MCID: CLR030
MIFTS: 32

Clear Cell Renal Cell Carcinoma malady

Nephrological diseases, Cancer diseases categories

Summaries for Clear Cell Renal Cell Carcinoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Clear cell renal cell carcinoma is a cancer of the kidney.  the name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.  clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von hippel lindau syndrome) may contribute to the development of this type of cancer.  treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy. last updated: 6/1/2012

MalaCards: Clear Cell Renal Cell Carcinoma, also known as clear-cell metastatic renal cell carcinoma, is related to renal clear cell carcinoma and hemangioblastoma. An important gene associated with Clear Cell Renal Cell Carcinoma is CA6 (carbonic anhydrase VI), and among its related pathways are Reversible Hydration of Carbon Dioxide and Cellular response to hypoxia. The compounds 5-aza-2deoxycytidine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are tumorigenesis and normal.

Wikipedia:63 The Clear Cell Renal Cell Carcinoma (CCRCC) is a type of Renal cell carcinoma. more...

Aliases & Classifications for Clear Cell Renal Cell Carcinoma

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

clear cell renal cell carcinoma 42
clear-cell metastatic renal cell carcinoma 42 60
conventional renal cell carcinoma 60
cystic-multilocular variant 42
clear cell rcc 42


Related Diseases for Clear Cell Renal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Clear Cell Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1renal clear cell carcinoma32.4RASSF1, CA9, VHL, INHA
2hemangioblastoma30.9VHL, INHA
3kidney cancer30.7CD70, VHL, RASSF1, INHA, CA9
4adenocarcinoma30.3CA9, PSCA, GRPR, INHA, VHL, RASSF1
5cystadenoma30.3VHL, INHA
6meningioma30.3INHA
7renal cell carcinoma11.6
8papillary carcinoma10.7
9multilocular clear cell renal cell carcinoma10.7
10papillary renal cell carcinoma10.7
11adrenal carcinoma10.6
12angiomyolipoma10.5
13obesity10.5
14transitional cell carcinoma10.5
15hereditary conventional renal cell carcinoma10.4
16clear cell adenoma10.4
17bone carcinoma10.4
18small cell carcinoma10.4
19large cell carcinoma10.4
20hepatitis a10.4
21adenoma10.4
22adrenocortical carcinoma10.4
23hemangioma10.4
24hepatitis10.4
25renal adenoma10.4
26renal oncocytoma10.4
27thyroiditis10.4
28parathyroid carcinoma10.2
29lung clear cell carcinoma10.2
30collecting duct carcinoma10.2
31clear cell adenocarcinoma10.2
32sarcomatoid renal cell carcinoma10.2
33eosinophilic variant of chromophobe renal cell carcinoma10.2
34gastrointestinal stromal tumor10.2
35sarcomatoid transitional cell carcinoma10.2
36mantle cell lymphoma10.2
37phaeochromocytoma10.2
38paraganglioma10.2
39adrenal adenoma10.2
40bladder carcinoma10.2
41capillary hemangioma10.2
42chordoma10.2
43clear cell meningioma10.2
44cystic kidney10.2
45hypertension10.2
46kidney disease10.2
47mature teratoma10.2
48melanoma10.2
49prostatitis10.2
50renal hypertension10.2

Graphical network of the top 20 diseases related to Clear Cell Renal Cell Carcinoma:



Diseases related to clear cell renal cell carcinoma

Clinical Features for Clear Cell Renal Cell Carcinoma

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Drugs & Therapeutics for Clear Cell Renal Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Clear Cell Renal Cell Carcinoma

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Anatomical Context for Clear Cell Renal Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Clear Cell Renal Cell Carcinoma:

32
Kidney

Animal Models for Clear Cell Renal Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Clear Cell Renal Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.8TCF21, RASSF1, INHA, PSCA, VHL
2MP:000287310.6SEMA3B, VHL, PSCA, GRPR, INHA, RASSF1

Publications for Clear Cell Renal Cell Carcinoma

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Genetic Variations for Clear Cell Renal Cell Carcinoma

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Expression for genes affiliated with Clear Cell Renal Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Renal Cell Carcinoma

Search GEO for disease gene expression data for Clear Cell Renal Cell Carcinoma.

Pathways for genes affiliated with Clear Cell Renal Cell Carcinoma

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53Reactome, 29KEGG
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Compounds for genes affiliated with Clear Cell Renal Cell Carcinoma

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44Novoseek, 59Tocris Bioscience, 11DrugBank
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Compounds related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine4410.6SEMA3B, RASSF1, CA9, VHL
2tyrosine4410.6VHL, CA9, HAVCR1, DOK4, GRPR, INHA
3ellagic acid44 59 1112.6CA9, CA6

GO Terms for genes affiliated with Clear Cell Renal Cell Carcinoma

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16Gene Ontology
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Biological processes related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bicarbonate transportGO:01570110.6CA9, CA6
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.5CA9, VHL
3one-carbon metabolic processGO:00673010.3CA9, CA6

Molecular functions related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbonate dehydratase activityGO:00408910.6CA9, CA6

Products for genes affiliated with Clear Cell Renal Cell Carcinoma

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  • Antibodies
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Sources for Clear Cell Renal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet