MCID: CLB002
MIFTS: 50

Clubfoot malady

Genetic diseases, Bone diseases, Fetal diseases, Rare diseases categories
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Summaries for Clubfoot

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Wikipedia:65 Club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

MalaCards based summary: Clubfoot, also known as congenital talipes equinovarus, is related to talipes equinovarus and adducted thumb and clubfoot syndrome. An important gene associated with Clubfoot is CHST14 (carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14), and among its related pathways is Transcriptional misregulation in cancer. The compounds gnrh and sulfate have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and skin, and related mouse phenotypes are cardiovascular system and limbs/digits/tail.

Description from OMIM:46 119800

Aliases & Classifications for Clubfoot

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 57SNOMED-CT, 34MeSH, 39NCIt, 62UMLS, 46OMIM, 27ICD9CM
See all sources

Clubfoot, Aliases & Descriptions:

Name: Clubfoot 8 10 44
Congenital Talipes Equinovarus 8
Equinovarus Deformity of Foot 8
 
Congenital Equinovarus 8
Congenital Clubfoot 8
Club Foot 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Fetal diseases, Rare diseases
Anatomical: Bone diseases


Related Diseases for Clubfoot

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Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot Familial Clubfoot Due to 17q23.1q23.2 Microduplication
Familial Clubfoot Due to 5q31 Microdeletion

Diseases related to Clubfoot via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1talipes equinovarus10.5
2adducted thumb and clubfoot syndrome10.4
3clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.4
4hemangioma10.3
5myotonic dystrophy type 210.3
6myotonic dystrophy10.3
7kabuki syndrome10.3
8familial clubfoot due to 17q23.1q23.2 microduplication10.2
9pseudohypoaldosteronism type ii10.2
10multiple epiphyseal dysplasia 410.2
11richieri costa pereira syndrome10.2
12short stature robin sequence cleft mandible hand anomalies clubfoot10.2
13familial clubfoot due to 5q31 microdeletion10.2
14multiple epiphyseal dysplasia10.1
15neuronitis10.1
16dysostosis10.1
17adducted thumbs dundar type10.1
18phace syndrome10.1
19radial defect robin sequence10.1
20constriction rings syndrome10.1
21cleft palate10.1
22spondyloepiphyseal dysplasia with congenital joint dislocations10.1
23ehlers-danlos syndrome10.1
24atelosteogenesis type 210.1
25arthrogryposis multiplex congenita distal type 110.1
26metatarsus adductus10.1
27moebius syndrome10.1
28myelomeningocele10.1
29tarp syndrome10.1
30pitx1-related congenital clubfoot10.1
31ehlers-danlos syndrome, musculocontractural type 110.1
32radioulnar synostosis10.0HOXA11, TBX4
33osteoporosis10.0SLC26A2, TGFBR2
34osteoarthritis9.9
35spina bifida9.9
36larsen syndrome9.9
37diastrophic dysplasia9.9
38polydactyly9.9
39situs inversus9.9
40friedreich ataxia9.9
41coloboma9.9
42distal arthrogryposis9.9
43spondyloepimetaphyseal dysplasia, strudwick type9.9
44esophageal atresia9.9
45imperforate anus9.9
46cerebritis9.9
47gastroschisis9.9
48esophagitis9.9
49myopathy9.9
50neuromuscular disease9.9

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Symptoms for Clubfoot

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Clinical features from OMIM:

119800

Drugs & Therapeutics for Clubfoot

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Drug clinical trials:

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Search NIH Clinical Center for Clubfoot

Genetic Tests for Clubfoot

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Anatomical Context for Clubfoot

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MalaCards organs/tissues related to Clubfoot:

32
Bone, Skeletal muscle, Skin

Animal Models for Clubfoot or affiliated genes

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MGI Mouse Phenotypes related to Clubfoot:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.7TBX4, CHST14, TGFBR2, PITX1
2MP:00053718.4HOXA11, PITX1, CHST14, TBX4, SLC26A2
3MP:00053848.0HOXA11, TGFBR2, CHST14, TBX4, SLC26A2
4MP:00053827.9HOXD4, PITX1, TGFBR2, CHST14, SLC26A2
5MP:00053787.5HOXD4, PITX1, TGFBR2, CHST14, SLC26A2
6MP:00053907.0SLC26A2, TBX4, CHST14, TGFBR2, PITX1, HOXD4
7MP:00107686.9HOXA11, HOXD4, PITX1, TGFBR2, CHST14, TBX4

Publications for Clubfoot

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Articles related to Clubfoot:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Ponseti treatment for clubfoot in Romania: a 9-year single-centre experience. (25153646)
2014
2
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
3
Comment on Morin et al "Positive Communication Paradigm Decreases Early Recurrence in Clubfoot Treatment" (25122079)
2014
4
Is tibialis anterior tendon transfer effective for recurrent clubfoot? (24061847)
2014
5
Worldwide spread of the Ponseti method for clubfoot. (25405086)
2014
6
Classification of relapse pattern in clubfoot treated with Ponseti technique. (25298569)
2014
7
Idiopathic clubfoot: ten year follow-up after a soft tissue release procedure. (25231572)
2014
8
Inter-rater reliability of physiotherapists using the Pirani scoring system for clubfoot: comparison with a modified five-point scale. (25144882)
2014
9
Propofol sedation for infants with idiopathic clubfoot undergoing percutaneous tendoachilles tenotomy. (23232381)
2013
10
Descriptive epidemiology of idiopathic clubfoot. (23686911)
2013
11
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
2012
12
Treatment results of late-relapsing idiopathic clubfoot previously treated with the Ponseti method. (22584843)
2012
13
Post clubfoot release skin necrosis: a preventable disaster. (21526037)
2011
14
The influence of brace type on the success rate of the Ponseti treatment protocol for idiopathic clubfoot. (22468155)
2011
15
Application of the Ponseti principle for deformity correction in neglected and relapsed clubfoot using the Ilizarov fixator. (20842065)
2011
16
Long-term results of the posteromedial release in the treatment of idiopathic clubfoot. (20864856)
2010
17
Clubfoot classification: correlation with Ponseti cast treatment. (20864855)
2010
18
Bracing following correction of idiopathic clubfoot using the Ponseti method. (20675641)
2010
19
Magnetic resonance angiography in clubfoot and vertical talus: a feasibility study. (19127394)
2009
20
CT study on the effect of different treatment protocols for clubfoot pathology. (19190974)
2009
21
Early results of the Ponseti method for the treatment of clubfoot associated with myelomeningocele. (19487512)
2009
22
Clubfoot: etiology and treatment Ignacio V. Ponseti, MD, 1914-. (19184257)
2009
23
Clubfoot treatment: Ponseti and French functional methods are equally effective. (19242767)
2009
24
Loss of dermatan-4-sulfotransferase 1 function results in adducted thumb-clubfoot syndrome. (20004762)
2009
25
Evaluation of the utility of the Ponseti method of correction of clubfoot deformity in a developing nation. (17115153)
2008
26
Clubfoot: etiology and treatment. (19823650)
2008
27
Results of manipulation of idiopathic clubfoot deformity in Malawi by orthopaedic clinical officers using the Ponseti method: a realistic alternative for the developing world? (18209628)
2007
28
Calcaneal derotation osteotomy for clubfoot revision surgery. (17414784)
2007
29
Results of an accelerated Ponseti protocol for clubfoot. (16199943)
2005
30
Radical soft-tissue release of the arthrogrypotic clubfoot. (15703521)
2005
31
Bleeding complications following percutaneous tendoachilles tenotomy in the treatment of clubfoot deformity. (15205614)
2004
32
Validity of the anteroposterior talocalcaneal angle to assess congenital clubfoot correction. (15100132)
2004
33
The effect of the internet in the treatment of congenital idiopathic clubfoot. (14575256)
2003
34
Anthropometric study of patients treated for clubfoot. (12826950)
2003
35
Joint laxity and the risk of clubfoot. (14632308)
2003
36
The ponseti technique for correction of congenital clubfoot. (12377924)
2002
37
Regional fasciocutaneous flap closure for clubfoot surgery. (11176353)
2001
38
Ankle and first metatarsophalangeal joint dorsiflexion in children with clubfoot. (11675544)
2001
39
Comparison of the soft-tissue release methods in idiopathic clubfoot. (11008747)
2000
40
Accurate determination of cast weight for neonates with clubfoot. (10739288)
2000
41
Postoperative blood loss into plaster casts after clubfoot surgery: an experimental model. (10218182)
1999
42
Surgical treatment of clubfoot: the significance of talocalcaneonavicular malposition correction. (10709589)
1999
43
Rotation fasciocutaneous flap for neglected clubfoot: a new technique. (9600556)
1998
44
Cases of congenital dislocation of the knee (CDK) not associated with clubfoot, arthrogryposis multiplex congenita, and Larsen's syndrome can be treated conservatively. (9531418)
1998
45
Long-term results of the operative treatment of clubfoot: a representative study. (9642705)
1998
46
Regional anesthesia for clubfoot surgery in children. (10099069)
1998
47
Muscle and tendon size relationships in a paralyzed chick embryo model of clubfoot. (9600555)
1998
48
A personal revolution in the development of clubfoot correction. (9030444)
1997
49
Controversies in the surgical management of clubfoot. (8727753)
1996
50
Esophageal atresia, coloboma, and clubfoot in two unrelated infants. (6469248)
1984

Variations for Clubfoot

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Expression for genes affiliated with Clubfoot

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Expression patterns in normal tissues for genes affiliated with Clubfoot

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Pathways for genes affiliated with Clubfoot

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Pathways related to Clubfoot according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TGFBR2, HOXA11

Compounds for genes affiliated with Clubfoot

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Sources:
44Novoseek, 24HMDB
See all sources

Compounds related to Clubfoot according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gnrh449.5TGFBR2, PITX1
2sulfate44 2410.3SLC26A2, CHST14

GO Terms for genes affiliated with Clubfoot

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Cellular components related to Clubfoot according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.6PITX1, HOXA11

Biological processes related to Clubfoot according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic limb morphogenesisGO:0303269.7TBX4, HOXA11
2skeletal system developmentGO:0015019.6PITX1, HOXA11
3cartilage developmentGO:0512169.5PITX1, TGFBR2
4anatomical structure morphogenesisGO:0096539.5PITX1, HOXA11
5glycosaminoglycan metabolic processGO:0302039.3SLC26A2, CHST14
6multicellular organismal developmentGO:0072758.8TBX4, HOXD4, HOXA11

Molecular functions related to Clubfoot according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435658.8PITX1, HOXD4, HOXA11
2sequence-specific DNA binding transcription factor activityGO:0037008.0TBX4, PITX1, HOXD4, HOXA11

Products for genes affiliated with Clubfoot

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  • Antibodies
  • Proteins
  • Lysates

Sources for Clubfoot

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet