MCID: CLB002
MIFTS: 42

Clubfoot malady

Genetic diseases, Bone diseases, Fetal diseases, Rare diseases categories

Aliases & Classifications for Clubfoot

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 36MeSH, 29ICD9CM, 59SNOMED-CT, 65UMLS, 42NCIt
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Aliases & Descriptions for Clubfoot:

Name: Clubfoot 10 47 12 36
Congenital Talipes Equinovarus 10
Equinovarus Deformity of Foot 10
 
Congenital Equinovarus 10
Congenital Clubfoot 10
Club Foot 47


Classifications:



Summaries for Clubfoot

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Disease Ontology:10 A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.

MalaCards based summary: Clubfoot, also known as congenital talipes equinovarus, is related to arthrogryposis, distal, type 3 and talipes equinovarus. An important gene associated with Clubfoot is PITX1 (Paired-Like Homeodomain 1), and among its related pathways is Striated Muscle Contraction. Affiliated tissues include bone, skin and skeletal muscle, and related mouse phenotypes are limbs/digits/tail and muscle.

Wikipedia:68 Club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

Related Diseases for Clubfoot

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Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot Familial Clubfoot Due to Pitx1 Point Mutation

Diseases related to Clubfoot via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1arthrogryposis, distal, type 330.4TNNT3, TPM2
2talipes equinovarus10.7
3clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.5
4familial clubfoot with or without associated lower limb anomalies10.3
5ehlers-danlos syndrome, musculocontractural type10.3
6short stature robin sequence cleft mandible hand anomalies clubfoot10.3
7familial clubfoot due to 17q23.1q23.2 microduplication10.3
8familial clubfoot due to pitx1 point mutation10.3
9familial clubfoot due to 5q31 microdeletion10.3
10myotonic dystrophy10.2
11arthrogryposis multiplex congenita, distal, type 110.2
12spondyloepiphyseal dysplasia with congenital joint dislocations10.2
13robin sequence with cleft mandible and limb anomalies10.2
14tarp syndrome10.2
15myelomeningocele10.2
16pitx1-related congenital clubfoot10.2
17arthrogryposis, distal, type 5d10.1
18pseudohypoaldosteronism, type iie10.1
19diastrophic dysplasia10.1
20atelosteogenesis ii10.1
21epiphyseal dysplasia, multiple, 410.1
22smed strudwick type10.1
23moebius syndrome10.1
24loeys-dietz syndrome 510.1
25ehlers-danlos syndrome, musculocontractural type 110.1
26congenital nervous system abnormality10.1
27ehlers-danlos syndrome10.1
28neuromuscular disease10.1
2946,xy disorder of sex development - adrenal insufficiency due to cyp11a1 deficiency10.1TNNT3, TPM2
30neuropathy, hereditary sensory and autonomic, type v10.1
31peters anomaly10.1
32multiple epiphyseal dysplasia10.1
33neuronitis10.1
34dysostosis10.1
35adducted thumbs dundar type10.1
36phace syndrome10.1
37radial defect robin sequence10.1
38constriction rings syndrome10.1
39hypertensive heart disease10.0ECEL1, TNNT3
40tonsil cancer10.0ECEL1, TNNT3
41vertical talus, congenital10.0
42spondylocarpotarsal synostosis syndrome10.0
43larsen syndrome10.0
44bruck syndrome 210.0
45tibial hemimelia10.0
46friedreich ataxia10.0
47orofaciodigital syndrome iv10.0
48spondyloperipheral dysplasia10.0
49arthrogryposis, distal, type 1b10.0
50epileptic encephalopathy, early infantile, 2910.0

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Symptoms for Clubfoot

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Drugs & Therapeutics for Clubfoot

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Drugs for Clubfoot (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Botulinum Toxins, Type APhase 4, Phase 3, Phase 2561
2Botulinum ToxinsPhase 3, Phase 2590
3HemagglutininsPhase 2106
4AstragalusNutraceutical43

Interventional clinical trials:

(show all 31)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic PatientsCompletedNCT00825097Phase 3
3Study of GSK1358820 In Patients With Post-Stroke Lower Limb SpasticityCompletedNCT00460655Phase 3
4Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral PalsyRecruitingNCT02188277Phase 2
5Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRICompletedNCT01088828
6Gait Analysis in Ponseti ClubfootCompletedNCT02022267
7Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)CompletedNCT00474344
8Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti MethodCompletedNCT01067651
9Outcomes of Compliance With Brace Wear in ClubfootCompletedNCT01481324
10A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot InfantsCompletedNCT02395185
11Treatment of Spastic Equinovarus Foot After StrokeCompletedNCT00199589
12Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootCompletedNCT01265238
13Impairments of Oral Language in Mobius SyndromeCompletedNCT00856531
14Clubfoot DNA RepositoryRecruitingNCT00607191
15Using Botox to Treat Patients With Idiopathic ClubfootRecruitingNCT00474032
16Pedobarographic Assessments of Clubfoot Treated PatientsRecruitingNCT00175708
17Prospective Evaluation of Treatment for ClubfootRecruitingNCT02257229
18Effectiveness of Parents' Manipulation in Newborn With Talipes CalcaneusRecruitingNCT01767662
19Instep Plantar Fasciotomy With and Without Gastrocnemius RecessionRecruitingNCT02287714
20Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar PressureRecruitingNCT02233140
21Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
22Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized TrialActive, not recruitingNCT01551264
23Efficacy of Botox in Patients With Idiopathic ClubfootActive, not recruitingNCT00152334
24A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic ClubfootActive, not recruitingNCT00152347
25Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
26Genetic Disease Gene IdentificationEnrolling by invitationNCT00916903
27Sucrose Analgesia in Infants Undergoing Casting for Club FootNot yet recruitingNCT01050088
28Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles TendonSuspendedNCT01382628
29Ankle Equinus Contracture Treated With Dynamic SplintingTerminatedNCT01238484
30The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon FracturesTerminatedNCT02051933
31Economic Evaluation of Clubfoot Treatment: One Centre's ExperienceWithdrawnNCT00475631

Search NIH Clinical Center for Clubfoot


Cochrane evidence based reviews: Clubfoot

Genetic Tests for Clubfoot

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Anatomical Context for Clubfoot

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MalaCards organs/tissues related to Clubfoot:

33
Bone, Skin, Skeletal muscle

Animal Models for Clubfoot or affiliated genes

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MGI Mouse Phenotypes related to Clubfoot:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.2CHST14, HOXD10, HOXD13, PITX1, SLC26A2, TBX4
2MP:00053698.2ECEL1, HOXD10, HOXD13, PITX1, TNNT3
3MP:00053907.4CHST14, ECEL1, HOXD10, HOXD13, PITX1, SLC26A2
4MP:00036316.9AARS, CHST14, CHST3, ECEL1, HOXD10, HOXD13

Publications for Clubfoot

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Articles related to Clubfoot:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Conservative treatment of severe clubfoot using a novel functional dynamic splint. (25438104)
2015
2
Initial Correction Predicts the Need for Secondary Achilles Tendon Procedures in Patients With Idiopathic Clubfoot Treated With Ponseti Casting. (25730291)
2015
3
Factors Associated With Increased Risk of Clubfoot: A Norwegian National Cohort Analysis. (26539903)
2015
4
The effect of clinical, radiographic and functional scores on the total score in the evaluation of congenital clubfoot. (25568547)
2014
5
Ponseti treatment for clubfoot in Romania: a 9-year single-centre experience. (25153646)
2014
6
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
7
Comment on Morin et al "Positive Communication Paradigm Decreases Early Recurrence in Clubfoot Treatment" (25122079)
2014
8
Is tibialis anterior tendon transfer effective for recurrent clubfoot? (24061847)
2014
9
Worldwide spread of the Ponseti method for clubfoot. (25405086)
2014
10
Classification of relapse pattern in clubfoot treated with Ponseti technique. (25298569)
2014
11
Idiopathic clubfoot: ten year follow-up after a soft tissue release procedure. (25231572)
2014
12
Propofol sedation for infants with idiopathic clubfoot undergoing percutaneous tendoachilles tenotomy. (23232381)
2013
13
Descriptive epidemiology of idiopathic clubfoot. (23686911)
2013
14
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
2012
15
Treatment results of late-relapsing idiopathic clubfoot previously treated with the Ponseti method. (22584843)
2012
16
Post clubfoot release skin necrosis: a preventable disaster. (21526037)
2011
17
The influence of brace type on the success rate of the Ponseti treatment protocol for idiopathic clubfoot. (22468155)
2011
18
Long-term results of the posteromedial release in the treatment of idiopathic clubfoot. (20864856)
2010
19
Clubfoot classification: correlation with Ponseti cast treatment. (20864855)
2010
20
Bracing following correction of idiopathic clubfoot using the Ponseti method. (20675641)
2010
21
Magnetic resonance angiography in clubfoot and vertical talus: a feasibility study. (19127394)
2009
22
CT study on the effect of different treatment protocols for clubfoot pathology. (19190974)
2009
23
Early results of the Ponseti method for the treatment of clubfoot associated with myelomeningocele. (19487512)
2009
24
Clubfoot: etiology and treatment Ignacio V. Ponseti, MD, 1914-. (19184257)
2009
25
Clubfoot treatment: Ponseti and French functional methods are equally effective. (19242767)
2009
26
Evaluation of the utility of the Ponseti method of correction of clubfoot deformity in a developing nation. (17115153)
2008
27
Clubfoot: etiology and treatment. (19823650)
2008
28
Results of manipulation of idiopathic clubfoot deformity in Malawi by orthopaedic clinical officers using the Ponseti method: a realistic alternative for the developing world? (18209628)
2007
29
Results of an accelerated Ponseti protocol for clubfoot. (16199943)
2005
30
Radical soft-tissue release of the arthrogrypotic clubfoot. (15703521)
2005
31
Bleeding complications following percutaneous tendoachilles tenotomy in the treatment of clubfoot deformity. (15205614)
2004
32
Validity of the anteroposterior talocalcaneal angle to assess congenital clubfoot correction. (15100132)
2004
33
The effect of the internet in the treatment of congenital idiopathic clubfoot. (14575256)
2003
34
Anthropometric study of patients treated for clubfoot. (12826950)
2003
35
Joint laxity and the risk of clubfoot. (14632308)
2003
36
The ponseti technique for correction of congenital clubfoot. (12377924)
2002
37
Regional fasciocutaneous flap closure for clubfoot surgery. (11176353)
2001
38
Anterior tibial tendon transfer in residual dynamic clubfoot deformity. (11176351)
2001
39
Ankle and first metatarsophalangeal joint dorsiflexion in children with clubfoot. (11675544)
2001
40
Comparison of the soft-tissue release methods in idiopathic clubfoot. (11008747)
2000
41
Surgical treatment of clubfoot: the significance of talocalcaneonavicular malposition correction. (10709589)
1999
42
Rotation fasciocutaneous flap for neglected clubfoot: a new technique. (9600556)
1998
43
Cases of congenital dislocation of the knee (CDK) not associated with clubfoot, arthrogryposis multiplex congenita, and Larsen's syndrome can be treated conservatively. (9531418)
1998
44
Long-term results of the operative treatment of clubfoot: a representative study. (9642705)
1998
45
Regional anesthesia for clubfoot surgery in children. (10099069)
1998
46
Muscle and tendon size relationships in a paralyzed chick embryo model of clubfoot. (9600555)
1998
47
A personal revolution in the development of clubfoot correction. (9030444)
1997
48
Controversies in the surgical management of clubfoot. (8727753)
1996
49
Treatment of idiopathic clubfoot. A thirty-year follow-up note. (8876592)
1996
50
Esophageal atresia, coloboma, and clubfoot in two unrelated infants. (6469248)
1984

Variations for Clubfoot

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Expression for genes affiliated with Clubfoot

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Search GEO for disease gene expression data for Clubfoot.

Pathways for genes affiliated with Clubfoot

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Pathways related to Clubfoot according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.8MYBPC1, MYH3, TNNT3, TPM2

GO Terms for genes affiliated with Clubfoot

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Cellular components related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:00329829.5MYBPC1, MYH3

Biological processes related to Clubfoot according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of ATPase activityGO:004346210.3TNNT3, TPM2
2hindlimb morphogenesisGO:003513710.2HOXD10, PITX1
3skeletal muscle contractionGO:000300910.1MYH3, TNNT3
4neuromuscular processGO:00509059.9AARS, HOXD10
5chondroitin sulfate metabolic processGO:00302049.8CHST14, CHST3
6limb morphogenesisGO:00351089.6HOXD13, TBX4
7glycosaminoglycan metabolic processGO:00302039.6CHST14, CHST3, SLC26A2
8embryonic limb morphogenesisGO:00303269.1HOXD10, HOXD13, MYH3, TBX4
9skeletal system developmentGO:00015019.0HOXD10, HOXD13, PITX1
10muscle filament slidingGO:00300498.8MYBPC1, MYH3, TNNT3, TPM2

Molecular functions related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:00083079.6MYBPC1, TPM2
2sulfotransferase activityGO:00081469.4CHST14, CHST3

Sources for Clubfoot

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet