Clubfoot disease: drugs, articles, genes, clinical trials

Summaries for Clubfoot

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⁴⁴Wikipedia, ³³OMIM, ²²MalaCards
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Wikipedia: A club foot, or congenital talipes equinovarus (CTEV), is a congenital deformity involving one foot or...⁴⁴ more...

MalaCards: Clubfoot, also known as equinovarus deformity of foot (finding), is related to vertical talus and ehlers-danlos syndrome. An important gene associated with Clubfoot is CHST14 (carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14), and among its related pathways are Colorectal cancer and Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins. The compounds egcg and valproic acid have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, and related mouse phenotypes are limbs/digits/tail and embryogenesis.

OMIM: 119800

Aliases & Descriptions for Clubfoot

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Sources:
⁶Disease Ontology, ⁸DISEASES, ³²Novoseek , ⁴³UMLS, ³³OMIM, ⁴⁰SNOMED-CT, ¹⁹ICD9CM, ²⁴MeSH, ²⁷NCIt
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Aliases & Descriptions:

clubfoot ⁶ ⁸ ³²

equinovarus deformity of foot (finding) ⁶

congenital talipes equinovarus ⁶

neonatal hemochromatosis ⁴³

congenital equinovarus ⁶

clubfoot, congenital ³³

congenital clubfoot ⁶

club foot ³²

External Ids:

ICD9CM¹⁹ 754.51

MeSH²⁴ C538680, D003025

SNOMED-CT⁴⁰ 397932003, 268341008, 268340009 33163000, 249808002, 156987002, 205089003, 253957000, 156985005, 15169008, more

NCIt²⁷ C84641

OMIM³³ 119800

UMLS⁴³ C0009081

Related Diseases for Clubfoot

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to clubfoot by text searches and GeneDecks gene sharing:

(show top 50) (show all 305)

id	Related Disease	Score	Top Affiliating Genes
1	vertical talus	30.2	HOXD10, TPM2, GDF5, MYH3
2	ehlers-danlos syndrome	27.9	CHST14, PLOD2, COL2A1, PITX1
3	talipes equinovarus	24.8	NAT1, NAT2, BID, BCL2, FHL1, APAF1
4	neuronitis	21.8	NAT1, NAT2, BID, BCL2, KAL1, FHL1
5	arthrogryposis distal type 2b	13.6	TPM2, MYH3
6	vacterl association	13.5	HOXA5, HOXD13, HOXD3
7	brachydactyly-syndactyly syndrome	13.4	HOXD10, HOXD11, HOXD12, HOXD13, HOXD9
8	polydactyly	13.3	HOXA@, HOXD11, HOXD12, HOXD13, GDF5
9	caspase-8 deficiency	13.2	CASP10, CASP8
10	synpolydactyly	13.2	HOXD10, HOXD11, HOXD12, HOXD13, HOXD4, HOXD9
11	arthrogryposis multiplex congenita distal	13.2	TPM2, MYH3
12	hepatocellular carcinoma, somatic	13.1	CASP8, CTNNB1
13	arthrogryposis	12.9	MYBPC1, TPM2, PLOD2, MYH3
14	syndactyly	12.9	HOXD1, HOXD10, HOXD11, HOXD12, HOXD13, HOXD9
15	distal arthrogryposis	12.9	MYBPC1, TPM2, MYH3
16	multiple chemical sensitivity	12.9	NAT1, NAT2, MTHFR
17	brachydactyly	12.8	CHST3, HOXD10, HOXD11, HOXD12, HOXD13, HOXD9
18	dwarfism	12.8	IGFBP3, HOXA5, COL2A1, GDF5
19	sycp3-related pregnancy loss, susceptibility to	12.8	MTHFR, HOXA10, CYP1A1
20	oral cavity cancer	12.7	NAT2, CASP8, CYP1A1
21	rheumatoid arthritis, association with	12.7	NAT2, MTHFR, PLOD2, COL2A1
22	short stature	12.6	CHST3, IGFBP3, HOXD13, PLOD2, COL2A1, GDF5
23	thoracic cancer	12.5	CASP3, CASP8, CASP9
24	birth defects	12.5	MTHFR, CTNNB1, EPHX1
25	acute lymphocytic leukemia	12.4	BCL2, MTHFR, HOXA10, HOXA5, HOXA9
26	orofacial cleft	12.3	NAT1, NAT2, MTHFR, CYP1A1, EPHX1
27	hereditary mucosal leukokeratosis	12.3	NAT2, BCL2, CYP1A1, CTNNB1
28	adenomyosis	12.3	BCL2, HOXA10, CYP1A1, CTNNB1
29	leukoplakia	12.2	NAT2, BCL2, CYP1A1, CTNNB1
30	cleft palate	12.1	NAT1, NAT2, MTHFR, KAL1, HOXA2, COL2A1
31	li-fraumeni syndrome	11.9	NAT2, BCL2, IGFBP3, CYP1A1
32	boomerang dysplasia	11.9	BCL2, CASP8, CTNNB1, COL2A1, EPHX1, GDF5
33	peripheral primitive neuroectodermal tumor	11.9	BCL2, CASP3, CASP8, CASP9
34	thyroid cancer, anaplastic	11.8	CASP3, CASP8, CTNNB1
35	primary effusion lymphoma	11.8	BCL2, CASP3, CASP8, CTNNB1
36	acute promyelocytic leukemia	11.7	BCL2, CASP3, CASP8, CASP9
37	rabies	11.7	NAT2, BCL2, CASP8, CASP9, CTNNB1, EPHX1
38	chronic lymphocytic leukemia	11.7	BCL2, APAF1, CASP10, CASP3, CASP8
39	pharyngitis	11.7	NAT1, NAT2, BCL2, FHL1, HOXA@, CYP1A1
40	chronic myeloid leukemia	11.7	BCL2, APAF1, CASP3, CASP9, HOXA10, HOXA9
41	testicular germ cell tumor	11.7	APAF1, IGFBP3, CASP3, CASP8, CYP1A1
42	pediatric cns embryonal cell carcinoma	11.7	APAF1, CASP3, CASP8, CASP9, HOXA5, HOXD4
43	rhabdomyosarcoma	11.6	BID, BCL2, CASP10, CASP8, CASP9, CTNNB1
44	testicular cancer	11.6	NAT2, IGFBP3, CASP3, CASP8, CASP9, HOXA9
45	endometrial adenocarcinoma	11.5	BCL2, IGFBP3, HOXA10, HOXA11, HOXD10, CYP1A1
46	toxoplasmosis	11.5	BCL2, CASP3, CASP8, CASP9, COL2A1
47	lung occult squamous cell carcinoma	11.5	BCL2, CASP3, CYP1A1, CTNNB1, EPHX1
48	nasopharynx carcinoma	11.5	NAT2, BCL2, CASP3, CASP9, CYP1A1
49	parkinson's disease	11.5	NAT2, APAF1, CASP3, CASP8, CASP9, CYP1A1
50	childhood leukemia	11.5	BCL2, MTHFR, CASP3, CYP1A1

Graphical network of the top 20 diseases related to clubfoot:

Graphical network of diseases related to clubfoot

Clinical Features for Clubfoot

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³³OMIM
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Clinical features from OMIM: 119800

Drugs & Therapeutics for Clubfoot

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⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Clubfoot

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Anatomical Context for Clubfoot

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²²MalaCards
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MalaCards organs/tissues related to clubfoot:

²²

Skeletal muscle

Phenotypes for genes affiliated with Clubfoot

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²⁵MGI
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MGI Mouse Phenotypes related to clubfoot:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail phenotype	MP:0005371	INF	HOXD9, HOXD@, CTNNB1, , , WNT7A
2	embryogenesis phenotype	MP:0005380	INF	HOXD3, HOXD@, CTNNB1, , , WNT7A
3	mortality/aging	MP:0010768	INF	HOXD3, HOXD4, HOXD9, HOXD@, ,
4	digestive/alimentary phenotype	MP:0005381	INF	HOXD13, HOXD@, CTNNB1, , , HOXD12
5	growth/size phenotype	MP:0005378	INF	HOXA9, HOXD13, HOXD4, CYP1A1, CTNNB1,
6	cardiovascular system phenotype	MP:0005385	INF	WNT7A, , , CTNNB1, CYP1A1, HOXD3
7	hearing/vestibular/ear phenotype	MP:0005377	INF	, , CTNNB1, HOXA5, HOXA2, CASP3
8	reproductive system phenotype	MP:0005389	7.9	HOXD11, HOXD12, HOXD4, WNT7A, GDF5, HOXD10
9	endocrine/exocrine gland phenotype	MP:0005379	INF	HOXA9, HOXD13, HOXD3, HOXD9, CTNNB1,
10	renal/urinary system phenotype	MP:0005367	INF	, CTNNB1, HOXD9, HOXD13, HOXD11, HOXD10
11	respiratory system phenotype	MP:0005388	INF	, HOXD3, HOXA2, BID
12	nervous system phenotype	MP:0003631	INF	HOXD10, HOXD11, HOXD12, HOXD13, HOXD3, HOXD9
13	muscle phenotype	MP:0005369	INF	, CTNNB1, HOXD9, HOXD13, HOXD12, HOXD10
14	skeleton phenotype	MP:0005390	INF	MTHFR, HOXD13, HOXD3, HOXD8, HOXD9, HOXD@
15	craniofacial phenotype	MP:0005382	INF	, HOXD4, HOXD3, HOXD1, HOXA5, HOXA2
16	vision/eye phenotype	MP:0005391	INF	CTNNB1, HOXD13, HOXA5, CASP3, APAF1, MTHFR

Publications for genes affiliated with Clubfoot

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³⁵PubMed
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Articles related to clubfoot:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	Loss of dermatan-4-sulfotransferase 1 (D4ST1/CHST14) function represents the first dermatan sulfate biosynthesis defect, 'derma tan sulfate-deficient adducted thumb-clubfoot syndrome'. (21309034)	Janecke A.R.... DA1ndar M.	2011	CHST14
2	Smoking, the xenobiotic pathway, and clubfoot. (21254355)	Sommer A.... Hecht J.T.	2011	CYP1A1, NAT2, EPHX1
3	Evaluation of embryonic and perinatal myosin gene mut ations and the etiology of congenital idiopathic clubfoot. (20357587)	Shyy W.... Morcuende J.A.	2010	MYH3
4	Musculocontractural Ehlers-Danlos syndrome (former EDS type VIB) and adducted thumb clubfoot syndrome (ATCS) represent a single clinical entity caused by mutations in the dermatan-4-sulfotransferase 1 encoding CHST14 gene. (20842734)	Malfait F.... De Paepe A.	2010	CHST14
5	Loss of dermatan-4-sulfotransferase 1 function result s in adducted thumb-clubfoot syndrome. (20004762)	DA1ndar M.... Janecke A.R.	2009	CHST14
6	Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot. (19142688)	Gurnett C.A.... Dobbs M.B.	2009	MYH3
7	Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot. (19159115)	Shyy W.... Morcuende J.A.	2009	WNT7A, CAND2
8	Altered transmission of HOX and apoptotic SNPs identi fy a potential common pathway for clubfoot. (19938081)	Ester A.R.... Hecht J.T.	2009	IGFBP3, HOXD4, HOXA10
9	Magnetic resonance angiography in clubfoot and vertical talus: a feasibility study. (19127394)	Kruse L.... Dobbs M.B.	2009	GDF5
10	Beta-catenin mediates soft tissue contracture in clubfoot. (19169765)	Poon R.... Alman B.A.	2009	CTNNB1
11	HOXD13 may play a role in idiopathic congenital clubfoot by regulating the expression of FHL1. (18758158)	Wang L.L.... Sun K.L.	2008	FHL1, HOXD13
12	Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)	Ester A.R.... Hecht J.T.	2007	BCL2, CASP3, CASP10
13	NAT2 variation and idiopathic talipes equinovarus (clubfoot). (17726690)	Hecht J.T.... Blanton S.H.	2007	NAT1, NAT2
14	Absence of HOXD10 mutations in idiopathic clubfoot and sporadic vertical talus. (17417092)	Gurnett C.A.... Dobbs M.B.	2007	HOXD10
15	The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR), maternal use of folic acid supplements, and risk of isolated clubfoot: A case-parent-triad analysis. (16936070)	Sharp L.... Maffulli N.	2006	MTHFR

Genes related to Clubfoot

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¹³GeneCards
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Genes related to clubfoot according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	CHST14	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	11.1	Summaries, Publications
2	HOXD@	homeobox D cluster	11.0	Publications
3	HOXA@	homeobox A cluster	11.0	Publications
4	HOXD1	homeobox D1	11.0	Publications
5	HOXD11	homeobox D11	11.0	Publications
6	HOXD12	homeobox D12	11.0	Publications
7	HOXD8	homeobox D8	11.0	Publications
8	HOXD3	homeobox D3	11.0	Publications
9	HOXA5	homeobox A5	11.0	Publications
10	HOXD10	homeobox D10	11.0	Publications
11	HOXA2	homeobox A2	11.0	Publications
12	HOXD4	homeobox D4	11.0	Publications
13	HOXD9	homeobox D9	11.0	Publications
14	HOXA11	homeobox A11	11.0	Publications
15	HOXD13	homeobox D13	11.0	Publications
16	HOXA9	homeobox A9	11.0	Publications
17	CAND2	cullin-associated and neddylation-dissociated 2 (putative)	11.0	Publications
18	HOXA10	homeobox A10	11.0	Publications
19	MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	11.0	Publications
20	GDF5	growth differentiation factor 5	11.0	Publications
21	FHL1	four and a half LIM domains 1	11.0	Publications
22	WNT7A	wingless-type MMTV integration site family, member 7A	11.0	Publications
23	CASP10	caspase 10, apoptosis-related cysteine peptidase	11.0	Publications
24	APAF1	apoptotic peptidase activating factor 1	11.0	Publications
25	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	11.0	Publications
26	EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	11.0	Publications
27	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
28	BID	BH3 interacting domain death agonist	11.0	Publications
29	CASP9	caspase 9, apoptosis-related cysteine peptidase	11.0	Publications
30	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
31	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
32	CASP8	caspase 8, apoptosis-related cysteine peptidase	11.0	Publications
33	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
34	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
35	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
36	BCL2	B-cell CLL/lymphoma 2	11.0	Publications

Expression for genes affiliated with Clubfoot

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Clubfoot

Pathways for genes affiliated with Clubfoot

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²⁰KEGG, ⁴¹Thomson Reuters, ¹⁰EMD Millipore, ³⁶QIAGEN, ³⁴PharmGKB, ³⁷R&D Systems, ³Cell Signaling Technology
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Pathways related to clubfoot according to GeneDecks:

(show top 50) (show all 55)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer²⁰	10.0	CASP9
2	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins⁴¹	9.0	CASP9, CASP8, APAF1, BCL2, BID
3	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins¹⁰	9.0	CASP9, CASP8, APAF1, BCL2, BID
4	GITR Pathway³⁶	8.9	CASP10, CASP3, CASP8, CASP9
5	UVA-Induced MAPK Signaling³⁶	8.9	CASP3, CASP8
6	Nur77 Signaling in T-Cell³⁶	8.8	CASP9, CASP3, APAF1, BCL2
7	TNF-Induced Apoptosis Implicating Sphingolipids³⁶	8.8	CASP10, CASP3, CASP8, CASP9
8	Apoptosis and survival_Role of CDK5 in neuronal death and survival⁴¹	8.8	CASP9, CASP3, APAF1, BCL2
9	Apoptosis and survival Role of CDK5 in neuronal death and survival¹⁰	8.7	CASP9, CASP3, APAF1, BCL2
10	Granzyme-B Pathway³⁶	8.7	CASP9, CASP8, CASP3, APAF1, BID
11	DR3 Signaling³⁶	8.7	CASP9, CASP8, CASP3, APAF1, BID
12	Granzyme Pathway³⁶	8.7	CASP9, CASP8, CASP3, APAF1, BID
13	TWEAK Pathway³⁶	8.7	CASP9, CASP8, CASP3, APAF1, BID
14	TRAIL Pathway³⁶	8.7	CASP9, CASP8, CASP3, APAF1, BID
15	CTL Mediated Apoptosis³⁶	8.7	CASP9, CASP8, CASP3, APAF1, BID
16	all-trans-Retinoic Acid Mediated Apoptosis³⁶	8.6	CASP9, CASP8, CASP3, APAF1, BID
17	TNFR1 Pathway³⁶	8.6	CASP9, CASP8, CASP3, APAF1, BID
18	Viral myocarditis²⁰	8.6	MYH3, CASP9, CASP8, CASP3, BID
19	TNF Signaling³⁶	8.6	CASP9, CASP8, CASP3, APAF1, BID
20	Apoptotic Pathways Triggered By HIV1³⁶	8.6	CASP9, CASP3, APAF1, BCL2, BID
21	Amyotrophic lateral sclerosis (ALS)²⁰	8.5	CASP9, CASP3, APAF1, BCL2, BID
22	Apoptosis and survival_Caspase cascade⁴¹	8.5	CASP9, CASP8, CASP3, CASP10, APAF1, BID
23	Apoptosis and survival Caspase cascade¹⁰	8.5	CASP9, CASP8, CASP3, CASP10, APAF1, BID
24	Fas Signaling³⁶	8.5	CASP9, CASP8, CASP3, CASP10, APAF1, BID
25	Caspase Cascade³⁶	8.4	CASP9, CASP8, CASP3, CASP10, APAF1, BID
26	Celecoxib Pathway, Pharmacodynamics³⁴	8.4	CTNNB1, CASP9, CASP3, IGFBP3
27	Ceramide Pathway³⁶	8.4	CASP9, CASP8, CASP3, CASP10, BCL2
28	Alzheimers disease²⁰	8.3	CASP8, CASP3, APAF1, BID, CASP9
29	p53 signaling pathway²⁰	8.3	CASP9, CASP8, CASP3, IGFBP3, APAF1, BID
30	p53 Signaling³⁶	8.2	CASP9, CASP8, CASP3, CASP10, BCL2
31	Apoptosis and survival_Apoptotic TNF-family pathways⁴¹	8.2	BCL2, CASP10, CASP3, CASP8, CASP9, BID
32	Apoptosis and survival Apoptotic TNF-family pathways¹⁰	8.2	CASP9, CASP8, CASP3, CASP10, BCL2, BID
33	14-3-3 Induced Apoptosis³⁶	8.1	CASP9, CASP8, CASP3, CASP10, BCL2, BID
34	Apoptosis and survival FAS signaling cascades¹⁰	8.0	BID, CASP9, CASP8, CASP3, CASP10, APAF1
35	Apoptosis and survival_FAS signaling cascades⁴¹	8.0	CASP9, CASP8, CASP3, CASP10, APAF1, BCL2
36	Apoptosis and survival_TNFR1 signaling pathway⁴¹	8.0	BCL2, APAF1, CASP10, CASP3, CASP8, CASP9
37	Apoptosis and survival TNFR1 signaling pathway¹⁰	8.0	CASP9, BID, BCL2, APAF1, CASP10, CASP3
38	Apoptosis through Death Receptors³⁶	8.0	CASP9, CASP8, CASP3, CASP10, APAF1, BCL2
39	Apoptosis Signaling Pathways³⁷	8.0	CASP9, CASP8, CASP3, CASP10, APAF1, BCL2
40	Apoptosis²⁰	7.9	CASP9, CASP8, CASP3, CASP10, APAF1, BCL2
41	p53 Mediated Apoptosis³⁶	7.9	GDF5, CASP9, CASP8, CASP3, APAF1, BCL2
42	Mitochondrial Apoptosis³⁶	7.9	GDF5, CASP9, CASP8, CASP3, APAF1, BCL2
43	Apoptosis and Autophagy³	7.9	CASP9, CASP8, CASP3, CASP10, APAF1, BCL2
44	Cellular Apoptosis Pathway³⁶	7.9	GDF5, CASP9, CASP8, CASP3, APAF1, BCL2
45	PAK Pathway³⁶	7.9	MYH3, GDF5, CASP9, CASP8, CASP3, CASP10
46	Tuberculosis²⁰	7.8	CASP9, CASP8, CASP3, CASP10, APAF1, BCL2
47	Presenilin-Mediated Signaling³⁶	7.7	WNT7A, CTNNB1, CASP9, CASP8, CASP3, CASP10
48	DHA Signaling³⁶	7.7	GDF5, CASP9, CASP8, CASP3, CASP10, APAF1
49	Pathways in cancer²⁰	7.6	WNT7A, CTNNB1, CASP9, CASP8, CASP3, BCL2
50	Molecular Mechanisms of Cancer³⁶	INF	GDF5, , CTNNB1, CASP8, CASP3, APAF1

Compounds for genes affiliated with Clubfoot

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³²Novoseek , ³⁴PharmGKB, ⁹DrugBank, ¹⁸HMDB, ⁴²Tocris Bioscience
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Compounds related to clubfoot according to GeneDecks:

(show top 50) (show all 118)

id	Compound	Score	Top Affiliating Genes
1	egcg³²	10.1	CASP9, IGFBP3
2	valproic acid³² ³⁴ ⁹ ¹⁸ ⁹	13.7	EPHX1, CYP1A1, APAF1
3	3-nitrobenzanthrone³²	9.5	NAT1, CYP1A1, NAT2
4	phip³²	9.1	NAT1, CYP1A1, NAT2, CTNNB1
5	gsts³²	9.0	NAT2, EPHX1, CYP1A1, NAT1, MTHFR
6	d-api³²	9.0	CASP3, CASP8, CASP9
7	2-chlorodeoxyadenosine³²	8.8	CASP9, CASP8, APAF1, BCL2
8	oridonin³²	8.8	CASP3, BCL2, CASP9
9	bongkrekic acid³²	8.7	CASP9, CASP8, CASP3, BCL2
10	parthenolide³²	8.7	BID, CASP8, CASP3, CASP9
11	shikonin³²	8.7	CASP9, CASP8, CASP3, BCL2
12	betulinic acid³²	8.7	CASP8, CASP9, CASP3, BCL2
13	beta-lapachone³²	8.7	BCL2, CTNNB1, CASP9, CASP3
14	vitamin e succinate³²	8.7	BCL2, CASP3, CASP9, CASP8
15	sulindac sulfide³²	8.6	CASP9, CASP8, BCL2, CASP3
16	betacarotene³²	8.6	NAT2, CYP1A1, CASP8, IGFBP3, MTHFR
17	z-vad-fmk³² ⁴²	9.5	CASP8, CASP3, BCL2, CASP9, CASP10
18	4,6-diamidino-2-phenylindole³²	8.4	BID, CASP9, CASP8, CASP3, BCL2
19	cd 437³²	8.4	BID, CASP9, CASP8, CASP3, BCL2
20	sulindac³² ⁹ ⁹	10.4	CTNNB1, CYP1A1, CASP8, BCL2, CASP9
21	suberoylanilide hydroxamic acid³²	8.4	BCL2, BID, CASP3, CASP9, CASP8
22	triptolide³²	8.3	CASP3, BCL2, CASP9, CASP8
23	flavopiridol³² ⁹ ⁹	10.3	CASP3, CASP8, BCL2, BID, CASP9
24	n-(4-hydroxyphenyl)retinamide³²	8.3	BCL2, IGFBP3, CASP9, CASP3, CASP8
25	noxa³²	8.2	BID, BCL2, APAF1, CASP9, CASP3, CASP8
26	sulforaphane³²	8.1	CASP8, CYP1A1, CASP9, BCL2, CASP3
27	camptothecin³² ⁴² ⁹ ⁹	11.1	CASP3, CASP9, APAF1, BCL2, CASP8, BID
28	gemcitabine³² ³⁴ ⁹ ⁹	11.0	BID, CASP9, CASP8, CASP3, MTHFR, BCL2
29	etoposide³² ⁴² ⁹ ⁹	11.0	BID, APAF1, CASP3, CASP8, BCL2, CASP9
30	daunorubicin³² ⁹ ⁹	10.0	CASP8, BCL2, CASP3, CASP9, CYP1A1
31	sanguinarine³²	7.8	BID, CYP1A1, BCL2, CASP9, CASP8, CASP3
32	phenethyl isothiocyanate³²	7.8	CASP9, BID, BCL2, CASP3, CASP8, CYP1A1
33	mg 132³² ⁴²	8.8	CASP8, CTNNB1, CASP3, CASP9, BCL2, BID
34	docetaxel³² ³⁴ ⁹ ⁹	10.7	BID, BCL2, CASP3, CASP8, CASP9
35	doxorubicin³² ³⁴ ⁹ ⁹	10.7	CTNNB1, CASP8, BID, APAF1, IGFBP3, CASP3
36	adpribose³²	7.7	CTNNB1, CASP9, CASP8, CASP3, BCL2, BID
37	indole-3-carbinol³²	7.6	CTNNB1, CYP1A1, BCL2, CASP9, CASP8, CASP3
38	celecoxib³² ⁴² ³⁴ ⁹ ¹⁸ ⁹	12.6	CTNNB1, BCL2, APAF1, CASP3, CASP8, IGFBP3
39	bortezomib³² ⁹ ⁹	9.6	BID, BCL2, APAF1, CASP8, CYP1A1, CASP9
40	quercetin³² ⁴² ⁹ ¹⁸ ⁹	11.4	CASP8, CYP1A1, CASP9, BCL2, CASP3, CTNNB1
41	5fluorouracil³²	7.4	MTHFR, IGFBP3, CASP3, CASP8, BID, CTNNB1
42	arsenite³² ¹⁸	8.3	CTNNB1, CYP1A1, CASP9, CASP8, CASP3, BCL2
43	butyrate³²	7.2	CASP3, CTNNB1, BCL2, BID, CASP9, CASP8
44	resveratrol³² ⁹ ¹⁸ ⁹	9.8	EPHX1, BCL2, CASP3, CASP8, CASP9, CYP1A1
45	curcumin³²	6.6	NAT1, BCL2, BID, CASP9, CYP1A1, CTNNB1
46	cisplatin³² ³⁴ ⁹ ⁹	9.2	CTNNB1, BID, BCL2, APAF1, MTHFR, IGFBP3
47	paclitaxel³² ³⁴ ⁹ ⁹	9.1	CTNNB1, CASP8, BID, BCL2, IGFBP3, CASP10
48	retinoic acid³² ⁴² ¹⁸	INF	HOXA5, CASP9, CASP8, CASP3, IGFBP3, MTHFR
49	cycloheximide³²	INF	BID, , CTNNB1, CYP1A1, CASP9, CASP8
50	cysteine³²	INF	CASP9, CTNNB1, , GDF5, CASP8, CASP3

GO Terms for genes affiliated with Clubfoot

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Sources:
¹²Gene Ontology
See all sources

Cellular components related to clubfoot according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	NAT1, MYH3, CTNNB1, , CASP9, CASP8
2	apoptosome	GO:043293	9.6	APAF1, CASP9
3	nucleus	GO:005634	5.1	HOXD1, HOXD10, HOXD11, HOXD13, HOXD3, HOXD4

Biological processes related to clubfoot according to GeneDecks:

(show all 26)

id	Name	GO ID	Score	Top Affiliating Genes
1	skeletal system development	GO:001501	INF	, , HOXD13, HOXD12, HOXA11, HOXA10
2	muscle filament sliding	GO:030049	INF	, , MYH3
3	positive regulation of cell development	GO:010720	10.4	HOXD11, HOXA11
4	hindlimb morphogenesis	GO:035137	10.3	HOXD10, HOXD9, GDF5
5	positive regulation of chondrocyte differentiation	GO:032332	10.3	GDF5, HOXD11, HOXA11
6	embryonic skeletal system morphogenesis	GO:048704	10.1	HOXD9, HOXD4, HOXD3, HOXD10, HOXA5
7	embryonic limb morphogenesis	GO:030326	10.1	GDF5, HOXD10, HOXA11, HOXA10
8	proximal/distal pattern formation	GO:009954	10.0	HOXD9, HOXD11, HOXD10, HOXA11, HOXA10
9	dorsal/ventral pattern formation	GO:009953	9.9	HOXD11, HOXA2, HOXA11
10	oviduct development	GO:060066	9.9	WNT7A, CTNNB1
11	glial cell apoptotic process	GO:034349	9.9	BCL2, BID
12	developmental growth	GO:048589	9.9	BCL2, HOXA11, HOXD11
13	metanephros development	GO:001656	9.8	HOXD11, HOXA11, BCL2
14	embryonic digit morphogenesis	GO:042733	9.5	WNT7A, CTNNB1, HOXD13, HOXD12, HOXD11, HOXA11
15	branching involved in ureteric bud morphogenesis	GO:001658	9.4	BCL2, HOXA11, HOXD11
16	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	GO:008635	9.4	CASP9, CASP3, APAF1
17	anterior/posterior pattern specification	GO:009952	9.3	HOXA10, HOXD9, HOXD4, HOXD3, HOXD13, HOXD11
18	activation of pro-apoptotic gene products	GO:008633	9.2	BID, BCL2, CASP8
19	release of cytochrome c from mitochondria	GO:001836	9.0	BID, BCL2, CASP3
20	neuron apoptotic process	GO:051402	9.0	BID, BCL2, CASP3
21	induction of apoptosis by intracellular signals	GO:008629	8.1	CASP9, CASP8, CASP3, APAF1, BCL2, BID
22	apoptotic process	GO:006915	7.1	CTNNB1, CASP9, CASP8, CASP3, CASP10, APAF1
23	cartilage development	GO:051216	INF	HOXD3, , WNT7A, GDF5
24	transcription, DNA-dependent	GO:006351	INF	HOXD12, HOXD3, HOXD4, HOXD8, HOXD9, CTNNB1
25	T cell homeostasis	GO:043029	INF	BCL2, , CASP3
26	cartilage development involved in endochondral bone morphogenesis	GO:060351	INF	HOXA11, HOXD11,

Molecular functions related to clubfoot according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	arylamine N-acetyltransferase activity	GO:004060	9.9	NAT1, NAT2
2	cysteine-type endopeptidase activity	GO:004197	8.3	CASP10, CASP3, CASP8, CASP9
3	sequence-specific DNA binding	GO:043565	INF	BCL2, , HOXD9, HOXD8, HOXD4, HOXD3
4	sequence-specific DNA binding transcription factor activity	GO:003700	INF	HOXD13, HOXD3, HOXD4, HOXD8, HOXD9, CTNNB1