MCID: CLB002
MIFTS: 47

Clubfoot malady

Categories: Genetic diseases, Bone diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Clubfoot

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Aliases & Descriptions for Clubfoot:

Name: Clubfoot 10 47 12 36
Congenital Talipes Equinovarus 10
Equinovarus Deformity of Foot 10
 
Congenital Equinovarus 10
Congenital Clubfoot 10
Club Foot 47

Classifications:



External Ids:

Disease Ontology10 DOID:11836
ICD1027 Q66.0, Q66.89
ICD9CM29 754.51
MeSH36 D003025
NCIt42 C84641
UMLS65 C0009081

Summaries for Clubfoot

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Disease Ontology:10 A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.

MalaCards based summary: Clubfoot, also known as congenital talipes equinovarus, is related to arthrogryposis, distal, type 2b and clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly. An important gene associated with Clubfoot is CHST14 (Carbohydrate (Dermatan 4) Sulfotransferase 14), and among its related pathways are dermatan sulfate biosynthesis and Cardiac conduction. Affiliated tissues include bone, breast and brain, and related mouse phenotypes are muscle and limbs/digits/tail.

Wikipedia:68 Club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

Related Diseases for Clubfoot

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Diseases in the Clubfoot family:

Pitx1-Related Congenital Clubfoot Familial Clubfoot Due to Pitx1 Point Mutation

Diseases related to Clubfoot via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1arthrogryposis, distal, type 2b29.2MYBPC1, MYH3, TNNT3, TPM2
2clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly12.1
3familial clubfoot due to 17q23.1q23.2 microduplication11.9
4familial clubfoot due to pitx1 point mutation11.9
5familial clubfoot due to 5q31 microdeletion11.9
6short stature robin sequence cleft mandible hand anomalies clubfoot11.8
7pitx1-related congenital clubfoot11.8
8familial clubfoot with or without associated lower limb anomalies11.8
9talipes equinovarus11.5
10ehlers-danlos syndrome, musculocontractural type11.4
11tarp syndrome11.3
12pseudohypoaldosteronism, type iie11.2
13epiphyseal dysplasia, multiple, 411.2
14robin sequence with cleft mandible and limb anomalies11.1
15arthrogryposis, distal, type 311.1
16ehlers-danlos syndrome, musculocontractural type 110.8
17lambert syndrome10.8
18chromosome 17q23.1-q23.2 duplication syndrome10.5PITX1, TBX4
19moebius syndrome10.4
20congenital disorder of glycosylation, type iid10.4MYH3, TPM2
21hypertensive heart disease10.2ECEL1, TNNT3
22congenital craniosynostosis maternal hyperthyroiditis10.2CHST14, TNNT3
23arthrogryposis multiplex congenita, distal, type 110.0
24spondyloepiphyseal dysplasia with congenital joint dislocations10.0
25myelomeningocele10.0
26nut midline carcinoma9.9CHST3, SLC26A2
27arthrogryposis, distal, type 5d9.9
28diastrophic dysplasia9.9
29atelosteogenesis ii9.9
30smed strudwick type9.9
31loeys-dietz syndrome 59.9
32nemaline myopathy 4, autosomal dominant9.9MYH3, TNNT3, TPM2
33ehlers-danlos syndrome9.9
34syndactyly, type v9.9HOXD10, HOXD13
35brachydactyly-syndactyly syndrome9.8HOXD10, HOXD13
36cylindrical spirals myopathy9.8TNNT3, TPM2
37vertical talus, congenital9.8
38spondylocarpotarsal synostosis syndrome9.8
39larsen syndrome9.8
40bruck syndrome 29.8
41orofaciodigital syndrome iv9.8
42spondyloperipheral dysplasia9.8
43arthrogryposis, distal, type 1b9.8
44epileptic encephalopathy, early infantile, 299.8
45tibial hemimelia9.8
46potocki-lupski syndrome9.8
47marden-walker syndrome9.8
48central core disease9.8
49hemangioma9.8
50osteoarthritis9.8

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to clubfoot

Symptoms for Clubfoot

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Drugs & Therapeutics for Clubfoot

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Drugs for Clubfoot (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AbobotulinumtoxinAPhase 4, Phase 3, Phase 2588
2IncobotulinumtoxinAPhase 4, Phase 3, Phase 2599
3OnabotulinumtoxinAPhase 4, Phase 3, Phase 2588
4Botulinum Toxins, Type APhase 4, Phase 3, Phase 2588
5
AcetylcholineexperimentalPhase 3, Phase 268951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
6Neurotransmitter AgentsPhase 3, Phase 214795
7Peripheral Nervous System AgentsPhase 3, Phase 218510
8Neuromuscular AgentsPhase 3, Phase 2922
9Cholinergic AgentsPhase 3, Phase 23243
10Botulinum ToxinsPhase 3, Phase 2616
11AnestheticsPhase 37385
12Pharmaceutical SolutionsPhase 27004
13HemagglutininsPhase 2111
14Analgesics9358
15AstragalusNutraceutical48

Interventional clinical trials:

(show all 33)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic PatientsCompletedNCT00825097Phase 3
3Study of GSK1358820 In Patients With Post-Stroke Lower Limb SpasticityCompletedNCT00460655Phase 3
4Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral PalsyRecruitingNCT02188277Phase 2
5Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRICompletedNCT01088828
6Gait Analysis in Ponseti ClubfootCompletedNCT02022267
7Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)CompletedNCT00474344
8Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti MethodCompletedNCT01067651
9Outcomes of Compliance With Brace Wear in ClubfootCompletedNCT01481324
10A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot InfantsCompletedNCT02395185
11Treatment of Spastic Equinovarus Foot After StrokeCompletedNCT00199589
12Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootCompletedNCT01265238
13Impairments of Oral Language in Mobius SyndromeCompletedNCT00856531
14Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and ClubfeetRecruitingNCT02755766
15Clubfoot DNA RepositoryRecruitingNCT00607191
16Using Botox to Treat Patients With Idiopathic ClubfootRecruitingNCT00474032
17Pedobarographic Assessments of Clubfoot Treated PatientsRecruitingNCT00175708
18Prospective Evaluation of Treatment for ClubfootRecruitingNCT02257229
19Effectiveness of Parents' Manipulation in Newborn With Talipes CalcaneusRecruitingNCT01767662
20Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar PressureRecruitingNCT02233140
21Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
22Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized TrialActive, not recruitingNCT01551264
23Efficacy of Botox in Patients With Idiopathic ClubfootActive, not recruitingNCT00152334
24A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic ClubfootActive, not recruitingNCT00152347
25Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
26Genetic Disease Gene IdentificationEnrolling by invitationNCT00916903
27Sucrose Analgesia in Infants Undergoing Casting for Club FootNot yet recruitingNCT01050088
28Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA)Not yet recruitingNCT01600183
29Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles TendonSuspendedNCT01382628
30Ankle Equinus Contracture Treated With Dynamic SplintingTerminatedNCT01238484
31The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon FracturesTerminatedNCT02051933
32Economic Evaluation of Clubfoot Treatment: One Centre's ExperienceWithdrawnNCT00475631
33Instep Plantar Fasciotomy With and Without Gastrocnemius RecessionWithdrawnNCT02287714

Search NIH Clinical Center for Clubfoot


Cochrane evidence based reviews: clubfoot

Genetic Tests for Clubfoot

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Anatomical Context for Clubfoot

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MalaCards organs/tissues related to Clubfoot:

33
Bone, Breast, Brain, Prostate, Kidney, Liver, Heart

Animal Models for Clubfoot or affiliated genes

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MGI Mouse Phenotypes related to Clubfoot:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5ECEL1, HOXD10, HOXD13, PITX1, TNNT3
2MP:00053718.4CHST14, HOXD10, HOXD13, PITX1, SLC26A2, TBX4
3MP:00053907.1CHST14, CHST3, ECEL1, HOXD10, HOXD13, PITX1

Publications for Clubfoot

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Articles related to Clubfoot:

(show top 50)    (show all 588)
idTitleAuthorsYear
1
Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus. (26729820)
2016
2
Conservative treatment of severe clubfoot using a novel functional dynamic splint. (25438104)
2015
3
Initial Correction Predicts the Need for Secondary Achilles Tendon Procedures in Patients With Idiopathic Clubfoot Treated With Ponseti Casting. (25730291)
2015
4
The effect of clinical, radiographic and functional scores on the total score in the evaluation of congenital clubfoot. (25568547)
2014
5
Ponseti treatment for clubfoot in Romania: a 9-year single-centre experience. (25153646)
2014
6
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
7
Comment on Morin et al "Positive Communication Paradigm Decreases Early Recurrence in Clubfoot Treatment" (25122079)
2014
8
Is tibialis anterior tendon transfer effective for recurrent clubfoot? (24061847)
2014
9
Worldwide spread of the Ponseti method for clubfoot. (25405086)
2014
10
Propofol sedation for infants with idiopathic clubfoot undergoing percutaneous tendoachilles tenotomy. (23232381)
2013
11
Descriptive epidemiology of idiopathic clubfoot. (23686911)
2013
12
Low prevalence of osteoarthritis in patients with congenital clubfoot at more than 60 years' follow-up. (23109633)
2012
13
Treatment results of late-relapsing idiopathic clubfoot previously treated with the Ponseti method. (22584843)
2012
14
Post clubfoot release skin necrosis: a preventable disaster. (21526037)
2011
15
The influence of brace type on the success rate of the Ponseti treatment protocol for idiopathic clubfoot. (22468155)
2011
16
Long-term results of the posteromedial release in the treatment of idiopathic clubfoot. (20864856)
2010
17
Clubfoot classification: correlation with Ponseti cast treatment. (20864855)
2010
18
Magnetic resonance angiography in clubfoot and vertical talus: a feasibility study. (19127394)
2009
19
CT study on the effect of different treatment protocols for clubfoot pathology. (19190974)
2009
20
Early results of the Ponseti method for the treatment of clubfoot associated with myelomeningocele. (19487512)
2009
21
Clubfoot: etiology and treatment Ignacio V. Ponseti, MD, 1914-. (19184257)
2009
22
Clubfoot treatment: Ponseti and French functional methods are equally effective. (19242767)
2009
23
Evaluation of the utility of the Ponseti method of correction of clubfoot deformity in a developing nation. (17115153)
2008
24
Results of manipulation of idiopathic clubfoot deformity in Malawi by orthopaedic clinical officers using the Ponseti method: a realistic alternative for the developing world? (18209628)
2007
25
Results of an accelerated Ponseti protocol for clubfoot. (16199943)
2005
26
Radical soft-tissue release of the arthrogrypotic clubfoot. (15703521)
2005
27
Bleeding complications following percutaneous tendoachilles tenotomy in the treatment of clubfoot deformity. (15205614)
2004
28
Validity of the anteroposterior talocalcaneal angle to assess congenital clubfoot correction. (15100132)
2004
29
The effect of the internet in the treatment of congenital idiopathic clubfoot. (14575256)
2003
30
Anthropometric study of patients treated for clubfoot. (12826950)
2003
31
Joint laxity and the risk of clubfoot. (14632308)
2003
32
The ponseti technique for correction of congenital clubfoot. (12377924)
2002
33
Regional fasciocutaneous flap closure for clubfoot surgery. (11176353)
2001
34
Anterior tibial tendon transfer in residual dynamic clubfoot deformity. (11176351)
2001
35
Ankle and first metatarsophalangeal joint dorsiflexion in children with clubfoot. (11675544)
2001
36
Comparison of the soft-tissue release methods in idiopathic clubfoot. (11008747)
2000
37
Postoperative blood loss into plaster casts after clubfoot surgery: an experimental model. (10218182)
1999
38
Surgical treatment of clubfoot: the significance of talocalcaneonavicular malposition correction. (10709589)
1999
39
Rotation fasciocutaneous flap for neglected clubfoot: a new technique. (9600556)
1998
40
Cases of congenital dislocation of the knee (CDK) not associated with clubfoot, arthrogryposis multiplex congenita, and Larsen's syndrome can be treated conservatively. (9531418)
1998
41
Long-term results of the operative treatment of clubfoot: a representative study. (9642705)
1998
42
Regional anesthesia for clubfoot surgery in children. (10099069)
1998
43
Muscle and tendon size relationships in a paralyzed chick embryo model of clubfoot. (9600555)
1998
44
A personal revolution in the development of clubfoot correction. (9030444)
1997
45
Controversies in the surgical management of clubfoot. (8727753)
1996
46
Esophageal atresia, coloboma, and clubfoot in two unrelated infants. (6469248)
1984
47
48
49
50

Variations for Clubfoot

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Expression for genes affiliated with Clubfoot

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Search GEO for disease gene expression data for Clubfoot.

GO Terms for genes affiliated with Clubfoot

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Biological processes related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1skeletal muscle contractionGO:00030099.8MYH3, TNNT3
2embryonic limb morphogenesisGO:00303269.7HOXD10, TBX4

Molecular functions related to Clubfoot according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.3PITX1, ZNF664
2actin bindingGO:00037799.2MYBPC1, TNNT3, TPM2

Sources for Clubfoot

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet