MCID: CLR017
MIFTS: 52

Clear Cell Sarcoma malady

Cancer diseases category

Summaries for Clear Cell Sarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. it presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

MalaCards: Clear Cell Sarcoma, also known as melanoma, malignant, of soft parts, is related to sarcoma and melanoma. An important gene associated with Clear Cell Sarcoma is ATF1 (activating transcription factor 1), and among its related pathways are RSK activation and Striated Muscle Contraction. The compounds glycogen and creatinine have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and lymph node, and related mouse phenotypes are muscle and normal.

Wikipedia:63 Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer... more...

Aliases & Classifications for Clear Cell Sarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

clear cell sarcoma 8 10
melanoma, malignant, of soft parts 8
adult soft part clear cell sarcoma 8
malignant melanoma of soft tissues 8
clear cell sarcoma of soft parts 8
sarcoma, clear cell 60
sarcoma clear cell 44


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Disease Ontology8 DOID:4233
NCIt39 C3745
MeSH34 D018227

Related Diseases for Clear Cell Sarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Clear Cell Sarcoma family:

Small Cell Sarcoma

Diseases related to Clear Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.0ENO2, VIM, S100B, S100A1, EWSR1, TFE3
2melanoma31.4VIM, S100B, S100A1, EWSR1, MFI2, CREB1
3spindle cell sarcoma30.5VIM, S100B, DES, ACTC1
4synovial sarcoma30.3VIM, S100B, DES
5adenoma30.3S100A1, H19, CREB1, ACTC1, ENO2
6alveolar soft part sarcoma30.1TFE3
7neuroblastoma30.1ENO2
8myxoid liposarcoma30.1ATF1, DDIT3, EWSR1
9paraganglioma30.1ENO2, S100A1, S100B
10osteosarcoma30.1DDIT3, CREB1, H19
11liposarcoma30.1VIM, EWSR1, DDIT3, DES
12giant cell tumor30.1VIM, S100B, DES, ACTC1
13malignant mesothelioma30.1VIM, S100A1, DES
14pleomorphic adenoma30.1VIM, S100B, S100A1, DES, ACTC1
15microphthalmia30.1S100B, TFE3, CREB1, MLANA, ACTC1
16chondrosarcoma30.1VIM, S100B, S100A1, EWSR1, DDIT3, DES
17rhabdomyosarcoma30.1VIM, S100B, S100A1, H19, EWSR1, DDIT3
18kidney clear cell sarcoma11.1
19kidney sarcoma11.1
20small cell sarcoma10.4
21epithelioid sarcoma10.3
22tendinitis10.2
23clear cell adenoma10.2
24brain sarcoma10.2
25sarcomatosis10.2
26lung sarcoma10.2
27peritonitis10.2
28melanoma of soft part10.2
29choroiditis10.1
30amelanotic melanoma10.1
31familial adenomatous polyposis10.1
32pleomorphic liposarcoma10.1
33familial melanoma10.1
34epithelioid cell synovial sarcoma10.1
35penis sarcoma10.1
36metanephric adenoma10.1
37acral lentiginous melanoma10.1
38gastroduodenitis10.1
39pediatric lymphoma10.1
40clear cell chondrosarcoma10.1
41arthritis10.1
42colon sarcoma10.1
43congenital mesoblastic nephroma10.1
44kidney disease10.1
45malignant pleural mesothelioma10.1
46mediastinum sarcoma10.1
47neuroma10.1
48ovary sarcoma10.1
49pericardial effusion10.1
50pulmonary embolism10.1

Graphical network of the top 20 diseases related to Clear Cell Sarcoma:



Diseases related to clear cell sarcoma

Clinical Features for Clear Cell Sarcoma

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Drugs & Therapeutics for Clear Cell Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Clear Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Clear Cell Sarcoma

Search NIH Clinical Center for Clear Cell Sarcoma

Search CenterWatch for Clear Cell Sarcoma

Genetic Tests for Clear Cell Sarcoma

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Anatomical Context for Clear Cell Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Clear Cell Sarcoma:

32
Kidney, Bone, Lymph node, Tongue, Brain, Lung, Small intestine, Colon, Skin, Ovary

Animal Models for Clear Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Clear Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0ERBB3, ACTC1, CREB1, H19
2MP:00028739.1ERBB3, S100B, S100A1, H19, EWSR1, TFE3

Publications for Clear Cell Sarcoma

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50PubMed
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Articles related to Clear Cell Sarcoma:

(show top 50)    (show all 371)
idTitleAuthorsYear
1
Clear cell sarcoma of the tongue. (24117610)
2013
2
Clear cell sarcoma of the jaw: a case report and review of the literature. (22858566)
2013
3
A rare case of clear cell sarcoma with 4 types of EWSR1-ATF1 fusions detected not in primary site but in metastatic site. (23953591)
2013
4
Two cases of clear cell sarcoma with different clinical and genetic features: cutaneous type with BRAF mutation and subcutaneous type with KIT mutation. (23796270)
2013
5
Clear cell sarcoma (malignant melanoma) of soft parts: a clinicopathologic study of 52 cases. (22693489)
2012
6
Clear cell sarcoma of the ankle. (22880526)
2012
7
Chemotherapy in clear cell sarcoma. (20390470)
2011
8
Cutaneous clear cell sarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma. (20087159)
2010
9
Diagnostic utility of EWS break-apart fluorescence in situ hybridization in distinguishing between non-cutaneous melanoma and clear cell sarcoma. (20712646)
2010
10
Primary giant clear cell sarcoma (soft tissue malignant melanoma) of the sternum. (19463625)
2009
11
Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumour. (17681013)
2008
12
Osteoclast-rich tumor of the gastrointestinal tract with features resembling those of clear cell sarcoma of soft parts. (16220298)
2006
13
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. (16766266)
2006
14
Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report. (17341045)
2006
15
Clear cell sarcoma of tendons and aponeuroses: a historical perspective and tribute to the man behind the entity. (17075294)
2006
16
Primary clear cell sarcoma of rib. (15592669)
2005
17
Clear cell sarcoma (malignant melanoma of soft parts) and sentinel lymph node biopsy. (15701594)
2005
18
Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. (15474157)
2004
19
Pathologic quiz case: a 50-year-old man with a lung mass, respiratory distress, and pericardial effusion. Metastatic clear cell sarcoma (malignant melanoma of soft parts). (14987129)
2004
20
Case report: case of clear cell sarcoma surviving with the primary lesion for 20 years after resection of a metastatic lymph node. (14666625)
2003
21
Fine needle aspiration cytology of clear cell sarcoma of the kidney with spindle cell pattern. (12828728)
2003
22
Clear cell sarcoma of the kidney in a newborn. (12825224)
2003
23
Establishment and characterisation of a human clear cell sarcoma model in nude mice. (12237889)
2002
24
Clear cell sarcoma of tendons and aponeuroses in pediatric patients: a report from the Italian and German Soft Tissue Sarcoma Cooperative Group. (12115360)
2002
25
Clear cell sarcoma shows immunoreactivity for microphthalmia transcription factor: further evidence for melanocytic differentiation. (11211309)
2001
26
Clear cell sarcoma of soft parts. A case report and review of the literature. (11398297)
2001
27
Ovarian sarcoma with pathologic features of clear cell sarcoma of the kidney. (10890934)
2000
28
Soft tissue Ewing sarcoma--peripheral primitive neuroectodermal tumor with atypical clear cell pattern shows a new type of EWS-FEV fusion transcript. (10976720)
2000
29
Clear cell sarcoma kidney: clinical features and outcome. (10100278)
1999
30
Clear cell sarcoma of the kidney: an unusual presentation and review of the literature. (9544171)
1998
31
Clear cell sarcoma: an extremely rare cause of pleural disease. (9426110)
1997
32
Dramatic response to ifosfamide, mesna and doxorubicin chemotherapy regimen in an adult with clear cell sarcoma of the kidney. (8618315)
1996
33
Newly established MST-1 tumour cell line and tumour-infiltrating lymphocyte culture from a patient with soft tissue melanoma (clear cell sarcoma) and their potential applications to patient immunotherapy. (8664053)
1996
34
Aberrations of chromosome 22 and polysomy of chromosome 8 as non-random changes in clear cell sarcoma. (8143273)
1994
35
Treatment of children with clear-cell sarcoma of the kidney: a report from the National Wilms' Tumor Study Group. (7931484)
1994
36
Clear cell sarcoma (malignant melanoma of soft parts). Presentation of two additional cases. (8491327)
1993
37
Clear cell sarcoma of tendons and aponeuroses and malignant blue nevus arising in prepubescent children. Report of two cases and review of the literature. (8494114)
1993
38
Clear cell sarcoma of the kidney in a 4-month-old infant: a case report. (8341222)
1993
39
Round cell sarcoma after clear cell sarcoma remission. (1835638)
1991
40
Cytogenetic findings in clear cell sarcoma of tendons and aponeuroses. Malignant melanoma of soft parts. (2009504)
1991
41
Chromosomal abnormalities in clear cell sarcoma. Implications for histogenesis. (2294702)
1990
42
Case report 423: Clear-cell sarcoma plantar aspect of right foot. (3616672)
1987
43
Sarcomas--a clinicopathological guide with special reference to cutaneous manifestation. IV. Extraskeletal osteosarcoma, extraskeletal chondrosarcoma, alveolar soft part sarcoma, clear cell sarcoma and discussion. (3912082)
1985
44
Premelanosomes in clear cell sarcoma. (6546501)
1984
45
Clear cell sarcoma of tendons and aponeuroses. A review and case report. (11064711)
1984
46
Clear cell sarcoma. A clinicopathologic study of 27 cases. (6616410)
1983
47
Clear-cell sarcoma with melanin pigment: a possible soft-tissue variant of malignant melanoma. Case report. (422614)
1979
48
Clear cell sarcoma with melanin: report of two cases. (626932)
1978
49
Clear-cell sarcoma of palmar aponeurosis and tendons. (977056)
1976
50
Clear-cell sarcoma of tendons. A study of 4 cases. (4315730)
1969

Genetic Variations for Clear Cell Sarcoma

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Expression for genes affiliated with Clear Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Sarcoma

Search GEO for disease gene expression data for Clear Cell Sarcoma.

Pathways for genes affiliated with Clear Cell Sarcoma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ATF1, CREB1
2
Hide members
10.1VIM, DES, ACTC1
310.1ATF1, DDIT3, CREB1
49.9ATF1, DDIT3, TFE3, EWSR1
5
Hide members
9.7ERBB3, DES, ATF1, DDIT3, CREB1, VIM

Compounds for genes affiliated with Clear Cell Sarcoma

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44Novoseek, 24HMDB, 49PharmGKB, 2BitterDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1glycogen44 2411.6ACTC1, CREB1
2creatinine4410.6ACTC1
3askin4410.5EWSR1, ENO2
42-methoxyethanol4410.5ACTC1, S100A1, VIM
5orcein4410.4VIM, ACTC1, DES, S100B
6edss4410.4S100B, ENO2
7reticulin4410.4DES, ACTC1, S100B, VIM
8eosin4410.4VIM, S100B
9actomyosin4410.4ACTC1, VIM, S100A1
10azathioprine44 49 2 1113.3CREB1, H19, VIM, DES
11toluidine4410.3ENO2, DES, S100A1, VIM
12acetylcholine44 49 28 11 2414.3ERBB3, S100A1, ENO2, CREB1
13glucose4410.3ERBB3, ACTC1, DDIT3, TFE3
14mucicarmine4410.3S100B, VIM, ACTC1, DES, S100A1
15dbc-amp4410.3VIM, S100B, ENO2, CREB1
16b 7234410.3VIM, S100B, S100A1, DES, ACTC1
17biotin44 11 2412.3S100A1, DES, ACTC1, VIM
18s 1004410.2VIM, S100B, DES, ACTC1, ENO2
19glutamine4410.2ENO2, DDIT3, CREB1, EWSR1
20agar4410.2CREB1, ERBB3, H19, VIM
21formaldehyde44 2411.2VIM, S100B, DES, ENO2, ACTC1
22acth4410.2ENO2, S100B, CREB1, H19
23ganglioside4410.1ENO2, VIM, DES
24bromodeoxyuridine4410.1S100B, DDIT3, ENO2, VIM, DES
25norepinephrine44 11 2412.1CREB1, S100B, ATF1, ENO2, DES
26gaba4410.1CREB1, S100B, ENO2, VIM
27cyclic amp44 2411.1CREB1, ATF1, EWSR1, S100B, DES, VIM
28etoposide44 49 59 1113.1VIM, ENO2, S100B, DDIT3, CREB1
29forskolin44 49 1112.1ATF1, CREB1, VIM, S100B, ENO2, ERBB3
30adenylate4410.0VIM, DES, CREB1, ENO2, ATF1, S100B
31steroid4410.0ERBB3, DES, ATF1, CREB1, H19, ACTC1
32lactate4410.0ENO2, DES, MLANA, CREB1, S100B, VIM
33zinc44 2411.0S100A1, CREB1, MFI2, EWSR1, H19, S100B
3412-o-tetradecanoylphorbol 13-acetate4410.0VIM, ATF1, DES, CREB1
35heparin44 28 11 2413.0ERBB3, ENO2, DES, S100B, VIM
36hematoxylin449.9MLANA, DES, ACTC1, VIM, S100A1, S100B
37methionine449.9DES, S100B, VIM, DDIT3
38leucine449.9VIM, ENO2, ATF1, DDIT3, CREB1, TFE3
39progesterone44 59 28 11 2413.8VIM, S100A1, S100B, ATF1, DES, ACTC1
40sb 20358044 5910.8ATF1, DDIT3, CREB1, VIM
41testosterone44 59 11 2412.8CREB1, ERBB3, DES, S100B, VIM, ACTC1
42iron44 2410.8DES, ACTC1, DDIT3, S100A1, S100B, VIM
43vegf449.8DDIT3, DES, VIM, ENO2, ERBB3, ACTC1
44atp44 2810.7DDIT3, CREB1, S100B, ENO2, S100A11, VIM
45silver449.7S100A1, ENO2, DES
46oxygen44 2410.7DES, S100B, ENO2, ACTC1, MFI2, DDIT3
47paraffin449.6H19, VIM, S100B, S100A1, EWSR1, MLANA
48retinoic acid44 2410.5CREB1, EWSR1, S100B, S100A1, H19, DDIT3
49tyrosine449.5ENO2, ERBB3, ACTC1, DES, DDIT3, CREB1
50calcium44 49 11 2412.3S100A11, DES, ENO2, ERBB3, ATF1, DDIT3

GO Terms for genes affiliated with Clear Cell Sarcoma

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16Gene Ontology
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Biological processes related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.1ACTC1, DES, VIM

Molecular functions related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.9S100A11, S100A1, S100B
2identical protein bindingGO:0428029.4VIM, S100B, S100A1, EWSR1, DES, ERBB3
3protein bindingGO:0055158.7S100B, S100A1, S100A11, EWSR1, MFI2, CREB1

Products for genes affiliated with Clear Cell Sarcoma

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Sources for Clear Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet