MCID: CLF004
MIFTS: 45

Cleft Lip/palate

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip/palate

Summaries for Cleft Lip/palate

MedlinePlus : 41 cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. they happen early during pregnancy. a baby can have a cleft lip, a cleft palate, or both. a cleft lip happens if the tissue that makes up the lip does not join completely before birth. this causes an opening in the upper lip. the opening can be a small slit or a large opening that goes through the lip into the nose. it can be on one or both sides of the lip or, rarely, in the middle of the lip. children with a cleft lip also can have a cleft palate. the roof of the mouth is called the "palate." with a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. babies may have both the front and back parts of the palate open, or they may have only one part open. children with a cleft lip or a cleft palate often have problems with feeding and talking. they also might have ear infections, hearing loss, and problems with their teeth. often, surgery can close the lip and palate. cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. many children have other complications. they may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. with treatment, most children with clefts do well and lead a healthy life. centers for disease control and prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to cleft lip/palate-ectodermal dysplasia syndrome and ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Adherens junction. The drugs Amoxicillin and Propofol have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and heart, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
id Related Disease Score Top Affiliating Genes
1 cleft lip/palate-ectodermal dysplasia syndrome 12.6
2 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.5
3 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.4
4 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.4
5 polydactyly cleft lip palate psychomotor retardation 12.2
6 cleft lip/palate with abnormal thumbs and microcephaly 12.2
7 ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 1 12.2
8 coloboma, cleft lip/palate and mental retardation syndrome 12.2
9 hay-wells syndrome 12.2
10 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.1
11 microcephaly, corpus callosum dysgenesis and cleft lip-palate 12.1
12 amelia cleft lip palate hydrocephalus iris coloboma 12.1
13 anophthalmia cleft lip palate hypothalamic disorder 12.1
14 cleft lip palate dysmorphism kumar type 12.1
15 cleft lip palate mental retardation corneal opacity 12.1
16 cleft lip palate oligodontia syndactyly pili torti 12.1
17 cleft lip palate pituitary deficiency 12.1
18 cleft lip palate-tetraphocomelia 12.1
19 craniosynostosis cleft lip palate arthrogryposis 12.1
20 holoprosencephaly ectrodactyly cleft lip palate 12.1
21 lagophthalmia cleft lip palate 12.1
22 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 12.1
23 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.1
24 tibial hemimelia cleft lip palate 12.1
25 cleft lip/palate-deafness-sacral lipoma syndrome 12.1
26 eec syndrome 12.1
27 cleft lip and palate malrotation cardiopathy 12.0
28 rapp-hodgkin syndrome 11.9
29 hartsfield syndrome 11.9
30 acrofrontofacionasal dysostosis 11.8
31 blepharocheilodontic syndrome 11.8
32 popliteal pterygium syndrome 1 11.7
33 cleft palate, cardiac defects, and mental retardation 11.6
34 vici syndrome 11.4
35 zlotogora syndrome 11.4
36 orofaciodigital syndrome vi 11.2
37 roberts syndrome 11.2
38 kapur-toriello syndrome 11.2
39 medeira-dennis-donnai syndrome 11.2
40 short-rib thoracic dysplasia 15 with polydactyly 11.1
41 short-rib thoracic dysplasia 7 with or without polydactyly 11.1
42 short-rib thoracic dysplasia 10 with or without polydactyly 11.1
43 short-rib thoracic dysplasia 4 with or without polydactyly 11.1
44 short-rib thoracic dysplasia 2 with or without polydactyly 11.1
45 short-rib thoracic dysplasia 17 with or without polydactyly 11.1
46 short-rib thoracic dysplasia 5 with or without polydactyly 11.1
47 short-rib thoracic dysplasia 6 with or without polydactyly 11.1
48 short-rib thoracic dysplasia 8 with or without polydactyly 11.1
49 short-rib thoracic dysplasia 11 with or without polydactyly 11.1
50 short-rib thoracic dysplasia 3 with or without polydactyly 11.1

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate

Symptoms & Phenotypes for Cleft Lip/palate

MGI Mouse Phenotypes related to Cleft Lip/palate:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.21 CEP120 KIAA0586 FGFR1 MID1 BMP4 IFT172
2 cardiovascular system MP:0005385 10.18 CDH1 CEP120 KIAA0586 FGFR1 BMP4 IFT172
3 craniofacial MP:0005382 10.16 KIAA0586 FGFR1 BMP4 IFT172 IRF6 NEK1
4 embryo MP:0005380 10.14 CEP120 KIAA0586 FGFR1 MID1 BMP4 IFT172
5 digestive/alimentary MP:0005381 10.09 FGFR1 BMP4 IFT172 CDH1 IRF6 TGFA
6 integument MP:0010771 10.02 CDH1 IRF6 FGFR1 BMP4 NEK1 TGFA
7 mortality/aging MP:0010768 9.97 CDH1 IRF6 CEP120 KIAA0586 MID1 FGFR1
8 limbs/digits/tail MP:0005371 9.8 IRF6 KIAA0586 FGFR1 BMP4 IFT172 TP63
9 muscle MP:0005369 9.5 FGFR1 BMP4 YAP1 TGFA MID1 TP63
10 skeleton MP:0005390 9.32 IRF6 KIAA0586 FGFR1 BMP4 IFT172 NEK1

Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
4 Anesthetics Phase 4
5 Anesthetics, General Phase 4
6 Anesthetics, Intravenous Phase 4
7 Central Nervous System Depressants Phase 4
8 Anti-Bacterial Agents Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Anti-Infective Agents Phase 4
11 Antitubercular Agents Phase 4
12 Anesthetics, Inhalation Phase 4
13 Hypnotics and Sedatives Phase 4
14 Platelet Aggregation Inhibitors Phase 4
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
16
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
17 Hematinics Phase 3
18 Micronutrients Phase 3
19 Trace Elements Phase 3
20 Vitamin B Complex Phase 3
21 Vitamins Phase 3
22 Folate Nutraceutical Phase 3
23 Vitamin B9 Nutraceutical Phase 3
24
Acetylcholine Approved Phase 1, Phase 2 51-84-3 187
25 Peripheral Nervous System Agents Phase 1, Phase 2
26 abobotulinumtoxinA Phase 1, Phase 2
27 Botulinum Toxins Phase 1, Phase 2
28 Botulinum Toxins, Type A Phase 1, Phase 2
29 Cholinergic Agents Phase 1, Phase 2
30 Neuromuscular Agents Phase 1, Phase 2
31 Neurotransmitter Agents Phase 1, Phase 2
32 onabotulinumtoxinA Phase 1, Phase 2
33
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
34
Morphine Approved, Investigational 57-27-2 5288826
35 Daminozide 1596-84-5
36 Adjuvants, Anesthesia
37 Analgesics
38 Analgesics, Opioid
39 Narcotics

Interventional clinical trials:

(show all 50)

id Name Status NCT ID Phase Drugs
1 The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair Recruiting NCT02688634 Phase 4 Amoxicillin
2 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
3 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811 Phase 2, Phase 3
4 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
5 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
6 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
7 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
8 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
9 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
10 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623
11 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998
12 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
13 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
14 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
15 FaceBase Biorepository Unknown status NCT01252264
16 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726
17 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714
18 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
19 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164
20 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
21 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
22 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509
23 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 MORPHINE PLUS FENTANYL;Fentanyl
24 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
25 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
26 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
27 Tympanometric Analysis in Cleft Palate Completed NCT01820689
28 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
29 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
30 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
31 Child and Infant Learning Project Completed NCT00077831
32 Sleep and Behavior in Children With Cleft Palate Completed NCT01046591
33 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
34 Child's Adipose Cells: Capacity of Tissue Regeneration Completed NCT02779205
35 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
36 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Recruiting NCT03029195
37 Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants Recruiting NCT02845193
38 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686
39 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
40 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Recruiting NCT02900014
41 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
42 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207
43 Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study Recruiting NCT03165331
44 Stentless Endoscopic Transnasal Transseptal Choanoplasty Recruiting NCT03167463
45 Follow Ups of Parents With Infants With Cleft Lip and Palate Active, not recruiting NCT02415361
46 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Not yet recruiting NCT03011489
47 Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate Not yet recruiting NCT03219021
48 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Not yet recruiting NCT02881606
49 the Relationship Between Cleft Lip and / or Palate (Different Types) and ABO Blood Groups. Not yet recruiting NCT03217890
50 TWIST Human Gene and Cleft Lips and Palates Terminated NCT00213889

Search NIH Clinical Center for Cleft Lip/palate

Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

id Genetic test Affiliating Genes
1 Cleft Lip/palate 29

Anatomical Context for Cleft Lip/palate

MalaCards organs/tissues related to Cleft Lip/palate:

39
Bone, Skin, Heart

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

(show top 50) (show all 137)
id Title Authors Year
1
Genitourinary malformations: an under-recognized feature of ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome. ( 28166087 )
2017
2
Three-dimensional printed haptic model from a prenatal surface-rendered oropalatal sonographic view: a new tool in the surgical planning of cleft lip/palate. ( 28673724 )
2017
3
3D analysis of effects of primary surgeries in cleft lip/palate children during the first two years of life. ( 28591242 )
2017
4
Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients After Primary Cheiloplasty Without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. ( 28085515 )
2017
5
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome. ( 28230601 )
2017
6
Examination of Nasolacrimal Duct Morphometry Using Cone Beam Computed Tomography in Patients With Unilateral Cleft Lip/Palate. ( 28891896 )
2017
7
The Serological Evidence of Cytomegalovirus Infection as a Potent Aetiological Factor for Cleft Lip/Palate, Mental Retardation and Deafness. ( 28764293 )
2017
8
Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate. ( 28767310 )
2017
9
Subcutaneous C Shape Muscular Flap for Correcting the Depression of Alar Base in Affected Side in Patients With Unilateral Complete Cleft Lip/Palate During Primary Surgery. ( 28230602 )
2017
10
Establishing Content Validity of the CLEFT-Q: A New Patient-reported Outcome Instrument for Cleft Lip/Palate. ( 28507866 )
2017
11
Chinese children with nonsyndromic cleft lip/palate: Factors associated with hearing disorder. ( 27497398 )
2016
12
Tomographic Pharyngeal Dimensions in Individuals With Unilateral Cleft Lip/Palate and Class III Malocclusion Are Reduced When Compared With Controls. ( 27148639 )
2016
13
Comparison of dental arch dimensions in models of preschool children with cleft lip/palate repaired by means of surgery alone versus controls. ( 27749647 )
2016
14
Fetal Cleft Lip/Palate Surgery: End of a Dream? ( 27115723 )
2016
15
Cleft characteristics and treatment outcomes in hemifacial microsomia compared to non-syndromic cleft lip/palate. ( 26775633 )
2016
16
Computer-Assisted Orthognathic Surgery for Patients with Cleft Lip/Palate: From Traditional Planning to Three-Dimensional Surgical Simulation. ( 27002726 )
2016
17
Suboptimal Performance in Cleft Lip/Palate Children- Who is Responsible? ( 27891420 )
2016
18
Management of feeding Problem in a Patient with Cleft Lip/Palate. ( 27365936 )
2016
19
Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model. ( 27927890 )
2016
20
ICD-10-based expanded code set for use in cleft lip/palate research and surveillance. ( 27891780 )
2016
21
MSX1 gene polymorphisms in Mexican patients with non-syndromic cleft lip/palate. ( 27729116 )
2016
22
Prenatal diagnosis of cleft lip/palate: The surface rendered oro-palatalA (SROP) view of the fetal lips and palate, a tool to improve information-sharing within the orofacial team and with the parents. ( 27211349 )
2016
23
Factors contributing to hearing impairment in patients with cleft lip/palate in Malaysia: A prospective study of 346 ears. ( 27497393 )
2016
24
Time trend of incidence rates of cleft lip/palate in Taiwan from 1994 to 2013. ( 27372171 )
2016
25
Modified Activation Technique for Nasal Stent of Nasoalveolar Molding Appliance for Columellar Lengthening in Bilateral Cleft Lip/Palate. ( 27002917 )
2016
26
Policy on Management of Patients with Cleft Lip/Palate and Other Craniofacial Anomalies. ( 27931481 )
2016
27
Novel variant in the TP63 gene associated to ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome. ( 27485918 )
2016
28
Gene Interactions Provide Evidence for Signaling Pathways Involved in Cleft Lip/Palate in Humans. ( 27154735 )
2016
29
Five-year speech and language outcomes in children with cleft lip-palate. ( 27614545 )
2016
30
Recurrence of split hand/foot malformation, cleft lip/palate, and severe urogenital abnormalities due to germline mosaicism for TP63 mutation. ( 27351625 )
2016
31
Novel homozygous mutation, c.400C>T (p.Arg134*), in the PVRL1 gene underlies cleft lip/palate-ectodermal dysplasia syndrome in an Asian patient. ( 25913853 )
2015
32
Clinician's Primer to ICD-10-CM Coding for Cleft Lip/Palate Care. ( 26523325 )
2015
33
Evaluation of Delayed Puberty in Adolescents With Cleft Lip/Palate. ( 26506041 )
2015
34
IRF6 Is a Marker of Severity in Nonsyndromic Cleft Lip/Palate. ( 25896061 )
2015
35
ALOBAR HOLOPROSENCEPHALY, CLEFT LIP/PALATE, URORECTAL SEPTUM MALFORMATION SEQUENCE AND CONGENITAL PERINEAL HERNIA IN A FETUS. ( 26625663 )
2015
36
A novel c.1037C > G (p.Ala346Gly) mutation in TP63 as cause of the ectrodactyly-ectodermal dysplasia and cleft lip/palate (EEC) syndrome. ( 25983622 )
2015
37
Cleft lip/palate, short stature, and developmental delay in a boy with a 5.6-mb interstitial deletion involving 10p15.3p14. ( 25852446 )
2015
38
Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate. ( 26199944 )
2015
39
Accelerated Wound Closure In Vitro by Fibroblasts from a Subgroup of Cleft Lip/Palate Patients: Role of Transforming Growth Factor-I+. ( 25360592 )
2014
40
5,10-Methylenetetrahydrofolate reductase single nucleotide polymorphisms and gene-environment interaction analysis in non-syndromic cleft lip/palate. ( 24460828 )
2014
41
Functional Significance of MMP3 and TIMP2 Polymorphisms in Cleft Lip/Palate. ( 24799419 )
2014
42
Further evidence suggesting a role for variation in ARHGAP29 variants in nonsyndromic cleft lip/palate. ( 25163644 )
2014
43
Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome: a case with a novel p63 mutation associated with abnormal keratohyalin granules. ( 24898013 )
2014
44
Enhancing accessibility of patients with cleft lip/palate to healthcare services via a cleft birth registration system. ( 25816535 )
2014
45
A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk. ( 24528994 )
2014
46
Parent-Reported Family Functioning Among Children With Cleft Lip/Palate. ( 25405543 )
2014
47
Changes in Grafted Autogenous Bone During Edgewise Treatment in Patients With Unilateral Cleft Lip/Palate or Alveolus. ( 24047436 )
2013
48
Registries of cleft lip/palate cases between 2004 and 2010 in Denizli, Turkey. ( 23479145 )
2013
49
Preoperative lip measurement in patients with complete unilateral cleft lip/palate and its comparison with norms. ( 23276499 )
2013
50
Cleft lip/palate associated with 17p13.3 duplication involving a single candidate gene (YWHAE). ( 23901910 )
2013

Variations for Cleft Lip/palate

Expression for Cleft Lip/palate

Search GEO for disease gene expression data for Cleft Lip/palate.

Pathways for Cleft Lip/palate

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 centriole GO:0005814 9.5 CEP120 KIAA0586 WDR34
2 ciliary basal body GO:0036064 9.43 IFT172 KIAA0586 WDR34
3 cytoplasmic dynein complex GO:0005868 9.37 TCTEX1D2 WDR34
4 apical junction complex GO:0043296 9.16 CDH1 NECTIN1
5 axoneme GO:0005930 9.13 IFT172 TCTEX1D2 WDR34
6 catenin complex GO:0016342 8.62 CDH1 NECTIN1

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 BMP4 CDH1 IRF6 TP63 YAP1
2 smoothened signaling pathway GO:0007224 9.58 BMP4 IFT172 KIAA0586
3 odontogenesis of dentin-containing tooth GO:0042475 9.54 BMP4 MSX1 TP63
4 middle ear morphogenesis GO:0042474 9.52 FGFR1 MSX1
5 anatomical structure formation involved in morphogenesis GO:0048646 9.51 BMP4 TP63
6 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.49 BMP4 MSX1
7 smooth muscle tissue development GO:0048745 9.48 BMP4 TP63
8 keratinocyte proliferation GO:0043616 9.46 IRF6 TP63
9 organ induction GO:0001759 9.43 BMP4 FGFR1
10 cilium assembly GO:0060271 9.35 IFT172 KIAA0586 NEK1 TCTEX1D2 WDR34
11 pituitary gland development GO:0021983 9.33 BMP4 CDH1 MSX1
12 BMP signaling pathway involved in heart development GO:0061312 9.32 BMP4 MSX1
13 cloacal septation GO:0060197 9.26 BMP4 TP63
14 embryonic limb morphogenesis GO:0030326 8.92 BMP4 FGFR1 MSX1 TP63

Sources for Cleft Lip/palate

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