MCID: CLB002
MIFTS: 47

Clubfoot malady

Summaries for Clubfoot

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 A club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

MalaCards: Clubfoot, also known as congenital talipes equinovarus, is related to polydactyly and clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly. An important gene associated with Clubfoot is CHST14 (carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14). Affiliated tissues include bone, skeletal muscle and skin, and related mouse phenotypes are craniofacial and digestive/alimentary.

Description from OMIM:46 119800

Aliases & Classifications for Clubfoot

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM, 27ICD9CM
See all sources

Aliases & Descriptions:

clubfoot 8 10 44
congenital talipes equinovarus 8
equinovarus deformity of foot 8
congenital equinovarus 8
congenital clubfoot 8
club foot 44


Related Diseases for Clubfoot

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot Familial Clubfoot Due to 17q23.1q23.2 Microduplication
Familial Clubfoot Due to 5q31 Microdeletion

Diseases related to Clubfoot via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly30.0HOXD12, HOXD11
2clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.3
3adducted thumb and clubfoot syndrome10.3
4myotonic dystrophy type 210.2
5myotonic dystrophy10.2
6kabuki syndrome10.2
7familial clubfoot due to 17q23.1q23.2 microduplication10.2
8pseudohypoaldosteronism type ii10.1
9richieri costa pereira syndrome10.1
10short stature robin sequence cleft mandible hand anomalies clubfoot10.1
11familial clubfoot due to 5q31 microdeletion10.1
12multiple epiphyseal dysplasia10.0
13neuronitis10.0
14dysostosis10.0
15adducted thumbs dundar type10.0
16radial defect robin sequence10.0
17spondyloepiphyseal dysplasia with congenital joint dislocations10.0
18cleft palate10.0
19ehlers-danlos syndrome10.0
20atelosteogenesis type 210.0
21arthrogryposis multiplex congenita distal type 110.0
22talipes equinovarus10.0
23tarp syndrome10.0
24pitx1-related congenital clubfoot10.0
25ehlers-danlos syndrome, musculocontractural type 210.0
26brachydactyly10.0GDF5
27syndactyly10.0GDF5, HOXD12, HOXD1
28vacterl association10.0HOXA5, HOXD3
29synostosis10.0HOXA11
30radioulnar synostosis10.0HOXA11, TBX4
31diastrophic dysplasia9.9
32larsen syndrome9.9
33friedreich ataxia9.9
34coloboma9.9
35cerebritis9.9
36gastroschisis9.9
37central core myopathy9.9
38distal arthrogryposis9.9
39osteoarthritis9.9
40situs inversus9.9
41esophageal atresia9.9
42imperforate anus9.9
43spondyloepimetaphyseal dysplasia, strudwick type9.9
44esophagitis9.9
45myopathy9.9
46neuromuscular disease9.9
47oligohydramnios9.9
48spina bifida9.9
49congenital fiber-type disproportion9.9
50multiple epiphyseal dysplasia, recessive9.9

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Clinical Features for Clubfoot

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

119800

Drugs & Therapeutics for Clubfoot

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Clubfoot

Drug clinical trials:

Search ClinicalTrials for Clubfoot

Search NIH Clinical Center for Clubfoot

Search CenterWatch for Clubfoot

Genetic Tests for Clubfoot

About this section

Anatomical Context for Clubfoot

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Clubfoot:

32
Bone, Skeletal muscle, Skin

Animal Models for Clubfoot or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Clubfoot

About this section
Sources:
50PubMed
See all sources

Articles related to Clubfoot:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Real time evaluation of monolateral clubfoot with sonoelastography. (24408045)
2014
2
Achievement of gross motor milestones in children with idiopathic clubfoot treated with the Ponseti method. (23232380)
2013
3
Descriptive epidemiology of clubfoot in Peru: a clinic-based study. (24027478)
2013
4
Treatment of congenital clubfoot with the Ponseti method: the parents' perspective. (23974148)
2013
5
Treatment results of late-relapsing idiopathic clubfoot previously treated with the Ponseti method. (22584843)
2012
6
The French functional physical therapy method for the treatment of congenital clubfoot. (22134650)
2012
7
The current management of idiopathic clubfoot revisited: results of a survey of the POSNA membership. (22706469)
2012
8
Commentary on "Conservative treatment of clubfoot using modified Copenhagen method". (22207469)
2012
9
Clubfoot in the twentieth century: where we were and where we may be going in the twenty-first century. (21946867)
2012
10
External fixation in clubfoot treatment - a review of the literature. (22134652)
2012
11
The influence of brace type on the success rate of the Ponseti treatment protocol for idiopathic clubfoot. (22468155)
2011
12
Clubfoot in children. (22369026)
2011
13
Variants in genes that encode muscle contractile proteins influence risk for isolated clubfoot. (21834041)
2011
14
Long-term results of the posteromedial release in the treatment of idiopathic clubfoot. (20864856)
2010
15
Long-term outcome evaluation in young adults following clubfoot surgical release. (20502239)
2010
16
Double column osteotomy for correction of residual adduction deformity in idiopathic clubfoot. (20659361)
2010
17
Congenital clubfoot: a review. (20393429)
2010
18
Clubfoot treatment: Ponseti and French functional methods are equally effective. (19242767)
2009
19
Tibialis anterior tendon transfer after clubfoot surgery. (19242766)
2009
20
Dural and intradural compression as a cause of clubfoot. NJ Giannestras MD CORR 1953;1:28-32. Calcaneovalgus foot in the newborn and its relationship to developmental flatfoot. CF Ferciot MD CORR 1953;1:22-27. (19184258)
2009
21
Distal tibia/fibula fractures following clubfoot casting---report of four cases. (19742098)
2009
22
Update on clubfoot: etiology and treatment. (19224303)
2009
23
Treatment of clubfoot with the Ponseti method: a comparison of casting materials. (18388724)
2008
24
Evaluation of clinical and radiographic outcomes of complete subtalar release in clubfoot treatment. (19017853)
2008
25
Relapsed clubfoot correction with soft-tissue release and selective application of Ilizarov technique. (19057984)
2008
26
Outcome after Achilles tendon lengthening with a posterior capsulolysis according to ImhAouser in idiopathic congenital clubfoot. (18779770)
2008
27
Measurement of soft tissue elasticity in the congenital clubfoot using scanning acoustic microscope. (17762676)
2007
28
Congenital diastasis of the inferior tibiofibular joint with clubfoot and imperforate anus. (17331870)
2007
29
Long-term follow-up of the surgically corrected clubfoot. (17414783)
2007
30
Comparative results of the conservative treatment in clubfoot by two different protocols. (17762669)
2007
31
History of the functional method for conservative treatment of clubfoot. (19308491)
2007
32
Magnetic resonance imaging of the congenital clubfoot treated with the French functional (physical therapy) method. (17314649)
2007
33
A model for clubfoot based on micro-CT data. (17504271)
2007
34
Incidence of hip dysplasia in idiopathic clubfoot. (16919196)
2006
35
Three-dimensional hindfoot motion in adolescents with surgically treated unilateral clubfoot. (16199945)
2005
36
The Ponseti method of treatment for congenital clubfoot: importance of maximal forefoot supination in initial casting. (15682578)
2005
37
Assessment of talar flattening in adult idiopathic clubfoot. (16174507)
2005
38
Nonoperative clubfoot treatment using the French physical therapy method. (15614069)
2005
39
Sonographic assessment of clubfoot. (15124190)
2004
40
Calcaneus gait following treatment for clubfoot: preliminary results of surgical correction. (15091259)
2004
41
Administering caudal anesthesia at completion of clubfoot surgery does not affect postoperative use of narcotics. (12647877)
2003
42
Talo-calcaneal relationship in clubfoot. (11176355)
2001
43
Functional results of surgical treatment in congenital talipes equinovarus (clubfoot): a comparison of outcome measurements. (11143473)
2000
44
Clubfoot analysis with three-dimensional foot models. (10709590)
1999
45
An independent assessment of two clubfoot-classification systems. (9600557)
1998
46
Scar quality from partial or complete wound closure using the Cincinnati incision for clubfoot surgery. (9702673)
1998
47
Common errors in the treatment of congenital clubfoot. (9195271)
1997
48
Onset of ossification of the tarsal bones in congenital clubfoot. (8989699)
1997
49
Antenatal sonographic diagnosis of clubfoot: a six-year experience. (8834190)
1996
50
Esophageal atresia, coloboma, and clubfoot in two unrelated infants. (6469248)
1984

Genetic Variations for Clubfoot

About this section

Expression for genes affiliated with Clubfoot

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Clubfoot

Search GEO for disease gene expression data for Clubfoot.

Pathways for genes affiliated with Clubfoot

About this section

Compounds for genes affiliated with Clubfoot

About this section

GO Terms for genes affiliated with Clubfoot

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Clubfoot according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell developmentGO:01072010.6HOXD11, HOXA11
2cartilage development involved in endochondral bone morphogenesisGO:06035110.6HOXD11, HOXA11
3hindlimb morphogenesisGO:03513710.5HOXD9, HOXD10, GDF5
4forelimb morphogenesisGO:03513610.5GDF5, HOXD10
5positive regulation of chondrocyte differentiationGO:03233210.5GDF5, HOXA11, HOXD11
6peripheral nervous system neuron developmentGO:04893510.5HOXD10, HOXD9
7embryonic limb morphogenesisGO:03032610.5TBX4, GDF5, HOXA11, HOXD10
8dorsal/ventral pattern formationGO:00995310.5HOXD11, HOXA2, HOXA11
9embryonic skeletal joint morphogenesisGO:06027210.5HOXD11, HOXA11
10cartilage developmentGO:05121610.5PITX1, GDF5, HOXD3, TGFBR2
11embryonic forelimb morphogenesisGO:03511510.5HOXA11, HOXD11, HOXD9
12organ inductionGO:00175910.5HOXA11, HOXD11
13embryonic digit morphogenesisGO:04273310.5HOXA11, HOXD11, HOXD12
14proximal/distal pattern formationGO:00995410.5HOXA11, HOXD10, HOXD11, HOXD9
15embryonic skeletal system morphogenesisGO:04870410.5HOXA5, HOXD9, HOXD10, HOXD3
16thyroid gland developmentGO:03087810.4HOXA5, HOXD3
17skeletal system morphogenesisGO:04870510.3HOXD8, TBX4
18skeletal system developmentGO:00150110.3PITX1, HOXA11, HOXD12
19metanephros developmentGO:00165610.3HOXD11, HOXA11
20anterior/posterior pattern specificationGO:00995210.2HOXA5, HOXA11, HOXD3, HOXA2, HOXD10, HOXD11
21developmental growthGO:04858910.2HOXD11, HOXA11
22positive regulation of transcription from RNA polymerase II promoterGO:04594410.2HOXA5, HOXD9, HOXD10, HOXA2, PITX1
23multicellular organismal developmentGO:0072759.9TBX4, HOXA11, HOXD4, HOXD12
24transcription, DNA-dependentGO:0063519.7PITX1, TBX4, HOXD8, HOXA11, HOXD3, HOXA2

Molecular functions related to Clubfoot according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:0037009.4HOXA2, HOXD3, HOXA11, HOXD8, TBX4, HOXD10
2sequence-specific DNA bindingGO:0435659.1HOXA5, PITX1, HOXD8, HOXA11, HOXD3, HOXA2

Products for genes affiliated with Clubfoot

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Clubfoot

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet