Aliases & Classifications for Cleft Lip

Aliases & Descriptions for Cleft Lip:

Name: Cleft Lip 12 52 42 14
Cleft Lip, Unilateral, Complete 12
Complete Unilateral Cleft Lip 12
Labium Leporinum 12
Cheiloschisis 12
Hare Lip 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9296
ICD10 33 Q36 Q36.9
MeSH 42 D002971
NCIt 47 C87175

Summaries for Cleft Lip

MalaCards based summary : Cleft Lip, also known as cleft lip, unilateral, complete, is related to orofacial cleft 6 and fibrous dysplasia. An important gene associated with Cleft Lip is CLPTM1 (CLPTM1, Transmembrane Protein), and among its related pathways/superpathways are Pathways in cancer and Wnt / Hedgehog / Notch. The drugs Sevoflurane and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and skin, and related phenotypes are growth/size/body region and craniofacial

Related Diseases for Cleft Lip

Diseases related to Cleft Lip via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)
id Related Disease Score Top Affiliating Genes
1 orofacial cleft 6 32.6 IRF6 SATB2 TP63
2 fibrous dysplasia 29.6 IRF6 MSX1 MTHFR SATB2 TGFB3 TP63
3 cleft lip/palate 12.5
4 cleft lip/palate-ectodermal dysplasia syndrome 12.4
5 cleft lip +/- cleft palate 12.3
6 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.2
7 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.2
8 isolated cleft lip 12.1
9 cleft lip and alveolus 12.1
10 median cleft lip/mandibule 12.0
11 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.0
12 orofacial cleft 11 12.0
13 hay-wells syndrome 11.9
14 cleft lip/palate with abnormal thumbs and microcephaly 11.9
15 ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 1 11.9
16 coloboma, cleft lip/palate and mental retardation syndrome 11.9
17 polydactyly cleft lip palate psychomotor retardation 11.9
18 van der woude syndrome 11.9
19 eec syndrome 11.9
20 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 11.9
21 microcephaly, corpus callosum dysgenesis and cleft lip-palate 11.9
22 cleft lip, congenital healed 11.9
23 amelia cleft lip palate hydrocephalus iris coloboma 11.8
24 anophthalmia cleft lip palate hypothalamic disorder 11.8
25 cleft lip and palate malrotation cardiopathy 11.8
26 cleft lip and/or palate with mucous cysts of lower 11.8
27 cleft lip palate dysmorphism kumar type 11.8
28 cleft lip palate mental retardation corneal opacity 11.8
29 cleft lip palate oligodontia syndactyly pili torti 11.8
30 cleft lip palate pituitary deficiency 11.8
31 cleft lip palate-tetraphocomelia 11.8
32 craniosynostosis cleft lip palate arthrogryposis 11.8
33 holoprosencephaly ectrodactyly cleft lip palate 11.8
34 lagophthalmia cleft lip palate 11.8
35 microbrachycephaly ptosis cleft lip 11.8
36 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 11.8
37 syndactyly ectodermal dysplasia cleft lip palate hand foot 11.8
38 tibial hemimelia cleft lip palate 11.8
39 cleft lip/palate-deafness-sacral lipoma syndrome 11.8
40 cleft lip-retinopathy syndrome 11.8
41 auriculoocular anomalies-cleft lip syndrome 11.8
42 auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome 11.8
43 rapp-hodgkin syndrome 11.8
44 roberts syndrome 11.7
45 hartsfield syndrome 11.7
46 popliteal pterygium syndrome 1 11.6
47 orofacial cleft 5 11.6
48 orofacial cleft 10 11.6
49 vici syndrome 11.6
50 blepharocheilodontic syndrome 11.6

Graphical network of the top 20 diseases related to Cleft Lip:



Diseases related to Cleft Lip

Symptoms & Phenotypes for Cleft Lip

MGI Mouse Phenotypes related to Cleft Lip:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.35 BMP4 FGFR1 IRF6 MID1 MSX1 MTHFR
2 craniofacial MP:0005382 10.3 BMP4 FGFR1 IRF6 MSX1 NECTIN1 PAX9
3 digestive/alimentary MP:0005381 10.25 TGFB3 TP63 BMP4 FGFR1 IRF6 MSX1
4 mortality/aging MP:0010768 10.21 MTR NECTIN1 PAX9 RARA SATB2 TBX10
5 embryo MP:0005380 10.19 BMP4 FGFR1 IRF6 MID1 MSX1 PAX9
6 limbs/digits/tail MP:0005371 10.1 BMP4 FGFR1 IRF6 MSX1 MTHFR PAX9
7 integument MP:0010771 10.09 BMP4 FGFR1 IRF6 MSX1 MTHFR NECTIN1
8 hearing/vestibular/ear MP:0005377 10 BMP4 FGFR1 IRF6 MSX1 PAX9 RARA
9 muscle MP:0005369 9.92 BMP4 FGFR1 MID1 MSX1 PAX9 RARA
10 normal MP:0002873 9.86 BMP4 FGFR1 MID1 PAX9 RARA TBX10
11 respiratory system MP:0005388 9.7 BMP4 MSX1 PAX9 RARA SATB2 TGFB3
12 skeleton MP:0005390 9.7 RARA SATB2 TGFA TGFB3 TP63 BMP4
13 vision/eye MP:0005391 9.32 FGFR1 MSX1 MTHFR NECTIN1 RARA TBX10

Drugs & Therapeutics for Cleft Lip

Drugs for Cleft Lip (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4 Anti-Infective Agents Phase 4,Phase 2,Phase 1
5 Anesthetics Phase 4,Phase 2,Phase 3
6 Anesthetics, General Phase 4,Phase 2,Phase 3
7 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3
8 Anti-Bacterial Agents Phase 4,Phase 1
9 Antibiotics, Antitubercular Phase 4,Phase 1
10 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
11 Anesthetics, Inhalation Phase 4
12 Hypnotics and Sedatives Phase 4
13 Platelet Aggregation Inhibitors Phase 4
14 Antitubercular Agents Phase 4
15
Acetylcholine Approved Phase 3,Phase 1,Phase 2 51-84-3 187
16
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
17
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
18
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
19
Levobupivacaine Approved Phase 2, Phase 3 27262-47-1 92253
20
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
22 Cholinergic Agents Phase 3,Phase 1,Phase 2
23 Neuromuscular Agents Phase 3,Phase 1,Phase 2
24 Neurotransmitter Agents Phase 3,Phase 2,Phase 1
25 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
26 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
27 incobotulinumtoxinA Phase 3,Phase 1,Phase 2
28 onabotulinumtoxinA Phase 3,Phase 1,Phase 2
29 Liver Extracts Phase 3,Phase 2,Phase 1
30 Botulinum Toxins Phase 3,Phase 1,Phase 2
31 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2
32 pancreatic polypeptide Phase 3
33 Analgesics Phase 2, Phase 3
34 Adjuvants, Anesthesia Phase 3
35 Narcotics Phase 3
36 Hematinics Phase 3
37 Trace Elements Phase 3
38 Analgesics, Opioid Phase 3
39 Anesthetics, Dissociative Phase 2, Phase 3
40 Anesthetics, Local Phase 2, Phase 3
41 Vitamin B Complex Phase 3
42 Vitamins Phase 3
43 Excitatory Amino Acid Antagonists Phase 2, Phase 3
44 Excitatory Amino Acids Phase 2, Phase 3
45 Micronutrients Phase 3
46 Cola Nutraceutical Phase 3,Phase 2,Phase 1
47 Folate Nutraceutical Phase 3
48 Vitamin B9 Nutraceutical Phase 3
49
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
50
Indinavir Approved Phase 2 150378-17-9 5362440

Interventional clinical trials:

(show top 50) (show all 65)
id Name Status NCT ID Phase
1 The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair Recruiting NCT02688634 Phase 4
2 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4
3 Botulinum Toxin to Improve Results in Cleft Lip Repair Unknown status NCT01429402 Phase 3
4 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811 Phase 2, Phase 3
5 Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery. Completed NCT02514980 Phase 2, Phase 3
6 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3
7 Oral Cleft Prevention Program Completed NCT00397917 Phase 3
8 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3
9 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
10 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2
11 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
12 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
13 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2
14 Effect of Platelet Rich Plasma (PRP) on the Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair Not yet recruiting NCT02958306 Phase 2
15 Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer Completed NCT00045006 Phase 1
16 Motexafin Gadolinium and Doxorubicin in Treating Patients With Advanced Cancer Completed NCT00036790 Phase 1
17 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1
18 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1
19 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Unknown status NCT01932164
20 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726
21 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998
22 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
23 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623
24 FaceBase Biorepository Unknown status NCT01252264
25 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
26 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714
27 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
28 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
29 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
30 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509
31 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540
32 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
33 Tympanometric Analysis in Cleft Palate Completed NCT01820689
34 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
35 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
36 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
37 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
38 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
39 Child's Adipose Cells: Capacity of Tissue Regeneration Completed NCT02779205
40 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
41 Sleep and Behavior in Children With Cleft Palate Completed NCT01046591
42 Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population Completed NCT00341068
43 Child and Infant Learning Project Completed NCT00077831
44 Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer Completed NCT00002520
45 Study of Previously Collected and Stored Tissue Samples From Patients Previously Enrolled in a Completed National Cancer Institute Clinical Trial Completed NCT00904514
46 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
47 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Recruiting NCT03029195
48 Follow Ups of Parents With Infants With Cleft Lip and Palate Recruiting NCT02415361
49 Biochemical and Histological Comparison of Nasal and Auricular Cartilage in the Fetus and Newborn With Cleft Lip Carrier Recruiting NCT02505360
50 Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants Recruiting NCT02845193

Search NIH Clinical Center for Cleft Lip

Cochrane evidence based reviews: cleft lip

Genetic Tests for Cleft Lip

Anatomical Context for Cleft Lip

MalaCards organs/tissues related to Cleft Lip:

39
Bone, Heart, Skin, Kidney, Breast, Brain, Pituitary

Publications for Cleft Lip

Articles related to Cleft Lip:

(show top 50) (show all 1134)
id Title Authors Year
1
Imputation of Orofacial Clefting Data Identifies Novel Risk Loci and Sheds Light on the Genetic Background of Cleft Lip A+ Cleft Palate and Cleft Palate Only. ( 28087736 )
2017
2
Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. ( 28054174 )
2017
3
Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients After Primary Cheiloplasty Without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. ( 28085515 )
2017
4
International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome instrument for children and young adults with cleft lip and/or palate (CLEFT-Q). ( 28077415 )
2017
5
Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. ( 28069795 )
2017
6
Polymorphic variants in VAX1 and the risk of nonsyndromic cleft lip with or without cleft palate in a population from northern China. ( 28383424 )
2017
7
Evaluation of lip force in patients with unilateral and bilateral cleft lip. ( 28087210 )
2017
8
Assessment of complete unilateral cleft lip and palate patients: Determination of factors effecting dental arch relationships. ( 28012538 )
2017
9
Association of single-nucleotide polymorphisms of CDH1 with nonsyndromic cleft lip with or without cleft palate in a northern Chinese Han population. ( 28151848 )
2017
10
Dynamic facial asymmetry in patients with repaired cleft lip using 4D imaging (video stereophotogrammetry). ( 28011182 )
2017
11
Skoog Primary Periosteoplasty versus Secondary Alveolar Bone Grafting in Unilateral Cleft Lip and Alveolus: Long-Term Effects on Alveolar Bone Formation and Maxillary Growth. ( 28027239 )
2017
12
Comparing Modified Huddart-Bodenham Scoring System and GOSLON Yardstick to Assess Dental Arch Relationships in Unilateral Cleft Lip and Palate Patients. ( 28092164 )
2017
13
Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate. ( 27604992 )
2016
14
Decolonisation of meticillin-resistant Staphylococcus aureus (MRSA) carriage in adopted children with cleft lip and palate. ( 27563747 )
2016
15
Columellar Reconstruction: A New Technique for Median Cleft Lip Repair. ( 28005651 )
2016
16
Reply to the Letters to the Editor Concerning the Article: Ana Isabel Costa, HAclder Morgado, Carlos Mariz, JosAc Manuel EstevALo-Costa. Secondary Alveolar Grafting and Cleft Lip and Palate. Acta Med Port 2016;29:210-6. ( 27649024 )
2016
17
Phonology in Swedish-speaking 5-year-olds born with unilateral cleft lip and palate and the relationship with consonant production at 3 years of age. ( 27172850 )
2016
18
Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model. ( 27927890 )
2016
19
Unfavorable outcome of unilateral cleft lip repair. ( 27563597 )
2016
20
Cleft sidedness and congenitally missing teeth in patients with cleft lip and palate patients. ( 27135068 )
2016
21
Identification of Novel Variants in the PVRL1 Gene in Patients With Nonsyndromic Cleft Lip With or Without Cleft Palate. ( 26953873 )
2016
22
Digital Three-Dimensional Automation of the Modified Huddart and Bodenham Scoring System for Patients With Cleft Lip and Palate. ( 27136074 )
2016
23
Presurgical Nasoalveolar Molding Therapy Using Figueroa's NAM Technique in Unilateral Cleft Lip and Palate Patients: A Preliminary Study. ( 27617383 )
2016
24
Presurgical nasoalveolar moulding: A boon in the management of cleft lip and palate. ( 28050103 )
2016
25
Asymmetric Dental Development Investigated by Cone-Beam Computed Tomography in Patients With Unilateral Cleft Lip and Alveolus. ( 26274901 )
2016
26
Survey of Parent Experiences in Prenatal Visits for Infants With Cleft Lip and Palate. ( 27632760 )
2016
27
Comparison of dental arch dimensions in models of preschool children with cleft lip/palate repaired by means of surgery alone versus controls. ( 27749647 )
2016
28
Measuring Symmetry in Children With Cleft Lip. Part 3: Quantifying Nasal Symmetry and Nasal Normalcy Before and After Unilateral Cleft Lip Repair. ( 27580380 )
2016
29
Computer-Assisted Orthognathic Surgery for Patients with Cleft Lip/Palate: From Traditional Planning to Three-Dimensional Surgical Simulation. ( 27002726 )
2016
30
Preliminary Analysis of the 3-Dimensional Morphology of the Upper Lip Configuration at the Completion of Facial Expressions in Healthy Japanese Young Adults and Patients With Cleft Lip. ( 27129635 )
2016
31
MSX1 gene polymorphisms in Mexican patients with non-syndromic cleft lip/palate. ( 27729116 )
2016
32
Suboptimal Performance in Cleft Lip/Palate Children- Who is Responsible? ( 27891420 )
2016
33
Association of MSX1 c.*6Ca88>a88T Variant with Nonsyndromic Cleft Lip With or Without Cleft Palate in Turkish Patients. ( 27228008 )
2016
34
MTR, MTRR, and MTHFR Gene Polymorphisms and Susceptibility to Nonsyndromic Cleft Lip With or Without Cleft Palate. ( 27167580 )
2016
35
Assessing Angle's malocclusion among cleft lip and/or palate patients in Jammu. ( 27195223 )
2016
36
Fordyce Happiness Program and Happiness in Mothers of Children with a Cleft Lip and Palate. ( 28008390 )
2016
37
Discussion on: Nasoalveolar Molding Therapy for the Treatment of Unilateral Cleft Lip and Palate Improves Nasal Symmetry and Maxillary Alveolar Dimensions. ( 28005738 )
2016
38
Gene Interactions Provide Evidence for Signaling Pathways Involved in Cleft Lip/Palate in Humans. ( 27154735 )
2016
39
Rescue of lip switch flap at risk of necrosis due to venous congestion for cleft lip deformity. ( 27583269 )
2016
40
Modified Activation Technique for Nasal Stent of Nasoalveolar Molding Appliance for Columellar Lengthening in Bilateral Cleft Lip/Palate. ( 27002917 )
2016
41
Time trend of incidence rates of cleft lip/palate in Taiwan from 1994 to 2013. ( 27372171 )
2016
42
The Slav-cleft: A three-center study of the outcome of treatment of cleft lip and palate. Part 1: Craniofacial morphology. ( 27663676 )
2016
43
Quantitative assessment of healthy and reconstructed cleft lip using ultrasonography. ( 27134448 )
2016
44
Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate. ( 26692521 )
2016
45
Parental experience caring for cleft lip and palate infants with nasoalveolar moulding. ( 27144651 )
2016
46
The Role of the Velopharyngeal Sphincter in the Speech of Patients with Cleft Palate or Cleft Lip and Palate Using Perceptual Methods. ( 28028412 )
2016
47
Three-dimensional Printing of Models of Cleft Lip and Palate. ( 27200251 )
2016
48
Management of feeding Problem in a Patient with Cleft Lip/Palate. ( 27365936 )
2016
49
Recurrence of split hand/foot malformation, cleft lip/palate, and severe urogenital abnormalities due to germline mosaicism for TP63 mutation. ( 27351625 )
2016
50
Novel variant in the TP63 gene associated to ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome. ( 27485918 )
2016

Variations for Cleft Lip

Expression for Cleft Lip

Search GEO for disease gene expression data for Cleft Lip.

Pathways for Cleft Lip

GO Terms for Cleft Lip

Biological processes related to Cleft Lip according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.91 BMP4 IRF6 MSX1 RARA TGFB3
2 BMP signaling pathway GO:0030509 9.8 BMP4 MSX1 TGFB3
3 positive regulation of neuron differentiation GO:0045666 9.79 BMP4 FGFR1 RARA
4 palate development GO:0060021 9.77 MSX1 SATB2 TGFB3
5 cartilage development GO:0051216 9.74 BMP4 MSX1 SATB2
6 odontogenesis of dentin-containing tooth GO:0042475 9.67 BMP4 MSX1 TP63
7 camera-type eye morphogenesis GO:0048593 9.65 BMP4 NECTIN1
8 middle ear morphogenesis GO:0042474 9.65 FGFR1 MSX1
9 folic acid metabolic process GO:0046655 9.65 MTHFR MTRR
10 anatomical structure formation involved in morphogenesis GO:0048646 9.64 BMP4 TP63
11 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.63 BMP4 MSX1
12 keratinocyte proliferation GO:0043616 9.61 IRF6 TP63
13 positive regulation of SMAD protein import into nucleus GO:0060391 9.6 BMP4 TGFB3
14 organ induction GO:0001759 9.58 BMP4 FGFR1
15 smooth muscle tissue development GO:0048745 9.58 BMP4 TP63
16 methionine biosynthetic process GO:0009086 9.56 MTR MTRR
17 salivary gland morphogenesis GO:0007435 9.55 FGFR1 TGFB3
18 prostate gland development GO:0030850 9.54 RARA TP63
19 ureteric bud development GO:0001657 9.54 BMP4 FGFR1 RARA
20 sulfur amino acid metabolic process GO:0000096 9.48 MTR MTRR
21 BMP signaling pathway involved in heart development GO:0061312 9.43 BMP4 MSX1
22 methionine metabolic process GO:0006555 9.4 MTHFR MTRR
23 face morphogenesis GO:0060325 9.33 MSX1 PAX9 TGFB3
24 regulation of odontogenesis GO:0042481 9.32 MSX1 PAX9
25 cloacal septation GO:0060197 9.26 BMP4 TP63
26 embryonic limb morphogenesis GO:0030326 9.26 BMP4 FGFR1 MSX1 TP63
27 odontogenesis GO:0042476 8.92 BMP4 MSX1 PAX9 TGFB3
28 positive regulation of transcription, DNA-templated GO:0045893 10.04 BMP4 IRF6 RARA TGFB3 TP63
29 negative regulation of transcription, DNA-templated GO:0045892 10.03 BMP4 MSX1 PAX9 RARA TP63
30 negative regulation of apoptotic process GO:0043066 10.02 BMP4 MSX1 RARA TGFA TP63
31 negative regulation of transcription from RNA polymerase II promoter GO:0000122 10 BMP4 FGFR1 MSX1 RARA SATB2 TP63
32 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10 BMP4 MSX1 PAX9 RARA SATB2 TGFB3

Molecular functions related to Cleft Lip according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulatory region DNA binding GO:0000975 8.62 IRF6 RARA

Sources for Cleft Lip

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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