MCID: CLF025
MIFTS: 23

Cleft Lip +/- Cleft Palate malady

Categories: Oral diseases, Genetic diseases

Aliases & Classifications for Cleft Lip +/- Cleft Palate

Aliases & Descriptions for Cleft Lip +/- Cleft Palate:

Name: Cleft Lip +/- Cleft Palate 24
Orofacial Cleft, Nonsyndromic 24

Classifications:



External Ids:

ICD10 33 Q35-Q37

Summaries for Cleft Lip +/- Cleft Palate

MalaCards based summary : Cleft Lip +/- Cleft Palate, also known as orofacial cleft, nonsyndromic, is related to eec syndrome and mcpherson clemens syndrome. An important gene associated with Cleft Lip +/- Cleft Palate is TP63 (Tumor Protein P63). The drugs Sevoflurane and Amoxicillin have been mentioned in the context of this disorder.

Wikipedia : 71 Cleft lip and cleft palate, also known as orofacial cleft, is a group of conditions that includes cleft... more...

Related Diseases for Cleft Lip +/- Cleft Palate

Graphical network of the top 20 diseases related to Cleft Lip +/- Cleft Palate:



Diseases related to Cleft Lip +/- Cleft Palate

Symptoms & Phenotypes for Cleft Lip +/- Cleft Palate

Drugs & Therapeutics for Cleft Lip +/- Cleft Palate

Drugs for Cleft Lip +/- Cleft Palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4 Anesthetics Phase 4,Phase 2,Phase 3
5 Anesthetics, General Phase 4
6 Anesthetics, Intravenous Phase 4
7 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
8 Anesthetics, Inhalation Phase 4
9 Hypnotics and Sedatives Phase 4
10 Anti-Bacterial Agents Phase 4
11 Platelet Aggregation Inhibitors Phase 4
12 Anti-Infective Agents Phase 4
13 Antibiotics, Antitubercular Phase 4
14 Antitubercular Agents Phase 4
15
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
16
Levobupivacaine Approved Phase 2, Phase 3 27262-47-1 92253
17
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
19 Hematinics Phase 3
20 Trace Elements Phase 3
21 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
22 Anesthetics, Local Phase 2, Phase 3
23 Vitamin B Complex Phase 3
24 Vitamins Phase 3
25 Micronutrients Phase 3
26 Folate Nutraceutical Phase 3
27 Vitamin B9 Nutraceutical Phase 3
28
Acetylcholine Approved Phase 1, Phase 2 51-84-3 187
29 Cholinergic Agents Phase 1, Phase 2
30 Neuromuscular Agents Phase 1, Phase 2
31 Neurotransmitter Agents Phase 1, Phase 2
32 abobotulinumtoxinA Phase 1, Phase 2
33 incobotulinumtoxinA Phase 1, Phase 2
34 onabotulinumtoxinA Phase 1, Phase 2
35 Botulinum Toxins Phase 1, Phase 2
36 Botulinum Toxins, Type A Phase 1, Phase 2
37
Morphine Approved, Investigational 57-27-2 5288826
38
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
39
Menthol Approved 2216-51-5 16666
40 Daminozide 1596-84-5
41 Analgesics
42 Adjuvants, Anesthesia
43 Narcotics
44 Analgesics, Opioid

Interventional clinical trials:

(show all 50)
id Name Status NCT ID Phase
1 The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair Recruiting NCT02688634 Phase 4
2 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4
3 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3
4 Oral Cleft Prevention Program Completed NCT00397917 Phase 3
5 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811 Phase 2, Phase 3
6 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3
7 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
8 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
9 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2
10 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Unknown status NCT01932164
11 FaceBase Biorepository Unknown status NCT01252264
12 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998
13 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
14 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623
15 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714
16 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726
17 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
18 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
19 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509
20 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
21 Tympanometric Analysis in Cleft Palate Completed NCT01820689
22 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
23 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
24 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
25 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540
26 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
27 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
28 Sleep and Behavior in Children With Cleft Palate Completed NCT01046591
29 Child's Adipose Cells: Capacity of Tissue Regeneration Completed NCT02779205
30 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
31 Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population Completed NCT00341068
32 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
33 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
34 Child and Infant Learning Project Completed NCT00077831
35 Follow Ups of Parents With Infants With Cleft Lip and Palate Recruiting NCT02415361
36 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
37 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
38 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Recruiting NCT03029195
39 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Recruiting NCT02900014
40 Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants Recruiting NCT02845193
41 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686
42 The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome) Recruiting NCT01601171
43 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
44 Stentless Endoscopic Transnasal Transseptal Choanoplasty Recruiting NCT03167463
45 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207
46 Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study Recruiting NCT03165331
47 Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome Recruiting NCT01144741
48 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Not yet recruiting NCT03011489
49 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Not yet recruiting NCT02881606
50 TWIST Human Gene and Cleft Lips and Palates Terminated NCT00213889

Search NIH Clinical Center for Cleft Lip +/- Cleft Palate

Genetic Tests for Cleft Lip +/- Cleft Palate

Genetic tests related to Cleft Lip +/- Cleft Palate:

id Genetic test Affiliating Genes
1 Cleft Lip +/- Cleft Palate 24 TP63

Anatomical Context for Cleft Lip +/- Cleft Palate

Publications for Cleft Lip +/- Cleft Palate

Articles related to Cleft Lip +/- Cleft Palate:

(show all 31)
id Title Authors Year
1
Center of cleft lip-cleft palate and craniofacial deformities, Khon Kaen University in association with "Tawanchai Project" and Faculty of Medicine, Khon Kaen University. ( 25816529 )
2014
2
Occipital meningoencephalocele with Cleft Lip, Cleft Palate and Limb Abnormalities- A Case Report. ( 25653933 )
2014
3
Center of cleft lip-cleft palate and craniofacial deformities, Khon Kaen University in association with "Tawanchai Project" and Faculty of Medicine, Khon Kaen University. ( 25816530 )
2014
4
Parents' satisfaction with repair of paediatric cleft lip/cleft palate in Honduras. ( 23930730 )
2013
5
Center of Cleft Lip-cleft Palate and Craniofacial Deformities, Khon Kaen University in association with "Tawanchai Project" and Faculty Of Medicine, Khon Kaen University. ( 24386735 )
2013
6
Cleft lip, cleft palate, hereditary diffuse gastric cancer and germline mutations in CDH1. ( 23124477 )
2013
7
ABM clinical protocol #18: guidelines for breastfeeding infants with cleft lip, cleft palate, or cleft lip and palate, revised 2013. ( 23886478 )
2013
8
2012 American Board of Pediatric Dentistry College of Diplomates annual meeting: the role of pediatric dentists in the presurgical treatment of infants with cleft lip/cleft palate utilizing nasoalveolar molding. ( 23387096 )
2012
9
Center of Cleft Lip-Cleft Palate and Craniofacial Deformities, Khon Kaen University in association with "Tawanchai Project" and Faculty of Medicine, Khon Kaen University. Foreword. ( 23961610 )
2012
10
Long-term effect of primary cleft rhinoplasty on secondary cleft rhinoplasty in patients with unilateral cleft lip-cleft palate. ( 22373979 )
2012
11
Early correction of septum JJ deformity in unilateral cleft lip-cleft palate. ( 22929267 )
2012
12
Current national incidence, trends, and health care resource utilization of cleft lip-cleft palate. ( 21364426 )
2011
13
Is presurgical nasoalveolar molding therapy more effective in unilateral or bilateral cleft lip-cleft palate patients? ( 21088643 )
2011
14
Cleft lip, cleft palate, and velopharyngeal insufficiency. ( 21921748 )
2011
15
A 12-year anthropometric evaluation of the nose in bilateral cleft lip-cleft palate patients following nasoalveolar molding and cutting bilateral cleft lip and nose reconstruction. ( 21460673 )
2011
16
Changing patterns in demography of cleft lip-cleft palate deformities in a developing country: the Smile Train effect--what lies ahead? ( 21200226 )
2011
17
Center of Cleft lip-Cleft palate and Craniofacial Deformities, Khon Kaen University in association with "Tawanchai project" and faculty of medicine Khon Kaen University. Foreword. ( 22423407 )
2011
18
From birth to maturity: a group of patients who have completed their protocol management. Part III. Bilateral cleft lip-cleft palate. ( 21788838 )
2011
19
Changing patterns in demography of cleft lip-cleft palate deformities in a developing country: the Smile Train effect--what lies ahead? ( 21866012 )
2011
20
Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate. ( 21328261 )
2011
21
Cleft lip-cleft palate closure: the unknown contributions of Harvey Cushing. ( 20885253 )
2010
22
Comparison of periodontal status among patients with cleft lip, cleft palate, and cleft lip along with a cleft in palate and alveolus. ( 21760670 )
2010
23
[Non-syndromic cleft lip/cleft palate and C677T methylene-tetrahydrofolate reductase variant in Mexican children]. ( 20550866 )
2009
24
A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate. ( 17594395 )
2007
25
Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate. ( 17661819 )
2007
26
Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate. ( 16199551 )
2005
27
An international surgical exchange program for children with cleft lip/cleft palate in Manaus, Brazil: patient and family expectations of outcome. ( 14704585 )
2004
28
Association of holoprosencephaly, ectrodactyly, cleft lip/cleft palate and hypertelorism: a possible third case. ( 9689997 )
1998
29
Informative morphogenetic and phenogenetic variants in children with cleft lip/cleft palate. ( 8723125 )
1996
30
Infants with cleft lip/cleft palate. ( 3054837 )
1988
31
Nursing care of the cleft-lip/cleft-palate child. ( 4489308 )
1973

Variations for Cleft Lip +/- Cleft Palate

Expression for Cleft Lip +/- Cleft Palate

Search GEO for disease gene expression data for Cleft Lip +/- Cleft Palate.

Pathways for Cleft Lip +/- Cleft Palate

GO Terms for Cleft Lip +/- Cleft Palate

Molecular functions related to Cleft Lip +/- Cleft Palate according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.62 PHF8 TP63

Sources for Cleft Lip +/- Cleft Palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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