MCID: CLB002
MIFTS: 41

Clubfoot malady

Genetic diseases, Bone diseases, Fetal diseases, Rare diseases categories

Aliases & Classifications for Clubfoot

About this section
Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 55SNOMED-CT, 60UMLS, 33MeSH, 38NCIt, 27ICD9CM
See all sources

Clubfoot, Aliases & Descriptions:

Name: Clubfoot 9 11 43
Congenital Talipes Equinovarus 9
Equinovarus Deformity of Foot 9
 
Congenital Equinovarus 9
Congenital Clubfoot 9
Club Foot 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Fetal diseases, Rare diseases
Anatomical: Bone diseases


Summaries for Clubfoot

About this section


Wikipedia:63 Club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

MalaCards based summary: Clubfoot, also known as congenital talipes equinovarus, is related to ehlers-danlos syndrome, musculocontractural type 1 and talipes equinovarus. An important gene associated with Clubfoot is CHST14 (carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14), and among its related pathways is Transcriptional misregulation in cancer. The compounds gnrh and sulfate have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and skin, and related mouse phenotypes are cardiovascular system and limbs/digits/tail.

Related Diseases for Clubfoot

About this section

Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot Familial Clubfoot Due to Pitx1 Point Mutation

Diseases related to Clubfoot via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1ehlers-danlos syndrome, musculocontractural type 110.6
2talipes equinovarus10.5
3clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.4
4robin sequence with cleft mandible and limb anomalies10.3
5pseudohypoaldosteronism, type iie10.2
6short stature robin sequence cleft mandible hand anomalies clubfoot10.2
7familial clubfoot due to 17q23.1q23.2 microduplication10.2
8familial clubfoot due to pitx1 point mutation10.2
9familial clubfoot due to 5q31 microdeletion10.2
10hemangioma10.2
11myotonic dystrophy10.2
12pitx1-related congenital clubfoot10.2
13familial clubfoot with or without associated lower limb anomalies10.2
14epiphyseal dysplasia, multiple, 410.1
15spondyloepiphyseal dysplasia with congenital joint dislocations10.1
16moebius syndrome10.1
17tarp syndrome10.1
18atelosteogenesis ii10.1
19arthrogryposis multiplex congenita, distal, type 110.1
20ehlers-danlos syndrome10.1
21myelomeningocele10.1
22peters anomaly10.1
23polyposis, juvenile intestinal10.1
24neuronitis10.1
25multiple epiphyseal dysplasia10.1
26dysostosis10.1
27adducted thumbs dundar type10.1
28phace syndrome10.1
29radial defect robin sequence10.1
30constriction rings syndrome10.1
31radioulnar synostosis10.0HOXA11, TBX4
32osteoporosis10.0TGFBR2, SLC26A2
33vertical talus, congenital9.9
34arthrogryposis, distal, type 5d9.9
35spondylocarpotarsal synostosis syndrome9.9
36larsen syndrome9.9
37diastrophic dysplasia9.9
38tibial hemimelia9.9
39orofaciodigital syndrome iv9.9
40spondyloperipheral dysplasia9.9
41potocki-lupski syndrome9.9
42marden-walker syndrome9.9
43friedreich ataxia9.9
44central core disease9.9
45smed strudwick type9.9
46osteoarthritis9.9
47polydactyly9.9
48situs inversus9.9
49esophageal atresia9.9
50imperforate anus9.9

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Symptoms for Clubfoot

About this section

Drugs & Therapeutics for Clubfoot

About this section

Drug clinical trials:

Search ClinicalTrials for Clubfoot

Search NIH Clinical Center for Clubfoot

Genetic Tests for Clubfoot

About this section

Anatomical Context for Clubfoot

About this section

MalaCards organs/tissues related to Clubfoot:

31
Bone, Skeletal muscle, Skin

Animal Models for Clubfoot or affiliated genes

About this section

MGI Mouse Phenotypes related to Clubfoot:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.7PITX1, TGFBR2, CHST14, TBX4
2MP:00053718.4PITX1, CHST14, TBX4, SLC26A2, HOXA11
3MP:00053848.0HOXA11, TGFBR2, CHST14, TBX4, SLC26A2
4MP:00053827.9SLC26A2, CHST14, TGFBR2, PITX1, HOXD4
5MP:00053787.5HOXD4, PITX1, TGFBR2, CHST14, SLC26A2
6MP:00053907.0SLC26A2, HOXA11, HOXD4, PITX1, TGFBR2, CHST14
7MP:00107686.9TGFBR2, CHST14, TBX4, SLC26A2, PITX1, HOXA11

Publications for Clubfoot

About this section

Articles related to Clubfoot:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Conservative treatment of severe clubfoot using a novel functional dynamic splint. (25438104)
2015
2
Initial Correction Predicts the Need for Secondary Achilles Tendon Procedures in Patients With Idiopathic Clubfoot Treated With Ponseti Casting. (25730291)
2015
3
The effect of clinical, radiographic and functional scores on the total score in the evaluation of congenital clubfoot. (25568547)
2014
4
Ponseti treatment for clubfoot in Romania: a 9-year single-centre experience. (25153646)
2014
5
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
6
Comment on Morin et al "Positive Communication Paradigm Decreases Early Recurrence in Clubfoot Treatment" (25122079)
2014
7
Is tibialis anterior tendon transfer effective for recurrent clubfoot? (24061847)
2014
8
Worldwide spread of the Ponseti method for clubfoot. (25405086)
2014
9
Classification of relapse pattern in clubfoot treated with Ponseti technique. (25298569)
2014
10
Idiopathic clubfoot: ten year follow-up after a soft tissue release procedure. (25231572)
2014
11
Propofol sedation for infants with idiopathic clubfoot undergoing percutaneous tendoachilles tenotomy. (23232381)
2013
12
Descriptive epidemiology of idiopathic clubfoot. (23686911)
2013
13
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
2012
14
Treatment results of late-relapsing idiopathic clubfoot previously treated with the Ponseti method. (22584843)
2012
15
Post clubfoot release skin necrosis: a preventable disaster. (21526037)
2011
16
The influence of brace type on the success rate of the Ponseti treatment protocol for idiopathic clubfoot. (22468155)
2011
17
Long-term results of the posteromedial release in the treatment of idiopathic clubfoot. (20864856)
2010
18
Clubfoot classification: correlation with Ponseti cast treatment. (20864855)
2010
19
Bracing following correction of idiopathic clubfoot using the Ponseti method. (20675641)
2010
20
Magnetic resonance angiography in clubfoot and vertical talus: a feasibility study. (19127394)
2009
21
CT study on the effect of different treatment protocols for clubfoot pathology. (19190974)
2009
22
Early results of the Ponseti method for the treatment of clubfoot associated with myelomeningocele. (19487512)
2009
23
Clubfoot: etiology and treatment Ignacio V. Ponseti, MD, 1914-. (19184257)
2009
24
Clubfoot treatment: Ponseti and French functional methods are equally effective. (19242767)
2009
25
Evaluation of the utility of the Ponseti method of correction of clubfoot deformity in a developing nation. (17115153)
2008
26
Clubfoot: etiology and treatment. (19823650)
2008
27
Results of manipulation of idiopathic clubfoot deformity in Malawi by orthopaedic clinical officers using the Ponseti method: a realistic alternative for the developing world? (18209628)
2007
28
Results of an accelerated Ponseti protocol for clubfoot. (16199943)
2005
29
Radical soft-tissue release of the arthrogrypotic clubfoot. (15703521)
2005
30
Bleeding complications following percutaneous tendoachilles tenotomy in the treatment of clubfoot deformity. (15205614)
2004
31
Validity of the anteroposterior talocalcaneal angle to assess congenital clubfoot correction. (15100132)
2004
32
The effect of the internet in the treatment of congenital idiopathic clubfoot. (14575256)
2003
33
Anthropometric study of patients treated for clubfoot. (12826950)
2003
34
Joint laxity and the risk of clubfoot. (14632308)
2003
35
The ponseti technique for correction of congenital clubfoot. (12377924)
2002
36
Regional fasciocutaneous flap closure for clubfoot surgery. (11176353)
2001
37
Anterior tibial tendon transfer in residual dynamic clubfoot deformity. (11176351)
2001
38
Ankle and first metatarsophalangeal joint dorsiflexion in children with clubfoot. (11675544)
2001
39
Comparison of the soft-tissue release methods in idiopathic clubfoot. (11008747)
2000
40
Postoperative blood loss into plaster casts after clubfoot surgery: an experimental model. (10218182)
1999
41
Surgical treatment of clubfoot: the significance of talocalcaneonavicular malposition correction. (10709589)
1999
42
Rotation fasciocutaneous flap for neglected clubfoot: a new technique. (9600556)
1998
43
Cases of congenital dislocation of the knee (CDK) not associated with clubfoot, arthrogryposis multiplex congenita, and Larsen's syndrome can be treated conservatively. (9531418)
1998
44
Long-term results of the operative treatment of clubfoot: a representative study. (9642705)
1998
45
Regional anesthesia for clubfoot surgery in children. (10099069)
1998
46
Muscle and tendon size relationships in a paralyzed chick embryo model of clubfoot. (9600555)
1998
47
A personal revolution in the development of clubfoot correction. (9030444)
1997
48
Controversies in the surgical management of clubfoot. (8727753)
1996
49
Treatment of idiopathic clubfoot. A thirty-year follow-up note. (8876592)
1996
50
Esophageal atresia, coloboma, and clubfoot in two unrelated infants. (6469248)
1984

Variations for Clubfoot

About this section

Expression for genes affiliated with Clubfoot

About this section
Search GEO for disease gene expression data for Clubfoot.

Pathways for genes affiliated with Clubfoot

About this section

Pathways related to Clubfoot according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TGFBR2, HOXA11

Compounds for genes affiliated with Clubfoot

About this section
Sources:
43Novoseek, 24HMDB
See all sources

Compounds related to Clubfoot according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1gnrh439.5TGFBR2, PITX1
2sulfate43 2410.3SLC26A2, CHST14

GO Terms for genes affiliated with Clubfoot

About this section

Cellular components related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:00056679.6PITX1, HOXA11

Biological processes related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1embryonic limb morphogenesisGO:00303269.7HOXA11, TBX4
2skeletal system developmentGO:00015019.6HOXA11, PITX1
3cartilage developmentGO:00512169.5PITX1, TGFBR2
4anatomical structure morphogenesisGO:00096539.5HOXA11, PITX1
5glycosaminoglycan metabolic processGO:00302039.3SLC26A2, CHST14
6multicellular organismal developmentGO:00072758.8TBX4, HOXD4, HOXA11

Molecular functions related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:00435658.8PITX1, HOXD4, HOXA11
2sequence-specific DNA binding transcription factor activityGO:00037008.0TBX4, PITX1, HOXD4, HOXA11

Products for genes affiliated with Clubfoot

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Clubfoot

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet