MCID: CLR030
MIFTS: 44

Clear Cell Renal Cell Carcinoma malady

Rare diseases, Nephrological diseases, Cancer diseases categories
Download this MalaCard

Summaries for Clear Cell Renal Cell Carcinoma

About this section


Fully expand this MalaCard
NIH Rare Diseases:42 Clear cell renal cell carcinoma is a cancer of the kidney.  the name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.  clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von hippel lindau syndrome) may contribute to the development of this type of cancer.  treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy. last updated: 6/1/2012

MalaCards based summary: Clear Cell Renal Cell Carcinoma, also known as clear-cell metastatic renal cell carcinoma, is related to hemangioblastoma and renal clear cell carcinoma. An important gene associated with Clear Cell Renal Cell Carcinoma is CA6 (carbonic anhydrase VI), and among its related pathways are Nitrogen metabolism and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The compounds zonisamide and Carbonic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:65 The Clear Cell Renal Cell Carcinoma (CCRCC) is a type of Renal cell carcinoma. more...

Aliases & Classifications for Clear Cell Renal Cell Carcinoma

About this section

Clear Cell Renal Cell Carcinoma, Aliases & Descriptions:

Name: Clear Cell Renal Cell Carcinoma 42
Clear-Cell Metastatic Renal Cell Carcinoma 42 62
Conventional Renal Cell Carcinoma 62
 
Cystic-Multilocular Variant 42
Clear Cell Rcc 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


Related Diseases for Clear Cell Renal Cell Carcinoma

About this section

Graphical network of the top 20 diseases related to Clear Cell Renal Cell Carcinoma:



Diseases related to clear cell renal cell carcinoma

Symptoms for Clear Cell Renal Cell Carcinoma

About this section

Drugs & Therapeutics for Clear Cell Renal Cell Carcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Clear Cell Renal Cell Carcinoma

Search NIH Clinical Center for Clear Cell Renal Cell Carcinoma

Genetic Tests for Clear Cell Renal Cell Carcinoma

About this section

Anatomical Context for Clear Cell Renal Cell Carcinoma

About this section

MalaCards organs/tissues related to Clear Cell Renal Cell Carcinoma:

32
Kidney, Endothelial, T cells, Bone, Lymph node, Brain, Thyroid, Neutrophil, Smooth muscle, Colon, Lung, Pancreas, Adrenal gland, Breast, Prostate

Animal Models for Clear Cell Renal Cell Carcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Clear Cell Renal Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4BAP1, VHL, TCF21, INHA
2MP:00053818.8CA9, CA6, VHL, TCF21, INHA

Publications for Clear Cell Renal Cell Carcinoma

About this section

Articles related to Clear Cell Renal Cell Carcinoma:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Pseudogene PTENP1 functions as a competing endogenous RNA to suppress clear cell renal cell carcinoma progression. (25249556)
2014
2
A Clearer View of the Molecular Complexity of Clear Cell Renal Cell Carcinoma. (25387056)
2014
3
High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinoma. (25337221)
2014
4
Attenuation of krA1ppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. (23861801)
2013
5
Effects of TGF-I^ signaling in clear cell renal cell carcinoma cells. (23618868)
2013
6
Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. (23887297)
2013
7
Roles of transcriptional factor Snail and adhesion factor E-cadherin in clear cell renal cell carcinoma. (24255679)
2013
8
BAP1 Immunohistochemistry in a Multi-Institutional Cohort Predicts Outcomes in Patients with Clear Cell Renal Cell Carcinoma. (24076305)
2013
9
Angiomyolipoma with minimal fat and non-clear cell renal cell carcinoma: differentiation on MDCT using classification and regression tree analysis-based algorithm. (24259298)
2013
10
Monitoring of plasma cell-free DNA in predicting postoperative recurrence of clear cell renal cell carcinoma. (23860338)
2013
11
Molecular imaging and carbonic anhydrase IX-targeted radioimmunotherapy in clear cell renal cell carcinoma. (23638744)
2013
12
Higher Expression of Topoisomerase II Alpha Is an Independent Marker of Increased Risk of Cancer-specific Death in Patients with Clear Cell Renal Cell Carcinoma. (24388441)
2013
13
Dysregulation of beta-catenin is an independent predictor of oncological outcomes in patients with clear cell renal cell carcinoma. (24291548)
2013
14
Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin. (23896380)
2013
15
Breast metastasis from clear cell renal cell carcinoma. (24432163)
2013
16
Serum miR-210 as a novel biomarker for molecular diagnosis of clear cell renal cell carcinoma. (23064048)
2013
17
Fibronectin 1 protein expression in clear cell renal cell carcinoma. (22740994)
2012
18
Alterations of the WNT7A gene in clear cell renal cell carcinomas. (23056560)
2012
19
Genetic pathways involved in carcinogenesis of clear cell renal cell carcinoma: genomics towards personalized medicine. (22035299)
2012
20
Genome-wide microRNA expression analysis of clear cell renal cell carcinoma by next generation deep sequencing. (22745662)
2012
21
Expression of BNIP3 and its correlations to HIF-1alpha and VEGF in clear cell renal cell carcinoma]. (22455137)
2012
22
Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma. (22862160)
2012
23
Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma--a multicentre study. (22698386)
2012
24
Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. (21229250)
2011
25
Preliminary study of whole-body diffusion-weighted imaging in detecting pulmonary metastatic lesions from clear cell renal cell carcinoma: comparison with CT. (21903870)
2011
26
High Jagged1 expression predicts poor outcome in clear cell renal cell carcinoma. (21062756)
2011
27
Expression of the Forkhead transcription factor FOXP1 is associated with tumor grade and Ki67 expression in clear cell renal cell carcinoma. (21210727)
2011
28
MiR-138 suppresses expression of hypoxia-inducible factor 1I+ (HIF-1I+) in clear cell renal cell carcinoma 786-O cells. (21875287)
2011
29
Role of inflammatory related gene expression in clear cell renal cell carcinoma development and clinical outcomes. (21944129)
2011
30
Anti-CD10 (56C6) is expressed variably in adrenocortical tumors and cannot be used to discriminate clear cell renal cell carcinomas. (20390424)
2010
31
Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy. (21129210)
2010
32
Epigenetic inactivation of HOXA5 and MSH2 gene in clear cell renal cell carcinoma. (20846263)
2010
33
Distinguishing clear cell renal cell carcinoma, retroperitoneal paraganglioma, and adrenal cortical lesions on limited biopsy material: utility of immunohistochemical markers. (20861762)
2010
34
NDRG2 suppresses the proliferation of clear cell renal cell carcinoma cell A-498. (20673333)
2010
35
A proposal for reclassification of the Fuhrman grading system in patients with clear cell renal cell carcinoma. (19573980)
2009
36
A low frequency of lymph node metastasis in clear-cell renal cell carcinoma is related to low lymphangiogenic activity. (19154467)
2009
37
Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia. (18660794)
2009
38
PET/CT imaging of clear cell renal cell carcinoma with I labeled chimeric antibody. (21789055)
2009
39
Clinical significance of serum levels of endostatin in patients with clear cell renal cell carcinoma]. (19615205)
2009
40
Organ-confined clear cell renal cell carcinoma: the prognostic impact of microvascular invasion, nuclear grade and tumour size. (19133004)
2008
41
Sporadic clear cell renal cell carcinoma with diffuse cytokeratin 7 immunoreactivity. (18604734)
2008
42
Prognostic significance of tenascin-C expression in clear cell renal cell carcinoma. (18695899)
2008
43
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma. (18241036)
2008
44
Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. (17572184)
2007
45
Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. (18094421)
2007
46
DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma. (17443497)
2007
47
Altered expression of members of the IGF-axis in clear cell renal cell carcinoma. (15753986)
2005
48
Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma. (15809750)
2005
49
Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma. (15086915)
2004
50
Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. (10976699)
2000

Variations for Clear Cell Renal Cell Carcinoma

About this section

Expression for genes affiliated with Clear Cell Renal Cell Carcinoma

About this section
Expression patterns in normal tissues for genes affiliated with Clear Cell Renal Cell Carcinoma

Search GEO for disease gene expression data for Clear Cell Renal Cell Carcinoma.

Pathways for genes affiliated with Clear Cell Renal Cell Carcinoma

About this section

Compounds for genes affiliated with Clear Cell Renal Cell Carcinoma

About this section

Compounds related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1zonisamide44 50 1111.9CA9, CA6
2Carbonic acid249.8CA9, CA6
3ellagic acid44 61 1111.6CA9, CA6

GO Terms for genes affiliated with Clear Cell Renal Cell Carcinoma

About this section

Biological processes related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bicarbonate transportGO:0157019.9CA9, CA6
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.8VHL, CA9
3one-carbon metabolic processGO:0067309.6CA9, CA6
4negative regulation of cell proliferationGO:0082859.4BAP1, VHL, PBRM1, RNF139

Molecular functions related to Clear Cell Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbonate dehydratase activityGO:0040899.9CA9, CA6

Products for genes affiliated with Clear Cell Renal Cell Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Clear Cell Renal Cell Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet