Aliases & Classifications for Clivus Chordoma

MalaCards integrated aliases for Clivus Chordoma:

Name: Clivus Chordoma 12 14
Chordoma of Clivus 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6312
NCIt 46 C5412
SNOMED-CT 64 446939001
UMLS 69 C1333071

Summaries for Clivus Chordoma

Disease Ontology : 12 A chordoma of skull base that is located in the clivus.

MalaCards based summary : Clivus Chordoma, also known as chordoma of clivus, is related to chordoma and spastic paraplegia 25, autosomal recessive, and has symptoms including headache An important gene associated with Clivus Chordoma is HOXA10 (Homeobox A10), and among its related pathways/superpathways are Akt Signaling and CREB Pathway. Affiliated tissues include bone, hypothalamus and brain, and related phenotypes are nervous system and skeleton

Related Diseases for Clivus Chordoma

Graphical network of the top 20 diseases related to Clivus Chordoma:



Diseases related to Clivus Chordoma

Symptoms & Phenotypes for Clivus Chordoma

UMLS symptoms related to Clivus Chordoma:


headache

MGI Mouse Phenotypes related to Clivus Chordoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.43 CXCL12 FGF13 FGF2 HOXA10 HRAS PTEN
2 skeleton MP:0005390 9.1 FGF2 HOXA10 HOXA7 HOXA9 HRAS PTEN

Drugs & Therapeutics for Clivus Chordoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors Recruiting NCT00931931 Phase 1

Search NIH Clinical Center for Clivus Chordoma

Genetic Tests for Clivus Chordoma

Anatomical Context for Clivus Chordoma

MalaCards organs/tissues related to Clivus Chordoma:

38
Bone, Hypothalamus, Brain, Cortex

Publications for Clivus Chordoma

Articles related to Clivus Chordoma:

(show all 27)
# Title Authors Year
1
An unusual case of acquired pedophilic behavior following compression of orbitofrontal cortex and hypothalamus by a Clivus Chordoma. ( 27159984 )
2016
2
Sustained response of a clivus chordoma to erlotinib after imatinib failure. ( 25762924 )
2015
3
Experimental Study on Differences in Clivus Chordoma Bone Invasion: An iTRAQ-Based Quantitative Proteomic Analysis. ( 25793716 )
2015
4
On "clivus chordoma: is it enough to image the primary site?" (skull base 2010;20:111-113). ( 22470272 )
2011
5
The transnasal transclival approach for clivus chordoma. ( 21302187 )
2010
6
Clivus chordoma: is it enough to image the primary site? ( 20808536 )
2010
7
Clivus chordoma in continuity with a large pontine cyst. ( 19721775 )
2009
8
Infantile clivus chordoma without clivus involvement: case report and review of the literature. ( 16565853 )
2006
9
Recurrent and metastatic clivus chordoma: systemic palliative therapy retards disease progression. ( 16222158 )
2005
10
Clivus chordoma associated with a pontine arachnoid cyst. ( 15992705 )
2005
11
Candida albicans granuloma imitate clivus chordoma. ( 12111509 )
2002
12
Does the tuberous sclerosis complex include clivus chordoma? A case report. ( 11271387 )
2001
13
Herpes simplex meningitis after surgical removal of a clivus chordoma. ( 9177973 )
1997
14
Clivus chordoma. ( 9322379 )
1997
15
Congenital clivus chordoma. ( 8517337 )
1993
16
Proton radiation therapy for clivus chordoma--case report. ( 7683125 )
1993
17
Clivus chordoma: a report of 12 recent cases and review of the literature. ( 17170837 )
1991
18
Transoral transpalatal removal of a giant premesencephalic clivus chordoma. ( 1776517 )
1991
19
Surgical access for clivus chordoma. The University of California, San Francisco, experience. ( 2917064 )
1989
20
Clivus chordoma in childhood. ( 3589943 )
1987
21
Clivus chordoma in a 9-year-old child: case report and review of the literature. ( 3152925 )
1987
22
Clivus chordoma in a child with tuberous sclerosis: CT and MR demonstration. ( 3805419 )
1987
23
Bilateral abducens nerve palsies from clivus chordoma. ( 7258964 )
1981
24
Clivus chordoma with distinct vascularity demonstrated by angiography. ( 896037 )
1977
25
Clivus chordoma with unusual bone sclerosis and brainstem invasion. A case report with review of the radiology of cranial chordomas. ( 1212128 )
1975
26
Transcervical removal of a clivus chordoma in a 2-year-old child. Reversal of quadriplegia and bulbar paralysis. ( 5531855 )
1970
27
A transcervical transclival approach to the ventral surface of the brain stem for removal of a clivus chordoma. ( 5295919 )
1966

Variations for Clivus Chordoma

Expression for Clivus Chordoma

Search GEO for disease gene expression data for Clivus Chordoma.

Pathways for Clivus Chordoma

Pathways related to Clivus Chordoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 CXCL12 FGF13 FGF2 HRAS PTEN
2
Show member pathways
12.74 CXCL12 FGF13 FGF2 HRAS PTEN
3
Show member pathways
12.66 CXCL12 FGF13 FGF2 HRAS
4
Show member pathways
12.42 CXCL12 FGF13 FGF2 HRAS PTEN
5 12.28 FGF13 FGF2 HRAS
6
Show member pathways
12.22 FGF2 HRAS PTEN
7 12.18 CXCL12 FGF2 HRAS PTEN
8
Show member pathways
12.1 FGF13 FGF2 HRAS
9
Show member pathways
12.01 FGF13 FGF2 HRAS
10
Show member pathways
11.91 CXCL12 FGF13 FGF2 HRAS PTEN
11
Show member pathways
11.75 FGF2 HRAS PTEN
12 11.39 HRAS PTEN
13 11.37 HRAS PTEN
14 11.27 HRAS PTEN
15 11.12 FGF2 HRAS
16 10.92 CXCL12 FGF2
17 10.88 HRAS PTEN

GO Terms for Clivus Chordoma

Biological processes related to Clivus Chordoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.63 FGF13 FGF2 HRAS
2 angiogenesis GO:0001525 9.61 FGF2 HOXA7 PTEN
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.58 FGF2 HRAS PTEN
4 positive regulation of cell proliferation GO:0008284 9.56 CXCL12 FGF2 HRAS PTEN
5 chemotaxis GO:0006935 9.5 CXCL12 FGF2 HRAS
6 positive regulation of MAP kinase activity GO:0043406 9.49 FGF2 HRAS
7 positive chemotaxis GO:0050918 9.48 CXCL12 FGF2
8 proximal/distal pattern formation GO:0009954 9.37 HOXA10 HOXA9
9 positive regulation of transcription by RNA polymerase II GO:0045944 9.35 FGF2 HOXA10 HOXA7 HOXA9 HRAS
10 uterus development GO:0060065 9.16 HOXA10 HOXA9
11 anterior/posterior pattern specification GO:0009952 8.8 HOXA10 HOXA7 HOXA9

Molecular functions related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 8.96 CXCL12 FGF2
2 growth factor activity GO:0008083 8.8 CXCL12 FGF13 FGF2

Sources for Clivus Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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