Clear Cell Sarcoma malady

Disease Ontology: A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. it presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.⁶

MalaCards: Clear Cell Sarcoma, also known as malignant melanoma of soft tissues (disorder), is related to synovial sarcoma and kaposi's sarcoma. An important gene associated with Clear Cell Sarcoma is ATF1 (activating transcription factor 1), and among its related pathways are Signal transduction_PTEN pathway and ErbB2-ErbB3 Heterodimers. The drugs ifosfamide and interferon alfa 2-b and the compounds ly294002 and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, kidney and lung, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Wikipedia: Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer...⁴⁴ more...

Aliases & Descriptions:

clear cell sarcoma 6 8 malignant melanoma of soft tissues (disorder) 6 clear cell sarcoma (morphologic abnormality) 6 melanoma, malignant, of soft parts 6 adult soft part clear cell sarcoma 6 clear cell sarcoma of soft parts 6

sarcoma, clear cell 43 sarcoma clear cell 32 cutaneous melanoma 43 melanoma 43 sarcoma 43

Diseases related to clear cell sarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 867)

id	Related Disease	Score	Top Affiliating Genes
1	synovial sarcoma	35.7	VIM, S100B, MKI67, MDM2, IGF2, DES
2	kaposi's sarcoma	34.4	PCNA, VIM, BRAF, MYC, MKI67, MDM2
3	endometrial stromal sarcoma	34.1	VIM, PDGFRA, ACTC1, DES
4	alveolar soft part sarcoma	33.6	VIM, MLH1, ENO2, TFE3, DES
5	melanoma metastasis	33.5	S100B, ATF1, MITF, TP53, PTEN, CREB1
6	ocular melanoma	33.4	VIM, S100A11, S100B, PDGFRA
7	epithelioid sarcoma	33.2	VIM, S100B, EGFR, DES
8	kidney clear cell sarcoma	33.0	BRAF, S100B, ATF1, MITF, IGF2, EWSR1
9	peripheral primitive neuroectodermal tumor	32.6	ATF1, MDM2, ENO2, EWSR1, WT1, DES
10	amelanotic melanoma	32.6	S100A1, S100B, TYR
11	lentigo maligna melanoma	31.6	S100B, MLANA, MITF
12	breast cancer	31.4	MLH1, MDM2, TP53, PTEN, H19
13	skin melanoma	31.4	PCNA, S100B, MLH1, MKI67, TP53, TYR
14	intraocular melanoma	31.3	MKI67, EGFR
15	spindle cell sarcoma	31.3	VIM, S100B, MKI67, TP53
16	cutaneous malignant melanoma	31.2	PCNA, BRAF, MYC, S100B, MLANA, MLH1
17	superficial spreading melanoma	31.1	MYC, S100B, MLANA, MITF
18	extraosseous ewing's sarcoma	30.8	S100B, EWSR1
19	nodular melanoma	30.7	BRAF, MYC, S100B, MLANA, MKI67, MITF
20	uterine sarcoma	30.7	MYC, MLH1, MKI67, MDM2, PTEN, PDGFRA
21	botryoid rhabdomyosarcoma	30.5	WT1, ACTC1, DES
22	vulvar melanoma	30.5	ATF1, MLANA
23	meninges sarcoma	30.4	VIM, DES
24	posterior uveal melanoma	30.4	PCNA, BRAF, MLANA, MKI67, MITF, TYR
25	skin cancer	30.3	PCNA, VIM, MLANA, MDM2, ERBB3, TP53
26	retroperitoneal sarcoma	30.2	MLANA, MDM2, TYR
27	li-fraumeni syndrome	30.1	MLH1, MDM2, TP53, PTEN
28	neuroectodermal tumors	29.9	VIM, MYC, S100A1, S100B, ATF1, MFI2
29	mesoblastic nephroma	29.8	IGF2, WT1
30	fibrous histiocytoma	29.7	VIM, S100B, ATF1, MITF, ACTC1, DES
31	rhabdoid tumors	29.4	VIM, IGF2, WT1, ACTC1, DES
32	vitiligo	29.4	MLANA, MLH1, MITF, TP53, PDGFRA, TYR
33	congenital mesoblastic nephroma	29.4	VIM, MDM2, IGF2, WT1
34	embryonal sarcoma	29.3	VIM, S100B, MKI67, MDM2, TP53, DES
35	basal cell carcinoma	29.2	MKI67, TP53, ACTC1, TYR
36	microphthalmia	29.0	S100B, MLANA, MITF, CREB1, ACTC1, TYR
37	spitz nevus	28.6	PCNA, BRAF, TP53
38	choroiditis	28.5	PCNA, VIM, BRAF, MYC, S100B, MKI67
39	renal cell carcinoma	28.3	PCNA, VIM, BRAF, S100A1, MKI67, MITF
40	pleomorphic adenoma	28.1	PCNA, VIM, S100A1, S100B, MDM2, IGF2
41	inflammatory myofibroblastic tumor	28.1	VIM, S100A1, MKI67, ACTC1, DES
42	kidney cancer	27.9	ENO2, TP53, PTEN, EGFR, DES
43	endometrial stromal nodule	27.8	VIM, DES
44	dermatofibrosarcoma protuberans	27.7	VIM, S100A1, S100B, ENO2, TP53, PDGFRA
45	liposarcoma	27.6	VIM, ATF1, MLH1, MDM2, EWSR1, TP53
46	vaccinia	27.5	S100A11, S100B, MDM2, TP53, EGFR, TYR
47	myxoid chondrosarcoma	27.4	VIM, S100A1, S100B, ENO2, EWSR1
48	lymphoblastic lymphoma	27.2	VIM, MYC, MLH1, MKI67, ENO2, TP53
49	neurofibromatosis	27.1	S100B, MLH1, ENO2, CREB1, PDGFRA
50	glioblastoma	27.0	MDM2, ERBB3, TP53, PTEN, PDGFRA, EGFR

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 aldesleukin, bleomycin, bleomycin sulfate, carmustine, dacarbazine, dactinomycin, docetaxel, doxorubicin hydrochloride, hydroxyurea, ifosfamide, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, lomustine, mitoxantrone, mitoxantrone hydrochloride, peginterferon alfa-2a, peginterferon alfa-2b, procarbazine, procarbazine hydrochloride, temozolomide, thiotepa

MalaCards organs/tissues related to clear cell sarcoma:

²²

MGI Mouse Phenotypes related to clear cell sarcoma:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	9.9	H19, TFE3, PDGFRA, MITF
2	endocrine/exocrine gland phenotype	MP:0005379	9.4	TYR, WT1, NRG1, EWSR1, MITF, LATS1
3	liver/biliary system phenotype	MP:0005370	9.0	TP53, EGFR, H19
4	reproductive system phenotype	MP:0005389	8.8	TYR, WT1, PDGFRA, NRG1, EWSR1, MLH1
5	limbs/digits/tail phenotype	MP:0005371	8.6	H19, TYR, EGFR, PDGFRA, IGF2, MDM2
6	renal/urinary system phenotype	MP:0005367	8.5	H19, TYR, EGFR, WT1, PDGFRA, PTEN
7	hematopoietic system phenotype	MP:0005397	8.2	HGF, TFE3, PDGFRA, EWSR1, IGF2, MDM2
8	normal phenotype	MP:0002873	8.0	H19, TFE3, TYR, WT1, PDGFRA, CREB1
9	immune system phenotype	MP:0005387	7.4	PDGFRA, WT1, EGFR, TYR, TFE3, DDIT3
10	embryogenesis phenotype	MP:0005380	7.2	CREB1, PDGFRA, EGFR, TYR, H19, NRG1
11	no phenotypic analysis	MP:0003012	7.1	H19, TYR, EGFR, TP53, IGF2, MITF
12	pigmentation phenotype	MP:0001186	7.1	TFE3, TYR, EGFR, PDGFRA, PTEN, TP53
13	behavior/neurological phenotype	MP:0005386	6.9	PTEN, DDIT3, NRG1, CREB1, PDGFRA, TYR
14	skeleton phenotype	MP:0005390	6.8	H19, TFE3, TYR, EGFR, PTEN, TP53
15	vision/eye phenotype	MP:0005391	6.6	EGFR, TYR, TFE3, H19, NRG1, PTEN
16	mortality/aging	MP:0010768	6.5	PDGFRA, EGFR, TYR, TFE3, DES, H19
17	tumorigenesis	MP:0002006	6.5	PTEN, PDGFRA, EGFR, TYR, H19, TP53
18	nervous system phenotype	MP:0003631	6.4	NRG1, CREB1, PDGFRA, EGFR, TYR, H19
19	digestive/alimentary phenotype	MP:0005381	6.4	H19, EGFR, PDGFRA, PTEN, TP53, ERBB3
20	integument phenotype	MP:0010771	5.4	TP53, PTEN, NRG1, PDGFRA, EGFR, TYR
21	muscle phenotype	MP:0005369	5.4	VIM, H19, DES, ACTC1, EGFR, WT1
22	growth/size phenotype	MP:0005378	4.8	CREB1, PDGFRA, WT1, EGFR, ACTC1, TYR
23	cardiovascular system phenotype	MP:0005385	4.7	CREB1, PDGFRA, WT1, EGFR, ACTC1, TYR
24	homeostasis/metabolism phenotype	MP:0005376	4.5	NRG1, CREB1, PDGFRA, WT1, EGFR, ACTC1
25	cellular phenotype	MP:0005384	3.8	DDIT3, NRG1, CREB1, PDGFRA, WT1, EGFR

Articles related to clear cell sarcoma:

(show all 44)

id	Title	Authors	Year	Affiliating Genes
1	Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma. (20068147)	Davis I.J.... Fisher D.E.	2010	HGF
2	Cutaneous clear cell sarcoma: a clinicopathologic, im munohistochemical, and molecular analysis of 12 cases emphasizing its distincti on from dermal melanoma. (20087159)	Hantschke M.... Kutzner H.	2010	ATF1, EWSR1
3	Primary giant clear cell sarcoma (soft tissue maligna nt melanoma) of the sternum. (19463625)	Rocco G.... Riva C.	2009	EWSR1
4	Clear cell sarcoma of the mediastinum. (19433300)	Tirabosco R.... Flanagan A.M.	2009	EWSR1
5	Detection and characterization of EWSR1/ATF1 and EWSR 1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts). (19561568)	Wang W.L.... LA^pez-Terrada D.	2009	CREB1, ATF1, EWSR1
6	Intestinal clear cell sarcoma with melanocytic differentiation and EWS [corrected] rearrangement: report of a case. (18417679)	Abdulkader I.... Forteza J.	2008	PDGFRA, TP53, VIM
7	Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases. (18300804)	Hisaoka M.... Hashimoto H.	2008	S100B
8	Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney. (17646270)	Little S.E.... Jones C.	2007	EGFR, PTEN
9	Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue. (16867224)	Schaefer K.L.... Poremba C.	2006	ERBB3, NRG1, ATF1
10	EWS-CREB1: a recurrent variant fusion in clear cell sarcoma--association with gastrointestinal location and absence of melanocytic differentiation. (17000668)	Antonescu C.R.... Ladanyi M.	2006	CREB1, ATF1, EWSR1
11	Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. (16766266)	Davis I.J.... Fisher D.E.	2006	MITF, TFE3, EWSR1
12	Clear cell sarcoma of tendons and aponeuroses: a historical perspective and tribute to the man behind the entity. (17075294)	Meis-Kindblom J.M.	2006	BRAF
13	Mismatch repair protein expression and microsatellite instability: a comparison of clear cell sarcoma of soft parts and metastatic melanoma. (16619000)	Garcia J.J.... Horvai A.E.	2006	MLH1
14	Absence of mutations of the BRAF gene in malignant melanoma of soft parts (clear cell sarcoma of tendons and aponeuroses). (15588860)	Panagopoulos I.... Mandahl N.	2005	BRAF
15	Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma. (16258500)	Patel R.M.... Skacel M.	2005	ATF1, EWSR1
16	Myxoid clear cell sarcoma. (15677980)	Kim Y.C.... Jung H.G.	2005	MLANA
17	Paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma. (15577676)	Deyrup A.T.... Weiss S.W.	2004	S100B, ACTC1
18	Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. (15150091)	Schaefer K.L.... Poremba C.	2004	ERBB3, S100B, ATF1
19	Cytogenetic comparison between clear cell sarcoma and a case of acral clear cell melanoma. (16285301)	Zelger B.G.... Zelger B.	2003	ATF1
20	Case report: case of clear cell sarcoma surviving with the primary lesion for 20 years after resection of a metastatic lymph node. (14666625)	Okamura N.... Uchida A.	2003	S100B
21	Classification of clear-cell sarcoma as a subtype of melanoma by genomic profiling. (12721254)	Segal N.H.... Houghton A.N.	2003	ATF1, EWSR1
22	Genetic and genetic expression analyses of clear cell sarcoma of the kidney. (13679437)	Schuster A.E.... Perlman E.J.	2003	IGF2, H19
23	Karyotypic divergence and convergence in two synchronous lung metastases of a clear cell sarcoma of tendons and aponeuroses with t(12;22)(q13;q12) and type 1 EWS/ATF1. (12935923)	Teixeira M.R.... Lopes C.	2003	ATF1, EWSR1
24	The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma. (12966428)	Li K.K.... Lee K.A.	2003	EWSR1
25	Functional and gene expression analysis of the p53 signaling pathway in clear cell sarcoma of the kidney and congenital mesoblastic nephroma. (12007018)	Brownlee N.A.... Re G.G.	2002	MDM2
26	Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene. (12072203)	Moritake H.... Kuroda H.	2002	MYC, MLANA
27	Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses. (11992546)	Panagopoulos I.... Mandahl N.	2002	ATF1, EWSR1
28	Clear cell sarcoma shows immunoreactivity for microphthalmia transcription factor: further evidence for melanocytic differentiation. (11211309)	Granter S.R.... Fisher D.E.	2001	S100B
29	Cerebellar metastasis from clear cell sarcoma of the kidney. A case report with immunohistochemistry. (11912476)	Dundar E.... Tel E.	2001	VIM, ENO2, DES
30	Tumor cell viability in clear cell sarcoma requires DNA binding activity of the EWS/ATF1 fusion protein. (10574952)	Bosilevac J.M.... Hinrichs S.H.	1999	ATF1, EWSR1
31	Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case. (10598869)	Cangul I.T.... Misdorp W.	1999	TYR
32	New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts). (9824209)	Pellin A.... Llombart-Bosch A.	1998	ATF1, EWSR1
33	Clear cell sarcoma of soft tissues. Clinico-pathological and ultrastructural analysis of a case in the head-neck region and a literature review (9793401)	Bisceglia M.... Martinelli G.N.	1998	VIM
34	Malignant melanoma of soft parts (clear cell sarcoma)--a rare case of multiorgan localization (9729915)	Kothaj P.... Okapec S.	1998	DES
35	Insulin-like growth factor 2 gene imprinting in clear cell sarcoma of the kidney. (9385942)	Sohda T.... Yun K.	1997	IGF2
36	Intracranial metastasis from clear cell sarcoma of the kidney--a case report. (9364310)	Park D.Y.... Chi J.G.	1997	PCNA
37	Malignant melanoma of the soft parts (clear-cell sarcoma): confirmation of EWS and ATF-1 gene fusion caused by a t(12;22) translocation. (9160316)	Speleman F.... Van Marck E.	1997	ATF1, EWSR1
38	Primary malignant melanoma (clear cell sarcoma) of bone: report of a case arising in the ulna. (8640695)	Yokoyama R.... Fukuma H.	1996	LINC00328
39	Newly established MST-1 tumour cell line and tumour-infiltrating lymphocyte culture from a patient with soft tissue melanoma (clear cell sarcoma) and their potential applications to patient immunotherapy. (8664053)	Liao S.K.... Ho Y.S.	1996	MFI2
40	The 12q13-q15 translocation breakpoints in pleomorphic adenoma and clear-cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma. (7687873)	Stenman G.... Aman P.	1993	DDIT3
41	Clear cell sarcoma of the kidney expresses insulinlike growth factor-II but not WT1 transcripts. (8424465)	Yun K.	1993	WT1
42	Clear cell sarcoma of the kidney in a 4-month-old infant: a case report. (8341222)	Newbould M.J.... Kelsey A.M.	1993	VIM
43	Clear cell sarcoma of kidney. Two cases in adults. (8453549)	Oda H.... Machinami R.	1993	S100A1
44	Clear cell sarcomas and metastatic soft tissue melanomas. A flow cytometric comparison and prognostic implications. (2004337)	El-Naggar A.K.... Batsakis J.G.	1991	S100B

Genes related to clear cell sarcoma according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	ATF1	activating transcription factor 1	11.1	Publications, Summaries
2	LINC00328	long intergenic non-protein coding RNA 328	11.0	Publications
3	EWSR1	Ewing sarcoma breakpoint region 1	11.0	Publications
4	CCDC65	coiled-coil domain containing 65	11.0
5	S100A11	S100 calcium binding protein A11	11.0	Publications
6	KCTD12	potassium channel tetramerisation domain containing 12	11.0	Disorders
7	MLANA	melan-A	11.0	Publications
8	TFE3	transcription factor binding to IGHM enhancer 3	11.0	Publications
9	MFI2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	11.0	Publications
10	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0	Publications
11	ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	11.0	Publications
12	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
13	DDIT3	DNA-damage-inducible transcript 3	11.0	Publications
14	S100A1	S100 calcium binding protein A1	11.0	Publications
15	S100B	S100 calcium binding protein B	11.0	Publications
16	LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	11.0
17	DES	desmin	11.0	Publications
18	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
19	VIM	vimentin	11.0	Publications
20	MITF	microphthalmia-associated transcription factor	11.0	Publications
21	WT1	Wilms tumor 1	11.0	Publications
22	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
23	PTEN	phosphatase and tensin homolog	11.0	Publications
24	TYR	tyrosinase (oculocutaneous albinism IA)	11.0	Publications
25	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
26	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
27	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
28	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
29	CREB1	cAMP responsive element binding protein 1	11.0	Publications
30	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
31	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
32	NRG1	neuregulin 1	11.0	Publications
33	PCNA	proliferating cell nuclear antigen	11.0	Publications
34	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
35	TP53	tumor protein p53	11.0	Publications
36	EGFR	epidermal growth factor receptor	11.0	Publications

Pathways related to clear cell sarcoma according to GeneDecks:

(show top 50)    (show all 89)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.3	PCNA
2	ErbB2-ErbB3 Heterodimers36	10.2	NRG1, ERBB3
3	14-3-3 Induced Intracellular Signaling36	10.0	NRG1, PDGFRA, ERBB3
4	DNA damage ATM/ATR regulation of G1/S checkpoint10	9.7	MYC, MDM2
5	Pathway_PA16598005034	9.7	MYC, BRAF, PDGFRA
6	Akt Signaling36	9.5	ERBB3, NRG1, HGF, PDGFRA, MDM2
7	Breast Cancer Regulation by Stathmin136	9.4	NRG1, ERBB3, HGF, EGFR
8	JNK Pathway36	9.2	PDGFRA, NRG1, TP53
9	Ras Pathway36	9.1	ERBB3, IGF2, NRG1, EGFR, BRAF
10	Development_Thrombopoietin-regulated cell processes41	9.0	BRAF, MYC, CREB1, ATF1
11	DNA damage Role of Brca1 and Brca2 in DNA repair10	8.9	TP53, PCNA, MLH1, ATF1
12	DNA damage_Role of Brca1 and Brca2 in DNA repair41	8.9	MLH1, ATF1, TP53, PCNA
13	Activation of cAMP-Dependent PKA36	8.9	ATF1, IGF2, ERBB3, NRG1, CREB1, HGF
14	Development Thrombopoietin-regulated cell processes10	8.8	ATF1, MYC, BRAF, CREB1
15	Rho Family GTPases36	8.8	DES, ERBB3, HGF, VIM, IGF2, NRG1
16	ErbB signaling pathway20	8.7	EGFR, NRG1, ERBB3, BRAF, MYC
17	Activation of PKA through GPCR36	8.7	PDGFRA, HGF, CREB1, NRG1, ERBB3, IGF2
18	P2Y Receptor Signaling36	8.7	MYC, BRAF, EGFR, PDGFRA, CREB1, ERBB3
19	ILK Signaling36	8.6	VIM, ATF1, IGF2, ERBB3, NRG1, CREB1
20	Nanog in Mammalian ESC Pluripotency36	8.6	HGF, EGFR, PDGFRA, NRG1, ERBB3, IGF2
21	eIF2 Pathway36	8.6	NRG1, EGFR, PDGFRA, HGF, BRAF, IGF2
22	Rap1 Pathway36	8.5	IGF2, ERBB3, NRG1, PDGFRA, EGFR, HGF
23	Glioma20	8.5	BRAF, MDM2, TP53, PDGFRA, EGFR, PTEN
24	Signal transduction PTEN pathway10	8.5	PCNA, EGFR, TP53, PTEN, MDM2
25	Nuclear Receptor Activation by Vitamin-A36	8.4	IGF2, NRG1, CREB1, PDGFRA, EGFR, HGF
26	Bladder cancer20	8.4	TP53, BRAF, MYC, MDM2, EGFR
27	Signal transduction_AKT signaling41	8.3	TP53, MDM2, MYC, PCNA, PTEN
28	DNA damage_ATM/ATR regulation of G1/S checkpoint41	8.3	TP53, PCNA, MYC, MDM2
29	Estrogen Pathway36	8.3	HGF, CREB1, NRG1, ERBB3, IGF2, EGFR
30	GPCR Pathway36	8.3	IGF2, ERBB3, NRG1, CREB1, EGFR, HGF
31	Glioblastoma Multiforme36	8.3	EGFR, PDGFRA, PTEN, TP53, BRAF, MDM2
32	Prostate cancer20	8.2	PDGFRA, MDM2, EGFR, PTEN, TP53, BRAF
33	Apoptotic Pathways in Synovial Fibroblasts36	8.2	HGF, EGFR, PDGFRA, NRG1, TP53, IGF2
34	Intracellular Calcium Signaling36	8.1	IGF2, ERBB3, NRG1, CREB1, EGFR, HGF
35	cAMP Pathway36	8.1	KCTD12, ATF1, BRAF, PDGFRA, IGF2, HGF
36	ERK5 Signaling36	8.1	MYC, EGFR, PDGFRA, HGF, NRG1, IGF2
37	Melanoma20	8.0	PTEN, MITF, HGF, EGFR, PDGFRA, TP53
38	Endometrial cancer20	8.0	BRAF, TP53, EGFR, MLH1, PTEN, MYC
39	Mitochondrial Apoptosis36	7.9	PDGFRA, IGF2, HGF, NRG1, TP53, MDM2
40	Cellular Apoptosis Pathway36	7.9	HGF, NRG1, EGFR, IGF2, TP53, PDGFRA
41	JAK-STAT Pathway36	7.9	ERBB3, IGF2, EGFR, HGF, MYC, PDGFRA
42	PTEN Pathway36	7.8	PTEN, NRG1, BRAF, MDM2, TP53, PDGFRA
43	p53 Mediated Apoptosis36	7.7	NRG1, PDGFRA, EGFR, HGF, IGF2, MDM2
44	Pathways in cancer20	7.7	MITF, MYC, PTEN, PDGFRA, TP53, MDM2
45	Telomerase Components in Cell Signaling36	7.6	PDGFRA, NRG1, TP53, EGFR, MYC, HGF
46	p38 Signaling36	7.6	IGF2, ERBB3, TP53, CREB1, NRG1, HGF
47	Pancreatic Adenocarcinoma36	7.6	BRAF, NRG1, TP53, ERBB3, IGF2, EGFR
48	Molecular Mechanisms of Cancer36	6.9	IGF2, MDM2, EGFR, PDGFRA, NRG1, MYC
49	ERK Signaling36	6.8	ATF1, MYC, BRAF, ERBB3, TP53, NRG1
50	MAPK Signaling36	6.6	DDIT3, NRG1, CREB1, PDGFRA, EGFR, HGF

Compounds related to clear cell sarcoma according to GeneDecks:

(show top 50)    (show all 182)

id	Compound	Score	Top Affiliating Genes
1	ly29400232	10.2	NRG1, TYR
2	s 10032	9.9	VIM, S100B, ENO2, ACTC1, DES
3	threonine32	9.8	LATS1, NRG1, WT1
4	h2o232	9.8	DDIT3, DES, CREB1, TYR
5	mucicarmine32	9.5	VIM, S100B, ACTC1, S100A1, DES
6	agar32	9.4	H19, NRG1, ERBB3, IGF2, BRAF, VIM
7	reticulin32	9.4	PCNA, VIM, S100B, ACTC1, DES
8	b 72332	9.2	VIM, S100A1, PCNA, WT1, S100B, DES
9	rapamycin32 42	9.9	EGFR, PDGFRA, ERBB3, IGF2, VIM, MDM2
10	12-o-tetradecanoylphorbol 13-acetate32	8.8	CREB1, MITF, NRG1, BRAF, MYC, ATF1
11	hematoxylin32	8.6	VIM, S100A1, S100B, MLANA, MKI67, ENO2
12	formaldehyde32 18	9.5	PCNA, DES, TYR, ACTC1, ENO2, VIM
13	arginine32	8.5	IGF2, EWSR1, MDM2, MITF, MLH1, S100B
14	gefitinib32 34 9 9	11.4	HGF, EGFR, PTEN, ERBB3, IGF2, MDM2
15	estradiol32 9 18 9	11.2	DES, CREB1, PTEN, ERBB3, MDM2, MKI67
16	oxygen32 18	9.1	NRG1, ACTC1, MLH1, PTEN, MDM2, MFI2
17	azathioprine32 34 9 9	11.1	H19, DES, CREB1, MLH1, VIM, PCNA
18	forskolin32 42 9 9	11.1	WT1, CREB1, NRG1, ERBB3, VIM, S100B
19	carboplatin32 34 9 9	11.0	TP53, ENO2, EGFR, DDIT3, MDM2, MLH1
20	mg 13232 42	9.0	HGF, DDIT3, PTEN, MDM2, EGFR, PCNA
21	irinotecan32 34 9 9	10.8	EGFR, TP53, IGF2, MDM2, BRAF, MKI67
22	leucine32	7.8	PTEN, DDIT3, TFE3, CREB1, NRG1, VIM
23	progesterone32 42 9 18 9	11.8	WT1, NRG1, PTEN, ERBB3, ATF1, S100B
24	imatinib32 34 9 9	10.4	WT1, EGFR, ACTC1, DES, HGF, PDGFRA
25	pd 98,05932	7.4	CREB1, MYC, BRAF, MDM2, ENO2, PTEN
26	glycogen32 18	8.3	MYC, VIM, HGF, DES, ACTC1, CREB1
27	5-aza-2deoxycytidine32	7.3	TP53, IGF2, PTEN, PCNA, MDM2, MLH1
28	bromodeoxyuridine32	7.3	MYC, VIM, PCNA, MLH1, S100B, MKI67
29	proline32	7.2	MDM2, S100B, MLH1, HGF, DES, TFE3
30	genistein32 9 18 9	10.2	HGF, PCNA, EGFR, TYR, CREB1, DDIT3
31	steroid32	7.2	WT1, S100B, IGF2, MLANA, MLH1, ERBB3
32	retinoic acid32 42 18	9.0	EWSR1, DDIT3, NRG1, PDGFRA, WT1, TYR
33	estrogen32	7.0	ERBB3, IGF2, MKI67, MLH1, S100B, S100A1
34	5fluorouracil32	7.0	PCNA, MLH1, MKI67, MDM2, HGF, TP53
35	actinomycin d32	7.0	DDIT3, NRG1, CREB1, DES, TP53, VIM
36	etoposide32 42 9 9	9.8	HGF, CREB1, DDIT3, PTEN, TP53, ENO2
37	calcium32 9 18 9	9.7	S100A1, MLH1, MKI67, MDM2, EWSR1, ERBB3
38	tamoxifen32 34 9 9	9.6	EGFR, NRG1, PTEN, IGF2, TP53, VIM
39	alanine32	6.4	ENO2, PCNA, VIM, BRAF, MYC, S100B
40	cycloheximide32	5.9	TYR, MKI67, MDM2, IGF2, TP53, DDIT3
41	doxorubicin32 34 9 9	8.8	HGF, DES, TYR, EGFR, WT1, NRG1
42	testosterone32 9 18 9	8.8	IGF2, ERBB3, PTEN, DDIT3, NRG1, CREB1
43	oligonucleotide32	5.8	VIM, MITF, PCNA, BRAF, PDGFRA, CREB1
44	thymidine32 18	6.6	PCNA, MYC, S100B, MLH1, MKI67, MDM2
45	cisplatin32 34 9 9	8.2	DDIT3, NRG1, EGFR, TYR, HGF, PCNA
46	paclitaxel32 34 9 9	8.0	PTEN, DDIT3, EGFR, PCNA, VIM, BRAF
47	serine32	4.7	WT1, HGF, DES, TYR, TP53, PTEN
48	tyrosine32	4.4	NRG1, HGF, DDIT3, H19, DES, TYR
49	vegf32	3.5	ENO2, MDM2, MKI67, MLH1, S100B, MYC
50	paraffin32	3.2	BRAF, VIM, PCNA, MYC, ACTC1, EGFR

Cellular components related to clear cell sarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear body	GO:016604	8.4	TP53, MDM2, MYC
2	protein complex	GO:043234	8.4	MYC, S100A1, MITF, MDM2, TP53
3	cytoplasm	GO:005737	4.4	PCNA, DDIT3, NRG1, PDGFRA, WT1, EGFR
4	nucleus	GO:005634	3.9	ERBB3, TP53, PTEN, NRG1, CREB1, PDGFRA

Biological processes related to clear cell sarcoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of secretion	GO:051048	10.0	ERBB3, NRG1
2	muscle filament sliding	GO:030049	9.8	DES, ACTC1, VIM
3	positive regulation of DNA replication	GO:045740	9.6	ATF1, PDGFRA, EGFR
4	nerve growth factor receptor signaling pathway	GO:048011	9.3	CREB1, PTEN, MDM2, ATF1, BRAF
5	positive regulation of fibroblast proliferation	GO:048146	9.1	MYC, PDGFRA, EGFR
6	phosphatidylinositol-mediated signaling	GO:048015	9.1	PDGFRA, CREB1, PTEN, MDM2, PCNA
7	response to drug	GO:042493	9.0	ACTC1, CREB1, DDIT3, ERBB3, ENO2, MYC
8	positive regulation of cell proliferation	GO:008284	8.4	EGFR, PDGFRA, PTEN, IGF2, MDM2, MYC
9	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.8	TFE3, CREB1, DDIT3, TP53, MITF, ATF1
10	negative regulation of apoptotic process	GO:043066	7.7	EGFR, WT1, PTEN, TP53, MDM2, MYC
11	cell proliferation	GO:008283	7.4	PCNA, TYR, EGFR, NRG1, PTEN, TP53

Molecular functions related to clear cell sarcoma according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	S100 protein binding	GO:044548	10.1	S100B, S100A11, S100A1
2	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.6	ERBB3, PDGFRA, EGFR
3	protein homodimerization activity	GO:042803	8.9	TYR, PDGFRA, ERBB3, ENO2, S100B, S100A11
4	double-stranded DNA binding	GO:003690	8.7	EGFR, WT1, CREB1, MYC
5	identical protein binding	GO:042802	7.8	EGFR, TP53, MDM2, S100B, S100A1, VIM
6	protein heterodimerization activity	GO:046982	7.3	HGF, TYR, EGFR, TP53, ERBB3, ENO2
7	protein binding	GO:005515	2.6	PCNA, EWSR1, ERBB3, TP53, PTEN, NRG1