clear cell renal cell carcinomas. (23056560)
2012
16
Genetic pathways involved in carcinogenesis of clear cell renal cell carcinoma: genomics towards personalized medicine. (22035299)
2012
17
Genome-wide microRNA expression analysis of clear cell renal cell carcinoma by next generation deep sequencing. (22745662)
2012
18
Expression of BNIP3 and its correlations to HIF-1alpha and VEGF in clear cell renal cell carcinoma]. (22455137)
2012
19
Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma. (22862160)
2012
20
Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma--a multicentre study. (22698386)
2012
21
Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. (21229250)
2011
22
Preliminary study of whole-body diffusion-weighted imaging in detecting pulmonary metastatic lesions from clear cell renal cell carcinoma: comparison with CT. (21903870)
2011
23
High Jagged1 expression predicts poor outcome in clear cell renal cell carcinoma. (21062756)
2011
24
Expression of the Forkhead transcription factor FOXP1 is associated with tumor grade and Ki67 expression in clear cell renal cell carcinoma. (21210727)
2011
25
MiR-138 suppresses expression of hypoxia-inducible factor 1I+ (HIF-1I+) in clear cell renal cell carcinoma 786-O cells. (21875287)
2011
26
Role of inflammatory related gene expression in clear cell renal cell carcinoma development and clinical outcomes. (21944129)
2011
27
High-level expression of stem cell marker CD133 in clear cell renal cell carcinoma with favorable prognosis. (22848273)
2011
28
Anti-CD10 (56C6) is expressed variably in adrenocortical tumors and cannot be used to discriminate clear cell renal cell carcinomas. (20390424)
2010
29
Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy. (21129210)
2010
30
Epigenetic inactivation of HOXA5 and MSH2 gene in clear cell renal cell carcinoma. (20846263)
2010
31
Distinguishing clear cell renal cell carcinoma, retroperitoneal paraganglioma, and adrenal cortical lesions on limited biopsy material: utility of immunohistochemical markers. (20861762)
2010
32
NDRG2 suppresses the proliferation of clear cell renal cell carcinoma cell A-498. (20673333)
2010
33
A proposal for reclassification of the Fuhrman grading system in patients with clear cell renal cell carcinoma. (19573980)
2009
34
A low frequency of lymph node metastasis in clear-cell renal cell carcinoma is related to low lymphangiogenic activity. (19154467)
2009
35
Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia. (18660794)
2009
36
PET/CT imaging of clear cell renal cell carcinoma with I labeled chimeric antibody. (21789055)
2009
37
Clinical significance of serum levels of endostatin in patients with clear cell renal cell carcinoma]. (19615205)
2009
38
Organ-confined clear cell renal cell carcinoma: the prognostic impact of microvascular invasion, nuclear grade and tumour size. (19133004)
2008
39
Sporadic clear cell renal cell carcinoma with diffuse cytokeratin 7 immunoreactivity. (18604734)
2008
40
Prognostic significance of tenascin-C expression in clear cell renal cell carcinoma. (18695899)
2008
41
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma. (18241036)
2008
42
Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. (17572184)
2007
43
Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. (18094421)
2007
44
DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma. (17443497)
2007
45
High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile. (17505508)
2007
46
Altered expression of members of the IGF-axis in clear cell renal cell carcinoma. (15753986)
2005
47
Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma. (15809750)
2005
48
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. (16024619)
2005
49
Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma. (15086915)
2004
50
Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. (10976699)
2000

Variations for Clear Cell Renal Cell Carcinoma

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Expression for genes affiliated with Clear Cell Renal Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Renal Cell Carcinoma

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Pathways for genes affiliated with Clear Cell Renal Cell Carcinoma

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51PathCards, 31KEGG, 56Reactome
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Compounds for genes affiliated with Clear Cell Renal Cell Carcinoma

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1zonisamide46 52 1211.9CA9, CA6
2Carbonic acid259.8CA9, CA6
3ellagic acid46 62 1211.6CA9, CA6

GO Terms for genes affiliated with Clear Cell Renal Cell Carcinoma

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17Gene Ontology
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Biological processes related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1one-carbon metabolic processGO:0067309.9CA6, CA9
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.8CA9, VHL
3bicarbonate transportGO:0157019.6CA9, CA6
4negative regulation of cell proliferationGO:0082859.4RNF139, BAP1, VHL, PBRM1

Molecular functions related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbonate dehydratase activityGO:0040899.9CA9, CA6

Products for genes affiliated with Clear Cell Renal Cell Carcinoma

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Sources for Clear Cell Renal Cell Carcinoma

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4CDC
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15FMA
23GTR
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25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
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