MCID: CLF004
MIFTS: 49

Cleft Lip/palate

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip/palate

Summaries for Cleft Lip/palate

MedlinePlus : 40 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and short-rib thoracic dysplasia 12. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Adherens junction. The drugs leucovorin and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and heart, and related phenotypes are growth/size/body region and craniofacial

Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 34.8 EEC1 TP63
2 short-rib thoracic dysplasia 12 32.2 NEK1 WDR19
3 short-rib thoracic dysplasia 3 with or without polydactyly 32.2 NEK1 TCTEX1D2 WDR19 WDR34
4 short-rib thoracic dysplasia 1 with or without polydactyly 32.1 CEP120 WDR19 WDR34
5 isolated cleft lip 30.6 IRF6 MSX1 NECTIN1 TP63
6 cleft lip 29.6 ARHGAP29 BMP4 DLX4 EEC1 FGFR1 IRF6
7 tooth agenesis 29.2 BMP4 CDH1 FGFR1 IRF6 MSX1 TGFA
8 cleft palate, isolated 28.8 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
9 ankyloblepharon-ectodermal defects-cleft lip/palate 12.7
10 cleft lip/palate-ectodermal dysplasia syndrome 12.7
11 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.7
12 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.6
13 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.5
14 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.4
15 cleft lip/palate with abnormal thumbs and microcephaly 12.3
16 polydactyly cleft lip palate psychomotor retardation 12.3
17 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.3
18 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.3
19 holoprosencephaly ectrodactyly cleft lip palate 12.2
20 lagophthalmia cleft lip palate 12.2
21 amelia cleft lip palate hydrocephalus iris coloboma 12.2
22 radius, aplasia of, with cleft lip/palate 12.2
23 anophthalmia cleft lip palate hypothalamic disorder 12.2
24 cleft lip palate dysmorphism kumar type 12.2
25 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.2
26 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.2
27 cleft lip palate oligodontia syndactyly pili torti 12.2
28 tibial hemimelia cleft lip palate 12.2
29 cleft lip palate pituitary deficiency 12.2
30 cleft lip palate-tetraphocomelia 12.2
31 craniosynostosis cleft lip palate arthrogryposis 12.2
32 cleft lip/palate-deafness-sacral lipoma syndrome 12.2
33 popliteal pterygium syndrome 12.1
34 hartsfield syndrome 12.0
35 rapp-hodgkin syndrome 12.0
36 vici syndrome 11.9
37 acrofrontofacionasal dysostosis 11.9
38 cleft palate, cardiac defects, and mental retardation 11.8
39 zlotogora syndrome 11.8
40 richieri-costa/guion-almeida syndrome 11.7
41 uveal coloboma-cleft lip and palate-intellectual disability 11.7
42 martinez monasterio pinheiro syndrome 11.5
43 kapur-toriello syndrome 11.4
44 roberts syndrome 11.4
45 orofaciodigital syndrome vi 11.4
46 medeira-dennis-donnai syndrome 11.3
47 sakoda complex 11.3
48 acrofrontofacionasal dysostosis 1 11.3
49 crane-heise syndrome 11.3
50 short-rib thoracic dysplasia 7 with or without polydactyly 11.2

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate

Symptoms & Phenotypes for Cleft Lip/palate

MGI Mouse Phenotypes related to Cleft Lip/palate:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.31 BMP4 CDH1 CEP120 FGFR1 IRF6 KIAA0586
2 craniofacial MP:0005382 10.24 BMP4 FGFR1 IRF6 KIAA0586 MEIS2 MSX1
3 embryo MP:0005380 10.23 KIAA0586 MEIS2 MID1 MSX1 TP63 WDR19
4 cardiovascular system MP:0005385 10.21 CDH1 CEP120 FGFR1 KIAA0586 MEIS2 MSX1
5 digestive/alimentary MP:0005381 10.18 BMP4 CDH1 FGFR1 IRF6 MEIS2 MSX1
6 mortality/aging MP:0010768 10.1 CEP120 FGFR1 IRF6 KIAA0586 MEIS2 MID1
7 integument MP:0010771 10.07 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
8 hearing/vestibular/ear MP:0005377 9.88 BMP4 FGFR1 IRF6 MEIS2 MSX1 WDR19
9 limbs/digits/tail MP:0005371 9.87 BMP4 FGFR1 IRF6 KIAA0586 MSX1 TP63
10 muscle MP:0005369 9.76 BMP4 FGFR1 MID1 MSX1 TGFA TP63
11 skeleton MP:0005390 9.73 NECTIN1 NEK1 TCTEX1D2 TGFA TP63 WDR19
12 vision/eye MP:0005391 9.23 MSX1 NECTIN1 TGFA TP63 WDR19 BMP4

Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
3 Micronutrients Phase 3
4 Trace Elements Phase 3
5 Hematinics Phase 3
6 Vitamin B Complex Phase 3
7 Vitamins Phase 3
8 Folate Nutraceutical Phase 3
9 Vitamin B9 Nutraceutical Phase 3
10
Acetaminophen Approved Phase 2 103-90-2 1983
11
Acetylcholine Approved Phase 1, Phase 2 51-84-3 187
12
Dexmedetomidine Approved, Vet_approved Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
13
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
14 Analgesics Phase 2
15 Central Nervous System Depressants Phase 2
16 Anesthetics Phase 2
17 Peripheral Nervous System Agents Phase 1, Phase 2
18 abobotulinumtoxinA Phase 1, Phase 2
19 Adrenergic Agents Phase 2
20 Adrenergic Agonists Phase 2
21 Adrenergic alpha-2 Receptor Agonists Phase 2
22 Adrenergic alpha-Agonists Phase 2
23 Cholinergic Agents Phase 1, Phase 2
24 Neuromuscular Agents Phase 1, Phase 2
25 Neurotransmitter Agents Phase 1, Phase 2
26 Analgesics, Non-Narcotic Phase 2
27 onabotulinumtoxinA Phase 1, Phase 2
28 Anesthetics, Local Phase 2
29 Hypnotics and Sedatives Phase 2
30 Antipyretics Phase 2
31 Botulinum Toxins Phase 1, Phase 2
32 Botulinum Toxins, Type A Phase 1, Phase 2
33
Morphine Approved, Investigational 57-27-2 5288826
34
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
35 Adjuvants, Anesthesia
36 Narcotics
37 Analgesics, Opioid
38 Anesthetics, General
39 Anesthetics, Intravenous

Interventional clinical trials:

(show all 44)

# Name Status NCT ID Phase Drugs
1 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811 Phase 2, Phase 3
2 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
3 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
4 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
5 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
6 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
7 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
8 Suprazygomatic Block in Cleft Palate Surgery in Children Recruiting NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
9 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623
10 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998
11 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
12 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
13 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
14 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
15 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164
16 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
17 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
18 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509
19 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 MORPHINE PLUS FENTANYL;Fentanyl
20 Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations Completed NCT03395015
21 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
22 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
23 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
24 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
25 Tympanometric Analysis in Cleft Palate Completed NCT01820689
26 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
27 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
28 Child and Infant Learning Project Completed NCT00077831
29 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
30 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Recruiting NCT03029195
31 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Recruiting NCT02881606
32 Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants Recruiting NCT02845193
33 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686
34 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
35 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
36 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207
37 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Recruiting NCT02900014
38 Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study Recruiting NCT03165331
39 Follow Ups of Parents With Infants With Cleft Lip and Palate Active, not recruiting NCT02415361
40 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Not yet recruiting NCT03011489
41 Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate Not yet recruiting NCT03219021
42 the Relationship Between Cleft Lip and / or Palate (Different Types) and ABO Blood Groups. Not yet recruiting NCT03217890
43 TWIST Human Gene and Cleft Lips and Palates Terminated NCT00213889
44 The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair Withdrawn NCT02688634 Amoxicillin

Search NIH Clinical Center for Cleft Lip/palate

Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 28

Anatomical Context for Cleft Lip/palate

MalaCards organs/tissues related to Cleft Lip/palate:

38
Bone, Skin, Heart

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

(show top 50) (show all 151)
# Title Authors Year
1
PVR/CD155 Ala67Thr Mutation and Cleft Lip/Palate. ( 29381645 )
2018
2
Strong Association of C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene With Nosyndromic Cleft Lip/Palate (nsCL/P). ( 29371764 )
2018
3
A Pediatrician's Guide to Communication Disorders Secondary to Cleft Lip/Palate. ( 29173718 )
2018
4
Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology. ( 29026689 )
2017
5
Policy on the Management of Patients with Cleft Lip/Palate and Other Craniofacial Anomalies. ( 29179385 )
2017
6
SIBLINGS AFFECTED BY ECTRODACTYLY-ECTODERMAL DYSPLASIA AND CLEFT LIP/PALATE (EEC) SYNDROME PRESENTING NORMAL PARENTS: GERMLINE MOSAICISM? ( 28977327 )
2017
7
Establishing Content Validity of the CLEFT-Q: A New Patient-reported Outcome Instrument for Cleft Lip/Palate. ( 28507866 )
2017
8
Cone beam computed tomography imaging of superior semicircular canal morphology: a retrospective comparison of cleft lip/palate patients and normal controls. ( 29202612 )
2017
9
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome. ( 28230601 )
2017
10
Genitourinary malformations: an under-recognized feature of ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome. ( 28166087 )
2017
11
The study of association between reduced folate carrier 1 (<i>RFC1</i>) polymorphism and non-syndromic cleft lip/palate in Iranian population. ( 29435434 )
2017
12
Three-dimensional printed haptic model from a prenatal surface-rendered oropalatal sonographic view: a new tool in the surgical planning of cleft lip/palate. ( 28673724 )
2017
13
Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients After Primary Cheiloplasty Without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. ( 28085515 )
2017
14
The Serological Evidence of Cytomegalovirus Infection as a Potent Aetiological Factor for Cleft Lip/Palate, Mental Retardation and Deafness. ( 28764293 )
2017
15
Subcutaneous C Shape Muscular Flap for Correcting the Depression of Alar Base in Affected Side in Patients With Unilateral Complete Cleft Lip/Palate During Primary Surgery. ( 28230602 )
2017
16
Examination of Nasolacrimal Duct Morphometry Using Cone Beam Computed Tomography in Patients With Unilateral Cleft Lip/Palate. ( 28891896 )
2017
17
Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate. ( 28767310 )
2017
18
3D analysis of effects of primary surgeries in cleft lip/palate children during the first two years of life. ( 28591242 )
2017
19
Policy on Management of Patients with Cleft Lip/Palate and Other Craniofacial Anomalies. ( 27931481 )
2016
20
Time trend of incidence rates of cleft lip/palate in Taiwan from 1994 to 2013. ( 27372171 )
2016
21
Cleft characteristics and treatment outcomes in hemifacial microsomia compared to non-syndromic cleft lip/palate. ( 26775633 )
2016
22
Suboptimal Performance in Cleft Lip/Palate Children- Who is Responsible? ( 27891420 )
2016
23
Novel variant in the TP63 gene associated to ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome. ( 27485918 )
2016
24
MSX1 gene polymorphisms in Mexican patients with non-syndromic cleft lip/palate. ( 27729116 )
2016
25
ICD-10-based expanded code set for use in cleft lip/palate research and surveillance. ( 27891780 )
2016
26
Recurrence of split hand/foot malformation, cleft lip/palate, and severe urogenital abnormalities due to germline mosaicism for TP63 mutation. ( 27351625 )
2016
27
Chinese children with nonsyndromic cleft lip/palate: Factors associated with hearing disorder. ( 27497398 )
2016
28
Fetal Cleft Lip/Palate Surgery: End of a Dream? ( 27115723 )
2016
29
Computer-Assisted Orthognathic Surgery for Patients with Cleft Lip/Palate: From Traditional Planning to Three-Dimensional Surgical Simulation. ( 27002726 )
2016
30
Prenatal diagnosis of cleft lip/palate: The surface rendered oro-palatalA (SROP) view of the fetal lips and palate, a tool to improve information-sharing within the orofacial team and with the parents. ( 27211349 )
2016
31
Factors contributing to hearing impairment in patients with cleft lip/palate in Malaysia: A prospective study of 346 ears. ( 27497393 )
2016
32
Five-year speech and language outcomes in children with cleft lip-palate. ( 27614545 )
2016
33
Management of feeding Problem in a Patient with Cleft Lip/Palate. ( 27365936 )
2016
34
Comparison of dental arch dimensions in models of preschool children with cleft lip/palate repaired by means of surgery alone versus controls. ( 27749647 )
2016
35
Modified Activation Technique for Nasal Stent of Nasoalveolar Molding Appliance for Columellar Lengthening in Bilateral Cleft Lip/Palate. ( 27002917 )
2016
36
Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model. ( 27927890 )
2016
37
Gene Interactions Provide Evidence for Signaling Pathways Involved in Cleft Lip/Palate in Humans. ( 27154735 )
2016
38
Tomographic Pharyngeal Dimensions in Individuals With Unilateral Cleft Lip/Palate and Class III Malocclusion Are Reduced When Compared With Controls. ( 27148639 )
2016
39
Cleft lip/palate, short stature, and developmental delay in a boy with a 5.6-mb interstitial deletion involving 10p15.3p14. ( 25852446 )
2015
40
IRF6 Is a Marker of Severity in Nonsyndromic Cleft Lip/Palate. ( 25896061 )
2015
41
ALOBAR HOLOPROSENCEPHALY, CLEFT LIP/PALATE, URORECTAL SEPTUM MALFORMATION SEQUENCE AND CONGENITAL PERINEAL HERNIA IN A FETUS. ( 26625663 )
2015
42
Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate. ( 26199944 )
2015
43
A novel c.1037C > G (p.Ala346Gly) mutation in TP63 as cause of the ectrodactyly-ectodermal dysplasia and cleft lip/palate (EEC) syndrome. ( 25983622 )
2015
44
Evaluation of Delayed Puberty in Adolescents With Cleft Lip/Palate. ( 26506041 )
2015
45
Novel homozygous mutation, c.400C>T (p.Arg134*), in the PVRL1 gene underlies cleft lip/palate-ectodermal dysplasia syndrome in an Asian patient. ( 25913853 )
2015
46
Clinician's Primer to ICD-10-CM Coding for Cleft Lip/Palate Care. ( 26523325 )
2015
47
Further evidence suggesting a role for variation in ARHGAP29 variants in nonsyndromic cleft lip/palate. ( 25163644 )
2014
48
Enhancing accessibility of patients with cleft lip/palate to healthcare services via a cleft birth registration system. ( 25816535 )
2014
49
Functional Significance of MMP3 and TIMP2 Polymorphisms in Cleft Lip/Palate. ( 24799419 )
2014
50
A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk. ( 24528994 )
2014

Variations for Cleft Lip/palate

Expression for Cleft Lip/palate

Search GEO for disease gene expression data for Cleft Lip/palate.

Pathways for Cleft Lip/palate

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 centriole GO:0005814 9.33 CEP120 KIAA0586 WDR34
2 cytoplasmic dynein complex GO:0005868 9.26 TCTEX1D2 WDR34
3 apical junction complex GO:0043296 8.96 CDH1 NECTIN1
4 catenin complex GO:0016342 8.62 CDH1 NECTIN1

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 BMP4 CDH1 IRF6 TP63 YAP1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.99 BMP4 DLX4 FGFR1 MEIS2 MSX1 TP63
3 keratinocyte differentiation GO:0030216 9.7 IRF6 TP63 YAP1
4 smoothened signaling pathway GO:0007224 9.65 BMP4 KIAA0586 WDR19
5 cell morphogenesis GO:0000902 9.63 MSX1 WDR19 YAP1
6 camera-type eye morphogenesis GO:0048593 9.6 BMP4 NECTIN1
7 middle ear morphogenesis GO:0042474 9.58 FGFR1 MSX1
8 anatomical structure formation involved in morphogenesis GO:0048646 9.58 BMP4 TP63
9 odontogenesis of dentin-containing tooth GO:0042475 9.58 BMP4 MSX1 TP63
10 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.57 BMP4 MSX1
11 keratinocyte proliferation GO:0043616 9.56 IRF6 TP63
12 smooth muscle tissue development GO:0048745 9.55 BMP4 TP63
13 organ induction GO:0001759 9.54 BMP4 FGFR1
14 paraxial mesoderm development GO:0048339 9.49 FGFR1 YAP1
15 bud elongation involved in lung branching GO:0060449 9.43 BMP4 YAP1
16 pituitary gland development GO:0021983 9.43 BMP4 CDH1 MSX1
17 BMP signaling pathway involved in heart development GO:0061312 9.37 BMP4 MSX1
18 cilium assembly GO:0060271 9.35 KIAA0586 NEK1 TCTEX1D2 WDR19 WDR34
19 embryonic hindlimb morphogenesis GO:0035116 9.33 BMP4 MSX1 TP63
20 cloacal septation GO:0060197 9.32 BMP4 TP63
21 embryonic limb morphogenesis GO:0030326 9.02 BMP4 FGFR1 MSX1 TP63 WDR19

Molecular functions related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.02 DLX4 IRF6 MEIS2 MSX1 TP63

Sources for Cleft Lip/palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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