MCID: CLR017
MIFTS: 44

Clear Cell Sarcoma malady

Cancer diseases category
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Summaries for Clear Cell Sarcoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. it presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

MalaCards: Clear Cell Sarcoma, also known as melanoma, malignant, of soft parts, is related to sarcoma and melanoma. An important gene associated with Clear Cell Sarcoma is ATF1 (activating transcription factor 1), and among its related pathways is Toll Like Receptor 7/8 (TLR7/8) Cascade. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and lymph node.

Wikipedia:65 Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer... more...

Aliases & Classifications for Clear Cell Sarcoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

clear cell sarcoma 8 10
melanoma, malignant, of soft parts 8
adult soft part clear cell sarcoma 8
malignant melanoma of soft tissues 8
clear cell sarcoma of soft parts 8
sarcoma, clear cell 62
sarcoma clear cell 45


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Disease Ontology8 DOID:4233
MeSH35 D018227
NCIt40 C3745

Related Diseases for Clear Cell Sarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Clear Cell Sarcoma family:

Small Cell Sarcoma

Diseases related to Clear Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.1DES, ATF1, EWSR1, S100B
2melanoma31.4DES, ATF1, MFI2, EWSR1, S100B
3wilms tumor30.9EWSR1, DES
4myxoid liposarcoma30.3ATF1, EWSR1
5liposarcoma30.3EWSR1, DES
6pleomorphic adenoma30.2S100B, DES
7synovial sarcoma30.2S100B, DES
8chondrosarcoma30.2DES, EWSR1, S100B
9rhabdomyosarcoma30.2S100B, EWSR1, DES
10melanoma of soft parts10.9
11kidney clear cell sarcoma10.6
12mesoblastic nephroma10.4
13tendinitis10.3
14sarcomatosis10.3
15adenoma10.3
16peritonitis10.3
17microphthalmia10.1
18metanephric adenoma10.1
19alveolar soft part sarcoma10.1
20acral lentiginous melanoma10.1
21gastroduodenitis10.1
22choroiditis10.1
23paraganglioma10.1
24arthritis10.1
25congenital mesoblastic nephroma10.1
26epithelioid sarcoma10.1
27malignant pleural mesothelioma10.1
28neuroblastoma10.1
29neuroma10.1
30osteosarcoma10.1
31pericardial effusion10.1
32respiratory failure10.1
33soft tissue sarcoma10.1
34spitz nevus10.1
35cutaneous malignant melanoma10.1
36fibrous histiocytoma10.1EWSR1
37cerebral primitive neuroectodermal tumor10.1EWSR1
38fibrous meningioma10.1S100B
39syringoma10.1S100B
40glomus tumor10.1DES
41peripheral primitive neuroectodermal tumor10.1EWSR1, ATF1
42desmoplastic small round cell tumor10.0EWSR1, DES
43myoepithelioma10.0EWSR1, S100B
44spindle cell sarcoma10.0DES, S100B
45cutaneous fibrous histiocytoma10.0S100B, DES
46embryonal rhabdomyosarcoma10.0DES, EWSR1
47granular cell tumor10.0DES, S100B
48dermatofibrosarcoma protuberans10.0DES, S100B
49hemangiopericytoma10.0DES, S100B
50sex cord-gonadal stromal tumor10.0DES, S100B

Graphical network of the top 20 diseases related to Clear Cell Sarcoma:



Diseases related to clear cell sarcoma

Symptoms for Clear Cell Sarcoma

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Drugs & Therapeutics for Clear Cell Sarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Clear Cell Sarcoma

Search NIH Clinical Center for Clear Cell Sarcoma

Genetic Tests for Clear Cell Sarcoma

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Anatomical Context for Clear Cell Sarcoma

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33MalaCards
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MalaCards organs/tissues related to Clear Cell Sarcoma:

33
Kidney, Bone, Lymph node, Tongue, Brain, Lung, Colon, Skin, Ovary, Small intestine

Animal Models for Clear Cell Sarcoma or affiliated genes

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Publications for Clear Cell Sarcoma

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52PubMed
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Articles related to Clear Cell Sarcoma:

(show top 50)    (show all 364)
idTitleAuthorsYear
1
Compound clear cell sarcoma misdiagnosed as a Spitz nevus. (23980901)
2013
2
Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model. (24389062)
2013
3
Deep intronic point mutations of the KIT gene in a female patient with cutaneous clear cell sarcoma and her family. (22559980)
2012
4
Cutaneous clear cell sarcoma: a rare aggressive tumor with potential diagnostic challenge. (22923926)
2012
5
Primary clear cell sarcoma of the sacrum: a case report. (21181468)
2011
6
Chemotherapy in clear cell sarcoma. (20390470)
2011
7
Anaplastic variant of clear cell sarcoma of the kidney: a rare case report. (20601342)
2010
8
Clear cell sarcoma of soft tissue metastatic to the ovaries: a heretofore unreported occurrence. (19620941)
2009
9
Clear cell sarcoma of the mediastinum. (19433300)
2009
10
Clear cell sarcoma of the stomach. (19350639)
2009
11
Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. (19853769)
2009
12
Gastrointestinal melanoma or clear cell sarcoma? Molecular evaluation of 7 cases previously diagnosed as malignant melanoma. (18408594)
2008
13
PET monitoring of clear cell sarcoma of tendons and aponeuroses. (17452880)
2007
14
Adult clear cell sarcoma of the kidney: a case report. (16584570)
2006
15
Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue. (16867224)
2006
16
EWS-CREB1: a recurrent variant fusion in clear cell sarcoma--association with gastrointestinal location and absence of melanocytic differentiation. (17000668)
2006
17
Clear cell sarcoma: a dilemma on pathological staging and clinical management. (16020110)
2005
18
Primary clear cell sarcoma of the ileum: an uncommon and misleading site. (16021514)
2005
19
Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. (15474157)
2004
20
Clear cell sarcoma in the era of sentinel lymph node mapping. (15334639)
2004
21
Intraoperative massive pulmonary tumor embolism from clear cell sarcoma in the retroperitoneum: successful treatment using cardiopulmonary bypass. (15239230)
2004
22
Clear cell sarcoma case report: complex karyotype including t(12;22) in primary and metastatic tumor. (15104285)
2004
23
Clear cell sarcoma arising from the chest wall: a case report. (15045547)
2004
24
MR findings of clear cell sarcoma: two case reports. (12823916)
2003
25
Gastroduodenal metastases in a clear cell sarcoma patient. (12725335)
2003
26
Case report: case of clear cell sarcoma surviving with the primary lesion for 20 years after resection of a metastatic lymph node. (14666625)
2003
27
Cytogenetic comparison between clear cell sarcoma and a case of acral clear cell melanoma. (16285301)
2003
28
Establishment and characterisation of a human clear cell sarcoma model in nude mice. (12237889)
2002
29
A clinicopathological study of clear cell sarcoma of the kidney]. (11866983)
2001
30
Comparative genomic hybridization analysis of clear cell sarcoma of the kidney. (10657872)
2000
31
Ovarian sarcoma with pathologic features of clear cell sarcoma of the kidney. (10890934)
2000
32
Primary clear cell sarcoma of bone: a unique site of origin. (10384998)
1999
33
Melanoma of the soft parts (clear cell sarcoma): a case report and review of the literature. (9591793)
1998
34
Insulin-like growth factor 2 gene imprinting in clear cell sarcoma of the kidney. (9385942)
1997
35
Establishment of a new continuous clear cell sarcoma cell line. Morphological and cytogenetic characterization and detection of chimaeric EWS/ATF-1 transcripts. (9247632)
1997
36
Dramatic response to ifosfamide, mesna and doxorubicin chemotherapy regimen in an adult with clear cell sarcoma of the kidney. (8618315)
1996
37
Primary malignant melanoma (clear cell sarcoma) of bone: report of a case arising in the ulna. (8640695)
1996
38
Long survival with metastatic clear cell sarcoma of the Achilles tendon. (8722877)
1996
39
Newly established MST-1 tumour cell line and tumour-infiltrating lymphocyte culture from a patient with soft tissue melanoma (clear cell sarcoma) and their potential applications to patient immunotherapy. (8664053)
1996
40
Clear cell sarcoma (malignant melanoma of soft parts). Presentation of two additional cases. (8491327)
1993
41
Clear cell sarcoma of kidney: report of the first Malaysian case. (1374551)
1992
42
Clear cell sarcoma of the tendinous portion of the quadriceps muscle at the knee joint managed by limb-sparing surgery. (3030474)
1986
43
Clear cell sarcoma: report of two cases with ultrastructural observations and review of the literature. (6705328)
1984
44
Clear-cell sarcoma of tendons and aponeuroses: a clinicopathologic study. Presentation of six additional cases with review of the literature. (6467162)
1984
45
Acral lentiginous melanoma simulating "clear cell sarcoma of tendon and aponeuroses". (6863685)
1983
46
Clear cell sarcoma of tendons and aponeuroses: malignant melanoma of soft tissues? Report of four cases. (556273)
1979
47
Clear-cell sarcoma of tendons and aponeuroses. Report of two cases. (920114)
1977
48
Clear-cell sarcoma of palmar aponeurosis and tendons. (977056)
1976
49
Clear-cell sarcoma of tendons. A study of 4 cases. (4315730)
1969
50
Clear-cell sarcoma of patellar tendon studied by electron microscopy. (4187653)
1969

Variations for Clear Cell Sarcoma

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Expression for genes affiliated with Clear Cell Sarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clear Cell Sarcoma

Search GEO for disease gene expression data for Clear Cell Sarcoma.

Pathways for genes affiliated with Clear Cell Sarcoma

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50PathCards, 55Reactome
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Compounds for genes affiliated with Clear Cell Sarcoma

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1orcein459.8S100B, DES
2s 100459.8S100B, DES
3reticulin459.8DES, S100B
4mucicarmine459.8S100B, DES
5b 723459.8DES, S100B
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.7S100B, DES
7ccl445 2910.7S100B, DES
8hematoxylin459.7S100B, DES
9bromodeoxyuridine459.5S100B, DES
10formaldehyde45 2410.4S100B, DES
11norepinephrine45 24 1111.4S100B, ATF1, DES
12paraffin459.3S100B, EWSR1, DES
13adenylate459.3DES, ATF1, S100B
14progesterone45 29 61 24 1113.2S100B, ATF1, DES
15steroid459.2DES, ATF1, S100B
16arginine459.2S100B, EWSR1, DES
17imatinib45 51 1111.1S100B, DES
18iron45 2410.1DES, MFI2, S100B
19zinc45 2410.0S100B, EWSR1, MFI2
20retinoic acid45 2410.0S100B, EWSR1, DES
21cyclic amp45 249.9S100B, EWSR1, ATF1, DES
22serine458.8S100B, EWSR1, ATF1, DES
23oxygen45 249.7DES, MFI2, S100B
24calcium45 51 24 1111.7DES, ATF1, EWSR1, S100B

GO Terms for genes affiliated with Clear Cell Sarcoma

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16Gene Ontology
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Molecular functions related to Clear Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.0S100B, EWSR1, DES

Products for genes affiliated with Clear Cell Sarcoma

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Sources for Clear Cell Sarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet