Cleft Palate malady

Wikipedia: Cleft lip (cheiloschisis) and cleft palate (palatoschisis), which can also occur together as cleft lip...⁴⁴ more...

MalaCards: Cleft Palate, also known as uranostaphyloschisis (disorder), is related to cleft palate with ankyloglossia and cleft palate, isolated. An important gene associated with Cleft Palate is TBX22 (T-box 22), and among its related pathways are Ribosome and ILK Signaling. The compounds cycloheximide and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and thyroid, and related mouse phenotypes are growth/size and respiratory system.

Aliases & Descriptions:

cleft palate 6 7 8 32 uranostaphyloschisis (disorder) 6

palatoschisis 6

Diseases related to cleft palate by text searches and GeneDecks gene sharing:

(show top 50)    (show all 578)

id	Related Disease	Score	Top Affiliating Genes
1	cleft palate with ankyloglossia	35.0	CAPZA1P, TBX22, RPSAP15, KLHL4, CPXCR1
2	cleft palate, isolated	33.7	UBB, SATB2, FOXE1, C9orf156, HEMGN
3	cleft lip	33.1	RFC1, KIAA1598, NAT1, VAX1, BMP4, BMPR1A
4	van der woude syndrome	33.0	VWSM, IRF6, WDR65, TGFB3
5	pierre robin sequence	31.7	COL11A2, COL9A2, COL11A1, COL2A1, COL9A1, SOX9
6	amelia cleft lip palate hydrocephalus iris coloboma	31.2	BHMT, BAG4, MTHFR, LARGE, IRF6, FKRP
7	diamond-blackfan anemia	31.2	MTHFR, RPS26, RPL35A, RPS17, RPS24, RPS7
8	bamforth-lazarus syndrome	31.2	MSX1, FOXE1, HOXA2
9	orofacial cleft	30.4	NAT1, NAT2, BMP4, RARA, BHMT, BHMT2
10	walker-warburg syndrome	30.4	LARGE, FKRP, FKTN, POMT2, POMT1
11	syndactyly	30.3	MSX2, FGF10, FGFR1, FGFR2, TP63, NOG
12	strabismus	30.2	BMP4, FGFR2, COL11A1, COL2A1, COL9A1, DSPP
13	stickler syndrome	30.2	COL11A2, COL9A2, COL11A1, COL2A1, COL9A1
14	microtia	30.1	CDT1, CDC6, HOXA2, RPS19, TCOF1, ORC4
15	mental retardation syndrome	30.0	RAI1, BCOR, MTR, L1CAM, FLNA, FKRP
16	diastrophic dysplasia	29.2	BMP2, FN1, COL9A2, COL2A1, TGFB1, SLC26A2
17	choanal atresia	29.1	FOXE1, FGFR2, HOXA2, TCOF1, EFTUD2
18	hypodontia	28.9	PAX9, MSX1, MMP9, IRF6, FGF10, FGFR2
19	treacher collins syndrome	28.7	MSX2, HOXA2, RPL35A, RPL5, RPL11, TCOF1
20	short stature	28.7	RAI1, MRXSA, CDT1, CD36, CDC6, MMP13
21	prion disease	27.8	MTR, LARGE, MMP2, FKRP, FKTN, FGF2
22	osteoporosis	26.5	BMP2, BMP4, BMP6, MTHFR, SATB2, CD36
23	anemia	26.2	PCNA, BMP2, BMP6, BMPR1A, UBB, MTRR
24	congenital heart defect	26.0	MTHFR, CD36, MMP2, MMP3, MMP9, FN1
25	homocysteine	25.2	RFC1, PCNA, NAT1, NAT2, BHMT, BHMT2
26	glaucoma	25.2	BMP4, BMP6, BCOR, MTRR, MTHFR, MTR
27	thyroiditis	23.1	RFC1, PCNA, NAT2, BMP2, BMP6, BMPR1A
28	birth defects	14.3	BMP4, MTRR, MTHFR, MTR, MSX1, IRF6
29	muscular dystrophy-dystroglycanopathy	14.2	LARGE, FKRP, FKTN, POMT2, POMT1
30	lissencephaly	14.2	LARGE, FLNA, FKRP, FKTN, FGFR1, TCOF1
31	muscle-eye-brain disease	14.2	LARGE, FKRP, FKTN, POMT2, POMT1
32	amelogenesis imperfecta	14.1	MSX1, MSX2, MMP25, TP63, DLX3, DSPP
33	cerebellar hypoplasia	14.1	BMP2, BMP4, L1CAM, KAL1, FOXE1, FGF10
34	ectodermal dysplasia	14.1	MSX1, IRF6, FGF10, FGFR2, TP63, DLX3
35	tricho-dento-osseous syndrome	14.0	TP63, DLX3, DSPP
36	intellectual disability	14.0	RAI1, MTRR, MTR, L1CAM, FKRP, FKTN
37	vitamin b12 deficiency	14.0	MTHFR, MTR, TCN1, TCN2
38	macroglossia	14.0	COL11A2, COL11A1, COL2A1, COL9A1
39	neural tube defect	14.0	NAT1, MTRR, MTHFR, MTR, FOLR2, CBS
40	osteochondrodysplasia	14.0	FLNA, COL11A2, COL2A1, SOX9, SLC26A2
41	tooth agenesis	14.0	BMP4, PAX9, MSX1, MSX2, KAL1, CDH1
42	wagner syndrome	14.0	COL11A2, COL11A1, COL2A1
43	marshall syndrome	14.0	COL11A2, COL11A1, COL2A1
44	folic acid deficiency anemia	14.0	MTHFR, MTR, CBS, SLC19A1
45	homocysteinemia	14.0	MTRR, MTHFR, MTR, CBS, SLC19A1
46	synostosis	14.0	BMP2, BMP4, MSX1, MSX2, FMN1, FGF10
47	oligodontia	14.0	PAX9, BCOR, MSX1, DSPP
48	meier-gorlin syndrome	14.0	CDT1, CDC6, ORC4, ORC1, ORC6
49	intrauterine and postnatal growth retardation	14.0	CDT1, CDC6, ORC4, ORC1, ORC6
50	coloboma	14.0	VAX1, BMP4, BCOR, PQBP1, TFAP2A, TCOF1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cleft palate:

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MGI Mouse Phenotypes related to cleft palate:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	MYF5, BMP2, BMP4, BMP6, BMPR1A, RARA
2	respiratory system phenotype	MP:0005388	INF	MYF5, BMPR1A, RAI1, PAX9, MSX1, JAG2
3	craniofacial phenotype	MP:0005382	INF	VAX1, BMP4, BMPR1A, RAI1, PAX9,
4	skeleton phenotype	MP:0005390	INF	VAX1, MYF5, BMP2, BMP4, BMP6, BMPR1A
5	nervous system phenotype	MP:0003631	INF	VAX1, MYF5, BMP2, BMP4, BMPR1A, RARA
6	muscle phenotype	MP:0005369	INF	MYF5, BMP4, BMPR1A, RARA, PAX9, LARGE
7	hearing/vestibular/ear phenotype	MP:0005377	INF	BMP2, BMP4, BMPR1A, RARA, PAX9, LARGE
8	cardiovascular system phenotype	MP:0005385	INF	BMP2, BMP4, BMPR1A, RARA, , LARGE
9	no phenotypic analysis	MP:0003012	INF	PCNA, MYF5, BMP4, MTHFR, L1CAM, JAG2
10	endocrine/exocrine gland phenotype	MP:0005379	INF	BMPR1A, PAX9, SATB2, MSX1, MSX2, FGF10
11	normal phenotype	MP:0002873	INF	RBM10, NAT1, MYF5, BMP2, BMP4, BMPR1A
12	limbs/digits/tail phenotype	MP:0005371	INF	BMP2, BMP4, BMPR1A, RARA, RAI1, PAX9
13	behavior/neurological phenotype	MP:0005386	INF	MYF5, BMP4, BMPR1A, RAI1, PAX9, LHX8
14	tumorigenesis	MP:0002006	INF	MYF5, BMPR1A, RARA, BHMT, CDH1, MMP2
15	immune system phenotype	MP:0005387	INF	MYF5, BMPR1A, RARA, PAX9, BCL3, BAG4
16	integument phenotype	MP:0010771	INF	L1CAM, MSX1, MSX2, JAG2, MMP13, FOXE1
17	reproductive system phenotype	MP:0005389	INF	NAT1, BMP2, BMPR1A, RARA, PAX9, UBB
18	mortality/aging	MP:0010768	INF	VAX1, MYF5, BMP2, BMP4, BMPR1A, RAI1
19	renal/urinary system phenotype	MP:0005367	INF	BMP4, RARA, BHMT, , FOXC2, FMN1
20	vision/eye phenotype	MP:0005391	INF	NAT1, VAX1, MYF5, BMP4, BMPR1A, RARA
21	homeostasis/metabolism phenotype	MP:0005376	INF	NAT1, NAT2, MYF5, BMP2, BMP4, BMPR1A
22	embryogenesis phenotype	MP:0005380	INF	NAT1, MYF5, PAX9, , SATB2, MSX1
23	hematopoietic system phenotype	MP:0005397	INF	PCNA, BMP4, BMPR1A, PAX9, BCL3, BAG4
24	digestive/alimentary phenotype	MP:0005381	INF	VAX1, BMP2, BMP4, RARA, PAX9, LHX8
25	pigmentation phenotype	MP:0001186	INF	BMPR1A, L1CAM, MSX2, FOXC2, FMN1, FGFR2
26	cellular phenotype	MP:0005384	INF	PCNA, VAX1, MYF5, BMP2, BMP4, BMPR1A
27	liver/biliary system phenotype	MP:0005370	INF	BMP4, BHMT, CD36, FOXC2, , CBS

Articles related to cleft palate:

(show top 50)    (show all 151)

id	Title	Authors	Year	Affiliating Genes
1	No evidence for a role of CRISPLD2 in non-syndromic c left lip with or without cleft palate in an Italian population. (21244519)	Girardi A.... Scapoli L.	2011	CRISPLD2
2	Variation in FGF1, FOXE1, and TIMP2 genes is associat ed with nonsyndromic cleft lip with or without cleft palate. (21462296)	Nikopensius T.... Metspalu A.	2011	FGF1, TIMP2, FOXE1
3	Contribution of variants in and near the IRF6 gene to the risk of nonsyndromic cleft lip with or without cleft palate in a Malay pop ulation. (21834040)	Salahshourifar I.... Halim A.S.	2011	IRF6
4	Association of Wnt3A gene variants with non-syndromic cleft lip with or without cleft palate in Chinese population. (20932509)	Yao T.... Xie X.D.	2011	WNT3A
5	Transforming growth factor beta-3 and environmental f actors and cleft lip with/without cleft palate. (20408761)	Guo Z.... Gong B.	2010	TGFB3
6	MTHFR, TGFB3, and TGFA polymorphisms and their associ ation with the risk of non-syndromic cleft lip and cleft palate in China. (20082468)	Zhu J.... Li Z.	2010	TGFB3, MTHFR, TGFA
7	Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a Mesoamerican population: Evidence for IRF6 and var iants at 8q24 and 10q25. (20564431)	Rojas-Martinez A.... Mangold E.	2010	IRF6
8	Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice. (20424327)	Thomason H.A.... Dixon J.	2010	TP63, IRF6
9	p63 and IRF6: brothers in arms against cleft palate. (20424318)	Gritli-Linde A.	2010	TP63, IRF6
10	FOXE1 association with both isolated cleft lip with o r without cleft palate, and isolated cleft palate. (19779022)	Moreno L.M.... Lidral A.C.	2009	FOXE1, C9orf156, HEMGN
11	Non-syndromic cleft lip/cleft palate and C677T methy lene-tetrahydrofolate reductase variant in Mexican children]. (20550866)	DA!valos-RodrA-guez I.P.... Ledezma-GA^mez V.	2009	MTHFR
12	Transforming growth factor-beta receptor type 1 (TGFB R1) is not associated with non-syndromic cleft lip with or without cleft palate in patients of Central European descent. (19586667)	Reutter H.... Mangold E.	2009	TGFBR1
13	MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population. (19419265)	Ali A.... Raman R.	2009	MTHFR, IRF6
14	Evidence that TGFA influences risk to cleft lip with/ without cleft palate through unconventional genetic mechanisms. (19444471)	Sull J.W.... Beaty T.H.	2009	TGFA
15	Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. (19270707)	Birnbaum S.... Mangold E.	2009	IRF6, GSDMC, PVT1
16	Cleft palate in Pfeiffer syndrome. (19816260)	Stoler J.M.... Rogers G.F.	2009	FGFR1, FGFR2
17	Association between TGFB3 and nonsyndromic cleft lip with or without cleft palate in a Chilean population. (20170386)	Suazo J.... Blanco R.	2009	TGFB3
18	IRF6 gene variants in Central European patients with non-syndromic cleft lip with or without cleft palate. (20121942)	Birnbaum S.... Mangold E.	2009	IRF6
19	Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development. (19287188)	Jakobsen L.P.... Tommerup N.	2009	SPP1, SRGN
20	Walker-Warburg Syndrome with POMT1 mutations can be associated with cleft lip and cleft palate. (18640039)	Vajsar J.... Ray P.N.	2008	LARGE, POMT1, POMT2
21	Genes causing clefting syndromes as candidates for non-syndromic cleft lip with or without cleft palate: a family-based association study. (19049519)	Scapoli L.... Carinci F.	2008	JAG2, TP63, MID1
22	SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate. (18983974)	Song T.... Cao F.	2008	SUMO1
23	Association of bone morphogenetic protein 4 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate in Chinese children. (18771417)	Lin J.Y.... Luan R.S.	2008	BMP4
24	Study of the poliovirus receptor related-1 gene in Thai patients with non-syndromic cleft lip with or without cleft palate. (18356023)	Tongkobpetch S.... Shotelersuk V.	2008	PVRL1
25	Association of muscle segment homeobox gene 1 polymorphisms with nonsyndromic cleft lip with or without cleft palate (18705505)	Zhang L.... Liang S.Z.	2008	MSX1
26	Association of transforming growth factor-alpha gene polymorphism and environment factors with nonsyndromic cleft lip with or without cleft palate in Han nationality (17629209)	Yuan K.F.... Qin Y.F.	2007	TGFA
27	Genotype phenotype correlation of 30 patients with Smith-Magenis syndrome (SMS) using comparative genome hybridisation array: cleft palate in SMS is associated with larger deletions. (17468296)	Andrieux J.... Kerckaert J.P.	2007	UBB, RAI1
28	In vitro manipulation of cleft palate connective tissue: setting the bases of a proposed new treatment. (17173932)	Resel E.... MartA-nez-Alvarez C.	2007	BMP2
29	PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses. (16247549)	Ichikawa E.... Yoshiura K.	2006	TGFB3, PVRL1, PAX9
30	Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate. (16470748)	Martinelli M.... Carinci F.	2006	MTR, MTRR, TCN2
31	Association between parental transforming growth factor alpha gene TaqI variant, paternal smoking and the cleft lip with or without cleft palate (17313741)	Zhu J.H.... Li Z.	2006	TGFA
32	Relationship between transforming growth factor-alpha gene polymorphism and non-syndromic cleft lip with cleft palate (17334078)	Yuan K.F.... Zhou X.H.	2006	TGFA
33	Strong evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and nonsyndromic cleft lip with or without cleft palate, in an Italian population. (15558496)	Scapoli L.... Carinci F.	2005	IRF6
34	Possible association due to linkage disequilibrium of TGFA, RARA and BCL3 with nonsyndromic cleft lip with or without cleft palate in the Chilean population (16311697)	Suazo J.... Blanco R.	2005	RARA, TGFA, BCL3
35	Study of folate receptor genes in nonsyndromic familial and sporadic cleft lip with or without cleft palate cases. (15690375)	Scapoli L.... Carinci P.	2005	FOLR2
36	The TGF-alpha gene Taq I polymorphism and non-syndromic cleft lip with or without cleft palate (15449618)	Zhang W.G.... Liang J.	2004	TGFA
37	Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate. (15320969)	Tonacchera M.... Pinchera A.	2004	FOXE1, TTF2
38	Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. (12975342)	Ito Y.... Chai Y.	2003	TGFBR2
39	Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. (12374769)	Braybrook C.... Lindsay S.	2002	TBX22
40	Linkage disequilibrium between GABRB3 gene and nonsyndromic familial cleft lip with or without cleft palate. (11810291)	Scapoli L.... Carinci P.	2002	GABRB3
41	The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia. (11559848)	Braybrook C.... Stanier P.	2001	TBX22
42	Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region. (11499681)	Braybrook C.... Stanier P.	2001	KLHL4, CPXCR1, RPSAP15
43	Pathogenesis of cleft palate in TGF-beta3 knockout mice. (10433915)	Taya Y.... Ferguson M.W.	1999	TGFB3
44	Maternal vitamin use, infant C677T mutation in MTHFR, and isolated cleft palate risk. (10377018)	Shaw G.M.... Lammer E.J.	1999	MTHFR
45	A mouse model for hereditary thyroid dysgenesis and cleft palate. (9697704)	de Felice M.... Di Lauro R.	1998	FOXE1
46	Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome. (8651276)	Slaney S.F.... Wilkie A.O.	1996	FGFR2
47	Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. (7493022)	Kaartinen V.... Groffen J.	1995	TGFB3
48	Transforming growth factor alpha: a modifying locus for nonsyndromic cleft lip with or without cleft palate? (7834275)	Field L.L.... Marazita M.L.	1994	TGFA
49	The gene responsible for X-linked cleft palate (CPX) in a British Columbia native kindred is localized between PGK1 and DXYS1. (1570839)	Gorski S.M.... Goodfellow P.J.	1992	PGK1
50	Palmoplantar epidermal atrophy with hypokeratosis, d ys- and hypotrichosis, hypodontia, enamel and dentin hypoplasia, isolated cleft palate with cleft uvula, strabismus cryptorchism and other anomalies--an undes cribed ecto-mesodermal dysplasia? (1677642)	Salamon T.... Dojcinov D.	1991	DSPP

Genes related to cleft palate according to GeneCards:

(show top 50)    (show all 147)

id	Symbol	Description	Score	GeneCards Section Context
1	TBX22	T-box 22	11.1	Summaries, Publications, Aliases & Descriptions
2	FOXE1	forkhead box E1 (thyroid transcription factor 2)	11.1	Publications, Summaries
3	SATB2	SATB homeobox 2	11.1	Publications, Summaries
4	AOCH	Acromegaloid features, overgrowth, cleft palate, and hernia	11.1	Aliases & Descriptions
5	CPXCR1	CPX chromosome region, candidate 1	11.1	Summaries, Publications
6	MSX1	msh homeobox 1	11.1	Publications, Summaries
7	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	11.1	Publications, Summaries
8	LHX8	LIM homeobox 8	11.1	Publications, Summaries
9	TBX10	T-box 10	11.1	Publications, Summaries
10	ARVCF	armadillo repeat gene deleted in velocardiofacial syndrome	11.1	Summaries
11	IRF6	interferon regulatory factor 6	11.0	Publications
12	HOXA2	homeobox A2	11.0
13	TGFB3	transforming growth factor, beta 3	11.0	Publications
14	TGFA	transforming growth factor, alpha	11.0	Functions, Publications
15	UBB	ubiquitin B	11.0	Publications
16	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
17	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
18	TP63	tumor protein p63	11.0	Publications
19	CAPZA1P	capping protein (actin filament) muscle Z-line, alpha 1 pseudogene	11.0	Publications
20	RPSAP15	ribosomal protein SA pseudogene 15	11.0	Publications
21	HEMGN	hemogen	11.0	Publications
22	C9orf156	chromosome 9 open reading frame 156	11.0	Publications
23	BHMT	betaine--homocysteine S-methyltransferase	11.0	Publications
24	PHF8	PHD finger protein 8	11.0	Publications
25	BAG4	BCL2-associated athanogene 4	11.0	Publications
26	POMT1	protein-O-mannosyltransferase 1	11.0	Publications
27	FKRP	fukutin related protein	11.0	Publications
28	WDR65	WD repeat domain 65	11.0
29	COL11A2	collagen, type XI, alpha 2	11.0	Publications
30	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	11.0	Publications
31	TCOF1	Treacher Collins-Franceschetti syndrome 1	11.0	Publications
32	BMP4	bone morphogenetic protein 4	11.0	Publications
33	PGK1	phosphoglycerate kinase 1	11.0	Publications
34	POMT2	protein-O-mannosyltransferase 2	11.0	Publications
35	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	11.0	Publications
36	KLHL4	kelch-like 4 (Drosophila)	11.0	Publications
37	COL2A1	collagen, type II, alpha 1	11.0	Publications
38	FKTN	fukutin	11.0	Publications
39	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	11.0	Publications
40	COL11A1	collagen, type XI, alpha 1	11.0	Publications
41	L1CAM	L1 cell adhesion molecule	11.0
42	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Publications
43	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	11.0	Publications
44	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	11.0	Publications
45	RARA	retinoic acid receptor, alpha	11.0	Publications
46	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
47	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
48	BMP2	bone morphogenetic protein 2	11.0	Publications
49	DSPP	dentin sialophosphoprotein	11.0	Publications
50	FGFR2	fibroblast growth factor receptor 2	11.0	Publications

Pathways related to cleft palate according to GeneDecks:

(show top 50)    (show all 104)

id	Pathway	Score	Top Affiliating Genes
1	Ribosome20	INF	, RPL11, RPS15, RPL36, RPS19, RPS17
2	ILK Signaling36	INF	BMP2, BMP4, BMP6, CDH1, , FGF1
3	CFTR translational fidelity (class I mutations)41	INF	, , RPL11, RPS15, RPL36, RPL5
4	Actin-Based Motility by Rho Family GTPases36	10.6	TGFBR1, TGFB3, FGF10, BMP4
5	Hedgehog signaling pathway20	10.1	BMP6, WNT9B, BMP2, BMP4, WNT11, WNT3
6	Basal cell carcinoma20	9.9	WNT11, BMP4, WNT9B, BMP2, WNT3A, WNT3
7	CREB Pathway36	9.9	TIMP3, TGFBR1, BMP2, BMP4, TGFB3, FGF1
8	Glioma Invasiveness36	9.6	TGFA, FGF10, BMP2, BMP4, TGFB3, TIMP3
9	PPAR Pathway36	9.2	BMP2, BMP4, FGF1, FGF10, FGF2, FGFR1
10	eIF2 Pathway36	9.1	BMP6, FGF2, BMP4, FGFR1, FGF10, TGFB3
11	Paxillin Interactions36	9.0	BMP2, BMP4, FGFR1, FGF1, FGF10, FGFR2
12	Human Embryonic Stem Cell Pluripotency36	8.9	WNT5A, WNT3A, WNT3, TGFBR1, TGFB3, NOG
13	ERK5 Signaling36	8.7	FGFR1, EGFR, TIMP3, TGFA, FGF10, FGF1
14	NF-KappaB (p50-p65) Pathway36	8.3	FGF1, TGFB1, TGFA, TIMP3, TIMP2, FGFR2
15	NF-KappaB Family Pathway36	8.2	TGFB3, FGF10, BMP2, TGFB1, BMP4, BMP6
16	Apoptotic Pathways in Synovial Fibroblasts36	8.1	FGFR2, FGFR1, FGF2, FGF10, FGF1, EGFR
17	p53 Mediated Apoptosis36	8.1	BMP2, FGFR1, BMP6, FGF1, FGF10, BMP4
18	Telomerase Components in Cell Signaling36	8.1	BMP2, BMP6, FGF1, FGF10, BMP4, FGF2
19	Nuclear Receptor Activation by Vitamin-A36	8.1	TGFB1, TIMP3, TGFA, BMP6, RARA, TGFB3
20	Mitochondrial Apoptosis36	8.1	BMP4, FGF10, BMP6, FGF2, FGF1, TGFBR3
21	DHA Signaling36	8.1	TGFA, BMP4, FGF10, BMP2, FGF1, FGF2
22	Cellular Apoptosis Pathway36	8.1	BMP4, TGFB1, FGF1, TGFBR3, TGFB3, TGFBR1
23	Rac1 Pathway36	8.0	TGFB3, EGFR, TIMP2, TIMP3, TGFA, TGFB1
24	Colorectal Cancer Metastasis36	8.0	TGFBR2, TGFBR1, WNT3, WNT11, WNT5A, WNT7A
25	p70S6K Signaling36	8.0	FGFR1, FGF2, FGF10, TGFB1, FGF1, BMP4
26	Activation of PKC through GPCR36	7.9	TGFBR3, TGFB1, TGFB3, TGFBR1, BMP2, TGFA
27	Renin-Angiotensin Pathway36	7.9	TGFB3, BMP2, FGF1, FGF10, FGF2, FGFR1
28	Nanog in Mammalian ESC Pluripotency36	7.9	WNT8A, WNT7A, WNT5A, WNT3A, WNT3, BMP4
29	PAK Pathway36	7.9	TIMP3, MYH9, BMP2, BMP4, BMP6, FGF1
30	TGF-Beta Pathway36	7.7	TGFBR1, CDH1, FGFR1, FGF2, FGF10, FGF1
31	GSK3 Signaling36	7.5	FGF2, FGF10, FGF1, CDH1, BMP6, BMP4
32	Pancreatic Adenocarcinoma36	7.4	BMP6, FGF10, BMP2, TGFA, RYK, MMP2
33	MAPK Family Pathway36	7.4	TGFB1, BMP4, BMP6, FGF1, BMP2, FGF10
34	Pathways in cancer20	7.1	BMP4, WNT7A, WNT8A, WNT9B, WNT5A, WNT3A
35	Inhibition of Matrix Metalloproteinases36	INF	MMP9, , TIMP2, MMP25, MMP3, MMP2
36	Factors Promoting Cardiogenesis in Vertebrates36	INF	FGF2, TGFBR1, WNT11, BMP2, WNT3A, TGFBR2
37	Transcription Androgen Receptor nuclear signaling10	INF	TGFBR1, MMP2, , EGFR, TGFB1, TGFBR2
38	Phospholipase-C Pathway36	INF	TGFB3, EGFR, FGFR2, TGFBR3, , FGFR1
39	Epithelial Adherens Junctions36	INF	FGF2, TGFBR2, TGFBR3, MYH9, BMP6, CDH1
40	TGF-beta/Smad Signaling3	INF	PAX9, GREM1, , TGFBR3, BMP4, TGFB3
41	ERK Signaling36	INF	, FGFR2, FGFR1, FGF2, FGF10, FGF1
42	TGF-beta signaling pathway20	INF	BMP4, BMPR1A, DCN, TGFBR2, TGFBR1, TGFB3
43	Angiogenesis3	INF	TGFB3, TGFB1, TGFA, TIMP3, TIMP2,
44	Molecular Mechanisms of Cancer36	INF	FGF2, BMP2, BMP4, BMP6, BMPR1A, RARA
45	MAPK Signaling36	INF	, COL11A2, SPP1, , FGFR2, FGFR1
46	Rho Family GTPases36	INF	, FGF2, COL2A1, , EGFR, TIMP2
47	Transcription_Androgen Receptor nuclear signaling41	INF	TGFBR2, WNT9B, WNT7A, WNT8A, MMP2, WNT11
48	PTEN Pathway36	INF	BMP2, BMP4, FN1, FGF1, FGF2, FGFR1
49	Inhibition of Angiogenesis by TSP136	INF	TGFBR2, TGFBR1, TGFB3, TGFB1, COL2A1, COL11A1
50	Antioxidant Action of Vitamin-C36	INF	BMPR1A, TGFB3, FGFR2, BMP2, BMP4, BMP6

Compounds related to cleft palate according to GeneDecks:

(show top 50)    (show all 166)

id	Compound	Score	Top Affiliating Genes
1	cycloheximide32	INF	BMP2, BMP4, BMP6, RARA, CD36, MMP13
2	retinoic acid32 42 18	INF	MYF5, BMP2, BMP4, BMP6, RARA, RAI1
3	glutamine32	INF	PCNA, BMP6, MTR, CD36, CDH1, MMP3
4	heparin32 9 18 9	INF	BMP4, , CD36, CDH1, MMP13, MMP3
5	testosterone32 9 18 9	INF	PCNA, BMP2, RARA, MTHFR, CDH1, MMP2
6	ascorbic acid32 18	INF	PCNA, NAT1, BMP2, BMP4, MTHFR, CD36
7	pd 98,05932	INF	BMP2, BMP4, BMP6, RARA, CDH1, MMP13
8	heparan sulfate32 18	INF	BMP2, BMP4, BMP6, , FN1, FGF1
9	methylcobalamin32 18	11.2	MTRR, MTHFR, MTR, CBS, TCN1, TCN2
10	homocysteine32 18	10.7	NAT1, NAT2, BHMT, BHMT2, MTRR, MTR
11	progesterone32 42 9 18 9	13.6	PCNA, BMP2, BMP4, RARA, FGFR1, FGFR2
12	azathioprine32 34 9 9	12.3	PCNA, BMP2, BMP4, MTHFR, CDH1, MMP2
13	folate32	8.9	NAT1, NAT2, RARA, BHMT, MTRR, MTHFR
14	arginine32	8.9	RFC1, BMP2, RARA, FN1, GSTT1, FGF1
15	batimastat32 42 9 9	11.7	CD36, MMP13, MMP2, MMP25, MMP3, MMP9
16	12-o-tetradecanoylphorbol 13-acetate32	8.4	BMP6, RARA, CDH1, MMP13, MMP2, MMP3
17	hyaluronic acid32 18	9.4	BMP6, CD36, CDH1, MMP13, MMP3, FN1
18	bromodeoxyuridine32	8.4	PCNA, MYF5, BMP4, BMP6, FGF1, FGF10
19	glutamate32	8.0	PCNA, MYF5, BMP6, MTRR, MTHFR, MTR
20	troglitazone32 42 9 9	10.5	BMP6, RARA, CD36, CDH1, MMP2, MMP3
21	methotrexate32 34 42 9 9	11.5	PCNA, NAT2, BMP6, MTRR, MTHFR, MTR
22	cyclosporin a32 42	8.3	PCNA, BMP2, BMP4, BMP6, MTHFR, MMP3
23	paclitaxel32 34 9 9	10.1	PCNA, NAT1, BMP6, RARA, CDH1, FN1
24	lactate32	6.8	PCNA, BMP2, BMP6, CDH1, MMP2, MMP3
25	paraffin32	6.8	PCNA, CD36, MMP13, MMP2, FN1, GSTP1
26	creatinine32	6.1	PCNA, MYF5, BMP2, BMP6, MTHFR, MTR
27	alginate32	INF	BMP2, CD36, MMP13, MMP2, MMP3, FGF2
28	actinomycin d32	INF	BMP2, BMP4, RARA, MMP13, MMP9, FN1
29	tgf beta132	INF	BMP6, RARA, CD36, CDH1, MMP13, MMP2
30	dexamethasone32 42 34 9 9	INF	PCNA, NAT2, BMP2, BMP4, BMP6, RARA
31	herbimycin a32 42	INF	BMP6, CD36, CDH1, MMP13, MMP2, MMP9
32	matrigel32	INF	BMP2, BMP4, BMP6, CD36, CDH1, MMP13
33	ly29400232	INF	RARA, CDH1, MMP2, MMP9, FN1, FGF2
34	serine32	INF	MYF5, BMP2, BMP4, BMP6, BMPR1A, RARA
35	oligonucleotide32	INF	PCNA, NAT1, NAT2, BMP2, BMP4, BMP6
36	chondroitin sulfate32 18	INF	BMP6, CD36, MMP13, MMP3, FN1, FGF1
37	genistein32 9 18 9	INF	PCNA, BMP2, CD36, CDH1, MMP13, MMP2
38	sb 20358032 42	INF	BMP2, BMP4, BMP6, CD36, CDH1, MMP13
39	ribonucleic acid32	INF	BMP2, BMP4, BMP6, RARA, MMP13, MMP2
40	alanine32	INF	RFC1, PCNA, BMP2, BMP6, RARA, CDH1
41	nitric oxide32 9 18 9	INF	NAT1, NAT2, BMP2, BMP4, BMP6, MTRR
42	vegf32	INF	PCNA, BMP2, BMP4, BMP6, RARA, CD36
43	pge232	INF	BMP2, BMP4, CDH1, MMP13, MMP3, FN1
44	glycosaminoglycan32	INF	BMP2, CD36, MMP13, FGF1, FGF2, FGFR2
45	h2o232	INF	NAT1, FGFR2, CBS, , RPS27A, DSPP
46	procollagen32	INF	PCNA, BMP2, BMP6, CD36, MMP13, MMP2
47	estrogen32	INF	PCNA, NAT1, NAT2, BMP2, BMP4, BMP6
48	cysteine32	INF	PCNA, NAT1, NAT2, BMP4, RARA, MTHFR
49	vitamin d32	INF	BMP2, BMP6, RARA, MTHFR, CD36, CDH1
50	tyrosine32	INF	BMP2, BMP4, BMP6, RARA, BCL3, L1CAM

Cellular components related to cleft palate according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:005654	INF	RPS15, RPS27A, SKI, HEMGN, ,
2	extracellular space	GO:005615	INF	WNT8A, SPP1, NOG, COL2A1, EDN1, EGFR
3	cytosol	GO:005829	INF	, RPS17, , , , SPRY2
4	proteinaceous extracellular matrix	GO:005578	INF	TGFBR3, WNT11, WNT3, WNT3A, WNT5A, WNT7A
5	cell surface	GO:009986	INF	TGFA, TGFB1, TGFB3, TGFBR3, PVRL2, WNT3A
6	nucleus	GO:005634	INF	, , , , RPS7, RPL5
7	extracellular matrix	GO:031012	INF	TGFB3, DCN, TIMP3, CRISPLD2, , FGFR2
8	cytosolic small ribosomal subunit	GO:022627	INF	RPS27A, RPS15, RPS19, , RPS7,
9	extracellular region	GO:005576	INF	, COL2A1, COL11A1, , COL11A2,
10	origin recognition complex	GO:000808	INF	, ,

Biological processes related to cleft palate according to GeneDecks:

(show top 50)    (show all 107)

id	Name	GO ID	Score	Top Affiliating Genes
1	mRNA metabolic process	GO:016071	INF	RPS15, RPS27A, RPS17, , , UBB
2	positive regulation of epithelial cell proliferation	GO:050679	INF	NOG, EGFR, TGFA, TGFB1, , FGFR2
3	RNA metabolic process	GO:016070	INF	, , RPS17, , UBB, RPS19
4	negative regulation of transcription, DNA-dependent	GO:045892	INF	, PAX9, RARA, BMP4, BMP2, TP63
5	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	FOXE1, CD36, SATB1, MSX2, MSX1, SATB2
6	skeletal system development	GO:001501	INF	TP63, FGFR1, MMP9, JAG2, BMP6, BMP2
7	viral infectious cycle	GO:019058	INF	RPS17, , RPS7, RPL5, , RPS19
8	negative regulation of apoptotic process	GO:043066	INF	, CAT, FGFR1, FGF10, GSTP1, MSX2
9	positive regulation of cell proliferation	GO:008284	INF	, EDN1, GREM1, FGF2, FGF1, FGFR1
10	cellular response to retinoic acid	GO:071300	INF	, , WNT3, WNT3A, WNT5A, WNT9B
11	viral transcription	GO:019083	INF	RPS27A, RPS15, RPL36, , RPL5, RPS7
12	SRP-dependent cotranslational protein targeting to membrane	GO:006614	INF	RPL5, RPL11, , RPS27A, ,
13	translational elongation	GO:006414	INF	RPS17, , RPS7, , RPS19, RPL36
14	translational termination	GO:006415	INF	RPS7, RPL11, RPS15, RPL36, RPS19,
15	positive regulation of mesenchymal cell proliferation	GO:002053	INF	TGFBR2, , , TP63, BMPR1A, FGFR2
16	negative regulation of cell proliferation	GO:008285	INF	TIMP2, TGFB1, TFAP2A, SOX4, TGFB3, BMP2
17	embryonic cranial skeleton morphogenesis	GO:048701	INF	WNT9B, TFAP2A, TGFBR2, TGFBR1, , BMP4
18	translational initiation	GO:006413	INF	, RPS19, RPS27A, RPL5, , RPS7
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO:000184	INF	RPL11, RPS27A, RPS7, , RPS17,
20	skeletal system morphogenesis	GO:048705	10.4	FMN1, RYK, FGFR1, FGFR2, COL11A2, TGFBR1
21	osteoblast differentiation	GO:001649	10.4	MSX2, NOG, WNT3A, BMP4
22	methionine biosynthetic process	GO:009086	10.1	BHMT, BHMT2, MTRR, MTHFR
23	negative regulation of axon extension involved in axon guidance	GO:048843	10.0	WNT3, WNT5A, RYK, WNT3A
24	positive regulation of SMAD protein import into nucleus	GO:060391	9.8	BMPR1A, TGFB1, TGFB3, TGFBR1, BMP4
25	BMP signaling pathway	GO:030509	9.8	BMP2, BMP4, SKI, BMP6, TGFBR3, NOG
26	pathway-restricted SMAD protein phosphorylation	GO:060389	9.6	TGFBR3, TGFBR2, BMP2, TGFBR1, TGFB1
27	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	9.5	TGFBR1, BMP4, TGFB3, BMP2, BMP6, BMPR1A
28	cellular response to growth factor stimulus	GO:071363	9.5	BMP2, CAT, TGFB3, TGFB1, BMP4, PAX9
29	positive regulation of cell division	GO:051781	9.0	FGF2, FGFR2, CAT, TGFA, FGF1, TGFB1
30	middle ear morphogenesis	GO:042474	INF	EDN1, FGFR1, MSX1, HOXA2, , NOG
31	axon guidance	GO:007411	INF	KIAA1598, VAX1, WNT5A, WNT3A, L1CAM, WNT3
32	cartilage development	GO:051216	INF	, WNT5A, WNT7A, BMP2, EDN1, TGFBR2
33	extracellular matrix organization	GO:030198	INF	FOXF2, POMT1, , TIMP2, , MYF5
34	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	WNT7A, MYF5, TGFB1, , WNT5A, WNT3A
35	odontogenesis of dentin-containing tooth	GO:042475	INF	JAG2, MSX1, LHX8, BMPR1A, TP63, BMP4
36	positive regulation of bone mineralization	GO:030501	INF	BMPR1A, , TGFB1, BMP6, BMP4, TGFB3
37	ribosomal small subunit biogenesis	GO:042274	INF	RPS19, RPS7, RPS15, , RPS17
38	epithelial to mesenchymal transition	GO:001837	INF	TGFB1, TGFBR1, TGFBR3, , NOG, FOXF2
39	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	INF	TGFBR3, TGFBR1, TGFBR2, TGFB3, TGFB1, RPS27A
40	in utero embryonic development	GO:001701	INF	NOG, WNT3A, WNT9B, MYH9, TGFBR2, TGFBR1
41	positive regulation of transcription, DNA-dependent	GO:045893	INF	FOXE1, FOXF2, WNT5A, TGFB1, PHF8, TGFB3
42	chondrocyte differentiation	GO:002062	INF	BMP4, COL11A2, FGFR1, , TGFB1, COL2A1
43	inner ear morphogenesis	GO:042472	INF	COL2A1, SPRY2, TFAP2A, FGFR1, , MAFB
44	wound healing	GO:042060	INF	FGF10, TGFBR1, NOG, WNT5A, DCN, TGFA
45	gene expression	GO:010467	INF	, UBB, RPS15, RPL11, RPS27A, SKI
46	palate development	GO:060021	INF	BMPR1A, , SATB2, MSX1, FOXF2, SUMO1
47	transforming growth factor beta receptor signaling pathway	GO:007179	INF	TGFBR3, TGFBR2, TGFBR1, TGFB1, SKI, RPS27A
48	limb bud formation	GO:060174	INF	FGFR2, SOX4, , FGF10, WNT3, COL2A1
49	face morphogenesis	GO:060325	INF	PAX9, , NOG, SKI, MSX1, TGFB1
50	S phase of mitotic cell cycle	GO:000084	INF	RFC1, , , , RPS27A,

Molecular functions related to cleft palate according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent conferring tensile strength	GO:030020	INF	, COL2A1, , COL11A2
2	sequence-specific DNA binding	GO:043565	INF	, , HOXA2, MAFB, FOXF2, FOXE1
3	homocysteine S-methyltransferase activity	GO:008898	10.7	MTR, BHMT2, BHMT
4	receptor agonist activity	GO:048018	10.4	WNT8A, WNT7A, WNT5A, WNT3A, WNT3, GREM1
5	SMAD binding	GO:046332	10.2	TGFBR3, TGFBR2, TGFBR1, SKI, BMPR1A, BMP2
6	BMP receptor binding	GO:070700	10.2	BMP6, BMP4, BMP2
7	transforming growth factor beta binding	GO:050431	10.2	TGFBR3, TGFBR2, TGFBR1, TGFB3, CD36
8	transforming growth factor beta-activated receptor activity	GO:005024	10.2	BMPR1A, TGFBR1, TGFBR2, TGFBR3
9	type II transforming growth factor beta receptor binding	GO:005114	9.7	TGFB1, TGFB3, TGFBR1, TGFBR3
10	cytokine activity	GO:005125	9.2	WNT7A, WNT5A, EDN1, SPP1, GREM1, FGF2
11	protein domain specific binding	GO:019904	9.1	WNT5A, WNT3A, WNT3, SKI, FAF1, CDH1
12	growth factor activity	GO:008083	9.0	TGFB3, TGFB1, TGFA, FGF2, FGF10, FGF1
13	collagen binding	GO:005518	INF	DCN, DSPP, , SRGN, FN1, MMP9
14	structural constituent of ribosome	GO:003735	INF	RPS27A, RPL11, RPS15, RPL36, RPS19, RPL5
15	sequence-specific DNA binding transcription factor activity	GO:003700	INF	HOXA2, , TBX10, TBX22, DLX3,
16	heparin binding	GO:008201	INF	FGFR1, FGFR2, CRISPLD2, TGFBR3, FGF2, FGF10
17	protein binding	GO:005515	INF	MYH9, TIMP3, TTF2, HEMGN, EGFR, SKI
18	chromatin DNA binding	GO:031490	INF	, FOXC2, RARA, VAX1
19	protein homodimerization activity	GO:042803	INF	, NOG, TGFB1, TFAP2A, PVRL1, PVRL2