Aliases & Classifications for Cleft Lip

MalaCards integrated aliases for Cleft Lip:

Name: Cleft Lip 12 72 51 41 14
Cleft Lip, Unilateral, Complete 12
Complete Unilateral Cleft Lip 12
Labium Leporinum 12
Cheiloschisis 12
Hare Lip 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9296
ICD10 32 Q36 Q36.9
MeSH 41 D002971
NCIt 46 C87175

Summaries for Cleft Lip

MalaCards based summary : Cleft Lip, also known as cleft lip, unilateral, complete, is related to cleft lip and alveolus and isolated cleft lip. An important gene associated with Cleft Lip is MSX1 (Msh Homeobox 1), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Sevoflurane and Propofol have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Cleft lip and cleft palate, also known as orofacial cleft, is a group of conditions that includes cleft... more...

Related Diseases for Cleft Lip

Diseases related to Cleft Lip via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 363)
# Related Disease Score Top Affiliating Genes
1 cleft lip and alveolus 33.8 IRF6 MSX1 NECTIN1 TP63
2 isolated cleft lip 33.5 IRF6 MSX1 NECTIN1 TBX10 TP63
3 van der woude syndrome 1 33.0 GRHL3 IRF6 TFAP2A
4 popliteal pterygium syndrome 32.8 GRHL3 IRF6 TFAP2A
5 branchiooculofacial syndrome 32.2 GRHL3 TFAP2A
6 cleft lip/palate 32.2 ARHGAP29 BMP4 DLX4 FGFR1 IRF6 MID1
7 cleft palate, isolated 30.9 ARHGAP29 BMP4 FGFR1 GRHL3 IRF6 MSX1
8 tooth size 29.9 BMP4 MSX1
9 split hand-foot malformation 29.7 FGFR1 SUMO1 TP63
10 tooth agenesis 29.7 BMP4 FGFR1 IRF6 MSX1 SUMO1 TGFA
11 orofacial cleft 26.2 ARHGAP29 BMP4 CLPTM1 CLPTM1L DLX4 FGFR1
12 cleft lip/palate-ectodermal dysplasia syndrome 12.5
13 ankyloblepharon-ectodermal defects-cleft lip/palate 12.5
14 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 12.5
15 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.4
16 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.3
17 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.3
18 polydactyly cleft lip palate psychomotor retardation 12.2
19 brachial amelia, cleft lip, and holoprosencephaly 12.2
20 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.1
21 uveal coloboma-cleft lip and palate-intellectual disability 12.1
22 microbrachycephaly ptosis cleft lip 12.1
23 median cleft lip/mandibule 12.1
24 cleft lip/palate with abnormal thumbs and microcephaly 12.0
25 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.0
26 cleft lip-retinopathy syndrome 12.0
27 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.0
28 radius, aplasia of, with cleft lip/palate 11.9
29 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 11.9
30 amelia cleft lip palate hydrocephalus iris coloboma 11.9
31 anophthalmia cleft lip palate hypothalamic disorder 11.9
32 cleft lip and palate malrotation cardiopathy 11.9
33 cleft lip and/or palate with mucous cysts of lower 11.9
34 cleft lip palate dysmorphism kumar type 11.9
35 cleft lip palate oligodontia syndactyly pili torti 11.9
36 cleft lip palate pituitary deficiency 11.9
37 cleft lip palate-tetraphocomelia 11.9
38 craniosynostosis cleft lip palate arthrogryposis 11.9
39 holoprosencephaly ectrodactyly cleft lip palate 11.9
40 lagophthalmia cleft lip palate 11.9
41 syndactyly ectodermal dysplasia cleft lip palate hand foot 11.9
42 tibial hemimelia cleft lip palate 11.9
43 cleft lip/palate-deafness-sacral lipoma syndrome 11.9
44 auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome 11.9
45 zlotogora syndrome 11.9
46 rapp-hodgkin syndrome 11.9
47 blepharocheilodontic syndrome 1 11.9
48 roberts syndrome 11.9
49 orofacial cleft 11 11.8
50 hartsfield syndrome 11.8

Graphical network of the top 20 diseases related to Cleft Lip:



Diseases related to Cleft Lip

Symptoms & Phenotypes for Cleft Lip

GenomeRNAi Phenotypes related to Cleft Lip according to GeneCards Suite gene sharing:

25 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 FGFR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.78 IRF6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.78 IRF6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.78 FGFR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.78 FGFR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.78 TFAP2A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.78 TFAP2A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 TGFA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 FGFR1 IRF6 TFAP2A TGFA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.78 IRF6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.78 TFAP2A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.78 FGFR1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.78 TFAP2A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.78 TGFA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.78 TFAP2A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.78 IRF6 TFAP2A FGFR1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.78 FGFR1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.78 FGFR1 TFAP2A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.78 IRF6
20 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.78 TFAP2A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 FGFR1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.78 FGFR1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 TGFA

MGI Mouse Phenotypes related to Cleft Lip:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.31 GRHL3 IRF6 MSX1 NECTIN1 SUMO1 TBX10
2 growth/size/body region MP:0005378 10.31 BMP4 FGFR1 GRHL3 IRF6 MID1 MSX1
3 digestive/alimentary MP:0005381 10.26 BMP4 FGFR1 GRHL3 IRF6 MSX1 SUMO1
4 behavior/neurological MP:0005386 10.21 BMP4 FGFR1 GRHL3 MID1 MSX1 NECTIN1
5 embryo MP:0005380 10.11 BMP4 FGFR1 GRHL3 IRF6 TGFB3 TP63
6 integument MP:0010771 10.11 BMP4 FGFR1 GRHL3 IRF6 MSX1 MTHFR
7 mortality/aging MP:0010768 10.1 BMP4 FGFR1 GRHL3 IRF6 MID1 MSX1
8 limbs/digits/tail MP:0005371 9.97 BMP4 FGFR1 GRHL3 IRF6 MSX1 MTHFR
9 hearing/vestibular/ear MP:0005377 9.88 BMP4 FGFR1 IRF6 MSX1 TBX10 TFAP2A
10 normal MP:0002873 9.85 MID1 MSX1 SUMO1 TBX10 TFAP2A TGFB3
11 skeleton MP:0005390 9.73 BMP4 FGFR1 GRHL3 IRF6 TFAP2A TGFA
12 vision/eye MP:0005391 9.4 TBX10 TFAP2A TGFA TGFB3 TP63 VAX1

Drugs & Therapeutics for Cleft Lip

Drugs for Cleft Lip (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
4 Anesthetics Phase 4,Phase 2,Phase 3
5 Anesthetics, General Phase 4,Phase 2,Phase 3
6 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3
7 Anesthetics, Inhalation Phase 4
8 Hypnotics and Sedatives Phase 4,Phase 2
9 Platelet Aggregation Inhibitors Phase 4
10
Acetylcholine Approved Phase 3,Phase 1,Phase 2 51-84-3 187
11
Bupivacaine Approved, Investigational Phase 2, Phase 3 38396-39-3, 2180-92-9 2474
12
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
13
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
15 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
16 Cholinergic Agents Phase 3,Phase 1,Phase 2
17 Neuromuscular Agents Phase 3,Phase 1,Phase 2
18 Neurotransmitter Agents Phase 3,Phase 2,Phase 1
19 onabotulinumtoxinA Phase 3,Phase 1,Phase 2
20 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
21 Botulinum Toxins Phase 3,Phase 1,Phase 2
22 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2
23 Analgesics Phase 2, Phase 3
24 Micronutrients Phase 3
25 Trace Elements Phase 3
26 Hematinics Phase 3
27 Anesthetics, Dissociative Phase 2, Phase 3
28 Vitamin B Complex Phase 3
29 Anesthetics, Local Phase 2, Phase 3
30 Vitamins Phase 3
31 Excitatory Amino Acid Antagonists Phase 2, Phase 3
32 Excitatory Amino Acids Phase 2, Phase 3
33 Folate Nutraceutical Phase 3
34 Vitamin B9 Nutraceutical Phase 3
35
Acetaminophen Approved Phase 2 103-90-2 1983
36
Dexmedetomidine Approved, Vet_approved Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
37 Adrenergic Agents Phase 2
38 Adrenergic Agonists Phase 2
39 Adrenergic alpha-2 Receptor Agonists Phase 2
40 Adrenergic alpha-Agonists Phase 2
41 Analgesics, Non-Narcotic Phase 2
42 Antipyretics Phase 2
43
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759
44
Morphine Approved, Investigational 57-27-2 5288826
45
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
46
Adenosine Approved, Investigational 58-61-7 60961
47 Daminozide 1596-84-5
48 Adjuvants, Immunologic
49 Viscosupplements
50 Protective Agents

Interventional clinical trials:

(show top 50) (show all 61)

# Name Status NCT ID Phase Drugs
1 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
2 Botulinum Toxin to Improve Results in Cleft Lip Repair Unknown status NCT01429402 Phase 3 Botulinum Toxin Type A;Botulinum Type A;Normal Saline;Normal Saline
3 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
4 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811 Phase 2, Phase 3
5 Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery. Completed NCT02514980 Phase 2, Phase 3 Bupivacaine;Ketamine
6 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
7 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
8 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
9 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
10 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
11 Suprazygomatic Block in Cleft Palate Surgery in Children Recruiting NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
12 Effect of Platelet Rich Plasma (PRP) on the Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair Not yet recruiting NCT02958306 Phase 2
13 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726
14 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998
15 Biochemical and Histological Comparison of Nasal and Auricular Cartilage in the Fetus and Newborn With Cleft Lip Carrier Unknown status NCT02505360
16 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
17 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623
18 FaceBase Biorepository Unknown status NCT01252264
19 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
20 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714
21 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
22 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164
23 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
24 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
25 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
26 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509
27 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 MORPHINE PLUS FENTANYL;Fentanyl
28 Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations Completed NCT03395015
29 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
30 Tympanometric Analysis in Cleft Palate Completed NCT01820689
31 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
32 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
33 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
34 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
35 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
36 Child's Adipose Cells: Capacity of Tissue Regeneration Completed NCT02779205
37 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
38 Sleep and Behavior in Children With Cleft Palate Completed NCT01046591
39 Child and Infant Learning Project Completed NCT00077831
40 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
41 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Recruiting NCT03029195
42 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Recruiting NCT02881606
43 Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants Recruiting NCT02845193
44 Evaluation of the Effect of Botulinum Toxin Type-A Injection Prior to Surgical Correction of Complete Unilateral Cleft Lip Repair by Modified Millard Cheiloplasty Recruiting NCT03047499 Botulinum toxin type A
45 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
46 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686
47 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
48 Stentless Endoscopic Transnasal Transseptal Choanoplasty Recruiting NCT03167463
49 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207
50 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Recruiting NCT02900014

Search NIH Clinical Center for Cleft Lip

Cochrane evidence based reviews: cleft lip

Genetic Tests for Cleft Lip

Anatomical Context for Cleft Lip

MalaCards organs/tissues related to Cleft Lip:

38
Bone, Heart, Skin, Thyroid, Breast, Kidney, Pituitary

Publications for Cleft Lip

Articles related to Cleft Lip:

(show top 50) (show all 1212)
# Title Authors Year
1
Evaluation of alveolar bone support around incisors in patients with unilateral cleft lip, alveolus, and palate in late mixed dentition using cone beam computed tomography. ( 29384701 )
2018
2
Effects of Nasoalveolar Molding Therapy on Alveolar and Palatal Cleft Deformities in Unilateral and Bilateral Cleft Lip and Palate. ( 29381641 )
2018
3
3D-Printed Models of Cleft Lip and Palate for Surgical Training and Patient Education. ( 29437509 )
2018
4
Association of CDKAL1 nucleotide variants with the risk of non-syndromic cleft lip with or without cleft palate. ( 29403086 )
2018
5
Tooth-borne distraction osteogenesis versus conventional Le Fort I in maxillary advancement of cleft lip and palate patients. ( 29388417 )
2018
6
Possible effect of SNAIL family transcriptional repressor 1 polymorphisms in non-syndromic cleft lip with or without cleft palate. ( 29374328 )
2018
7
Teeth agenesis evaluation in an Italian sample of complete unilateral and bilateral cleft lip and palate patients. ( 29388416 )
2018
8
What Matters to Patients With Cleft Lip and/or Palate: An International Qualitative Study Informing the Development of the CLEFT-Q. ( 29437508 )
2018
9
Minimally invasive versus standard approach in LeFort 1 osteotomy in patients with history of cleft lip and palate. ( 29408322 )
2018
10
Bone-anchored maxillary protraction in a patient with complete cleft lip and palate: A case report. ( 29407507 )
2018
11
Autologous Fat Grafting in the Treatment of Cleft Lip Volume Asymmetry. ( 29401128 )
2018
12
Longitudinal Study of Scar Hyperplasia Formation Following Cleft Lip Wound Healing. ( 29381621 )
2018
13
Cleft Lip and Palate in CHARGE Syndrome: Phenotypic Features That Influence Management. ( 29437513 )
2018
14
Rare Variant of Ankyloblepharon-ectodermal Defect-cleft Lip/Cleft Palate Syndrome: Curly Hair-ankyloblepharon-nail Disease Syndrome. ( 29440852 )
2018
15
Effectiveness of presurgical nasoalveolar molding therapy on unilateral cleft lip nasal deformity. ( 29436566 )
2018
16
PVR/CD155 Ala67Thr Mutation and Cleft Lip/Palate. ( 29381645 )
2018
17
Strong Association of C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene With Nosyndromic Cleft Lip/Palate (nsCL/P). ( 29371764 )
2018
18
Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis. ( 29274157 )
2018
19
A Pediatrician's Guide to Communication Disorders Secondary to Cleft Lip/Palate. ( 29173718 )
2018
20
Association of WNT Pathway Genes With Nonsyndromic Cleft Lip With or Without Cleft Palate. ( 29437498 )
2018
21
Association Between Cleft Lip and/or Cleft Palate and Family History of Cancer: A Case-Control Study. ( 29389703 )
2018
22
Dynamic facial asymmetry in patients with repaired cleft lip using 4D imaging (video stereophotogrammetry). ( 28011182 )
2017
23
Tooth agenesis code (TAC) in complete unilateral and bilateral cleft lip and palate patients. ( 29243181 )
2017
24
Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology. ( 29026689 )
2017
25
A Comparative Study of Oral Microbiota in Infants with Complete Cleft Lip and Palate or Cleft Soft Palate. ( 28393073 )
2017
26
Cleft Lip and Palate Repair: Our Experience. ( 28906329 )
2017
27
Outcomes of an International Volunteer Surgical Project for Patients with Cleft Lip and/or Cleft Palate: A Mission in Developing Laos. ( 28949405 )
2017
28
The association study of nonsyndromic cleft lip with or without cleft palate identified risk variants of the GLI3 gene in a Chinese population. ( 28947718 )
2017
29
Novel findings of left ventricular non-compaction cardiomyopathy, microform cleft lip and poor vision in patient with SMC1A-associated Cornelia de Lange syndrome. ( 28102598 )
2017
30
Patient and parent reported outcome measures in cleft lip and palate patients before and after secondary alveolar bone grafting. ( 29384973 )
2017
31
Policy on the Management of Patients with Cleft Lip/Palate and Other Craniofacial Anomalies. ( 29179385 )
2017
32
A Comparative Study of the Aesthetic Outcome of Two Techniques for Unilateral Complete Cleft Lip Repair. ( 28953726 )
2017
33
SIBLINGS AFFECTED BY ECTRODACTYLY-ECTODERMAL DYSPLASIA AND CLEFT LIP/PALATE (EEC) SYNDROME PRESENTING NORMAL PARENTS: GERMLINE MOSAICISM? ( 28977327 )
2017
34
The Smile Index Part 1: A Large-Scale Study of Phenotypic Norms for Pre- and Post-Operative Unilateral Cleft Lip. ( 28922326 )
2017
35
Imputation of Orofacial Clefting Data Identifies Novel Risk Loci and Sheds Light on the Genetic Background of Cleft Lip A+ Cleft Palate and Cleft Palate Only. ( 28087736 )
2017
36
Establishing Content Validity of the CLEFT-Q: A New Patient-reported Outcome Instrument for Cleft Lip/Palate. ( 28507866 )
2017
37
Common variants in DLG1 locus are associated with non-syndromic cleft lip with or without cleft palate. ( 28926086 )
2017
38
Discussion: A Comparative Study of the Aesthetic Outcome of Two Techniques for Unilateral Complete Cleft Lip Repair. ( 28953727 )
2017
39
Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate-Part 2: Relationship between root resorption, horizontal tooth movement, and quantity of grafted autogenous bone. ( 28906140 )
2017
40
Nucleotide variants of the NAT2 and EGF61 genes in patients in Northern China with nonsyndromic cleft lip with or without cleft palate. ( 28906376 )
2017
41
Cone beam computed tomography imaging of superior semicircular canal morphology: a retrospective comparison of cleft lip/palate patients and normal controls. ( 29202612 )
2017
42
Association studies of low-frequency coding variants in nonsyndromic cleft lip with or without cleft palate. ( 28425186 )
2017
43
Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. ( 28054174 )
2017
44
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome. ( 28230601 )
2017
45
Evaluation of lip force in patients with unilateral and bilateral cleft lip. ( 28087210 )
2017
46
Prenatal diagnosis of a 1.6-Mb 4p16.3 interstitial microdeletion encompassing FGFRL1 and TACC3 associated with bilateral cleft lip and palate of Wolf-Hirschhorn syndrome facial dysmorphism and short long bones. ( 29241927 )
2017
47
A Family With Craniofrontonasal Syndrome: The First Report of Familial Cases of Craniofrontonasal Syndrome With Bilateral Cleft Lip and Palate. ( 28140668 )
2017
48
Genitourinary malformations: an under-recognized feature of ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome. ( 28166087 )
2017
49
Association of single-nucleotide polymorphisms of CDH1 with nonsyndromic cleft lip with or without cleft palate in a northern Chinese Han population. ( 28151848 )
2017
50
Polymorphic variants in VAX1 and the risk of nonsyndromic cleft lip with or without cleft palate in a population from northern China. ( 28383424 )
2017

Variations for Cleft Lip

Expression for Cleft Lip

Search GEO for disease gene expression data for Cleft Lip.

GO Terms for Cleft Lip

Biological processes related to Cleft Lip according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.96 BMP4 IRF6 MSX1 TFAP2A TGFB3
2 wound healing GO:0042060 9.81 GRHL3 TGFA TGFB3
3 BMP signaling pathway GO:0030509 9.8 BMP4 MSX1 TGFB3
4 positive regulation of transcription, DNA-templated GO:0045893 9.8 BMP4 GRHL3 IRF6 PHF8 TFAP2A TGFB3
5 odontogenesis of dentin-containing tooth GO:0042475 9.71 BMP4 MSX1 TP63
6 pattern specification process GO:0007389 9.7 GRHL3 MID1 TP63
7 regulation of cell differentiation GO:0045595 9.67 BMP4 FGFR1 TFAP2A
8 camera-type eye morphogenesis GO:0048593 9.66 BMP4 NECTIN1
9 establishment of skin barrier GO:0061436 9.65 GRHL3 TP63
10 middle ear morphogenesis GO:0042474 9.65 FGFR1 MSX1
11 anatomical structure formation involved in morphogenesis GO:0048646 9.65 BMP4 TP63
12 positive regulation of bone mineralization GO:0030501 9.65 BMP4 TFAP2A TGFB3
13 odontogenesis GO:0042476 9.63 BMP4 MSX1 TGFB3
14 positive regulation of SMAD protein import into nucleus GO:0060391 9.62 BMP4 TGFB3
15 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.61 BMP4 MSX1
16 eyelid development in camera-type eye GO:0061029 9.61 GRHL3 TFAP2A
17 establishment of planar polarity GO:0001736 9.6 GRHL3 TP63
18 keratinocyte proliferation GO:0043616 9.59 IRF6 TP63
19 smooth muscle tissue development GO:0048745 9.58 BMP4 TP63
20 organ induction GO:0001759 9.58 BMP4 FGFR1
21 embryonic forelimb morphogenesis GO:0035115 9.58 MSX1 TFAP2A TP63
22 salivary gland morphogenesis GO:0007435 9.57 FGFR1 TGFB3
23 negative regulation of transcription by RNA polymerase II GO:0000122 9.56 BMP4 DLX4 FGFR1 MSX1 SUMO1 TFAP2A
24 embryonic hindlimb morphogenesis GO:0035116 9.54 BMP4 MSX1 TP63
25 BMP signaling pathway involved in heart development GO:0061312 9.51 BMP4 MSX1
26 embryonic limb morphogenesis GO:0030326 9.46 BMP4 FGFR1 MSX1 TP63
27 cloacal septation GO:0060197 9.43 BMP4 TP63
28 palate development GO:0060021 9.02 MSX1 SUMO1 TFAP2A TGFB3 VAX1
29 transcription, DNA-templated GO:0006351 10.3 FGFR1 GRHL3 IRF6 MSX1 PHF8 TBX10
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 BMP4 GRHL3 IRF6 MSX1 TFAP2A TGFB3
31 transcription by RNA polymerase II GO:0006366 10.06 GRHL3 IRF6 MSX1 TFAP2A TP63
32 regulation of transcription, DNA-templated GO:0006355 10.06 DLX4 FGFR1 GRHL3 IRF6 MSX1 PHF8
33 negative regulation of transcription, DNA-templated GO:0045892 10.04 BMP4 MSX1 SUMO1 TFAP2A TP63
34 negative regulation of apoptotic process GO:0043066 10.03 BMP4 MSX1 TFAP2A TGFA TP63

Molecular functions related to Cleft Lip according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.63 DLX4 IRF6 TBX10 TFAP2A TP63 VAX1
2 sequence-specific DNA binding GO:0043565 9.17 DLX4 GRHL3 IRF6 MSX1 TFAP2A TP63
3 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000982 8.96 MSX1 TFAP2A

Sources for Cleft Lip

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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