MCID: CLR017
MIFTS: 52

Clear Cell Sarcoma malady

Cancer diseases category

Summaries for Clear Cell Sarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. it presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

MalaCards: Clear Cell Sarcoma, also known as melanoma, malignant, of soft parts, is related to sarcoma and melanoma. An important gene associated with Clear Cell Sarcoma is ATF1 (activating transcription factor 1), and among its related pathways are RSK activation and Striated Muscle Contraction. The compounds glycogen and creatinine have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and lymph node, and related mouse phenotypes are muscle and normal.

Wikipedia:63 Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer... more...

Aliases & Classifications for Clear Cell Sarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

clear cell sarcoma 8 10
melanoma, malignant, of soft parts 8
adult soft part clear cell sarcoma 8
malignant melanoma of soft tissues 8
clear cell sarcoma of soft parts 8
sarcoma, clear cell 60
sarcoma clear cell 44


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Disease Ontology8 DOID:4233
NCIt39 C3745
MeSH34 D018227

Related Diseases for Clear Cell Sarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Clear Cell Sarcoma family:

Small Cell Sarcoma

Diseases related to Clear Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.0ENO2, VIM, S100B, S100A1, EWSR1, TFE3
2melanoma31.4VIM, S100B, S100A1, EWSR1, MFI2, CREB1
3spindle cell sarcoma30.5VIM, S100B, DES, ACTC1
4synovial sarcoma30.3VIM, S100B, DES
5adenoma30.3S100A1, H19, CREB1, ACTC1, ENO2
6alveolar soft part sarcoma30.1TFE3
7neuroblastoma30.1ENO2
8myxoid liposarcoma30.1ATF1, DDIT3, EWSR1
9paraganglioma30.1ENO2, S100A1, S100B
10osteosarcoma30.1DDIT3, CREB1, H19
11liposarcoma30.1VIM, EWSR1, DDIT3, DES
12giant cell tumor30.1VIM, S100B, DES, ACTC1
13malignant mesothelioma30.1VIM, S100A1, DES
14pleomorphic adenoma30.1VIM, S100B, S100A1, DES, ACTC1
15microphthalmia30.1S100B, TFE3, CREB1, MLANA, ACTC1
16chondrosarcoma30.1VIM, S100B, S100A1, EWSR1, DDIT3, DES
17rhabdomyosarcoma30.1VIM, S100B, S100A1, H19, EWSR1, DDIT3
18kidney clear cell sarcoma11.1
19kidney sarcoma11.1
20small cell sarcoma10.4
21epithelioid sarcoma10.3
22tendinitis10.2
23clear cell adenoma10.2
24brain sarcoma10.2
25sarcomatosis10.2
26lung sarcoma10.2
27peritonitis10.2
28melanoma of soft part10.2
29choroiditis10.1
30amelanotic melanoma10.1
31familial adenomatous polyposis10.1
32pleomorphic liposarcoma10.1
33familial melanoma10.1
34epithelioid cell synovial sarcoma10.1
35penis sarcoma10.1
36metanephric adenoma10.1
37acral lentiginous melanoma10.1
38gastroduodenitis10.1
39pediatric lymphoma10.1
40clear cell chondrosarcoma10.1
41arthritis10.1
42colon sarcoma10.1
43congenital mesoblastic nephroma10.1
44kidney disease10.1
45malignant pleural mesothelioma10.1
46mediastinum sarcoma10.1
47neuroma10.1
48ovary sarcoma10.1
49pericardial effusion10.1
50pulmonary embolism10.1

Graphical network of the top 20 diseases related to Clear Cell Sarcoma:



Diseases related to clear cell sarcoma

Clinical Features for Clear Cell Sarcoma

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Drugs & Therapeutics for Clear Cell Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Clear Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Clear Cell Sarcoma

Search NIH Clinical Center for Clear Cell Sarcoma

Search CenterWatch for Clear Cell Sarcoma

Genetic Tests for Clear Cell Sarcoma

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Anatomical Context for Clear Cell Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Clear Cell Sarcoma:

32
Kidney, Bone, Lymph node, Tongue, Brain, Lung, Small intestine, Colon, Skin, Ovary

Animal Models for Clear Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Clear Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0ERBB3, ACTC1, CREB1, H19
2MP:00028739.1ERBB3, S100B, S100A1, H19, EWSR1, TFE3

Publications for Clear Cell Sarcoma

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50PubMed
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Articles related to Clear Cell Sarcoma:

(show top 50)    (show all 371)
idTitleAuthorsYear
1
Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model. (24389062)
2013
2
DNA methylation profile distinguishes clear cell sarcoma of the kidney from other pediatric renal tumors. (23638012)
2013
3
Caffeine-potentiated chemotherapy for clear cell sarcoma: a report of five cases. (22041928)
2013
4
Spinal anaesthesia for caesarean section in the presence of respiratory failure and spinal metastases from a soft tissue clear cell sarcoma. (23809016)
2013
5
Primary clear cell sarcoma of the tongue. (24168510)
2013
6
Presumed choroidal metastasis secondary to clear cell sarcoma of the right knee. (23053771)
2013
7
Clear cell sarcoma of the kidney misdiagnosed as mesoblastic nephroma: a case report and review of the literature. (23634181)
2013
8
Receptor tyrosine kinase pathway analysis sheds light on similarities between clear-cell sarcoma and metastatic melanoma. (22045652)
2012
9
Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies. (21354804)
2011
10
Clear cell sarcoma of the kidney. (21075398)
2011
11
Tan-pigmented papule in a healthy adolescent male. Clear cell sarcoma of tendons and aponeuroses (CCSTA) (cutaneous clear cell sarcoma). (21576585)
2011
12
Clear cell sarcoma of the mediastinum. (19433300)
2009
13
Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. (19853769)
2009
14
Chopart's amputation for resection of clear cell sarcoma of the foot: a case report and review of the literature. (19857825)
2009
15
Primary gastrointestinal clear cell sarcoma: report of 2 cases, one case associated with IgG4-related sclerosing disease, and review of literature. (19118779)
2009
16
Clear cell sarcoma originating in a paraspinous tendon: case report and literature review. (18607869)
2008
17
Clear cell sarcoma (melanoma of soft parts): The Royal Marsden Hospital experience. (18042498)
2008
18
Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney. (17646270)
2007
19
EWS-CREB1: a recurrent variant fusion in clear cell sarcoma--association with gastrointestinal location and absence of melanocytic differentiation. (17000668)
2006
20
Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues: clinicopathologic and molecular analysis of 44 patients from the French sarcoma group. (16878328)
2006
21
Myxoid clear cell sarcoma. (15677980)
2005
22
Intraoperative massive pulmonary tumor embolism from clear cell sarcoma in the retroperitoneum: successful treatment using cardiopulmonary bypass. (15239230)
2004
23
The management of clear cell sarcoma. (12943620)
2003
24
Classification of clear-cell sarcoma as a subtype of melanoma by genomic profiling. (12721254)
2003
25
Karyotypic divergence and convergence in two synchronous lung metastases of a clear cell sarcoma of tendons and aponeuroses with t(12;22)(q13;q12) and type 1 EWS/ATF1. (12935923)
2003
26
Clear cell sarcoma of the kidney. (11832627)
2001
27
Comparative genomic hybridization analysis of clear cell sarcoma of the kidney. (10657872)
2000
28
Primary clear cell sarcoma of bone: a unique site of origin. (10384998)
1999
29
Clear cell sarcoma of soft parts: report of a case primary in the kidney with cytogenetic confirmation. (10328092)
1999
30
Clear cell sarcoma of the abdominal wall with peritoneal sarcomatosis: CT features. (10525863)
1999
31
Clear cell sarcoma of kidney with tumor extension into the right atrium. (9788798)
1998
32
New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts). (9824209)
1998
33
Long survival with metastatic clear cell sarcoma of the Achilles tendon. (8722877)
1996
34
Clear cell sarcoma of the kidney in an adult. (7972895)
1994
35
An immunohistochemical study comparing clear cell sarcoma of the kidney and Wilms' tumor. (8396229)
1993
36
Congenital sarcoma in the terminal ileum histologically resembling clear cell sarcoma of the kidney: a case report with an immunohistochemical study. (7504650)
1993
37
Reciprocal translocation t(12;22)(q13;q13) in clear-cell sarcoma of tendons and aponeuroses. (1373311)
1992
38
Clear cell sarcoma. An immunohistochemical analysis of six cases and comparison with other epithelioid neoplasms of soft tissue. (2521288)
1989
39
Clear cell sarcoma of tendons and aponeuroses: case presentation with special reference to immunohistochemical findings. (2673981)
1989
40
Clear cell sarcoma of the foot. (3072371)
1988
41
Clear cell sarcoma of the kidney: report of a case with mandibular metastasis simulating a benign myxomatous tumor. (3287257)
1988
42
Unusual renal sarcoma in a young adult: its similarities to clear cell sarcoma of the kidney. (3560336)
1987
43
Clear cell sarcoma of the kidney. An immunohistochemical study. (2426918)
1986
44
Ultrastructural similarities and differences of synovial sarcoma, epithelioid sarcoma, and clear cell sarcoma of the tendons and aponeuroses. (6087526)
1984
45
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
46
Malignant melanoma of soft parts. A reassessment of clear cell sarcoma. (6614306)
1983
47
Clear cell sarcoma of tendons and aponeuroses: electron microscopic findings suggesting Schwann cell differentiation. (6642500)
1983
48
Clear cell sarcoma and selective IgM deficiency: a case report. (7053825)
1982
49
Clear cell sarcoma from tendinous part of quadriceps muscle. (729225)
1978
50
An example of a clear cell sarcoma of tendon. (5363303)
1969

Genetic Variations for Clear Cell Sarcoma

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Expression for genes affiliated with Clear Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Sarcoma

Search GEO for disease gene expression data for Clear Cell Sarcoma.

Pathways for genes affiliated with Clear Cell Sarcoma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ATF1, CREB1
2
Hide members
10.1VIM, DES, ACTC1
310.1ATF1, DDIT3, CREB1
49.9ATF1, DDIT3, TFE3, EWSR1
5
Hide members
9.7ERBB3, DES, ATF1, DDIT3, CREB1, VIM

Compounds for genes affiliated with Clear Cell Sarcoma

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44Novoseek, 24HMDB, 49PharmGKB, 2BitterDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1glycogen44 2411.6ACTC1, CREB1
2creatinine4410.6ACTC1
3askin4410.5EWSR1, ENO2
42-methoxyethanol4410.5ACTC1, S100A1, VIM
5orcein4410.4VIM, ACTC1, DES, S100B
6edss4410.4S100B, ENO2
7reticulin4410.4DES, ACTC1, S100B, VIM
8eosin4410.4VIM, S100B
9actomyosin4410.4ACTC1, VIM, S100A1
10azathioprine44 49 2 1113.3CREB1, H19, VIM, DES
11toluidine4410.3ENO2, DES, S100A1, VIM
12acetylcholine44 49 28 11 2414.3ERBB3, S100A1, ENO2, CREB1
13glucose4410.3ERBB3, ACTC1, DDIT3, TFE3
14mucicarmine4410.3S100B, VIM, ACTC1, DES, S100A1
15dbc-amp4410.3VIM, S100B, ENO2, CREB1
16b 7234410.3VIM, S100B, S100A1, DES, ACTC1
17biotin44 11 2412.3S100A1, DES, ACTC1, VIM
18s 1004410.2VIM, S100B, DES, ACTC1, ENO2
19glutamine4410.2ENO2, DDIT3, CREB1, EWSR1
20agar4410.2CREB1, ERBB3, H19, VIM
21formaldehyde44 2411.2VIM, S100B, DES, ENO2, ACTC1
22acth4410.2ENO2, S100B, CREB1, H19
23ganglioside4410.1ENO2, VIM, DES
24bromodeoxyuridine4410.1S100B, DDIT3, ENO2, VIM, DES
25norepinephrine44 11 2412.1CREB1, S100B, ATF1, ENO2, DES
26gaba4410.1CREB1, S100B, ENO2, VIM
27cyclic amp44 2411.1CREB1, ATF1, EWSR1, S100B, DES, VIM
28etoposide44 49 59 1113.1VIM, ENO2, S100B, DDIT3, CREB1
29forskolin44 49 1112.1ATF1, CREB1, VIM, S100B, ENO2, ERBB3
30adenylate4410.0VIM, DES, CREB1, ENO2, ATF1, S100B
31steroid4410.0ERBB3, DES, ATF1, CREB1, H19, ACTC1
32lactate4410.0ENO2, DES, MLANA, CREB1, S100B, VIM
33zinc44 2411.0S100A1, CREB1, MFI2, EWSR1, H19, S100B
3412-o-tetradecanoylphorbol 13-acetate4410.0VIM, ATF1, DES, CREB1
35heparin44 28 11 2413.0ERBB3, ENO2, DES, S100B, VIM
36hematoxylin449.9MLANA, DES, ACTC1, VIM, S100A1, S100B
37methionine449.9DES, S100B, VIM, DDIT3
38leucine449.9VIM, ENO2, ATF1, DDIT3, CREB1, TFE3
39progesterone44 59 28 11 2413.8VIM, S100A1, S100B, ATF1, DES, ACTC1
40sb 20358044 5910.8ATF1, DDIT3, CREB1, VIM
41testosterone44 59 11 2412.8CREB1, ERBB3, DES, S100B, VIM, ACTC1
42iron44 2410.8DES, ACTC1, DDIT3, S100A1, S100B, VIM
43vegf449.8DDIT3, DES, VIM, ENO2, ERBB3, ACTC1
44atp44 2810.7DDIT3, CREB1, S100B, ENO2, S100A11, VIM
45silver449.7S100A1, ENO2, DES
46oxygen44 2410.7DES, S100B, ENO2, ACTC1, MFI2, DDIT3
47paraffin449.6H19, VIM, S100B, S100A1, EWSR1, MLANA
48retinoic acid44 2410.5CREB1, EWSR1, S100B, S100A1, H19, DDIT3
49tyrosine449.5ENO2, ERBB3, ACTC1, DES, DDIT3, CREB1
50calcium44 49 11 2412.3S100A11, DES, ENO2, ERBB3, ATF1, DDIT3

GO Terms for genes affiliated with Clear Cell Sarcoma

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16Gene Ontology
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Biological processes related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.1ACTC1, DES, VIM

Molecular functions related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.9S100A11, S100A1, S100B
2identical protein bindingGO:0428029.4VIM, S100B, S100A1, EWSR1, DES, ERBB3
3protein bindingGO:0055158.7S100B, S100A1, S100A11, EWSR1, MFI2, CREB1

Products for genes affiliated with Clear Cell Sarcoma

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Sources for Clear Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet