MCID: CLR017
MIFTS: 52

Clear Cell Sarcoma malady

Cancer diseases category

Summaries for Clear Cell Sarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. it presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

MalaCards: Clear Cell Sarcoma, also known as melanoma, malignant, of soft parts, is related to sarcoma and melanoma. An important gene associated with Clear Cell Sarcoma is ATF1 (activating transcription factor 1), and among its related pathways are RSK activation and Striated Muscle Contraction. The compounds glycogen and creatinine have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and lymph node, and related mouse phenotypes are muscle and normal.

Wikipedia:63 Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer... more...

Aliases & Classifications for Clear Cell Sarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

clear cell sarcoma 8 10
melanoma, malignant, of soft parts 8
adult soft part clear cell sarcoma 8
malignant melanoma of soft tissues 8
clear cell sarcoma of soft parts 8
sarcoma, clear cell 60
sarcoma clear cell 44


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Disease Ontology8 DOID:4233
NCIt39 C3745
MeSH34 D018227

Related Diseases for Clear Cell Sarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Clear Cell Sarcoma family:

Small Cell Sarcoma

Diseases related to Clear Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.0ENO2, VIM, S100B, S100A1, EWSR1, TFE3
2melanoma31.4VIM, S100B, S100A1, EWSR1, MFI2, CREB1
3spindle cell sarcoma30.5VIM, S100B, DES, ACTC1
4synovial sarcoma30.3VIM, S100B, DES
5adenoma30.3S100A1, H19, CREB1, ACTC1, ENO2
6alveolar soft part sarcoma30.1TFE3
7neuroblastoma30.1ENO2
8myxoid liposarcoma30.1ATF1, DDIT3, EWSR1
9paraganglioma30.1ENO2, S100A1, S100B
10osteosarcoma30.1DDIT3, CREB1, H19
11liposarcoma30.1VIM, EWSR1, DDIT3, DES
12giant cell tumor30.1VIM, S100B, DES, ACTC1
13malignant mesothelioma30.1VIM, S100A1, DES
14pleomorphic adenoma30.1VIM, S100B, S100A1, DES, ACTC1
15microphthalmia30.1S100B, TFE3, CREB1, MLANA, ACTC1
16chondrosarcoma30.1VIM, S100B, S100A1, EWSR1, DDIT3, DES
17rhabdomyosarcoma30.1VIM, S100B, S100A1, H19, EWSR1, DDIT3
18kidney clear cell sarcoma11.1
19kidney sarcoma11.1
20small cell sarcoma10.4
21epithelioid sarcoma10.3
22tendinitis10.2
23clear cell adenoma10.2
24brain sarcoma10.2
25sarcomatosis10.2
26lung sarcoma10.2
27peritonitis10.2
28melanoma of soft part10.2
29choroiditis10.1
30amelanotic melanoma10.1
31familial adenomatous polyposis10.1
32pleomorphic liposarcoma10.1
33familial melanoma10.1
34epithelioid cell synovial sarcoma10.1
35penis sarcoma10.1
36metanephric adenoma10.1
37acral lentiginous melanoma10.1
38gastroduodenitis10.1
39pediatric lymphoma10.1
40clear cell chondrosarcoma10.1
41arthritis10.1
42colon sarcoma10.1
43congenital mesoblastic nephroma10.1
44kidney disease10.1
45malignant pleural mesothelioma10.1
46mediastinum sarcoma10.1
47neuroma10.1
48ovary sarcoma10.1
49pericardial effusion10.1
50pulmonary embolism10.1

Graphical network of the top 20 diseases related to Clear Cell Sarcoma:



Diseases related to clear cell sarcoma

Clinical Features for Clear Cell Sarcoma

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Drugs & Therapeutics for Clear Cell Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Clear Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Clear Cell Sarcoma

Search NIH Clinical Center for Clear Cell Sarcoma

Search CenterWatch for Clear Cell Sarcoma

Genetic Tests for Clear Cell Sarcoma

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Anatomical Context for Clear Cell Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Clear Cell Sarcoma:

32
Kidney, Bone, Lymph node, Tongue, Brain, Lung, Small intestine, Skin, Ovary, Colon

Animal Models for Clear Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Clear Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0ERBB3, ACTC1, CREB1, H19
2MP:00028739.1ERBB3, S100B, S100A1, H19, EWSR1, TFE3

Publications for Clear Cell Sarcoma

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50PubMed
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Articles related to Clear Cell Sarcoma:

(show top 50)    (show all 371)
idTitleAuthorsYear
1
Outcomes of patients with revised stage I clear cell sarcoma of kidney treated in National Wilms Tumor Studies 1-5. (22658515)
2013
2
Diagnostic dilemma: late presentation of amelanotic BRAF-negative metastatic malignant melanoma resembling clear cell sarcoma - a case report. (24274261)
2013
3
Cutaneous clear cell sarcoma in a 12-year-old boy. (23668220)
2013
4
Clear cell sarcoma of the jejunum: a case report. (23351137)
2013
5
Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney. (22294382)
2012
6
Clear cell sarcoma of the parotid region. (23108833)
2012
7
Identification of biomarkers to distinguish clear cell sarcoma from malignant melanoma. (22406360)
2012
8
Primary clear cell sarcoma of the sacrum: a case report. (21181468)
2011
9
Boron neutron capture therapy for clear cell sarcoma (CCS): biodistribution study of p-borono-L-phenylalanine in CCS-bearing animal models. (21367607)
2011
10
Discovery of two novel EWSR1/ATF1 transcripts in four chimerical transcripts-expressing clear cell sarcoma and their quantitative evaluation. (21185830)
2011
11
Anaplastic variant of clear cell sarcoma of the kidney: a rare case report. (20601342)
2010
12
Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma. (20068147)
2010
13
Clear cell sarcoma: a rare entity within melanoma. (19560955)
2009
14
Ultrastructure in resolving a diagnosis of poorly differentiated clear cell sarcoma of soft parts in an adolescent male. (18603710)
2008
15
Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models. (18566246)
2008
16
The proteome profile of two cell lines and their xenografts isolated from a patient with clear cell sarcoma (soft tissue melanoma). (18820372)
2008
17
Clear cell sarcoma of soft tissues. (17192915)
2007
18
Clear cell sarcoma of the kidney--a study of seven cases over a period of three years. (17883043)
2007
19
Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma. (16258500)
2005
20
An unusual case of clear cell sarcoma arising in the jejunum highlights the diagnostic value of molecular genetic techniques in establishing a correct diagnosis. (15810965)
2005
21
Clear cell sarcoma in the era of sentinel lymph node mapping. (15334639)
2004
22
Primary clear cell sarcoma (malignant melanoma) in the right radius. (12904909)
2003
23
Clear cell sarcoma of the stomach. (12460205)
2002
24
Clear cell sarcoma (malignant melanoma of soft parts): case report and review of the literature. (12391930)
2002
25
A clinicopathological study of clear cell sarcoma of the kidney]. (11866983)
2001
26
Malignant melanoma is genetically distinct from clear cell sarcoma of tendons and aponeurosis (malignant melanoma of soft parts). (11207050)
2001
27
Triple central ray amputation for clear cell sarcoma of the hand. (10746475)
2000
28
Concurrent chemoimmunotherapy in metastatic clear cell sarcoma: a case report. (10774576)
1999
29
Melanoma of the soft parts (clear cell sarcoma): a case report and review of the literature. (9591793)
1998
30
Fine needle aspiration cytology of clear cell sarcoma of the kidney. A case report. (9850658)
1998
31
Malignant melanoma of soft parts (clear cell sarcoma)--a rare case of multiorgan localization]. (9729915)
1998
32
Establishment of a new continuous clear cell sarcoma cell line. Morphological and cytogenetic characterization and detection of chimaeric EWS/ATF-1 transcripts. (9247632)
1997
33
Primary malignant melanoma (clear cell sarcoma) of bone: report of a case arising in the ulna. (8640695)
1996
34
Clear cell sarcoma mimicking peripheral nerve sheath tumor. (8848756)
1996
35
Carcinoma of the tongue in a long-term survivor of clear cell sarcoma of the kidney. (8597820)
1995
36
Keratin immunoreactivity in melanoma of soft parts (clear cell sarcoma). (7557908)
1995
37
Establishment and characterization of a clear-cell sarcoma (malignant melanoma of soft parts) cell line. (8060155)
1994
38
Familial adenomatous polyposis coli and clear cell sarcoma of the kidney. (8385323)
1993
39
Clear cell sarcoma of kidney. Two cases in adults. (8453549)
1993
40
An unusual presentation of clear cell sarcoma. (17587039)
1992
41
Clear cell sarcoma of soft tissues. Mayo Clinic experience with 35 cases. (1463095)
1992
42
Ectopic ACTH syndrome due to clear cell sarcoma of the kidney. (1661639)
1991
43
Fine-needle aspiration biopsy of clear-cell sarcoma of the kidney: light and electron microscopic features. (2550191)
1989
44
Human sarcomatous Wilms' tumor lines: evidence for epithelial differentiation in clear cell sarcoma of the kidney. (2475248)
1989
45
Clear cell sarcoma of kidney (CCSK)--a clinicopathological study of 4 cases. (2591997)
1989
46
Clear cell sarcoma of the kidney--a case report. (2631749)
1989
47
Clear cell sarcoma of the tendinous portion of the quadriceps muscle at the knee joint managed by limb-sparing surgery. (3030474)
1986
48
Spinal melanotic clear-cell sarcoma: a light and electron microscopic study. (7397634)
1980
49
Clear-cell sarcoma of tendons and aponeuroses. Report of two cases. (920114)
1977
50
Clear cell sarcoma with melanin pigment. (1182685)
1975

Genetic Variations for Clear Cell Sarcoma

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Expression for genes affiliated with Clear Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Sarcoma

Search GEO for disease gene expression data for Clear Cell Sarcoma.

Pathways for genes affiliated with Clear Cell Sarcoma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ATF1, CREB1
2
Hide members
10.1VIM, DES, ACTC1
310.1ATF1, DDIT3, CREB1
49.9ATF1, DDIT3, TFE3, EWSR1
5
Hide members
9.7ERBB3, DES, ATF1, DDIT3, CREB1, VIM

Compounds for genes affiliated with Clear Cell Sarcoma

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44Novoseek, 24HMDB, 49PharmGKB, 2BitterDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1glycogen44 2411.6ACTC1, CREB1
2creatinine4410.6ACTC1
3askin4410.5ENO2, EWSR1
42-methoxyethanol4410.5VIM, S100A1, ACTC1
5orcein4410.4ACTC1, DES, S100B, VIM
6edss4410.4ENO2, S100B
7reticulin4410.4ACTC1, DES, S100B, VIM
8eosin4410.4VIM, S100B
9actomyosin4410.4VIM, S100A1, ACTC1
10azathioprine44 49 2 1113.3DES, CREB1, H19, VIM
11toluidine4410.3VIM, S100A1, DES, ENO2
12acetylcholine44 49 28 11 2414.3S100A1, CREB1, ERBB3, ENO2
13glucose4410.3TFE3, DDIT3, ACTC1, ERBB3
14mucicarmine4410.3VIM, S100B, S100A1, DES, ACTC1
15dbc-amp4410.3VIM, S100B, CREB1, ENO2
16b 7234410.3VIM, S100B, S100A1, DES, ACTC1
17biotin44 11 2412.3ACTC1, DES, S100A1, VIM
18s 1004410.2VIM, S100B, DES, ACTC1, ENO2
19glutamine4410.2EWSR1, CREB1, DDIT3, ENO2
20agar4410.2VIM, H19, CREB1, ERBB3
21formaldehyde44 2411.2VIM, S100B, DES, ACTC1, ENO2
22acth4410.2ENO2, CREB1, H19, S100B
23ganglioside4410.1VIM, DES, ENO2
24bromodeoxyuridine4410.1VIM, S100B, DDIT3, DES, ENO2
25norepinephrine44 11 2412.1S100B, CREB1, ATF1, DES, ENO2
26gaba4410.1ENO2, CREB1, S100B, VIM
27cyclic amp44 2411.1VIM, S100B, EWSR1, CREB1, ATF1, DES
28etoposide44 49 59 1113.1VIM, S100B, CREB1, DDIT3, ENO2
29forskolin44 49 1112.1VIM, S100B, CREB1, ATF1, ERBB3, ENO2
30adenylate4410.0VIM, S100B, CREB1, ATF1, DES, ENO2
31steroid4410.0H19, CREB1, MLANA, ATF1, DES, ACTC1
32lactate4410.0VIM, S100B, CREB1, MLANA, DES, ENO2
33zinc44 2411.0S100B, S100A1, H19, EWSR1, MFI2, CREB1
3412-o-tetradecanoylphorbol 13-acetate4410.0VIM, CREB1, ATF1, DES
35heparin44 28 11 2413.0ENO2, ERBB3, DES, S100B, VIM
36hematoxylin449.9VIM, S100B, S100A1, MLANA, DES, ACTC1
37methionine449.9DES, DDIT3, S100B, VIM
38leucine449.9VIM, S100B, TFE3, CREB1, DDIT3, ATF1
39progesterone44 59 28 11 2413.8VIM, S100B, S100A1, ATF1, DES, ACTC1
40sb 20358044 5910.8ATF1, DDIT3, CREB1, VIM
41testosterone44 59 11 2412.8VIM, S100B, CREB1, DDIT3, DES, ACTC1
42iron44 2410.8VIM, S100B, S100A1, MFI2, DDIT3, DES
43vegf449.8VIM, S100B, CREB1, DDIT3, DES, ACTC1
44atp44 2810.7VIM, S100B, S100A11, CREB1, DDIT3, ERBB3
45silver449.7S100A1, DES, ENO2
46oxygen44 2410.7ENO2, ACTC1, DES, DDIT3, MFI2, S100B
47paraffin449.6ENO2, VIM, S100B, S100A1, H19, EWSR1
48retinoic acid44 2410.5VIM, S100B, S100A1, H19, EWSR1, CREB1
49tyrosine449.5S100B, S100A1, H19, EWSR1, CREB1, DDIT3
50calcium44 49 11 2412.3S100B, S100A1, S100A11, EWSR1, CREB1, DDIT3

GO Terms for genes affiliated with Clear Cell Sarcoma

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16Gene Ontology
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Biological processes related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.1ACTC1, DES, VIM

Molecular functions related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.9S100A11, S100A1, S100B
2identical protein bindingGO:0428029.4VIM, S100B, S100A1, EWSR1, DES, ERBB3
3protein bindingGO:0055158.7S100B, S100A1, S100A11, EWSR1, MFI2, CREB1

Products for genes affiliated with Clear Cell Sarcoma

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Sources for Clear Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet