Cleft Palate, Isolated malady
Genetic diseases, Oral diseases, Fetal diseases, Rare diseases, Neuronal diseases, Mental diseases categories
Aliases & Descriptions for Cleft Palate, Isolated:
MalaCards categories: See all MalaCards categories (disease lists)
Global: Genetic diseases, Fetal diseases, Rare diseases
Anatomical: Oral diseases, Neuronal diseases, Mental diseases
ICD10: 28 27
Developmental anomalies during embryogenesis
Characteristics (Orphanet epidemiological data):51
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-5/10000 (Europe),1-5/10000 (Austria),1-5/10000 (Belgium),1-5/10000 (Croatia),>1/1000 (Denmark),1-5/10000 (France),1-5/10000 (Germany),6-9/10000 (Hungary),1-5/10000 (Ireland),1-5/10000 (Italy),6-9/10000 (Malta),1-5/10000 (Netherlands),6-9/10000 (Norway),1-5/10000 (Poland),1-5/10000 (Portugal),1-5/10000 (Spain),1-5/10000 (Switzerland),6-9/10000 (United Kingdom),1-5/10000 (Ukraine); Age of onset: Antenatal,Neonatal; Age of death: normal life expectancy
soft cleft palate:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Infancy,Neonatal
UniProtKB/Swiss-Prot:67 Cleft palate isolated: A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.
MalaCards based summary: Cleft Palate, Isolated, also known as cleft palate, is related to rapp-hodgkin syndrome and marshall syndrome, and has symptoms including non-midline cleft lip, autosomal dominant inheritance and cleft palate. An important gene associated with Cleft Palate, Isolated is UBB (Ubiquitin B), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and . Related mouse phenotypes are adipose tissue and hearing/vestibular/ear.
Disease Ontology:10 An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.
OMIM:49 Cleft palate as an isolated malformation behaves as an entity distinct from cleft lip with or without cleft palate (see... (119540) more...
Symptoms by clinical synopsis from OMIM:119540
Clinical features from OMIM:119540
HPO human phenotypes related to Cleft Palate, Isolated:(show all 9)
Drugs for Cleft Palate, Isolated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 29)
Interventional clinical trials:(show top 50) (show all 69)
Search NIH Clinical Center for Cleft Palate, Isolated
MGI Mouse Phenotypes related to Cleft Palate, Isolated:38 (show all 19)
Search GEO for disease gene expression data for Cleft Palate, Isolated.
Pathways related to Cleft Palate, Isolated according to GeneCards Suite gene sharing:(show all 12)
Cellular components related to Cleft Palate, Isolated according to GeneCards Suite gene sharing:
Biological processes related to Cleft Palate, Isolated according to GeneCards Suite gene sharing:(show top 50) (show all 79)
Molecular functions related to Cleft Palate, Isolated according to GeneCards Suite gene sharing:
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet