Cleft Lip malady

Wikipedia: Cleft lip (cheiloschisis) and cleft palate (palatoschisis), which can also occur together as cleft lip...⁴⁴ more...

MalaCards: Cleft Lip, also known as cleft lip, unilateral, complete, is related to stickler syndrome and cleft palate. An important gene associated with Cleft Lip is TP63 (tumor protein p63), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Basal cell carcinoma. The compounds heparan sulfate and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and skin, and related mouse phenotypes are growth/size and limbs/digits/tail.

Aliases & Descriptions:

cleft lip 6 8 32 cleft lip, unilateral, complete 6 complete unilateral cleft lip 6

labium leporinum 6 cheiloschisis 6 hare lip 6

Diseases related to cleft lip by text searches and GeneDecks gene sharing:

(show top 50)    (show all 481)

id	Related Disease	Score	Top Affiliating Genes
1	stickler syndrome	38.9	ZNF618, ZNF462, SH2D3C, RFC1, SERINC1, BSPRY
2	cleft palate	33.8	RFC1, KIAA1598, VAX1, BMP4, BMPR1A, RARA
3	amelia cleft lip palate hydrocephalus iris coloboma	33.6	BHMT, BAG4, MTHFR, LARGE, IRF6, FKRP
4	ectodermal dysplasia	32.3	MSX1, IRF6, FGF10, FGFR2, TP63, DLX3
5	orofacial cleft	32.1	BMP4, RARA, BHMT, BHMT2, BCL3, MTRR
6	birth defects	31.1	BMP4, MTRR, MTHFR, MTR, MTHFD1, MSX1
7	ectrodactyly	30.8	FGF8, GLI2, TP63, SNX3, TGIF1, DHCR7
8	amelogenesis imperfecta	30.8	MSX1, MSX2, MMP25, ENAM, TP63, DLX3
9	kallmann syndrome	30.5	CHD7, KAL1, FGF8, FGFR1, AKAP2, PROK2
10	walker-warburg syndrome	30.3	LARGE, FKRP, FKTN, POMT2, POMT1
11	cleft palate, isolated	30.2	SATB2, FOXE1, C9orf156, HEMGN
12	crouzon syndrome	30.2	MSX2, FGFR1, FGFR2, TWIST1
13	basal cell carcinoma	29.8	RARA, MMP1, MMP3, FOXE1, GSTM1, GSTT1
14	hypodontia	29.6	PAX9, MSX1, MMP9, IRF6, FGF10, FGF3
15	diffuse gastric cancer	29.4	MTR, CDH1, GSTM1, GSTP1, GSTT1, ERBB2
16	congenital heart defect	27.9	MTHFR, CD79A, MMP1, MMP3, MMP9, FGF1
17	polycystic kidney disease	27.8	RARA, MSX2, CD79A, MMP9, FGF7, FGFR2
18	carcinoma	24.1	RFC1, BMP4, BMP7, BMPR1A, RARA, LIPC
19	gastric cancer	23.3	RFC1, BMP4, BMP7, BMPR1A, RARA, MTHFR
20	tooth agenesis	14.5	BMP4, PAX9, CHD7, MSX1, MSX2, KAL1
21	placental abruption	14.3	RFC1, BHMT, PAPPA, MTRR, MTHFR, MTHFD1
22	dentin dysplasia	14.3	PAX9, MSX1, MSX2, MMP25, ENAM, DSPP
23	homocysteinemia	14.3	MTRR, MTHFR, MTR, CBS, SLC19A1
24	achondroplasia	14.3	PAPPA, MSX2, FGF18, FGF3, FGF9, FGFR1
25	syndactyly	14.3	MSX2, FGF10, FGF8, FGFR1, FGFR2, TP63
26	craniosynostosis, syndromic	14.2	MSX2, FGF10, FGF7, FGF9, FGFR1, FGFR2
27	pediatric osteosarcoma	14.2	RFC1, MTHFR, MTR, PDGFRA, TWIST1, SLC19A1
28	myelomeningocele	14.2	MTRR, MTHFR, MTR, MTHFD1, CBS
29	anosmia	14.2	CHD7, KAL1, FGF8, FGFR1, PROK2, PROKR2
30	renal agenesis	14.2	CHD7, KAL1, FMN1, FGF10, FGF8, FGFR1
31	polydactyly	14.2	BMP4, MSX1, MSX2, FGF8, FGFR2, GLI2
32	klinefelter's syndrome	14.2	CHD7, MTHFR, KAL1, FGF8, FGFR1, PROK2
33	dentinogenesis imperfecta	14.2	MSX1, MMP25, ENAM, TNC, DLX3, DSPP
34	holoprosencephaly	14.1	BMP4, FGF8, GLI2, PTCH1, TGIF1, DHCR7
35	muscular dystrophy-dystroglycanopathy	14.1	LARGE, FKRP, FKTN, POMT2, POMT1
36	folic acid deficiency anemia	14.1	MTHFR, MTR, FPGS, CBS, SLC19A1
37	homocysteine plasma level	14.1	RFC1, MTRR, MTHFR, MTR, EDN1, TCN2
38	neural tube defect	14.1	MTRR, MTHFR, MTR, MTHFD1, FOLR2, CBS
39	acrocephalosyndactylia	14.1	FGF10, FGF7, FGFR1, FGFR2
40	ladd syndrome	14.1	FGF10, FGF3, FGF9, FGFR2
41	muscle-eye-brain disease	14.0	LARGE, FKRP, FKTN, POMT2, POMT1
42	tricho-dento-osseous syndrome	14.0	TP63, DLX3, DSPP
43	teratocarcinoma	14.0	RARA, FGF18, FGF3, FGF7, FGF8, FGF9
44	hypogonadotropism	14.0	CHD7, KAL1, FGF8, FGFR1, NOG, PROK2
45	homocystinuria	14.0	BHMT, MTRR, MTHFR, MTR, CBS, TCN2
46	hyperhomocysteinemia	14.0	BHMT, MTRR, MTHFR, MTR, MTHFD1, ITGB3
47	papillary thyroid carcinoma	14.0	RARA, CDH1, FOXE1, FGFR1, TP63, PTCH1
48	thiamine-responsive megaloblastic anemia syndrome	14.0	MTRR, MTHFR, MTR, TCN2
49	dental enamel hypoplasia	14.0	MSX2, DLX3, DLX4, DSPP
50	infectious mononucleosis	13.9	FGF10, FGF7, FGF8, FGFR1, FGFR2, TWIST1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cleft lip:

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MGI Mouse Phenotypes related to cleft lip:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	BMP4, BMP7, BMPR1A, RARA, PBX3, BHMT
2	limbs/digits/tail phenotype	MP:0005371	INF	LMX1B, BMP4, BMP7, BMPR1A, RARA, PAX9
3	mortality/aging	MP:0010768	INF	SH2D3C, LMX1B, VAX1, BMP4, BMP7, BMPR1A
4	embryogenesis phenotype	MP:0005380	INF	PAX9, CHD7, SATB2, MSX1, MSX2, JAG2
5	cellular phenotype	MP:0005384	INF	SH2D3C, LMX1B, VAX1, BMP4, BMPR1A, RARA
6	behavior/neurological phenotype	MP:0005386	INF	SH2D3C, LMX1B, BMP4, BMPR1A, PBX3, PAX9
7	skeleton phenotype	MP:0005390	INF	LMX1B, VAX1, BMP4, BMP7, BMPR1A, RARA
8	digestive/alimentary phenotype	MP:0005381	INF	VAX1, BMP4, BMP7, RARA, PBX3, PAX9
9	craniofacial phenotype	MP:0005382	INF	LMX1B, VAX1, BMP4, BMPR1A, PBX3, PAX9
10	renal/urinary system phenotype	MP:0005367	INF	LMX1B, BMP4, BMP7, RARA, BHMT, FYN
11	other phenotype	MP:0005395	9.8	RARA, LAMA4, ITGB3, FKTN, HSF2, TP73
12	pigmentation phenotype	MP:0001186	9.1	BMP7, BMPR1A, MSX2, FMN1, FGFR2, CCL2
13	tumorigenesis	MP:0002006	8.4	BMPR1A, RARA, BHMT, CDH1, ITGB3, MMP9
14	no phenotypic analysis	MP:0003012	8.2	SH2D3C, LMX1B, BMP4, MTHFR, FZD7, FYN
15	normal phenotype	MP:0002873	INF	LMX1B, BMP4, BMP7, BMPR1A, RARA, PAX9
16	immune system phenotype	MP:0005387	INF	SH2D3C, BMPR1A, RARA, PAX9, BCL3, CHD7
17	respiratory system phenotype	MP:0005388	INF	BMPR1A, PBX3, PAX9, CHD7, MSX1, JAG2
18	nervous system phenotype	MP:0003631	INF	SH2D3C, LMX1B, VAX1, BMP4, BMP7, BMPR1A
19	hearing/vestibular/ear phenotype	MP:0005377	INF	BMP4, BMP7, BMPR1A, RARA, PAX9, CHD7
20	vision/eye phenotype	MP:0005391	INF	LMX1B, VAX1, BMP4, BMP7, BMPR1A, RARA
21	reproductive system phenotype	MP:0005389	INF	SH2D3C, BMP7, BMPR1A, RARA, LIPC, PAX9
22	muscle phenotype	MP:0005369	INF	LMX1B, BMP4, BMPR1A, RARA, PAX9, LAMA4
23	hematopoietic system phenotype	MP:0005397	INF	SH2D3C, BMP4, BMPR1A, PAX9, BCL3, CHD7
24	integument phenotype	MP:0010771	INF	LMX1B, PBX3, MSX1, MSX2, FYN, JAG2
25	cardiovascular system phenotype	MP:0005385	INF	LMX1B, BMP4, BMP7, BMPR1A, RARA, CHD7
26	homeostasis/metabolism phenotype	MP:0005376	INF	LMX1B, BMP4, BMPR1A, LIPC, PBX3, BHMT
27	endocrine/exocrine gland phenotype	MP:0005379	INF	BMPR1A, PAX9, CHD7, SATB2, MSX1, MSX2

Articles related to cleft lip:

(show top 50)    (show all 205)

id	Title	Authors	Year	Affiliating Genes
1	Allelic polymorphism of MTHFR, MTR and MTRR genes in patients with cleft lip and/or palate and their mothers]. (21774403)	Chorna L.B.... Fedoryk I.M.	2011	MTR, MTHFR, MTRR
2	Variation in FGF1, FOXE1, and TIMP2 genes is associat ed with nonsyndromic cleft lip with or without cleft palate. (21462296)	Nikopensius T.... Metspalu A.	2011	FGF1, TIMP2, FOXE1
3	Cleft lip with cleft palate, ankyloglossia, and hypod ontia are associated with TBX22 mutations. (21248356)	Kantaputra P.N.... Stanier P.	2011	TBX22
4	Association of Wnt3A gene variants with non-syndromic cleft lip with or without cleft palate in Chinese population. (20932509)	Yao T.... Xie X.D.	2011	WNT3A
5	Transforming growth factor beta-3 and environmental f actors and cleft lip with/without cleft palate. (20408761)	Guo Z.... Gong B.	2010	TGFB3
6	Lack of association between IRF6 polymorphisms (rs223 5371 and rs642961) and non-syndromic cleft lip and/or palate in a Brazilian pop ulation. (19780991)	ParanaA-ba L.M.... Coletta R.D.	2010	IRF6
7	MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (20572854)	JagomAogi T.... Metspalu A.	2010	RARA, JAG2, TGFB3
8	Dermatologic findings of ankyloblepharon-ectodermal d efects-cleft lip/palate (AEC) syndrome. (19681128)	Julapalli M.R.... Bree A.F.	2009	TP63
9	Association analysis between the IRF6 G820A polymorphism and nonsyndromic cleft lip and/or cleft palate in a Chinese population. (19115793)	Tang W.... Tian W.	2009	IRF6
10	Non-syndromic cleft lip/cleft palate and C677T methy lene-tetrahydrofolate reductase variant in Mexican children]. (20550866)	DA!valos-RodrA-guez I.P.... Ledezma-GA^mez V.	2009	MTHFR
11	MICA gene polymorphism not associated with nonsyndrom ic cleft lip with or without cleft palate in the Japanese population? (19594363)	Tamaki S.... Kirita T.	2009	MICA
12	Maternal medication use, carriership of the ABCB1 343 5C > T polymorphism and the risk of a child with cleft lip with or without c left palate. (19760622)	Bliek B.J.... Steegers-Theunissen R.P.	2009	ABCB1
13	Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. (19114084)	Marinucci L.... Lumare E.	2009	FMOD
14	Holoprosencephaly, ectrodactyly, and bilateral cleft of lip and palate: exclusion of SHH, TGIF, SIX3, GLI2, TP73L, and DHCR7 as cand idate genes. (19449411)	Zechi-Ceide R.M.... Richieri-Costa A.	2009	DHCR7, TGIF1, SIX3
15	The common MTHFR C677T and A1298C variants are not as sociated with the risk of non-syndromic cleft lip/palate in northern Venezuela. (19447376)	SAPzen M.A.... Spritz R.A.	2009	MTHFR
16	Searching for genes for cleft lip and/or palate based on breakpoint analysis of a balanced translocation t(9;17)(q32;q12). (19929093)	Machida J.... Ono T.	2009	CCL2, SLC31A1, BSPRY
17	MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population. (19419265)	Ali A.... Raman R.	2009	MTHFR, IRF6
18	Evidence that TGFA influences risk to cleft lip with/ without cleft palate through unconventional genetic mechanisms. (19444471)	Sull J.W.... Beaty T.H.	2009	TGFA
19	Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. (19270707)	Birnbaum S.... Mangold E.	2009	IRF6, GSDMC, PVT1
20	Family-based association study of the MTHFR polymorphism C677T in patients with nonsyndromic cleft lip and palate from central Europe. (18452350)	Reutter H.... Mangold E.	2008	MTHFR
21	Investigation of MYH14 as a candidate gene in cleft lip with or without cleft palate. (18471249)	Martinelli M.... Carinci F.	2008	MYH14
22	Study of the poliovirus receptor related-1 gene in Thai patients with non-syndromic cleft lip with or without cleft palate. (18356023)	Tongkobpetch S.... Shotelersuk V.	2008	PVRL1
23	Identification of novel candidate genes associated with cleft lip and palate using array comparative genomic hybridisation. (17873121)	Osoegawa K.... de Jong P.J.	2008	FGFR2, IRF6
24	Association of MSX1 with nonsyndromic cleft lip and palate in a Colombian population. (18177186)	Otero L.... Bermudez L.	2007	MSX1
25	Sequence evaluation of FGF and FGFR gene conserved non-coding elements in non-syndromic cleft lip and palate cases. (17963255)	Riley B.M.... Murray J.C.	2007	FGFR1, FGF1
26	A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23. (17366557)	Riley B.M.... Murray J.C.	2007	FGFR1, BAG4
27	Human genetic factors in nonsyndromic cleft lip and palate: an update. (17606301)	Carinci F.... Pezzetti F.	2007	MSX1, IRF6
28	Association of transforming growth factor-alpha gene polymorphism and environment factors with nonsyndromic cleft lip with or without cleft palate in Han nationality (17629209)	Yuan K.F.... Qin Y.F.	2007	TGFA
29	Transmission disequilibrium test for nonsyndromic cleft lip and palate and segment homeobox gene-1 gene (18070437)	Wu P.A.... Fan G.Z.	2007	MSX1
30	Genetic origin of non-syndromic cleft lip and palate. TWIST, a candidate gene? Research protocol (18082115)	Bacon W.... Perrin-Schmitt F.	2007	TWIST1
31	Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China. (16470725)	Zhu J.... Li Z.	2006	MTHFR
32	Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer. (15831593)	Frebourg T.... Seruca R.	2006	CDH1
33	PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses. (16247549)	Ichikawa E.... Yoshiura K.	2006	TGFB3, PVRL1, PAX9
34	A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. (16681403)	Watanabe A.... Yoshiura K.	2006	EPHB2, EPHB3, RYK
35	Relationship between transforming growth factor-alpha gene polymorphism and non-syndromic cleft lip with cleft palate (17334078)	Yuan K.F.... Zhou X.H.	2006	TGFA
36	Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population. (16132054)	Ghassibe M.... Vikkula M.	2005	IRF6
37	Mutational analysis of the muscle segment homeobox gene 1 (MSX1) in Chilean patients with cleft lip/palate (15379328)	Vieira A.R.... Murray J.C.	2004	MSX1
38	Transforming growth factor-beta3 gene SfaN1 polymorphism in Korean nonsyndromic cleft lip and palate patients. (14659070)	Kim M.H.... Nahm D.S.	2003	TGFB3
39	Genome scan for loci involved in cleft lip with or without cleft palate, in Chinese multiplex families. (12087515)	Marazita M.L.... Liu Y.E.	2002	OFC4
40	Unravelling the complex genetics of cleft lip in the mouse model. (11353389)	Juriloff D.M.... Brown C.J.	2001	WNT3, DLX3, WNT9B
41	X-linked mental retardation associated with cleft lip/palate maps to Xp11.3-q21.3. (10398231)	Siderius L.E.... Mariman E.C.	1999	PHF8
42	Increased occurrence of cleft lip in glycogen storage disease type II (GSDII): exclusion of a contiguous gene syndrome in two patients by presence of intragenic mutations including a novel nonsense mutation Gln58Stop. (10377006)	Huie M.L.... Hirschhorn R.	1999	GAA
43	Natal teeth in cleft lip and palate patients: a scann ing electron microscopy study. (9206364)	Motoyama L.C.... Watanabe I.S.	1996	DSPP
44	Nonsyndromic cleft lip with or without cleft palate: evidence of linkage to BCL3 in 17 multigenerational families. (7668251)	Stein J.... Hecht J.T.	1995	OFC3
45	Possible localization of a major gene for cleft lip and palate to 4q. (7820940)	Beiraghi S.... Hodes M.E.	1994	OFC4
46	Transforming growth factor alpha: a modifying locus for nonsyndromic cleft lip with or without cleft palate? (7834275)	Field L.L.... Marazita M.L.	1994	TGFA
47	Cleft lip and palate in the Chilean population: association with BamH1 polymorphism of the transforming growth factor alpha (TGFA) gene (8272608)	Jara L.... Curtis D.	1993	TGFA
48	Ankyloblepharon-Ectodermal Defects -Cleft Lip/Palate Syndrome (20556892)	Sutton V.R.... van Bokhoven H.	1993	TP63
49	Genetic variation in transforming growth factor alpha : possible association of BamHI polymorphism with bilateral sporadic cleft lip and palate. (1347971)	Stoll C.... May E.	1992	TGFA
50	Further evidence for an association between genetic v ariation in transforming growth factor alpha and cleft lip and palate. (1673285)	Chenevix-Trench G.... Martin N.	1991	TGFA

Genes related to cleft lip according to GeneCards:

(show top 50)    (show all 226)

id	Symbol	Description	Score	GeneCards Section Context
1	TP63	tumor protein p63	11.1	Summaries, Publications
2	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	11.1	Summaries, Publications
3	TGFA	transforming growth factor, alpha	11.1	Publications, Functions, Summaries
4	MSX1	msh homeobox 1	11.1	Functions, Summaries, Publications
5	TBX10	T-box 10	11.1	Publications, Summaries
6	MID1	midline 1 (Opitz/BBB syndrome)	11.1	Summaries, Publications
7	EEC2	ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome 2	11.1	Aliases & Descriptions
8	EEC1	ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome 1	11.1	Aliases & Descriptions, Publications
9	CLPTM1	cleft lip and palate associated transmembrane protein 1	11.1	Databases, Aliases & Descriptions, Functions, Proteins (show all 8 sections) UniProt Related, Orthologs, Publications, Transcripts
10	CLPTM1L	CLPTM1-like	11.1	Orthologs, Proteins, Aliases & Descriptions
11	OGS2	Opitz G syndrome, type II	11.0	Summaries
12	IRF6	interferon regulatory factor 6	11.0	Publications
13	TGFB3	transforming growth factor, beta 3	11.0	Publications, Functions
14	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
15	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
16	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
17	TBX22	T-box 22	11.0	Publications
18	PHF8	PHD finger protein 8	11.0	Publications, Orthologs
19	PAX9	paired box 9	11.0	Publications
20	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	11.0	Publications
21	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Publications
22	FGF10	fibroblast growth factor 10	11.0	Publications
23	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	11.0	Publications
24	RARA	retinoic acid receptor, alpha	11.0	Publications
25	GSTM1	glutathione S-transferase mu 1	11.0	Publications
26	OFC4	Orofacial cleft 4	11.0	Publications
27	OFC3	orofacial cleft 3	11.0	Publications
28	TMEFF1	transmembrane protein with EGF-like and two follistatin-like domains 1	11.0	Publications
29	WNT8A	wingless-type MMTV integration site family, member 8A	11.0	Publications
30	BARX1	BARX homeobox 1	11.0	Publications
31	C9orf174	chromosome 9 open reading frame 174	11.0	Publications
32	HS3ST5	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	11.0	Publications
33	FOXE1	forkhead box E1 (thyroid transcription factor 2)	11.0	Publications
34	DLX3	distal-less homeobox 3	11.0	Publications
35	LHX8	LIM homeobox 8	11.0	Publications
36	C9orf156	chromosome 9 open reading frame 156	11.0	Publications
37	WNT9B	wingless-type MMTV integration site family, member 9B	11.0	Publications
38	MTRF1L	mitochondrial translational release factor 1-like	11.0	Publications
39	RWDD1	RWD domain containing 1	11.0	Publications
40	FZD7	frizzled family receptor 7	11.0	Publications
41	C9orf43	chromosome 9 open reading frame 43	11.0	Publications
42	TAAR6	trace amine associated receptor 6	11.0	Publications
43	AKAP2	A kinase (PRKA) anchor protein 2	11.0	Publications
44	LINC00474	long intergenic non-protein coding RNA 474	11.0	Publications
45	C6orf211	chromosome 6 open reading frame 211	11.0	Publications
46	BSPRY	B-box and SPRY domain containing	11.0	Publications
47	OSR1	odd-skipped related 1 (Drosophila)	11.0	Publications
48	WSB1	WD repeat and SOCS box containing 1	11.0	Publications
49	OR1K1	olfactory receptor, family 1, subfamily K, member 1	11.0	Publications
50	TRIM14	tripartite motif containing 14	11.0	Publications

Pathways related to cleft lip according to GeneDecks:

(show top 50)    (show all 105)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	11.0	BMP4, BMP7, FGF10, FGF18, TGFB3, TGFBR1
2	Basal cell carcinoma20	10.6	WNT11, PTCH1, GLI2, FZD7, BMP4, WNT3
3	Hedgehog signaling pathway20	10.5	WNT5A, WNT7A, WNT8A, WNT9B, BMP4, WNT3A
4	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	10.2	MTR, GART, MTRR, MTHFR, MTHFD1, FPGS
5	JNK Pathway36	10.2	FGF1, BMP7, BMP4, EPHB3, FGF7, FGFR1
6	Human Embryonic Stem Cell Pluripotency36	9.8	WNT8A, WNT7A, WNT5A, WNT3A, WNT3, PDGFRA
7	Angiogenesis3	9.7	TGFA, ITGB3, TGFB3, TGFB1, TGFB2, TGFBR1
8	Colorectal Cancer Metastasis36	9.4	TGFB1, TGFB2, TGFBR1, STAT3, TGFB3, WNT11
9	Molecular Mechanisms of Cancer36	9.4	FYN, TGFB2, TGFB1, FGF10, TIMP2, EGFR
10	Transcription_Androgen Receptor nuclear signaling41	9.4	EGFR, WNT9B, WNT8A, WNT7A, TGFB1, TGFBR1
11	Transcription Androgen Receptor nuclear signaling10	9.3	WNT5A, WNT8A, WNT9B, WNT7A, WNT3A, WNT3
12	Renin-Angiotensin Pathway36	INF	TGFBR1, TGFB2, TGFB3, TGFA, TIMP2, EGFR
13	Paxillin Interactions36	INF	EGFR, TGFA, TGFB2, BMP4, ITGB3, FGF1
14	Cellular Apoptosis Pathway36	INF	FGFR2, FGFR1, , FGF7, FGF18, FGF10
15	Telomerase Components in Cell Signaling36	INF	BMP4, BMP7, TGFA, FGF1, TGFB3, TIMP2
16	NF-KappaB Family Pathway36	INF	TLR4, BMP4, FYN, TGFB3, TGFB2, TGFB1
17	14-3-3 Induced Intracellular Signaling36	INF	BMP4, FGF18, BMP7, FGF1, FGF10, FGF7
18	p53 Mediated Apoptosis36	INF	BMP4, FGF7, , FGFR1, FGFR2, PDGFRA
19	NFAT in Immune Response36	INF	BMP4, TIMP2, TGFA, TGFB1, ERBB2, TGFB2
20	Nanog in Mammalian ESC Pluripotency36	INF	PDGFRA, ERBB2, FGFR2, FGFR1, BMP4, BMP7
21	ERK5 Signaling36	INF	FGFR1, , FGF18, FGF10, FGF1, FOXO3
22	Pathways in cancer20	INF	WNT8A, WNT7A, WNT5A, WNT3A, WNT3, WNT11
23	Ras Pathway36	INF	RYK, ITGB3, BMP4, BMP7, FGF1, FGFR2
24	eNOS Signaling36	INF	EPHB3, EGFR, TGFB2, TGFB3, TGFA, RYK
25	PPAR Pathway36	INF	, FGF7, FGF18, FGF10, FGF1, ITGB3
26	GPCR Pathway36	INF	FGF1, TGFB3, STAT3, STAT5B, RYK, EPHB2
27	ILK Signaling36	INF	CDH1, CDH2, LAMA4, BMP7, BMP4, TGFB1
28	Rac1 Pathway36	INF	TGFBR3, , FGF7, FGF18, FGF10, FGF1
29	MAPK Signaling36	INF	TGFBR1, PDGFRA, COL27A1, TNC, ERBB2, FGFR2
30	JAK-STAT Pathway36	INF	EPHB3, EGFR, FGF7, TGFA, TGFB1, TGFB2
31	Epithelial Adherens Junctions36	INF	FGF18, EGFR, PTPN3, ERBB2, FGFR1,
32	Tec Kinases Signaling36	INF	PDGFRA, TLR4, TIMP2, TGFA, EGFR, TGFB2
33	TGF-Beta Pathway36	INF	BMP7, CDH1, FGF1, BMP4, FGF10, FGF18
34	Phospholipase-C Pathway36	INF	BMP7, LAMA4, FYN, CD79A, BMP4,
35	Apoptotic Pathways in Synovial Fibroblasts36	INF	TGFB1, TIMP2, FGFR2, FGFR1, , FGF7
36	eIF2 Pathway36	INF	EGFR, TIMP2, TGFA, TGFB2, TGFB3, TGFBR3
37	Pancreatic Adenocarcinoma36	INF	EPHB2, EPHB3, RYK, MMP1, FGF10, BMP4
38	Rap1 Pathway36	INF	FGF1, ITGB3, FYN, BMP7, FGF10, FGF18
39	Activation of PKC through GPCR36	INF	TGFA, TGFB1, PDGFRA, TGFB3, TGFBR1, TGFBR3
40	GSK3 Signaling36	INF	TGFA, TIMP2, EGFR, PDGFRA, ERBB2, FGFR1
41	Mitochondrial Apoptosis36	INF	EGFR, TIMP2, FGFR1, TGFB2, TGFB3, TGFBR3
42	Breast Cancer Regulation by Stathmin136	INF	EPHB3, RYK, TGFBR3, TGFBR1, BMP4, BMP7
43	PTEN Pathway36	INF	FGFR2, PDGFRA, FGFR1, , FGF7, FGF18
44	P2Y Receptor Signaling36	INF	FGF10, FGF18, FGF3, EPHB2, , FGF9
45	p70S6K Signaling36	INF	FGFR1, , FGF7, FGF18, FGF10, FGF1
46	Rho Family GTPases36	INF	EPHB3, ERBB2, EPHB2, RYK, TGFB3, TGFB2
47	Nuclear Receptor Activation by Vitamin-A36	INF	FGFR1, , FGF7, FGF18, FGF10, FGF1
48	Estrogen Pathway36	INF	, FGF7, FGF18, FGF10, BMP7, BMP4
49	DHA Signaling36	INF	PDGFRA, BMP7, FGF1, FGF10, FGF18, FGF7
50	PAK Pathway36	INF	FGF18, FGF10, TGFA, FGF1, TGFBR3, TGFBR1

Compounds related to cleft lip according to GeneDecks:

(show top 50)    (show all 142)

id	Compound	Score	Top Affiliating Genes
1	heparan sulfate32 18	INF	BMP4, LIPC, PAPPA, , FGF1, FGF10
2	tyrosine32	INF	LMX1B, BMP4, BMP7, RARA, LIPC, PAPPA
3	serine32	INF	BMP4, BMP7, BMPR1A, RARA, LIPC, BHMT
4	agar32	10.9	RARA, CDH1, FGF1, FGF3, FGF7, FGFR1
5	cystathionine32	10.8	BHMT, MTRR, MTHFR, MTR, MTHFD1, CBS
6	glycosaminoglycan32	10.7	PAPPA, FMOD, FGF1, FGF7, FGFR2, TNC
7	methylcobalamin32 18	11.7	MTRR, MTHFR, MTR, CBS, TCN1, TCN2
8	p00332	10.5	LIPC, UCP1, MTRR, CDH1, TP63, TNC
9	5-methyltetrahydrofolate32 9 9	12.5	MTRR, MTHFR, MTR, FOLR2, CBS, SLC19A1
10	cobalamin32 18	11.4	MTRR, MTHFR, MTR, MTHFD1, CBS, TCN1
11	homocysteine32 18	11.3	BHMT, BHMT2, MTRR, MTR, MTHFD1, CCL2
12	rapamycin32 42	11.1	BMP4, BCL3, FOXO3, FGF7, PDGFRA, EGFR
13	chi 232	10.1	PAPPA, MTHFR, CDH1, GSTM1, GSTT1, TIMP2
14	methionine32	10.0	LIPC, MTHFD1, MMP3, FOLR2, GSTT1, FGF9
15	p00232	10.0	LIPC, PAPPA, UCP1, MTHFR, CDH1, MMP3
16	progesterone32 42 9 18 9	13.8	BMP4, BMP7, RARA, PAPPA, UCP1, CDH2
17	batimastat32 42 9 9	12.8	MMP1, MMP25, MMP3, MMP9, ERBB2, EGFR
18	tgf beta132	9.8	BMP4, BMP7, RARA, CDH1, MMP1, MMP3
19	pge232	9.8	BMP4, BMP7, CDH1, MMP1, MMP3, FGF1
20	matrigel32	9.7	BMP4, CDH2, CDH1, MMP1, MMP3, MMP9
21	vitamin b1232	9.7	BHMT, MTRR, MTHFR, MTR, CD79A, CCL2
22	thymidylate32	9.7	MTRR, MTHFR, MTR, MTHFD1, CDH1, FPGS
23	glutamate32	9.5	UCP1, MTRR, MTHFR, MTR, FYN, CD79A
24	ribonucleic acid32	9.5	BMP4, BMP7, RARA, UCP1, MMP1, MMP3
25	thymidine32 18	10.3	BMP4, BMP7, RARA, MTHFR, FPGS, FGA
26	h2o232	9.3	UCP1, FYN, CD79A, FGFR2, CBS, PTPN3
27	vitamin d32	9.3	BMP7, RARA, MTHFR, CD79A, CDH1, ITGB3
28	phosphatidylinositol32	9.3	BMP4, RARA, UCP1, FYN, CDH2, CDH1
29	ly29400232	9.3	RARA, CDH1, MMP9, CCL2, ERBB2, TLR4
30	folate32	9.3	RARA, BHMT, MTRR, MTHFR, MTR, MTHFD1
31	5fluorouracil32	9.1	MTHFR, CDH1, FPGS, GSTM1, GSTP1, FGF7
32	pd 98,05932	9.0	BMP4, RARA, CDH1, MMP1, MMP3, MMP9
33	arginine32	8.9	RFC1, RARA, LIPC, CD79A, GSTT1, FGF1
34	paraffin32	8.9	CD79A, GSTP1, EGFR, TIMP2, TGFB1
35	methotrexate32 34 42 9 9	12.7	MTRR, MTHFR, MTR, CD79A, CDH1, MMP1
36	oligonucleotide32	8.6	BMP4, RARA, MSX2, CDH2, MMP1, FOXO3
37	genistein32 9 18 9	11.6	FYN, CDH2, CDH1, MMP1, MMP3, MMP9
38	cycloheximide32	8.2	BMP4, BMP7, RARA, FYN, MMP1, MMP3
39	alanine32	8.1	RFC1, RARA, UCP1, MTRR, MTHFR, FYN
40	dexamethasone32 42 34 9 9	12.0	BMP4, BMP7, RARA, PAPPA, SCD5, CD79A
41	creatinine32	7.9	BMP7, PAPPA, MTHFR, MTR, CD79A, CDH1
42	cyclosporin a32 42	8.8	BMP4, LIPC, MTHFR, FYN, CD79A, MMP1
43	estrogen32	7.6	BMP4, BMP7, RARA, LIPC, MTHFR, MTR
44	heparin32 9 18 9	INF	BMP4, LIPC, PAPPA, , CD79A, CDH1
45	testosterone32 9 18 9	INF	RARA, LIPC, UCP1, MTHFR, CD79A, CDH2
46	steroid32	INF	LMX1B, RARA, LIPC, PAPPA, MSX2,
47	cysteine32	INF	BMP4, RARA, PAPPA, UCP1, MTHFR, MTR
48	retinoic acid32 42 18	INF	BMP4, BMP7, RARA, UCP1, MTHFR, MSX1
49	vegf32	INF	BMP4, BMP7, PAPPA, FYN, CDH2, CDH1
50	calcium32 9 18 9	INF	BSPRY, BMP4, BMP7, RARA, LIPC, PAPPA

Cellular components related to cleft lip according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	PDGFRA, PDSS2, SKI, EDN1, EGFR, AHCY
2	cell surface	GO:009986	8.5	TGFB2, TGFB3, TGFBR3, PVRL2, WNT3A, WNT5A
3	proteinaceous extracellular matrix	GO:005578	INF	BMP4, TGFBR3, WNT11, WNT3, WNT3A, WNT5A
4	extracellular region	GO:005576	INF	COL27A1, RSPO3, NOG, CRISPLD2, CRISPLD1, CRB2
5	extracellular space	GO:005615	INF	TGFA, EGFR, EDN1, NOG, TNC, CCL2

Biological processes related to cleft lip according to GeneDecks:

(show top 50)    (show all 73)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to retinoic acid	GO:071300	11.0	FZD7, OSR1, WNT11, WNT3, WNT3A, WNT5A
2	odontogenesis of dentin-containing tooth	GO:042475	11.0	TP63, GLI2, FGF10, JAG2, MSX1, LHX8
3	methionine biosynthetic process	GO:009086	11.0	MTHFD1, MTHFR, MTRR, BHMT2, BHMT
4	hair follicle morphogenesis	GO:031069	10.9	TGFB2, TP63, FGFR2, FGF7, FGF10, FOXE1
5	embryonic limb morphogenesis	GO:030326	10.9	PRRX1, SKI, PTCH1, TP63, GREM1, FGFR1
6	middle ear morphogenesis	GO:042474	10.8	PRRX1, OSR1, EDN1, NOG, FGFR1, MSX1
7	embryonic cranial skeleton morphogenesis	GO:048701	10.8	WNT9B, PRRX1, TFAP2A, TGFBR1, TWIST1, PDGFRA
8	wound healing	GO:042060	10.7	WNT5A, TGFBR1, TGFB2, TGFA, PDGFRA, NOG
9	inner ear morphogenesis	GO:042472	10.6	EPHB2, PRRX1, TFAP2A, SPRY2, MAFB, FGFR2
10	embryonic forelimb morphogenesis	GO:035115	10.6	WNT7A, OSR1, TFAP2A, TWIST1, MSX2, MSX1
11	pituitary gland development	GO:021983	10.6	NOG, GLI2, FGF10, CDH1, BMPR1A, BMP4
12	in utero embryonic development	GO:001701	10.5	TWIST1, TGFB3, TGFBR1, WNT3A, WNT9B, MYH9
13	skeletal system development	GO:001501	10.5	SOX4, TGFBR1, DSPP, NOG, TP63, GLI2
14	positive regulation of mesenchymal cell proliferation	GO:002053	10.5	PRRX1, TP63, FGFR2, FGFR1, FGF9, BMPR1A
15	palate development	GO:060021	10.5	VAX1, OSR1, PRRX1, WNT11, WNT3A, WNT5A
16	negative regulation of axon extension involved in axon guidance	GO:048843	10.4	WNT5A, WNT3A, WNT3, RYK
17	osteoblast differentiation	GO:001649	10.4	WNT3A, BMP4, MSX2, FGF9, GLI2, NOG
18	face morphogenesis	GO:060325	10.3	TGFB3, TGFB2, TGFB1, SKI, NOG, MSX1
19	ureteric bud development	GO:001657	10.3	OSR1, TCF21, TGFB1, FGFR2, FGFR1, BMP7
20	cartilage development	GO:051216	10.3	WNT7A, WNT5A, PRRX1, EDN1, NOG, SATB2
21	neuron differentiation	GO:030182	10.3	WNT9B, WNT5A, WNT3A, WNT3, WNT11, RYK
22	cellular response to growth factor stimulus	GO:071363	10.2	BMP4, PAX9, MSX2, FYN, TGFB1, TGFB3
23	response to estradiol stimulus	GO:032355	10.1	WNT5A, STAT5B, STAT3, TGFB2, TGFB1, FGF10
24	frontal suture morphogenesis	GO:060364	10.1	TGFB3, TGFB2, TGFB1, MSX2
25	positive regulation of SMAD protein import into nucleus	GO:060391	10.1	TGFBR1, TGFB3, TGFB1, BMPR1A, BMP4
26	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.0	NOG, SKI, EDN1, TWIST1, TGFB1, TGIF1
27	positive regulation of bone mineralization	GO:030501	10.0	OSR1, TFAP2A, TGFB3, TGFB1, BMPR1A, BMP7
28	epithelial to mesenchymal transition	GO:001837	10.0	WNT5A, TGFBR3, TGFBR1, TGFB2, TGFB1, NOG
29	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.0	TGFBR1, TGFB3, TGFB1, BMPR1A, BMP7, BMP4
30	pathway-restricted SMAD protein phosphorylation	GO:060389	9.9	TGFBR3, TGFBR1, TGFB2, TGFB1, BMP7
31	negative regulation of transcription, DNA-dependent	GO:045892	9.9	SUMO1, TGFB1, TFAP2A, RUNX2, SIX3, WNT11
32	negative regulation of apoptotic process	GO:043066	9.9	TGFB2, TFAP2A, OSR1, SOX4, WNT11, WNT5A
33	negative regulation of cell proliferation	GO:008285	9.8	TGIF1, TFAP2A, SOX4, TGFB3, TGFB2, TGFB1
34	positive regulation of transcription, DNA-dependent	GO:045893	9.7	PHF8, TGFB1, TGFB3, TGFBR1, TFAP2A, STAT3
35	positive regulation of epithelial cell proliferation	GO:050679	9.6	NOG, EGFR, TGFA, TGFB1, OSR1, ERBB2
36	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.5	TCF21, TFAP2A, TGFB3, TGFB1, TLR4, TWIST1
37	response to drug	GO:042493	8.8	GAD1, ADAM17, SLC12A5, STAT3, TGIF1, TGFB2
38	canonical Wnt receptor signaling pathway	GO:060070	INF	WNT8A, WNT7A, WNT5A, WNT3A, WNT3, WNT11
39	angiogenesis	GO:001525	INF	TGFA, TGFB2, , EPHB2, EPHB3, MYH9
40	axon guidance	GO:007411	INF	PVRL1, RYK, WNT3, WNT3A, WNT5A, EPHB2
41	positive regulation of cell division	GO:051781	INF	TGFA, TGFB1, TGFB2, TGFB3, FGFR2, FGF9
42	odontogenesis	GO:042476	INF	OSR1, TGFB3, TGFB2, ENAM, FGFR2,
43	embryonic hindlimb morphogenesis	GO:035116	INF	WNT7A, OSR1, TWIST1, , MSX2, MSX1
44	organ induction	GO:001759	INF	FGFR1, , FGF3, FGF10, FGF1
45	lung morphogenesis	GO:060425	INF	, SPRY2, NOG, TCF21, BMP4
46	positive regulation of cell proliferation	GO:008284	INF	EDN1, EGFR, TGFB1, TGFB2, TGFBR1, SOX4
47	mesonephros development	GO:001823	INF	OSR1, , FGF10, BMP7, BMP4
48	positive regulation of gene expression	GO:010628	INF	WNT3, WNT11, OSR1, TFAP2A, TGFB2, TGFB1
49	fibroblast growth factor receptor signaling pathway	GO:008543	INF	SPRY2, FGFR2, FGFR1, FGF9, , FGF7
50	BMP signaling pathway	GO:030509	INF	SKI, NOG, , BMPR1A, BMP7, BMP4

Molecular functions related to cleft lip according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	HEMGN, TWIST1, TLR4, TGFA, TGFB1, TGFB2
2	sequence-specific DNA binding	GO:043565	10.5	GLI2, TP73, DLX4, NR6A1, TGIF1, TFAP2A
3	homocysteine S-methyltransferase activity	GO:008898	10.5	BHMT, BHMT2, MTR
4	sequence-specific DNA binding transcription factor activity	GO:003700	10.4	DLX4, DLX3, TBX22, TBX10, TP73, TGIF1
5	frizzled binding	GO:005109	10.3	WNT8A, WNT5A, WNT3, RYK, RSPO3
6	receptor agonist activity	GO:048018	10.3	WNT8A, WNT7A, WNT5A, WNT3A, WNT3, GREM1
7	type II transforming growth factor beta receptor binding	GO:005114	10.0	TGFBR3, TGFBR1, TGFB3, TGFB2, TGFB1
8	type 2 fibroblast growth factor receptor binding	GO:005111	INF	, FGF7, FGF18, FGF10
9	heparin binding	GO:008201	INF	TGFBR3, RSPO3, CRISPLD2, CCL2, FGFR2, FGFR1
10	protein tyrosine kinase activity	GO:004713	INF	EPHB2, , RYK, EGFR, ERBB2, FGFR2
11	growth factor activity	GO:008083	INF	BMP4, TGFB3, TGFB2, TGFB1, TGFA, MANF
12	protein homodimerization activity	GO:042803	INF	NOG, PDGFRA, TWIST1, TGFB1, TGFB2, TFAP2A