Aliases & Classifications for Clubfoot

MalaCards integrated aliases for Clubfoot:

Name: Clubfoot 12 72 51 41 14
Congenital Clubfoot 12 36
Congenital Talipes Equinovarus 12
Equinovarus Deformity of Foot 12
Congenital Equinovarus 12
Club Foot 51

Classifications:



Summaries for Clubfoot

Disease Ontology : 12 A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.

MalaCards based summary : Clubfoot, also known as congenital clubfoot, is related to talipes equinovarus and arthrogryposis, distal, type 1a. An important gene associated with Clubfoot is PITX1 (Paired Like Homeodomain 1), and among its related pathways/superpathways are Cardiac conduction and Striated Muscle Contraction. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and skeletal muscle, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and limbs/digits/tail

Wikipedia : 72 Clubfoot is a birth defect where one or both feet are rotated inwards and downwards. The affected foot,... more...

Related Diseases for Clubfoot

Diseases related to Clubfoot via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 talipes equinovarus 32.1 HOXD13 PITX1
2 arthrogryposis, distal, type 1a 32.0 MYBPC1 TPM2
3 arthrogryposis, distal, type 5 31.1 MYH3 TNNT3 TPM2
4 distal arthrogryposis 28.9 ECEL1 MYBPC1 MYH3 TNNT3 TPM2
5 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 12.4
6 short stature robin sequence cleft mandible hand anomalies clubfoot 11.9
7 familial clubfoot with or without associated lower limb anomalies 11.9
8 musculocontractural ehlers-danlos syndrome 11.7
9 arthrogryposis, distal, type 3 11.6
10 robin sequence with cleft mandible and limb anomalies 11.6
11 tarp syndrome 11.6
12 ehlers-danlos syndrome, musculocontractural type, 1 11.5
13 moebius syndrome 11.1
14 spondyloepiphyseal dysplasia with congenital joint dislocations 11.0
15 spondyloepimetaphyseal dysplasia, strudwick type 11.0
16 epiphyseal dysplasia, multiple, 4 11.0
17 lambert syndrome 11.0
18 chromosome 17q23.1-q23.2 duplication syndrome 11.0
19 diastrophic dysplasia 10.9
20 atelosteogenesis, type ii 10.9
21 pseudodiastrophic dysplasia 10.9
22 genitopatellar syndrome 10.9
23 arthrogryposis, distal, type 5d 10.9
24 loeys-dietz syndrome 5 10.9
25 hydrocephalus-cleft palate-joint contractures syndrome 10.9
26 larsen syndrome 10.8
27 vertical talus, congenital 10.8
28 orofaciodigital syndrome iv 10.8
29 spondyloperipheral dysplasia 10.8
30 spondylocarpotarsal synostosis syndrome 10.8
31 bruck syndrome 2 10.8
32 arthrogryposis, distal, type 1b 10.8
33 epileptic encephalopathy, early infantile, 29 10.8
34 lethal congenital contracture syndrome 11 10.8
35 sillence syndrome 10.8
36 chromosome 17q23.1-q23.2 deletion syndrome 10.3 PITX1 TBX4
37 aging 10.3
38 arthrogryposis multiplex congenita, neurogenic, with myelin defect 10.2
39 fissured tongue 10.2 ECEL1 TNNT3
40 congenital contractures 10.1 CHST14 TNNT3
41 desbuquois dysplasia 10.1 CHST3 SLC26A2
42 cataract 32, multiple types 10.0
43 myelomeningocele 10.0
44 syndactyly, type v 10.0 HOXD10 HOXD13
45 brachydactyly-syndactyly syndrome 9.9 HOXD10 HOXD13
46 central core disease of muscle 9.9
47 cleft palate, isolated 9.9
48 constricting bands, congenital 9.9
49 episodic pain syndrome, familial, 1 9.9
50 ehlers-danlos syndrome 9.9

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to Clubfoot

Symptoms & Phenotypes for Clubfoot

GenomeRNAi Phenotypes related to Clubfoot according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 9.17 CHST14 ECEL1 HOXD13 SLC26A2 TBX4 TNNT3

MGI Mouse Phenotypes related to Clubfoot:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.56 CHST14 HOXC12 HOXD10 HOXD13 PITX1 SLC26A2
2 skeleton MP:0005390 9.28 CHST14 CHST3 ECEL1 HOXD10 HOXD13 PITX1

Drugs & Therapeutics for Clubfoot

Drugs for Clubfoot (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 4,Phase 3,Phase 2
3 Botulinum Toxins Phase 4,Phase 3,Phase 2
4 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2
5 Cholinergic Agents Phase 4,Phase 3,Phase 2
6 Neuromuscular Agents Phase 4,Phase 3,Phase 2
7 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
8 onabotulinumtoxinA Phase 4,Phase 3,Phase 2
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
10 incobotulinumtoxinA Phase 4,Phase 2
11 Anesthetics Phase 3
12 Pharmaceutical Solutions Phase 2
13 Hemagglutinins Phase 2
14
Menthol Approved 2216-51-5 16666
15 Neuroserpin
16 Analgesics
17 Calcium, Dietary
18 Astragalus Nutraceutical

Interventional clinical trials:

(show top 50) (show all 65)

# Name Status NCT ID Phase Drugs
1 Therapeutic Effects of Customized Insoles on Children With Flat Foot Unknown status NCT02414087 Phase 4
2 Effects of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus Foot Completed NCT03044080 Phase 4 IncobotulinumtoxinA;OnabotulinumtoxinA
3 Post Marketing Surveillance Study of Dysport Completed NCT00210431 Phase 4
4 Comparison Study of Biofoam Porous Metal Versus Allograft to Treat Adult Acquired Flatfoot Withdrawn NCT00949897 Phase 4
5 Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patients Completed NCT00825097 Phase 3 Botulinum toxin injection
6 Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity Completed NCT00460655 Phase 3 GSK1358820;Placebo
7 Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy Completed NCT02188277 Phase 2 Xeomin;Botox®
8 Sucrose Analgesia in Infants Undergoing Casting for Club Foot Unknown status NCT01050088
9 A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic Clubfoot Unknown status NCT00152347 Botox
10 Effectiveness of Parents' Manipulation in Newborn With Talipes Calcaneus Unknown status NCT01767662
11 Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar Pressure Unknown status NCT02233140
12 Genetic Disease Gene Identification Unknown status NCT00916903
13 Calcaneal Neck Lengthening Osteotomy With Artificial Bone Graft Unknown status NCT01645267
14 Calcaneal Neck Lengthening Osteotomy in Children With Artificial Bone Graft Unknown status NCT01618812
15 Clubfoot DNA Repository Completed NCT00607191
16 Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRI Completed NCT01088828
17 Gait Analysis in Ponseti Clubfoot Completed NCT02022267
18 Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot Completed NCT02815306
19 Outcomes of Compliance With Brace Wear in Clubfoot Completed NCT01481324
20 A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot Infants Completed NCT02395185
21 Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot) Completed NCT00474344
22 Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti Method Completed NCT01067651
23 Development of Child With Equinus Deformity Idiopathic Completed NCT03382028
24 Treatment of Spastic Equinovarus Foot After Stroke Completed NCT00199589 Botulinic toxin (Botox)
25 Efficiency of Botulinum Toxin Injection for Spastic Equinovarus Foot in Post Stroke Hemiparetic Patients Completed NCT03405948 Intra muscular injection of Botulinum toxin
26 Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus Foot Completed NCT01265238
27 Impairments of Oral Language in Mobius Syndrome Completed NCT00856531
28 Effectiveness of Subtalar Arthroereisis With Endorthesis for Pediatric Flexible Flat Foot Completed NCT03372642
29 Effects on Pes Planus Exercise Training Mixed With Play on Pre-school Children Completed NCT03151538
30 Cotton Sock in Pediatric Patients With Leg-foot Splint Completed NCT03040882
31 The Effects of 12-week Custom-made Orthotic Intervention on the Structure and Function of the Foot of Healthy Young Adults During Gait Termination Completed NCT02957812
32 Comparison of Two Different Insole Types in Painful Flexible Flatfoot Completed NCT02706327
33 Clinical Trial of the Effect of Functional Orthoses in Children With Flat Feet Completed NCT02633566
34 Arthroereisis Versus Lateral Column Lengthening in the Treatment of Planovalgus Feet Completed NCT02055495
35 Weightbearing Assessment of Tarsal Instability Completed NCT01868789
36 Polyurethane Foam on the Heel for Prevention in Children Completed NCT03039179
37 The Development of Flat Foot After Ankle Fractures Completed NCT00507910
38 The Outcome Effect of Shoe Lift for Individuals With Low Back Pain and Pronated Foot Due to Anatomical Leg Length Discrepancy Completed NCT01187693
39 Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and Clubfeet Recruiting NCT02755766
40 Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic Clubfoot Recruiting NCT02815215 Early Phase 1
41 Using Botox to Treat Patients With Idiopathic Clubfoot Recruiting NCT00474032 Botulinum Toxin (Type A) injection (10 U/Kg)
42 Prospective Evaluation of Treatment for Clubfoot Recruiting NCT02257229
43 Pedobarographic Assessments of Clubfoot Treated Patients Recruiting NCT00175708
44 Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral Palsy Recruiting NCT02814786
45 MiracleFeet Foot Abduction Brace Sensor Trial Recruiting NCT03249805
46 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503
47 Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus Foot Recruiting NCT02790346
48 Trial Readiness and Endpoint Assessment in Congenital Myotonic Dystrophy Recruiting NCT03059264
49 Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome Recruiting NCT01144741
50 Efficacy and Safety of Nerve Root Axial Decompression Surgery in The Treatment of Tethered Cord Syndrome Recruiting NCT03262844

Search NIH Clinical Center for Clubfoot

Cochrane evidence based reviews: clubfoot

Genetic Tests for Clubfoot

Anatomical Context for Clubfoot

MalaCards organs/tissues related to Clubfoot:

38
Bone, Skin, Skeletal Muscle

Publications for Clubfoot

Articles related to Clubfoot:

(show top 50) (show all 651)
# Title Authors Year
1
Radiographic Prognostic Factors for Selective Soft Tissue Release After Ponseti Failure in Young Pediatric Clubfoot Patients. ( 29448825 )
2018
2
Development of an orthosis for simultaneous three-dimensional correction of clubfoot deformity. ( 29232570 )
2018
3
Clubfoot: Limk1 hits a nerve. ( 29439137 )
2018
4
Descriptive Epidemiology of Congenital Clubfoot Deformity in Sri Lanka. ( 29394982 )
2018
5
The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse. ( 29439133 )
2018
6
Treatment of clubfoot with the modified Copenhagen method: A 10-year follow-up. ( 29153045 )
2017
7
Ponseti method in the management of clubfoot under 2 years of age: A systematic review. ( 28632733 )
2017
8
A prospective cohort study on comparison of early outcome of classical Ponseti and modified Ponseti post tenotomy in clubfoot management. ( 29123654 )
2017
9
Clubfoot and Tethered Cord Syndrome: Results of Treatment With the Ponseti Method. ( 28178095 )
2017
10
'Fast cast' and 'needle Tenotomy' protocols with the Ponseti method to improve clubfoot management in Bangladesh. ( 29151894 )
2017
11
History of clubfoot treatment; part III (twentieth century): back to the future. ( 28879606 )
2017
12
Ponseti Casting Method in Idiopathic Congenital Clubfoot and Its Correlation with Radiographic Features Abstract. ( 28656164 )
2017
13
Developing a Three-Dimensional (3D) Assessment Method for Clubfoot-A Study Protocol. ( 29354068 )
2017
14
Arterial tree anomalies in patients with clubfoot: an investigation carried out at Soba University Hospital. ( 28704304 )
2017
15
Prenatal Diagnosis of Clubfoot: A Review of Current Available Methodology. ( 28976907 )
2017
16
Interstitial deletion 5p14.1-p15.2 and 5q14.3-q23.2 in a patient with clubfoot, blepharophimosis, arthrogryposis, and multiple congenital abnormalities. ( 28815864 )
2017
17
Assessment of success of the Ponseti method of clubfoot management in sub-Saharan Africa: a systematic review. ( 29141609 )
2017
18
A Long-term Follow-up of Young Adults With Idiopathic Clubfoot: Does Foot Morphology Relate to Pain? ( 28777274 )
2017
19
Predictive value of Pirani scoring system for tenotomy in the management of idiopathic clubfoot. ( 28617179 )
2017
20
Clinico-sonographical evaluation of idiopathic clubfoot and its correction by Ponseti method - A prospective study. ( 29126047 )
2017
21
Early radiographic risk factors for rigid relapse in idiopathic clubfoot treated with the Ponseti method. ( 29409275 )
2017
22
COMPARISON BETWEEN TWO TYPES OF ABDUCTION ORTHOTICS IN TREATING CONGENITAL CLUBFOOT. ( 28955166 )
2017
23
Flatfoot in the contralateral foot in patients with unilateral idiopathic clubfoot treated using the foot abduction brace. ( 28858119 )
2017
24
The quality of Achilles tendon repair five to eight years after percutaneous tenotomy in the treatment of clubfoot: clinical and ultrasonographic findings. ( 28053270 )
2017
25
The Timing and Relevance of Relapsed Deformity in Patients With Idiopathic Clubfoot. ( 28574943 )
2017
26
What is a good result after clubfoot treatment? A Delphi-based consensus on success by regional clubfoot trainers from across Africa. ( 29267350 )
2017
27
Comparison of different conservative treatments for idiopathic clubfoot: Ponseti's versus non-Ponseti's methods. ( 28553760 )
2017
28
Diagnostic accuracy, work-up, and outcomes of pregnancies with clubfoot detected by prenatal sonography. ( 28568170 )
2017
29
Ponseti method treatment of neglected idiopathic clubfoot: Preliminary results of a multi-center study in Nigeria. ( 28875128 )
2017
30
Significance Of Pirani Score at Bracing-Implications for Recognizing A Corrected Clubfoot. ( 28852350 )
2017
31
Clubfoot relapse: does presentation differ based on age at initial relapse? ( 29081851 )
2017
32
Genetics of clubfoot; recent progress and future perspectives. ( 28919208 )
2017
33
History of clubfoot treatment, part I: From manipulation in antiquity to splint and plaster in Renaissance before tenotomy. ( 28447124 )
2017
34
Ponseti method is superior to surgical treatment in clubfoot - Long-term, randomized, prospective trial. ( 28866453 )
2017
35
Evertor muscle activity as a predictor for recurrence in idiopathic clubfoot. ( 28528482 )
2017
36
Age of Recurrence in Idiopathic Clubfoot Treated with the Ponseti Method. ( 28902604 )
2017
37
Evolution of clubfoot deformity and muscle abnormality in the Ponseti method: evaluation with the Dimeglio score. ( 27349648 )
2016
38
Comparison of the Ponseti method versus early tibialis anterior tendon transfer for idiopathic clubfoot: A prospective randomized study. ( 27496186 )
2016
39
Tincture of Benzoin to Prevent Cast Slippage in Clubfoot. ( 28553455 )
2016
40
A mini-open technique for Achilles tenotomy in infants with clubfoot. ( 26825454 )
2016
41
What factors affect patient access and engagement with clubfoot treatment in low- and middle-income countries? Meta-synthesis of existing qualitative studies using a social ecological model. ( 26892686 )
2016
42
Development of congenital clubfoot during growth: a long-term study on the basis of pedobarography, biomechanics, and magnetic resonance imaging measurements of muscle volumes. ( 26919619 )
2016
43
Ponseti Treatment of Rigid Residual Deformity in Congenital Clubfoot After Walking Age. ( 27869621 )
2016
44
How Many Patients Who Have a Clubfoot Treated Using the Ponseti Method are Likely to Undergo a Tendon Transfer? ( 27379785 )
2016
45
Ponseti treatment for idiopathic clubfoot deformity - Role of secondary care hospitals. ( 26712195 )
2016
46
Functional Assessment of Clubfoot Associated HOXA9, TPM1, and TPM2 Variants Suggests a Potential Gene Regulation Mechanism. ( 27020427 )
2016
47
Modified Lambrinudi Arthrodesis for the Acute Treatment of Neurogenic Clubfoot: A Case Report. ( 27920102 )
2016
48
Design and descriptive data of the randomized Clubfoot Foot Abduction Brace Length of Treatment Study (FAB24). ( 27632641 )
2016
49
What is new in idiopathic clubfoot? ( 27696325 )
2016
50
Association between maternal age at conception and risk of idiopathic clubfoot. ( 26901038 )
2016

Variations for Clubfoot

Expression for Clubfoot

Search GEO for disease gene expression data for Clubfoot.

Pathways for Clubfoot

GO Terms for Clubfoot

Cellular components related to Clubfoot according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 9.16 MYBPC1 MYH3
2 muscle myosin complex GO:0005859 8.96 MYBPC1 MYH3
3 myosin filament GO:0032982 8.62 MYBPC1 MYH3

Biological processes related to Clubfoot according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.85 HOXC12 HOXD10 HOXD13 PITX1 TBX4
2 skeletal system development GO:0001501 9.54 HOXD10 HOXD13 PITX1
3 sarcomere organization GO:0045214 9.43 MYBPC1 MYH3
4 limb morphogenesis GO:0035108 9.4 HOXD13 TBX4
5 skeletal muscle contraction GO:0003009 9.32 MYH3 TNNT3
6 hindlimb morphogenesis GO:0035137 9.26 HOXD10 PITX1
7 embryonic limb morphogenesis GO:0030326 9.26 HOXD10 HOXD13 MYH3 TBX4
8 regulation of ATPase activity GO:0043462 9.16 TNNT3 TPM2
9 muscle filament sliding GO:0030049 8.92 MYBPC1 MYH3 TNNT3 TPM2

Molecular functions related to Clubfoot according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sulfotransferase activity GO:0008146 9.26 CHST14 CHST3
2 sequence-specific DNA binding GO:0043565 9.26 HOXC12 HOXD10 HOXD13 PITX1
3 structural constituent of muscle GO:0008307 9.16 MYBPC1 TPM2
4 actin filament binding GO:0051015 8.8 MYBPC1 MYH3 TPM2

Sources for Clubfoot

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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