MCID: CLB002
MIFTS: 47

Clubfoot malady

Summaries for Clubfoot

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

MalaCards: Clubfoot, also known as congenital talipes equinovarus, is related to polydactyly and clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly. An important gene associated with Clubfoot is CHST14 (carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14). Affiliated tissues include bone, skeletal muscle and skin, and related mouse phenotypes are craniofacial and digestive/alimentary.

Description from OMIM:46 119800

Aliases & Classifications for Clubfoot

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM, 27ICD9CM
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Aliases & Descriptions:

clubfoot 8 10 44
congenital talipes equinovarus 8
equinovarus deformity of foot 8
congenital equinovarus 8
congenital clubfoot 8
club foot 44


Related Diseases for Clubfoot

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot Familial Clubfoot Due to 17q23.1q23.2 Microduplication
Familial Clubfoot Due to 5q31 Microdeletion

Diseases related to Clubfoot via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly30.0HOXD12, HOXD11
2clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.3
3adducted thumb and clubfoot syndrome10.3
4myotonic dystrophy type 210.2
5myotonic dystrophy10.2
6kabuki syndrome10.2
7familial clubfoot due to 17q23.1q23.2 microduplication10.2
8pseudohypoaldosteronism type ii10.1
9richieri costa pereira syndrome10.1
10short stature robin sequence cleft mandible hand anomalies clubfoot10.1
11familial clubfoot due to 5q31 microdeletion10.1
12multiple epiphyseal dysplasia10.0
13neuronitis10.0
14dysostosis10.0
15adducted thumbs dundar type10.0
16radial defect robin sequence10.0
17spondyloepiphyseal dysplasia with congenital joint dislocations10.0
18cleft palate10.0
19ehlers-danlos syndrome10.0
20atelosteogenesis type 210.0
21arthrogryposis multiplex congenita distal type 110.0
22talipes equinovarus10.0
23tarp syndrome10.0
24pitx1-related congenital clubfoot10.0
25ehlers-danlos syndrome, musculocontractural type 210.0
26brachydactyly10.0GDF5
27syndactyly10.0GDF5, HOXD12, HOXD1
28vacterl association10.0HOXA5, HOXD3
29synostosis10.0HOXA11
30radioulnar synostosis10.0HOXA11, TBX4
31diastrophic dysplasia9.9
32larsen syndrome9.9
33friedreich ataxia9.9
34coloboma9.9
35cerebritis9.9
36gastroschisis9.9
37central core myopathy9.9
38distal arthrogryposis9.9
39osteoarthritis9.9
40situs inversus9.9
41esophageal atresia9.9
42imperforate anus9.9
43spondyloepimetaphyseal dysplasia, strudwick type9.9
44esophagitis9.9
45myopathy9.9
46neuromuscular disease9.9
47oligohydramnios9.9
48spina bifida9.9
49congenital fiber-type disproportion9.9
50multiple epiphyseal dysplasia, recessive9.9

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Clinical Features for Clubfoot

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46OMIM
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Clinical features from OMIM:

119800

Drugs & Therapeutics for Clubfoot

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Clubfoot

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Anatomical Context for Clubfoot

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32MalaCards
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MalaCards organs/tissues related to Clubfoot:

32
Bone, Skeletal muscle, Skin

Animal Models for Clubfoot or affiliated genes

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36MGI
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Publications for Clubfoot

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50PubMed
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Articles related to Clubfoot:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Propofol sedation for infants with idiopathic clubfoot undergoing percutaneous tendoachilles tenotomy. (23232381)
2013
2
Descriptive epidemiology of idiopathic clubfoot. (23686911)
2013
3
Evaluation of online health information on clubfoot using the DISCERN tool. (24048196)
2013
4
Prevalence of developmental dysplasia of the hip in children with clubfoot. (24432085)
2013
5
Progression of idiopathic clubfoot correction using the Ponseti method. (21527859)
2012
6
Development of a surrogate biomodel for the investigation of clubfoot bracing. (22955544)
2012
7
Creep evaluation of (orthotic) cast materials during simulated clubfoot correction. (23366644)
2012
8
Comprehensive review of the functional outcome evaluation of clubfoot treatment: a preferred methodology. (22080298)
2012
9
The need for early treatment of clubfeet in peripheral hospitals in sub-Saharan Africa: a survey of clubfoot management in Zambia. (22337729)
2012
10
Persistent clubfoot deformity following treatment by the Ponseti method. (22134651)
2012
11
Ponseti Brasil: a national program to eradicate neglected clubfoot - preliminary results. (22096418)
2011
12
Short-term results of intensive physiotherapy in clubfoot deformity treated with the Ponseti method. (20831648)
2011
13
Ponseti management of clubfoot after walking age. (20626641)
2011
14
Understanding the educational needs for parents of children with clubfoot. (21799385)
2011
15
Incidence of clubfoot in Uganda. (21033551)
2010
16
Transfer of the tendon of tibialis anterior in relapsed congenital clubfoot: long-term results in 38 feet. (20130323)
2010
17
Ponseti clubfoot management: changing surgical trends in Nigeria. (21045965)
2010
18
Fetal MRI of clubfoot associated with myelomeningocele. (20490482)
2010
19
Patient-reported outcome at 62 to 67 years of age in 83 patients treated for congenital clubfoot. (19794166)
2009
20
The classic: observations on pathogenesis and treatment of congenital clubfoot. 1972. (19219518)
2009
21
Is it possible to treat recurrent clubfoot with the Ponseti technique after posteromedial release?: a preliminary study. (19190971)
2009
22
Ankle valgus and subtalar varus in treated clubfoot. (19857815)
2009
23
Clubfoot: etiology and treatment. (19823650)
2008
24
The posterior talofibular ligament: an anatomical study with clinical implication in clubfoot surgery. (18633563)
2008
25
Analytical radiography of clubfoot after tenotomy. (18724211)
2008
26
Foot pressure in clubfoot--the development of an objective assessment tool. (20307419)
2008
27
Maternal smoking and the risk for clubfoot in infants. (18022868)
2008
28
Dorsal bunion after clubfoot surgery: outcome of reverse Jones procedure. (17878791)
2007
29
A new dynamic foot abduction orthosis for clubfoot treatment. (17585260)
2007
30
"Different" approach in the operative treatment of congenital clubfoot and its results. (16796130)
2006
31
Stress radiography in the assessment of residual deformity in clubfoot following postero-medial soft tissue release. (16521015)
2006
32
Bensahel et al. and International Clubfoot Study Group evaluation of treated clubfoot: assessment of interobserver and intraobserver reliability. (16280717)
2006
33
A search for the gene(s) predisposing to idiopathic clubfoot. (15733275)
2005
34
Obstetrics. 22q11 deletion syndrome with truncus arteriosus, hypoplastic left ventricle, VSD, clubfoot, sandal toes, cleft palate, butterfly vertebrae. (15905821)
2005
35
Correction of relapsed or neglected clubfoot using a simple Ilizarov frame. (14762694)
2004
36
A method for the early evaluation of the Ponseti (Iowa) technique for the treatment of idiopathic clubfoot. (12584499)
2003
37
Long-term comparative results in patients with congenital clubfoot treated with two different protocols. (12851354)
2003
38
Late recurrence of clubfoot deformity: a 45-year followup. (12782875)
2003
39
Distal tibial transphyseal osteotomy for ankle varus deformity in an operated case of clubfoot. (14597789)
2003
40
The genetics of idiopathic clubfoot. (12151881)
2002
41
Ultrasound anatomy in the neonatal clubfoot. (12271392)
2002
42
Regional fasciocutaneous flap closure for clubfoot surgery. (11176353)
2001
43
Peritalar release in the treatment of congenital talipes equinovarus clubfoot. (12056243)
2001
44
Patient-based outcomes after clubfoot surgery. (11176352)
2001
45
Evaluation of the walking pattern in clubfoot patients who received early intensive treatment. (11008746)
2000
46
Rotation fasciocutaneous flap for neglected clubfoot: a new technique. (9600556)
1998
47
A personal revolution in the development of clubfoot correction. (9030444)
1997
48
Subtalar realignment in congenital clubfoot using the Cincinnati approach. (17008967)
1997
49
A comparison of the long-term results of posterior and comprehensive release in the treatment of clubfoot. (8989698)
1997
50
Critical aspects of neonatal surgery in clubfoot. (8744434)
1996

Genetic Variations for Clubfoot

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Expression for genes affiliated with Clubfoot

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Clubfoot

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Pathways for genes affiliated with Clubfoot

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Compounds for genes affiliated with Clubfoot

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GO Terms for genes affiliated with Clubfoot

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16Gene Ontology
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Biological processes related to Clubfoot according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell developmentGO:01072010.6HOXD11, HOXA11
2cartilage development involved in endochondral bone morphogenesisGO:06035110.6HOXD11, HOXA11
3hindlimb morphogenesisGO:03513710.5HOXD9, HOXD10, GDF5
4forelimb morphogenesisGO:03513610.5GDF5, HOXD10
5positive regulation of chondrocyte differentiationGO:03233210.5GDF5, HOXA11, HOXD11
6peripheral nervous system neuron developmentGO:04893510.5HOXD10, HOXD9
7embryonic limb morphogenesisGO:03032610.5TBX4, GDF5, HOXA11, HOXD10
8dorsal/ventral pattern formationGO:00995310.5HOXD11, HOXA2, HOXA11
9embryonic skeletal joint morphogenesisGO:06027210.5HOXD11, HOXA11
10cartilage developmentGO:05121610.5PITX1, GDF5, HOXD3, TGFBR2
11embryonic forelimb morphogenesisGO:03511510.5HOXA11, HOXD11, HOXD9
12organ inductionGO:00175910.5HOXA11, HOXD11
13embryonic digit morphogenesisGO:04273310.5HOXA11, HOXD11, HOXD12
14proximal/distal pattern formationGO:00995410.5HOXA11, HOXD10, HOXD11, HOXD9
15embryonic skeletal system morphogenesisGO:04870410.5HOXA5, HOXD9, HOXD10, HOXD3
16thyroid gland developmentGO:03087810.4HOXA5, HOXD3
17skeletal system morphogenesisGO:04870510.3HOXD8, TBX4
18skeletal system developmentGO:00150110.3PITX1, HOXA11, HOXD12
19metanephros developmentGO:00165610.3HOXD11, HOXA11
20anterior/posterior pattern specificationGO:00995210.2HOXA5, HOXA11, HOXD3, HOXA2, HOXD10, HOXD11
21developmental growthGO:04858910.2HOXD11, HOXA11
22positive regulation of transcription from RNA polymerase II promoterGO:04594410.2HOXA5, HOXD9, HOXD10, HOXA2, PITX1
23multicellular organismal developmentGO:0072759.9TBX4, HOXA11, HOXD4, HOXD12
24transcription, DNA-dependentGO:0063519.7PITX1, TBX4, HOXD8, HOXA11, HOXD3, HOXA2

Molecular functions related to Clubfoot according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:0037009.4PITX1, TBX4, HOXD1, HOXD12, HOXD4, HOXD9
2sequence-specific DNA bindingGO:0435659.1PITX1, HOXD1, HOXD12, HOXD4, HOXD9, HOXD11

Products for genes affiliated with Clubfoot

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Sources for Clubfoot

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet