MCID: CLF025
MIFTS: 20

Cleft Lip +/- Cleft Palate malady

Categories: Genetic diseases (common), Oral diseases

Aliases & Classifications for Cleft Lip +/- Cleft Palate

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Aliases & Descriptions for Cleft Lip +/- Cleft Palate:

Name: Cleft Lip +/- Cleft Palate 22
 
Orofacial Cleft, Nonsyndromic 22

Classifications:



External Ids:

ICD1027 Q35-Q37

Summaries for Cleft Lip +/- Cleft Palate

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Wikipedia:68 Cleft lip and cleft palate, also known as orofacial cleft, is a group of conditions that includes cleft... more...

MalaCards based summary: Cleft Lip +/- Cleft Palate, also known as orofacial cleft, nonsyndromic, is related to eec syndrome and mcpherson clemens syndrome. An important gene associated with Cleft Lip +/- Cleft Palate is TP63 (Tumor Protein P63). Affiliated tissues include bone, breast and liver.

Related Diseases for Cleft Lip +/- Cleft Palate

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Graphical network of the top 20 diseases related to Cleft Lip +/- Cleft Palate:



Diseases related to cleft lip +/- cleft palate

Symptoms for Cleft Lip +/- Cleft Palate

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Drugs & Therapeutics for Cleft Lip +/- Cleft Palate

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Drugs for Cleft Lip +/- Cleft Palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AmoxicillinapprovedPhase 439126787-78-033613, 2171
Synonyms:
(-)-6-(2-Amino-2-(P-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-(3.2.0)heptane-2-carboxylic acid
(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
26787-78-0
33911-69-2
34642-77-8 (mono-hydrochloride salt)
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-, D- (8CI)
6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid
6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin
6-(P-Hydroxy-alpha-aminophenylacetamido)penicillanic acid
6-(a-Amino-4-hydroxyphenylacetamido)penicillanic acid
6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid
6-(p-hydroxy-╬▒-aminophenylacetamido)penicillanic acid
6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 9CI
61336-70-7 (TRIHYDRATE)
6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carbonyl
6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
71447-36-4
81030-75-3
AC-12263
AC1L1PY2
AMC
AMOXICILLIN CRYSTALLINE
AMOXICILLIN PEDIATRIC
AMPC
AUGMENTIN '125'
AUGMENTIN '200'
AUGMENTIN '250'
AUGMENTIN '400'
AUGMENTIN '500'
AUGMENTIN '875'
AUGMENTIN ES-600
AX
Actimoxi
Almodan
Ambap26787-78-0
Amix
Amoclen
Amolin
Amopen
Amopenixin
Amoram
Amox
Amox 250 Cap 250mg
Amox 500 Cap 500mg
Amox S 125 Sus 125mg/5ml
Amox S 250 Sus 250mg/5ml
Amoxi
Amoxi-Mast
Amoxi-mast
Amoxibiotic
Amoxicaps
Amoxicilina
Amoxicilina [INN-Spanish]
Amoxicillin
Amoxicillin (INN)
Amoxicillin (TN)
Amoxicillin (anhydrous)
Amoxicillin (inn)
Amoxicillin Extended-release
Amoxicillin Trihydrate
Amoxicillin and clavulanate potassium
Amoxicillin anhydrous
Amoxicillin pediatric
Amoxicillin sodium
Amoxicillin trihydrate
Amoxicillin(usan)
Amoxicilline
Amoxicilline [INN-French]
Amoxicilline [INN]
Amoxicilline [inn]
Amoxicillinum
Amoxicillinum [INN-Latin]
Amoxid
Amoxiden
Amoxil
Amoxivet
Amoxycillin
Amoxycillin Trihydrate
Amoxycillin trihydrate
Amoxycillin, BAN
Amoxymed
Amrit
Anemolin
Apo-Amoxi
Apo-Amoxi Cap 250mg
Apo-Amoxi Cap 500mg
Apo-Amoxi Pwr for Susp 125mg/5ml
Apo-Amoxi Pwr for Susp 250mg/5ml
Apo-amoxi
Apo-amoxi sugar free
Aspenil
Augmentinxr
BL-P 1410
BLP 1410
BPBio1_000499
BRD-K55044200-001-03-9
BRL 2333
 
BRL-2333
BSPBio_000453
Biomox
Bristamox
C06827
CHEBI:2676
CHEBI:53712
CHEMBL1082
CID33613
CPD000058707
Cemoxin
Clamoxyl
Clamoxyl (SKB)
D-(-)-alpha-Amino-p-hydroxybenzyl penicillin
D-(-)-alpha-Amino-p-hydroxybenzylpenicillin
D-(alpha-Amino-p-hydroxybenzyl)penicillin
D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid
D-Amoxicillin
D07452
DB01060
Delacillin
DisperMox
Dispermox
EINECS 248-003-8
Efpenix
Flemoxin
Galenamox
Gen-Amoxicillin 250mg
Gen-Amoxicillin 500mg
HMS1569G15
HSDB 3204
Hiconcil
Histocillin
Hydroxyampicillin
Ibiamox
Imacillin
LS-149721
Lamoxy
Larotid
MLS000028632
MLS002222248
Metafarma capsules
Metifarma capsules
MolPort-003-981-182
MolPort-005-933-687
Moxacin
Moxal
Moxatag
NCGC00179554-01
NSC 277174
NSC277174
Novamoxin
Novamoxin Cap 250mg
Novamoxin Cap 500mg
Novamoxin Sus 125mg/5ml
Novamoxin Sus 250mg/5ml
Nu-Amoxi Cap 250mg
Nu-Amoxi Cap 500mg
Nu-Amoxi Sus 125/5ml
Nu-Amoxi Sus 250mg/5ml
Ospamox
P-Hydroxyampicillin
PHL-amoxicillin
PMS-amoxicillin
Pamoxicillin
Piramox
Polymox
Prestwick0_000357
Prestwick1_000357
Prestwick2_000357
Prestwick3_000357
Prestwick_713
Prevpac
Pro Amox Pwr for Oral Susp 125mg/5ml
Pro Amox-250 Cap 250mg
Pro Amox-500 Cap 500mg
Pro-Amox-250 Orl Sus 250mg/5ml
R-Hydroxyampicillin
Rimoxallin
Ro 10-8756
Robamox
SAM002264592
SMR000058707
SPBio_002374
Sauracillin
Sawamox PM
Sumox
Tolodina
Trimox
Unicillin
Utimox
Vetramox
Wymox
Zimox
alpha-Amino-p-hydroxybenzylpenicillin
alpha-amino-P-Hydroxybenzylpenicillin
amoxicillanyl
amoxicillin
p-Hydroxyampicillin
╬▒-amino-p-hydroxybenzylpenicillin
2Anti-Infective AgentsPhase 417220
3Antitubercular AgentsPhase 41061
4Antibiotics, AntitubercularPhase 45971
5Anti-Bacterial AgentsPhase 49140
6
Folic Acidapproved, nutraceuticalPhase 3292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
7Trace ElementsPhase 33900
8VitaminsPhase 33857
9MicronutrientsPhase 33901
10Vitamin B ComplexPhase 32847
11HematinicsPhase 31121
12Vitamin B9NutraceuticalPhase 32924
13FolateNutraceuticalPhase 32924
14Folinic AcidNutraceuticalPhase 32604
15
AcetylcholineexperimentalPhase 1, Phase 268951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
16Neurotransmitter AgentsPhase 1, Phase 214795
17OnabotulinumtoxinAPhase 1, Phase 2588
18Peripheral Nervous System AgentsPhase 1, Phase 218510
19Neuromuscular AgentsPhase 1, Phase 2922
20Botulinum ToxinsPhase 1, Phase 2616
21AbobotulinumtoxinAPhase 1, Phase 2588
22Botulinum Toxins, Type APhase 1, Phase 2588
23Cholinergic AgentsPhase 1, Phase 23243
24IncobotulinumtoxinAPhase 1, Phase 2599

Interventional clinical trials:

(show all 35)
idNameStatusNCT IDPhase
1The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency RepairNot yet recruitingNCT02688634Phase 4
2Oral Cleft Prevention Trial in BrazilCompletedNCT00098319Phase 3
3Assessing the Results of Lip Surgery in Patients With Cleft Lip and PalateCompletedNCT00070811Phase 2, Phase 3
4Oral Cleft Prevention ProgramActive, not recruitingNCT00397917Phase 3
5Cleft Palate Surgery and Speech DevelopmentCompletedNCT00004639Phase 2
6Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better?CompletedNCT00930124Phase 2
7Improvement of the Appearance of Cleft Lip Scars Using BotoxRecruitingNCT02247193Phase 1, Phase 2
8Articulation and Phonology in Children With Unilateral Cleft Lip and PalateCompletedNCT00829101
9Systematic Pediatric Care for Oral Clefts - South AmericaCompletedNCT00097149
10Tympanometric Analysis in Cleft PalateCompletedNCT01820689
11Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical OutcomesCompletedNCT01380171
12Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the AbnormalityCompletedNCT00993993
13A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/PalateCompletedNCT00156442
14Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment)CompletedNCT00340977
15Sleep and Behavior in Children With Cleft PalateCompletedNCT01046591
16Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish PopulationCompletedNCT00341068
17Child's Adipose Cells: Capacity of Tissue RegenerationCompletedNCT02779205
18Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of HolopresencephalyCompletedNCT00005016
19Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial DifferencesCompletedNCT00340964
20Genetic Analysis of Fraser Syndrome and Fryns SyndromeCompletedNCT00032877
21Child and Infant Learning ProjectCompletedNCT00077831
22Follow Ups of Parents With Infants With Cleft Lip and PalateRecruitingNCT02415361
23FaceBase BiorepositoryRecruitingNCT01252264
243D Imaging of Hard and Soft Tissue in Orthognathic SurgeryRecruitingNCT00285714
25One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I OsteotomyRecruitingNCT01871623
26The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome)RecruitingNCT01601171
27Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate PatientsActive, not recruitingNCT02329509
28Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate PatientsActive, not recruitingNCT01932164
29Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic TreatmentActive, not recruitingNCT02454998
30Osteogenesis and Dental Eruption Through Electrical StimuliActive, not recruitingNCT00975208
31Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip PatientEnrolling by invitationNCT01883726
32Prospective Data-collection System for the Comprehensive Appraisal of Cleft CareNot yet recruitingNCT02702869
33IAN Injury After BSSO in Oral CleftsNot yet recruitingNCT01875965
34Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized TrialNot yet recruitingNCT01883687
35TWIST Human Gene and Cleft Lips and PalatesTerminatedNCT00213889

Search NIH Clinical Center for Cleft Lip +/- Cleft Palate

Genetic Tests for Cleft Lip +/- Cleft Palate

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Genetic tests related to Cleft Lip +/- Cleft Palate:

id Genetic test Affiliating Genes
1 Cleft Lip +/- Cleft Palate22 TP63

Anatomical Context for Cleft Lip +/- Cleft Palate

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MalaCards organs/tissues related to Cleft Lip +/- Cleft Palate:

33
Bone, Breast, Liver, Placenta

Animal Models for Cleft Lip +/- Cleft Palate or affiliated genes

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Publications for Cleft Lip +/- Cleft Palate

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Articles related to Cleft Lip +/- Cleft Palate:

(show all 31)
idTitleAuthorsYear
1
Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response. (26438868)
2015
2
Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex. (24692662)
2014
3
PPARI^/I' activation of CD300a controls intestinal immunity. (24958459)
2014
4
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. (25038754)
2014
5
Evaluation of two new automated chemiluminescent assays (HemosILAr AcuStar HIT-IgG and HemosILAr AcuStar HIT-Ab) for the detection of heparin-induced antibodies in the diagnosis of heparin-induced thrombocytopenia. (22405611)
2012
6
Constrictive pericarditis with extensive calcification. (21308337)
2011
7
Pathogenesis and progression of proteinuria. (21659757)
2011
8
Alternative splicing modulates inactivation of type 1 voltage-gated sodium channels by toggling an amino acid in the first S3-S4 linker. (21890636)
2011
9
Well-differentiated neuroendocrine carcinoma mimicking an echinococcus cyst of the liver in CT-MRI findings with hepatocyte specific contrast material. (22187713)
2011
10
Quality assessment in open surgical repair of thoracic aortic disease. (19834855)
2009
11
Acute effects of exposure to vapours of standard and dearomatized white spirits in humans. 2. Irritation and inflammation. (19086013)
2009
12
Association between MGMT promoter hypermethylation and p53 mutation in glioblastoma. (19544111)
2009
13
Effects of salinomycin on cell-mediated immunity of broiler chickens against hydropericardium syndrome and Newcastle disease viruses. (19096061)
2009
14
Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (18785206)
2009
15
Clarithromycin. (18486039)
2008
16
Inhibition of interleukin-6 expression by the V protein of parainfluenza virus 5. (17692882)
2007
17
Desferrioxamine (DFX) has genotoxic effects on cultured human lymphocytes and induces the p53-mediated damage response. (17147976)
2007
18
Paraovarian hemangioma with immunoglobulin deposits in a patient with monoclonal gammopathy of uncertain significance and osteolytic lesions. (15455229)
2005
19
Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations. (15863145)
2005
20
Placental expression of human histocompatibility antigen-G mRNA in idiopathic fetal growth restriction and its relationship with pathological changes of placenta]. (15924672)
2005
21
Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus. (14764811)
2004
22
Dementia in the neuronal ceroid-lipofuscinoses. (11403161)
2001
23
The use of frailty models in genetic studies: application to the relationship between end-stage renal failure and mutation type in Alport syndrome. European Community Alport Syndrome Concerted Action Group (ECASCA). (11051113)
2000
24
Synthetic peptide as retinoid vector and antiproliferative agent]. (9759373)
1998
25
Retroperitoneal fibrosis: unusual localization. (9755992)
1998
26
Terminal differentiation of facial epidermis of the aged: immunohistochemical studies. (8305750)
1994
27
A case of Kearns-Sayre syndrome with metaphyseal dysplasia. (8516029)
1993
28
MELAS syndrome with mitochondrial tRNA(Leu)(UUR) mutation: correlation of clinical state, nerve conduction, and muscle 31P magnetic resonance spectroscopy during treatment with nicotinamide and riboflavin. (1436526)
1992
29
Birdshot chorioretinopathy: an etiological problem. (7343040)
1981
30
A case of Lennox-Gastaut syndrome successfully treated by removal of a parietotemporal astrocytoma. (115678)
1979
31
Lid rhinosporidiosis - simulating a tumor. (1247945)
1976

Variations for Cleft Lip +/- Cleft Palate

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Expression for genes affiliated with Cleft Lip +/- Cleft Palate

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Search GEO for disease gene expression data for Cleft Lip +/- Cleft Palate.

Pathways for genes affiliated with Cleft Lip +/- Cleft Palate

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GO Terms for genes affiliated with Cleft Lip +/- Cleft Palate

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Sources for Cleft Lip +/- Cleft Palate

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet