CPI
MCID: CLF027
MIFTS: 55

Cleft Palate, Isolated (CPI) malady

Categories: Oral diseases, Genetic diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Cleft Palate, Isolated

Aliases & Descriptions for Cleft Palate, Isolated:

Name: Cleft Palate, Isolated 54 24 69
Cleft Palate 12 29 52 42 14 69
Isolated Cleft Palate 12 14
Cleft Palate Isolated 66 29
Uranostaphyloschisis 12 69
Cleft Palate Isolated with Mental Retardation 66
Palatoschisis 12
Cleft Velum 12
Cpi 66
Cp 66

Characteristics:

HPO:

32
cleft palate, isolated:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Cleft Palate, Isolated

UniProtKB/Swiss-Prot : 66 Cleft palate isolated: A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.

MalaCards based summary : Cleft Palate, Isolated, also known as cleft palate, is related to orofacial cleft 6 and cleft lip +/- cleft palate, and has symptoms including seizures, gingival overgrowth and cleft palate. An important gene associated with Cleft Palate, Isolated is UBB (Ubiquitin B), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Tranexamic Acid and Codeine have been mentioned in the context of this disorder. Related phenotypes are craniofacial and growth/size/body region

Disease Ontology : 12 An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.

OMIM : 54 Cleft palate as an isolated malformation behaves as an entity distinct from cleft lip with or without cleft palate (see... (119540) more...

Related Diseases for Cleft Palate, Isolated

Diseases related to Cleft Palate, Isolated via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
id Related Disease Score Top Affiliating Genes
1 orofacial cleft 6 32.6 IRF6 SATB2 TP63
2 cleft lip +/- cleft palate 12.3
3 cleft palate with ankyloglossia 12.3
4 microtia, hearing impairment, and cleft palate 12.2
5 cleft palate, psychomotor retardation, and distinctive facial features 12.1
6 hydrocephalus-cleft palate-joint contractures syndrome 12.1
7 submucosal cleft palate 12.1
8 syngnathia cleft palate 12.0
9 cleft palate, cardiac defect, genital anomalies, and ectrodactyly 12.0
10 omphalocele-cleft palate syndrome, lethal 12.0
11 cleft palate x-linked 12.0
12 dominant cleft palate 11.9
13 ankyloblepharon filiforme adnatum and cleft palate 11.9
14 acromegaloid features, overgrowth, cleft palate, and hernia 11.9
15 cleft palate, midfacial hypoplasia, triangular facies, and sensorineural hearing loss 11.9
16 hydronephrosis, congenital, with cleft palate, characteristic facies, hypotonia, and mental retardation 11.9
17 palant cleft palate syndrome 11.9
18 native american myopathy 11.9
19 dysmorphism cleft palate loose skin 11.8
20 spondyloepiphyseal dysplasia with coronal craniosynostosis, cataracts, cleft palate, and mental retardation 11.8
21 hypotelorism cleft palate hypospadias 11.8
22 cleft palate short stature vertebral anomalies 11.8
23 cleft palate, deafness, and oligodontia 11.8
24 short stature monodactylous ectrodactyly cleft palate 11.8
25 craniosynostosis arthrogryposis cleft palate 11.8
26 cystic hygroma lethal cleft palate 11.8
27 anophthalmia cleft palate micrognathia 11.8
28 microcephaly-cleft palate syndrome 11.8
29 hirschsprung microcephaly cleft palate 11.8
30 blepharoptosis-cleft palate-ectrodactyly-dental anomalies syndrome 11.8
31 cleft palate cardiac defect ectrodactyly 11.8
32 auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome 11.8
33 cleft palate colobomata radial synostosis deafness 11.8
34 mesomelic dwarfism cleft palate camptodactyly 11.8
35 cleft palate heart disease polydactyly absent tibia 11.8
36 cleft palate stapes fixation oligodontia 11.8
37 short limbs subluxed knees cleft palate 11.8
38 cleft soft palate 11.8
39 syngnathia 11.7
40 cleft lip/palate 11.7
41 orofacial cleft 11 11.7
42 aceruloplasminemia 11.7
43 mandibulofacial dysostosis, guion-almeida type 11.7
44 pierre robin syndrome 11.6
45 abruzzo-erickson syndrome 11.6
46 bamforth-lazarus syndrome 11.6
47 arthrogryposis, distal, type 3 11.6
48 cleft lip/palate-ectodermal dysplasia syndrome 11.5
49 isolated pierre robin sequence 11.5
50 rapp-hodgkin syndrome 11.5

Graphical network of the top 20 diseases related to Cleft Palate, Isolated:



Diseases related to Cleft Palate, Isolated

Symptoms & Phenotypes for Cleft Palate, Isolated

Symptoms by clinical synopsis from OMIM:

119540

Clinical features from OMIM:

119540

Human phenotypes related to Cleft Palate, Isolated:

32 (show all 8)
id Description HPO Frequency HPO Source Accession
1 seizures 32 HP:0001250
2 gingival overgrowth 32 HP:0000212
3 cleft palate 32 HP:0000175
4 micrognathia 32 HP:0000347
5 non-midline cleft lip 32 HP:0100335
6 intellectual disability, profound 32 HP:0002187
7 overbite 32 HP:0011094
8 anterior open-bite malocclusion 32 HP:0009102

UMLS symptoms related to Cleft Palate, Isolated:


seizures

MGI Mouse Phenotypes related to Cleft Palate, Isolated:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.51 BMP4 COL11A1 COL11A2 COL2A1 FGFR1 FGFR2
2 growth/size/body region MP:0005378 10.49 BMP4 COL11A1 COL11A2 COL2A1 FGFR1 FGFR2
3 digestive/alimentary MP:0005381 10.45 BMP4 COL11A1 COL2A1 FGFR1 FGFR2 FOXC2
4 mortality/aging MP:0010768 10.33 IRF6 MSX1 MTHFR NECTIN1 SATB2 TBX22
5 homeostasis/metabolism MP:0005376 10.29 BMP4 COL2A1 FGFR1 FGFR2 FOXC2 FOXE1
6 embryo MP:0005380 10.28 BMP4 COL2A1 FGFR1 FGFR2 FOXC2 IRF6
7 cardiovascular system MP:0005385 10.27 MSX1 SATB2 TGFA TGFB3 TP63 BMP4
8 hearing/vestibular/ear MP:0005377 10.24 TCOF1 BMP4 COL11A1 COL11A2 COL2A1 FGFR1
9 endocrine/exocrine gland MP:0005379 10.18 BMP4 FGFR1 FGFR2 FOXE1 MSX1 SATB2
10 limbs/digits/tail MP:0005371 10.17 BMP4 COL11A1 COL2A1 FGFR1 FGFR2 IRF6
11 integument MP:0010771 10.16 BMP4 FGFR1 FGFR2 FOXE1 IRF6 MSX1
12 nervous system MP:0003631 10.11 BMP4 COL11A1 COL2A1 FGFR1 FGFR2 FOXC2
13 no phenotypic analysis MP:0003012 9.92 TP63 BMP4 FGFR1 FGFR2 FOXC2 GABRB3
14 normal MP:0002873 9.91 BMP4 COL2A1 FGFR1 FGFR2 FOXC2 GABRB3
15 respiratory system MP:0005388 9.9 TP63 BMP4 COL11A1 COL2A1 FGFR2 FOXC2
16 skeleton MP:0005390 9.89 TCOF1 TGFA TGFB3 TP63 BMP4 COL11A1
17 vision/eye MP:0005391 9.4 BMP4 COL2A1 FGFR1 FGFR2 FOXC2 MSX1

Drugs & Therapeutics for Cleft Palate, Isolated

Drugs for Cleft Palate, Isolated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4 1197-18-8 5526
2
Codeine Approved, Illicit Phase 4 76-57-3 5284371
3
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
4
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
8 Analgesics Phase 4,Phase 3,Phase 2
9 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
10 Narcotics Phase 4
11 Coagulants Phase 4
12 Hemostatics Phase 4
13 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
14 Analgesics, Opioid Phase 4
15 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1
16 Anesthetics, General Phase 4
17 Anesthetics, Intravenous Phase 4
18 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
19 Anti-Bacterial Agents Phase 4,Phase 2
20 Anti-Infective Agents Phase 4,Phase 2
21 Antifibrinolytic Agents Phase 4
22 Respiratory System Agents Phase 4
23 Antibiotics, Antitubercular Phase 4,Phase 2
24 Antitubercular Agents Phase 4,Phase 2
25 Antitussive Agents Phase 4
26 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
27 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
28 Anesthetics, Inhalation Phase 4
29 Hypnotics and Sedatives Phase 4
30 Platelet Aggregation Inhibitors Phase 4
31 Fibrin Tissue Adhesive Phase 4
32 Adrenergic Agents Phase 4
33 Adrenergic Agonists Phase 4
34 Adrenergic alpha-2 Receptor Agonists Phase 4
35 Adrenergic alpha-Agonists Phase 4
36
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
37
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
38
Ketorolac Approved Phase 3 74103-06-3, 66635-83-4 3826
39
Levobupivacaine Approved Phase 2, Phase 3 27262-47-1 92253
40
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
42 Cyclooxygenase Inhibitors Phase 3
43 Hematinics Phase 3
44 Trace Elements Phase 3
45 Anesthetics, Local Phase 2, Phase 3
46 Vitamin B Complex Phase 3
47 Epinephryl borate Phase 3
48 Pharmaceutical Solutions Phase 3,Phase 2
49 Vitamins Phase 3
50 Anti-Inflammatory Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 91)
id Name Status NCT ID Phase
1 Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants Completed NCT00386269 Phase 4
2 Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty Completed NCT02422056 Phase 4
3 The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair Recruiting NCT02688634 Phase 4
4 The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Recruiting NCT02953145 Phase 4
5 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4
6 Dexmedetomidine vs Placebo for Pediatric Cleft Palate Repair Not yet recruiting NCT02915042 Phase 4
7 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3
8 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3
9 Oral Cleft Prevention Program Completed NCT00397917 Phase 3
10 A Comparison of Bupivacaine and Ketorolac for Postoperative Analgesia After Iliac Crest Bone Harvesting Completed NCT00405262 Phase 3
11 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811 Phase 2, Phase 3
12 Phase II Study of Dietary Cholesterol for Smith-Lemli-Opitz Syndrome Unknown status NCT00004347 Phase 2
13 Preoperative Antibiotics Study Completed NCT00760006 Phase 2
14 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
15 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
16 Cell Therapy for Craniofacial Bone Defects Completed NCT01616953 Phase 1, Phase 2
17 Does Use of Rigid Fixation After Removing Distraction Osteogenesis Device Reduce the Relapse? Completed NCT02350803 Phase 2
18 Short-term Behavioral Effects of Cholesterol Therapy in Smith-Lemli-Opitz Syndrome Completed NCT00114634 Phase 2
19 Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome Completed NCT00272844 Phase 1, Phase 2
20 Prenatal Screening For Smith-Lemli-Opitz Syndrome Completed NCT00070850 Phase 2
21 Simvastatin Therapy in Smith-Lemli-Opitz Syndrome Completed NCT00064792 Phase 2
22 Furlow Palatoplasty With Tensor Tenopexy Recruiting NCT01535131 Phase 2
23 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2
24 Ambrisentan in Single Ventricle Recruiting NCT02080637 Phase 2
25 IV Acetaminophen in Children Undergoing Palatoplasty Withdrawn NCT01760330 Phase 2
26 The Use of Self Inflating Tissue Expanders In The Treatment Of Alveolar Cleft Active, not recruiting NCT03010345 Phase 1
27 An Investigation for the Optimal Timing of a Cleft Palate Repair Unknown status NCT00779961 Early Phase 1
28 FaceBase Biorepository Unknown status NCT01252264
29 Oxygen Insuflation and ArterialDesaturation During Tracheal Intubation in Children Unknown status NCT01664234
30 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714
31 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Unknown status NCT01932164
32 SLOS: The Effect of Simvastatin in Patients Receiving Cholesterol Supplementation Unknown status NCT01434745
33 Sterol and Isoprenoid Disease Research Consortium: Smith-Lemli-Opitz Syndrome Unknown status NCT01356420
34 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998
35 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623
36 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
37 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
38 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726
39 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
40 Sleep and Behavior in Children With Cleft Palate Completed NCT01046591
41 Retrospective Study on the Outcome of Cleft Palate Repair: Comparing US Surgical and Ethicon Suture Materials Completed NCT00584272
42 Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair Completed NCT01500109
43 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
44 Using of Acellular Dermal Matrix in Cleft Palatal Fistula and Compare With Use of Conchal Cartolage Completed NCT03170505
45 Postoperative Complications After Cleft Palate Closure in Patients With Pierre Robin Sequence: Operative Considerations Completed NCT02658318
46 Pilot Study Evaluating Characteristic Closure Patterns of the Normal Velopharyngeal Portal Completed NCT00773994
47 Tympanometric Analysis in Cleft Palate Completed NCT01820689
48 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
49 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509
50 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977

Search NIH Clinical Center for Cleft Palate, Isolated

Cochrane evidence based reviews: cleft palate

Genetic Tests for Cleft Palate, Isolated

Genetic tests related to Cleft Palate, Isolated:

id Genetic test Affiliating Genes
1 Cleft Palate, Isolated 29 24
2 Cleft Palate 29

Anatomical Context for Cleft Palate, Isolated

Publications for Cleft Palate, Isolated

Variations for Cleft Palate, Isolated

ClinVar genetic disease variations for Cleft Palate, Isolated:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 IRF6 NM_006147.3(IRF6): c.16C> T (p.Arg6Cys) single nucleotide variant Pathogenic/Likely pathogenic rs28942094 GRCh37 Chromosome 1, 209974743: 209974743
2 FLNA NM_001110556.1(FLNA): c.620C> T (p.Pro207Leu) single nucleotide variant Pathogenic rs28935469 GRCh37 Chromosome X, 153596212: 153596212

Copy number variations for Cleft Palate, Isolated from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 43412 10 46400346 51237832 Deletion cleft palate
2 161497 22 19062809 19791607 Deletion cleft palate
3 161606 22 19412033 19790830 Duplication cleft palate

Expression for Cleft Palate, Isolated

Search GEO for disease gene expression data for Cleft Palate, Isolated.

Pathways for Cleft Palate, Isolated

GO Terms for Cleft Palate, Isolated

Cellular components related to Cleft Palate, Isolated according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BMP4 COL11A1 COL11A2 COL2A1 FGFR1 FGFR2
2 endoplasmic reticulum lumen GO:0005788 9.56 BMP4 COL11A1 COL11A2 COL2A1
3 collagen trimer GO:0005581 9.33 COL11A1 COL11A2 COL2A1
4 collagen type XI trimer GO:0005592 8.62 COL11A1 COL11A2

Biological processes related to Cleft Palate, Isolated according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.96 BMP4 FGFR1 FGFR2 FOXC2 FOXE1 MSX1
2 lung development GO:0030324 9.92 BMP4 FGFR1 FGFR2
3 wound healing GO:0042060 9.91 FGFR2 TGFA TGFB3
4 BMP signaling pathway GO:0030509 9.91 BMP4 MSX1 TGFB3
5 fibroblast growth factor receptor signaling pathway GO:0008543 9.9 FGFR1 FGFR2 UBB
6 sensory perception of sound GO:0007605 9.89 COL11A1 COL11A2 COL2A1 FGFR1 GABRB3
7 collagen catabolic process GO:0030574 9.87 COL11A1 COL11A2 COL2A1
8 positive regulation of epithelial cell proliferation GO:0050679 9.87 BMP4 FGFR2 TGFA
9 odontogenesis of dentin-containing tooth GO:0042475 9.86 BMP4 MSX1 TP63
10 bone development GO:0060348 9.85 BMP4 COL2A1 FGFR2
11 positive regulation of cell division GO:0051781 9.85 FGFR2 TGFA TGFB3
12 inner ear morphogenesis GO:0042472 9.85 COL11A1 COL2A1 FGFR1 FGFR2
13 embryonic limb morphogenesis GO:0030326 9.84 BMP4 FGFR1 MSX1 TP63
14 embryonic skeletal system morphogenesis GO:0048704 9.83 BMP4 COL11A1 FOXC2 SATB2
15 midbrain development GO:0030901 9.81 FGFR1 FGFR2 MSX1
16 heart morphogenesis GO:0003007 9.81 COL11A1 COL2A1 FOXC2 MSX1
17 lung alveolus development GO:0048286 9.8 BMP4 FGFR2 TGFB3
18 embryonic cranial skeleton morphogenesis GO:0048701 9.8 BMP4 FGFR2 FOXC2
19 ureteric bud development GO:0001657 9.78 BMP4 FGFR1 FGFR2 FOXC2
20 positive regulation of mesenchymal cell proliferation GO:0002053 9.77 FGFR1 FGFR2 TP63
21 hair follicle morphogenesis GO:0031069 9.77 FGFR2 FOXE1 TP63
22 ossification GO:0001503 9.77 BMP4 COL11A1 COL11A2 COL2A1 FOXC2
23 chondrocyte differentiation GO:0002062 9.76 BMP4 COL11A2 COL2A1 FGFR1
24 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.74 BMP4 MSX1
25 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.74 COL11A1 FGFR2 FOXC2
26 keratinocyte proliferation GO:0043616 9.73 IRF6 TP63
27 branching involved in salivary gland morphogenesis GO:0060445 9.73 FGFR1 FGFR2
28 mesodermal cell differentiation GO:0048333 9.73 BMP4 FGFR2
29 positive regulation of SMAD protein import into nucleus GO:0060391 9.73 BMP4 TGFB3
30 collagen fibril organization GO:0030199 9.73 COL11A1 COL11A2 COL2A1 FOXC2
31 organ induction GO:0001759 9.72 BMP4 FGFR1
32 smooth muscle tissue development GO:0048745 9.72 BMP4 TP63
33 embryonic skeletal joint morphogenesis GO:0060272 9.72 BMP4 COL2A1
34 skeletal system morphogenesis GO:0048705 9.72 COL11A1 COL11A2 COL2A1 FGFR1 FGFR2
35 salivary gland morphogenesis GO:0007435 9.71 FGFR1 TGFB3
36 limb bud formation GO:0060174 9.71 COL2A1 FGFR2
37 lung-associated mesenchyme development GO:0060484 9.71 FGFR1 FGFR2
38 mesenchymal cell differentiation GO:0048762 9.71 FGFR1 FGFR2
39 membranous septum morphogenesis GO:0003149 9.71 BMP4 FGFR2
40 odontogenesis GO:0042476 9.71 BMP4 FGFR2 MSX1 TGFB3
41 positive regulation of phospholipase activity GO:0010518 9.69 FGFR1 FGFR2
42 proteoglycan metabolic process GO:0006029 9.69 COL11A1 COL2A1
43 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.68 BMP4 FGFR2
44 bud elongation involved in lung branching GO:0060449 9.68 BMP4 FGFR2
45 BMP signaling pathway involved in heart development GO:0061312 9.68 BMP4 MSX1
46 regulation of smooth muscle cell differentiation GO:0051150 9.67 BMP4 FGFR2
47 branching involved in prostate gland morphogenesis GO:0060442 9.67 BMP4 FGFR2
48 embryonic organ morphogenesis GO:0048562 9.66 FGFR2 FOXE1
49 prostate gland morphogenesis GO:0060512 9.66 BMP4 FGFR2
50 soft palate development GO:0060023 9.65 COL11A2 FOXE1

Molecular functions related to Cleft Palate, Isolated according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.33 COL11A1 COL11A2 COL2A1
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL11A2 COL2A1
3 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR1 FGFR2

Sources for Cleft Palate, Isolated

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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