MCID: CLB002
MIFTS: 42

Clubfoot malady

Categories: Genetic diseases (common), Bone diseases

Aliases & Classifications for Clubfoot

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Aliases & Descriptions for Clubfoot:

Name: Clubfoot 11 50 39 13
Congenital Talipes Equinovarus 11
Equinovarus Deformity of Foot 11
 
Congenital Equinovarus 11
Congenital Clubfoot 11
Club Foot 50

Classifications:



Summaries for Clubfoot

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Disease Ontology:11 A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.

MalaCards based summary: Clubfoot, also known as congenital talipes equinovarus, is related to arthrogryposis, distal, type 2b and clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly. An important gene associated with Clubfoot is CHST14 (Carbohydrate Sulfotransferase 14), and among its related pathways are Cardiac conduction and Striated Muscle Contraction. Affiliated tissues include bone, skin and skeletal muscle, and related mouse phenotypes are limbs/digits/tail and skeleton.

Wikipedia:71 Club foot or clubfoot, also called Congenital Talipes Equinovarus (CTEV), is a congenital deformity... more...

Related Diseases for Clubfoot

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Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot

Diseases related to Clubfoot via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1arthrogryposis, distal, type 2b30.6MYBPC1, MYH3, TNNT3, TPM2
2clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly12.2
3short stature robin sequence cleft mandible hand anomalies clubfoot11.7
4pitx1-related congenital clubfoot11.7
5familial clubfoot with or without associated lower limb anomalies11.7
6talipes equinovarus11.5
7arthrogryposis, distal, type 311.4
8tarp syndrome11.4
9epiphyseal dysplasia, multiple, 411.3
10moebius syndrome11.0
11robin sequence with cleft mandible and limb anomalies11.0
12ehlers-danlos syndrome, musculocontractural type11.0
13arthrogryposis multiplex congenita, distal, type 110.9
14spondyloepiphyseal dysplasia with congenital joint dislocations10.9
15chromosome 17q23.1-q23.2 duplication syndrome10.9
16arthrogryposis, distal, type 5d10.8
17diastrophic dysplasia10.8
18atelosteogenesis ii10.8
19genitopatellar syndrome10.8
20smed strudwick type10.8
21loeys-dietz syndrome 510.8
22pseudohypoaldosteronism, type iie10.7
23ehlers-danlos syndrome, musculocontractural type 110.7
24lambert syndrome10.7
25vertical talus, congenital10.7
26spondylocarpotarsal synostosis syndrome10.7
27larsen syndrome10.7
28bruck syndrome 210.7
29orofaciodigital syndrome iv10.7
30spondyloperipheral dysplasia10.7
31arthrogryposis, distal, type 1b10.7
32epileptic encephalopathy, early infantile, 2910.7
33short qt syndrome 310.3PITX1, TBX4
34congenital disorder of glycosylation, type iid10.3MYH3, TPM2
35ramos arroyo clark syndrome10.2CHST14, TNNT3
36syndactyly, type v10.0HOXD10, HOXD13
37nemaline myopathy 4, autosomal dominant10.0MYH3, TNNT3, TPM2
38brachydactyly-syndactyly syndrome10.0HOXD10, HOXD13
39myelomeningocele10.0
40myopathy with extrapyramidal signs9.9CHST3, SLC26A2
41specific language impairment9.9HOXD10, HOXD13
42ischemic bone disease9.8HOXD13, SLC26A2
43ehlers-danlos syndrome9.8
44fibrochondrogenesis9.7CHST3, SLC26A2
45familial atrial fibrillation9.7MYBPC1, MYH3, TNNT3, TPM2
46tibial hemimelia9.7
47potocki-lupski syndrome9.7
48marden-walker syndrome9.7
49central core disease9.7
50diastematomyelia9.7

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Symptoms & Phenotypes for Clubfoot

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MGI Mouse Phenotypes related to Clubfoot according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7CHST14, HOXD10, HOXD13, PITX1, SLC26A2, TBX4
2MP:00053907.6CHST14, CHST3, HOXD10, HOXD13, PITX1, SLC26A2

Drugs & Therapeutics for Clubfoot

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Drugs for Clubfoot (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineapprovedPhase 4, Phase 3, Phase 277651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2onabotulinumtoxinAPhase 4, Phase 3, Phase 2626
3abobotulinumtoxinAPhase 4, Phase 3, Phase 2626
4Neurotransmitter AgentsPhase 4, Phase 3, Phase 217734
5incobotulinumtoxinAPhase 4, Phase 3, Phase 2635
6Botulinum Toxins, Type APhase 4, Phase 3, Phase 2630
7Cholinergic AgentsPhase 4, Phase 3, Phase 23846
8Neuromuscular AgentsPhase 3, Phase 21129
9Peripheral Nervous System AgentsPhase 3, Phase 222776
10Botulinum ToxinsPhase 3, Phase 2669
11AnestheticsPhase 39001
12Pharmaceutical SolutionsPhase 27793
13HemagglutininsPhase 2118
14
Mentholapproved23532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
15Neuroserpin3
16Analgesics11287
17AstragalusNutraceutical52

Interventional clinical trials:

(show all 37)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic PatientsCompletedNCT00825097Phase 3
3Study of GSK1358820 In Patients With Post-Stroke Lower Limb SpasticityCompletedNCT00460655Phase 3
4Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral PalsyCompletedNCT02188277Phase 2
5Sucrose Analgesia in Infants Undergoing Casting for Club FootUnknown statusNCT01050088
6Effectiveness of Parents' Manipulation in Newborn With Talipes CalcaneusUnknown statusNCT01767662
7Genetic Disease Gene IdentificationUnknown statusNCT00916903
8Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA)Unknown statusNCT01600183
9Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRICompletedNCT01088828
10Gait Analysis in Ponseti ClubfootCompletedNCT02022267
11Outcomes of Compliance With Brace Wear in ClubfootCompletedNCT01481324
12Polyaxial Brace Fixing for the Treatment of Congenital ClubfootCompletedNCT02815306
13Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)CompletedNCT00474344
14A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot InfantsCompletedNCT02395185
15Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti MethodCompletedNCT01067651
16Treatment of Spastic Equinovarus Foot After StrokeCompletedNCT00199589
17Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootCompletedNCT01265238
18Impairments of Oral Language in Mobius SyndromeCompletedNCT00856531
19Clubfoot DNA RepositoryRecruitingNCT00607191
20Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and ClubfeetRecruitingNCT02755766
21Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic ClubfootRecruitingNCT02815215Early Phase 1
22Using Botox to Treat Patients With Idiopathic ClubfootRecruitingNCT00474032
23Pedobarographic Assessments of Clubfoot Treated PatientsRecruitingNCT00175708
24Prospective Evaluation of Treatment for ClubfootRecruitingNCT02257229
25Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral PalsyRecruitingNCT02814786
26Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar PressureRecruitingNCT02233140
27Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
28Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus FootRecruitingNCT02790346
29Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized TrialActive, not recruitingNCT01551264
30Efficacy of Botox in Patients With Idiopathic ClubfootActive, not recruitingNCT00152334
31A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic ClubfootActive, not recruitingNCT00152347
32Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
33Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles TendonSuspendedNCT01382628
34Ankle Equinus Contracture Treated With Dynamic SplintingTerminatedNCT01238484
35The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon FracturesTerminatedNCT02051933
36Economic Evaluation of Clubfoot Treatment: One Centre's ExperienceWithdrawnNCT00475631
37Instep Plantar Fasciotomy With and Without Gastrocnemius RecessionWithdrawnNCT02287714

Search NIH Clinical Center for Clubfoot


Cochrane evidence based reviews: clubfoot

Genetic Tests for Clubfoot

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Anatomical Context for Clubfoot

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MalaCards organs/tissues related to Clubfoot:

36
Bone, Skin, Skeletal muscle

Publications for Clubfoot

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Articles related to Clubfoot:

(show top 50)    (show all 613)
idTitleAuthorsYear
1
The quality of Achilles tendon repair five to eight years after percutaneous tenotomy in the treatment of clubfoot: clinical and ultrasonographic findings. (28053270)
2017
2
Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus. (26729820)
2016
3
Functional and clinical results achieved in congenital clubfoot patients treated by Ponseti's technique. (28050536)
2016
4
Results of clubfoot treatment after manipulation and casting using the Ponseti method: experience in Harare, Zimbabwe. (27388947)
2016
5
Ponseti method compared to previous treatment of clubfoot in Norway. A multicenter study of 205 children followed for 8-11A years. (27436118)
2016
6
Medial to posterior release procedure after failure of functional treatment in clubfoot: a prospective study. (27032405)
2016
7
Osteogenesis imperfecta and clubfoot-a rare combination: Case report and review of the literature. (27495102)
2016
8
The effectiveness of the Ponseti method for treating clubfoot associated with arthrogryposis: up to 8 years follow-up. (26833334)
2016
9
Bracing in Ponseti Clubfoot Treatment: Improving Parental Adherence Through an Innovative Health Education Intervention. (27028684)
2016
10
Oral Sucrose for Pain Relief During Clubfoot Casting: A Double-Blinded Randomized Controlled Trial. (27636913)
2016
11
Design and descriptive data of the randomized Clubfoot Foot Abduction Brace Length of Treatment Study (FAB24). (27632641)
2016
12
Bracing in Ponseti Clubfoot Treatment: Improving Parental Adherence Through an Innovative Health Education Intervention. (27028685)
2016
13
Surgical treatment of neglected clubfoot using external fixator. (27818969)
2016
14
Mid-term results of Ponseti management for an idiopathic congenital clubfoot at a single center in Vietnam. (26709996)
2016
15
A mini-open technique for Achilles tenotomy in infants with clubfoot. (26825454)
2016
16
Descriptive epidemiology of clubfoot in Romania: a clinic-based study. (26875888)
2016
17
The Dynamicity of Steenbeek Foot Abduction Brace for Clubfoot in Dorsiflexion and Pronation: A Pilot Study. (27036490)
2016
18
Development of congenital clubfoot during growth: a long-term study on the basis of pedobarography, biomechanics, and magnetic resonance imaging measurements of muscle volumes. (26919619)
2016
19
Functional Assessment of Clubfoot Associated HOXA9, TPM1, and TPM2 Variants Suggests a Potential Gene Regulation Mechanism. (27020427)
2016
20
Ponseti treatment for idiopathic clubfoot deformity - Role of secondary care hospitals. (26712195)
2016
21
The Ponseti Method for Clubfoot Treatment in Low and Middle-Income Countries: A Systematic Review of Barriers and Solutions to Service Delivery. (26919713)
2016
22
Factors associated with recurrence of clubfoot treated by the Ponseti method. (27803913)
2016
23
An 18.3-Mb Duplication on Chromosome 14q With Multiple Cardiac Anomalies and Clubfoot Was Identified by Microarray Analysis. (26709274)
2016
24
Gait in 5-year-old children with idiopathic clubfoot: A cohort study of 59 children, focusing on foot involvement and the contralateral foot. (27331243)
2016
25
How Many Patients Who Have a Clubfoot Treated Using the Ponseti Method are Likely to Undergo a Tendon Transfer? (27379785)
2016
26
Ponseti Treatment of Rigid Residual Deformity in Congenital Clubfoot After Walking Age. (27869621)
2016
27
Initial treatment of congenital idiopathic clubfoot: Prognostic factors. (27765520)
2016
28
Modified Lambrinudi Arthrodesis for the Acute Treatment of Neurogenic Clubfoot: A Case Report. (27920102)
2016
29
The Objective Measurement of Brace-Use Adherence in the Treatment of Idiopathic Clubfoot. (27707845)
2016
30
The impact of the Ponseti treatment method on parents and caregivers of children with clubfoot: a comparison of two urban populations in Europe and Africa. (26898213)
2016
31
Clubfoot treatment: Implementation of the Ponseti method in emerging countries. (27046927)
2016
32
Association between maternal age at conception and risk of idiopathic clubfoot. (26901038)
2016
33
Treatment of congenital clubfoot using Ponseti method. (27274485)
2016
34
Nail changes in casted and braced clubfoot: A preliminary study. (27810019)
2016
35
Walk for life - the National Clubfoot Project of Bangladesh: the four-year outcomes of 150 congenital clubfoot cases following Ponseti method. (27833661)
2016
36
Prognosticating Factors of Relapse in Clubfoot Management by Ponseti Method. (27662384)
2016
37
Evaluation of Ponseti method in neglected clubfoot. (27746497)
2016
38
Problems encountered by parents of infants with clubfoot treated by the Ponseti method in Madagascar: A study to inform better practice. (27058615)
2016
39
Effectiveness of the Ponseti method for treating clubfoot associated with myelomeningocele: 3-9 years follow-up. (27386794)
2016
40
The clubfoot over the centuries through the documentation present in the literature and art. (27392302)
2016
41
Effect of a modified dynamic accordion hinge Denis Browne brace on the success rate of the Ponseti method in idiopathic clubfoot: a preliminary study. (27341119)
2016
42
The Ponseti technique and improved ankle dorsiflexion in children with relapsed clubfoot: a retrospective data analysis. (27649368)
2016
43
What is new in idiopathic clubfoot? (27696325)
2016
44
Are incidence and severity of clubfoot related to the season of birth? (27351571)
2016
45
Treatment of complex idiopathic clubfoot using the modified Ponseti method: up to 11 years follow-up. (27104942)
2016
46
Evolution of clubfoot deformity and muscle abnormality in the Ponseti method: evaluation with the Dimeglio score. (27349648)
2016
47
What factors affect patient access and engagement with clubfoot treatment in low- and middle-income countries? Meta-synthesis of existing qualitative studies using a social ecological model. (26892686)
2016
48
Comparison of the Ponseti method versus early tibialis anterior tendon transfer for idiopathic clubfoot: A prospective randomized study. (27496186)
2016
49
Evaluation of gait, relapse and compliance in clubfoot treatment with custom-made orthoses. (27544063)
2016
50
Initial Correction Predicts the Need for Secondary Achilles Tendon Procedures in Patients With Idiopathic Clubfoot Treated With Ponseti Casting. (25730291)
2015

Variations for Clubfoot

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Expression for genes affiliated with Clubfoot

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Search GEO for disease gene expression data for Clubfoot.

GO Terms for genes affiliated with Clubfoot

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Cellular components related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:00329829.3MYBPC1, MYH3

Biological processes related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hindlimb morphogenesisGO:003513710.3HOXD10, PITX1
2regulation of ATPase activityGO:004346210.1TNNT3, TPM2
3limb morphogenesisGO:003510810.1HOXD13, TBX4
4skeletal muscle contractionGO:00030099.7MYH3, TNNT3
5embryonic limb morphogenesisGO:00303269.4HOXD10, HOXD13, MYH3, TBX4
6muscle filament slidingGO:00300499.0MYBPC1, MYH3, TNNT3, TPM2

Molecular functions related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:00037799.4MYBPC1, TNNT3, TPM2
2structural constituent of muscleGO:00083079.4MYBPC1, TPM2

Sources for Clubfoot

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet