MCID: CLS008
MIFTS: 40

Clostridium Difficile malady

Summaries for Clostridium Difficile

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33MalaCards
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MalaCards: Clostridium Difficile, also known as c. difficile, is related to ulcerative colitis and cystic fibrosis. An important gene associated with Clostridium Difficile is LTF (lactotransferrin), and among its related pathways are Reversible Hydration of Carbon Dioxide and glutamine degradation I. The compounds hbd2 and bifidobacterium have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and lung.

Aliases & Classifications for Clostridium Difficile

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43NIH Rare Diseases
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Aliases & Descriptions:

clostridium difficile 43
c. difficile 43


Related Diseases for Clostridium Difficile

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Clostridium Difficile:



Diseases related to clostridium difficile

Clinical Features for Clostridium Difficile

Drugs & Therapeutics for Clostridium Difficile

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Clostridium Difficile

Drug clinical trials:

Search ClinicalTrials for Clostridium Difficile

Search NIH Clinical Center for Clostridium Difficile

Search CenterWatch for Clostridium Difficile

Genetic Tests for Clostridium Difficile

Anatomical Context for Clostridium Difficile

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33MalaCards
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MalaCards organs/tissues related to Clostridium Difficile:

33
Skin, Kidney, Lung, Whole blood, Heart, Small intestine, Colon, Pancreas, Myeloid, Monocytes, T cells, B cells

Animal Models for Clostridium Difficile or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Clostridium Difficile

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51PubMed
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Articles related to Clostridium Difficile:

(show top 50)    (show all 660)
idTitleAuthorsYear
1
Prevention of Clostridium difficile infection in rural hospitals. (24406257)
2014
2
Spread of epidemic Clostridium difficile NAP1/027 in Latin America: case reports in Panama. (24287669)
2014
3
Faecal microbiota transplantation and bacteriotherapy for recurrent Clostridium difficile infection: A retrospective evaluation of 31 patients. (24354958)
2014
4
Comparative in-vitro activity of SMT19969, a new antimicrobial agent, against 162 less frequently recovered intestinal Clostridium strains: Implications for Clostridium difficile recurrence. (24247123)
2013
5
Lack of Clostridium difficile infection in patients treated with rifaximin for hepatic encephalopathy: a retrospective analysis. (23314671)
2013
6
The role of vancomycin and metronidazole for the treatment of clostridium difficile-associated diarrhea. (23940121)
2013
7
Duodenal infusion of feces for recurrent Clostridium difficile. (23718172)
2013
8
The correlation between Clostridium-difficile infection and human gut concentrations of Bacteroidetes phylum and clostridial species. (24048726)
2013
9
Mortality in patients with Clostridium difficile infection correlates with host pro-inflammatory and humoral immune responses. (23722431)
2013
10
Nontoxigenic Clostridium difficile protects hamsters against challenge with historic and epidemic strains of toxigenic BI/NAP1/027 C. difficile. (23939887)
2013
11
Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea. (23804381)
2013
12
Investigating Clostridium difficile. (24273764)
2013
13
Treatment approaches including fecal microbiota transplantation for recurrent Clostridium difficile infection (RCDI) among infectious disease physicians. (24012687)
2013
14
Small animal models for the study of Clostridium difficile disease pathogenesis. (24372713)
2013
15
Viral co-infections are common and are associated with higher bacterial burden in children with clostridium difficile infection. (23838821)
2013
16
The second messenger cyclic Di-GMP regulates Clostridium difficile toxin production by controlling expression of sigD. (24039264)
2013
17
Predicting a complicated course of Clostridium difficile infection at the bedside. (24188103)
2013
18
Reducing Clostridium difficile incidence, colectomies, and mortality in the hospital setting: a successful multidisciplinary approach. (23888639)
2013
19
Clostridium difficile: Restoring the balance--microbes for the management of Clostridium difficile infection? (23774772)
2013
20
Appropriateness of empiric therapy in patients with suspected Clostridium difficile infection. (23663129)
2013
21
Role of the environment in the transmission of Clostridium difficile in health care facilities. (23622740)
2013
22
Overview of severe Clostridium difficile infection. (24094379)
2013
23
Genetically diverse Clostridium difficile strains harboring abundant prophages in an estuarine environment. (23913427)
2013
24
Comparison of Oral Vancomycin Capsule and Solution for Treatment of Initial Episode of Severe Clostridium difficile Infection. (24375999)
2013
25
What is hot in the anaerobe literature? Clostridium difficile infections. (23587754)
2013
26
Reply to "Comparison of detection methods for Clostridium difficile". (23592855)
2013
27
Clostridium difficile infection in the community: are proton pump inhibitors to blame? (24187445)
2013
28
Healthcare-associated infections studies project: an American Journal of Infection Control and National Healthcare Safety Network data quality collaboration-LabID Clostridium Difficile event 2013. (23928030)
2013
29
Bacteremia as an adverse event of fecal microbiota transplantation in a patient with Crohn's disease and recurrent Clostridium difficile infection. (24184170)
2013
30
Extraintestinal Clostridium difficile infections. (23771984)
2013
31
Surface-layer protein A (SlpA) is a major contributor to host-cell adherence of Clostridium difficile. (24265687)
2013
32
Clostridium difficile-associated diarrhea in an ocelot (Leopardus pardalis). (23467074)
2013
33
Effects of nitric oxide and reactive oxygen species on HIF-1I+ stabilization following clostridium difficile toxin exposure of the Caco-2 epithelial cell line. (23988581)
2013
34
Emergence of a highly resistant Clostridium difficile strain (NAP/BI/027) in a tertiary care center in Saudi Arabia. (23563012)
2013
35
Clostridium difficile infection: a multicenter study of epidemiology and outcomes in mechanically ventilated patients. (23863229)
2013
36
Development of Clostridium difficile colitis in peritoneal dialysis patients treated for peritonitis. (23212865)
2012
37
Fecal Transplant for Clostridium difficile-Reply. (23752359)
2012
38
Rectal prolapse in a child: an unusual presentation of Clostridium difficile-associated pseudomembranous colitis. (21524633)
2011
39
Clinically important interaction between statin drugs and Clostridium difficile toxin? (19656639)
2009
40
Chronic multifocal osteomyelitis due to Clostridium difficile in an adolescent with sickle cell anemia. (18724265)
2008
41
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A. (18411291)
2008
42
Clinical features of Clostridium difficile-associated diarrhoea due to binary toxin (actin-specific ADP-ribosyltransferase)-producing strains. (15673514)
2005
43
Clostridium difficile associated severe enterocolitis: a feature of Hirschsprung's disease in a neonate presenting late. (16398878)
2005
44
Cytotoxicity and antimicrobial susceptibility of Clostridium difficile isolated from hospitalized children with acute diarrhea. (16701515)
2004
45
Pancytopenia and colitis with Clostridium difficile in a rheumatoid arthritis patient taking methotrexate, antibiotics and non-steroidal anti-inflammatory drugs. (11254248)
2001
46
Involvement of Ras-related Rho proteins in the mechanisms of action of Clostridium difficile toxin A and toxin B. (7890404)
1995
47
Rectal prolapse in children associated with Clostridium difficile infection. (7716002)
1995
48
Clostridium difficile in toxic megacolon. (6814650)
1982
49
Clostridium difficile in toxic megacolon complicating acute inflammatory bowel disease. (6809132)
1982
50
Clostridium difficile colitis in a rabbit following antibiotic therapy for pasteurellosis. (7332710)
1981

Genetic Variations for Clostridium Difficile

Expression for genes affiliated with Clostridium Difficile

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clostridium Difficile

Search GEO for disease gene expression data for Clostridium Difficile.

Pathways for genes affiliated with Clostridium Difficile

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Clostridium Difficile according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4GLUD1, GLUD2
2
Hide members
10.4GLUD2, GLUD1
310.3LTF, DEFA1, DEFA3
4
Hide members
10.3DEFA3, DEFA1, DEFA5
510.3DEFA5, DEFA3, DEFA1

Compounds for genes affiliated with Clostridium Difficile

Sources:
45Novoseek, 50PharmGKB, 2BitterDB, 11DrugBank, 29IUPHAR
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Compounds related to Clostridium Difficile according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1hbd24510.6DEFA3, DEFA1, DEFA5
2bifidobacterium4510.6GLA, LTF
3geranylgeranyl pyrophosphate4510.6RHOH, RALA, RHOD
4anti-fungal4510.6LTF, DEFA3, DEFA1
5toxin a4510.5CDB2, GLUD2, GLUD1, RHOD, RHOH
6erythromycin45 50 2 1113.5CXCL2, LACTB, LTF
7endotoxin4510.5CXCL2, IL11, GLUD1, LTF
8ampicillin45 1111.5LACTB, LTF
9cytochalasin4510.4RHOD, LTF
10aspartate4510.4IL11, GLUD2, GLA, GLUD1, AURKA, LTF
11gtp45 2911.4RHOH, RHOD, GLUD1, RALB, RALA, GLUD2
12paclitaxel45 50 1112.4AURKA, HDAC6, IL11, RHOD
13fibrinogen4510.4GLUD1, CXCL2, IL11, LTF
14threonine4510.4AURKA, HDAC6, RHOD, IL11, GLUD1, GLA
15amoxicillin45 50 1112.4LACTB, LTF
16metronidazole45 1111.3LTF, LACTB
17glutamate4510.3GLUD2, RHOD, GLA, DEFA1, LTF, GLUD1
18gamma-hydroxybutyrate4510.3GLUD1, LTF
19serine4510.2LACTB, LTF, GLUD1, GLA, RHOD, HDAC6
20ofloxacin45 2 1112.0LTF, LACTB

GO Terms for genes affiliated with Clostridium Difficile

Sources:
16Gene Ontology
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Cellular components related to Clostridium Difficile according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00573910.1LDHD, LACTB, GLUD2, GLUD1, MARS, RHOH
2midbodyGO:03049610.0RALB, RALA, AURKA

Biological processes related to Clostridium Difficile according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate catabolic processGO:00653810.4GLUD2, GLUD1
2glutamate biosynthetic processGO:00653710.4GLUD2, GLUD1
3defense response to fungusGO:05083210.3DEFA3, DEFA5
4killing of cells of other organismGO:03164010.2DEFA5, DEFA3
5defense response to bacteriumGO:04274210.0LTF, DEFA3, DEFA5

Molecular functions related to Clostridium Difficile according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1leucine bindingGO:07072810.4GLUD2, GLUD1
2glutamate dehydrogenase [NAD(P)+] activityGO:00435310.3GLUD1, GLUD2
3GTP bindingGO:00552510.1RALB, RALA, GLUD2, GLUD1, RHOD, RHOH
4glutamate dehydrogenase (NAD+) activityGO:00435210.1GLUD1, GLUD2

Products for genes affiliated with Clostridium Difficile

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Clostridium Difficile

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet