MCID: CLF025
MIFTS: 20

Cleft Lip +/- Cleft Palate malady

Genetic diseases (common), Oral diseases categories

Aliases & Classifications for Cleft Lip +/- Cleft Palate

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Aliases & Descriptions for Cleft Lip +/- Cleft Palate:

Name: Cleft Lip +/- Cleft Palate 22
 
Orofacial Cleft, Nonsyndromic 22


Classifications:



External Ids:

ICD1027 Q35-Q37

Summaries for Cleft Lip +/- Cleft Palate

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MalaCards based summary: Cleft Lip +/- Cleft Palate, also known as orofacial cleft, nonsyndromic, is related to cleft lip and holoprosencephaly caudal dysgenesis. An important gene associated with Cleft Lip +/- Cleft Palate is TP63 (Tumor Protein P63).

Related Diseases for Cleft Lip +/- Cleft Palate

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Graphical network of the top 20 diseases related to Cleft Lip +/- Cleft Palate:



Diseases related to cleft lip +/- cleft palate

Symptoms for Cleft Lip +/- Cleft Palate

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Drugs & Therapeutics for Cleft Lip +/- Cleft Palate

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Drugs for Cleft Lip +/- Cleft Palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Folic Acidapproved, nutraceuticalPhase 3285159-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
2Vitamin B ComplexPhase 32775
3Folinic AcidNutraceuticalPhase 32498
4Vitamin B9NutraceuticalPhase 32851
5FolateNutraceuticalPhase 32851
6Botulinum Toxins, Type APhase 1, Phase 2561
7Botulinum ToxinsPhase 1, Phase 2590

Interventional clinical trials:

(show all 33)
idNameStatusNCT IDPhase
1The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency RepairNot yet recruitingNCT02688634Phase 4
2Oral Cleft Prevention Trial in BrazilCompletedNCT00098319Phase 3
3Assessing the Results of Lip Surgery in Patients With Cleft Lip and PalateCompletedNCT00070811Phase 2, Phase 3
4Oral Cleft Prevention ProgramActive, not recruitingNCT00397917Phase 3
5Cleft Palate Surgery and Speech DevelopmentCompletedNCT00004639Phase 2
6Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better?CompletedNCT00930124Phase 2
7Improvement of the Appearance of Cleft Lip Scars Using BotoxRecruitingNCT02247193Phase 1, Phase 2
8Articulation and Phonology in Children With Unilateral Cleft Lip and PalateCompletedNCT00829101
9Systematic Pediatric Care for Oral Clefts - South AmericaCompletedNCT00097149
10Tympanometric Analysis in Cleft PalateCompletedNCT01820689
11Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical OutcomesCompletedNCT01380171
12Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the AbnormalityCompletedNCT00993993
13A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/PalateCompletedNCT00156442
14Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment)CompletedNCT00340977
15Sleep and Behavior in Children With Cleft PalateCompletedNCT01046591
16Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish PopulationCompletedNCT00341068
17Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of HolopresencephalyCompletedNCT00005016
18Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial DifferencesCompletedNCT00340964
19Genetic Analysis of Fraser Syndrome and Fryns SyndromeCompletedNCT00032877
20Child and Infant Learning ProjectCompletedNCT00077831
21Follow Ups of Parents With Infants With Cleft Lip and PalateRecruitingNCT02415361
22FaceBase BiorepositoryRecruitingNCT01252264
233D Imaging of Hard and Soft Tissue in Orthognathic SurgeryRecruitingNCT00285714
24One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I OsteotomyRecruitingNCT01871623
25The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome)RecruitingNCT01601171
26Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate PatientsActive, not recruitingNCT02329509
27Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate PatientsActive, not recruitingNCT01932164
28Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic TreatmentActive, not recruitingNCT02454998
29Osteogenesis and Dental Eruption Through Electrical StimuliActive, not recruitingNCT00975208
30Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip PatientEnrolling by invitationNCT01883726
31IAN Injury After BSSO in Oral CleftsNot yet recruitingNCT01875965
32Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized TrialNot yet recruitingNCT01883687
33TWIST Human Gene and Cleft Lips and PalatesTerminatedNCT00213889

Search NIH Clinical Center for Cleft Lip +/- Cleft Palate

Genetic Tests for Cleft Lip +/- Cleft Palate

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Genetic tests related to Cleft Lip +/- Cleft Palate:

id Genetic test Affiliating Genes
1 Cleft Lip +/- Cleft Palate22 TP63

Anatomical Context for Cleft Lip +/- Cleft Palate

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Animal Models for Cleft Lip +/- Cleft Palate or affiliated genes

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Publications for Cleft Lip +/- Cleft Palate

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Articles related to Cleft Lip +/- Cleft Palate:

(show all 30)
idTitleAuthorsYear
1
Center of cleft lip-cleft palate and craniofacial deformities, Khon Kaen University in association with "Tawanchai Project" and Faculty of Medicine, Khon Kaen University. (25816529)
2014
2
Center of cleft lip-cleft palate and craniofacial deformities, Khon Kaen University in association with "Tawanchai Project" and Faculty of Medicine, Khon Kaen University. (25816530)
2014
3
Occipital meningoencephalocele with Cleft Lip, Cleft Palate and Limb Abnormalities- A Case Report. (25653933)
2014
4
ABM clinical protocol #18: guidelines for breastfeeding infants with cleft lip, cleft palate, or cleft lip and palate, revised 2013. (23886478)
2013
5
Center of Cleft Lip-cleft Palate and Craniofacial Deformities, Khon Kaen University in association with "Tawanchai Project" and Faculty Of Medicine, Khon Kaen University. (24386735)
2013
6
Cleft lip, cleft palate, hereditary diffuse gastric cancer and germline mutations in CDH1. (23124477)
2013
7
Parents' satisfaction with repair of paediatric cleft lip/cleft palate in Honduras. (23930730)
2013
8
Early correction of septum JJ deformity in unilateral cleft lip-cleft palate. (22929267)
2012
9
Center of Cleft Lip-Cleft Palate and Craniofacial Deformities, Khon Kaen University in association with "Tawanchai Project" and Faculty of Medicine, Khon Kaen University. Foreword. (23961610)
2012
10
2012 American Board of Pediatric Dentistry College of Diplomates annual meeting: the role of pediatric dentists in the presurgical treatment of infants with cleft lip/cleft palate utilizing nasoalveolar molding. (23387096)
2012
11
Long-term effect of primary cleft rhinoplasty on secondary cleft rhinoplasty in patients with unilateral cleft lip-cleft palate. (22373979)
2012
12
Is presurgical nasoalveolar molding therapy more effective in unilateral or bilateral cleft lip-cleft palate patients? (21088643)
2011
13
Cleft lip, cleft palate, and velopharyngeal insufficiency. (21921748)
2011
14
Current national incidence, trends, and health care resource utilization of cleft lip-cleft palate. (21364426)
2011
15
Changing patterns in demography of cleft lip-cleft palate deformities in a developing country: the Smile Train effect--what lies ahead? (21200226)
2011
16
Center of Cleft lip-Cleft palate and Craniofacial Deformities, Khon Kaen University in association with "Tawanchai project" and faculty of medicine Khon Kaen University. Foreword. (22423407)
2011
17
From birth to maturity: a group of patients who have completed their protocol management. Part III. Bilateral cleft lip-cleft palate. (21788838)
2011
18
Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate. (21328261)
2011
19
Changing patterns in demography of cleft lip-cleft palate deformities in a developing country: the Smile Train effect--what lies ahead? (21866012)
2011
20
A 12-year anthropometric evaluation of the nose in bilateral cleft lip-cleft palate patients following nasoalveolar molding and cutting bilateral cleft lip and nose reconstruction. (21460673)
2011
21
Comparison of periodontal status among patients with cleft lip, cleft palate, and cleft lip along with a cleft in palate and alveolus. (21760670)
2010
22
Cleft lip-cleft palate closure: the unknown contributions of Harvey Cushing. (20885253)
2010
23
Non-syndromic cleft lip/cleft palate and C677T methylene-tetrahydrofolate reductase variant in Mexican children]. (20550866)
2009
24
A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate. (17594395)
2007
25
Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate. (16199551)
2005
26
An international surgical exchange program for children with cleft lip/cleft palate in Manaus, Brazil: patient and family expectations of outcome. (14704585)
2004
27
Association of holoprosencephaly, ectrodactyly, cleft lip/cleft palate and hypertelorism: a possible third case. (9689997)
1998
28
Informative morphogenetic and phenogenetic variants in children with cleft lip/cleft palate. (8723125)
1996
29
Infants with cleft lip/cleft palate. (3054837)
1988
30
Nursing care of the cleft-lip/cleft-palate child. (4489308)
1973

Variations for Cleft Lip +/- Cleft Palate

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Expression for genes affiliated with Cleft Lip +/- Cleft Palate

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Search GEO for disease gene expression data for Cleft Lip +/- Cleft Palate.

Pathways for genes affiliated with Cleft Lip +/- Cleft Palate

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GO Terms for genes affiliated with Cleft Lip +/- Cleft Palate

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Cellular components related to Cleft Lip +/- Cleft Palate according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:00430059.3MTHFR, TP63

Biological processes related to Cleft Lip +/- Cleft Palate according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-templatedGO:00458939.0PHF8, TP63

Molecular functions related to Cleft Lip +/- Cleft Palate according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:00036829.0PHF8, TP63

Sources for Cleft Lip +/- Cleft Palate

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet