MCID: CLF002
MIFTS: 59

Cleft Palate malady

Summaries for Cleft Palate

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Cleft lip (cheiloschisis) and cleft palate (palatoschisis), which can also occur together as cleft lip... more...

MalaCards: Cleft Palate, also known as uranostaphyloschisis, is related to cleft lip and van der woude syndrome. An important gene associated with Cleft Palate is TBX22 (T-box 22), and among its related pathways are PAK Pathway and NF-KappaB Family Pathway. The compounds retinoic acid and thymidine have been mentioned in the context of this disorder. Affiliated tissues include bone, tongue and heart, and related mouse phenotypes are craniofacial and mortality/aging.

Description from OMIM:46 119540

Aliases & Classifications for Cleft Palate

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8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 60UMLS, 56SNOMED-CT, 46OMIM, 39NCIt, 34MeSH
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Aliases & Descriptions:

cleft palate 8 10 44
uranostaphyloschisis 8
palatoschisis 8


External Ids:

Disease Ontology8 DOID:674
ICD9CM27 749.0, 749.00
OMIM46 119540
NCIt39 C87069
MeSH34 D002972

Related Diseases for Cleft Palate

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17GeneCards, 18GeneDecks
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Diseases in the Cleft Palate family:

Dominant Cleft Palate

Diseases related to Cleft Palate via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 510)
idRelated DiseaseScoreTop Affiliating Genes
1cleft lip31.7TGFB3, TGFA, TP63, MSX1, FGFR1, TBX10
2van der woude syndrome30.4IRF6
3choanal atresia30.4FOXE1
4bamforth-lazarus syndrome30.2FOXE1, HOXA2
5syndactyly30.1TP63
6synostosis29.9BMP4, FGFR1, MSX1
7adult syndrome29.9TP63
8meningioma29.9TGFA
9cleft palate and mental retardation10.5
10cleft lip +/- cleft palate10.5
11omphalocele cleft palate syndrome lethal10.5
12ankyloblepharon filiforme adnatum cleft palate10.5
13cleft hard palate10.4
14microcephaly10.4
15stickler syndrome10.4
16middle ear disease10.4
17mesomelic dwarfism cleft palate camptodactyly10.4
18cleft velum10.4
19nasopharyngitis10.4
20otitis media10.4
21meningocele10.3
22hypervitaminosis a10.3
23klippel-feil syndrome10.3
24pseudohypoaldosteronism type ii10.3
25say syndrome10.3
26cleft palate stapes fixation oligodontia10.3
27cleft palate x-linked10.3
28dysmorphism cleft palate loose skin10.3
29palant cleft palate syndrome10.3
30cleft palate with ankyloglossia10.3
31spondyloepiphyseal dysplasia congenita10.3
32renpenning syndrome10.3
33beckwith-wiedemann syndrome10.3
34acromegaloid features, overgrowth, cleft palate and hernia10.3
35stickler syndrome type 110.3
36hardikar syndrome10.3
37cleft palate short stature vertebral anomalies10.3
38ectrodactyly cleft palate syndrome10.3
39femoral facial syndrome10.3
40macrosomia with lethal microphthalmia10.3
41oto-palato-digital syndrome type 110.3
42syngnathia cleft palate10.3
43microtia, hearing impairment, and cleft palate10.3
44submucosal cleft palate10.3
45schilbach-rott syndrome10.3
46diastrophic dysplasia10.2
47dandy-walker syndrome10.2
48diamond-blackfan anemia10.2
49congenital hypothyroidism10.2
50coloboma10.2

Graphical network of the top 20 diseases related to Cleft Palate:



Diseases related to cleft palate

Clinical Features for Cleft Palate

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46OMIM
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Clinical features from OMIM:

119540

Drugs & Therapeutics for Cleft Palate

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cleft Palate

Drug clinical trials:

Search ClinicalTrials for Cleft Palate

Search NIH Clinical Center for Cleft Palate

Search CenterWatch for Cleft Palate

Genetic Tests for Cleft Palate

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Anatomical Context for Cleft Palate

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32MalaCards
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MalaCards organs/tissues related to Cleft Palate:

32
Bone, Tongue, Heart, Skin, Testes, Thyroid, Lung, Eye, Kidney, Brain, Pituitary, Thymus, Liver, Breast, Testis

Animal Models for Cleft Palate or affiliated genes

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36MGI
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Publications for Cleft Palate

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50PubMed
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Articles related to Cleft Palate:

(show top 50)    (show all 1349)
idTitleAuthorsYear
1
Survey of analgesia for cleft lip and palate repair in the UK and Republic of Ireland. (24387152)
2014
2
Ultrasound Echo Imaging-Guided Surgery of Particulate Cancellous Bone and Marrow From the Iliac Crest for Cleft Palate. (23786530)
2013
3
Facial attractiveness of patients with unilateral cleft lip and palate and of controls assessed by laypersons and professionals. (23832974)
2013
4
Nasoalveolar molding with active columellar lengthening in severe bilateral cleft lip/palate: a clinical report. (22946934)
2013
5
ABM clinical protocol #18: guidelines for breastfeeding infants with cleft lip, cleft palate, or cleft lip and palate, revised 2013. (23886478)
2013
6
Maxillary reaction patterns identified by three-dimensional analysis of casts from infants with unilateral cleft lip and palate. (23807257)
2013
7
Maternal C677T MTHFR polymorphism and environmental factors are associated with cleft lip and palate in a Mexican population. (23787444)
2013
8
Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (23512105)
2013
9
The influence of socioeconomic status on oral health-related quality of life among Syrian children with cleft lip, or palate, or both. (23396466)
2013
10
Presurgical nasoalveolar molding for cleft lip and palate. (23852252)
2013
11
A longitudinal study of hearing and middle ear status in adolescents with cleft lip and palate. (23208794)
2013
12
Presurgical nasoalveolar molding (PNAM) for a unilateral cleft lip and palate: a clinical report. (22779947)
2013
13
The etiology of cleft palate formation in BMP7-deficient mice. (23516636)
2013
14
A randomized study of surgical site infiltration with bupivacaine or ketamine for pain relief in children following cleft palate repair. (23445320)
2013
15
Expanding the spectrum of microdeletion 4q21 syndrome: a partial phenotype with incomplete deletion of the minimal critical region and a new association with cleft palate and Pierre Robin sequence. (23913759)
2013
16
Examining markers in 8q24 to explain differences in evidence for association with cleft lip with/without cleft palate between Asians and Europeans. (22508319)
2012
17
Psychosocial effects of cleft lip and palate on Nigerians: the Ikeja-Lagos experience. (22455571)
2012
18
Use of folic acid supplements and risk of cleft lip and palate in infants: a population-based cohort study. (22781994)
2012
19
Growth modification in unilateral cleft lip and palate patients with face mask. (23961619)
2012
20
Acellular dermal matrix in cleft palate repair: an evidence-based review. (22743882)
2012
21
A descriptive epidemiologic study of cleft lip and palate in Spain. (23083948)
2012
22
Genetic and environmental factors in human cleft lip and palate. (22759667)
2012
23
2012 American Board of Pediatric Dentistry College of Diplomates annual meeting: the role of pediatric dentists in the presurgical treatment of infants with cleft lip/cleft palate utilizing nasoalveolar molding. (23387096)
2012
24
Telemedicine as a means of effective speech evaluation for patients with cleft palate. (22421491)
2012
25
Association between polymorphism of IRF6 rs2235371 locus and nonsyndromic cleft lip with or without cleft palate]. (22487822)
2012
26
Predictors of velopharyngeal insufficiency after Le Fort I maxillary advancement in patients with cleft palate. (21783004)
2011
27
No association between polymorphisms in cubilin, a gene of the homocysteine metabolism and the risk of non-syndromic cleft lip with or without cleft palate. (21781439)
2011
28
Reoperations in cleft lip and cleft palate treatment. (21272773)
2011
29
Satisfaction of speech and treatment for children with cleft lip/palate in Lao People's Democratic Republic. (22423414)
2011
30
Assessment of the posteroanterior cephalograms of the parents of children with cleft lip and/or cleft palate in Latvia. (21558785)
2011
31
Quality of life in patients with cleft lip and palate after operation. (22423427)
2011
32
Association of Wnt3A gene variants with non-syndromic cleft lip with or without cleft palate in Chinese population. (20932509)
2011
33
Zygomatic and maxillary implants inserted by means of computer-assisted surgery in a patient with a cleft palate. (20485069)
2010
34
Cleft extension and risks of other birth defects in children with isolated cleft palate. (19878042)
2010
35
Tongue suture placement after cleft palate repair. (20818261)
2010
36
Transforming growth factor-beta receptor type 1 (TGFBR1) is not associated with non-syndromic cleft lip with or without cleft palate in patients of Central European descent. (19586667)
2009
37
The common MTHFR C677T and A1298C variants are not associated with the risk of non-syndromic cleft lip/palate in northern Venezuela. (19447376)
2009
38
Excess maternal transmission of markers in TCOF1 among cleft palate case-parent trios from three populations. (18688869)
2008
39
The Walker-Warburg syndrome with cleft lip and palate. (17304384)
2007
40
Cleft lip and palate repair in Hay-Wells/ankyloblepharon-ectodermal dysplasia-clefting syndrome. (17477760)
2007
41
Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype. (16365259)
2005
42
Collagen XI sequence variations in nonsyndromic cleft palate, Robin sequence and micrognathia. (12673280)
2003
43
Cleft palate, hypotelorism, and hypospadias: Schilbach-Rott syndrome. (12400075)
2002
44
The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia. (11559848)
2001
45
Cleft palate lateral synechia syndrome. (11604632)
2001
46
Ectodermal dysplasia, cleft lip/palate, and severe cutaneous and osseous syndactyly in a mentally retarded girl: a new multiple malformation syndrome. (9188655)
1997
47
Anophthalmia, intracerebral cysts, and cleft lip/palate: expansion of the phenotype in oculocerebrocutaneous syndrome? (8986273)
1997
48
The Gordon syndrome: autosomal dominant cleft palate, camptodactyly, and club feet. (7258227)
1981
49
Cor pulmonale secondary to cleft palate repair. Case report. (850713)
1977
50
Spheno-pharyngeal meningocele and cleft palate. Case report with 12-year follow-up. (1060529)
1976

Genetic Variations for Cleft Palate

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Expression for genes affiliated with Cleft Palate

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cleft Palate

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Pathways for genes affiliated with Cleft Palate

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore
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Compounds for genes affiliated with Cleft Palate

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Cleft Palate according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.2BMP4, MTHFR, FGFR1, MSX1, TP63, TGFA
2thymidine44 2412.2TGFB3, TGFA, TP63, FGFR1, MTHFR, BMP4
3dopamine44 28 11 2414.0BMP4, MTHFR, FGFR1, TGFA, TGFB3
4estrogen4411.0BMP4, MTHFR, FGFR1, TP63, TGFA, TGFB3
5bromodeoxyuridine4411.0BMP4, FGFR1, TP63, TGFA
6ribonucleic acid4410.9BMP4, FGFR1, TGFA, TGFB3
7progesterone44 59 28 11 2414.8BMP4, FGFR1, TP63, TGFA, TGFB3
8steroid4410.8FGFR1, TP63, TGFA, TGFB3, BMP4
9multivitamin4410.8TGFA, MTHFR
10testosterone44 59 11 2413.7MTHFR, FGFR1, TP63, TGFA, TGFB3
11azathioprine44 49 2 1113.4TGFA, MTHFR, BMP4

GO Terms for genes affiliated with Cleft Palate

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16Gene Ontology
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Cellular components related to Cleft Palate according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.2TGFB3, LHX8, SATB2, IRF6, FOXE1, FOXC2
2transcription factor complexGO:00566710.8TP63, FOXC2, FOXE1, SATB2

Biological processes related to Cleft Palate according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:00012211.5TP63, UBB, SATB2, FOXE1, FOXC2, BMP4
2transcription, DNA-dependentGO:00635111.4LHX8, UBB, SATB2, IRF6, TBX22, TBX10
3positive regulation of transcription from RNA polymerase II promoterGO:04594411.3UBB, SATB2, FOXC2, BMP4, HOXA2, TP63
4positive regulation of transcription, DNA-dependentGO:04589311.2IRF6, FOXE1, FOXC2, BMP4, TP63, TGFB3
5negative regulation of apoptotic processGO:04306611.2UBB, FOXC2, BMP4, FGFR1, TP63, TGFA
6odontogenesis of dentin-containing toothGO:04247511.1LHX8, BMP4, MSX1, TP63
7ureteric bud developmentGO:00165710.9FOXC2, BMP4, FGFR1
8cloacal septationGO:06019710.9TP63, BMP4
9activation of MAPK activityGO:00018710.8UBB, TGFA, TGFB3
10positive regulation of SMAD protein import into nucleusGO:06039110.8TGFB3, BMP4
11embryonic viscerocranium morphogenesisGO:04870310.8HOXA2, FOXC2
12lens morphogenesis in camera-type eyeGO:00208910.7FOXE1, PVRL1
13keratinocyte proliferationGO:04361610.7TP63, IRF6
14positive regulation of collagen biosynthetic processGO:03296710.6TGFB3, BMP4
15smooth muscle tissue developmentGO:04874510.6TP63, BMP4
16Notch signaling pathwayGO:00721910.6UBB, FOXC2, TP63
17osteoblast developmentGO:00207610.3HOXA2, SATB2

Molecular functions related to Cleft Palate according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370011.1TP63, LHX8, SATB2, IRF6, FOXE1, FOXC2
2sequence-specific DNA bindingGO:04356510.7LHX8, SATB2, FOXE1, FOXC2, HOXA2, MSX1
3double-stranded DNA bindingGO:00369010.7TP63, FOXC2, FOXE1

Products for genes affiliated with Cleft Palate

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Sources for Cleft Palate

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet