MCID: CLC003
MIFTS: 32

Cloacogenic Carcinoma

Categories: Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Cloacogenic Carcinoma

MalaCards integrated aliases for Cloacogenic Carcinoma:

Name: Cloacogenic Carcinoma 12 14 69
Cloacogenic Anal Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7173
MeSH 42 C563020
NCIt 47 C8255
SNOMED-CT 64 84570003
UMLS 69 C0334273

Summaries for Cloacogenic Carcinoma

MalaCards based summary : Cloacogenic Carcinoma, also known as cloacogenic anal carcinoma, is related to rectal cloacogenic carcinoma and photoallergic dermatitis. An important gene associated with Cloacogenic Carcinoma is KERA (Keratocan), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Cisplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include colon and prostate, and related phenotype is craniofacial.

Related Diseases for Cloacogenic Carcinoma

Diseases related to Cloacogenic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 rectal cloacogenic carcinoma 11.9
2 photoallergic dermatitis 10.7 PTH PTHLH
3 pineal gland cancer 10.7 PTH PTHLH
4 osteoblastoma 10.7 ENO2 KRT5
5 macular retinal edema 10.7 POMC SOX2
6 teratocarcinoma 10.7 PTH PTHLH
7 bronchus adenoma 10.7 ENO2 KRT5
8 cutis laxa 10.7 POMC PTH
9 skin papilloma 10.7 ENO2 KRT5
10 cysticercosis 10.6 KRT4 KRT5
11 lymphoma, gastric non hodgkins type 10.6 ENO2 POMC
12 guillain-barre syndrome 10.6 POMC PTH
13 ophn1 syndrome 10.6 PTH PTHLH
14 fallopian tube squamous cell carcinoma 10.6 KRT5 PTPRC
15 lipid-cell variant infiltrating bladder urothelial carcinoma 10.6 CEACAM5 KRT5
16 intellectual disability-polydactyly-uncombable hair syndrome 10.5 ENO2 PTPRC
17 mucoepidermoid esophageal carcinoma 10.5 CEACAM5 KRT5
18 cystic kidney disease 10.5 ENO2 PTHLH
19 uremia 10.5 HBA1 SOX2
20 lung benign neoplasm 10.5 ENO2 PTPRC
21 ovarian large-cell neuroendocrine carcinoma 10.5 ENO2 KRT5 PTHLH
22 teeth hard tissue disease 10.4 HBA1 PTPRC
23 coronary aneurysm 10.4 HBA1 PTPRC
24 nodular medulloblastoma 10.4 CEACAM5 ENO2
25 salivary gland adenoid cystic carcinoma 10.4 HBA1 PTPRC
26 theileriasis 10.4 B2M CD27
27 generalized anxiety disorder 10.4 CEACAM5 POMC
28 denture stomatitis 10.4 B2M POMC
29 pigmented villonodular synovitis 10.4 CEACAM5 PTHLH
30 brain stem infarction 10.4 ENO2 PTPRC
31 tibial nerve palsy 10.4 B2M POMC
32 breast mucoepidermoid carcinoma 10.4 B2M PTH
33 epiphora due to excess lacrimation 10.4 CEACAM5 SOX2
34 thymus small cell carcinoma 10.4 ENO2 PTPRC
35 childhood spinal cord tumor 10.4 KRT5 PTPRC
36 hypochondrogenesis 10.4 CALCA PTH
37 pneumonia 10.3 ENO2 KRT5
38 neuropathy, hereditary thermosensitive 10.3 CALCA NPS
39 penis squamous cell carcinoma 10.3 CEACAM5 KRT5 PTHLH
40 cribriform carcinoma 10.3 ENO2 KRT5 PTPRC
41 mixed cell type adenoma of parathyroid 10.3 CALCA PTH
42 ovarian wilms' cancer 10.3 CEACAM5 PTPRC
43 pemphigus foliaceus 10.3 CALCA ENO2
44 lacrimal gland mucoepidermoid carcinoma 10.3 CEACAM5 KRT5 PTHLH
45 cervical keratinizing squamous cell carcinoma 10.3 CALCA ENO2
46 seminal vesicle chronic gonorrhea 10.3 CALCA POMC
47 trachea adenoid cystic carcinoma 10.3 B2M CEACAM5
48 connective tissue benign neoplasm 10.3 ENO2 HBA1 KRT5
49 sphenoid sinus squamous cell carcinoma 10.3 CEACAM5 ENO2
50 encephalitozoonosis 10.3 ENO2 HBA1 PTHLH

Graphical network of the top 20 diseases related to Cloacogenic Carcinoma:



Diseases related to Cloacogenic Carcinoma

Symptoms & Phenotypes for Cloacogenic Carcinoma

MGI Mouse Phenotypes related to Cloacogenic Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.1 ENO2 KRT4 KRT5 PTH PTHLH SOX2

Drugs & Therapeutics for Cloacogenic Carcinoma

Drugs for Cloacogenic Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
2
Fluorouracil Approved Phase 3,Phase 2 51-21-8 3385
3 Antimetabolites Phase 3,Phase 2
4 Antimetabolites, Antineoplastic Phase 3,Phase 2
5 Immunosuppressive Agents Phase 3,Phase 2
6 Alkylating Agents Phase 3,Phase 2
7 Anti-Bacterial Agents Phase 3,Phase 2
8 Antibiotics, Antitubercular Phase 3,Phase 2
9 Mitomycins Phase 3,Phase 2
10 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
11
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
12
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
13
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
14
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
15
nivolumab Approved Phase 2 946414-94-4
16 Albumin-Bound Paclitaxel Phase 2
17 Antimitotic Agents Phase 2
18 Antineoplastic Agents, Phytogenic Phase 2
19 Antibodies Phase 2
20 Antibodies, Monoclonal Phase 2
21 Immunoglobulins Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
4 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
5 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
6 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
7 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil
8 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Not yet recruiting NCT03233711 Phase 2

Search NIH Clinical Center for Cloacogenic Carcinoma

Genetic Tests for Cloacogenic Carcinoma

Anatomical Context for Cloacogenic Carcinoma

MalaCards organs/tissues related to Cloacogenic Carcinoma:

39
Colon, Prostate

Publications for Cloacogenic Carcinoma

Articles related to Cloacogenic Carcinoma:

(show all 50)
id Title Authors Year
1
Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. ( 24584270 )
2014
2
What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone? ( 21510286 )
2011
3
Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center. ( 20689291 )
2010
4
Basaloid (Cloacogenic) Carcinoma Mimicking Intraabdominal Abscess: Report of a Case and Review of the Literature. ( 21103283 )
2009
5
Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. ( 20084726 )
2007
6
An unusual location of cloacogenic carcinoma. ( 10096758 )
1998
7
Inflammatory cutaneous metastases from cloacogenic carcinoma of the anus. ( 7633821 )
1995
8
Mixed cloacogenic carcinoma of male urethra. ( 1737633 )
1992
9
Cloacogenic carcinoma of the anal canal and associated viral lesions. An in situ hybridization study for human papilloma virus. ( 1657356 )
1991
10
Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium. ( 1709765 )
1991
11
Transitional cloacogenic carcinoma of the female urethra treated with external irradiation and afterloading with cobalt-60. ( 2024362 )
1991
12
Multicentric cloacogenic carcinoma: report of a case with anogenital pruritus at presentation. ( 2229531 )
1990
13
Neurologic complications of cloacogenic carcinoma. ( 2389732 )
1990
14
Prostatic acid phosphatase in cloacogenic carcinoma. ( 2223150 )
1990
15
Small cell neuroendocrine carcinoma of the colon and rectum: clinical, histologic, and ultrastructural study and immunohistochemical comparison with cloacogenic carcinoma. ( 2434408 )
1987
16
Simultaneous cloacogenic carcinoma in dizygotic twins. ( 3815298 )
1987
17
Regression of pulmonary metastases from cloacogenic carcinoma after cis-platinum/5-fluorouracil treatment. ( 6539351 )
1984
18
Basal cell carcinoma of the anus: clinical and pathological distinction from cloacogenic carcinoma. ( 6501831 )
1984
19
An unusual type of cytokeratin filament in cells of a human cloacogenic carcinoma derived from the anorectal transition zone. ( 6179812 )
1982
20
Cloacogenic carcinoma: a study of six cases and review of literature. ( 7081171 )
1982
21
Perianal Paget's disease associated with cloacogenic carcinoma: report of a case. ( 6271515 )
1981
22
Anal cloacogenic carcinoma: classification and clinical behavior. ( 7213001 )
1981
23
Cloacogenic carcinoma. ( 7338617 )
1981
24
Response of metastatic cloacogenic carcinoma to treatment with semustine. ( 7306917 )
1981
25
Results of treatment in transitional cloacogenic carcinoma. ( 7397647 )
1980
26
Ectopic Cushing's syndrome in cloacogenic carcinoma of the anal canal: a case demonstrating APUD characteristics. ( 6113712 )
1980
27
Cloacogenic carcinoma of the anus. ( 7392643 )
1980
28
Cloacogenic carcinoma of the vagina. ( 761463 )
1979
29
Transitional cloacogenic carcinoma of the anus and rectum: report of three cases. ( 448760 )
1979
30
Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. ( 527449 )
1979
31
Colonoscopic inversion in the diagnosis of cloacogenic carcinoma. ( 510887 )
1979
32
Cloacogenic carcinoma. ( 666378 )
1978
33
Histogenesis of cloacogenic carcinoma. Fine structure of anal transitional epithelium and cloacogenic carcinoma. ( 711233 )
1978
34
Metastatic cloacogenic carcinoma of the anus: sequential responses to adriamycin and cis-dichlorodiammineplatinum(II). ( 627000 )
1978
35
Transitional cloacogenic carcinoma of the anus. ( 832555 )
1977
36
Basosquamous (transitional cloacogenic) carcinoma of the sigmoid colon. ( 198090 )
1977
37
Cloacogenic carcinoma. ( 966304 )
1976
38
Transitional-cell cloacogenic carcinoma of the anal canal: Case report. ( 1159269 )
1975
39
Value of lymphography in detecting metastatic cloacogenic carcinoma. ( 4842493 )
1974
40
Transitional cloacogenic carcinoma of the urethra. ( 4736268 )
1973
41
Radiation therapy in transitional cloacogenic carcinoma of the anorectal junction. ( 4718581 )
1973
42
Cloacogenic carcinoma of the anorectal junction. Roentgenologic diagnosis. ( 5037801 )
1972
43
Cloacogenic carcinoma of the anal canal. ( 5013777 )
1972
44
Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum: report of seven cases. ( 5172130 )
1971
45
The basal cell nature of the so-called transitional cloacogenic carcinoma of anus as revealed by electron microscopy. ( 5796777 )
1969
46
Cloacogenic carcinoma. ( 5811555 )
1969
47
Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, MA1llerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma. ( 4289492 )
1967
48
Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred seventy-three cases. ( 6058180 )
1967
49
Cloacogenic carcinoma of the anorectal junction. ( 5853526 )
1965
50
Transitional cell carcinoma of the rectum (cloacogenic carcinoma). Report of a case. ( 5839639 )
1965

Variations for Cloacogenic Carcinoma

Expression for Cloacogenic Carcinoma

Search GEO for disease gene expression data for Cloacogenic Carcinoma.

Pathways for Cloacogenic Carcinoma

Pathways related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.19 CALCA NPS POMC PTH PTHLH

GO Terms for Cloacogenic Carcinoma

Cellular components related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 B2M CALCA ENO2 F12 HBA1 KERA
2 extracellular region GO:0005576 9.36 B2M CALCA CD27 CEACAM5 F12 HBA1

Biological processes related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.67 CALCA POMC PTH PTHLH
2 neuropeptide signaling pathway GO:0007218 9.43 CALCA NPS POMC
3 negative regulation of chondrocyte differentiation GO:0032331 9.4 PTH PTHLH
4 positive regulation of cAMP biosynthetic process GO:0030819 9.33 CALCA PTH PTHLH
5 positive regulation of ossification GO:0045778 9.32 CALCA PTH
6 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.13 CALCA PTH PTHLH
7 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.96 PTH PTHLH
2 hormone activity GO:0005179 8.92 CALCA POMC PTH PTHLH

Sources for Cloacogenic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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