MCID: CLR017
MIFTS: 45

Clear Cell Sarcoma malady

Cancer diseases category
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Summaries for Clear Cell Sarcoma

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Disease Ontology:8 A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. it presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

MalaCards based summary: Clear Cell Sarcoma, also known as malignant melanoma of soft tissues, is related to sarcoma and melanoma. An important gene associated with Clear Cell Sarcoma is ATF1 (activating transcription factor 1), and among its related pathways is Toll Like Receptor 7/8 (TLR7/8) Cascade. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and lymph node.

Wikipedia:65 Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer... more...

Aliases & Classifications for Clear Cell Sarcoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
See all sources

Clear Cell Sarcoma, Aliases & Descriptions:

Name: Clear Cell Sarcoma 8 10
Malignant Melanoma of Soft Tissues 8 62
Clear Cell Sarcoma of Soft Parts 8 62
Adult Soft Part Clear Cell Sarcoma 8
 
Melanoma, Malignant, of Soft Parts 8
Sarcoma, Clear Cell 62
Sarcoma Clear Cell 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4233
MeSH34 D018227
NCIt39 C3745

Related Diseases for Clear Cell Sarcoma

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Diseases in the Clear Cell Sarcoma family:

Small Cell Sarcoma

Diseases related to Clear Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.9DES, EWSR1, S100B, ATF1
2melanoma30.9ATF1, EWSR1, S100B, DES, MFI2
3wilms tumor30.8DES, EWSR1
4paraganglioma30.8DES
5myxoid liposarcoma30.6EWSR1, ATF1
6liposarcoma30.5EWSR1, DES
7pleomorphic adenoma30.4S100B, DES
8synovial sarcoma30.3DES, S100B
9chondrosarcoma30.2EWSR1, S100B, DES
10rhabdomyosarcoma30.2EWSR1, DES, S100B
11melanoma of soft parts10.9
12kidney clear cell sarcoma10.7
13fibrous histiocytoma10.4EWSR1
14cerebral primitive neuroectodermal tumor10.4EWSR1
15fibrous meningioma10.4S100B
16syringoma10.4S100B
17mesoblastic nephroma10.4
18tendinitis10.3
19sarcomatosis10.3
20adenoma10.3
21peritonitis10.3
22peripheral primitive neuroectodermal tumor10.3EWSR1, ATF1
23desmoplastic small round cell tumor10.2DES, EWSR1
24myoepithelioma10.2S100B, EWSR1
25spindle cell sarcoma10.2S100B, DES
26embryonal rhabdomyosarcoma10.2DES, EWSR1
27cutaneous fibrous histiocytoma10.2DES, S100B
28dermatofibrosarcoma protuberans10.2DES, S100B
29granular cell tumor10.2DES, S100B
30sex cord-gonadal stromal tumor10.1DES, S100B
31arthritis10.1
32neuroectodermal tumor10.1
33metanephric adenoma10.1
34acral lentiginous melanoma10.1
35familial adenomatous polyposis10.1
36microphthalmia10.1
37alveolar soft part sarcoma10.1
38gastroduodenitis10.1
39choroiditis10.1
40cervicitis10.1
41congenital mesoblastic nephroma10.1
42epithelioid sarcoma10.1
43hepatoblastoma10.1
44malignant pleural mesothelioma10.1
45neuroblastoma10.1
46neuroma10.1
47osteosarcoma10.1
48pericardial effusion10.1
49respiratory failure10.1
50pulmonary vein stenosis10.1

Graphical network of the top 20 diseases related to Clear Cell Sarcoma:



Diseases related to clear cell sarcoma

Symptoms for Clear Cell Sarcoma

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Drugs & Therapeutics for Clear Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Clear Cell Sarcoma

Search NIH Clinical Center for Clear Cell Sarcoma

Genetic Tests for Clear Cell Sarcoma

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Anatomical Context for Clear Cell Sarcoma

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MalaCards organs/tissues related to Clear Cell Sarcoma:

32
Kidney, Bone, Lymph node, Tongue, Brain, Lung, Small intestine, Colon, Skin, Ovary

Animal Models for Clear Cell Sarcoma or affiliated genes

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Publications for Clear Cell Sarcoma

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Articles related to Clear Cell Sarcoma:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
Clear cell sarcoma. (25396137)
2014
2
Dual-color, break-apart fluorescence in situ hybridization probe for distinguishing clear cell sarcoma of soft tissue from malignant melanoma. (25312298)
2014
3
Compound clear cell sarcoma misdiagnosed as a Spitz nevus. (23980901)
2013
4
Clinicopathological features, diagnosis and treatment of clear cell sarcoma/melanoma of soft parts. (25031505)
2013
5
Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model. (24389062)
2013
6
Deep intronic point mutations of the KIT gene in a female patient with cutaneous clear cell sarcoma and her family. (22559980)
2012
7
Cutaneous clear cell sarcoma: a rare aggressive tumor with potential diagnostic challenge. (22923926)
2012
8
Primary clear cell sarcoma of the sacrum: a case report. (21181468)
2011
9
Chemotherapy in clear cell sarcoma. (20390470)
2011
10
Anaplastic variant of clear cell sarcoma of the kidney: a rare case report. (20601342)
2010
11
Clear cell sarcoma of soft tissue metastatic to the ovaries: a heretofore unreported occurrence. (19620941)
2009
12
Clear cell sarcoma of the mediastinum. (19433300)
2009
13
Clear cell sarcoma of the stomach. (19350639)
2009
14
Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. (19853769)
2009
15
Gastrointestinal melanoma or clear cell sarcoma? Molecular evaluation of 7 cases previously diagnosed as malignant melanoma. (18408594)
2008
16
PET monitoring of clear cell sarcoma of tendons and aponeuroses. (17452880)
2007
17
Adult clear cell sarcoma of the kidney: a case report. (16584570)
2006
18
Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue. (16867224)
2006
19
EWS-CREB1: a recurrent variant fusion in clear cell sarcoma--association with gastrointestinal location and absence of melanocytic differentiation. (17000668)
2006
20
Clear cell sarcoma: a dilemma on pathological staging and clinical management. (16020110)
2005
21
Primary clear cell sarcoma of the ileum: an uncommon and misleading site. (16021514)
2005
22
Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. (15474157)
2004
23
Clear cell sarcoma in the era of sentinel lymph node mapping. (15334639)
2004
24
Intraoperative massive pulmonary tumor embolism from clear cell sarcoma in the retroperitoneum: successful treatment using cardiopulmonary bypass. (15239230)
2004
25
Clear cell sarcoma case report: complex karyotype including t(12;22) in primary and metastatic tumor. (15104285)
2004
26
MR findings of clear cell sarcoma: two case reports. (12823916)
2003
27
Gastroduodenal metastases in a clear cell sarcoma patient. (12725335)
2003
28
Establishment and characterisation of a human clear cell sarcoma model in nude mice. (12237889)
2002
29
Clear cell sarcoma (malignant melanoma of soft parts) presenting as cervical myelopathy. (12498499)
2002
30
A clinicopathological study of clear cell sarcoma of the kidney]. (11866983)
2001
31
Comparative genomic hybridization analysis of clear cell sarcoma of the kidney. (10657872)
2000
32
Ovarian sarcoma with pathologic features of clear cell sarcoma of the kidney. (10890934)
2000
33
Primary clear cell sarcoma of bone: a unique site of origin. (10384998)
1999
34
Melanoma of the soft parts (clear cell sarcoma): a case report and review of the literature. (9591793)
1998
35
Insulin-like growth factor 2 gene imprinting in clear cell sarcoma of the kidney. (9385942)
1997
36
Establishment of a new continuous clear cell sarcoma cell line. Morphological and cytogenetic characterization and detection of chimaeric EWS/ATF-1 transcripts. (9247632)
1997
37
Dramatic response to ifosfamide, mesna and doxorubicin chemotherapy regimen in an adult with clear cell sarcoma of the kidney. (8618315)
1996
38
Primary malignant melanoma (clear cell sarcoma) of bone: report of a case arising in the ulna. (8640695)
1996
39
Long survival with metastatic clear cell sarcoma of the Achilles tendon. (8722877)
1996
40
Clear cell sarcoma (malignant melanoma of soft parts). Presentation of two additional cases. (8491327)
1993
41
Clear cell sarcoma of kidney: report of the first Malaysian case. (1374551)
1992
42
Clear cell sarcoma of the tendinous portion of the quadriceps muscle at the knee joint managed by limb-sparing surgery. (3030474)
1986
43
Clear cell sarcoma: report of two cases with ultrastructural observations and review of the literature. (6705328)
1984
44
Clear-cell sarcoma of tendons and aponeuroses: a clinicopathologic study. Presentation of six additional cases with review of the literature. (6467162)
1984
45
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
46
Clear cell sarcoma of tendons and aponeuroses: malignant melanoma of soft tissues? Report of four cases. (556273)
1979
47
Clear-cell sarcoma of tendons and aponeuroses. Report of two cases. (920114)
1977
48
Clear-cell sarcoma of palmar aponeurosis and tendons. (977056)
1976
49
Clear-cell sarcoma of tendons. A study of 4 cases. (4315730)
1969
50
Clear-cell sarcoma of patellar tendon studied by electron microscopy. (4187653)
1969

Variations for Clear Cell Sarcoma

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Expression for genes affiliated with Clear Cell Sarcoma

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Expression patterns in normal tissues for genes affiliated with Clear Cell Sarcoma

Search GEO for disease gene expression data for Clear Cell Sarcoma.

Pathways for genes affiliated with Clear Cell Sarcoma

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Compounds for genes affiliated with Clear Cell Sarcoma

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Compounds related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1orcein449.8S100B, DES
2s 100449.8S100B, DES
3reticulin449.8DES, S100B
4mucicarmine449.8S100B, DES
5b 723449.8DES, S100B
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.7S100B, DES
7ccl444 2810.7S100B, DES
8hematoxylin449.7S100B, DES
9bromodeoxyuridine449.5S100B, DES
10formaldehyde44 2410.4S100B, DES
11norepinephrine44 24 1111.4S100B, ATF1, DES
12paraffin449.3S100B, EWSR1, DES
13adenylate449.3DES, ATF1, S100B
14progesterone44 28 61 24 1113.2S100B, ATF1, DES
15steroid449.2DES, ATF1, S100B
16arginine449.2S100B, EWSR1, DES
17imatinib44 50 1111.1S100B, DES
18iron44 2410.1DES, MFI2, S100B
19zinc44 2410.0S100B, EWSR1, MFI2
20retinoic acid44 2410.0S100B, EWSR1, DES
21cyclic amp44 249.9S100B, EWSR1, ATF1, DES
22serine448.8S100B, EWSR1, ATF1, DES
23oxygen44 249.7DES, MFI2, S100B
24calcium44 50 24 1111.7DES, ATF1, EWSR1, S100B

GO Terms for genes affiliated with Clear Cell Sarcoma

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Molecular functions related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.0S100B, EWSR1, DES

Products for genes affiliated with Clear Cell Sarcoma

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Sources for Clear Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet