Aliases & Classifications for Cleft Lip

MalaCards integrated aliases for Cleft Lip:

Name: Cleft Lip 12 52 42 14
Cleft Lip, Unilateral, Complete 12
Complete Unilateral Cleft Lip 12
Labium Leporinum 12
Cheiloschisis 12
Hare Lip 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9296
ICD10 33 Q36 Q36.9
MeSH 42 D002971
NCIt 47 C87175

Summaries for Cleft Lip

MalaCards based summary : Cleft Lip, also known as cleft lip, unilateral, complete, is related to popliteal pterygium syndrome 1 and cleft lip/palate. An important gene associated with Cleft Lip is MSX1 (Msh Homeobox 1), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Hyaluronic acid and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and eye, and related phenotypes are craniofacial and growth/size/body region

Related Diseases for Cleft Lip

Diseases related to Cleft Lip via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
id Related Disease Score Top Affiliating Genes
1 popliteal pterygium syndrome 1 32.1 GRHL3 IRF6 TFAP2A
2 cleft lip/palate 12.5
3 cleft lip/palate-ectodermal dysplasia syndrome 12.4
4 cleft lip +/- cleft palate 12.3
5 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.2
6 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.2
7 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.2
8 isolated cleft lip 12.1
9 cleft lip and alveolus 12.1
10 polydactyly cleft lip palate psychomotor retardation 12.1
11 microbrachycephaly ptosis cleft lip 12.0
12 median cleft lip/mandibule 12.0
13 hay-wells syndrome 12.0
14 orofacial cleft 11 11.9
15 cleft lip/palate with abnormal thumbs and microcephaly 11.9
16 ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 1 11.9
17 coloboma, cleft lip/palate and mental retardation syndrome 11.9
18 van der woude syndrome 11.9
19 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 11.9
20 microcephaly, corpus callosum dysgenesis and cleft lip-palate 11.9
21 eec syndrome 11.9
22 amelia cleft lip palate hydrocephalus iris coloboma 11.8
23 anophthalmia cleft lip palate hypothalamic disorder 11.8
24 cleft lip and palate malrotation cardiopathy 11.8
25 cleft lip and/or palate with mucous cysts of lower 11.8
26 cleft lip palate dysmorphism kumar type 11.8
27 cleft lip palate mental retardation corneal opacity 11.8
28 cleft lip palate oligodontia syndactyly pili torti 11.8
29 cleft lip palate pituitary deficiency 11.8
30 cleft lip palate-tetraphocomelia 11.8
31 craniosynostosis cleft lip palate arthrogryposis 11.8
32 holoprosencephaly ectrodactyly cleft lip palate 11.8
33 lagophthalmia cleft lip palate 11.8
34 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 11.8
35 syndactyly ectodermal dysplasia cleft lip palate hand foot 11.8
36 tibial hemimelia cleft lip palate 11.8
37 cleft lip, congenital healed 11.8
38 cleft lip/palate-deafness-sacral lipoma syndrome 11.8
39 cleft lip-retinopathy syndrome 11.8
40 auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome 11.8
41 rapp-hodgkin syndrome 11.8
42 roberts syndrome 11.7
43 blepharocheilodontic syndrome 11.7
44 hartsfield syndrome 11.6
45 zlotogora syndrome 11.6
46 orofacial cleft 6 11.6
47 orofacial cleft 5 11.6
48 orofacial cleft 10 11.5
49 acrofrontofacionasal dysostosis 11.5
50 branchiooculofacial syndrome 11.5

Graphical network of the top 20 diseases related to Cleft Lip:



Diseases related to Cleft Lip

Symptoms & Phenotypes for Cleft Lip

MGI Mouse Phenotypes related to Cleft Lip:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.31 BMP4 FGFR1 GRHL3 IRF6 MSX1 NECTIN1
2 growth/size/body region MP:0005378 10.31 MID1 MSX1 MTHFR NECTIN1 SUMO1 TBX10
3 digestive/alimentary MP:0005381 10.26 BMP4 FGFR1 GRHL3 IRF6 MSX1 SUMO1
4 behavior/neurological MP:0005386 10.21 TBX10 TFAP2A TGFB3 TP63 BMP4 FGFR1
5 embryo MP:0005380 10.11 TGFB3 TP63 BMP4 FGFR1 GRHL3 IRF6
6 integument MP:0010771 10.11 BMP4 FGFR1 GRHL3 IRF6 MSX1 MTHFR
7 mortality/aging MP:0010768 10.1 BMP4 FGFR1 GRHL3 IRF6 MID1 MSX1
8 limbs/digits/tail MP:0005371 9.97 TFAP2A TGFB3 TP63 BMP4 FGFR1 GRHL3
9 hearing/vestibular/ear MP:0005377 9.88 BMP4 FGFR1 IRF6 MSX1 TBX10 TFAP2A
10 normal MP:0002873 9.81 BMP4 FGFR1 GRHL3 MID1 SUMO1 TBX10
11 skeleton MP:0005390 9.65 IRF6 MSX1 MTHFR TFAP2A TGFA TGFB3
12 vision/eye MP:0005391 9.4 BMP4 FGFR1 GRHL3 MSX1 MTHFR NECTIN1

Drugs & Therapeutics for Cleft Lip

Drugs for Cleft Lip (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
5 Adjuvants, Immunologic Phase 4
6 Protective Agents Phase 4
7 Viscosupplements Phase 4
8 Anesthetics Phase 4,Phase 2,Phase 3
9 Anesthetics, General Phase 4,Phase 2,Phase 3
10 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3
11 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
12 Anti-Bacterial Agents Phase 4
13 Antibiotics, Antitubercular Phase 4
14 Anti-Infective Agents Phase 4
15 Antitubercular Agents Phase 4
16 Anesthetics, Inhalation Phase 4
17 Hypnotics and Sedatives Phase 4
18 Platelet Aggregation Inhibitors Phase 4
19
Acetylcholine Approved Phase 3,Phase 1,Phase 2 51-84-3 187
20
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
21
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
22
Levobupivacaine Approved Phase 2, Phase 3 27262-47-1 92253
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
24
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
25 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
26 Botulinum Toxins Phase 3,Phase 1,Phase 2
27 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2
28 Cholinergic Agents Phase 3,Phase 1,Phase 2
29 Neuromuscular Agents Phase 3,Phase 1,Phase 2
30 Neurotransmitter Agents Phase 3,Phase 2,Phase 1
31 onabotulinumtoxinA Phase 3,Phase 1,Phase 2
32 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
33 Analgesics Phase 2, Phase 3
34 Anesthetics, Dissociative Phase 2, Phase 3
35 Anesthetics, Local Phase 2, Phase 3
36 Excitatory Amino Acid Antagonists Phase 2, Phase 3
37 Excitatory Amino Acids Phase 2, Phase 3
38 Hematinics Phase 3
39 Micronutrients Phase 3
40 Trace Elements Phase 3
41 Vitamin B Complex Phase 3
42 Vitamins Phase 3
43 Folate Nutraceutical Phase 3
44 Vitamin B9 Nutraceutical Phase 3
45
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
46
Morphine Approved, Investigational 57-27-2 5288826
47
Adenosine Approved, Investigational 58-61-7 60961
48 Daminozide 1596-84-5
49 Adjuvants, Anesthesia
50 Analgesics, Opioid

Interventional clinical trials:

(show top 50) (show all 63)

id Name Status NCT ID Phase Drugs
1 Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles Completed NCT01212809 Phase 4
2 The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair Recruiting NCT02688634 Phase 4 Amoxicillin
3 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
4 Botulinum Toxin to Improve Results in Cleft Lip Repair Unknown status NCT01429402 Phase 3 Botulinum Toxin Type A;Botulinum Type A;Normal Saline;Normal Saline
5 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
6 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811 Phase 2, Phase 3
7 Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery. Completed NCT02514980 Phase 2, Phase 3 Bupivacaine;Ketamine
8 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
9 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
10 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3 Levobupivacaine;Bupivacaine
11 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
12 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
13 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
14 Effect of Platelet Rich Plasma (PRP) on the Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair Not yet recruiting NCT02958306 Phase 2
15 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726
16 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998
17 Biochemical and Histological Comparison of Nasal and Auricular Cartilage in the Fetus and Newborn With Cleft Lip Carrier Unknown status NCT02505360
18 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
19 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623
20 FaceBase Biorepository Unknown status NCT01252264
21 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
22 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714
23 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
24 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598
25 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164
26 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
27 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
28 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
29 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509
30 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 MORPHINE PLUS FENTANYL;Fentanyl
31 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
32 Tympanometric Analysis in Cleft Palate Completed NCT01820689
33 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
34 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
35 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
36 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
37 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
38 Child's Adipose Cells: Capacity of Tissue Regeneration Completed NCT02779205
39 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
40 Sleep and Behavior in Children With Cleft Palate Completed NCT01046591
41 Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population Completed NCT00341068
42 Child and Infant Learning Project Completed NCT00077831
43 Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome. Completed NCT01178242
44 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
45 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Recruiting NCT03029195
46 Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants Recruiting NCT02845193
47 Evaluation of the Effect of Botulinum Toxin Type-A Injection Prior to Surgical Correction of Complete Unilateral Cleft Lip Repair by Modified Millard Cheiloplasty Recruiting NCT03047499 Botulinum toxin type A
48 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
49 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686
50 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Recruiting NCT02900014

Search NIH Clinical Center for Cleft Lip

Cochrane evidence based reviews: cleft lip

Genetic Tests for Cleft Lip

Anatomical Context for Cleft Lip

MalaCards organs/tissues related to Cleft Lip:

39
Bone, Heart, Eye, Skin, Salivary Gland, Breast, Thyroid

Publications for Cleft Lip

Articles related to Cleft Lip:

(show top 50) (show all 1166)
id Title Authors Year
1
"Camouflaging Cleft Lip Scar Using Follicular Unit Extraction Hair Transplantation Combined With Autologous Fat Grafting." ( 28938366 )
2017
2
International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome instrument for children and young adults with cleft lip and/or palate (CLEFT-Q). ( 28077415 )
2017
3
Cleft Lip and Palate: An Experience of a Developing Center in Egypt. ( 28922239 )
2017
4
Assessment of complete unilateral cleft lip and palate patients: Determination of factors effecting dental arch relationships. ( 28012538 )
2017
5
Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate-Part 2: Relationship between root resorption, horizontal tooth movement, and quantity of grafted autogenous bone. ( 28906140 )
2017
6
Novel findings of left ventricular non-compaction cardiomyopathy, microform cleft lip and poor vision in patient with SMC1A-associated Cornelia de Lange syndrome. ( 28102598 )
2017
7
Polymorphic variants in VAX1 and the risk of nonsyndromic cleft lip with or without cleft palate in a population from northern China. ( 28383424 )
2017
8
Cleft Lip and Palate Repair: Our Experience. ( 28906329 )
2017
9
Outcomes of an International Volunteer Surgical Project for Patients with Cleft Lip and/or Cleft Palate: A Mission in Developing Laos. ( 28949405 )
2017
10
Genitourinary malformations: an under-recognized feature of ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome. ( 28166087 )
2017
11
Three-dimensional printed haptic model from a prenatal surface-rendered oropalatal sonographic view: a new tool in the surgical planning of cleft lip/palate. ( 28673724 )
2017
12
3D analysis of effects of primary surgeries in cleft lip/palate children during the first two years of life. ( 28591242 )
2017
13
Association of single-nucleotide polymorphisms of CDH1 with nonsyndromic cleft lip with or without cleft palate in a northern Chinese Han population. ( 28151848 )
2017
14
The Americleft Project: A Modification of Asher-McDade Method for Rating Nasolabial Esthetics in Patients With Unilateral Cleft Lip and Palate Using Q-sort. ( 28906328 )
2017
15
Discussion: A Comparative Study of the Aesthetic Outcome of Two Techniques for Unilateral Complete Cleft Lip Repair. ( 28953727 )
2017
16
Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients After Primary Cheiloplasty Without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. ( 28085515 )
2017
17
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome. ( 28230601 )
2017
18
Imputation of Orofacial Clefting Data Identifies Novel Risk Loci and Sheds Light on the Genetic Background of Cleft Lip A+ Cleft Palate and Cleft Palate Only. ( 28087736 )
2017
19
Comparing Modified Huddart-Bodenham Scoring System and GOSLON Yardstick to Assess Dental Arch Relationships in Unilateral Cleft Lip and Palate Patients. ( 28092164 )
2017
20
Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate-Part 1: Relationship between root length and orthodontic tooth movement. ( 28906139 )
2017
21
Analysis of dermal fibroblasts isolated from neonatal and child cleft lip and adult skin: Developmental implications on reconstructive surgery. ( 28901389 )
2017
22
Examination of Nasolacrimal Duct Morphometry Using Cone Beam Computed Tomography in Patients With Unilateral Cleft Lip/Palate. ( 28891896 )
2017
23
Effects of pre-surgical nasoalveolar moulding on maxillary arch and nasal form in unilateral cleft lip and palate before lip surgery. ( 28921849 )
2017
24
Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. ( 28069795 )
2017
25
The association study of nonsyndromic cleft lip with or without cleft palate identified risk variants of the GLI3 gene in a Chinese population. ( 28947718 )
2017
26
The Serological Evidence of Cytomegalovirus Infection as a Potent Aetiological Factor for Cleft Lip/Palate, Mental Retardation and Deafness. ( 28764293 )
2017
27
The Smile Index Part 1: A Large-Scale Study of Phenotypic Norms for Pre- and Post-Operative Unilateral Cleft Lip. ( 28922326 )
2017
28
Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate. ( 28767310 )
2017
29
Subcutaneous C Shape Muscular Flap for Correcting the Depression of Alar Base in Affected Side in Patients With Unilateral Complete Cleft Lip/Palate During Primary Surgery. ( 28230602 )
2017
30
A Comparative Study of the Aesthetic Outcome of Two Techniques for Unilateral Complete Cleft Lip Repair. ( 28953726 )
2017
31
Evaluation of lip force in patients with unilateral and bilateral cleft lip. ( 28087210 )
2017
32
Nucleotide variants of the NAT2 and EGF61 genes in patients in Northern China with nonsyndromic cleft lip with or without cleft palate. ( 28906376 )
2017
33
The Effect of DynaCleftAr on Cleft Width in Unilateral Cleft Lip and Palate Patients. ( 28937909 )
2017
34
Skoog Primary Periosteoplasty versus Secondary Alveolar Bone Grafting in Unilateral Cleft Lip and Alveolus: Long-Term Effects on Alveolar Bone Formation and Maxillary Growth. ( 28027239 )
2017
35
Dynamic facial asymmetry in patients with repaired cleft lip using 4D imaging (video stereophotogrammetry). ( 28011182 )
2017
36
A Comparative Study of Oral Microbiota in Infants with Complete Cleft Lip and Palate or Cleft Soft Palate. ( 28393073 )
2017
37
FOXE1 Mutation Screening in a Case with Cleft Lip, Hypothyroidism, and Thyroid Carcinoma: A New Syndrome? ( 28928994 )
2017
38
Effect of Preoperative Nasal Retainer on Nasal Growth in Patients with Bilateral Incomplete Cleft Lip: A 3-Year Follow-Up Study. ( 28946721 )
2017
39
Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. ( 28054174 )
2017
40
Establishing Content Validity of the CLEFT-Q: A New Patient-reported Outcome Instrument for Cleft Lip/Palate. ( 28507866 )
2017
41
Facial profile esthetics in operated children with bilateral cleft lip and palate. ( 28902248 )
2017
42
BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate: A meta-analysis. ( 28767592 )
2017
43
Common variants in DLG1 locus are associated with non-syndromic cleft lip with or without cleft palate. ( 28926086 )
2017
44
Cleft sidedness and congenitally missing teeth in patients with cleft lip and palate patients. ( 27135068 )
2016
45
Replantation of a displaced incisor in a boy with a cleft lip and alveolus: a case report. ( 27633512 )
2016
46
Association Between the Transforming Growth Factor Beta 1 Gene Polymorphisms and Turkish Patients with Nonsyndromic Cleft Lip With/Without Cleft Palate. ( 26954016 )
2016
47
Chinese children with nonsyndromic cleft lip/palate: Factors associated with hearing disorder. ( 27497398 )
2016
48
Rescue of lip switch flap at risk of necrosis due to venous congestion for cleft lip deformity. ( 27583269 )
2016
49
Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data. ( 27630819 )
2016
50
Tomographic Pharyngeal Dimensions in Individuals With Unilateral Cleft Lip/Palate and Class III Malocclusion Are Reduced When Compared With Controls. ( 27148639 )
2016

Variations for Cleft Lip

Expression for Cleft Lip

Search GEO for disease gene expression data for Cleft Lip.

GO Terms for Cleft Lip

Biological processes related to Cleft Lip according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 9.95 GRHL3 MSX1 TFAP2A TP63
2 negative regulation of cell proliferation GO:0008285 9.93 BMP4 IRF6 MSX1 TFAP2A TGFB3
3 wound healing GO:0042060 9.8 GRHL3 TGFA TGFB3
4 positive regulation of transcription, DNA-templated GO:0045893 9.8 BMP4 GRHL3 IRF6 PHF8 TFAP2A TGFB3
5 BMP signaling pathway GO:0030509 9.79 BMP4 MSX1 TGFB3
6 odontogenesis of dentin-containing tooth GO:0042475 9.69 BMP4 MSX1 TP63
7 pattern specification process GO:0007389 9.67 GRHL3 MID1 TP63
8 establishment of skin barrier GO:0061436 9.65 GRHL3 TP63
9 middle ear morphogenesis GO:0042474 9.64 FGFR1 MSX1
10 anatomical structure formation involved in morphogenesis GO:0048646 9.64 BMP4 TP63
11 regulation of cell differentiation GO:0045595 9.63 BMP4 FGFR1 TFAP2A
12 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.61 BMP4 MSX1
13 positive regulation of bone mineralization GO:0030501 9.61 BMP4 TFAP2A TGFB3
14 eyelid development in camera-type eye GO:0061029 9.6 GRHL3 TFAP2A
15 smooth muscle tissue development GO:0048745 9.59 BMP4 TP63
16 establishment of planar polarity GO:0001736 9.58 GRHL3 TP63
17 positive regulation of SMAD protein import into nucleus GO:0060391 9.58 BMP4 TGFB3
18 odontogenesis GO:0042476 9.58 BMP4 MSX1 TGFB3
19 keratinocyte proliferation GO:0043616 9.57 IRF6 TP63
20 organ induction GO:0001759 9.56 BMP4 FGFR1
21 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.56 BMP4 DLX4 FGFR1 MSX1 SUMO1 TFAP2A
22 salivary gland morphogenesis GO:0007435 9.55 FGFR1 TGFB3
23 BMP signaling pathway involved in heart development GO:0061312 9.48 BMP4 MSX1
24 embryonic limb morphogenesis GO:0030326 9.46 BMP4 FGFR1 MSX1 TP63
25 cloacal septation GO:0060197 9.37 BMP4 TP63
26 palate development GO:0060021 9.02 MSX1 SUMO1 TFAP2A TGFB3 VAX1
27 transcription, DNA-templated GO:0006351 10.29 FGFR1 GRHL3 IRF6 MSX1 PHF8 TBX10
28 regulation of transcription, DNA-templated GO:0006355 10.06 DLX4 FGFR1 GRHL3 IRF6 MSX1 PHF8
29 negative regulation of transcription, DNA-templated GO:0045892 10.02 BMP4 MSX1 SUMO1 TFAP2A TP63
30 negative regulation of apoptotic process GO:0043066 10.02 BMP4 MSX1 TFAP2A TGFA TP63
31 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10 BMP4 GRHL3 MSX1 TFAP2A TGFB3 TP63

Molecular functions related to Cleft Lip according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 9.63 DLX4 IRF6 TBX10 TFAP2A TP63 VAX1
2 sequence-specific DNA binding GO:0043565 9.1 DLX4 GRHL3 MSX1 TFAP2A TP63 VAX1
3 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000982 8.96 MSX1 TFAP2A

Sources for Cleft Lip

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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