MCID: CLR017
MIFTS: 37

Clear Cell Sarcoma malady

Cancer diseases category

Summaries for Clear Cell Sarcoma

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Disease Ontology:9 A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. it presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

MalaCards based summary: Clear Cell Sarcoma, also known as melanoma, malignant, of soft parts, is related to sarcoma and melanoma. An important gene associated with Clear Cell Sarcoma is ATF1 (activating transcription factor 1), and among its related pathways is Toll Like Receptor 7/8 (TLR7/8) Cascade. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and lymph node.

Wikipedia:63 Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer... more...

Aliases & Classifications for Clear Cell Sarcoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Clear Cell Sarcoma, Aliases & Descriptions:

Name: Clear Cell Sarcoma 9 11
Melanoma, Malignant, of Soft Parts 9
Adult Soft Part Clear Cell Sarcoma 9
Malignant Melanoma of Soft Tissues 9
 
Clear Cell Sarcoma of Soft Parts 9
Sarcoma, Clear Cell 60
Sarcoma Clear Cell 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:4233
MeSH33 D018227
NCIt38 C3745

Related Diseases for Clear Cell Sarcoma

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Diseases in the Clear Cell Sarcoma family:

Small Cell Sarcoma

Diseases related to Clear Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.9DES, ATF1, EWSR1, S100B
2melanoma30.9DES, ATF1, MFI2, EWSR1, S100B
3wilms tumor30.8EWSR1, DES
4myxoid liposarcoma30.6ATF1, EWSR1
5liposarcoma30.5EWSR1, DES
6pleomorphic adenoma30.4S100B, DES
7rhabdomyosarcoma30.2S100B, EWSR1, DES
8melanoma of soft parts10.9
9kidney clear cell sarcoma10.6
10fibrous histiocytoma10.4EWSR1
11ewing's family of tumors10.4EWSR1
12fibrous meningioma10.4S100B
13mesoblastic nephroma10.4
14syringoma10.4S100B
15glomus tumor10.4DES
16tendinitis10.3
17sarcomatosis10.3
18adenoma10.3
19peritonitis10.3
20peripheral primitive neuroectodermal tumor10.3EWSR1, ATF1
21desmoplastic small round cell tumor10.2EWSR1, DES
22myoepithelioma10.2EWSR1, S100B
23spindle cell sarcoma10.2DES, S100B
24cutaneous fibrous histiocytoma10.2S100B, DES
25embryonal rhabdomyosarcoma10.2DES, EWSR1
26granular cell tumor10.2DES, S100B
27neuroblastoma10.1
28adenomatous polyposis coli10.1
29alveolar soft-part sarcoma10.1
30arthritis10.1
31neuroectodermal tumor10.1
32neuronitis10.1
33microphthalmia10.1
34metanephric adenoma10.1
35acral lentiginous melanoma10.1
36gastroduodenitis10.1
37choroiditis10.1
38paraganglioma10.1
39cervicitis10.1
40congenital mesoblastic nephroma10.1
41epithelioid sarcoma10.1
42hepatoblastoma10.1
43malignant pleural mesothelioma10.1
44neuroma10.1
45pericardial effusion10.1
46respiratory failure10.1
47pulmonary vein stenosis10.1
48soft tissue sarcoma10.1
49spitz nevus10.1
50mesothelioma10.1

Graphical network of the top 20 diseases related to Clear Cell Sarcoma:



Diseases related to clear cell sarcoma

Symptoms for Clear Cell Sarcoma

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Drugs & Therapeutics for Clear Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Clear Cell Sarcoma

Search NIH Clinical Center for Clear Cell Sarcoma

Genetic Tests for Clear Cell Sarcoma

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Anatomical Context for Clear Cell Sarcoma

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MalaCards organs/tissues related to Clear Cell Sarcoma:

31
Kidney, Bone, Lymph node, Tongue, Brain, Lung, Small intestine, Colon, Skin, Ovary

Animal Models for Clear Cell Sarcoma or affiliated genes

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Publications for Clear Cell Sarcoma

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Articles related to Clear Cell Sarcoma:

(show top 50)    (show all 395)
idTitleAuthorsYear
1
Diffuse and strong cyclin D1 immunoreactivity in clear cell sarcoma of the kidney. (25556515)
2015
2
Clear cell sarcoma of the kidney distinguished from synovial sarcoma using genetic analysis: a case report. (25888919)
2015
3
Clear cell sarcoma. (25396137)
2014
4
Dual-color, break-apart fluorescence in situ hybridization probe for distinguishing clear cell sarcoma of soft tissue from malignant melanoma. (25312298)
2014
5
Compound clear cell sarcoma misdiagnosed as a Spitz nevus. (23980901)
2013
6
Deep intronic point mutations of the KIT gene in a female patient with cutaneous clear cell sarcoma and her family. (22559980)
2012
7
Cutaneous clear cell sarcoma: a rare aggressive tumor with potential diagnostic challenge. (22923926)
2012
8
Primary clear cell sarcoma of the sacrum: a case report. (21181468)
2011
9
Chemotherapy in clear cell sarcoma. (20390470)
2011
10
Anaplastic variant of clear cell sarcoma of the kidney: a rare case report. (20601342)
2010
11
Clear cell sarcoma of soft tissue metastatic to the ovaries: a heretofore unreported occurrence. (19620941)
2009
12
Clear cell sarcoma of the mediastinum. (19433300)
2009
13
Clear cell sarcoma of the stomach. (19350639)
2009
14
Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. (19853769)
2009
15
Gastrointestinal melanoma or clear cell sarcoma? Molecular evaluation of 7 cases previously diagnosed as malignant melanoma. (18408594)
2008
16
PET monitoring of clear cell sarcoma of tendons and aponeuroses. (17452880)
2007
17
Adult clear cell sarcoma of the kidney: a case report. (16584570)
2006
18
Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue. (16867224)
2006
19
EWS-CREB1: a recurrent variant fusion in clear cell sarcoma--association with gastrointestinal location and absence of melanocytic differentiation. (17000668)
2006
20
Clear cell sarcoma: a dilemma on pathological staging and clinical management. (16020110)
2005
21
Primary clear cell sarcoma of the ileum: an uncommon and misleading site. (16021514)
2005
22
Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. (15474157)
2004
23
Clear cell sarcoma in the era of sentinel lymph node mapping. (15334639)
2004
24
Intraoperative massive pulmonary tumor embolism from clear cell sarcoma in the retroperitoneum: successful treatment using cardiopulmonary bypass. (15239230)
2004
25
Clear cell sarcoma case report: complex karyotype including t(12;22) in primary and metastatic tumor. (15104285)
2004
26
MR findings of clear cell sarcoma: two case reports. (12823916)
2003
27
Gastroduodenal metastases in a clear cell sarcoma patient. (12725335)
2003
28
Establishment and characterisation of a human clear cell sarcoma model in nude mice. (12237889)
2002
29
Clear cell sarcoma (malignant melanoma of soft parts) presenting as cervical myelopathy. (12498499)
2002
30
A clinicopathological study of clear cell sarcoma of the kidney]. (11866983)
2001
31
Comparative genomic hybridization analysis of clear cell sarcoma of the kidney. (10657872)
2000
32
Ovarian sarcoma with pathologic features of clear cell sarcoma of the kidney. (10890934)
2000
33
Primary clear cell sarcoma of bone: a unique site of origin. (10384998)
1999
34
Melanoma of the soft parts (clear cell sarcoma): a case report and review of the literature. (9591793)
1998
35
Insulin-like growth factor 2 gene imprinting in clear cell sarcoma of the kidney. (9385942)
1997
36
Establishment of a new continuous clear cell sarcoma cell line. Morphological and cytogenetic characterization and detection of chimaeric EWS/ATF-1 transcripts. (9247632)
1997
37
Dramatic response to ifosfamide, mesna and doxorubicin chemotherapy regimen in an adult with clear cell sarcoma of the kidney. (8618315)
1996
38
Primary malignant melanoma (clear cell sarcoma) of bone: report of a case arising in the ulna. (8640695)
1996
39
Long survival with metastatic clear cell sarcoma of the Achilles tendon. (8722877)
1996
40
Clear cell sarcoma (malignant melanoma of soft parts). Presentation of two additional cases. (8491327)
1993
41
Clear cell sarcoma of kidney: report of the first Malaysian case. (1374551)
1992
42
Clear cell sarcoma of the tendinous portion of the quadriceps muscle at the knee joint managed by limb-sparing surgery. (3030474)
1986
43
Clear cell sarcoma: report of two cases with ultrastructural observations and review of the literature. (6705328)
1984
44
Clear-cell sarcoma of tendons and aponeuroses: a clinicopathologic study. Presentation of six additional cases with review of the literature. (6467162)
1984
45
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
46
Clear cell sarcoma of tendons and aponeuroses: malignant melanoma of soft tissues? Report of four cases. (556273)
1979
47
Clear-cell sarcoma of tendons and aponeuroses. Report of two cases. (920114)
1977
48
Clear-cell sarcoma of palmar aponeurosis and tendons. (977056)
1976
49
Clear-cell sarcoma of tendons. A study of 4 cases. (4315730)
1969
50
Clear-cell sarcoma of patellar tendon studied by electron microscopy. (4187653)
1969

Variations for Clear Cell Sarcoma

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Expression for genes affiliated with Clear Cell Sarcoma

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Search GEO for disease gene expression data for Clear Cell Sarcoma.

Pathways for genes affiliated with Clear Cell Sarcoma

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Compounds for genes affiliated with Clear Cell Sarcoma

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Compounds related to Clear Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 24)
idCompoundScoreTop Affiliating Genes
1orcein439.8S100B, DES
2s 100439.8S100B, DES
3reticulin439.8DES, S100B
4mucicarmine439.8S100B, DES
5b 723439.8DES, S100B
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.7S100B, DES
7ccl443 2810.7S100B, DES
8hematoxylin439.7S100B, DES
9bromodeoxyuridine439.5S100B, DES
10formaldehyde43 2410.4S100B, DES
11norepinephrine43 24 1211.4S100B, ATF1, DES
12paraffin439.3S100B, EWSR1, DES
13adenylate439.3DES, ATF1, S100B
14progesterone43 28 59 24 1213.2S100B, ATF1, DES
15steroid439.2DES, ATF1, S100B
16arginine439.2S100B, EWSR1, DES
17imatinib43 49 1211.1S100B, DES
18iron43 2410.1DES, MFI2, S100B
19zinc43 2410.0S100B, EWSR1, MFI2
20retinoic acid43 2410.0S100B, EWSR1, DES
21cyclic amp43 249.9S100B, EWSR1, ATF1, DES
22serine438.8S100B, EWSR1, ATF1, DES
23oxygen43 249.7DES, MFI2, S100B
24calcium43 49 24 1211.7DES, ATF1, EWSR1, S100B

GO Terms for genes affiliated with Clear Cell Sarcoma

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Molecular functions related to Clear Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428029.0S100B, EWSR1, DES

Products for genes affiliated with Clear Cell Sarcoma

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Sources for Clear Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet