Clostridium Difficile malady

Wikipedia: Clostridium difficile (pronunciation below) (from the Greek kloster (κλωστήρ), spindle, and Latin...⁴⁴ more...

MalaCards: Clostridium Difficile, also known as c. difficile, is related to diarrhea and clostridium sordellii. An important gene associated with Clostridium Difficile is LTF (lactotransferrin), and among its related pathways are Signal transduction_PTEN pathway and Colorectal cancer. The compounds egcg and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include colon, monocytes and t cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

clostridium difficile 30 c. difficile 30

Diseases related to clostridium difficile by text searches and GeneDecks gene sharing:

(show top 50)    (show all 670)

id	Related Disease	Score	Top Affiliating Genes
1	diarrhea	34.8	LACTB, LTF
2	clostridium sordellii	30.3	RALA, RALB, TNF
3	reactive arthritis	28.6	CD79A, IL1B, IL8, HSPA1B, TP53, TNF
4	ulcerative colitis	28.1	CD79A, CD14, FOS, IL11, IL16, IL1B
5	nephropathy	21.6	JUN, CD79A, CDKN1A, CD14, CDC42, CD40LG
6	hypoxia	19.2	RAC1, BCL2, LDHA, BAX, AURKA, JUN
7	multiple myeloma	18.6	RALA, RAC1, RALB, BCL2, BAX, AURKA
8	myeloma	18.3	RALA, RAC1, RALB, BCL2, BAX, AURKA
9	neuronitis	17.5	RAC1, BCL2, LDHA, LDHD, BAX, AURKA
10	microsporidiosis	13.8	LTF, DEFA1, DEFA5
11	collagenous colitis	13.5	CD79A, CD40LG, LTF
12	congenital toxoplasmosis	13.5	CD79A, CD40LG
13	acute mountain sickness	13.5	HSPA1A, HSPA1B, HIF1A
14	chronic myelomonocytic leukemia	13.4	IL3, DEFA1, DEFA3, CSF2
15	cardiac tamponade	13.4	CD79A, CD40LG, HSPG2
16	acute megakaryoblastic leukemia	13.4	IL11, IL3, RHOA, CSF2
17	al amyloidosis	13.3	CD79A, CD14, CD40LG, IL3
18	severe congenital neutropenia	13.3	IL3, HSPA1A, HSPA1B, CSF2
19	stachybotrys chartarum	13.3	IL1B, IL3, CXCL2
20	dyserythropoietic anemia with thrombocytopenia	13.3	IL11, IL3, FAS, CSF2
21	felty's syndrome	13.3	IL3, IL8, CSF2
22	polyarteritis nodosa	13.3	CD40LG, IL8, LTF
23	bacterial meningitis	13.2	LACTB, IL1B, IL8, CXCL2
24	aplastic anemia	13.2	IL11, IL3, FAS, CSF2
25	autoimmune hepatitis	13.2	CD14, CD40LG, FAS, HSPG2
26	ovarian serous cystadenocarcinoma	13.2	BCL2, BAX, FAS
27	muckle-wells syndrome	13.2	IL1B, IL3, IL8
28	maxillary sinus squamous cell carcinoma	13.1	BAX, CDKN1A, TP53
29	chronic sphenoidal sinusitis	13.1	LACTB, IL8, MAPK1
30	wells syndrome	13.1	IL1B, IL3, IL8
31	cutis laxa	13.1	JUN, CD79A, CD40LG, FOS
32	keratoconjunctivitis	13.1	CD79A, IL3, IL8, HSPG2, LTF
33	candidiasis	13.1	CD79A, CD40LG, IL3, LTF, DEFA5, CXCL2
34	pulmonary emphysema	13.1	BAX, IL8, CASP3, GLUD1
35	acute myeloid leukemia, adult	13.1	IL3, TP53
36	hypersplenism	13.1	IL11, ALB, CSF2
37	natural killer cell leukemia	13.0	BCL2, CD79A, TP53
38	calciphylaxis	13.0	CD79A, CD40LG, ALB
39	lymphoproliferative syndrome	13.0	BCL2, CD40LG, FAS, SRC
40	hematologic cancer	13.0	LACTB, IL11, IL3, HSPG2, CSF2
41	polycythemia vera	13.0	CD79A, IL11, IL3, SRC, LTF, CSF2
42	plasmacytoma	13.0	BCL2, CD79A, CDKN1A, IL11
43	bile duct cancer	13.0	BCL2, BAX, CDKN1A
44	cerebral artery occlusion	13.0	FOS, IL16, MAPK1, HIF1A
45	gastrointestinal lymphoma	13.0	BCL2, CDKN1A, TP53
46	allergic asthma	13.0	CD14, IL16, IL3, IL8, CSF2
47	tangier disease	13.0	RAC1, ALB, RHOA, ABCG4
48	thoracic cancer	13.0	CDKN1A, CASP3, PTGS2
49	marginal zone b-cell lymphoma	12.9	CD79A, CD40LG, FAS, TP53, RHOH
50	capillary leak syndrome	12.9	IL8, ALB, CSF2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to clostridium difficile:

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MGI Mouse Phenotypes related to clostridium difficile:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	CD14, LDHA
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	GLUD1, CDC42, CD40LG
3	craniofacial phenotype	MP:0005382	10.1	HSPG2, CSF2
4	liver/biliary system phenotype	MP:0005370	9.5	TP53, HIF1A, HSPG2, GLA
5	hematopoietic system phenotype	MP:0005397	9.5	RHOH, IL3, CDKN1A, LDHA, BCL2, CSF2
6	embryogenesis phenotype	MP:0005380	9.3	PTK2, FOS, HSP90B1, SRC, PXN, AURKA
7	limbs/digits/tail phenotype	MP:0005371	9.2	HSPG2, CDC42, SRC, BAX, FAS, RAC1
8	renal/urinary system phenotype	MP:0005367	9.0	HIF1A, BCL2, CASP3, CDKN1A, GLA, BAX
9	digestive/alimentary phenotype	MP:0005381	8.4	PXN, HSPG2, BCL2, CDKN1A, CDC42, CASP3
10	nervous system phenotype	MP:0003631	8.3	CDKN1A, CDC42, FOS, MAPK1, HSPG2, HSPA1A
11	behavior/neurological phenotype	MP:0005386	8.1	MAPK1, SRC, GLA, HSPG2, CSF2, JUN
12	integument phenotype	MP:0010771	8.1	BCL2, RAC1, CSF2, CDKN1A, FOS, FAS
13	mortality/aging	MP:0010768	7.9	MAPK1, PXN, HSPA1B, CDKN1A, CD14, CSF2
14	immune system phenotype	MP:0005387	7.5	PTK2, RHOH, SRC, TP53, HSPA1B, HSP90B1
15	reproductive system phenotype	MP:0005389	7.5	TNF, PTGS2, FOS, MAPK1, PTK2, CASP3
16	skeleton phenotype	MP:0005390	6.6	JUN, BAX, HDAC6, FAS, TP53, FOS
17	tumorigenesis	MP:0002006	5.8	IL1B, FOS, CDKN1A, AURKA, IL3, FAS
18	vision/eye phenotype	MP:0005391	5.7	HIF1A, BAX, SRC, JUN, CDKN1A, FOS
19	muscle phenotype	MP:0005369	5.7	MAPK1, MAPK14, HSPG2, TP53, TNF, PTGS2
20	growth/size phenotype	MP:0005378	5.2	BAX, MAPK14, MAPK1, HSPG2, HSP90B1, CDC42
21	cardiovascular system phenotype	MP:0005385	4.4	CSF2, HSPG2, HSP90B1, HSPA1A, RAC1, HSPA1B
22	cellular phenotype	MP:0005384	3.0	CASP3, CSF2, GLA, PXN, HIF1A, ABCG4
23	homeostasis/metabolism phenotype	MP:0005376	2.8	IL3, FAS, MAPK14, IL1B, FOS, CD40LG

Articles related to clostridium difficile:

(show top 50)    (show all 65)

id	Title	Authors	Year	Affiliating Genes
1	Apoptosis-inducing effect of clostridium difficile t oxin A on K562 cells and its mechanism]. (21729540)	Li P.... Deng W.	2011	BCL2, CASP3, BAX
2	Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B. (21267712)	Gerhard R.... Just I.	2011	IL16
3	Evaluation of the C.Diff Quik Chek Complete Assay, a new glutamate dehydrogenase and A/B toxin combination lateral flow assay for us e in rapid, simple diagnosis of clostridium difficile disease. (20375230)	Sharp S.E.... Ivie W.M.	2010	GLUD2
4	Hypoxia-inducible factor signaling provides protectio n in Clostridium difficile-induced intestinal injury. (20347817)	Hirota S.A.... Beck P.L.	2010	HIF1A
5	Clostridium difficile testing in the clinical laborat ory by use of multiple testing algorithms. (20071552)	Novak-Weekley S.M.... Weissfeld A.	2010	GLUD1
6	Clostridium difficile toxin A decreases acetylation o f tubulin, leading to microtubule depolymerization through activation of histon e deacetylase 6, and this mediates acute inflammation. (20696758)	Nam H.J.... Kim H.	2010	HDAC6
7	Clostridium difficile toxin A binds colonocyte Src ca using dephosphorylation of focal adhesion kinase and paxillin. (19481075)	Kim H.... Lamont J.T.	2009	SRC, PTK2, PXN
8	Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections. (19258353)	Critchley I.A.... Ochsner U.A.	2009	MARS
9	Risk factors for mortality following emergency colectomy for fulminant Clostridium difficile infection. (19333038)	Pepin J.... LabbAc A.C.	2009	ALB
10	Detection of Clostridium difficile infection: a sugge sted laboratory diagnostic algorithm. (20095124)	Wren M.W.... Shetty N.R.	2009	LTF, GLUD2
11	gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A. (18411291)	Na X.... Lamont J.T.	2008	HSP90B1
12	First isolation of Clostridium difficile PCR-ribotype 027/toxinotype III in Poland. (19004250)	Pituch H.... L/uczak M.	2008	CDB2
13	Systemic antibody response to Clostridium difficile i n colonized patients with and without symptoms and matched controls. (18480328)	SA!nchez-Hurtado K.... Poxton I.R.	2008	CD40LG
14	Epidemiological study of Clostridium difficile strains isolated in Jean-Verdier-Rene-Muret hospitals from 2001 to 2007. (18842360)	Poilane I.... Collignon A.	2008	CDB2
15	Human alpha-defensins inhibit Clostridium difficile toxin B. (18435932)	Giesemann T.... Aktories K.	2008	DEFA1, DEFA5, DEFA3
16	Antimicrobial susceptibility of Clostridium difficil e clinical isolates collected from 2001 to 2007 in a French university hospital (18845403)	Cattoir V.... Legrand P.	2008	LACTB
17	Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A. (17639289)	Lee J.Y.... Kim J.M.	2007	FOS, JUN, IL8
18	Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells. (17634283)	Ando Y.... Narumiya S.	2007	AURKA
19	Yield of stool culture with isolate toxin testing ver sus a two-step algorithm including stool toxin testing for detection of toxigen ic Clostridium difficile. (17804652)	Reller M.E.... Carroll K.C.	2007	GLUD2
20	Association between IgG2 and IgG3 subclass responses to toxin A and recurrent Clostridium difficile-associated disease. (17544998)	Katchar K.... Kelly C.P.	2007	CD79A
21	Incidence of Clostridium difficile-associated diarrhe a before and after autologous peripheral blood stem cell transplantation for ly mphoma and multiple myeloma. (16435018)	Arango J.I.... Freytes C.O.	2006	IL3
22	A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea. (16573784)	Jiang Z.D.... LaRocco M.	2006	IL8
23	Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. (16344056)	Kim H.... Lamont J.T.	2005	TP53, MAPK14, CDKN1A
24	Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. (16206099)	PAcpin J.... Lanthier L.	2005	LACTB
25	Clinical features of Clostridium difficile-associated diarrhoea due to binary toxin (actin-specific ADP-ribosyltransferase)-producing strains. (15673514)	Barbut F.... Petit J.C.	2005	CDB2
26	Profile of toxigenicity of Clostridium difficile strains isolated from paediatric patients with clinical diagnosis of antibiotic associated diarrhea (AAD) (16773831)	Wultanska D.... Luczak M.	2005	CDB2
27	Multilocus sequence analysis and comparative evolution of virulence-associated genes and housekeeping genes of Clostridium difficile. (16207902)	Lemee L.... Pons J.L.	2005	CDB2
28	Six years evaluation of Clostridium difficile associated diarrhea (15293901)	Ercis S.... HasAselik G.	2004	LACTB
29	Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction. (12490434)	Liu T.S.... Chang E.B.	2003	HSPA1A, RHOA, HSPA1B
30	Simultaneous assays for Clostridium difficile and faecal lactoferrin in ulcerative colitis. (12974208)	Vaishnavi C.... Singh K.	2003	LTF
31	Frequency of binary toxin genes among Clostridium difficile strains that do not produce large clostridial toxins. (14605169)	Geric B.... Rupnik M.	2003	CDB2
32	Clinical usefulness of components of the Triage immun oassay, enzyme immunoassay for toxins A and B, and cytotoxin B tissue culture a ssay for the diagnosis of Clostridium difficile diarrhea. (12520696)	Massey V.... Hussain Z.	2003	GLUD1
33	Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an IL-1beta-dependent pathway. (12801886)	Neunlist M.... Galmiche J.P.	2003	IL1B
34	Faecal lactoferrin assay as an adjunct to Clostridium difficile diarrhoea. (12593568)	Vaishnavi C.... Singh K.	2002	LTF
35	Clostridium difficile toxin A alters in vitro-adherent neutrophil morphology and function. (12001047)	Brito G.A.... Guerrant R.L.	2002	RHOD
36	Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. (11910356)	He D.... Lamont J.T.	2002	IL8
37	CD14 expression by human mononuclear phagocytes is modulated by Clostridium difficile toxin B. (10580270)	Siffert J.C.... Poindron P.	1999	CD14
38	Roles of intracellular calcium and NF-kappa B in the Clostridium difficile toxin A-induced up-regulation and secretion of IL-8 from human monocytes. (10553038)	Jefferson K.K.... Bobak D.A.	1999	IL8
39	Association of IgA nephropathy with Clostridium difficile colitis. (10518470)	Gaughan W.J.... Sharma K.	1999	CD79A
40	Specific inhibition of phorbol ester-stimulated phospholipase D by Clostridium sordellii lethal toxin and Clostridium difficile toxin B-1470 in HEK-293 cells. Restoration by Ral GTPases. (9516439)	Schmidt M.... Jakobs K.H.	1998	RALA, RALB
41	Fecal lactoferrin, interleukin-1beta, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis. (9384296)	Steiner T.S.... Guerrant R.L.	1997	LTF
42	Clostridium difficile toxin A binding to human intestinal epithelial cells. (9368537)	Smith J.A.... Long R.G.	1997	GLA
43	A role for Rho in receptor- and G protein-stimulated phospholipase C. Reduction in phosphatidylinositol 4,5-bisphosphate by Clostridium difficile toxin B. (8857584)	Schmidt M.... von Eichel-Streiber C.	1996	HSPG2
44	Definition of the single integration site of the path ogenicity locus in Clostridium difficile. (8973304)	Braun V.... von Eichel-Streiber C.	1996	ABCG4
45	Effects of Clostridium difficile toxin A and toxin B on phospholipase D activation in human promyelocytic leukemic HL60 cells. (8890188)	Ohguchi K.... Nozawa Y.	1996	RHOH, RHOD
46	Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. (8675084)	Mahida Y.R.... Borriello S.P.	1996	IL8
47	Granulocyte-macrophage colony-stimulating factor therapy in patients with chemotherapy-induced aplasia and Clostridium difficile enterocolitis. (8652281)	Geiger R.... Fink F.M.	1995	CSF2
48	Involvement of Ras-related Rho proteins in the mechanisms of action of Clostridium difficile toxin A and toxin B. (7890404)	Dillon S.T.... Gilbert R.J.	1995	RHOD
49	Clostridium difficile colitis: an efficient clinical approach to diagnosis. (7486465)	Manabe Y.C.... Bartlett J.G.	1995	LTF
50	Concurrence of Clostridium difficile toxin A enzyme-l inked immunosorbent assay, fecal lactoferrin assay, and clinical criteria with C. difficile cytotoxin titer in two patient cohorts. (7665642)	Schleupner M.A.... Guerrant R.L.	1995	LTF

Genes related to clostridium difficile according to GeneCards:

(show top 50)    (show all 53)

id	Symbol	Description	Score	GeneCards Section Context
1	LTF	lactotransferrin	11.0	Publications
2	CDB2	corneal dystrophy of Bowman layer type II (Thiel-Behnke)	11.0	Publications
3	GLUD2	glutamate dehydrogenase 2	11.0	Publications
4	DEFA3	defensin, alpha 3, neutrophil-specific	11.0	Publications
5	LDHD	lactate dehydrogenase D	11.0	Publications
6	DEFA5	defensin, alpha 5, Paneth cell-specific	11.0	Publications
7	ABCG4	ATP-binding cassette, sub-family G (WHITE), member 4	11.0	Publications
8	DEFA1	defensin, alpha 1	11.0	Publications
9	MARS	methionyl-tRNA synthetase	11.0	Publications
10	RHOD	ras homolog family member D	11.0	Publications
11	RHOH	ras homolog family member H	11.0	Publications
12	HDAC6	histone deacetylase 6	11.0	Publications
13	CXCL2	chemokine (C-X-C motif) ligand 2	11.0	Publications
14	LDHA	lactate dehydrogenase A	11.0	Publications
15	RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	11.0	Publications
16	GLUD1	glutamate dehydrogenase 1	11.0	Publications
17	RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	11.0	Publications
18	PXN	paxillin	11.0	Publications
19	HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	11.0	Publications
20	IL11	interleukin 11	11.0	Publications
21	HSPA1B	heat shock 70kDa protein 1B	11.0	Publications
22	GLA	galactosidase, alpha	11.0	Publications
23	IL16	interleukin 16	11.0	Publications
24	LACTB	lactamase, beta	11.0	Publications
25	CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	11.0	Publications
26	HSPA1A	heat shock 70kDa protein 1A	11.0	Publications
27	AURKA	aurora kinase A	11.0	Publications
28	CD14	CD14 molecule	11.0	Publications
29	RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	11.0	Publications
30	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
31	RHOA	ras homolog family member A	11.0	Publications
32	CD40LG	CD40 ligand	11.0	Publications
33	FOS	FBJ murine osteosarcoma viral oncogene homolog	11.0	Publications
34	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
35	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
36	BAX	BCL2-associated X protein	11.0	Publications
37	PTK2	PTK2 protein tyrosine kinase 2	11.0	Publications
38	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
39	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
40	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
41	IL8	interleukin 8	11.0	Publications
42	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	11.0	Publications
43	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
44	IL1B	interleukin 1, beta	11.0	Publications
45	JUN	jun proto-oncogene	11.0	Publications
46	MAPK14	mitogen-activated protein kinase 14	11.0	Publications
47	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
48	MAPK1	mitogen-activated protein kinase 1	11.0	Publications
49	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
50	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications

Pathways related to clostridium difficile according to GeneDecks:

(show top 50)    (show all 268)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.7	PXN
2	Colorectal cancer20	10.4	RHOA, RAC1, FOS
3	RAR-Gamma-RXR-Alpha Degradation36	9.7	IL3, CXCL2, CSF2, IL11, IL16, MAPK14
4	Akt Signaling36	9.3	IL11, CSF2, PTK2, TNF, IL16
5	IL-6 Pathway36	9.2	CSF2, CXCL2, MAPK1, IL8, IL3, IL16
6	Chemotaxis CXCR4 signaling pathway10	9.1	PTK2, PXN, RHOA, SRC, MAPK1, CDC42
7	Agrin Interactions at Neuromuscular Junction36	9.0	MAPK1, RAC1, PXN, SRC, PTK2, CDC42
8	Chemotaxis_CXCR4 signaling pathway41	9.0	PXN, SRC, PTK2, MAPK1, CDC42, RHOA
9	Signal transduction PTEN pathway10	9.0	PXN, SRC, CASP3, CDKN1A, JUN, MAPK1
10	ERK Signaling36	8.9	CXCL2, SRC, PTK2, HSPG2, IL1B, IL11
11	Endothelin-1 Signaling Pathway36	8.9	IL11, IL16, IL1B, IL3, MAPK1, CASP3
12	HIF1Alpha Pathway36	8.8	LDHA, HIF1A, MAPK1, TP53, HSPA1B, JUN
13	HGF Pathway36	8.7	JUN, MAPK1, PXN, PTK2, PTGS2, RAC1
14	VEGF signaling pathway20	8.6	PXN, SRC, PTK2, RAC1, MAPK14, MAPK1
15	Development_VEGF signaling via VEGFR2 - generic cascades41	8.6	RAC1, JUN, MAPK1, PTGS2, PTK2, SRC
16	p53 Signaling36	8.4	HDAC6, CASP3, HIF1A, TP53, FOS, CDKN1A
17	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	8.3	BCL2, MAPK1, JUN, BAX, FOS, MAPK14
18	HMGB1 Pathway36	8.2	RAC1, JUN, FOS, IL1B, MAPK14, MAPK1
19	ILK Signaling36	8.1	CDC42, PXN, PTGS2, HSPG2, MAPK1, IL3
20	Neurotrophin signaling pathway20	8.0	JUN, CDC42, MAPK1, TP53, RHOA, BAX
21	T cell receptor signaling pathway20	8.0	MAPK1, CDC42, MAPK14, CSF2, FOS, CD40LG
22	Immune response MIF-mediated glucocorticoid regulation10	8.0	PTGS2, TNF, MAPK1, IL8, FOS, JUN
23	TGF-Beta Pathway36	7.9	IL16, MAPK1, BCL2, BAX, JUN, FOS
24	Toll-like receptor signaling pathway20	7.9	RAC1, CD14, IL8, MAPK14, TNF, JUN
25	Immune response IL-1 signaling pathway10	7.9	IL8, MAPK14, IL1B, JUN, PTGS2, TNF
26	Immune response_MIF-mediated glucocorticoid regulation41	7.9	MAPK1, TNF, PTGS2, IL8, FOS, JUN
27	Immune response_IL-1 signaling pathway41	7.8	JUN, FOS, IL1B, IL8, MAPK14, TNF
28	Amyotrophic lateral sclerosis (ALS)20	7.7	TNF, RAC1, BCL2, BAX, MAPK14, CASP3
29	Tec Kinases Signaling36	7.6	RAC1, IL11, BCL2, BAX, CDC42, FOS
30	all-trans-Retinoic Acid Signaling in Brain36	7.6	CXCL2, BCL2, BAX, IL11, IL16, PTGS2
31	14-3-3 Induced Apoptosis36	7.5	BCL2, JUN, FOS, IL1B, MAPK14, TNF
32	PEDF Induced Signaling36	7.5	IL11, BAX, BCL2, IL3, FOS, IL16
33	Immune response_MIF in innate immunity response41	7.5	MAPK14, TP53, JUN, IL8, IL1B, CD14
34	Immune response MIF in innate immunity response10	7.5	IL8, IL1B, CD14, JUN, PTGS2, MAPK14
35	Apoptosis20	7.5	BCL2, IL3, FAS, BAX, CASP3, TP53
36	Pertussis20	7.5	FOS, IL1B, IL8, JUN, MAPK1, CASP3
37	Glucocorticoid Receptor Signaling36	7.4	IL3, IL1B, IL16, IL11, FOS, CDKN1A
38	Rho Family GTPases36	7.3	BAX, CDC42, FOS, JUN, RAC1, BCL2
39	Tuberculosis20	7.3	BCL2, BAX, RHOA, CD14, IL1B, MAPK14
40	PAK Pathway36	7.1	CASP3, TNF, PTK2, PXN, CXCL2, IL8
41	MIF Mediated Glucocorticoid Regulation36	7.1	IL8, IL3, IL1B, IL16, IL11, CD14
42	MAPK Family Pathway36	7.1	TNF, RAC1, BCL2, BAX, JUN, CDC42
43	Antioxidant Action of Vitamin-C36	7.0	IL8, FOS, IL3, TNF, CXCL2, CSF2
44	Molecular Mechanisms of Cancer36	7.0	TP53, CXCL2, HIF1A, PTK2, CASP3, MAPK1
45	Pathways in cancer20	6.7	JUN, CDKN1A, CDC42, FOS, FAS, MAPK1
46	STAT3 Pathway36	6.7	CSF2, CXCL2, SRC, TNF, MAPK1, MAPK14
47	MAPK signaling pathway20	6.5	MAPK1, CASP3, HSPA1B, HSPA1A, MAPK14, FAS
48	MAPK Signaling36	6.2	CDC42, JUN, BCL2, RAC1, FOS, IL1B
49	p38 Signaling36	6.0	RALB, RAC1, CXCL2, RALA, BCL2, BAX
50	MIF Regulation of Innate Immune Cells36	6.0	IL1B, IL16, IL11, FOS, CD14, JUN

Compounds related to clostridium difficile according to GeneDecks:

(show top 50)    (show all 367)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.4	HSPG2, MAPK14
2	phosphatidylserine32 9 9	12.0	LTF, CD14, CD79A, BCL2, RAC1
3	rapamycin32 42	11.0	RHOD, SRC, PTK2, GLUD1
4	pge232	9.6	CD14, RAC1, HSPG2, PTK2, RHOD, CXCL2
5	agar32	9.4	HIF1A, RHOA, SRC, GLA, CD40LG, CDC42
6	sp 60012532 42	10.4	CXCL2, TP53, CASP3, CDKN1A
7	estrogen32	9.2	RHOA, PTK2, HSPA1A, HSP90B1, IL11, CDC42
8	h2o232	9.0	IL3, MAPK14, CSF2, CXCL2, LTF, GLUD1
9	cyclosporin a32 42	10.0	HIF1A, LTF, SRC, PTK2, GLUD1, IL8
10	rottlerin32 42	9.8	MAPK14, IL8, CD40LG, JUN, RAC1, PTK2
11	ceramide32	8.7	GLA, MAPK1, MAPK14, TNF, RHOA, PXN
12	rantes32	8.5	RAC1, PXN, MAPK14, FAS, IL3, IL16
13	n acetylcysteine32	8.3	CXCL2, HIF1A, CD79A, LTF, RHOA, SRC
14	cytochalasin d32 42	9.1	RAC1, IL8, MAPK14, PTK2, RHOA, RHOD
15	histamine32 18	9.0	HSPG2, ALB, IL3, IL16, IL11, CD40LG
16	mg 13232 42	8.9	HSPA1A, MAPK1, MAPK14, FAS, IL8, IL1B
17	cd 43732	7.9	TP53, CASP3, MAPK14, FAS, FOS, CDKN1A
18	c2ceramide32	7.8	JUN, BAX, IL1B, MAPK14, CASP3, RHOA
19	geldanamycin32 9 9	9.4	PXN, HIF1A, JUN, CDKN1A, MAPK14, HSP90B1
20	cysteine32	7.3	PXN, LTF, RHOD, RAC1, HIF1A, RHOA
21	fmlp32	7.1	HSPA1A, HSPG2, MAPK1, MAPK14, IL8, IL3
22	sb 20358032 42	8.1	MAPK14, FOS, CDC42, CDKN1A, BCL2, RAC1
23	diphenyleneiodonium32	7.0	CASP3, MAPK1, JUN, HIF1A, IL1B, MAPK14
24	superoxide32 18	8.0	CSF2, IL1B, IL16, CDC42, CD14, RAC1
25	ciglitazone32	6.9	PTGS2, TNF, CASP3, MAPK1, MAPK14, IL8
26	lactate32	6.9	LDHA, HSPA1A, ALB, FAS, IL8, IL3
27	15-deoxy-delta-12,14-prostaglandin j232	6.6	CSF2, PTGS2, TNF, CASP3, HSPA1A, MAPK1
28	arsenite32 18	7.6	SRC, BCL2, RAC1, BAX, JUN, TP53
29	oxygen32 18	7.4	HSPA1A, HSP90B1, MAPK1, MAPK14, FAS, CDKN1A
30	paclitaxel32 34 9 9	9.4	AURKA, BAX, BCL2, RAC1, CDKN1A, SRC
31	resveratrol32 9 18 9	9.4	HIF1A, SRC, PTK2, PTGS2, TP53, CASP3
32	troglitazone32 42 9 9	9.3	PTGS2, TNF, CASP3, BCL2, BAX, MAPK1
33	adpribose32	6.3	BAX, MAPK14, MAPK1, CASP3, CDKN1A, GLUD1
34	ly29400232	6.2	CASP3, CDC42, JUN, FOS, IL1B, TNF
35	triptolide32	6.1	CASP3, MAPK1, MAPK14, IL8, IL1B, CD14
36	phosphatidylinositol32	6.0	CSF2, FAS, IL3, IL11, FOS, CDC42
37	cisplatin32 34 9 9	8.7	SRC, PTK2, PTGS2, TP53, CASP3, HSPA1A
38	wortmannin32 42	6.7	RHOD, RHOA, SRC, PTK2, CASP3, HSPG2
39	pdtc32	5.7	HIF1A, PTGS2, TNF, TP53, CASP3, MAPK1
40	herbimycin a32 42	6.6	IL3, IL1B, IL11, FOS, CD40LG, CD14
41	curcumin32	5.3	IL8, IL1B, FOS, CDKN1A, JUN, BAX
42	vegf32	5.1	IL11, IL1B, MAPK14, HSPG2, TP53, PTGS2
43	butyrate32	5.1	FOS, CD14, CDKN1A, JUN, BAX, BCL2
44	dexamethasone32 42 34 9 9	8.4	PTGS2, TNF, GLUD1, HSPA1A, HSPG2, MAPK1
45	actinomycin d32	4.4	TP53, CASP3, HSPA1A, MAPK1, MAPK14, FAS
46	retinoic acid32 42 18	6.1	TP53, CASP3, HSPG2, MAPK1, MAPK14, FAS
47	genistein32 9 18 9	7.0	CD40LG, CDC42, CDKN1A, JUN, BAX, BCL2
48	cycloheximide32	3.7	CSF2, HIF1A, RHOA, PTK2, IL3, IL1B
49	pd 98,05932	3.6	CSF2, CXCL2, PXN, HIF1A, RHOD, RHOA
50	serine32	3.4	GLA, FOS, CD40LG, CDC42, CD14, CDKN1A

Cellular components related to clostridium difficile according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	9.9	DEFA5, IL1B, CDC42, LTF
2	midbody	GO:030496	9.8	RALA, RALB, AURKA, CDC42, HSP90B1, RHOA
3	caveola	GO:005901	8.9	HDAC6, SRC, PTGS2, MAPK1
4	extracellular region	GO:005576	7.7	DEFA3, FAS, IL8, IL3, IL1B, IL11
5	mitochondrion	GO:005739	7.2	LDHD, RHOH, BCL2, LDHA, BAX, LACTB
6	extracellular space	GO:005615	7.2	CSF2, CXCL2, DEFA5, CD14, CD40LG, IL11
7	cytosol	GO:005829	5.2	LDHA, CDC42, FAS, MARS, MAPK14, MAPK1

Biological processes related to clostridium difficile according to GeneDecks:

(show top 50)    (show all 51)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal complex assembly	GO:007172	10.3	SRC, PTK2, PXN
2	regulation of protein heterodimerization activity	GO:043497	10.2	BAX, BCL2, CDC42
3	B cell proliferation	GO:042100	10.1	CD40LG, CD79A, BCL2
4	regulation of nitrogen utilization	GO:006808	10.1	BAX, BCL2
5	nuclear fragmentation involved in apoptotic nuclear change	GO:030264	10.0	BAX, CASP3
6	positive regulation of DNA replication	GO:045740	9.9	CSF2, IL3, CDC42, JUN
7	response to toxin	GO:009636	9.8	FAS, HDAC6, CDKN1A, BAX, BCL2
8	B cell homeostasis	GO:001782	9.7	CASP3, BAX, BCL2
9	transformed cell apoptotic process	GO:006927	9.7	BAX, TNF, FAS
10	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.6	FOS, MAPK14, MAPK1, JUN
11	positive regulation vascular endothelial growth factor production	GO:010575	9.6	HIF1A, PTGS2, IL1B
12	negative regulation of neuron apoptotic process	GO:043524	9.6	BCL2, BAX, JUN, HIF1A, RHOA
13	cellular response to organic substance	GO:071310	9.6	BAX, BCL2, IL1B, CASP3
14	regulation of small GTPase mediated signal transduction	GO:051056	9.5	RHOD, RHOA, CDC42, RAC1, RHOH
15	stress-activated MAPK cascade	GO:051403	9.5	FOS, MAPK14, MAPK1, JUN
16	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.5	MAPK14, JUN, FOS, CD14, MAPK1
17	toll-like receptor 3 signaling pathway	GO:034138	9.5	JUN, MAPK1, MAPK14, FOS, CD14
18	Toll signaling pathway	GO:008063	9.4	CD14, FOS, MAPK14, MAPK1, JUN
19	toll-like receptor 4 signaling pathway	GO:034142	9.4	JUN, FOS, MAPK14, MAPK1, CD14
20	positive regulation of NF-kappaB import into nucleus	GO:042346	9.4	RHOA, TNF, IL1B
21	response to gamma radiation	GO:010332	9.4	TP53, IL1B, BAX, BCL2
22	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.3	TNF, CDC42, IL11, BCL2
23	MyD88-independent toll-like receptor signaling pathway	GO:002756	9.3	JUN, FOS, MAPK14, MAPK1
24	induction of apoptosis via death domain receptors	GO:008625	9.3	TNF, FAS, CASP3
25	angiogenesis	GO:001525	9.2	IL8, MAPK14, HIF1A, HSPG2, PTK2, JUN
26	cellular response to ionizing radiation	GO:071479	9.2	TP53, CDKN1A, MAPK14
27	toll-like receptor 2 signaling pathway	GO:034134	9.2	MAPK1, MAPK14, FOS, JUN
28	positive regulation of fever generation	GO:031622	9.2	PTGS2, TNF, IL1B
29	response to salt stress	GO:009651	9.1	TP53, TNF, BAX
30	toll-like receptor 1 signaling pathway	GO:034130	9.1	MAPK1, MAPK14, FOS, JUN
31	neuron apoptotic process	GO:051402	9.1	TP53, CASP3, FAS, BAX, BCL2
32	positive regulation of neuron apoptotic process	GO:043525	9.0	BAX, TNF, JUN, CASP3
33	induction of apoptosis by intracellular signals	GO:008629	9.0	TP53, BAX, CDKN1A, CASP3, BCL2
34	positive regulation of smooth muscle cell proliferation	GO:048661	8.9	JUN, TNF, PTGS2, HIF1A
35	induction of apoptosis by extracellular signals	GO:008624	8.9	TNF, RAC1, FAS, BAX, CASP3
36	release of cytochrome c from mitochondria	GO:001836	8.9	CASP3, BAX, TP53, JUN, BCL2
37	nerve growth factor receptor signaling pathway	GO:048011	8.9	MAPK1, RALB, RAC1, CASP3, RALA, MAPK14
38	innate immune response	GO:045087	8.9	DEFA3, DEFA5, HSP90B1, MAPK1, JUN, MAPK14
39	virus-host interaction	GO:019048	8.8	TP53, RALA, BAX, IL16, MAPK1, SRC
40	response to hypoxia	GO:001666	8.8	HSP90B1, BCL2, FAS, HIF1A, TNF, IL1B
41	anti-apoptosis	GO:006916	8.8	HSP90B1, HSPA1B, TNF, FAS, CD40LG, BCL2
42	Ras protein signal transduction	GO:007265	8.8	RALA, SRC, TP53, MAPK1, CDKN1A, RALB
43	response to DNA damage stimulus	GO:006974	8.6	BCL2, CDKN1A, BAX, TP53, CASP3
44	platelet activation	GO:030168	8.6	ALB, MAPK14, PTK2, SRC, MAPK1, IL11
45	inflammatory response	GO:006954	8.3	CXCL2, RAC1, CD14, CD40LG, FOS, IL1B
46	positive regulation of apoptotic process	GO:043065	8.2	BAX, TP53, TNF, PTGS2, HDAC6, FAS
47	blood coagulation	GO:007596	8.0	MAPK14, MAPK1, TP53, ALB, RHOA, CDC42
48	negative regulation of cell proliferation	GO:008285	7.6	JUN, TP53, CDKN1A, IL8, HSPA1B, TNF
49	negative regulation of apoptotic process	GO:043066	7.4	PTK2, CSF2, TNF, TP53, CASP3, ALB
50	apoptotic process	GO:006915	6.6	RALB, RAC1, BCL2, IL1B, FAS, MAPK14

Molecular functions related to clostridium difficile according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	glutamate dehydrogenase (NAD+) activity	GO:004352	10.2	GLUD1, GLUD2
2	glutamate dehydrogenase [NAD(P)+] activity	GO:004353	10.0	GLUD1, GLUD2
3	GTPase activity	GO:003924	9.7	RALA, RAC1, RALB, CDC42, RHOA, RHOD
4	GTP binding	GO:005525	9.6	RALA, RHOH, RHOD, RHOA, GLUD1, CDC42
5	ubiquitin protein ligase binding	GO:031625	9.0	TP53, HSPA1B, AURKA, BCL2, HIF1A
6	cytokine activity	GO:005125	8.6	IL16, IL3, CSF2, TNF, IL1B, CD40LG
7	protease binding	GO:002020	8.6	HSPA1B, TP53, TNF, BCL2
8	protein binding	GO:005515	2.9	RHOA, FAS, IL8, FOS, CDKN1A, JUN