MCID: CLB002
MIFTS: 46

Clubfoot malady

Summaries for Clubfoot

Sources:
64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 A club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

MalaCards: Clubfoot, also known as congenital talipes equinovarus, is related to polydactyly and talipes equinovarus. An important gene associated with Clubfoot is CHST14 (carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14). Affiliated tissues include skeletal muscle and skin, and related mouse phenotypes are craniofacial and digestive/alimentary.

Description from OMIM:47 119800

Aliases & Classifications for Clubfoot

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 47OMIM, 27ICD9CM
See all sources

Aliases & Descriptions:

clubfoot 8 10 45
congenital talipes equinovarus 8
equinovarus deformity of foot 8
congenital equinovarus 8
congenital clubfoot 8
club foot 45


Related Diseases for Clubfoot

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Clubfoot family:

familial clubfoot due to 17q23.1q23.2 microduplication familial clubfoot due to 5q31 microdeletion

Diseases related to Clubfoot via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly30.1HOXD11, HOXD12
2talipes equinovarus10.5
3clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.3
4adducted thumb and clubfoot syndrome10.3
5kabuki syndrome10.3
6congenital myotonic dystrophy10.3
7ehlers–danlos syndrome10.2
8short stature robin sequence cleft mandible hand anomalies clubfoot10.2
9familial clubfoot due to 17q23.1q23.2 microduplication10.2
10pseudohypoaldosteronism type ii10.1
11richieri costa pereira syndrome10.1
12familial clubfoot due to 5q31 microdeletion10.1
13multiple epiphyseal dysplasia10.1
14nager acrofacial dysostosis10.1
15adducted thumbs dundar type10.1
16radial defect robin sequence10.1
17phace syndrome10.1
18thumb deformity10.1
19spondyloepiphyseal dysplasia with congenital joint dislocations10.0
20cleft palate10.0
21atelosteogenesis type 210.0
22moebius syndrome10.0
23arthrogryposis multiplex congenita distal type 110.0
24myelomeningocele10.0
25metatarsus adductus10.0
26tarp syndrome10.0
27ehlers-danlos syndrome, musculocontractural type10.0
28pitx1-related congenital clubfoot10.0
29ehlers-danlos syndrome, musculocontractural type 210.0
30brachydactyly10.0GDF5
31syndactyly10.0HOXD1, HOXD12, GDF5
32vacterl association10.0HOXA5, HOXD3
33synostosis10.0HOXA11
34radioulnar synostosis10.0HOXA11, TBX4
35diastrophic dysplasia9.9
36larsen syndrome9.9
37friedreich ataxia9.9
38coloboma9.9
39gastroschisis9.9
40central core myopathy9.9
41distal arthrogryposis9.9
42osteoarthritis9.9
43situs inversus9.9
44esophageal atresia9.9
45imperforate anus9.9
46spondyloepimetaphyseal dysplasia, strudwick type9.9
47down syndrome9.9
48n syndrome9.9
49spina bifida9.9
50congenital fiber-type disproportion9.9

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Clinical Features for Clubfoot

Sources:
47OMIM
See all sources

Clinical features from OMIM:

119800

Drugs & Therapeutics for Clubfoot

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Clubfoot

Drug clinical trials:

Search ClinicalTrials for Clubfoot

Search NIH Clinical Center for Clubfoot

Search CenterWatch for Clubfoot

Genetic Tests for Clubfoot

Anatomical Context for Clubfoot

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Clubfoot:

33
Skeletal muscle, Skin

Animal Models for Clubfoot or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Clubfoot

Sources:
51PubMed
See all sources

Articles related to Clubfoot:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Results of Clubfoot Management Using the Ponseti Method: Do the Details Matter? A Systematic Review. (24435715)
2014
2
Ponseti method for late presentation of clubfoot. (24126499)
2014
3
The overcorrected clubfoot in the adult: evaluation and management--topical review. (23863312)
2013
4
Ilizarov in relapsed clubfoot: a necessary evil? (24060857)
2013
5
Evaluation of cast creep occurring during simulated clubfoot correction. (23636764)
2013
6
Conservative treatment of clubfoot using modified Copenhagen method. (22207468)
2012
7
Multiple tenotomies after Ponseti method for management of severe rigid clubfoot. (22112303)
2012
8
Re-assigned diagnosis of D4ST1-deficient Ehlers-Danlos syndrome (adducted thumb-clubfoot syndrome) after initial diagnosis of Marden-Walker syndrome. (22987394)
2012
9
Follow up of complete subtalar release for clubfoot--Evolution of different scores. (22326006)
2012
10
A comparison of ankle foot orthoses with foot abduction orthoses to prevent recurrence following correction of idiopathic clubfoot by the Ponseti method. (21511939)
2011
11
A 14-year longitudinal comparison study of two treatment methods in clubfoot: Ponseti versus traditional. (21954763)
2011
12
Mid-term results of Ponseti method for the treatment of congenital idiopathic clubfoot--(a study of 67 clubfeet with mean five year follow-up). (21226940)
2011
13
Tarsal decancellation in the residual resistant arthrogrypotic clubfoot. (21054925)
2011
14
Onset of developmental dysplasia of the hip during clubfoot treatment: report of two cases and review of patients with both deformities followed at a single institution. (21301366)
2011
15
Vascular abnormalities correlate with decreased soft tissue volumes in idiopathic clubfoot. (21042891)
2011
16
Ponseti's manipulation in neglected clubfoot in children more than 7 years of age: a prospective evaluation of 25 feet with long-term follow-up. (20581694)
2010
17
Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot. (19900178)
2010
18
Outcome of prenatally diagnosed isolated clubfoot. (20069547)
2010
19
Leg muscle atrophy in idiopathic congenital clubfoot: is it primitive or acquired? (19418086)
2009
20
Clubfoot: etiology and treatment: editorial comment. (19241114)
2009
21
Growth and development of tarsal and metatarsal bones in successfully treated congenital idiopathic clubfoot: early radiographic study. (19020469)
2009
22
What proportion of patients need extensive surgery after failure of the Ponseti technique for clubfoot? (19184263)
2009
23
Correction of arthrogrypotic clubfoot with a modified Ponseti technique. (19142694)
2009
24
Quantitative evaluation in vivo of the degree of differentiation of hindlimb cartilage in a rat clubfoot model. (19778219)
2009
25
Evaluation of the utility of the Ponseti method of correction of clubfoot deformity in a developing nation. (17115153)
2008
26
HOXD13 may play a role in idiopathic congenital clubfoot by regulating the expression of FHL1. (18758158)
2008
27
Congenital clubfoot with concomitant peroneal nerve palsy in children. (18510165)
2008
28
Review of current methods used in the treatment of clubfoot at initial presentation and at recurrence. (18549743)
2008
29
Results of manipulation of idiopathic clubfoot deformity in Malawi by orthopaedic clinical officers using the Ponseti method: a realistic alternative for the developing world? (18209628)
2007
30
The contralateral foot in children with unilateral clubfoot: a study of pressures and forces involved in gait. (17195799)
2007
31
Treatment of late recurring idiopathic clubfoot deformity in adults. (18019922)
2007
32
Focused dynamic sonographic examination of the congenital clubfoot. (17846756)
2007
33
Age-dependent dynamic sonographic measurement of pediatric clubfoot. (17846755)
2007
34
Continuous passive motion after surgery in infants with clubfoot led to greater short-term but not long-term improvement relative to standard immobilization. (16651605)
2006
35
Treatment of idiopathic clubfoot utilizing botulinum A toxin: a new method and its short-term outcomes. (15718908)
2005
36
Early experience with the Ponseti method for the treatment of congenital idiopathic clubfoot. (15909463)
2005
37
Centrally adaptations in unilateral idiopathic clubfoot children following conservative treatment. (15642655)
2005
38
The effect of the internet in the treatment of congenital idiopathic clubfoot. (14575256)
2003
39
Pulsed color-flow Doppler analysis of arterial deficiency in idiopathic clubfoot. (12499950)
2003
40
Clubfoot salvage: a review of the past decade's contributions. (12724612)
2003
41
Comparison of posteromedial and subtalar release in surgical treatment of resistant clubfoot. (12046913)
2002
42
Ankle and first metatarsophalangeal joint dorsiflexion in children with clubfoot. (11675544)
2001
43
Posterolateral release for idiopathic clubfoot: review of 18 patients. (11324675)
2001
44
Magnetic resonance imaging in follow-up of treated clubfoot during childhood. (11223479)
2001
45
Comparison of the soft-tissue release methods in idiopathic clubfoot. (11008747)
2000
46
Muscle and tendon size relationships in a paralyzed chick embryo model of clubfoot. (9600555)
1998
47
Correction of the talar neck angle in congenital clubfoot with sequential manipulation and casting. (9807711)
1998
48
Management of clubfoot deformity in amyoplasia. (9591987)
1997
49
Congenital clubfoot. (8686478)
1996
50
HLA and clubfoot (idiopathic talipes equinovarus). (7071822)
1982

Genetic Variations for Clubfoot

Expression for genes affiliated with Clubfoot

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Clubfoot

Search GEO for disease gene expression data for Clubfoot.

Pathways for genes affiliated with Clubfoot

Compounds for genes affiliated with Clubfoot

GO Terms for genes affiliated with Clubfoot

Sources:
16Gene Ontology
See all sources

Biological processes related to Clubfoot according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell developmentGO:01072010.6HOXD11, HOXA11
2cartilage development involved in endochondral bone morphogenesisGO:06035110.6HOXD11, HOXA11
3hindlimb morphogenesisGO:03513710.5HOXD9, HOXD10, GDF5
4forelimb morphogenesisGO:03513610.5GDF5, HOXD10
5positive regulation of chondrocyte differentiationGO:03233210.5GDF5, HOXA11, HOXD11
6peripheral nervous system neuron developmentGO:04893510.5HOXD10, HOXD9
7embryonic limb morphogenesisGO:03032610.5TBX4, GDF5, HOXA11, HOXD10
8dorsal/ventral pattern formationGO:00995310.5HOXD11, HOXA2, HOXA11
9embryonic skeletal joint morphogenesisGO:06027210.5HOXD11, HOXA11
10cartilage developmentGO:05121610.5PITX1, GDF5, HOXD3, TGFBR2
11embryonic forelimb morphogenesisGO:03511510.5HOXA11, HOXD11, HOXD9
12organ inductionGO:00175910.5HOXA11, HOXD11
13embryonic digit morphogenesisGO:04273310.5HOXA11, HOXD11, HOXD12
14proximal/distal pattern formationGO:00995410.5HOXA11, HOXD10, HOXD11, HOXD9
15embryonic skeletal system morphogenesisGO:04870410.5HOXA5, HOXD9, HOXD10, HOXD3
16thyroid gland developmentGO:03087810.4HOXA5, HOXD3
17skeletal system morphogenesisGO:04870510.3HOXD8, TBX4
18skeletal system developmentGO:00150110.3PITX1, HOXA11, HOXD12
19metanephros developmentGO:00165610.3HOXD11, HOXA11
20anterior/posterior pattern specificationGO:00995210.2HOXA5, HOXA11, HOXD3, HOXA2, HOXD10, HOXD11
21developmental growthGO:04858910.2HOXD11, HOXA11
22positive regulation of transcription from RNA polymerase II promoterGO:04594410.2HOXA5, HOXD9, HOXD10, HOXA2, PITX1
23multicellular organismal developmentGO:0072759.9TBX4, HOXA11, HOXD4, HOXD12
24transcription, DNA-dependentGO:0063519.7PITX1, TBX4, HOXD8, HOXA11, HOXD3, HOXA2

Molecular functions related to Clubfoot according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:0037009.4PITX1, TBX4, HOXD1, HOXD12, HOXD4, HOXD9
2sequence-specific DNA bindingGO:0435659.1PITX1, HOXD1, HOXD12, HOXD4, HOXD9, HOXD11

Products for genes affiliated with Clubfoot

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Clubfoot

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet