MCID: CLC003
MIFTS: 35

Cloacogenic Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cloacogenic Carcinoma

MalaCards integrated aliases for Cloacogenic Carcinoma:

Name: Cloacogenic Carcinoma 12 14 69
Cloacogenic Anal Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7173
MeSH 41 C563020
NCIt 46 C8255
SNOMED-CT 64 84570003
UMLS 69 C0334273

Summaries for Cloacogenic Carcinoma

MalaCards based summary : Cloacogenic Carcinoma, also known as cloacogenic anal carcinoma, is related to hypercalcemia, infantile, 1 and rectal cloacogenic carcinoma. An important gene associated with Cloacogenic Carcinoma is KERA (Keratocan), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Cisplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include colon and prostate, and related phenotype is craniofacial.

Related Diseases for Cloacogenic Carcinoma

Diseases related to Cloacogenic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 hypercalcemia, infantile, 1 30.1 CALCA PTH PTHLH
2 rectal cloacogenic carcinoma 12.1
3 extraskeletal chondroma 10.5 PTH PTHLH
4 sclerosing hepatic carcinoma 10.5 PTH PTHLH
5 central nervous system germ cell tumor 10.5 POMC SOX2
6 invasive malignant thymoma 10.5 PTH PTHLH
7 sensory organ benign neoplasm 10.5 ENO2 KRT5
8 middle ear adenoma 10.5 ENO2 KRT5
9 hymenolepiasis 10.4 KRT4 KRT5
10 scleredema adultorum 10.4 POMC PTH
11 thyroid crisis 10.4 POMC PTH
12 lymphocytic hypophysitis 10.4 ENO2 POMC
13 sarcomatoid squamous cell skin carcinoma 10.4 KRT5 PTPRC
14 esophageal adenosquamous carcinoma 10.4 CEACAM5 KRT5
15 primitive neuroectodermal tumor of the cervix uteri 10.4 ENO2 PTPRC
16 malignant spiradenoma 10.3 CEACAM5 KRT5
17 oncogenic osteomalacia 10.3 PTH PTHLH
18 pleomorphic adenoma carcinoma 10.3 ENO2 PTHLH
19 bile duct mucoepidermoid carcinoma 10.3 CEACAM5 KRT5
20 gastric squamous cell carcinoma 10.3 ENO2 KRT5
21 venous hemangioma 10.3 HBA1 SOX2
22 kidney rhabdoid cancer 10.3 ENO2 PTPRC
23 epidural neoplasm 10.3 CD27 KRT5 PTPRC
24 large cell carcinoma 10.3 ENO2 KRT5 PTHLH
25 conventional fibrosarcoma 10.3 ENO2 PTPRC
26 liver sarcoma 10.3 CEACAM5 PTHLH
27 melanotic medulloblastoma 10.3 CEACAM5 ENO2
28 glomeruloid hemangioma 10.3 HBA1 PTPRC
29 tuberculous empyema 10.3 CEACAM5 POMC
30 tibial neuropathy 10.3 B2M POMC
31 orbital cyst 10.3 CEACAM5 SOX2
32 brain sarcoma 10.3 HBA1 PTPRC
33 tarsal tunnel syndrome 10.3 B2M POMC
34 endometrial small cell carcinoma 10.3 ENO2 PTPRC
35 extraosseous osteosarcoma 10.3 HBA1 PTPRC
36 uremic neuropathy 10.2 B2M PTH
37 solitary osseous plasmacytoma 10.2 B2M CD27
38 acquired metabolic disease 10.2 POMC PTH PTHLH
39 fibrogenesis imperfecta ossium 10.2 CALCA PTH
40 reflex sympathetic dystrophy 10.2 CALCA NPS
41 chorioangioma 10.2 HBA1 PTHLH
42 breast squamous cell carcinoma 10.2 CEACAM5 KRT5 PTHLH
43 ovarian lymphoma 10.2 CEACAM5 PTPRC
44 breast metaplastic carcinoma 10.2 CEACAM5 KRT5 PTHLH
45 pancreatic somatostatinoma 10.2 CALCA ENO2
46 rete testis adenocarcinoma 10.2 CEACAM5 ENO2
47 duodenal somatostatinoma 10.2 CALCA ENO2
48 secondary hypertrophic osteoarthropathy 10.2 CALCA POMC
49 integumentary system benign neoplasm 10.2 ENO2 HBA1 KRT5
50 pericardial tuberculosis 10.1 CEACAM5 POMC

Graphical network of the top 20 diseases related to Cloacogenic Carcinoma:



Diseases related to Cloacogenic Carcinoma

Symptoms & Phenotypes for Cloacogenic Carcinoma

MGI Mouse Phenotypes related to Cloacogenic Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.1 ENO2 KRT4 KRT5 PTH PTHLH SOX2

Drugs & Therapeutics for Cloacogenic Carcinoma

Drugs for Cloacogenic Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
2
Fluorouracil Approved Phase 3,Phase 2 51-21-8 3385
3 Immunosuppressive Agents Phase 3,Phase 2
4 Antimetabolites Phase 3,Phase 2
5 Antimetabolites, Antineoplastic Phase 3,Phase 2
6 Alkylating Agents Phase 3,Phase 2
7 Mitomycins Phase 3,Phase 2
8 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
9 Anti-Bacterial Agents Phase 3,Phase 2
10 Antibiotics, Antitubercular Phase 3,Phase 2
11
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
12
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
13
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
14
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
15
nivolumab Approved Phase 2 946414-94-4
16 Albumin-Bound Paclitaxel Phase 2
17 Antimitotic Agents Phase 2
18 Antineoplastic Agents, Phytogenic Phase 2
19 Antibodies, Monoclonal Phase 2
20 Immunoglobulins Phase 2
21 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
4 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
5 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
6 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
7 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil
8 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Not yet recruiting NCT03233711 Phase 2

Search NIH Clinical Center for Cloacogenic Carcinoma

Genetic Tests for Cloacogenic Carcinoma

Anatomical Context for Cloacogenic Carcinoma

MalaCards organs/tissues related to Cloacogenic Carcinoma:

38
Colon, Prostate

Publications for Cloacogenic Carcinoma

Articles related to Cloacogenic Carcinoma:

(show all 50)
# Title Authors Year
1
Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. ( 24584270 )
2014
2
What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone? ( 21510286 )
2011
3
Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center. ( 20689291 )
2010
4
Basaloid (Cloacogenic) Carcinoma Mimicking Intraabdominal Abscess: Report of a Case and Review of the Literature. ( 21103283 )
2009
5
Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. ( 20084726 )
2007
6
An unusual location of cloacogenic carcinoma. ( 10096758 )
1998
7
Inflammatory cutaneous metastases from cloacogenic carcinoma of the anus. ( 7633821 )
1995
8
Mixed cloacogenic carcinoma of male urethra. ( 1737633 )
1992
9
Cloacogenic carcinoma of the anal canal and associated viral lesions. An in situ hybridization study for human papilloma virus. ( 1657356 )
1991
10
Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium. ( 1709765 )
1991
11
Transitional cloacogenic carcinoma of the female urethra treated with external irradiation and afterloading with cobalt-60. ( 2024362 )
1991
12
Prostatic acid phosphatase in cloacogenic carcinoma. ( 2223150 )
1990
13
Multicentric cloacogenic carcinoma: report of a case with anogenital pruritus at presentation. ( 2229531 )
1990
14
Neurologic complications of cloacogenic carcinoma. ( 2389732 )
1990
15
Small cell neuroendocrine carcinoma of the colon and rectum: clinical, histologic, and ultrastructural study and immunohistochemical comparison with cloacogenic carcinoma. ( 2434408 )
1987
16
Simultaneous cloacogenic carcinoma in dizygotic twins. ( 3815298 )
1987
17
Basal cell carcinoma of the anus: clinical and pathological distinction from cloacogenic carcinoma. ( 6501831 )
1984
18
Regression of pulmonary metastases from cloacogenic carcinoma after cis-platinum/5-fluorouracil treatment. ( 6539351 )
1984
19
Cloacogenic carcinoma: a study of six cases and review of literature. ( 7081171 )
1982
20
An unusual type of cytokeratin filament in cells of a human cloacogenic carcinoma derived from the anorectal transition zone. ( 6179812 )
1982
21
Cloacogenic carcinoma. ( 7338617 )
1981
22
Anal cloacogenic carcinoma: classification and clinical behavior. ( 7213001 )
1981
23
Perianal Paget's disease associated with cloacogenic carcinoma: report of a case. ( 6271515 )
1981
24
Response of metastatic cloacogenic carcinoma to treatment with semustine. ( 7306917 )
1981
25
Cloacogenic carcinoma of the anus. ( 7392643 )
1980
26
Ectopic Cushing's syndrome in cloacogenic carcinoma of the anal canal: a case demonstrating APUD characteristics. ( 6113712 )
1980
27
Results of treatment in transitional cloacogenic carcinoma. ( 7397647 )
1980
28
Colonoscopic inversion in the diagnosis of cloacogenic carcinoma. ( 510887 )
1979
29
Cloacogenic carcinoma of the vagina. ( 761463 )
1979
30
Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. ( 527449 )
1979
31
Transitional cloacogenic carcinoma of the anus and rectum: report of three cases. ( 448760 )
1979
32
Histogenesis of cloacogenic carcinoma. Fine structure of anal transitional epithelium and cloacogenic carcinoma. ( 711233 )
1978
33
Cloacogenic carcinoma. ( 666378 )
1978
34
Metastatic cloacogenic carcinoma of the anus: sequential responses to adriamycin and cis-dichlorodiammineplatinum(II). ( 627000 )
1978
35
Basosquamous (transitional cloacogenic) carcinoma of the sigmoid colon. ( 198090 )
1977
36
Transitional cloacogenic carcinoma of the anus. ( 832555 )
1977
37
Cloacogenic carcinoma. ( 966304 )
1976
38
Transitional-cell cloacogenic carcinoma of the anal canal: Case report. ( 1159269 )
1975
39
Value of lymphography in detecting metastatic cloacogenic carcinoma. ( 4842493 )
1974
40
Transitional cloacogenic carcinoma of the urethra. ( 4736268 )
1973
41
Radiation therapy in transitional cloacogenic carcinoma of the anorectal junction. ( 4718581 )
1973
42
Cloacogenic carcinoma of the anal canal. ( 5013777 )
1972
43
Cloacogenic carcinoma of the anorectal junction. Roentgenologic diagnosis. ( 5037801 )
1972
44
Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum: report of seven cases. ( 5172130 )
1971
45
The basal cell nature of the so-called transitional cloacogenic carcinoma of anus as revealed by electron microscopy. ( 5796777 )
1969
46
Cloacogenic carcinoma. ( 5811555 )
1969
47
Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred seventy-three cases. ( 6058180 )
1967
48
Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, MA1llerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma. ( 4289492 )
1967
49
Cloacogenic carcinoma of the anorectal junction. ( 5853526 )
1965
50
Transitional cell carcinoma of the rectum (cloacogenic carcinoma). Report of a case. ( 5839639 )
1965

Variations for Cloacogenic Carcinoma

Expression for Cloacogenic Carcinoma

Search GEO for disease gene expression data for Cloacogenic Carcinoma.

Pathways for Cloacogenic Carcinoma

Pathways related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.19 CALCA NPS POMC PTH PTHLH

GO Terms for Cloacogenic Carcinoma

Cellular components related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 B2M CALCA ENO2 F12 HBA1 KERA
2 extracellular region GO:0005576 9.36 B2M CALCA CD27 CEACAM5 F12 HBA1

Biological processes related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.62 CALCA POMC PTH PTHLH
2 neuropeptide signaling pathway GO:0007218 9.43 CALCA NPS POMC
3 negative regulation of chondrocyte differentiation GO:0032331 9.4 PTH PTHLH
4 positive regulation of ossification GO:0045778 9.37 CALCA PTH
5 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.33 CALCA PTH PTHLH
6 positive regulation of cAMP biosynthetic process GO:0030819 9.13 CALCA PTH PTHLH
7 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.96 PTH PTHLH
2 hormone activity GO:0005179 8.92 CALCA POMC PTH PTHLH

Sources for Cloacogenic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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