MCID: CLB002
MIFTS: 43

Clubfoot malady

Categories: Bone diseases, Genetic diseases

Aliases & Classifications for Clubfoot

Aliases & Descriptions for Clubfoot:

Name: Clubfoot 12 52 42 14
Congenital Talipes Equinovarus 12
Equinovarus Deformity of Foot 12
Congenital Equinovarus 12
Congenital Clubfoot 12
Club Foot 52

Classifications:



Summaries for Clubfoot

Disease Ontology : 12 A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.

MalaCards based summary : Clubfoot, also known as congenital talipes equinovarus, is related to marden-walker syndrome and clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly. An important gene associated with Clubfoot is CHST14 (Carbohydrate Sulfotransferase 14), and among its related pathways/superpathways are Cardiac conduction and Striated Muscle Contraction. The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and skeletal muscle, and related phenotypes are limbs/digits/tail and skeleton

Wikipedia : 71 Club foot or clubfoot, is a term for the medical condition congenital talipes equinovarus (CTEV). It is... more...

Related Diseases for Clubfoot

Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot

Diseases related to Clubfoot via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
id Related Disease Score Top Affiliating Genes
1 marden-walker syndrome 29.6 MYH3 TNNT3 TPM2
2 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 12.2
3 short stature robin sequence cleft mandible hand anomalies clubfoot 11.7
4 pitx1-related congenital clubfoot 11.7
5 familial clubfoot with or without associated lower limb anomalies 11.7
6 musculocontractural ehlers-danlos syndrome 11.6
7 talipes equinovarus 11.5
8 tarp syndrome 11.4
9 pseudohypoaldosteronism, type iie 11.3
10 epiphyseal dysplasia, multiple, 4 11.3
11 moebius syndrome 11.0
12 robin sequence with cleft mandible and limb anomalies 11.0
13 arthrogryposis, distal, type 3 11.0
14 arthrogryposis multiplex congenita, distal, type 1 10.9
15 spondyloepiphyseal dysplasia with congenital joint dislocations 10.9
16 chromosome 17q23.1-q23.2 duplication syndrome 10.9
17 smed strudwick type 10.8
18 arthrogryposis, distal, type 5d 10.8
19 hydrocephalus-cleft palate-joint contractures syndrome 10.8
20 loeys-dietz syndrome 5 10.8
21 diastrophic dysplasia 10.8
22 atelosteogenesis ii 10.8
23 genitopatellar syndrome 10.8
24 ehlers-danlos syndrome, musculocontractural type 1 10.7
25 lambert syndrome 10.7
26 orofaciodigital syndrome iv 10.7
27 vertical talus, congenital 10.7
28 spondyloperipheral dysplasia 10.7
29 arthrogryposis, distal, type 1b 10.7
30 spondylocarpotarsal synostosis syndrome 10.7
31 larsen syndrome 10.7
32 lethal congenital contracture syndrome 11 10.7
33 bruck syndrome 2 10.7
34 epileptic encephalopathy, early infantile, 29 10.7
35 arthrogryposis, distal, type 2b 10.7
36 short qt syndrome 3 10.2 PITX1 TBX4
37 congenital extrahepatic portosystemic shunt 10.2 CHST14 TNNT3
38 snowflake vitreoretinal degeneration 10.1 MYH3 TPM2
39 brachydactyly-syndactyly syndrome 10.1 HOXD10 HOXD13
40 myelodysplasia and leukemia syndrome with monosomy 7 10.1 HOXD10 HOXD13
41 duane retraction syndrome 2 10.1 HOXD10 HOXD13
42 congenital disorder of glycosylation, type iid 10.1 MYH3 TNNT3 TPM2
43 simpson-golabi-behmel syndrome 10.1 HOXD10 HOXD13
44 myelomeningocele 9.9
45 pityriasis rubra pilaris 9.9 CHST3 SLC26A2
46 combined oxidative phosphorylation deficiency 2 9.8 CHST3 SLC26A2
47 ehlers-danlos syndrome 9.8
48 nemaline myopathy 4, autosomal dominant 9.8 MYBPC1 MYH3 TNNT3 TPM2
49 carney complex variant 9.8 MYBPC1 MYH3 TNNT3 TPM2
50 atrioventricular septal defect 9.8 MYBPC1 MYH3 TNNT3 TPM2

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to Clubfoot

Symptoms & Phenotypes for Clubfoot

MGI Mouse Phenotypes related to Clubfoot:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.56 TBX4 TNNT3 CHST14 HOXC12 HOXD10 HOXD13
2 skeleton MP:0005390 9.23 CHST14 CHST3 HOXD10 HOXD13 PITX1 SLC26A2

Drugs & Therapeutics for Clubfoot

Drugs for Clubfoot (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2 Cholinergic Agents Phase 4,Phase 3,Phase 2
3 Neuromuscular Agents Phase 4,Phase 3,Phase 2
4 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
5 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
6 abobotulinumtoxinA Phase 4,Phase 3,Phase 2
7 incobotulinumtoxinA Phase 4,Phase 3,Phase 2
8 onabotulinumtoxinA Phase 4,Phase 3,Phase 2
9 Botulinum Toxins Phase 4,Phase 3,Phase 2
10 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2
11 Anesthetics Phase 3
12 Pharmaceutical Solutions Phase 2
13 Hemagglutinins Phase 2
14
Menthol Approved 2216-51-5 16666
15 Neuroserpin
16 Analgesics
17 Astragalus Nutraceutical

Interventional clinical trials:

(show all 40)
id Name Status NCT ID Phase
1 Post Marketing Surveillance Study of Dysport Completed NCT00210431 Phase 4
2 Effects of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus Foot Recruiting NCT03044080 Phase 4
3 Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patients Completed NCT00825097 Phase 3
4 Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity Completed NCT00460655 Phase 3
5 Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy Completed NCT02188277 Phase 2
6 Sucrose Analgesia in Infants Undergoing Casting for Club Foot Unknown status NCT01050088
7 Effectiveness of Parents' Manipulation in Newborn With Talipes Calcaneus Unknown status NCT01767662
8 Genetic Disease Gene Identification Unknown status NCT00916903
9 Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA) Unknown status NCT01600183
10 Clubfoot DNA Repository Completed NCT00607191
11 Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRI Completed NCT01088828
12 Gait Analysis in Ponseti Clubfoot Completed NCT02022267
13 Outcomes of Compliance With Brace Wear in Clubfoot Completed NCT01481324
14 Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot Completed NCT02815306
15 Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot) Completed NCT00474344
16 A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot Infants Completed NCT02395185
17 Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti Method Completed NCT01067651
18 Treatment of Spastic Equinovarus Foot After Stroke Completed NCT00199589
19 Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus Foot Completed NCT01265238
20 Impairments of Oral Language in Mobius Syndrome Completed NCT00856531
21 Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and Clubfeet Recruiting NCT02755766
22 Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic Clubfoot Recruiting NCT02815215 Early Phase 1
23 Using Botox to Treat Patients With Idiopathic Clubfoot Recruiting NCT00474032
24 Pedobarographic Assessments of Clubfoot Treated Patients Recruiting NCT00175708
25 Prospective Evaluation of Treatment for Clubfoot Recruiting NCT02257229
26 Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral Palsy Recruiting NCT02814786
27 Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar Pressure Recruiting NCT02233140
28 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503
29 Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus Foot Recruiting NCT02790346
30 Trial Readiness and Endpoint Assessment in Congenital Myotonic Dystrophy Recruiting NCT03059264
31 Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome Recruiting NCT01144741
32 Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized Trial Active, not recruiting NCT01551264
33 Efficacy of Botox in Patients With Idiopathic Clubfoot Active, not recruiting NCT00152334
34 A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic Clubfoot Active, not recruiting NCT00152347
35 Osteopathic Approach Into Neonatology Ward: the NE-O Model Available NCT01902563
36 Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles Tendon Suspended NCT01382628
37 Ankle Equinus Contracture Treated With Dynamic Splinting Terminated NCT01238484
38 The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon Fractures Terminated NCT02051933
39 Economic Evaluation of Clubfoot Treatment: One Centre's Experience Withdrawn NCT00475631
40 Instep Plantar Fasciotomy With and Without Gastrocnemius Recession Withdrawn NCT02287714

Search NIH Clinical Center for Clubfoot

Cochrane evidence based reviews: clubfoot

Genetic Tests for Clubfoot

Anatomical Context for Clubfoot

MalaCards organs/tissues related to Clubfoot:

39
Bone, Skin, Skeletal Muscle

Publications for Clubfoot

Articles related to Clubfoot:

(show top 50) (show all 614)
id Title Authors Year
1
The quality of Achilles tendon repair five to eight years after percutaneous tenotomy in the treatment of clubfoot: clinical and ultrasonographic findings. ( 28053270 )
2017
2
Treatment of congenital clubfoot using Ponseti method. ( 27274485 )
2016
3
Modified Lambrinudi Arthrodesis for the Acute Treatment of Neurogenic Clubfoot: A Case Report. ( 27920102 )
2016
4
How Many Patients Who Have a Clubfoot Treated Using the Ponseti Method are Likely to Undergo a Tendon Transfer? ( 27379785 )
2016
5
Problems encountered by parents of infants with clubfoot treated by the Ponseti method in Madagascar: A study to inform better practice. ( 27058615 )
2016
6
A mini-open technique for Achilles tenotomy in infants with clubfoot. ( 26825454 )
2016
7
Evolution of clubfoot deformity and muscle abnormality in the Ponseti method: evaluation with the Dimeglio score. ( 27349648 )
2016
8
The clubfoot over the centuries through the documentation present in the literature and art. ( 27392302 )
2016
9
Gait in 5-year-old children with idiopathic clubfoot: A cohort study of 59 children, focusing on foot involvement and the contralateral foot. ( 27331243 )
2016
10
The Objective Measurement of Brace-Use Adherence in the Treatment of Idiopathic Clubfoot. ( 27707845 )
2016
11
Evaluation of gait, relapse and compliance in clubfoot treatment with custom-made orthoses. ( 27544063 )
2016
12
Design and descriptive data of the randomized Clubfoot Foot Abduction Brace Length of Treatment Study (FAB24). ( 27632641 )
2016
13
Oral Sucrose for Pain Relief During Clubfoot Casting: A Double-Blinded Randomized Controlled Trial. ( 27636913 )
2016
14
The Ponseti technique and improved ankle dorsiflexion in children with relapsed clubfoot: a retrospective data analysis. ( 27649368 )
2016
15
Functional Assessment of Clubfoot Associated HOXA9, TPM1, and TPM2 Variants Suggests a Potential Gene Regulation Mechanism. ( 27020427 )
2016
16
Ponseti method compared to previous treatment of clubfoot in Norway. A multicenter study of 205 children followed for 8-11A years. ( 27436118 )
2016
17
Are incidence and severity of clubfoot related to the season of birth? ( 27351571 )
2016
18
Medial to posterior release procedure after failure of functional treatment in clubfoot: a prospective study. ( 27032405 )
2016
19
The impact of the Ponseti treatment method on parents and caregivers of children with clubfoot: a comparison of two urban populations in Europe and Africa. ( 26898213 )
2016
20
The effectiveness of the Ponseti method for treating clubfoot associated with arthrogryposis: up to 8 years follow-up. ( 26833334 )
2016
21
What factors affect patient access and engagement with clubfoot treatment in low- and middle-income countries? Meta-synthesis of existing qualitative studies using a social ecological model. ( 26892686 )
2016
22
Surgical treatment of neglected clubfoot using external fixator. ( 27818969 )
2016
23
An 18.3-Mb Duplication on Chromosome 14q With Multiple Cardiac Anomalies and Clubfoot Was Identified by Microarray Analysis. ( 26709274 )
2016
24
Bracing in Ponseti Clubfoot Treatment: Improving Parental Adherence Through an Innovative Health Education Intervention. ( 27028684 )
2016
25
Ponseti treatment for idiopathic clubfoot deformity - Role of secondary care hospitals. ( 26712195 )
2016
26
Comparison of the Ponseti method versus early tibialis anterior tendon transfer for idiopathic clubfoot: A prospective randomized study. ( 27496186 )
2016
27
Clubfoot treatment: Implementation of the Ponseti method in emerging countries. ( 27046927 )
2016
28
Osteogenesis imperfecta and clubfoot-a rare combination: Case report and review of the literature. ( 27495102 )
2016
29
Association between maternal age at conception and risk of idiopathic clubfoot. ( 26901038 )
2016
30
Mid-term results of Ponseti management for an idiopathic congenital clubfoot at a single center in Vietnam. ( 26709996 )
2016
31
Bracing in Ponseti Clubfoot Treatment: Improving Parental Adherence Through an Innovative Health Education Intervention. ( 27028685 )
2016
32
Treatment of complex idiopathic clubfoot using the modified Ponseti method: up to 11 years follow-up. ( 27104942 )
2016
33
The Ponseti Method for Clubfoot Treatment in Low and Middle-Income Countries: A Systematic Review of Barriers and Solutions to Service Delivery. ( 26919713 )
2016
34
Results of clubfoot treatment after manipulation and casting using the Ponseti method: experience in Harare, Zimbabwe. ( 27388947 )
2016
35
Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus. ( 26729820 )
2016
36
Initial treatment of congenital idiopathic clubfoot: Prognostic factors. ( 27765520 )
2016
37
Effect of a modified dynamic accordion hinge Denis Browne brace on the success rate of the Ponseti method in idiopathic clubfoot: a preliminary study. ( 27341119 )
2016
38
Ponseti Treatment of Rigid Residual Deformity in Congenital Clubfoot After Walking Age. ( 27869621 )
2016
39
Factors associated with recurrence of clubfoot treated by the Ponseti method. ( 27803913 )
2016
40
Descriptive epidemiology of clubfoot in Romania: a clinic-based study. ( 26875888 )
2016
41
Nail changes in casted and braced clubfoot: A preliminary study. ( 27810019 )
2016
42
What is new in idiopathic clubfoot? ( 27696325 )
2016
43
Development of congenital clubfoot during growth: a long-term study on the basis of pedobarography, biomechanics, and magnetic resonance imaging measurements of muscle volumes. ( 26919619 )
2016
44
Functional and clinical results achieved in congenital clubfoot patients treated by Ponseti's technique. ( 28050536 )
2016
45
The Dynamicity of Steenbeek Foot Abduction Brace for Clubfoot in Dorsiflexion and Pronation: A Pilot Study. ( 27036490 )
2016
46
Prognosticating Factors of Relapse in Clubfoot Management by Ponseti Method. ( 27662384 )
2016
47
Walk for life - the National Clubfoot Project of Bangladesh: the four-year outcomes of 150 congenital clubfoot cases following Ponseti method. ( 27833661 )
2016
48
Evaluation of Ponseti method in neglected clubfoot. ( 27746497 )
2016
49
Effectiveness of the Ponseti method for treating clubfoot associated with myelomeningocele: 3-9 years follow-up. ( 27386794 )
2016
50
Photovoice and Clubfoot: Using a Participatory Research Method to Study Caregiver Adherence to the Ponseti Method in PerA_. ( 26361460 )
2015

Variations for Clubfoot

Expression for Clubfoot

Search GEO for disease gene expression data for Clubfoot.

Pathways for Clubfoot

GO Terms for Clubfoot

Cellular components related to Clubfoot according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 9.16 MYBPC1 MYH3
2 muscle myosin complex GO:0005859 8.96 MYBPC1 MYH3
3 myosin filament GO:0032982 8.62 MYBPC1 MYH3

Biological processes related to Clubfoot according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.85 HOXC12 HOXD10 HOXD13 PITX1 TBX4
2 skeletal system development GO:0001501 9.5 HOXD10 HOXD13 PITX1
3 sarcomere organization GO:0045214 9.43 MYBPC1 MYH3
4 limb morphogenesis GO:0035108 9.4 HOXD13 TBX4
5 skeletal muscle contraction GO:0003009 9.37 MYH3 TNNT3
6 hindlimb morphogenesis GO:0035137 9.26 HOXD10 PITX1
7 embryonic limb morphogenesis GO:0030326 9.26 HOXD10 HOXD13 MYH3 TBX4
8 regulation of ATPase activity GO:0043462 9.16 TNNT3 TPM2
9 muscle filament sliding GO:0030049 8.92 MYBPC1 MYH3 TNNT3 TPM2

Molecular functions related to Clubfoot according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.46 HOXC12 HOXD10 HOXD13 PITX1
2 transcription factor activity, sequence-specific DNA binding GO:0003700 9.35 HOXD10 HOXD13 PITX1 TBX4 ZNF664
3 sulfotransferase activity GO:0008146 9.32 CHST14 CHST3
4 structural constituent of muscle GO:0008307 9.26 MYBPC1 TPM2
5 actin filament binding GO:0051015 8.8 MYBPC1 MYH3 TPM2

Sources for Clubfoot

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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