FLP
MCID: CLF004
MIFTS: 46

Cleft Lip/palate (FLP) malady

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip/palate

Summaries for Cleft Lip/palate

MedlinePlus : 41 cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. they happen early during pregnancy. a baby can have a cleft lip, a cleft palate, or both. a cleft lip happens if the tissue that makes up the lip does not join completely before birth. this causes an opening in the upper lip. the opening can be a small slit or a large opening that goes through the lip into the nose. it can be on one or both sides of the lip or, rarely, in the middle of the lip. children with a cleft lip also can have a cleft palate. the roof of the mouth is called the "palate." with a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. babies may have both the front and back parts of the palate open, or they may have only one part open. children with a cleft lip or a cleft palate often have problems with feeding and talking. they also might have ear infections, hearing loss, and problems with their teeth. often, surgery can close the lip and palate. cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. many children have other complications. they may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. with treatment, most children with clefts do well and lead a healthy life. centers for disease control and prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to cleft lip/palate-ectodermal dysplasia syndrome and ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Angiogenesis (CST) and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Sevoflurane and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and heart, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 cleft lip/palate-ectodermal dysplasia syndrome 12.6
2 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.5
3 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.4
4 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.2
5 coloboma, cleft lip/palate and mental retardation syndrome 12.2
6 ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 1 12.2
7 cleft lip/palate with abnormal thumbs and microcephaly 12.2
8 polydactyly cleft lip palate psychomotor retardation 12.2
9 hay-wells syndrome 12.1
10 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.1
11 microcephaly, corpus callosum dysgenesis and cleft lip-palate 12.1
12 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.1
13 craniosynostosis cleft lip palate arthrogryposis 12.1
14 tibial hemimelia cleft lip palate 12.1
15 holoprosencephaly ectrodactyly cleft lip palate 12.1
16 amelia cleft lip palate hydrocephalus iris coloboma 12.1
17 lagophthalmia cleft lip palate 12.1
18 cleft lip/palate-deafness-sacral lipoma syndrome 12.1
19 anophthalmia cleft lip palate hypothalamic disorder 12.1
20 cleft lip palate dysmorphism kumar type 12.1
21 cleft lip palate mental retardation corneal opacity 12.1
22 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 12.1
23 cleft lip palate oligodontia syndactyly pili torti 12.1
24 cleft lip palate pituitary deficiency 12.1
25 cleft lip palate-tetraphocomelia 12.1
26 eec syndrome 12.1
27 cleft lip and palate malrotation cardiopathy 12.0
28 hartsfield syndrome 11.9
29 rapp-hodgkin syndrome 11.9
30 vici syndrome 11.8
31 acrofrontofacionasal dysostosis 11.8
32 popliteal pterygium syndrome 1 11.7
33 blepharocheilodontic syndrome 11.6
34 pilotto syndrome 11.6
35 zlotogora syndrome 11.4
36 orofaciodigital syndrome vi 11.2
37 roberts syndrome 11.2
38 medeira-dennis-donnai syndrome 11.2
39 kapur-toriello syndrome 11.2
40 short-rib thoracic dysplasia 6 with or without polydactyly 11.1
41 short-rib thoracic dysplasia 9 with or without polydactyly 11.1
42 short-rib thoracic dysplasia 8 with or without polydactyly 11.1
43 opitz gbbb syndrome, type i 11.1
44 short-rib thoracic dysplasia 7 with or without polydactyly 11.1
45 short-rib thoracic dysplasia 10 with or without polydactyly 11.1
46 short-rib thoracic dysplasia 11 with or without polydactyly 11.1
47 short-rib thoracic dysplasia 4 with or without polydactyly 11.1
48 short-rib thoracic dysplasia 3 with or without polydactyly 11.1
49 short-rib thoracic dysplasia 2 with or without polydactyly 11.1
50 short-rib thoracic dysplasia 14 with polydactyly 11.1

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate

Symptoms & Phenotypes for Cleft Lip/palate

MGI Mouse Phenotypes related to Cleft Lip/palate:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.28 TGFA TP63 MTHFR MTRR YAP1 NECTIN1
2 homeostasis/metabolism MP:0005376 10.18 TP63 MTHFR MTRR YAP1 NECTIN1 TBX22
3 digestive/alimentary MP:0005381 10.17 TGFA TP63 YAP1 TBX22 LHX8 FGFR1
4 craniofacial MP:0005382 10.16 TGFA TP63 NECTIN1 TBX22 LHX8 FGFR1
5 integument MP:0010771 10.1 TGFA TP63 MTHFR YAP1 NECTIN1 FGFR1
6 mortality/aging MP:0010768 9.97 TBX22 TP63 MTHFR YAP1 NECTIN1 CDH1
7 limbs/digits/tail MP:0005371 9.73 MSX1 TP63 MTHFR IRF6 FGFR1 BMP4
8 no phenotypic analysis MP:0003012 9.5 TP63 MTHFR CDH1 LHX8 FGFR1 MSX1
9 skeleton MP:0005390 9.28 TBX22 TGFA TP63 MTHFR MMP3 FGFR1

Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4 Anesthetics Phase 4,Phase 2,Phase 3
5 Anesthetics, General Phase 4
6 Anesthetics, Intravenous Phase 4
7 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
8 Anesthetics, Inhalation Phase 4
9 Hypnotics and Sedatives Phase 4
10 Anti-Bacterial Agents Phase 4
11 Platelet Aggregation Inhibitors Phase 4
12 Anti-Infective Agents Phase 4
13 Antibiotics, Antitubercular Phase 4
14 Antitubercular Agents Phase 4
15
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
16
Levobupivacaine Approved Phase 2, Phase 3 27262-47-1 92253
17
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
19 Hematinics Phase 3
20 Trace Elements Phase 3
21 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
22 Anesthetics, Local Phase 2, Phase 3
23 Vitamin B Complex Phase 3
24 Vitamins Phase 3
25 Micronutrients Phase 3
26 Folate Nutraceutical Phase 3
27 Vitamin B9 Nutraceutical Phase 3
28
Acetylcholine Approved Phase 1, Phase 2 51-84-3 187
29 Cholinergic Agents Phase 1, Phase 2
30 Neuromuscular Agents Phase 1, Phase 2
31 Neurotransmitter Agents Phase 1, Phase 2
32 abobotulinumtoxinA Phase 1, Phase 2
33 incobotulinumtoxinA Phase 1, Phase 2
34 onabotulinumtoxinA Phase 1, Phase 2
35 Botulinum Toxins Phase 1, Phase 2
36 Botulinum Toxins, Type A Phase 1, Phase 2
37
Morphine Approved, Investigational 57-27-2 5288826
38
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
39
Menthol Approved 2216-51-5 16666
40 Daminozide 1596-84-5
41 Analgesics
42 Adjuvants, Anesthesia
43 Narcotics
44 Analgesics, Opioid

Interventional clinical trials:

(show all 50)
id Name Status NCT ID Phase
1 The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair Recruiting NCT02688634 Phase 4
2 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4
3 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811 Phase 2, Phase 3
4 Oral Cleft Prevention Program Completed NCT00397917 Phase 3
5 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3
6 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3
7 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
8 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
9 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2
10 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Unknown status NCT01932164
11 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623
12 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998
13 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
14 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
15 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
16 FaceBase Biorepository Unknown status NCT01252264
17 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726
18 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714
19 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
20 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
21 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509
22 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540
23 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
24 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
25 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
26 Tympanometric Analysis in Cleft Palate Completed NCT01820689
27 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
28 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
29 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
30 Child and Infant Learning Project Completed NCT00077831
31 Sleep and Behavior in Children With Cleft Palate Completed NCT01046591
32 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
33 Child's Adipose Cells: Capacity of Tissue Regeneration Completed NCT02779205
34 Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population Completed NCT00341068
35 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
36 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Recruiting NCT03029195
37 Follow Ups of Parents With Infants With Cleft Lip and Palate Recruiting NCT02415361
38 Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants Recruiting NCT02845193
39 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686
40 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
41 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Recruiting NCT02900014
42 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
43 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207
44 Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study Recruiting NCT03165331
45 Stentless Endoscopic Transnasal Transseptal Choanoplasty Recruiting NCT03167463
46 The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome) Recruiting NCT01601171
47 Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome Recruiting NCT01144741
48 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Not yet recruiting NCT03011489
49 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Not yet recruiting NCT02881606
50 TWIST Human Gene and Cleft Lips and Palates Terminated NCT00213889

Search NIH Clinical Center for Cleft Lip/palate

Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

id Genetic test Affiliating Genes
1 Cleft Lip/palate 29

Anatomical Context for Cleft Lip/palate

MalaCards organs/tissues related to Cleft Lip/palate:

39
Bone, Skin, Heart

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

(show top 50) (show all 128)
id Title Authors Year
1
Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients After Primary Cheiloplasty Without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. ( 28085515 )
2017
2
Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model. ( 27927890 )
2016
3
Comparison of dental arch dimensions in models of preschool children with cleft lip/palate repaired by means of surgery alone versus controls. ( 27749647 )
2016
4
Computer-Assisted Orthognathic Surgery for Patients with Cleft Lip/Palate: From Traditional Planning to Three-Dimensional Surgical Simulation. ( 27002726 )
2016
5
MSX1 gene polymorphisms in Mexican patients with non-syndromic cleft lip/palate. ( 27729116 )
2016
6
Suboptimal Performance in Cleft Lip/Palate Children- Who is Responsible? ( 27891420 )
2016
7
Gene Interactions Provide Evidence for Signaling Pathways Involved in Cleft Lip/Palate in Humans. ( 27154735 )
2016
8
Modified Activation Technique for Nasal Stent of Nasoalveolar Molding Appliance for Columellar Lengthening in Bilateral Cleft Lip/Palate. ( 27002917 )
2016
9
Time trend of incidence rates of cleft lip/palate in Taiwan from 1994 to 2013. ( 27372171 )
2016
10
Management of feeding Problem in a Patient with Cleft Lip/Palate. ( 27365936 )
2016
11
Recurrence of split hand/foot malformation, cleft lip/palate, and severe urogenital abnormalities due to germline mosaicism for TP63 mutation. ( 27351625 )
2016
12
Novel variant in the TP63 gene associated to ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome. ( 27485918 )
2016
13
ICD-10-based expanded code set for use in cleft lip/palate research and surveillance. ( 27891780 )
2016
14
Prenatal diagnosis of cleft lip/palate: The surface rendered oro-palatalA (SROP) view of the fetal lips and palate, a tool to improve information-sharing within the orofacial team and with the parents. ( 27211349 )
2016
15
Cleft characteristics and treatment outcomes in hemifacial microsomia compared to non-syndromic cleft lip/palate. ( 26775633 )
2016
16
Fetal Cleft Lip/Palate Surgery: End of a Dream? ( 27115723 )
2016
17
Factors contributing to hearing impairment in patients with cleft lip/palate in Malaysia: A prospective study of 346 ears. ( 27497393 )
2016
18
Chinese children with nonsyndromic cleft lip/palate: Factors associated with hearing disorder. ( 27497398 )
2016
19
Five-year speech and language outcomes in children with cleft lip-palate. ( 27614545 )
2016
20
Tomographic Pharyngeal Dimensions in Individuals With Unilateral Cleft Lip/Palate and Class III Malocclusion Are Reduced When Compared With Controls. ( 27148639 )
2016
21
Policy on Management of Patients with Cleft Lip/Palate and Other Craniofacial Anomalies. ( 27931481 )
2016
22
Clinician's Primer to ICD-10-CM Coding for Cleft Lip/Palate Care. ( 26523325 )
2015
23
Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate. ( 26199944 )
2015
24
A novel c.1037C > G (p.Ala346Gly) mutation in TP63 as cause of the ectrodactyly-ectodermal dysplasia and cleft lip/palate (EEC) syndrome. ( 25983622 )
2015
25
Novel homozygous mutation, c.400C>T (p.Arg134*), in the PVRL1 gene underlies cleft lip/palate-ectodermal dysplasia syndrome in an Asian patient. ( 25913853 )
2015
26
Cleft lip/palate, short stature, and developmental delay in a boy with a 5.6-mb interstitial deletion involving 10p15.3p14. ( 25852446 )
2015
27
ALOBAR HOLOPROSENCEPHALY, CLEFT LIP/PALATE, URORECTAL SEPTUM MALFORMATION SEQUENCE AND CONGENITAL PERINEAL HERNIA IN A FETUS. ( 26625663 )
2015
28
IRF6 Is a Marker of Severity in Nonsyndromic Cleft Lip/Palate. ( 25896061 )
2015
29
Evaluation of Delayed Puberty in Adolescents With Cleft Lip/Palate. ( 26506041 )
2015
30
Parent-Reported Family Functioning Among Children With Cleft Lip/Palate. ( 25405543 )
2014
31
5,10-Methylenetetrahydrofolate reductase single nucleotide polymorphisms and gene-environment interaction analysis in non-syndromic cleft lip/palate. ( 24460828 )
2014
32
A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk. ( 24528994 )
2014
33
Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome: a case with a novel p63 mutation associated with abnormal keratohyalin granules. ( 24898013 )
2014
34
Functional Significance of MMP3 and TIMP2 Polymorphisms in Cleft Lip/Palate. ( 24799419 )
2014
35
Accelerated Wound Closure In Vitro by Fibroblasts from a Subgroup of Cleft Lip/Palate Patients: Role of Transforming Growth Factor-I+. ( 25360592 )
2014
36
Enhancing accessibility of patients with cleft lip/palate to healthcare services via a cleft birth registration system. ( 25816535 )
2014
37
Further evidence suggesting a role for variation in ARHGAP29 variants in nonsyndromic cleft lip/palate. ( 25163644 )
2014
38
Changes in Grafted Autogenous Bone During Edgewise Treatment in Patients With Unilateral Cleft Lip/Palate or Alveolus. ( 24047436 )
2013
39
Nursing care system development for patients with cleft lip-palate and craniofacial deformities in operating room Srinagarind Hospital. ( 24386741 )
2013
40
Registries of cleft lip/palate cases between 2004 and 2010 in Denizli, Turkey. ( 23479145 )
2013
41
Cleft lip/palate associated with 17p13.3 duplication involving a single candidate gene (YWHAE). ( 23901910 )
2013
42
A pilot study of mental health and quality-of-life of caregivers of children with cleft lip/palate in India. ( 23825852 )
2013
43
Preoperative lip measurement in patients with complete unilateral cleft lip/palate and its comparison with norms. ( 23276499 )
2013
44
Hydrocephalus, agenesis of the corpus callosum, and cleft lip/palate represent frequent associations in fetuses with Peters' plus syndrome and B3GALTL mutations. Fetal PPS phenotypes, expanded by Dandy Walker cyst and encephalocele. ( 23161355 )
2013
45
Parents' satisfaction with repair of paediatric cleft lip/palate in Honduras. ( 23930723 )
2013
46
Effects of lip revision surgery on long-term orosensory function in patients with cleft lip/palate. ( 22906391 )
2013
47
Nasoalveolar molding with active columellar lengthening in severe bilateral cleft lip/palate: a clinical report. ( 22946934 )
2013
48
Association of MSX1 799a88G>T variant with nonsyndromic cleft lip/palate in South Indian adolescent patients. ( 21972896 )
2012
49
Interstitial 9q34.11-q34.13 deletion in a patient with severe intellectual disability, hydrocephalus, and cleft lip/palate. ( 22639460 )
2012
50
A novel delivery system of probiotic drop and its effect on dental caries risk factors in cleft lip/palate children. ( 21309653 )
2012

Variations for Cleft Lip/palate

Expression for Cleft Lip/palate

Search GEO for disease gene expression data for Cleft Lip/palate.

Pathways for Cleft Lip/palate

Pathways related to Cleft Lip/palate according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.44 FGFR1 MMP3 TGFA
2 11.38 BMP4 IRF6 MSX1 TP63
3 11.29 CDH1 FGFR1 NECTIN1
4 10.93 BMP4 CDH1 FGFR1 MSX1
5 10.06 IRF6 TP63

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 8.96 CDH1 NECTIN1
2 catenin complex GO:0016342 8.62 CDH1 NECTIN1

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.97 BMP4 FOXE1 MSX1 TBX22 TP63
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.8 BMP4 DLX4 FGFR1 FOXE1 MSX1 TBX22
3 positive regulation of transcription, DNA-templated GO:0045893 9.7 BMP4 CDH1 FOXE1 IRF6 PHF8 TP63
4 keratinocyte differentiation GO:0030216 9.69 IRF6 TP63 YAP1
5 camera-type eye morphogenesis GO:0048593 9.61 BMP4 NECTIN1
6 middle ear morphogenesis GO:0042474 9.6 FGFR1 MSX1
7 folic acid metabolic process GO:0046655 9.59 MTHFR MTRR
8 anatomical structure formation involved in morphogenesis GO:0048646 9.58 BMP4 TP63
9 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.56 BMP4 MSX1
10 keratinocyte proliferation GO:0043616 9.55 IRF6 TP63
11 organ induction GO:0001759 9.54 BMP4 FGFR1
12 smooth muscle tissue development GO:0048745 9.52 BMP4 TP63
13 pituitary gland development GO:0021983 9.5 BMP4 CDH1 MSX1
14 paraxial mesoderm development GO:0048339 9.49 FGFR1 YAP1
15 bud elongation involved in lung branching GO:0060449 9.46 BMP4 YAP1
16 BMP signaling pathway involved in heart development GO:0061312 9.43 BMP4 MSX1
17 methionine metabolic process GO:0006555 9.4 MTHFR MTRR
18 cloacal septation GO:0060197 9.37 BMP4 TP63
19 odontogenesis of dentin-containing tooth GO:0042475 9.26 BMP4 LHX8 MSX1 TP63
20 embryonic limb morphogenesis GO:0030326 8.92 BMP4 FGFR1 MSX1 TP63
21 transcription, DNA-templated GO:0006351 10.23 FGFR1 FOXE1 IRF6 LHX8 MSX1 PHF8
22 regulation of transcription, DNA-templated GO:0006355 10.18 DLX4 FGFR1 FOXE1 IRF6 LHX8 MSX1

Molecular functions related to Cleft Lip/palate according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.02 DLX4 FOXE1 LHX8 MSX1 TP63

Sources for Cleft Lip/palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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