MCID: CLB002
MIFTS: 40

Clubfoot malady

Categories: Genetic diseases (common), Bone diseases

Aliases & Classifications for Clubfoot

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Aliases & Descriptions for Clubfoot:

Name: Clubfoot 11 13 48 37
Congenital Talipes Equinovarus 11
Equinovarus Deformity of Foot 11
 
Congenital Equinovarus 11
Congenital Clubfoot 11
Club Foot 48

Classifications:



Summaries for Clubfoot

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Disease Ontology:11 A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.

MalaCards based summary: Clubfoot, also known as congenital talipes equinovarus, is related to arthrogryposis, distal, type 2b and clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly. An important gene associated with Clubfoot is CHST14 (Carbohydrate Sulfotransferase 14), and among its related pathways are dermatan sulfate biosynthesis and Cardiac conduction. Affiliated tissues include bone, skin and skeletal muscle, and related mouse phenotypes are limbs/digits/tail and skeleton.

Wikipedia:69 Club foot or clubfoot, also called Congenital Talipes Equinovarus (CTEV), is a congenital deformity... more...

Related Diseases for Clubfoot

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Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot

Diseases related to Clubfoot via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1arthrogryposis, distal, type 2b29.2MYBPC1, MYH3, TNNT3, TPM2
2clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly12.2
3short stature robin sequence cleft mandible hand anomalies clubfoot11.9
4pitx1-related congenital clubfoot11.9
5familial clubfoot with or without associated lower limb anomalies11.9
6talipes equinovarus11.5
7ehlers-danlos syndrome, musculocontractural type11.4
8tarp syndrome11.3
9pseudohypoaldosteronism, type iie11.2
10epiphyseal dysplasia, multiple, 411.2
11robin sequence with cleft mandible and limb anomalies11.1
12arthrogryposis, distal, type 311.1
13chromosome 17q23.1-q23.2 duplication syndrome11.0
14ehlers-danlos syndrome, musculocontractural type 110.8
15lambert syndrome10.8
16congenital disorder of glycosylation, type iid10.4MYH3, TPM2
17moebius syndrome10.4
18short qt syndrome 310.3PITX1, TBX4
19abnormal pupillary function10.1ECEL1, TNNT3
20myelomeningocele10.1
21arthrogryposis multiplex congenita, distal, type 110.0
22spondyloepiphyseal dysplasia with congenital joint dislocations10.0
23nemaline myopathy 4, autosomal dominant10.0MYH3, TNNT3, TPM2
24arthrogryposis, distal, type 5d9.9
25diastrophic dysplasia9.9
26atelosteogenesis ii9.9
27smed strudwick type9.9
28loeys-dietz syndrome 59.9
29hydrocephalus-cleft palate-joint contractures syndrome9.9
30ehlers-danlos syndrome9.9
31ramos arroyo clark syndrome9.8CHST14, TNNT3
32vertical talus, congenital9.8
33spondylocarpotarsal synostosis syndrome9.8
34larsen syndrome9.8
35bruck syndrome 29.8
36orofaciodigital syndrome iv9.8
37spondyloperipheral dysplasia9.8
38arthrogryposis, distal, type 1b9.8
39epileptic encephalopathy, early infantile, 299.8
40tibial hemimelia9.8
41potocki-lupski syndrome9.8
42marden-walker syndrome9.8
43central core disease9.8
44diastematomyelia9.8
45hemangioma9.8
46osteoarthritis9.8
47distal arthrogryposis9.8
48congenital fiber-type disproportion9.8
49esophageal atresia9.8
50imperforate anus9.8

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Symptoms for Clubfoot

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Drugs & Therapeutics for Clubfoot

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Drugs for Clubfoot (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholinePhase 4, Phase 3, Phase 275251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2
Menthol21842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

(show all 37)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic PatientsCompletedNCT00825097Phase 3
3Study of GSK1358820 In Patients With Post-Stroke Lower Limb SpasticityCompletedNCT00460655Phase 3
4Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral PalsyRecruitingNCT02188277Phase 2
5Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRICompletedNCT01088828
6Gait Analysis in Ponseti ClubfootCompletedNCT02022267
7Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)CompletedNCT00474344
8Polyaxial Brace Fixing for the Treatment of Congenital ClubfootCompletedNCT02815306
9Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti MethodCompletedNCT01067651
10Outcomes of Compliance With Brace Wear in ClubfootCompletedNCT01481324
11A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot InfantsCompletedNCT02395185
12Treatment of Spastic Equinovarus Foot After StrokeCompletedNCT00199589
13Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootCompletedNCT01265238
14Impairments of Oral Language in Mobius SyndromeCompletedNCT00856531
15Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and ClubfeetRecruitingNCT02755766
16Clubfoot DNA RepositoryRecruitingNCT00607191
17Using Botox to Treat Patients With Idiopathic ClubfootRecruitingNCT00474032
18Pedobarographic Assessments of Clubfoot Treated PatientsRecruitingNCT00175708
19Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic ClubfootRecruitingNCT02815215Phase 0
20Prospective Evaluation of Treatment for ClubfootRecruitingNCT02257229
21Effectiveness of Parents' Manipulation in Newborn With Talipes CalcaneusRecruitingNCT01767662
22Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar PressureRecruitingNCT02233140
23Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
24Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus FootRecruitingNCT02790346
25Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized TrialActive, not recruitingNCT01551264
26Efficacy of Botox in Patients With Idiopathic ClubfootActive, not recruitingNCT00152334
27A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic ClubfootActive, not recruitingNCT00152347
28Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
29Genetic Disease Gene IdentificationEnrolling by invitationNCT00916903
30Sucrose Analgesia in Infants Undergoing Casting for Club FootNot yet recruitingNCT01050088
31Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral PalsyNot yet recruitingNCT02814786
32Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA)Not yet recruitingNCT01600183
33Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles TendonSuspendedNCT01382628
34Ankle Equinus Contracture Treated With Dynamic SplintingTerminatedNCT01238484
35The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon FracturesTerminatedNCT02051933
36Economic Evaluation of Clubfoot Treatment: One Centre's ExperienceWithdrawnNCT00475631
37Instep Plantar Fasciotomy With and Without Gastrocnemius RecessionWithdrawnNCT02287714

Search NIH Clinical Center for Clubfoot


Cochrane evidence based reviews: clubfoot

Genetic Tests for Clubfoot

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Anatomical Context for Clubfoot

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MalaCards organs/tissues related to Clubfoot:

34
Bone, Skin, Skeletal muscle

Animal Models for Clubfoot or affiliated genes

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MGI Mouse Phenotypes related to Clubfoot:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.4CHST14, HOXD10, HOXD13, PITX1, TBX4, TNNT3
2MP:00053906.7CHST14, CHST3, ECEL1, HOXD10, HOXD13, PITX1

Publications for Clubfoot

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Articles related to Clubfoot:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus. (26729820)
2016
2
Results of clubfoot treatment after manipulation and casting using the Ponseti method: experience in Harare, Zimbabwe. (27388947)
2016
3
Ponseti method compared to previous treatment of clubfoot in Norway. A multicenter study of 205 children followed for 8-11A years. (27436118)
2016
4
Initial Correction Predicts the Need for Secondary Achilles Tendon Procedures in Patients With Idiopathic Clubfoot Treated With Ponseti Casting. (25730291)
2015
5
What is the fate of clubfoot patients treated by posteromedial release? (25854655)
2015
6
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
7
Worldwide spread of the Ponseti method for clubfoot. (25405086)
2014
8
Classification of relapse pattern in clubfoot treated with Ponseti technique. (25298569)
2014
9
Idiopathic clubfoot: ten year follow-up after a soft tissue release procedure. (25231572)
2014
10
Ponseti clubfoot management: Experience with the Steenbeek foot abduction brace. (25587223)
2014
11
Calf Circumference Discrepancies in Patients With Unilateral Clubfoot: Ponseti Versus Surgical Release. (25122080)
2014
12
Propofol sedation for infants with idiopathic clubfoot undergoing percutaneous tendoachilles tenotomy. (23232381)
2013
13
Evaluation of online health information on clubfoot using the DISCERN tool. (24048196)
2013
14
Update on clubfoot. (23586398)
2013
15
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
2012
16
Relapse after tibialis anterior tendon transfer in idiopathic clubfoot treated by the Ponseti method. (22173393)
2012
17
An MRI volumetric study for leg muscles in congenital clubfoot. (24082959)
2012
18
Post clubfoot release skin necrosis: a preventable disaster. (21526037)
2011
19
Long-term results of the posteromedial release in the treatment of idiopathic clubfoot. (20864856)
2010
20
Clubfoot classification: correlation with Ponseti cast treatment. (20864855)
2010
21
Bracing following correction of idiopathic clubfoot using the Ponseti method. (20675641)
2010
22
Long-term outcome evaluation in young adults following clubfoot surgical release. (20502239)
2010
23
Has the rate of extensive surgery to treat idiopathic clubfoot declined in the United States? (20360511)
2010
24
Loss of dermatan-4-sulfotransferase 1 function results in adducted thumb-clubfoot syndrome. (20004762)
2009
25
Ponseti treatment for idiopathic clubfoot: minimum 5-year followup. (19130158)
2009
26
The association between idiopathic clubfoot and increased internal hip rotation. (19229661)
2009
27
Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot. (19142688)
2009
28
Mini-open technique for the achilles tenotomy in correction of idiopathic clubfoot: a report of 25 cases. (18820046)
2008
29
HOXD13 may play a role in idiopathic congenital clubfoot by regulating the expression of FHL1. (18758158)
2008
30
Use of the Ponseti method for recurrent clubfoot following posteromedial release. (19823658)
2008
31
Neuromuscular disease as the cause of late clubfoot relapses: report of 4 cases. (17907435)
2007
32
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)
2007
33
"Different" approach in the operative treatment of congenital clubfoot and its results. (16796130)
2006
34
Congenital idiopathic clubfoot: prevention of late deformity and disability by conservative treatment with the Ponseti technique. (16493919)
2006
35
Incidence of congenital clubfoot in Sweden. (17260191)
2006
36
Three-dimensional hindfoot motion in adolescents with surgically treated unilateral clubfoot. (16199945)
2005
37
Validity of the anteroposterior talocalcaneal angle to assess congenital clubfoot correction. (15100132)
2004
38
Functional treatment of clubfoot: a new series of 350 idiopathic clubfeet with long-term follow-up. (15083120)
2004
39
Role of Joshi's external stabilisation system fixator in the management of idiopathic clubfoot. (14676347)
2003
40
Percutaneous fixation in clubfoot surgery: a radiographic and gait study. (11943988)
2002
41
Regional fasciocutaneous flap closure for clubfoot surgery. (11176353)
2001
42
Peritalar release in the treatment of congenital talipes equinovarus clubfoot. (12056243)
2001
43
Comparison of the soft-tissue release methods in idiopathic clubfoot. (11008747)
2000
44
Evaluation of the walking pattern in clubfoot patients who received early intensive treatment. (11008746)
2000
45
Surgical treatment of clubfoot: the significance of talocalcaneonavicular malposition correction. (10709589)
1999
46
Cases of congenital dislocation of the knee (CDK) not associated with clubfoot, arthrogryposis multiplex congenita, and Larsen's syndrome can be treated conservatively. (9531418)
1998
47
Muscle and tendon size relationships in a paralyzed chick embryo model of clubfoot. (9600555)
1998
48
Treatment of idiopathic clubfoot. A thirty-year follow-up note. (8876592)
1996
49
Esophageal atresia, coloboma, and clubfoot in two unrelated infants. (6469248)
1984
50
HLA and clubfoot (idiopathic talipes equinovarus). (7071822)
1982

Variations for Clubfoot

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Expression for genes affiliated with Clubfoot

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Search GEO for disease gene expression data for Clubfoot.

GO Terms for genes affiliated with Clubfoot

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Cellular components related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:00329829.5MYBPC1, MYH3

Biological processes related to Clubfoot according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of ATPase activityGO:004346210.2TNNT3, TPM2
2hindlimb morphogenesisGO:003513710.2HOXD10, PITX1
3skeletal muscle contractionGO:000300910.1MYH3, TNNT3
4limb morphogenesisGO:00351089.9HOXD13, TBX4
5embryonic hindlimb morphogenesisGO:00351169.5PITX1, WNT7A
6embryonic digit morphogenesisGO:00427339.4HOXD13, WNT7A
7muscle filament slidingGO:00300498.8MYBPC1, MYH3, TNNT3, TPM2
8embryonic limb morphogenesisGO:00303268.2HOXD10, HOXD13, MYH3, TBX4, WNT7A

Molecular functions related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:00083079.5MYBPC1, TPM2
2actin bindingGO:00037799.2MYBPC1, TNNT3, TPM2

Sources for Clubfoot

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet